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spectrometry</title> <meta name="description" content="Search results for: Tandem mass spectrometry"> <meta name="keywords" content="Tandem mass spectrometry"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Tandem mass spectrometry"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3787</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Tandem mass spectrometry</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3787</span> New Method for the Determination of Montelukast in Human Plasma by Solid Phase Extraction Using Liquid Chromatography Tandem Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vijayalakshmi%20Marella">Vijayalakshmi Marella</a>, <a href="https://publications.waset.org/abstracts/search?q=NageswaraRaoPilli"> NageswaraRaoPilli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper describes a simple, rapid and sensitive liquid chromatography / tandem mass spectrometry assay for the determination of montelukast in human plasma using montelukast d6 as an internal standard. Analyte and the internal standard were extracted from 50 µL of human plasma via solid phase extraction technique without evaporation, drying and reconstitution steps. The chromatographic separation was achieved on a C18 column by using a mixture of methanol and 5mM ammonium acetate (80:20, v/v) as the mobile phase at a flow rate of 0.8 mL/min. Good linearity results were obtained during the entire course of validation. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.5 min for each sample made it possible to analyze more number of samples in short time, thus increasing the productivity. The proposed method was found to be applicable to clinical studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Montelukast" title="Montelukast">Montelukast</a>, <a href="https://publications.waset.org/abstracts/search?q=tandem%20mass%20spectrometry" title=" tandem mass spectrometry"> tandem mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=montelukast%20d6" title=" montelukast d6"> montelukast d6</a>, <a href="https://publications.waset.org/abstracts/search?q=FDA%20guidelines" title=" FDA guidelines"> FDA guidelines</a> </p> <a href="https://publications.waset.org/abstracts/29304/new-method-for-the-determination-of-montelukast-in-human-plasma-by-solid-phase-extraction-using-liquid-chromatography-tandem-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29304.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">315</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3786</span> Comprehending the Relationship between the Red Blood Cells of a Protein 4.1 -/- Patient and Those of Healthy Controls: A Comprehensive Analysis of Tandem Mass Spectrometry Data</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20M.%20Hjazi">Ahmed M. Hjazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Bader%20M.%20Hjazi"> Bader M. Hjazi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Protein 4.1 is a crucial component of complex interactions between the cytoskeleton and other junctional complex proteins. When the gene encoding this protein is altered, resulting in reduced expression, or when the protein is absent, the red cell undergoes a significant structural change. This research aims to achieve a deeper comprehension of the biochemical effects of red cell protein deficiency. A Tandem Mass Spectrometry Analysis (TMT-MS/MS) of patient cells lacking protein 4.1 compared to three healthy controls was achieved by the Proteomics Institute of the University of Bristol. The SDS-PAGE and Western blotting were utilized on the original patient sample and controls to partially confirm TMT MS/MS data analysis of the protein-4.1-deficient cells. Compared to healthy controls, protein levels in samples lacking protein 4.1 had a significantly higher concentration of proteins that probably originated from reticulocytes. This could occur if the patient has an elevated reticulocyte count. The increase in chaperone and reticulocyte-associated proteins was most notable in this study. This may result from elevated quantities of reticulocytes in patients with hereditary elliptocytosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hereditary%20elliptocytosis" title="hereditary elliptocytosis">hereditary elliptocytosis</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%204.1" title=" protein 4.1"> protein 4.1</a>, <a href="https://publications.waset.org/abstracts/search?q=red%20cells" title=" red cells"> red cells</a>, <a href="https://publications.waset.org/abstracts/search?q=tandem%20mass%20spectrometry%20data." title=" tandem mass spectrometry data."> tandem mass spectrometry data.</a> </p> <a href="https://publications.waset.org/abstracts/165174/comprehending-the-relationship-between-the-red-blood-cells-of-a-protein-41-patient-and-those-of-healthy-controls-a-comprehensive-analysis-of-tandem-mass-spectrometry-data" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165174.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">79</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3785</span> Multiclass Analysis of Pharmaceuticals in Fish and Shrimp Tissues by High-Performance Liquid Chromatography-Tandem Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Reza%20Pashaei">Reza Pashaei</a>, <a href="https://publications.waset.org/abstracts/search?q=Reda%20Dzingelevi%C4%8Dien%C4%97"> Reda Dzingelevičienė</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An efficient, reliable, and sensitive multiclass analytical method has been expanded to simultaneously determine 15 human pharmaceutical residues in fish and shrimp tissue samples by ultra-high-performance liquid chromatography-tandem mass spectrometry. The investigated compounds comprise ten classes, namely analgesic, antibacterial, anticonvulsant, cardiovascular, fluoroquinolones, macrolides, nonsteroidal anti-inflammatory, penicillins, stimulant, and sulfonamide. A simple liquid extraction procedure based on 0.1% formic acid in methanol was developed. Chromatographic conditions were optimized, and mobile phase namely 0.1 % ammonium acetate (A), and acetonitrile (B): 0 – 2 min, 15% B; 2 – 5 min, linear to 95% B; 5 – 10 min, 95% B; and 10 – 12 min was obtained. Limits of detection and quantification ranged from 0.017 to 1.371 μg/kg and 0.051 to 4.113 μg/kg, respectively. Finally, amoxicillin, azithromycin, caffeine, carbamazepine, ciprofloxacin, clarithromycin, diclofenac, erythromycin, furosemide, ibuprofen, ketoprofen, naproxen, sulfamethoxazole, tetracycline, and triclosan were quantifiable in fish and shrimp samples. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fish" title="fish">fish</a>, <a href="https://publications.waset.org/abstracts/search?q=liquid%20chromatography" title=" liquid chromatography"> liquid chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmaceuticals" title=" pharmaceuticals"> pharmaceuticals</a>, <a href="https://publications.waset.org/abstracts/search?q=shrimp" title=" shrimp"> shrimp</a>, <a href="https://publications.waset.org/abstracts/search?q=solid-phase%20extraction" title=" solid-phase extraction"> solid-phase extraction</a> </p> <a href="https://publications.waset.org/abstracts/143257/multiclass-analysis-of-pharmaceuticals-in-fish-and-shrimp-tissues-by-high-performance-liquid-chromatography-tandem-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143257.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">262</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3784</span> Structural Elucidation of Intact Rough-Type Lipopolysaccharides using Field Asymmetric Ion Mobility Spectrometry and Kendrick Mass Defect Plots</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abanoub%20Mikhael">Abanoub Mikhael</a>, <a href="https://publications.waset.org/abstracts/search?q=Darryl%20Hardie"> Darryl Hardie</a>, <a href="https://publications.waset.org/abstracts/search?q=Derek%20Smith"> Derek Smith</a>, <a href="https://publications.waset.org/abstracts/search?q=Helena%20Petrosova"> Helena Petrosova</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20Ernst"> Robert Ernst</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Goodlett"> David Goodlett</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lipopolysaccharide (LPS) is a hallmark virulence factor of Gram-negative bacteria. It is a complex, structurally het- erogeneous mixture due to variations in number, type, and position of its simplest units: fatty acids and monosaccharides. Thus, LPS structural characterization by traditional mass spectrometry (MS) methods is challenging. Here, we describe the benefits of field asymmetric ion mobility spectrometry (FAIMS) for analysis of intact R-type lipopolysaccharide complex mixture (lipooligo- saccharide; LOS). Structural characterization was performed using Escherichia coli J5 (Rc mutant) LOS, a TLR4 agonist widely used in glycoconjugate vaccine research. FAIMS gas phase fractionation improved the (S/N) ratio and number of detected LOS species. Additionally, FAIMS allowed the separation of overlapping isobars facilitating their tandem MS characterization and un- equivocal structural assignments. In addition to FAIMS gas phase fractionation benefits, extra sorting of the structurally related LOS molecules was further accomplished using Kendrick mass defect (KMD) plots. Notably, a custom KMD base unit of [Na-H] created a highly organized KMD plot that allowed identification of interesting and novel structural differences across the different LOS ion families, i.e., ions with different acylation degrees, oligosaccharides composition, and chemical modifications. Defining the composition of a single LOS ion by tandem MS along with the organized KMD plot structural network was sufficient to deduce the composition of 181 LOS species out of 321 species present in the mixture. The combination of FAIMS and KMD plots allowed in-depth characterization of the complex LOS mixture and uncovered a wealth of novel information about its structural variations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lipopolysaccharide" title="lipopolysaccharide">lipopolysaccharide</a>, <a href="https://publications.waset.org/abstracts/search?q=ion%20mobility%20MS" title=" ion mobility MS"> ion mobility MS</a>, <a href="https://publications.waset.org/abstracts/search?q=Kendrick%20mass%20defect" title=" Kendrick mass defect"> Kendrick mass defect</a>, <a href="https://publications.waset.org/abstracts/search?q=Tandem%20mass%20spectrometry" title=" Tandem mass spectrometry"> Tandem mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/173086/structural-elucidation-of-intact-rough-type-lipopolysaccharides-using-field-asymmetric-ion-mobility-spectrometry-and-kendrick-mass-defect-plots" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/173086.