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elementor-element-515b706 e-flex e-con-boxed e-con e-parent" data-id="515b706" data-element_type="container"> <div data-rocket-location-hash="547ec2470d2bda10abb0f19dcabad963" class="e-con-inner"> </div> </div> <section class="elementor-section elementor-top-section elementor-element elementor-element-41d0450 elementor-section-full_width container pb-5 mb-md-2 mb-lg-4 elementor-section-height-default elementor-section-height-default" data-id="41d0450" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8308220" data-id="8308220" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-fc58fe7 elementor-widget elementor-widget-highlighted-heading" data-id="fc58fe7" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h1 class="silicon-elementor-highlighted-heading__title border-bottom pb-4"><span class="silicon-elementor-highlighted-heading__highlighted-text text-gradient-primary">Antibody humanization</span></h1> </div> </div> <div class="elementor-section elementor-inner-section elementor-element elementor-element-ad7641a elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="ad7641a" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row pt-2 pt-md-3 row-margin"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6f335c7 col-md-6" data-id="6f335c7" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-fc2a867 elementor-widget elementor-widget-highlighted-heading" data-id="fc2a867" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg pe-lg-4 mb-1 mb-lg-4"><span class="si-multipurpose-text__before">Transform your antibody candidates into effective therapeutics with our deep learning aided humanization services. Whether you need expert support or a powerful self-service software solution, we provide the flexibility and precision you need to streamline your projects.</span></p> </div> </div> <div class="elementor-element elementor-element-6629b70 elementor-widget elementor-widget-spacer" data-id="6629b70" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <div class="elementor-element elementor-element-77f1bae elementor-widget elementor-widget-button" data-id="77f1bae" data-element_type="widget" data-widget_type="button.button-silicon"> <div class="elementor-widget-container"> <a class="shadow-primary silicon-button btn btn-primary btn-lg" href="https://enpicom.com/services-form/" role="button"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text silicon-button-text order-last">Talk to our experts</span> </span> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-8bf9de3 col-md-6" data-id="8bf9de3" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-12624ec elementor-widget elementor-widget-image" data-id="12624ec" data-element_type="widget" data-widget_type="image.si-image-jp"> <div class="elementor-widget-container"> <img fetchpriority="high" decoding="async" data-jarallax-element="" data-disable-parallax-down="" width="2048" height="1068" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%202048%201068'%3E%3C/svg%3E" class="rounded-3 shadow-sm attachment-full size-full wp-image-7498" alt="Antibody humanization services by ENPICOM" data-lazy-srcset="https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224.png 2048w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-300x156.png 300w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-1024x534.png 1024w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-768x401.png 768w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-1536x801.png 1536w" data-lazy-sizes="(max-width: 2048px) 100vw, 2048px" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224.png" /><noscript><img fetchpriority="high" decoding="async" data-jarallax-element="" data-disable-parallax-down="" width="2048" height="1068" src="https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224.png" class="rounded-3 shadow-sm attachment-full size-full wp-image-7498" alt="Antibody humanization services by ENPICOM" srcset="https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224.png 2048w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-300x156.png 300w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-1024x534.png 1024w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-768x401.png 768w, https://enpicom.com/wp-content/uploads/2024/08/ML-antibody-humanization-e1723204240224-1536x801.png 1536w" sizes="(max-width: 2048px) 100vw, 2048px" /></noscript> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-394f27d mb-5 pt-md-2 pt-lg-4 pt-xl-5 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="394f27d" data-element_type="section"> <div class="elementor-container elementor-column-gap-default container mt-4 pt-2 flex-wrap"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d5b07c7 col-12" data-id="d5b07c7" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4a0359f elementor-widget elementor-widget-highlighted-heading" data-id="4a0359f" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title border-bottom pb-4"><span class="si-multipurpose-text__before">Comparing humanization approaches</span></h2> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-61acaf1 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="61acaf1" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row row-cols-md-2 row-cols-1 gy-4 mb-5 row-margin"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-cd3070f col" data-id="cd3070f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7bb2e76 elementor-widget elementor-widget-highlighted-heading" data-id="7bb2e76" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title mb-0 fs-lg"><span class="si-multipurpose-text__before">Antibody humanization is a crucial step in reducing immunogenicity while maintaining therapeutic efficacy, essential for advancing a drug to the clinic. Traditional grafting methods, where CDRs are transferred from the parental molecule to human frameworks, are laborious, time-consuming, typically low throughput, and often reduce binding affinity. Deep learning has proven capable of overcoming some of these challenges, but current models like BioPhi still tend to fall short in retaining binding affinity for most generated variants. </span></p> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-92feb06 col" data-id="92feb06" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7599111 elementor-widget elementor-widget-highlighted-heading" data-id="7599111" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title mb-0 fs-lg"><span class="si-multipurpose-text__before">ENPICOM’s generative deep-learning humanization model eliminates the need for traditional grafting while showing far superior performance in retaining binding affinity when compared to models like BioPhi. Achieving higher success rates with fewer screened variants increases efficiency in both time and cost. Typically, screening just 3-5 humanized variants per parental clone is already enough to find a candidate that retains binding affinity.