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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Interleukin</h1><div class="u-tcGrayDark">249 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Interleukin</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Interleukin">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Interleukin/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Interleukin/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Interleukin/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Interleukin">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11231053" data-work_id="11231053" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11231053/CD5_provides_viability_signals_to_B_cells_from_a_subset_of_B_CLL_patients_by_a_mechanism_that_involves_PKC">CD5 provides viability signals to B cells from a subset of B-CLL patients by a mechanism that involves PKC</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">B-chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease characterized by an accumulation of B lymphocytes expressing CD5. To date, the biological significance of this molecule in B-CLL B cells remains to be elucidated. In this... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11231053" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">B-chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease characterized by an accumulation of B lymphocytes expressing CD5. To date, the biological significance of this molecule in B-CLL B cells remains to be elucidated. In this study, we have analysed the functional consequences of the binding of an anti-CD5 antibody on B-CLL B cells. To this purpose, we have measured the percentage of viability of B-CLL B cells in the presence or in the absence of anti-CD5 antibodies and also examined some of the biochemical events downstream the CD5-signalling. We demonstrate that anti-CD5 induces phosphorylation of protein tyrosine kinases and protein kinase C (PKC), while no activation of Akt/PKB and MAPKs is detected. This signalling cascade results in viability in a group of patients in which we observe an increase of Mcl-1 levels, whereas the levels of bcl-2, bcl-xL and XIAP do not change. We also report that this pathway leads to IL-10 production, an immunoregulatory cytokine that might act as an autocrine growth factor for leukaemic B cells. Inhibition of PKC prevents the induction of Mcl-1 and IL-10, suggesting that the activation of PKC plays an important role in the CD5-mediated survival signals in B cells from a subset of B-CLL patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11231053" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4c75baed01e4deb7a49c9ded3c96622c" rel="nofollow" data-download="{"attachment_id":46805109,"asset_id":11231053,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46805109/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27139427" href="https://independent.academia.edu/PalomaPerezAciego">Paloma Perez-Aciego</a><script data-card-contents-for-user="27139427" type="text/json">{"id":27139427,"first_name":"Paloma","last_name":"Perez-Aciego","domain_name":"independent","page_name":"PalomaPerezAciego","display_name":"Paloma Perez-Aciego","profile_url":"https://independent.academia.edu/PalomaPerezAciego?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11231053 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11231053"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11231053, container: ".js-paper-rank-work_11231053", }); 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To date, the biological significance of this molecule in B-CLL B cells remains to be elucidated. In this study, we have analysed the functional consequences of the binding of an anti-CD5 antibody on B-CLL B cells. To this purpose, we have measured the percentage of viability of B-CLL B cells in the presence or in the absence of anti-CD5 antibodies and also examined some of the biochemical events downstream the CD5-signalling. We demonstrate that anti-CD5 induces phosphorylation of protein tyrosine kinases and protein kinase C (PKC), while no activation of Akt/PKB and MAPKs is detected. This signalling cascade results in viability in a group of patients in which we observe an increase of Mcl-1 levels, whereas the levels of bcl-2, bcl-xL and XIAP do not change. We also report that this pathway leads to IL-10 production, an immunoregulatory cytokine that might act as an autocrine growth factor for leukaemic B cells. Inhibition of PKC prevents the induction of Mcl-1 and IL-10, suggesting that the activation of PKC plays an important role in the CD5-mediated survival signals in B cells from a subset of B-CLL patients.","downloadable_attachments":[{"id":46805109,"asset_id":11231053,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27139427,"first_name":"Paloma","last_name":"Perez-Aciego","domain_name":"independent","page_name":"PalomaPerezAciego","display_name":"Paloma Perez-Aciego","profile_url":"https://independent.academia.edu/PalomaPerezAciego?