Maternal metabolic factors and early-onset puberty: Kaiser Permanente study the largest population-based research on topic -- ScienceDaily

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Early puberty has been linked to multiple adverse health developments as girls grow up. </dd> <dt class="no-print">Share:</dt> <dd class="no-print"> <div id="share_top"> <div data-url="https://web.archive.org/web/20190402162431oe_/https://www.sciencedaily.com/releases/2018/04/180416085953.htm" class="ssk-sm ssk-group"> <a class="ssk ssk-icon ssk-facebook"></a> <a class="ssk ssk-icon ssk-twitter"></a> <a class="ssk ssk-icon ssk-google-plus"></a> <a class="ssk ssk-icon ssk-pinterest"></a> <a class="ssk ssk-icon ssk-linkedin"></a> <a class="ssk ssk-icon ssk-email"></a> </div> </div> </dd> </dl> <div class="row"> <div class="col-md-8 col-md-push-4"> <div class="fullstory">FULL STORY</div> <hr class="hr-fullstory"/>  <div class="clearfix"></div> <div id="story_text" class="hyphenate less-top-margin"> <p id="first" class="lead">In a study of more than 15,000 girls and their mothers -- all Kaiser Permanente members in Northern California -- maternal overweight and hyperglycemia were linked to the earlier onset of puberty in girls 6 to 11 years old. Early puberty has been linked to multiple adverse health developments as girls grow up.</p> <div class="mobile-top-rectangle hidden-md hidden-lg"> <div class="textrule"> <span>advertisement</span> </div>  <div id="adslot-mobile-top-rectangle"> <script type="text/javascript"> googletag.cmd.push(function() { deployads.push(function() { deployads.gpt.display("adslot-mobile-top-rectangle") }); }); </script> </div> <hr class="hrrule"/> </div> <div id="text"> <p>The study, "Associations between maternal obesity and pregnancy hyperglycemia and timing of pubertal onset in adolescent girls: A population-based study," was published today in <em>American Journal of Epidemiology</em>. The girls in the study were from diverse cultures and ethnicities.</p> <p>"We know that maternal weight can influence childhood weight. What we are learning is that the in utero environment may also affect the timing of future pubertal development in offspring, which makes sense since human brains are developed in utero and the brain releases hormones affecting puberty," said lead author Ai Kubo, MPH, PhD, research scientist with the Kaiser Permanente Northern California Division of Research.</p> <p>This research builds on previous Kaiser Permanente research that demonstrated earlier onset of puberty in American girls, as well as the possible role of environmental, perinatal and other risk factors. Early puberty, including the early onset of breast development or menarche (initiation of menstruation), increases the risk of adverse health outcomes including obesity, type 2 diabetes, polycystic ovarian syndrome, and cancer in adolescence and adulthood. For girls, it has been linked to a higher risk of adverse emotional and behavioral outcomes including depression, anxiety, earlier sexual initiation and pregnancy.</p> <p>In 2010, Kaiser Permanente pediatricians in Northern California began routinely documenting Tanner stages, a standardized measure of pubertal development, in electronic health records during routine pediatric exams. This study is the largest to link the Tanner-stage measurements of girls with the medical records of their mothers in order to assess the role of pregnancy-related factors on pubertal timing.</p> <p>Researchers found that maternal obesity (body mass index of 30 or more) and overweight (body mass index between 25 and 30) in mothers was associated with 40 percent and 20 percent greater chance of earlier breast development in girls, respectively. The study also found a 7-month difference in onset of breast development in daughters of obese versus underweight mothers.</p> <p>For pubic hair development, similar associations between maternal obesity and earlier onset were found. However, the data suggest that the associations may differ by race and ethnicity. For instance, Asian girls with obese mothers were 50 percent more likely to experience earlier onset of pubic hair than Asian girls with normal-weight mothers, while there were no associations among African-American girls.