</span></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-4da5a6d elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="4da5a6d" data-element_type="section"> <div class="elementor-container elementor-column-gap-default container my-5 py-lg-5 py-md-4 pt-2 pb-3"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f564bdf" data-id="f564bdf" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-3b66875 elementor-widget elementor-widget-highlighted-heading" data-id="3b66875" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title mb-md-4 border-bottom pb-4"><span class="si-multipurpose-text__before">The ENPICOM humanization model</span></h2> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-ed1e0ca elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="ed1e0ca" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row gy-4 mb-5 pb-xl-5 pb-md-4 pb-3 row-margin"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7dcd84c col-lg-5 col-md-6 order-md-1 order-2 d-flex rellax" data-id="7dcd84c" data-element_type="column" data-rellax-percentage="0.5" data-rellax-speed="-0.5" data-disable-parallax-down="md" style="transform: translate3d(8px, -4px, 0px);"> <div class="align-self-center pe-lg-0 pe-md-4 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-d011ff2 elementor-widget elementor-widget-highlighted-heading" data-id="d011ff2" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title mb-md-4 mb-3 fs-lg"><span class="si-multipurpose-text__before">The significantly improved binding retention at clinically relevant humanness levels leads to considerable time and cost savings. With better retention, fewer sequences need to be screened, and sequence generation is faster. How is this achieved? <br> <br>The ENPICOM humanization model is built on our proprietary paired chain protein language model (pLM), which is part of our AIGX pLM family. In addition, we have trained a generative interface to suggest mutations that optimize sequence humanness, while allowing flexibility to protect residues expected to be key for binding. Besides, the model is designed to function agnostically with regard to the parental species and is fully flexible to account for optional additional restrictions. As a result, it can be run as a self-service software solution or operated by one of our experts as a service.</span></p> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-78f5895 col-md-6 offset-lg-1 order-md-2 order-1 rellax" data-id="78f5895" data-element_type="column" data-rellax-percentage="0.5" data-rellax-speed="0.5" data-disable-parallax-down="md" style="transform: translate3d(6px, 2px, 0px);"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-299092a bg-secondary rounded-3 d-dark-mode-none d-block elementor-widget elementor-widget-image" data-id="299092a" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="1111" height="943" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201111%20943'%3E%3C/svg%3E" class="rounded-3 attachment-full size-full wp-image-12117" alt="Intuitive user interface of the ENPICOM Platform" data-lazy-srcset="https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP.png 1111w, https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP-300x255.png 300w, https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP-1024x869.png 1024w, https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP-768x652.png 768w" data-lazy-sizes="(max-width: 1111px) 100vw, 1111px" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP.png" /><noscript><img decoding="async" width="1111" height="943" src="https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP.png" class="rounded-3 attachment-full size-full wp-image-12117" alt="Intuitive user interface of the ENPICOM Platform" srcset="https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP.png 1111w, https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP-300x255.png 300w, https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP-1024x869.png 1024w, https://enpicom.com/wp-content/uploads/2024/11/Screen_1_EXP-768x652.png 768w" sizes="(max-width: 1111px) 100vw, 1111px" /></noscript> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-bc54b18 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="bc54b18" data-element_type="section"> <div class="elementor-container elementor-column-gap-default container mb-5 pb-lg-5 pb-md-4 pb-3"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ab6279f" data-id="ab6279f" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-c34c5da elementor-widget elementor-widget-highlighted-heading" data-id="c34c5da" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title h2 mb-lg-5 mb-4 pb-lg-0 pb-md-2 text-center"><span class="si-multipurpose-text__before">Benefits of humanization powered by ENPICOM</span></h2> </div> </div> <div class="elementor-element elementor-element-452cd25 elementor-widget elementor-widget-sn-imagebox-carousel" data-id="452cd25" data-element_type="widget" data-settings="{"effect":"slide","speed":500}" data-widget_type="sn-imagebox-carousel.imagebox-carousel"> <div class="elementor-widget-container"> <div data-swiper-options="{"spaceBetween":24,"pagination":{"el":".swiper-pagination","type":"bullets","clickable":true},"breakpoints":{"600":{"slidesPerView":3},"1000":{"slidesPerView":4}},"speed":500}" class="swiper sn-elementor-main-swiper mb-xl-3 "> <div class="swiper-wrapper"> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="rocket_launch_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/rocket_launch_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/rocket_launch_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="rocket_launch_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: ">High success rates </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Our deep learning model has proven to retain the binding affinity of parental antibodies exceptionally well, ensuring optimal outcomes for your therapeutic candidates.