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":14109,"name":"Leukemia","url":"https://www.academia.edu/Documents/in/Leukemia?f_ri=1924712","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=1924712","nofollow":false},{"id":38831,"name":"Signal 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dysfunction, shock, and death in emergency department patients with suspected sepsis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17765349" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6e0e89fc74c51c76c6a79a153ec951f8" rel="nofollow" data-download="{"attachment_id":39697225,"asset_id":17765349,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17765349"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="588" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="16664" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" 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u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This work reports the validation of a simple CZE method to be used in quality control of recombinant human glycosylated interleukin-7 (rhIL-7) batches produced in Chinese Hamster Ovary (CHO) cells. The separation buffer was a 25mM sodium... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73342921" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This work reports the validation of a simple CZE method to be used in quality control of recombinant human glycosylated interleukin-7 (rhIL-7) batches produced in Chinese Hamster Ovary (CHO) cells. The separation buffer was a 25mM sodium borate at pH 10 containing 12mM diaminobutane (DAB) used as a dynamic coating agent of the capillary. This method allowed the separation of seven peaks ranging from low to high sialylated glycoforms. An extensive study on conditioning methods of the capillary has been conducted to yield repeatable results. Excellent RSD of EOF mobility (less than 0.6%) was obtained when conditioning included capillary equilibration under virtual analyses and storage in 0.1M NaOH overnight. Method specificity has been demonstrated to be able to discriminate different rhIL-7 glycoforms produced in CHO from formulation matrix. Linearity was demonstrated between 0.5 and 4mg/mL. LOQ was 0.5mg/mL. Repeatability (RSD&lt;1.4 and 3.3% for t(m) and A%, respectively), intermed...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73342921" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="161612956" href="https://independent.academia.edu/AlahmadY">Yousef Alahmad</a><script data-card-contents-for-user="161612956" type="text/json">{"id":161612956,"first_name":"Yousef","last_name":"Alahmad","domain_name":"independent","page_name":"AlahmadY","display_name":"Yousef Alahmad","profile_url":"https://independent.academia.edu/AlahmadY?f_ri=1924712","photo":"https://0.academia-photos.com/161612956/45334190/65999339/s65_yousef.alahmad.jpg"}</script></span></span></li><li class="js-paper-rank-work_73342921 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73342921"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73342921, container: ".js-paper-rank-work_73342921", }); 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$(".js-view-count[data-work-id=73342921]").text(description); $(".js-view-count-work_73342921").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73342921").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73342921"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="524" href="https://www.academia.edu/Documents/in/Analytical_Chemistry">Analytical Chemistry</a>, <script data-card-contents-for-ri="524" type="text/json">{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="15375" href="https://www.academia.edu/Documents/in/Capillary_electrophoresis">Capillary electrophoresis</a>, <script data-card-contents-for-ri="15375" type="text/json">{"id":15375,"name":"Capillary electrophoresis","url":"https://www.academia.edu/Documents/in/Capillary_electrophoresis?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23890" href="https://www.academia.edu/Documents/in/Comparative_Study">Comparative Study</a><script data-card-contents-for-ri="23890" type="text/json">{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73342921]'), work: {"id":73342921,"title":"A validated capillary electrophoresis method to check for batch-to-batch consistency during recombinant human glycosylated interleukin-7 production campaigns","created_at":"2022-03-08T12:43:45.625-08:00","url":"https://www.academia.edu/73342921/A_validated_capillary_electrophoresis_method_to_check_for_batch_to_batch_consistency_during_recombinant_human_glycosylated_interleukin_7_production_campaigns?f_ri=1924712","dom_id":"work_73342921","summary":"This work reports the validation of a simple CZE method to be used in quality control of recombinant human glycosylated interleukin-7 (rhIL-7) batches produced in Chinese Hamster Ovary (CHO) cells. The separation buffer was a 25mM sodium borate at pH 10 containing 12mM diaminobutane (DAB) used as a dynamic coating agent of the capillary. This method allowed the separation of seven peaks ranging from low to high sialylated glycoforms. An extensive study on conditioning methods of the capillary has been conducted to yield repeatable results. Excellent RSD of EOF mobility (less than 0.6%) was obtained when conditioning included capillary equilibration under virtual analyses and storage in 0.1M NaOH overnight. Method specificity has been demonstrated to be able to discriminate different rhIL-7 glycoforms produced in CHO from formulation matrix. Linearity was demonstrated between 0.5 and 4mg/mL. LOQ was 0.5mg/mL. Repeatability (RSD\u0026lt;1.4 and 3.3% for t(m) and A%, respectively), intermed...","downloadable_attachments":[],"ordered_authors":[{"id":161612956,"first_name":"Yousef","last_name":"Alahmad","domain_name":"independent","page_name":"AlahmadY","display_name":"Yousef Alahmad","profile_url":"https://independent.academia.edu/AlahmadY?f_ri=1924712","photo":"https://0.academia-photos.com/161612956/45334190/65999339/s65_yousef.alahmad.jpg"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=1924712","nofollow":false},{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry?f_ri=1924712","nofollow":false},{"id":15375,"name":"Capillary electrophoresis","url":"https://www.academia.edu/Documents/in/Capillary_electrophoresis?f_ri=1924712","nofollow":false},{"id":23890,"name":"Comparative 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u-pv7x u-mb0x js-work-card work_63952242" data-work_id="63952242" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63952242/Presentation_of_receiver_operating_characteristics_ROC_plots">Presentation of receiver-operating characteristics (ROC) plots</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63952242" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0722d02dc7720500ff161386e99a1654" 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}); });</script></span><script>$(function() { $(".js-view-count-work_63952242").