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">71</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3783</span> Aflatoxins Characterization in Remedial Plant-Delphinium denudatum by High-Performance Liquid Chromatography–Tandem Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nadeem%20A.%20Siddique">Nadeem A. Siddique</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohd%20Mujeeb"> Mohd Mujeeb</a>, <a href="https://publications.waset.org/abstracts/search?q=Kahkashan"> Kahkashan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The objective of the projected work is to study the occurrence of the aflatoxins B1, B2, G1and G2 in remedial plants, exclusively in Delphinium denudatum. The aflatoxins were analysed by high-performance liquid chromatography–tandem quadrupole mass spectrometry with electrospray ionization (HPLC–MS/MS) and immunoaffinity column chromatography were used for extraction and purification of aflatoxins. PDA media was selected for fungal count. Results: A good quality linear relationship was originated for AFB1, AFB2, AFG1 and AFG2 at 1–10 ppb (r > 0.9995). The analyte precision at three different spiking levels was 88.7–109.1 %, by means of low per cent relative standard deviations in each case. Within 5 to7 min aflatoxins can be separated using an Agilent XDB C18-column. We found that AFB1 and AFB2 were not found in D. denudatum. This was reliable through exceptionally low figures of fungal colonies observed after 6 hr of incubation. The developed analytical method is straightforward, be successfully used to determine the aflatoxins. Conclusion: The developed analytical method is straightforward, simple, accurate, economical and can be successfully used to find out the aflatoxins in remedial plants and consequently to have power over the quality of products. The presence of aflatoxin in the plant extracts was interrelated to the least fungal load in the remedial plants examined. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aflatoxins" title="aflatoxins">aflatoxins</a>, <a href="https://publications.waset.org/abstracts/search?q=delphinium%20denudatum" title=" delphinium denudatum"> delphinium denudatum</a>, <a href="https://publications.waset.org/abstracts/search?q=liquid%20chromatography" title=" liquid chromatography"> liquid chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/56463/aflatoxins-characterization-in-remedial-plant-delphinium-denudatum-by-high-performance-liquid-chromatography-tandem-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56463.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">213</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3782</span> Determination of a Novel Artificial Sweetener Advantame in Food by Liquid Chromatography Tandem Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fangyan%20Li">Fangyan Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Lin%20Min%20Lee"> Lin Min Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Hui%20Zhu%20Peh"> Hui Zhu Peh</a>, <a href="https://publications.waset.org/abstracts/search?q=Shoet%20Harn%20Chan"> Shoet Harn Chan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Advantame, a derivative of aspartame, is the latest addition to a family of low caloric and high potent dipeptide sweeteners which include aspartame, neotame and alitame. The use of advantame as a high-intensity sweetener in food was first accepted by Food Standards Australia New Zealand in 2011 and subsequently by US and EU food authorities in 2014, with the results from toxicity and exposure studies showing advantame poses no safety concern to the public at regulated levels. To our knowledge, currently there is barely any detailed information on the analytical method of advantame in food matrix, except for one report published in Japanese, stating a high performance liquid chromatography (HPLC) and liquid chromatography/ mass spectrometry (LC-MS) method with a detection limit at ppm level. However, the use of acid in sample preparation and instrumental analysis in the report raised doubt over the reliability of the method, as there is indication that stability of advantame is compromised under acidic conditions. Besides, the method may not be suitable for analyzing food matrices containing advantame at low ppm or sub-ppm level. In this presentation, a simple, specific and sensitive method for the determination of advantame in food is described. The method involved extraction with water and clean-up via solid phase extraction (SPE) followed by detection using liquid chromatography tandem mass spectrometry (LC-MS/MS) in negative electrospray ionization mode. No acid was used in the entire procedure. Single laboratory validation of the method was performed in terms of linearity, precision and accuracy. A low detection limit at ppb level was achieved. Satisfactory recoveries were obtained using spiked samples at three different concentration levels. This validated method could be used in the routine inspection of the advantame level in food. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=advantame" title="advantame">advantame</a>, <a href="https://publications.waset.org/abstracts/search?q=food" title=" food"> food</a>, <a href="https://publications.waset.org/abstracts/search?q=LC-MS%2FMS" title=" LC-MS/MS"> LC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=sweetener" title=" sweetener"> sweetener</a> </p> <a href="https://publications.waset.org/abstracts/26887/determination-of-a-novel-artificial-sweetener-advantame-in-food-by-liquid-chromatography-tandem-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26887.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">475</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3781</span> Parabens, Paraben Metabolites and Triclocarban in Sediment Samples from the Trondheim Fjord, Norway</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kristine%20Vike-Jonas">Kristine Vike-Jonas</a>, <a href="https://publications.waset.org/abstracts/search?q=Susana%20V.%20Gonzalez"> Susana V. Gonzalez</a>, <a href="https://publications.waset.org/abstracts/search?q=Olav%20L.%20Bakkerud"> Olav L. Bakkerud</a>, <a href="https://publications.waset.org/abstracts/search?q=Karoline%20S.%20Gjelstad"> Karoline S. Gjelstad</a>, <a href="https://publications.waset.org/abstracts/search?q=Shazia%20N.%20Aslam"> Shazia N. Aslam</a>, <a href="https://publications.waset.org/abstracts/search?q=%C3%98yvind%20Mikkelsen"> Øyvind Mikkelsen</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexandros%20Asimakopoulos"> Alexandros Asimakopoulos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> P-hydrobenzoic acid esters (parabens), paraben metabolites, and triclocarban (TCC) are a group of synthetic antimicrobials classified as endocrine disrupting chemicals (EDCs) and emerging pollutants. The aim of this study was to investigate the levels of these compounds in sediment near the effluent of a wastewater treatment plant (WWTP) in the Trondheim Fjord, Norway. Paraben, paraben metabolites, and TCC are high volume production chemicals that are found in a range of consumer products, especially pharmaceuticals and personal care products (PCPs). In this study, six parabens (methyl paraben; MeP, ethyl paraben; EtP, propyl paraben; PrP, butyl paraben; BuP, benzyl paraben; BezP, heptyl paraben; HeP), four paraben metabolites (4-hydroxybenzoic acid; 4-HB, 3,4-dihydroxybenzoic acid; 3,4-DHB, methyl protocatechuic acid; OH-MeP, ethyl protocatechuic acid; OH-EtP) and TCC were determined by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in 64 sediment samples from 10 different locations outside Trondheim, Norway. Of these 11 target analytes, four were detected in 40 % or more of the samples. The sum of six parabens (∑Parabens), four paraben metabolites (∑Metabolites) and TCC in sediment ranged from 4.88 to 11.56 (mean 6.81) ng/g, 52.16 to 368.28 (mean 93.89) ng/g and 0.53 to 3.65 (mean 1.50) ng/g dry sediment, respectively. Pearson correlation coefficients indicated that TCC was positively correlated with OH-MeP, but negatively correlated with 4-HB. To the best of the author’s knowledge, this is the first time parabens, paraben metabolites and TCC have been reported in the Trondheim Fjord. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=parabens" title="parabens">parabens</a>, <a href="https://publications.waset.org/abstracts/search?q=liquid%20chromatography" title=" liquid chromatography"> liquid chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=sediment" title=" sediment"> sediment</a>, <a href="https://publications.waset.org/abstracts/search?q=tandem%20mass%20spectrometry" title=" tandem mass spectrometry"> tandem mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/113904/parabens-paraben-metabolites-and-triclocarban-in-sediment-samples-from-the-trondheim-fjord-norway" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/113904.