</p></div></div></div></div></div></div></div></div></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="finance_mode_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/finance_mode_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/finance_mode_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="finance_mode_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: ">Cost and time savings </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Express and screen fewer candidates while achieving higher humanization success rates, reducing both the time and cost associated with development.</p></div></div></div></div></div></div></div></div></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: ">Humanization forward </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>The combination of high success rates and a reduced number of variants to be screened enables the humanization of more candidates earlier in your research, accelerating the discovery process.</p></div></div></div></div></div></div></div></div></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="tune_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/tune_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/tune_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="tune_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: ">Flexible configuration </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><p>Customizable by design, our model allows you to modify default settings and add restrictions when needed, ensuring it always aligns with your research objectives.</p></div></div></div></div></div></div> </div> </div> </div> </div> <div class="swiper-pagination position-static mt-4 pt-lg-3 pt-2"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-d21cef1 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="d21cef1" data-element_type="section"> <div class="elementor-container elementor-column-gap-default container pt-5 mt-2 mt-md-4 mt-lg-5"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-23f6a2a" data-id="23f6a2a" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-79ef392 elementor-widget elementor-widget-highlighted-heading" data-id="79ef392" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title mb-4 border-bottom pb-4"><span class="silicon-elementor-highlighted-heading__highlighted-text text-gradient-primary">Case study: </span><span class="si-multipurpose-text__before">Achieving superior success rates compared to BioPhi</span></h2> </div> </div> <div class="elementor-section elementor-inner-section elementor-element elementor-element-02670fe elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="02670fe" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row pt-xl-3 row-margin"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e9d30f9 col-md-5 text-center text-md-start pb-5" data-id="e9d30f9" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-86914a2 elementor-widget elementor-widget-highlighted-heading" data-id="86914a2" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg mb-4"><span class="si-multipurpose-text__before">In collaboration with Genovac, a leading antibody discovery company, the ENPICOM model outperformed BioPhi in antibody humanization while maintaining high germline identity and superior binding affinity. Our model can humanize antibodies from any species and offers a selection of candidates for testing, where testing just 3-5 variants typically variants is sufficient to identify a high-affinity candidate, achieving clinically relevant humanness levels (>85% and >90% germline identity) and strong affinity retention similar to the parental clone. </span></p> </div> </div> <div class="elementor-element elementor-element-c5b424d mt-4 elementor-widget elementor-widget-button" data-id="c5b424d" data-element_type="widget" data-widget_type="button.button-silicon"> <div class="elementor-widget-container"> <a href="https://enpicom.com/webinar-discovery-characterization-and-generative-deep-learning-based-humanization-of-therapeutic-antibody-candidates/" class="silicon-button btn btn-outline-primary btn-lg w-sm-auto w-100 " role="button"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text silicon-button-text order-last">View the case study</span> </span> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3962d0a col-xl-6 col-md-7 offset-xl-1 pb-4 pb-sm-3 pb-lg-0 mb-4 mb-sm-5 mb-lg-0" data-id="3962d0a" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-ff5f6a5 elementor-widget elementor-widget-image" data-id="ff5f6a5" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="2709" height="1667" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%202709%201667'%3E%3C/svg%3E" class="rounded-3 attachment-full size-full wp-image-12122" alt="Case study: Achieving superior success rates compared to BioPhi" data-lazy-srcset="https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study.png 2709w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-300x185.png 300w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-1024x630.png 1024w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-768x473.png 768w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-1536x945.png 1536w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-2048x1260.png 2048w" data-lazy-sizes="(max-width: 2709px) 100vw, 2709px" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study.png" /><noscript><img loading="lazy" decoding="async" width="2709" height="1667" src="https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study.png" class="rounded-3 attachment-full size-full wp-image-12122" alt="Case study: Achieving superior success rates compared to BioPhi" srcset="https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study.png 2709w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-300x185.png 300w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-1024x630.png 1024w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-768x473.png 768w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-1536x945.png 1536w, https://enpicom.com/wp-content/uploads/2024/11/enpicom-biophi-case-study-2048x1260.png 