A Real Step Forward: Brain-Spine Interface Allows Man to Walk Again

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Since then, he has been determined to find a way to walk again, and this goal has finally been achieved. In a paper published in late May, a research team from the Ecole Polytechnique Fédérale de Lausanne and NeuroRestore revealed that they had successfully developed a functional brain-spine interface (BSI) that has restored the functionality of Oskam’s legs.  </p>   <p>The accident cut off the pathway which allowed signals from the brain to reach the lumbar region of the spinal cord. This meant there were no instructions for nerve cells to transmit to the leg muscles. Even if the legs were otherwise completely healthy, they cannot move if this connection is not intact.   </p>   <p>The BSI reestablishes this severed connection by creating a “digital bridge” that enables communication between the brain and the region of the spinal cord that was not damaged in the accident. The brain-spine interface works using various implants in the brain and the spine. A pair of wireless implants surgically placed on either side of the brain’s sensorimotor cortex (the region which helps initiate movement) record the electrocorticographic signals, also known as cortical activity.   </p>   <ul> <li><a href="https://oxfordglobal.com/discovery/resources/applied-mobile-technologies-and-interfacing-with-robotics-software-developing-improved-approaches-for-cleanrooms/" target="_blank" rel="noreferrer noopener">Applied Mobile Technologies and Interfacing with Robotics Software</a></li>   <li><a href="https://oxfordglobal.com/discovery/resources/cellqualia-the-robot-changing-the-face-of-stem-cell-therapies/" target="_blank" rel="noreferrer noopener">CellQualia: The Robot Changing the Face of Stem Cell Therapies</a></li>   <li><a href="https://oxfordglobal.com/discovery/resources/robotic-surgery-pioneering-precision-in-medical-advancements/" target="_blank" rel="noreferrer noopener">Robotic Surgery: Pioneering Precision in Medical Advancements</a></li> </ul>   <p></p>   <p>To translate Oskam’s thoughts of movement into actual movement, the electrocorticographic signals must be sent via a portable processing unit worn as a backpack, which acts as the crucial “digital bridge." The processing unit converts the electrocorticographic signals into actual stimulation commands, which are then transferred to the spine implant (a pulse generator called the Activa RC, made by Medtronic). The spinal implant interprets the electrical currents and sends these to nerve cells in the spinal cord, activating the leg muscles and allowing movement.   </p>   <p>This breakthrough was made possible thanks to the researchers’ understanding of how to compensate for the loss of the brain-spine connection by harnessing the functionality of specific neurons, in this case, those which control the leg muscles. The researchers were even surprised by how quickly they could calibrate the first models of the BSI, with Oskam only needing seven minutes of training before he could walk naturally.   </p>   <p>Whilst other devices have given patients the ability to walk, none have allowed for entirely voluntary control; other types of spinal implant typically require the patient to initiate motion by pressing a button, which is not needed in this instance.   </p>   <p>Whilst there are still several limitations to the device, including how costly and bulky it is, there can be no doubt that it marks a huge step forward. In a press release, Grégoire Courtine, senior author of the paper, stated that “paralysis is the tip of the iceberg with spinal cord injury, as you have many other functions that are affected.”  </p>   <p>Equipped with the new information regarding device calibration that this trial provided, researchers are hopeful that in the coming years, they will be able to optimise the brain-spine interface for wider and more accessible usage.   </p>   <p><em>Get your weekly dose of industry news and announcements <a href="https://oxfordglobal.com/pharmatec/hub/?jsf=jet-engine&tax=resource_formats:322" target="_blank" rel="noreferrer noopener">here</a>, and keep up to date with the latest ‘Industry Spotlight’ posts. For other PharmaTec content, please visit the <a href="https://oxfordglobal.com/pharmatec/" target="_blank" rel="noreferrer noopener">PharmaTec Content Portal</a>.