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">129</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3780</span> Underivatized Amino Acid Analyses Using Liquid Chromatography-Tandem Mass Spectrometry in Scalp Hair of Children with Autism Spectrum Disorder</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ayat%20Bani%20Rashaid">Ayat Bani Rashaid</a>, <a href="https://publications.waset.org/abstracts/search?q=Zain%20Khasawneh"> Zain Khasawneh</a>, <a href="https://publications.waset.org/abstracts/search?q=Mazin%20Alqhazo"> Mazin Alqhazo</a>, <a href="https://publications.waset.org/abstracts/search?q=Shreen%20Nusair"> Shreen Nusair</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20El-Khateeb"> Mohammad El-Khateeb</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20Bashtawi"> Mahmoud Bashtawi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Autism Spectrum disorder (ASD) is a psychiatric disorder with unknown etiology that mainly affects children in the first three years of life. Alterations of amino acid levels are believed to contribute to ASD. The levels of six essential amino acids (methionine, histidine, valine, leucine, threonine, and phenylalanine), five conditional amino acids (proline, tyrosine, glutamine, cysteine, and cystine), and five non-essential amino acids (asparagine, aspartic acid, alanine, serine, and glutamic acid) in hair samples of children with ASD (n = 25) were analyzed and compared to corresponding levels in healthy age-matched controls (n = 25). The results showed that the levels of methionine, alanine, and asparagine were significantly lower in the hair samples of ASD group compared to those of the control group (p ≤ 0.05). However, the levels of glutamic acid were significantly higher in the ASD group than the control group (p ≤ 0.05). The current findings could contribute towards further understanding of ASD etiology and provide specialists with a hair amino acid profile utilized as a biomarker for early diagnosis of ASD. Such biomarkers could participate in future developments of therapies that reduce ASD-related symptoms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autism%20spectrum%20disorder" title="autism spectrum disorder">autism spectrum disorder</a>, <a href="https://publications.waset.org/abstracts/search?q=amino%20acids" title=" amino acids"> amino acids</a>, <a href="https://publications.waset.org/abstracts/search?q=liquid%20chromatography-tandem%20mass%20spectrometry" title=" liquid chromatography-tandem mass spectrometry"> liquid chromatography-tandem mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20hair" title=" human hair"> human hair</a> </p> <a href="https://publications.waset.org/abstracts/128805/underivatized-amino-acid-analyses-using-liquid-chromatography-tandem-mass-spectrometry-in-scalp-hair-of-children-with-autism-spectrum-disorder" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/128805.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">138</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3779</span> Gas Chromatography Coupled to Tandem Mass Spectrometry and Liquid Chromatography Coupled to Tandem Mass Spectrometry Qualitative Determination of Pesticides Found in Tea Infusions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mihai-Alexandru%20Florea">Mihai-Alexandru Florea</a>, <a href="https://publications.waset.org/abstracts/search?q=Veronica%20Drumea"> Veronica Drumea</a>, <a href="https://publications.waset.org/abstracts/search?q=Roxana%20Nita"> Roxana Nita</a>, <a href="https://publications.waset.org/abstracts/search?q=Cerasela%20Gird"> Cerasela Gird</a>, <a href="https://publications.waset.org/abstracts/search?q=Laura%20Olariu"> Laura Olariu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to investigate the residues of pesticide found in tea water infusions. A multi-residues method to determine 147 pesticides has been developed using the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) procedure and dispersive solid phase extraction (d-SPE) for the cleanup the pesticides from complex matrices such as plants and tea. Sample preparation was carefully optimized for the efficient removal of coextracted matrix components by testing more solvent systems. Determination of pesticides was performed using GC-MS/MS (100 of pesticides) and LC-MS/MS (47 of pesticides). The selected reaction monitoring (SRM) mode was chosen to achieve low detection limits and high compounds selectivity and sensitivity. Overall performance was evaluated and validated according to DG-SANTE Guidelines. To assess the pesticide residue transfer rate (qualitative) from dried tea in infusions the samples (tea) were spiked with a mixture of pesticides at the maximum residues level accepted for teas and herbal infusions. In order to investigate the release of the pesticides in tea preparations, the medicinal plants were prepared in four ways by variation of water temperature and the infusion time. The pesticides from infusions were extracted using two methods: QuEChERS versus solid-phase extraction (SPE). More that 90 % of the pesticides studied was identified in infusion. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tea" title="tea">tea</a>, <a href="https://publications.waset.org/abstracts/search?q=solid-phase%20extraction%20%28SPE%29" title=" solid-phase extraction (SPE)"> solid-phase extraction (SPE)</a>, <a href="https://publications.waset.org/abstracts/search?q=selected%20reaction%20monitoring%20%28SRM%29" title=" selected reaction monitoring (SRM)"> selected reaction monitoring (SRM)</a>, <a href="https://publications.waset.org/abstracts/search?q=QuEChERS" title=" QuEChERS"> QuEChERS</a> </p> <a href="https://publications.waset.org/abstracts/70223/gas-chromatography-coupled-to-tandem-mass-spectrometry-and-liquid-chromatography-coupled-to-tandem-mass-spectrometry-qualitative-determination-of-pesticides-found-in-tea-infusions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/70223.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">213</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3778</span> A Plasmonic Mass Spectrometry Approach for Detection of Small Nutrients and Toxins</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Haiyang%20Su">Haiyang Su</a>, <a href="https://publications.waset.org/abstracts/search?q=Kun%20Qian"> Kun Qian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We developed a novel plasmonic matrix assisted laser desorption/ionization mass spectrometry (MALDI MS) approach to detect small nutrients and toxin in complex biological emulsion samples. We used silver nanoshells (SiO₂@Ag) with optimized structures as matrices and achieved direct analysis of ~6 nL of human breast milk without any enrichment or separation. We performed identification and quantitation of small nutrients and toxins with limit-of-detection down to 0.4 pmol (for melamine) and reaction time shortened to minutes, superior to the conventional biochemical methods currently in use. Our approach contributed to the near-future application of MALDI MS in a broad field and personalized design of plasmonic materials for real case bio-analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=plasmonic%20materials" title="plasmonic materials">plasmonic materials</a>, <a href="https://publications.waset.org/abstracts/search?q=laser%20desorption%2Fionization" title=" laser desorption/ionization"> laser desorption/ionization</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=small%20nutrients" title=" small nutrients"> small nutrients</a>, <a href="https://publications.waset.org/abstracts/search?q=toxins" title=" toxins"> toxins</a> </p> <a href="https://publications.waset.org/abstracts/90310/a-plasmonic-mass-spectrometry-approach-for-detection-of-small-nutrients-and-toxins" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/90310.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">211</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3777</span> Determination of Marbofloxacin in Pig Plasma Using LC-MS/MS and Its Application to the Pharmacokinetic Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jeong%20Woo%20Kang">Jeong Woo Kang</a>, <a href="https://publications.waset.org/abstracts/search?q=MiYoung%20Baek"> MiYoung Baek</a>, <a href="https://publications.waset.org/abstracts/search?q=Ki-Suk%20Kim"> Ki-Suk Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang-Jick%20Lee"> Kwang-Jick Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=ByungJae%20So"> ByungJae So</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: A fast, easy and sensitive detection method was developed and validated by liquid chromatography tandem mass spectrometry for the determination of marbofloxacin in pig plasma which was further applied to study the pharmacokinetics of marbofloxacin. Materials and Methods: The plasma sample (500 μL) was mixed with 1.5 ml of 0.1% formic acid in MeCN to precipitate plasma proteins. After shaking for 20 min, The mixture was centrifuged at 5,000 × g for 30 min. It was dried under a nitrogen flow at 50℃. 500 μL aliquot of the sample was injected into the LC-MS/MS system. Chromatographic analysis was carried out mobile phase gradient consisting 0.1% formic acid in D.W. (A) and 0.1% formic acid in MeCN (B) with C18 reverse phase column. Mass spectrometry was performed using the positive ion mode and the selected ion monitoring (MRM). Results and Conclusions: The method validation was performed in the sample matrix. Good linearities (R2>0.999) were observed and the quantified average recoveries of marbofloxacin were 87 - 92% at level of 10 ng g-1 -100 ng g-1. The percent of coefficient of variation (CV) for the described method was less than 10 % over the range of concentrations studied. The limits of detection (LOD) and quantification (LOQ) were 2 and 5 ng g-1, respectively. This method has also been applied successfully to pharmacokinetic analysis of marbofloxacin after intravenous (IV), intramuscular (IM) and oral administration (PO). The mean peak plasma concentration (Cmax) was 2,597 ng g-1at 0.25 h, 2,587 ng g-1at 0.44 h and 2,355 ng g-1at 1.58 h for IV, IM and PO, respectively. The area under the plasma concentration-time curve (AUC0–t) was 24.8, 29.0 and 25.2 h μg/mL for IV, IM and PO, respectively. The elimination half-life (T1/2) was 8.6, 13.1 and 9.5 for IV, IM and PO, respectively. Bioavailability (F) of the marbofloxacin in pig was 117 and 101 % for IM and PO, respectively. Based on these result, marbofloxacin does not have any obstacles as therapeutics to develop the oral formulations such as tablets and capsules. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=marbofloxacin" title="marbofloxacin">marbofloxacin</a>, <a href="https://publications.waset.org/abstracts/search?q=LC-MS%2FMS" title=" LC-MS/MS"> LC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacokinetics" title=" pharmacokinetics"> pharmacokinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=chromatographic" title=" chromatographic "> chromatographic </a> </p> <a href="https://publications.waset.org/abstracts/2814/determination-of-marbofloxacin-in-pig-plasma-using-lc-msms-and-its-application-to-the-pharmacokinetic-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2814.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">548</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3776</span> Fuel Oxidation Reactions: Pathways and Reactive Intermediates Characterization via Synchrotron Photoionization Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Giovanni%20Meloni">Giovanni Meloni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recent results are presented from experiments carried out at the Advanced Light Source (ALS) at the Chemical Dynamics Beamline of Lawrence Berkeley National Laboratory using multiplexed synchrotron photoionization mass spectrometry. The reaction mixture and a buffer gas (He) are introduced through individually calibrated mass flow controllers into a quartz slow flow reactor held at constant pressure and temperature. The gaseous mixture effuses through a 650 μm pinhole into a 1.5 mm skimmer, forming a molecular beam that enters a differentially pumped ionizing chamber. The molecular beam is orthogonally intersected by a tunable synchrotron radiation produced by the ALS in the 8-11 eV energy range. Resultant ions are accelerated, collimated, and focused into an orthogonal time-of-flight mass spectrometer. Reaction species are identified by their mass-to-charge ratios and photoionization (PI) spectra. Comparison of experimental PI spectra with literature and/or simulated curves is routinely done to assure the identity of a given species. With the aid of electronic structure calculations, potential energy surface scans are performed, and Franck-Condon spectral simulations are obtained. Examples of these experiments are discussed, ranging from new intermediates characterization to reaction mechanisms elucidation and biofuels oxidation pathways identification. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title="mass spectrometry">mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=reaction%20intermediates" title=" reaction intermediates"> reaction intermediates</a>, <a href="https://publications.waset.org/abstracts/search?q=synchrotron%20photoionization" title=" synchrotron photoionization"> synchrotron photoionization</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidation%20reactions" title=" oxidation reactions"> oxidation reactions</a> </p> <a href="https://publications.waset.org/abstracts/173937/fuel-oxidation-reactions-pathways-and-reactive-intermediates-characterization-via-synchrotron-photoionization-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/173937.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">73</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3775</span> A Step-by-Step Analytical Protocol For Detecting and Identifying Minor Differences In Like Materials and Polymers Using Pyrolysis -Gas Chromatography/Mass Spectrometry Technique</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Athena%20Nguyen">Athena Nguyen</a>, <a href="https://publications.waset.org/abstracts/search?q=Rojin%20Belganeh"> Rojin Belganeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Detecting and identifying differences in like polymer materials are key factors in failure and deformulation analysis, and reverse engineering. Pyrolysis-GC/MS is an easy solid sample introduction technique which expands the application areas of gas chromatography and mass spectrometry. The Micro furnace pyrolyzer is directly interfaced with the GC injector preventing any potential of cold spot, carryover, and cross contamination. In this presentation, the analysis of the differences in three polystyrene samples is demonstrated. Although the three samples look very similar by Evolve gas analysis (EGA) and Flash pyrolysis, there are indications of small levels of other materials. By performing Thermal desorption-GC/MS, the additive compounds between samples show the differences. EGA, flash pyrolysis, and thermal desorption analysis are the different modes of operations of the micro-furnace pyrolyzer enabling users to perform multiple analytical techniques. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gas%20chromatography%2FMass%20spectrometry" title="Gas chromatography/Mass spectrometry">Gas chromatography/Mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrolysis" title=" pyrolysis"> pyrolysis</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrolyzer" title=" pyrolyzer"> pyrolyzer</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20desorption-GC%2FMS" title=" thermal desorption-GC/MS"> thermal desorption-GC/MS</a> </p> <a href="https://publications.waset.org/abstracts/139716/a-step-by-step-analytical-protocol-for-detecting-and-identifying-minor-differences-in-like-materials-and-polymers-using-pyrolysis-gas-chromatographymass-spectrometry-technique" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139716.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">187</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3774</span> De-Novo Structural Elucidation from Mass/NMR Spectra</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ismael%20Zamora">Ismael Zamora</a>, <a href="https://publications.waset.org/abstracts/search?q=Elisabeth%20Ortega"> Elisabeth Ortega</a>, <a href="https://publications.waset.org/abstracts/search?q=Tatiana%20Radchenko"> Tatiana Radchenko</a>, <a href="https://publications.waset.org/abstracts/search?q=Guillem%20Plasencia"> Guillem Plasencia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The structure elucidation based on Mass Spectra (MS) data of unknown substances is an unresolved problem that affects many different fields of application. The recent overview of software available for structure elucidation of small molecules has shown the demand for efficient computational tool that will be able to perform structure elucidation of unknown small molecules and peptides. We developed an algorithm for De-Novo fragment analysis based on MS data that proposes a set of scored and ranked structures that are compatible with the MS and MSMS spectra. Several different algorithms were developed depending on the initial set of fragments and the structure building processes. Also, in all cases, several scores for the final molecule ranking were computed. They were validated with small and middle databases (DB) with the eleven test set compounds. Similar results were obtained from any of the databases that contained the fragments of the expected compound. We presented an algorithm. Or De-Novo fragment analysis based on only mass spectrometry (MS) data only that proposed a set of scored/ranked structures that was validated on different types of databases and showed good results as proof of concept. Moreover, the solutions proposed by Mass Spectrometry were submitted to the prediction of NMR spectra in order to elucidate which of the proposed structures was compatible with the NMR spectra collected. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=De%20Novo" title="De Novo">De Novo</a>, <a href="https://publications.waset.org/abstracts/search?q=structure%20elucidation" title=" structure elucidation"> structure elucidation</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=NMR" title=" NMR"> NMR</a> </p> <a href="https://publications.waset.org/abstracts/58568/de-novo-structural-elucidation-from-massnmr-spectra" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58568.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3773</span> Modelling and Optimization Analysis of Silicon/MgZnO-CBTSSe Tandem Solar Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vallisree%20Sivathanu">Vallisree Sivathanu</a>, <a href="https://publications.waset.org/abstracts/search?q=Kumaraswamidhas%20Lakshmi%20Annamalai"> Kumaraswamidhas Lakshmi Annamalai</a>, <a href="https://publications.waset.org/abstracts/search?q=Trupti%20Ranjan%20Lenka"> Trupti Ranjan Lenka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We report a tandem solar cell model with Silicon as the bottom cell absorber material and Cu₂BaSn(S, Se)₄(CBTSSe) as absorber material for the top cell. As a first step, the top and bottom cells were modelled and validated by comparison with the experiment. Once the individual cells are validated, then the tandem structure is modelled with Indium Tin Oxide(ITO) as conducting layer between the top and bottom cells. The tandem structure yielded better open circuit voltage and fill factor; however, the efficiency obtained is 7.01%. The top cell and the bottom cells are investigated with the help of electron-hole current density, photogeneration rate, and external quantum efficiency profiles. In order to minimize the various loss mechanisms in the tandem solar cell, the material parameters are optimized within experimentally achievable limits. Initially, the top cell optimization was carried out; then, the bottom cell is optimized for maximizing the light absorption, and upon minimizing the current and photon losses in the tandem structure, the maximum achievable efficiency is predicted to be 19.52%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CBTSSe" title="CBTSSe">CBTSSe</a>, <a href="https://publications.waset.org/abstracts/search?q=silicon" title=" silicon"> silicon</a>, <a href="https://publications.waset.org/abstracts/search?q=tandem" title=" tandem"> tandem</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title=" solar cell"> solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=device%20modeling" title=" device modeling"> device modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=current%20losses" title=" current losses"> current losses</a>, <a href="https://publications.waset.org/abstracts/search?q=photon%20losses" title=" photon losses"> photon losses</a> </p> <a href="https://publications.waset.org/abstracts/177529/modelling-and-optimization-analysis-of-siliconmgzno-cbtsse-tandem-solar-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177529.