2048w" sizes="(max-width: 2709px) 100vw, 2709px" /></noscript> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <div class="elementor-element elementor-element-67aac5a e-flex e-con-boxed e-con e-parent" data-id="67aac5a" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-c5b9845 elementor-widget elementor-widget-spacer" data-id="c5b9845" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> <section class="elementor-section elementor-top-section elementor-element elementor-element-7b93015b elementor-section-full_width container pb-5 mb-md-2 mb-lg-4 elementor-section-height-default elementor-section-height-default" data-id="7b93015b" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a354ef1" data-id="a354ef1" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-3ebd4080 elementor-widget elementor-widget-highlighted-heading" data-id="3ebd4080" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title"><span class="si-multipurpose-text__before">Getting started</span></h2> </div> </div> <div class="elementor-element elementor-element-7d816a8 elementor-widget elementor-widget-highlighted-heading" data-id="7d816a8" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg mb-4 mb-lg-4 border-bottom pb-4"><span class="si-multipurpose-text__before">We offer two customizable options, ensuring flexibility for your antibody humanization needs.</span></p> </div> </div> <div class="elementor-section elementor-inner-section elementor-element elementor-element-9fe0e61 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="9fe0e61" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row pt-2 pt-md-3 row-margin"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-14dde13b col-md-6" data-id="14dde13b" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7000ebb elementor-widget elementor-widget-highlighted-heading" data-id="7000ebb" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h3 class="silicon-elementor-highlighted-heading__title"><span class="si-multipurpose-text__before">Humanization as a service</span></h3> </div> </div> <div class="elementor-element elementor-element-7d1b331 elementor-widget elementor-widget-highlighted-heading" data-id="7d1b331" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg pe-lg-4 mb-1 mb-lg-4"><span class="si-multipurpose-text__before">Take the complexity out of antibody humanization with our dedicated team of experts. We handle every step of the process, from optimizing sequences to ensuring they are primed for further testing and development. <br> <br></span></p> </div> </div> <div class="elementor-element elementor-element-3d00d8e elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list" data-id="3d00d8e" data-element_type="widget" data-widget_type="icon-list.default"> <div class="elementor-widget-container"> <ul class="list-unstyled pb-2 mb-3 elementor-icon-list-items"> <li class="mb-2 pb-1 mt-0 elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check-circle"></i> </span> <span class="elementor-icon-list-text">Every project is personalized to your specific requirements.</span> </li> <li class="mb-2 pb-1 mt-0 elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check-circle"></i> </span> <span class="elementor-icon-list-text">Our team of scientists works with you to get a good selection of candidates.</span> </li> <li class="mb-2 pb-1 mt-0 elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check-circle"></i> </span> <span class="elementor-icon-list-text">Ideal for clients who humanize antibodies on a non-regular basis or appreciate expert oversight and guaranteed precision.</span> </li> </ul> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-61930f37 col-md-6" data-id="61930f37" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-9b2026c elementor-widget elementor-widget-highlighted-heading" data-id="9b2026c" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h3 class="silicon-elementor-highlighted-heading__title"><span class="si-multipurpose-text__before">Self-service humanization tool</span></h3> </div> </div> <div class="elementor-element elementor-element-10f708a elementor-widget elementor-widget-highlighted-heading" data-id="10f708a" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg pe-lg-4 mb-1 mb-lg-4"><span class="si-multipurpose-text__before">Empower your team to humanize antibodies independently with our easy-to-use humanization tool, controlling every step of the process yourself. <br><br></span></p> </div> </div> <div class="elementor-element elementor-element-1b34113 elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list" data-id="1b34113" data-element_type="widget" data-widget_type="icon-list.default"> <div class="elementor-widget-container"> <ul class="list-unstyled pb-2 mb-3 elementor-icon-list-items"> <li class="mb-2 pb-1 mt-0 elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check-circle"></i> </span> <span class="elementor-icon-list-text">Accelerate your humanization workflows by starting right after selecting your lead candidates.</span> </li> <li class="mb-2 pb-1 mt-0 elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check-circle"></i> </span> <span class="elementor-icon-list-text">Explore different strategies and experiment at your own pace, with full autonomy over the process.</span> </li> <li class="mb-2 pb-1 mt-0 elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check-circle"></i> </span> <span class="elementor-icon-list-text">Ideal for researchers who regularly conduct humanization campaigns and prefer hands-on control throughout the process.</span> </li> </ul> </div> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-e4a6971 mt-4 elementor-widget elementor-widget-button" data-id="e4a6971" data-element_type="widget" data-widget_type="button.button-silicon"> <div class="elementor-widget-container"> <a href="https://enpicom.com/services-form/" class="silicon-button btn btn-outline-primary btn-lg w-sm-auto w-100 " role="button"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text silicon-button-text order-last">Talk to our experts</span> </span> </a> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-f46deac elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="f46deac" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 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