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KEGG REACTION: R05459
<!doctype html> <html><head> <title>KEGG REACTION: R05459</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1745284820"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1745284820"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1745284820" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; 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} } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="675"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg2.gif"></a></td><td> </td><td><a name="reaction:R05459"></a><font class="title2">REACTION: R05459</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_reaction.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr2 w1"> <table width="650" class="w2"> <tr><th class="th20 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td20 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">R05459 Reaction <br> </span></code></td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td21 defd"><div class="cel"><div class="cel">tetracycline:coenzyme-F420 oxidoreductase<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Definition</span></th> <td class="td20 defd"><div class="cel"><div class="cel">Tetracycline + Coenzyme F420 <=> 5a,11a-Dehydrotetracycline + Reduced coenzyme F420<br> </div></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Equation</span></th> <td class="td21 defd"><div class="cel"><a href="/entry/C06570">C06570</a> + <a href="/entry/C00876">C00876</a> <=> <a href="/entry/C03206">C03206</a> + <a href="/entry/C01080">C01080</a><br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap"></span></th> <td class="td20 defd"><a href="/Fig/reaction/R05459.gif"><img border=0 name="img0" align="bottom" src="/Fig/reaction/R05459.gif" style="max-width:600px"></a></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reaction class</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/RC01925">RC01925</a> </span></td><td>C03206_C06570</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Enzyme</span></th> <td class="td20 defd"><div class="cel"><a href="/entry/1.3.98.4">1.3.98.4</a><br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/rn00253+R05459">rn00253</a> </span></td><td>Tetracycline biosynthesis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/rn01057+R05459">rn01057</a> </span></td><td>Biosynthesis of type II polyketide products</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/rn01100+R05459">rn01100</a> </span></td><td>Metabolic pathways</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/rn01110+R05459">rn01110</a> </span></td><td>Biosynthesis of secondary metabolites</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Module</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00780+R05459">M00780</a> </span></td><td>Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00823+R05459">M00823</a> </span></td><td>Chlortetracycline biosynthesis, pretetramide => chlortetracycline</td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td21 defd"><div class="cel"><span class="nowrap">Enzymatic reactions [BR:<a href="/brite/br08201+R05459">br08201</a>]<br> 1. Oxidoreductase reactions<br> 1.3 Acting on the CH-CH group of donors<br> 1.3.98 With other, known, physiological acceptors<br> 1.3.98.4<br> R05459 Tetracycline + Coenzyme F420 <=> 5a,11a-Dehydrotetracycline + Reduced coenzyme F420<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=R05459';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K21301">K21301</a> </span></td><td>5a,11a-dehydrotetracycline reductase [EC:<a href="/entry/1.3.98.4">1.3.98.4</a>]</td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">1 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/23621493">23621493</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td20 repd"><div class="cel">Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td21 repd"><div class="cel">Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td20 repd"><div class="cel">J Am Chem Soc 135:7138-41 (2013)<br>DOI:<a href="https://doi.org/10.1021/ja403516u">10.1021/ja403516u</a></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">RHEA: </span></td><td><a href="https://www.rhea-db.org/reaction?id=50387">50387</a></td></tr></table></td></tr> <tr><th class="th20 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td20 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?reaction+R05459';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>