</em></p>   <p><em>Want to find out more about the innovations happening in pharma data? Join </em><a href="https://oxfordglobal.com/" target="_blank" rel="noreferrer noopener"><em>Oxford Global’s</em></a><em> annual <a href="https://oxfordglobal.com/pharmatec-series/" target="_blank" rel="noreferrer noopener">Pharma Data & Digital Medicine</a> event today. This 2-day conference brings together a panel of</em> <em>prominent leaders and scientists, sharing new case studies, innovative data, and exciting industry outlooks.</em></p>  <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/discovery-development/resources/ai-ml-advancements-in-drug-formulation-the-potential-of-self-driving-labs"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Formulation%20and%20Delivery/AI%20ML%20Advancements%20in%20Drug%20Formulation%20The%20Potential%20of%20Self-Driving%20Labs%20.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/discovery-development/resources/ai-ml-advancements-in-drug-formulation-the-potential-of-self-driving-labs"> <h4> AI/ML Advancements in Drug Formulation – The Potential of Self-Driving Labs </h4> <div class="abstract"> Intrepid Labs demonstrates how its self-driving lab uses ML and robotics to advance drug formulation. </div> <div class="read-more"> <a href="/discovery-development/resources/ai-ml-advancements-in-drug-formulation-the-potential-of-self-driving-labs" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/discovery-development/resources/euroscreen-fast-assay-development-and-high-throughput-screening-services"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Discovery/Euroscreen%20Fast%20Services.jpg" class="cover-graphic-image"> </div> </a><div class="content"><a href="/discovery-development/resources/euroscreen-fast-assay-development-and-high-throughput-screening-services"> <h4> Euroscreen Fast Assay Development and High-Throughput Screening Services </h4> <div class="abstract"> </div> <div class="read-more"> <a href="/discovery-development/resources/euroscreen-fast-assay-development-and-high-throughput-screening-services" class="read-more-link">Read More</a> </div></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="newsletter-cta"> <h2 class="heading">Subscribe to our newsletter</h2> <div class="message"> Sign up for our monthly Newsletter to keep up with all things Discovery & Development </div> <div class="button-wrapper"> <a href="#" class="button hs-cta-trigger-button hs-cta-trigger-button-177049184347">Newsletter Sign-Up</a> </div> </div> </main> <div data-global-resource-path="git/og-stage/templates/partials/footer.html"><footer class="website-footer flex flex-column g-20"> <div class="footer-columns"> <div class="footer-column"> <a href="https://oxfordglobal.com" class="site-logo-link"> <img src="https://oxfordglobal.com/wp-content/uploads/2023/03/Oxford-Global-Logo-Stacked-Websize.png" class="site-logo"> </a> </div> <div class="footer-column"> <h3>Brands</h3> <ul> <li> <a href="/precision-medicine/">Precision Medicine</a> </li> <li> <a href="/discovery-development/">Discovery & Development</a> </li> <li> <a href="/nextgen-biomed/">NextGen Biomed</a> </li> </ul> </div> <div class="footer-column"> <h3>Services</h3> <ul> <li> <a href="https://oxfordglobal.com/in-person-services/"> In-Person Services </a> </li> <li> <a href="https://oxfordglobal.com/digital-marketing-services/"> Digital Marketing Services </a> </li> </ul> <h3>Upcoming Events</h3> <ul> <li> <a href="https://oxfordglobal.com/calendar/"> Event Calendar </a> </li> </ul> </div> <div class="footer-column"> <h3>Company</h3> <ul> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/about-us/"> About </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/vacancies/"> Vacancies </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/csr-policy/"> CSR Policy </a> </li> <li class="elementor-icon-list-item"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});"> Contact </a> </li> </ul> </div> <div class="footer-column"> <p> <a href="tel:+441865248455">+44 1865 248 455</a><br> <a href="mailto:help@oxfordglobal.com">help@oxfordglobal.com</a> </p> <p> <strong>Our UK Address:</strong><br> Godstow Court<br> Minns Business Park<br> Botley<br> Oxford, OX2 0JB </p> <p> <strong>Our US Address:</strong><br> 100 Cambridge Street<br> 14th Floor<br> Boston<br> MA 02114 </p> </div> </div> <div class="footer-bottom grid g-20"> <div class="span8 span12-sm span12-md flex flex-column g-10"> <div class="copyright"> © Oxford Global Marketing Ltd. 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A Real Step Forward: Brain-Spine Interface Allows Man to Walk Again