Search results for: Sibulelo L. Vilakazi

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Vilakazi</title> <meta name="description" content="Search results for: Sibulelo L. Vilakazi"> <meta name="keywords" content="Sibulelo L. Vilakazi"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Sibulelo L. 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Vilakazi"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Sibulelo L. Vilakazi</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> A Nanosensor System Based on Disuccinimydyl – CYP2E1 for Amperometric Detection of the Anti-Tuberculosis Drug, Pyrazinamide </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rachel%20F.%20Ajayi">Rachel F. Ajayi</a>, <a href="https://publications.waset.org/abstracts/search?q=Unathi%20Sidwaba"> Unathi Sidwaba</a>, <a href="https://publications.waset.org/abstracts/search?q=Usisipho%20Feleni"> Usisipho Feleni</a>, <a href="https://publications.waset.org/abstracts/search?q=Samantha%20F.%20Douman"> Samantha F. Douman</a>, <a href="https://publications.waset.org/abstracts/search?q=Ezo%20Nxusani"> Ezo Nxusani</a>, <a href="https://publications.waset.org/abstracts/search?q=Lindsay%20Wilson"> Lindsay Wilson</a>, <a href="https://publications.waset.org/abstracts/search?q=Candice%20Rassie"> Candice Rassie</a>, <a href="https://publications.waset.org/abstracts/search?q=Oluwakemi%20Tovide"> Oluwakemi Tovide</a>, <a href="https://publications.waset.org/abstracts/search?q=Priscilla%20G.L.%20Baker"> Priscilla G.L. Baker</a>, <a href="https://publications.waset.org/abstracts/search?q=Sibulelo%20L.%20Vilakazi"> Sibulelo L. Vilakazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20Tshikhudo"> Robert Tshikhudo</a>, <a href="https://publications.waset.org/abstracts/search?q=Emmanuel%20I.%20Iwuoha"> Emmanuel I. Iwuoha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Pyrazinamide (PZA) is among the first-line pro-drugs in the tuberculosis (TB) combination chemotherapy used to treat Mycobacterium tuberculosis. Numerous reports have suggested that hepatotoxicity due to pyrazinamide in patients is due to inappropriate dosing. It is therefore necessary to develop sensitive and reliable techniques for determining the PZA metabolic profile of diagnosed patients promptly and at point-of-care. This study reports the determination of PZA based on nanobiosensor systems developed from disuccinimidyl octanedioate modified Cytochrome P450-2E1 (CYP2E1) electrodeposited on gold substrates derivatised with (poly(8-anilino-1-napthalene sulphonic acid) PANSA/PVP-AgNPs nanocomposites. The rapid and sensitive amperometric PZA detection gave a dynamic linear range of 2 µM to 16 µM revealing a limit of detection of 0.044 µM and a sensitivity of 1.38 µA/µM. The Michaelis-Menten parameters; KM, KMapp and IMAX were also calculated and found to be 6.0 µM, 1.41 µM and 1.51 µA respectively indicating a nanobiosensor suitable for use in serum. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tuberculosis" title="tuberculosis">tuberculosis</a>, <a href="https://publications.waset.org/abstracts/search?q=cytochrome%20P450-2E1" title=" cytochrome P450-2E1"> cytochrome P450-2E1</a>, <a href="https://publications.waset.org/abstracts/search?q=disuccinimidyl%20octanedioate" title=" disuccinimidyl octanedioate"> disuccinimidyl octanedioate</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrazinamide" title=" pyrazinamide"> pyrazinamide</a> </p> <a href="https://publications.waset.org/abstracts/2694/a-nanosensor-system-based-on-disuccinimydyl-cyp2e1-for-amperometric-detection-of-the-anti-tuberculosis-drug-pyrazinamide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2694.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">414</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> A Synopsis of Green Energy Technology Implementation In South Africa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sifiso%20Vilakazi">Sifiso Vilakazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Lerato%20Mzenzi"> Lerato Mzenzi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> BACKGROUND :- Human mind is a double-edged sword, it is both arduous and obtuse, vague and explicit. The neuroscience of brain has baffled all and left none. In this labyrinth, a novel neurotransmitter has set its foot. D-Aspartic acid, which has been established in rats and animals’ brain as a neurochemical in controlling behaviour, aggression, fertility, cognition and memory is set to formulate a new benchmark as a marker among suicidal and accidental death victims. Without losing sight of the fact, we have endeavoured to dig out the biochemical relation behind suicide in our research. We in our research have exerted to decipher the puzzle among humans for D-Aspartic acid using HPLC. METHODS:- We have taken 30 samples each of pre-frontal cortex of brain from suicide and road traffic accidents victims for our case-control research to establish brain D-Aspartic acid level using HPLC as a marker for suicide. RESULTS:- By using Independent/Unpaired T-Test Analysis:- The two-tailed P value is less than 0.0044. MEAN (mMOL/mL/G) for D-Aspartic acid in control is 24.2737±7.5958 and for cases is 19.5540±4.2647. By conventional criteria, this difference is considered to be extremely statistically significant. CONCLUSION:- (1) Brain D-Aspartic acid has an effect in the act of suicide and its values show a large drop before the act of suicide is commenced as compared to road traffic accidents which correlates with the study where D-AA was studied as a novel endogenous neurotransmitter in case of mental health disorders in humans, though never studied on suicide victims, likely getting it reference from research occurring on rats where it was discovered that D-AA plays a role in cognition, personality development, thought process, aggression. (2)The other study which was related to humans and signified the role of D-AA in reproduction, where low D-AA leads to infertility and depression and hence providing the much needed proof of role of D-AA in mental health disorders and suicide, and subsequently to the act of suicide. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=green%20energy" title="green energy">green energy</a>, <a href="https://publications.waset.org/abstracts/search?q=policy" title=" policy"> policy</a>, <a href="https://publications.waset.org/abstracts/search?q=technology" title=" technology"> technology</a>, <a href="https://publications.waset.org/abstracts/search?q=implementation" title=" implementation"> implementation</a> </p> <a href="https://publications.waset.org/abstracts/195382/a-synopsis-of-green-energy-technology-implementation-in-south-africa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/195382.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">7</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> The Role of Technology in Managing Election Logistics and Preventing Fraud in Nigeria and Uganda: A Comparative Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sifiso%20Vilakazi">Sifiso Vilakazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Lerato%20Mzenzi"> Lerato Mzenzi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The incorporation of technology has brought about a considerable evolution in election management, providing answers to persistent issues with fraud, inefficiency, and logistical complexity. The paper offers a comparative review of the effects of technology advancements on election logistics and fraud prevention in Uganda and Nigeria. Both nations have embraced technology such as digital fraud prevention systems, biometric voter registration, and electronic results transmission while having different political environments and electoral problems. Nevertheless, these innovations' varied results raise important concerns about how technology can enhance vote integrity. For improved transparency and lower voter fraud, the Independent National Electoral Commission (INEC) of Nigeria has deployed electronic voting machines, biometric voter identification, and the INEC Result Viewing (IReV) portal. Despite these developments, technological setbacks and logistical difficulties, particularly during the 2023 elections, uncovered weaknesses that stoked distrust and electoral conflicts by exposing flaws, including device breakdowns, insufficient cybersecurity protections, and transmission delays in results. Comparably, Uganda has used electronic result transmission technologies and biometric voter verification since 2016 to increase election efficiency and combat ballot stuffing and impersonation. Nevertheless, problems, including remote logistical challenges and internet outages during the 2021 elections, have reduced the efficacy of these tools. This paper maintains that while technology might reduce election-related stress and potentially reduce fraud, its efficacy depends on several variables, such as political will, public confidence, and infrastructure. Furthermore, it draws attention to the necessity of more robust legislative frameworks, ongoing investments in cybersecurity, and implementation plans that are customized to the particular difficulties presented by each nation's voting system locally. The results imply that although technology can help Ugandan and Nigerian election management, it cannot guarantee electoral integrity and must be used in conjunction with more extensive institutional changes. Through providing insights into how African nations might use technological advancements to improve democratic governance while addressing context-specific problems, the research adds to the expanding body of literature on the use of technology in election management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=elections" title="elections">elections</a>, <a href="https://publications.waset.org/abstracts/search?q=Nigeria" title=" Nigeria"> Nigeria</a>, <a href="https://publications.waset.org/abstracts/search?q=Uganda" title=" Uganda"> Uganda</a>, <a href="https://publications.waset.org/abstracts/search?q=Africa" title=" Africa"> Africa</a>, <a href="https://publications.waset.org/abstracts/search?q=management" title=" management"> management</a>, <a href="https://publications.waset.org/abstracts/search?q=innovation" title=" innovation"> innovation</a> </p> <a href="https://publications.waset.org/abstracts/195709/the-role-of-technology-in-managing-election-logistics-and-preventing-fraud-in-nigeria-and-uganda-a-comparative-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/195709.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">4</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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Search results for: Sibulelo L. Vilakazi