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">117</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3772</span> A Method for Quantifying Arsenolipids in Sea Water by HPLC-High Resolution Mass Spectrometry </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muslim%20Khan">Muslim Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Kenneth%20B.%20Jensen"> Kenneth B. Jensen</a>, <a href="https://publications.waset.org/abstracts/search?q=Kevin%20A.%20Francesconi"> Kevin A. Francesconi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Trace amounts (ca 1 µg/L, 13 nM) of arsenic are present in sea water mostly as the oxyanion arsenate. In contrast, arsenic is present in marine biota (animals and algae) at very high levels (up to100,000 µg/kg) a significant portion of which is present as lipid-soluble compounds collectively termed arsenolipids. The complex nature of sea water presents an analytical challenge to detect trace compounds and monitor their environmental path. We developed a simple method using liquid-liquid extraction combined with HPLC-High Resolution Mass Spectrometer capable of detecting trace of arsenolipids (99 % of the sample matrix while recovering > 80 % of the six target arsenolipids with limit of detection of 0.003 µg/L.) <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=arsenolipids" title="arsenolipids">arsenolipids</a>, <a href="https://publications.waset.org/abstracts/search?q=sea%20water" title=" sea water"> sea water</a>, <a href="https://publications.waset.org/abstracts/search?q=HPLC-high%20resolution%20mass%20spectrometry" title=" HPLC-high resolution mass spectrometry"> HPLC-high resolution mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/39793/a-method-for-quantifying-arsenolipids-in-sea-water-by-hplc-high-resolution-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39793.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">366</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3771</span> Comparative Proteomic Profiling of Planktonic and Biofilms from Staphylococcus aureus Using Tandem Mass Tag-Based Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arifur%20Rahman">Arifur Rahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Ardeshir%20Amirkhani"> Ardeshir Amirkhani</a>, <a href="https://publications.waset.org/abstracts/search?q=Honghua%20Hu"> Honghua Hu</a>, <a href="https://publications.waset.org/abstracts/search?q=Mark%20Molloy"> Mark Molloy</a>, <a href="https://publications.waset.org/abstracts/search?q=Karen%20Vickery"> Karen Vickery</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction and Objectives: Staphylococcus aureus and coagulase-negative staphylococci comprises approximately 65% of infections associated with medical devices and are well known for their biofilm formatting ability. Biofilm-related infections are extremely difficult to eradicate owing to their high tolerance to antibiotics and host immune defences. Currently, there is no efficient method for early biofilm detection. A better understanding to enable detection of biofilm specific proteins in vitro and in vivo can be achieved by studying planktonic and different growth phases of biofilms using a proteome analysis approach. Our goal was to construct a reference map of planktonic and biofilm associated proteins of S. aureus. Methods: S. aureus reference strain (ATCC 25923) was used to grow 24 hours planktonic, 3-day wet biofilm (3DWB), and 12-day wet biofilm (12DWB). Bacteria were grown in tryptic soy broth (TSB) liquid medium. Planktonic growth was used late logarithmic bacteria, and the Centres for Disease Control (CDC) biofilm reactor was used to grow 3 days, and 12-day hydrated biofilms, respectively. Samples were subjected to reduction, alkylation and digestion steps prior to Multiplex labelling using Tandem Mass Tag (TMT) 10-plex reagent (Thermo Fisher Scientific). The labelled samples were pooled and fractionated by high pH RP-HPLC which followed by loading of the fractions on a nanoflow UPLC system (Eksigent UPLC system, AB SCIEX). Mass spectrometry (MS) data were collected on an Orbitrap Elite (Thermo Fisher Scientific) Mass Spectrometer. Protein identification and relative quantitation of protein levels were performed using Proteome Discoverer (version 1.3, Thermo Fisher Scientific). After the extraction of protein ratios with Proteome Discoverer, additional processing, and statistical analysis was done using the TMTPrePro R package. Results and Discussion: The present study showed that a considerable proteomic difference exists among planktonic and biofilms from S. aureus. We identified 1636 total extracellular secreted proteins, of which 350 and 137 proteins of 3DWB and 12DWB showed significant abundance variation from planktonic preparation, respectively. Of these, simultaneous up-regulation in between 3DWB and 12DWB proteins such as extracellular matrix-binding protein ebh, enolase, transketolase, triosephosphate isomerase, chaperonin, peptidase, pyruvate kinase, hydrolase, aminotransferase, ribosomal protein, acetyl-CoA acetyltransferase, DNA gyrase subunit A, glycine glycyltransferase and others we found in this biofilm producer. On the contrary, simultaneous down-regulation in between 3DWB and 12DWB proteins such as alpha and delta-hemolysin, lipoteichoic acid synthase, enterotoxin I, serine protease, lipase, clumping factor B, regulatory protein Spx, phosphoglucomutase, and others also we found in this biofilm producer. In addition, we also identified a big percentage of hypothetical proteins including unique proteins. Therefore, a comprehensive knowledge of planktonic and biofilm associated proteins identified by S. aureus will provide a basis for future studies on the development of vaccines and diagnostic biomarkers. Conclusions: In this study, we constructed an initial reference map of planktonic and various growth phase of biofilm associated proteins which might be helpful to diagnose biofilm associated infections. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bacterial%20biofilms" title="bacterial biofilms">bacterial biofilms</a>, <a href="https://publications.waset.org/abstracts/search?q=CDC%20bioreactor" title=" CDC bioreactor"> CDC bioreactor</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20aureus" title=" S. aureus"> S. aureus</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=TMT" title=" TMT"> TMT</a> </p> <a href="https://publications.waset.org/abstracts/77519/comparative-proteomic-profiling-of-planktonic-and-biofilms-from-staphylococcus-aureus-using-tandem-mass-tag-based-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77519.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">171</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3770</span> Stability of Essential Oils in Pang-Rum by Gas Chromatography-Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Jarmkom">K. Jarmkom</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Eakwaropas"> P. Eakwaropas</a>, <a href="https://publications.waset.org/abstracts/search?q=W.%20Khobjai"> W. Khobjai</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Techaeoi"> S. Techaeoi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ancient Thai perfumed powder was used as a fragrance for clothing, food, and the body. Plant-based natural Thai perfume products are known as Pang-Rum. The objective of this study was to evaluate the stability of essential oils after six months of incubation. The chemical compositions were determined by gas chromatography-mass spectrometry (GC-MS), in terms of the qualitative composition of the isolated essential oil. The isolation of the essential oil of natural products by incubate sample for 5 min at 40 ºC is described. The volatile components were identified by percentage of total peak areas comparing their retention times of GC chromatograph with NIST mass spectral library. The results show no significant difference in the seven chromatograms of perfumed powder (Pang-Rum) both with binder and without binder. Further identification was done by GC-MS. Some components of Pang-Rum with/without binder were changed by temperature and time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=GC-MS%20analysis" title="GC-MS analysis">GC-MS analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=essential%20oils" title=" essential oils"> essential oils</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a>, <a href="https://publications.waset.org/abstracts/search?q=Pang-Rum" title=" Pang-Rum"> Pang-Rum</a> </p> <a href="https://publications.waset.org/abstracts/61580/stability-of-essential-oils-in-pang-rum-by-gas-chromatography-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61580.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">272</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3769</span> Chemical Fingerprinting of Complex Samples With the Aid of Parallel Outlet Flow Chromatography</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xavier%20A.