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63952242"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="41839" href="https://www.academia.edu/Documents/in/Clinical_Chemistry">Clinical Chemistry</a>, <script data-card-contents-for-ri="41839" type="text/json">{"id":41839,"name":"Clinical Chemistry","url":"https://www.academia.edu/Documents/in/Clinical_Chemistry?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="82978" href="https://www.academia.edu/Documents/in/Reactive_Oxygen_Species">Reactive Oxygen Species</a>, <script data-card-contents-for-ri="82978" type="text/json">{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="84243" href="https://www.academia.edu/Documents/in/Medical_Biotechnology">Medical Biotechnology</a><script data-card-contents-for-ri="84243" type="text/json">{"id":84243,"name":"Medical Biotechnology","url":"https://www.academia.edu/Documents/in/Medical_Biotechnology?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63952242]'), work: {"id":63952242,"title":"Presentation of receiver-operating characteristics (ROC) plots","created_at":"2021-12-13T01:25:51.246-08:00","url":"https://www.academia.edu/63952242/Presentation_of_receiver_operating_characteristics_ROC_plots?f_ri=1924712","dom_id":"work_63952242","summary":null,"downloadable_attachments":[{"id":76205316,"asset_id":63952242,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":204618906,"first_name":"Christophe","last_name":"Depuydt","domain_name":"independent","page_name":"ChristopheDepuydt","display_name":"Christophe Depuydt","profile_url":"https://independent.academia.edu/ChristopheDepuydt?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":41839,"name":"Clinical Chemistry","url":"https://www.academia.edu/Documents/in/Clinical_Chemistry?f_ri=1924712","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712","nofollow":false},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=1924712","nofollow":false},{"id":84243,"name":"Medical Biotechnology","url":"https://www.academia.edu/Documents/in/Medical_Biotechnology?f_ri=1924712","nofollow":false},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve?f_ri=1924712"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=1924712"},{"id":781610,"name":"Semen","url":"https://www.academia.edu/Documents/in/Semen?f_ri=1924712"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61246472" data-work_id="61246472" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61246472/Essential_involvement_of_interleukin_8_IL_8_in_acute_inflammation">Essential involvement of interleukin-8 (IL-8) in acute inflammation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neutrophil infiltration into inflammatory sites is one of the hallmarks of acute inflammation. Locally produced chemotactic factors are presumed to mediate the sequence of events leading to the infiltration at inflammatory sites.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61246472" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neutrophil infiltration into inflammatory sites is one of the hallmarks of acute inflammation. Locally produced chemotactic factors are presumed to mediate the sequence of events leading to the infiltration at inflammatory sites. Interleukin-8 (IL-8), a novel leukocyte chemotactic activating cytokine (chemokine), is produced by various types of cells upon stimulation with inflammatory stimuli and exerts a variety of functions on leukocytes, particularly, neutrophils in vitro. However, no definitive evidence has been presented on its role in recruiting and activating neutrophils in the lesions of various types of inflammatory reactions. We administered a highly specific neutralizing antibody against IL-8 in several types of acute inflammatory reactions, including lipopolysaccharide (LPS)-induced dermatitis, LPS/IL-1-induced arthritis, lung reperfusion injury, and acute immune complex-type glomerulonephritis. Anti-IL-8 treatment prevented neutrophil-dependent tissue damage as well as ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61246472" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c0400d64fdaa379fea9a96ea163e6b5c" rel="nofollow" data-download="{"attachment_id":74342930,"asset_id":61246472,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74342930/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42169623" href="https://independent.academia.edu/NaofumiMukaida">Naofumi Mukaida</a><script data-card-contents-for-user="42169623" type="text/json">{"id":42169623,"first_name":"Naofumi","last_name":"Mukaida","domain_name":"independent","page_name":"NaofumiMukaida","display_name":"Naofumi Mukaida","profile_url":"https://independent.academia.edu/NaofumiMukaida?