</p> <p>The study also found a significant relationship between hyperglycemia (elevated blood sugar during pregnancy) in mothers and the earlier onset of breast development, but not in mothers with gestational diabetes.</p> <p>"It's possible that women with the diagnosis of gestational diabetes were more careful about weight and diet, which might have changed the amount of weight gain and offspring development patterns, but other studies need to replicate the finding to be able to conclude that there is an association," Kubo noted.</p> <p>Senior author Lawrence H. Kushi, ScD, research scientist with the Division of Research, said the study provides new avenues for slowing the trend toward earlier sexual maturation in girls. "Understanding the intergenerational effects of in utero exposures is helping health care systems such as Kaiser Permanente to develop new strategies for assisting women to manage weight and hyperglycemia before and during pregnancy, not only for their own health, but also for that of their children."</p> </div> <div class="mobile-middle-rectangle hidden-md hidden-lg"> <div class="textrule"> <span>advertisement</span> </div>  <div id="adslot-mobile-middle-rectangle"> <script type="text/javascript"> googletag.cmd.push(function() { deployads.push(function() { deployads.gpt.display("adslot-mobile-middle-rectangle") }); }); </script> </div> <hr class="hrrule"/> </div> <hr class="hidden-sm hidden-xs"/> <div id="story_source"> <p><strong>Story Source:</strong></p> <p>Materials provided by <a href="https://web.archive.org/web/20190402162431/http://share.kaiserpermanente.org/" rel="nofollow" target="_blank"><strong>Kaiser Permanente</strong></a>. <em>Note: Content may be edited for style and length.</em></p> </div>  <hr/> <div id="journal_references"><p><strong>Journal Reference</strong>:</p> <ol class="journal"> <li>Ai Kubo, Julianna Deardorff, Cecile A Laurent, Assiamira Ferrara, Louise C Greenspan, Charles P Quesenberry, Lawrence H Kushi. <strong>Associations Between Maternal Obesity and Pregnancy Hyperglycemia and Timing of Puberty Onset in Adolescent Girls: A Population-Based Study</strong>. <em>American Journal of Epidemiology</em>, 2018; DOI: <a href="https://web.archive.org/web/20190402162431/http://dx.doi.org/10.1093/aje/kwy040" rel="nofollow" target="_blank">10.1093/aje/kwy040</a> </li> </ol> <hr/> </div>  <div id="citations"> <div role="tabpanel" class="right-tabs clearfix"> <p class="pull-left"><strong>Cite This Page</strong>:</p>  <ul class="nav nav-tabs" role="tablist"> <li role="presentation" class="active"><a href="#citation_mla" aria-controls="citation_mla" role="tab" data-toggle="tab">MLA</a></li> <li role="presentation"><a href="#citation_apa" aria-controls="citation_apa" role="tab" data-toggle="tab">APA</a></li> <li role="presentation"><a href="#citation_chicago" aria-controls="citation_chicago" role="tab" data-toggle="tab">Chicago</a></li> </ul> <div class="tab-content tab-citations"> <div role="tabpanel" class="tab-pane active" id="citation_mla">Kaiser Permanente. "Maternal metabolic factors and early-onset puberty: Kaiser Permanente study the largest population-based research on topic." ScienceDaily. ScienceDaily, 16 April 2018. <www.sciencedaily.com/releases/2018/04/180416085953.htm>.</div> <div role="tabpanel" class="tab-pane" id="citation_apa">Kaiser Permanente. (2018, April 16). Maternal metabolic factors and early-onset puberty: Kaiser Permanente study the largest population-based research on topic. <em>ScienceDaily</em>. Retrieved April 1, 2019 from www.sciencedaily.com/releases/2018/04/180416085953.htm</div> <div role="tabpanel" class="tab-pane" id="citation_chicago">Kaiser Permanente. "Maternal metabolic factors and early-onset puberty: Kaiser Permanente study the largest population-based research on topic." 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Maternal metabolic factors and early-onset puberty: Kaiser Permanente study the largest population-based research on topic -- ScienceDaily