%20Conlan">Xavier A. Conlan </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Speed of analysis is a significant limitation to current high-performance liquid chromatography/mass spectrometry (HPLC/MS) and ultra-high-pressure liquid chromatography (UHPLC)/MS systems both of which are used in many forensic investigations. The flow rate limitations of MS detection require a compromise in the chromatographic flow rate, which in turn reduces throughput, and when using modern columns, a reduction in separation efficiency. Commonly, this restriction is combated through the post-column splitting of flow prior to entry into the mass spectrometer. However, this results in a loss of sensitivity and a loss in efficiency due to the post-extra column dead volume. A new chromatographic column format known as 'parallel segmented flow' involves the splitting of eluent flow within the column outlet end fitting, and in this study we present its application in order to interrogate the provenience of methamphetamine samples with mass spectrometry detection. Using parallel segmented flow, column flow rates as high as 3 mL/min were employed in the analysis of amino acids without post-column splitting to the mass spectrometer. Furthermore, when parallel segmented flow chromatography columns were employed, the sensitivity was more than twice that of conventional systems with post-column splitting when the same volume of mobile phase was passed through the detector. These finding suggest that this type of column technology will particularly enhance the capabilities of modern LC/MS enabling both high-throughput and sensitive mass spectral detection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chromatography" title="chromatography">chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry%20methamphetamine" title=" mass spectrometry methamphetamine"> mass spectrometry methamphetamine</a>, <a href="https://publications.waset.org/abstracts/search?q=parallel%20segmented%20outlet%20flow%20column" title=" parallel segmented outlet flow column"> parallel segmented outlet flow column</a>, <a href="https://publications.waset.org/abstracts/search?q=forensic%20sciences" title=" forensic sciences"> forensic sciences</a> </p> <a href="https://publications.waset.org/abstracts/23798/chemical-fingerprinting-of-complex-samples-with-the-aid-of-parallel-outlet-flow-chromatography" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23798.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">491</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3768</span> Comparison of Physicochemical Properties of Catfish Myofibrillar and Sarcoplasmic Protein Hydrolysates and Characterization of Their Bioactive Peptides</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Leila%20Najafian">Leila Najafian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sarcoplasmic protein hydrolysates (SPHs) and myofibrillar protein hydrolysates (MPHs) from patin (Pangasius sutchi) were produced using two types of proteases: Papain and Alcalase. 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical scavenging activities and metal chelating activity assays for antioxidant activities were carried out on the SPHs and MPHs. The hydrolysates were isolated and purified by ultrafiltration, gel filtration and reverse phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography with tandem mass spectrometry detection (LC-MS/MS) was used in identifying peptide sequences. The results showed that when the DH of MPHs increased, the protein solubility increased, while the highest amount of the protein solubility of SPHs was after 60 min incubation. The effect of DH on antioxidant activities of SPHs and MPHs was investigated. Among the hydrolysates, papain-MPH and Alcalase-SPH, which had the highest antioxidant activities, were purified. The potent fractions obtained from RP-HPLC of sarcoplasmic (SI 3 fraction) and myofibrillar (MI 4 fraction) hydrolysates showed the highest DPPH radical scavenging activity. The FVNQPYLLYSVHMK peptide for MPH and the LVVDIPAALQHA peptide for SPH exhibited the highest antioxidant activity. The presence of hydrophobic and hydrophilic amino acids, namely leucine (L), valine (V), phenylalanine (F), histidine (H) and proline (P), in the peptide sequences of SPH and MPH are believed to contribute to high antioxidant activity. Hence, SPH and MPH from patin have the potential as a natural functional ingredient in food and pharmaceutical industry. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=patin%20%28Pangasius%20sutchi%29" title="patin (Pangasius sutchi)">patin (Pangasius sutchi)</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%20hydrolysates" title=" protein hydrolysates"> protein hydrolysates</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidative%20peptides" title=" antioxidative peptides"> antioxidative peptides</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/49761/comparison-of-physicochemical-properties-of-catfish-myofibrillar-and-sarcoplasmic-protein-hydrolysates-and-characterization-of-their-bioactive-peptides" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49761.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">260</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3767</span> Use of Fabric Phase Sorptive Extraction with Gas Chromatography-Mass Spectrometry for the Determination of Organochlorine Pesticides in Various Aqueous and Juice Samples</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ramandeep%20Kaur">Ramandeep Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashok%20Kumar%20Malik"> Ashok Kumar Malik</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fabric Phase Sorptive Extraction (FPSE) combined with Gas chromatography Mass Spectrometry (GCMS) has been developed for the determination of nineteen organochlorine pesticides in various aqueous samples. The method consolidates the features of sol-gel derived microextraction sorbents with rich surface chemistry of cellulose fabric substrate which could directly extract sample from complex sample matrices and incredibly improve the operation with decreased pretreatment time. Some vital parameters such as kind and volume of extraction solvent and extraction time were examinedand optimized. Calibration curves were obtained in the concentration range 0.5-500 ng/mL. Under the optimum conditions, the limits of detection (LODs) were in the range 0.033 ng/mL to 0.136 ng/mL. The relative standard deviations (RSDs) for extraction of 10 ng/mL 0f OCPs were less than 10%. The developed method has been applied for the quantification of these compounds in aqueous and fruit juice samples. The results obtained proved the present method to be rapid and feasible for the determination of organochlorine pesticides in aqueous samples. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fabric%20phase%20sorptive%20extraction" title="fabric phase sorptive extraction">fabric phase sorptive extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20chromatography-mass%20spectrometry" title=" gas chromatography-mass spectrometry"> gas chromatography-mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=organochlorine%20pesticides" title=" organochlorine pesticides"> organochlorine pesticides</a>, <a href="https://publications.waset.org/abstracts/search?q=sample%20pretreatment" title=" sample pretreatment"> sample pretreatment</a> </p> <a href="https://publications.waset.org/abstracts/80494/use-of-fabric-phase-sorptive-extraction-with-gas-chromatography-mass-spectrometry-for-the-determination-of-organochlorine-pesticides-in-various-aqueous-and-juice-samples" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80494.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">484</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3766</span> Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Godwin%20Dennison">Godwin Dennison</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20E.%20Boulind"> C. E. Boulind</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Gould"> O. Gould</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20de%20Lacy%20Costello"> B. de Lacy Costello</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Allison"> J. Allison</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20White"> P. White</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Ewings"> P. Ewings</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Wicaksono"> A. Wicaksono</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20J.%20Curtis"> N. J. Curtis</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Pullyblank"> A. Pullyblank</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Jayne"> D. Jayne</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20A.%20Covington"> J. A. Covington</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Ratcliffe"> N. Ratcliffe</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20K.%20Francis"> N. K. Francis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Colorectal symptoms are common but only infrequently represent serious pathology, including colorectal cancer (CRC). A large number of invasive tests are presently performed for reassurance. We investigated the feasibility of urinary volatile organic compound (VOC) testing as a potential triage tool in patients fast-tracked for assessment for possible CRC. Methods: A prospective, multi-centre, observational feasibility study was performed across three sites. Patients referred on NHS fast-track pathways for potential CRC provided a urine sample which underwent Gas Chromatography Mass Spectrometry (GC-MS), Field Asymmetric Ion Mobility Spectrometry (FAIMS) and Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) analysis. Patients underwent colonoscopy and/or CT colonography and were grouped as either CRC, adenomatous polyp(s), or controls to explore the diagnostic accuracy of VOC output data supported by an artificial neural network (ANN) model. Results: 558 patients participated with 23 (4.1%) CRC diagnosed. 59% of colonoscopies and 86% of CT colonographies showed no abnormalities. Urinary VOC testing was feasible, acceptable to patients, and applicable within the clinical fast track pathway. GC-MS showed the highest clinical utility for CRC and polyp detection vs. controls (sensitivity=0.878, specificity=0.882, AUROC=0.884). Conclusion: Urinary VOC testing and analysis are feasible within NHS fast-track CRC pathways. Clinically meaningful differences between patients with cancer, polyps, or no pathology were identified therefore suggesting VOC analysis may have future utility as a triage tool. Acknowledgment: Funding: NIHR Research for Patient Benefit grant (ref: PB-PG-0416-20022). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colorectal%20cancer" title="colorectal cancer">colorectal cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=volatile%20organic%20compound" title=" volatile organic compound"> volatile organic compound</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20chromatography%20mass%20spectrometry" title=" gas chromatography mass spectrometry"> gas chromatography mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=field%20asymmetric%20ion%20mobility%20spectrometry" title=" field asymmetric ion mobility spectrometry"> field asymmetric ion mobility spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=selected%20ion%20flow%20tube%20mass%20spectrometry" title=" selected ion flow tube mass spectrometry"> selected ion flow tube mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/152812/urinary-volatile-organic-compound-testing-in-fast-track-patients-with-suspected-colorectal-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152812.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">91</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3765</span> A Turn-on Fluorescent Sensor for Pb(II)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ece%20K%C3%B6k%20Yetimo%C4%9Flu">Ece Kök Yetimoğlu</a>, <a href="https://publications.waset.org/abstracts/search?q=Soner%20%C3%87ubuk"> Soner Çubuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Ne%C5%9Fe%20Ta%C5%9Fci"> Neşe Taşci</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Vezir%20Kahraman"> M. Vezir Kahraman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lead(II) is one of the most toxic environmental pollutants in the world, due to its high toxicity and non-biodegradability. Lead exposure causes severe risks to human health such as central brain damages, convulsions, kidney damages, and even death. To determine lead(II) in environmental or biological samples, scientists use atomic absorption spectrometry (AAS), inductively coupled plasma mass spectrometry (ICPMS), fluorescence spectrometry and electrochemical techniques. Among these systems the fluorescence spectrometry and fluorescent chemical sensors have attracted considerable attention because of their good selectivity and high sensitivity. The fluorescent polymers usually contain covalently bonded fluorophores. In this study imidazole based UV cured polymeric film was prepared and designed to act as a fluorescence chemo sensor for lead (II) analysis. The optimum conditions such as influence of pH value and time on the fluorescence intensity of the sensor have also been investigated. The sensor was highly sensitive with a detection limit as low as 1.87 × 10−8 mol L-1 and it was successful in the determination of Pb(II) in water samples. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fluorescence" title="fluorescence">fluorescence</a>, <a href="https://publications.waset.org/abstracts/search?q=lead%28II%29" title=" lead(II)"> lead(II)</a>, <a href="https://publications.waset.org/abstracts/search?q=photopolymerization" title=" photopolymerization"> photopolymerization</a>, <a href="https://publications.waset.org/abstracts/search?q=polymeric%20sensor" title=" polymeric sensor"> polymeric sensor</a> </p> <a href="https://publications.waset.org/abstracts/46887/a-turn-on-fluorescent-sensor-for-pbii" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46887.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">671</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3764</span> Deformulation and Comparative Analysis of Apparently Similar Polymers Using Multiple Modes of Pyrolysis-Gc/Ms</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Athena%20Nguyen">Athena Nguyen</a>, <a href="https://publications.waset.org/abstracts/search?q=Rojin%20Belganeh"> Rojin Belganeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Detecting and identifying differences in like polymer materials are key factors in deformulation, comparative analysis as well as reverse engineering. Pyrolysis-GC/MS is an easy solid sample introduction technique which expands the application areas of gas chromatography and mass spectrometry. The Micro-furnace pyrolyzer is directly interfaced with the GC injector preventing any potential of cold spot, carryover, and cross contamination. This presentation demonstrates the study of two similar polymers by performing different mode of operations in the same system: Evolve gas analysis (EGA), Flash pyrolysis, Thermal desorption analysis, and Heart-cutting analysis. Unknown polymer materials and their chemical compositions are identified. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gas%20chromatography%2Fmass%20spectrometry" title="gas chromatography/mass spectrometry">gas chromatography/mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrolysis" title=" pyrolysis"> pyrolysis</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrolyzer" title=" pyrolyzer"> pyrolyzer</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20desorption-GC%2FMS" title=" thermal desorption-GC/MS"> thermal desorption-GC/MS</a> </p> <a href="https://publications.waset.org/abstracts/139719/deformulation-and-comparative-analysis-of-apparently-similar-polymers-using-multiple-modes-of-pyrolysis-gcms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139719.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">264</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3763</span> Heroin and Opiates Metabolites Tracing by Gas-Chromatography Isotope Ratio Mass Spectrometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yao-Te%20Yen">Yao-Te Yen</a>, <a href="https://publications.waset.org/abstracts/search?q=Chao-Hsin%20Cheng"> Chao-Hsin Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Meng-Shun%20Huang"> Meng-Shun Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Shan-Zong%20Cyue"> Shan-Zong Cyue</a> </p> <p class="card-text"><strong>Abstract:</strong></p> 'Poppy-seed defense' has been a serious problem all over the world, that is because the opiates metabolites in urine are difficult to distinguish where they come from precisely. In this research, a powerful analytic method has been developed to trace the opiates metabolites in urine by Gas-Chromatography Isotope Ratio Mass Spectrometry (GC-IRMS). In order to eliminate the interference of synthesis to heroin or metabolism through human body, opiates metabolites in urine and sized heroin were hydrolyzed to morphine. Morphine is the key compound for tracing between opiates metabolites and seized heroin in this research. By matching δ13C and δ15N values through morphine, it is successful to distinguish the opiates metabolites coming from heroin or medicine. We tested seven heroin abuser’s metabolites and seized heroin in crime sites, the result showed that opiates metabolites coming from seized heroin, the variation of δ13C and δ15N for morphine are within 0.2 and 2.5‰, respectively. The variation of δ13C and δ15N for morphine are reasonable with the result of matrix match experiments. Above all, the uncertainty of 'Poppy-seed defense' can be solved easily by this analytic method, it provides the direct evidence for judge to make accurate conviction without hesitation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=poppy-seed%20defense" title="poppy-seed defense">poppy-seed defense</a>, <a href="https://publications.waset.org/abstracts/search?q=heroin" title=" heroin"> heroin</a>, <a href="https://publications.waset.org/abstracts/search?q=opiates%20metabolites" title=" opiates metabolites"> opiates metabolites</a>, <a href="https://publications.waset.org/abstracts/search?q=isotope%20ratio%20mass%20spectrometry" title=" isotope ratio mass spectrometry"> isotope ratio mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/74236/heroin-and-opiates-metabolites-tracing-by-gas-chromatography-isotope-ratio-mass-spectrometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/74236.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">239</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3762</span> Automatic Threshold Search for Heat Map Based Feature Selection: A Cancer Dataset Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Carlos%20Huertas">Carlos Huertas</a>, <a href="https://publications.waset.org/abstracts/search?q=Reyes%20Juarez-Ramirez"> Reyes Juarez-Ramirez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Public health is one of the most critical issues today; therefore, there is great interest to improve technologies in the area of diseases detection. With machine learning and feature selection, it has been possible to aid the diagnosis of several diseases such as cancer. In this work, we present an extension to the Heat Map Based Feature Selection algorithm, this modification allows automatic threshold parameter selection that helps to improve the generalization performance of high dimensional data such as mass spectrometry. We have performed a comparison analysis using multiple cancer datasets and compare against the well known Recursive Feature Elimination algorithm and our original proposal, the results show improved classification performance that is very competitive against current techniques. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomarker%20discovery" title="biomarker discovery">biomarker discovery</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=feature%20selection" title=" feature selection"> feature selection</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/46310/automatic-threshold-search-for-heat-map-based-feature-selection-a-cancer-dataset-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46310.