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61246472 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61246472"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61246472, container: ".js-paper-rank-work_61246472", }); 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$(".js-view-count[data-work-id=61246472]").text(description); $(".js-view-count-work_61246472").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61246472").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61246472"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9334" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48183" href="https://www.academia.edu/Documents/in/Lipopolysaccharide">Lipopolysaccharide</a>, <script data-card-contents-for-ri="48183" type="text/json">{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="51789" href="https://www.academia.edu/Documents/in/Antibodies">Antibodies</a><script data-card-contents-for-ri="51789" type="text/json">{"id":51789,"name":"Antibodies","url":"https://www.academia.edu/Documents/in/Antibodies?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61246472]'), work: {"id":61246472,"title":"Essential involvement of interleukin-8 (IL-8) in acute inflammation","created_at":"2021-11-07T18:09:12.476-08:00","url":"https://www.academia.edu/61246472/Essential_involvement_of_interleukin_8_IL_8_in_acute_inflammation?f_ri=1924712","dom_id":"work_61246472","summary":"Neutrophil infiltration into inflammatory sites is one of the hallmarks of acute inflammation. Locally produced chemotactic factors are presumed to mediate the sequence of events leading to the infiltration at inflammatory sites. Interleukin-8 (IL-8), a novel leukocyte chemotactic activating cytokine (chemokine), is produced by various types of cells upon stimulation with inflammatory stimuli and exerts a variety of functions on leukocytes, particularly, neutrophils in vitro. However, no definitive evidence has been presented on its role in recruiting and activating neutrophils in the lesions of various types of inflammatory reactions. We administered a highly specific neutralizing antibody against IL-8 in several types of acute inflammatory reactions, including lipopolysaccharide (LPS)-induced dermatitis, LPS/IL-1-induced arthritis, lung reperfusion injury, and acute immune complex-type glomerulonephritis. Anti-IL-8 treatment prevented neutrophil-dependent tissue damage as well as ...","downloadable_attachments":[{"id":74342930,"asset_id":61246472,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42169623,"first_name":"Naofumi","last_name":"Mukaida","domain_name":"independent","page_name":"NaofumiMukaida","display_name":"Naofumi Mukaida","profile_url":"https://independent.academia.edu/NaofumiMukaida?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1924712","nofollow":false},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=1924712","nofollow":false},{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide?f_ri=1924712","nofollow":false},{"id":51789,"name":"Antibodies","url":"https://www.academia.edu/Documents/in/Antibodies?f_ri=1924712","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1924712"},{"id":115488,"name":"Lung Diseases","url":"https://www.academia.edu/Documents/in/Lung_Diseases?f_ri=1924712"},{"id":191096,"name":"Arthritis","url":"https://www.academia.edu/Documents/in/Arthritis?f_ri=1924712"},{"id":295260,"name":"Neutrophils","url":"https://www.academia.edu/Documents/in/Neutrophils?f_ri=1924712"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides?f_ri=1924712"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits?f_ri=1924712"},{"id":794984,"name":"Reperfusion injury","url":"https://www.academia.edu/Documents/in/Reperfusion_injury?f_ri=1924712"},{"id":861371,"name":"Dermatitis","url":"https://www.academia.edu/Documents/in/Dermatitis?f_ri=1924712"},{"id":1175837,"name":"Immune Complex","url":"https://www.academia.edu/Documents/in/Immune_Complex?f_ri=1924712"},{"id":1601249,"name":"Glomerulonephritis","url":"https://www.academia.edu/Documents/in/Glomerulonephritis?f_ri=1924712"},{"id":1703190,"name":"Neutralizing antibodies","url":"https://www.academia.edu/Documents/in/Neutralizing_antibodies?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48693190" data-work_id="48693190" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48693190/UVB_exposure_induced_systemic_modulation_of_Th1_and_Th2_mediated_immune_responses">UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48693190" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="20a1ae30b24e763102ec7835d07099ab" rel="nofollow" data-download="{"attachment_id":67174181,"asset_id":48693190,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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responses","created_at":"2021-05-05T05:14:27.434-07:00","url":"https://www.academia.edu/48693190/UVB_exposure_induced_systemic_modulation_of_Th1_and_Th2_mediated_immune_responses?f_ri=1924712","dom_id":"work_48693190","summary":null,"downloadable_attachments":[{"id":67174181,"asset_id":48693190,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35121385,"first_name":"Frank","last_name":"Gruijl","domain_name":"independent","page_name":"FrankGruijl","display_name":"Frank Gruijl","profile_url":"https://independent.academia.edu/FrankGruijl?