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">338</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3761</span> Practical Evaluation of High-Efficiency Si-based Tandem Solar Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sue-Yi%20Chen">Sue-Yi Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Wei-Chun%20Hsu"> Wei-Chun Hsu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jon-Yiew%20Gan"> Jon-Yiew Gan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Si-based double-junction tandem solar cells have become a popular research topic because of the advantages of low manufacturing cost and high energy conversion efficiency. However, there is no set of calculations to select the appropriate top cell materials. Therefore, this paper will propose a simple but practical selection method. First of all, we calculate the S-Q limit and explain the reasons for developing tandem solar cells. Secondly, we calculate the theoretical energy conversion efficiency of the double-junction tandem solar cells while combining the commercial monocrystalline Si and materials' practical efficiency to consider the actual situation. Finally, we conservatively conclude that if considering 75% performance of the theoretical energy conversion efficiency of the top cell, the suitable bandgap energy range will fall between 1.38eV to 2.5eV. Besides, we also briefly describe some improvements of several proper materials, CZTS, CdSe, Cu2O, ZnTe, and CdS, hoping that future research can select and manufacture high-efficiency Si-based tandem solar cells based on this paper successfully. Most importantly, our calculation method is not limited to silicon solely. If other materials’ performances match or surpass silicon's ability in the future, researchers can also apply this set of deduction processes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=high-efficiency%20solar%20cells" title="high-efficiency solar cells">high-efficiency solar cells</a>, <a href="https://publications.waset.org/abstracts/search?q=material%20selection" title=" material selection"> material selection</a>, <a href="https://publications.waset.org/abstracts/search?q=Si-based%20double-junction%20solar%20cells" title=" Si-based double-junction solar cells"> Si-based double-junction solar cells</a>, <a href="https://publications.waset.org/abstracts/search?q=Tandem%20solar%20cells" title=" Tandem solar cells"> Tandem solar cells</a>, <a href="https://publications.waset.org/abstracts/search?q=photovoltaics." title=" photovoltaics."> photovoltaics.</a> </p> <a href="https://publications.waset.org/abstracts/147639/practical-evaluation-of-high-efficiency-si-based-tandem-solar-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/147639.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">116</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3760</span> Report on Yessotoxins and Pectenotoxins in Shellfish from the North Black Sea Coast of Bulgaria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zlatina%20Peteva">Zlatina Peteva</a>, <a href="https://publications.waset.org/abstracts/search?q=Stanislava%20Georgieva"> Stanislava Georgieva</a>, <a href="https://publications.waset.org/abstracts/search?q=Mona%20Stancheva"> Mona Stancheva</a>, <a href="https://publications.waset.org/abstracts/search?q=Lubomir%20Makedonsky"> Lubomir Makedonsky</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Yessotoxins (YTX) and pectenotoxins (PTX) are lipophilic polyether marine biotoxins that accumulate in shellfish and are regulated in the European Union. Aim of this study is investigation of the presence of YTXs and PTXs in Black Sea mussel (Mytilus galloprovincialis) on the North Black Sea cast of Bulgaria. YTX and PTX-2 have been identified in samples of the digestive glands of wild and cultivated samples. Mussel samples are harvested from two locations in important farming area on the Bulgarian North Black Sea coast in the period September 2016 – May 2017. Samples are analyzed by liquid chromatography tandem mass spectrometry (LC–MS/MS). In about 50 % of the samples analyzed the obtained concentration of YTX ranged from 10 – 5000 pg/g hepatopancreas and PTX-2 ranged from 300-7000 pg/g hepatopancreas. This is to our knowledge the first report of occurrence of lipophilic toxins in mussels from Bulgaria. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=yessotoxins" title="yessotoxins">yessotoxins</a>, <a href="https://publications.waset.org/abstracts/search?q=pectenotoxins" title=" pectenotoxins"> pectenotoxins</a>, <a href="https://publications.waset.org/abstracts/search?q=Black%20sea" title=" Black sea"> Black sea</a>, <a href="https://publications.waset.org/abstracts/search?q=mussels" title=" mussels"> mussels</a> </p> <a href="https://publications.waset.org/abstracts/76220/report-on-yessotoxins-and-pectenotoxins-in-shellfish-from-the-north-black-sea-coast-of-bulgaria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76220.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3759</span> Determination of Micronutrients in the Fruit of Cydonia oblonga Miller</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Madrakhimova%20Sakhiba">Madrakhimova Sakhiba</a>, <a href="https://publications.waset.org/abstracts/search?q=Matmurotov%20Bakhtishod"> Matmurotov Bakhtishod</a>, <a href="https://publications.waset.org/abstracts/search?q=Boltaboyava%20Zilola"> Boltaboyava Zilola</a>, <a href="https://publications.waset.org/abstracts/search?q=Matchanov%20Alimjan"> Matchanov Alimjan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Analyzing the chemical composition of locally consumed food products is one of the urgent problems in the health sector today. Taking this into account, it analyzed the microelement content of Cydonia oblonga Miller (COM) fruit growing in the Republic of Uzbekistan using the ISP MS inductively coupled mass spectrometry method. fruits brought to a constant mass in the analysis were mineralized in a mixture of nitric acid-HNO₃ and hydrogen peroxide-H₂O₂ in a ratio of 3:2. The mineralized extract was diluted to 50 milliliters with double-distilled water and analyzed. The results of the analysis showed that the fruit is rich in micronutrients necessary for the human body, especially potassium-K and phosphorus-P among macroelements, Strontium-Sr and barium-Ba from microelements are more than other microelements. It was observed that the amount of trace elements contained in COM fruit does not exceed the permissible standards. Therefore, it can be recommended to eat this fruit every day to prevent various diseases that occur in the human body. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cydonia%20oblonga%20miller" title="cydonia oblonga miller">cydonia oblonga miller</a>, <a href="https://publications.waset.org/abstracts/search?q=macroelement" title=" macroelement"> macroelement</a>, <a href="https://publications.waset.org/abstracts/search?q=microelement" title=" microelement"> microelement</a>, <a href="https://publications.waset.org/abstracts/search?q=inductively%20coupled%20mass%20spectrometry" title=" inductively coupled mass spectrometry"> inductively coupled mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrolysis" title=" hydrolysis"> hydrolysis</a>, <a href="https://publications.waset.org/abstracts/search?q=mineralization" title=" mineralization"> mineralization</a> </p> <a href="https://publications.waset.org/abstracts/181523/determination-of-micronutrients-in-the-fruit-of-cydonia-oblonga-miller" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/181523.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">71</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3758</span> Language and Culture Exchange: Tandem Language Learning for University Students</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hebe%20Wong">Hebe Wong</a>, <a href="https://publications.waset.org/abstracts/search?q=Luz%20Fernandez%20Calventos"> Luz Fernandez Calventos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tandem language learning, a language exchange process based on the principles of autonomy and reciprocity, provides opportunities for interlocutors to learn each other’s language by communicating online or face-to-face. While much attention has been paid to the process and outcomes of tandem learning via email, little has been discussed about the effectiveness of face-to-face tandem learning on language and culture exchange for university students. The LACTS (Language and Culture Tandem Scheme), an 8-week project, was set up to study students’ perceptions of conducting tandem learning to assist their language and culture exchange. Students of both post-graduate and undergraduate programmes (N=103) from a Hong Kong SAR university were put in groups of 4 to 6 according to their availability and language preferences and met for an hour a week. While sample task sheets on a range of topics were provided to assist the language exchange, all groups were encouraged to take charge of their meeting format and choose their own topics. At the end of the project, a 19-item questionnaire, which included both open-and closed-ended questions investigating students’ perceptions of reciprocal teaching and cultural exchange, was administered. Thirty-minute individual interviews were conducted to elicit students’ views and experiences in the LACTS activities. Quantitative and qualitative data analysis showed that most students agreed that the project had enhanced their cultural awareness and helped create an inclusive and participatory learning environment. Significant differences were found in students’ confidence in speaking their targeted language after joining the scheme. The interviews also provided rich data on the variety of formats and leadership patterns in student-led meetings, which could shed light on student autonomy and future tandem language learning projects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autonomy" title="autonomy">autonomy</a>, <a href="https://publications.waset.org/abstracts/search?q=reciprocity" title=" reciprocity"> reciprocity</a>, <a href="https://publications.waset.org/abstracts/search?q=tandem%20language%20learning" title=" tandem language learning"> tandem language learning</a>, <a href="https://publications.waset.org/abstracts/search?q=university%20students" title=" university students"> university students</a> </p> <a href="https://publications.waset.org/abstracts/182907/language-and-culture-exchange-tandem-language-learning-for-university-students" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/182907.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">58</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Tandem%20mass%20spectrometry&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Tandem%20mass%20spectrometry&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Tandem%20mass%20spectrometry&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Tandem%20mass%20spectrometry&page=5">5</a></li> <li class="page-item"><a class="page-link" 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