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1924712","nofollow":false},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=1924712","nofollow":false},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen?f_ri=1924712","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=1924712","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1924712"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=1924712"},{"id":379038,"name":"Contact Dermatitis","url":"https://www.academia.edu/Documents/in/Contact_Dermatitis?f_ri=1924712"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma?f_ri=1924712"},{"id":2079216,"name":"Lymph nodes","url":"https://www.academia.edu/Documents/in/Lymph_nodes?f_ri=1924712"},{"id":3005391,"name":"Ultraviolet Rays","url":"https://www.academia.edu/Documents/in/Ultraviolet_Rays?f_ri=1924712"},{"id":3067128,"name":"reverse transcriptase polymerase chain reaction","url":"https://www.academia.edu/Documents/in/reverse_transcriptase_polymerase_chain_reaction?f_ri=1924712"},{"id":3508723,"name":"Ovalbumin ","url":"https://www.academia.edu/Documents/in/Ovalbumin?f_ri=1924712"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_47190645" data-work_id="47190645" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47190645/Immunogenicity_and_protective_efficacy_of_tuberculosis_subunit_vaccines_expressing_PPE44_Rv2770c_">Immunogenicity and protective efficacy of tuberculosis subunit vaccines expressing PPE44 (Rv2770c)</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47190645" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span 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class="clearfix u-pv7x u-mb0x js-work-card work_5332305" data-work_id="5332305" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5332305/A_monoclonal_antibody_that_appears_to_recognize_the_receptor_for_human_T_cell_growth_factor_partial_characterization_of_the_receptor">A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">T-cell growth factor (TCGF or interleukin-2) is an inducible glycoprotein hormone of molecular weight 15,000 (ref. 1) synthesized and secreted by T lymphocytes following activation with antigen or mitogen2,3. TCGF is required for... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5332305" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">T-cell growth factor (TCGF or interleukin-2) is an inducible glycoprotein hormone of molecular weight 15,000 (ref. 1) synthesized and secreted by T lymphocytes following activation with antigen or mitogen2,3. TCGF is required for proliferation and expansion of T cells following antigen encounter4,5 and to maintain them in long-term culture in vitro6-9. Full expression of the human immune response requires both the induction of TCGF synthesis and the formation of specific TCGF membrane receptors10,11. Monoclonal antibodies binding TCGF have been prepared12,13. In contrast, antibodies specific for the TCGF membrane receptor have not been identified, nor has the receptor been characterized. We have prepared a monoclonal antibody, termed anti-Tac14,15, which appears to bind to the human membrane receptor for TCGF. In support of this, we now demonstrate that anti-Tac suppresses TCGF induced proliferation of T cells and blocks binding of radiolabelled TCGF to cells from a cloned human continuous T-cell line. Also we have partially purified and characterized the putative TCGF receptor. This receptor is a glycoprotein with a molecular weight (Mr) of 47,000-53,000.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5332305" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="70374b1f86e5d2980cf9b1fbd32a4936" rel="nofollow" data-download="{"attachment_id":49338186,"asset_id":5332305,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49338186/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7373461" href="https://independent.academia.edu/joeldepper">joel depper</a><script data-card-contents-for-user="7373461" type="text/json">{"id":7373461,"first_name":"joel","last_name":"depper","domain_name":"independent","page_name":"joeldepper","display_name":"joel depper","profile_url":"https://independent.academia.edu/joeldepper?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_5332305 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5332305"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5332305, container: ".js-paper-rank-work_5332305", }); 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partial characterization of the receptor","created_at":"2013-12-05T10:45:37.056-08:00","url":"https://www.academia.edu/5332305/A_monoclonal_antibody_that_appears_to_recognize_the_receptor_for_human_T_cell_growth_factor_partial_characterization_of_the_receptor?f_ri=1924712","dom_id":"work_5332305","summary":"T-cell growth factor (TCGF or interleukin-2) is an inducible glycoprotein hormone of molecular weight 15,000 (ref. 1) synthesized and secreted by T lymphocytes following activation with antigen or mitogen2,3. TCGF is required for proliferation and expansion of T cells following antigen encounter4,5 and to maintain them in long-term culture in vitro6-9. Full expression of the human immune response requires both the induction of TCGF synthesis and the formation of specific TCGF membrane receptors10,11. Monoclonal antibodies binding TCGF have been prepared12,13. In contrast, antibodies specific for the TCGF membrane receptor have not been identified, nor has the receptor been characterized. We have prepared a monoclonal antibody, termed anti-Tac14,15, which appears to bind to the human membrane receptor for TCGF. In support of this, we now demonstrate that anti-Tac suppresses TCGF induced proliferation of T cells and blocks binding of radiolabelled TCGF to cells from a cloned human continuous T-cell line. Also we have partially purified and characterized the putative TCGF receptor. This receptor is a glycoprotein with a molecular weight (Mr) of 47,000-53,000.","downloadable_attachments":[{"id":49338186,"asset_id":5332305,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":7373461,"first_name":"joel","last_name":"depper","domain_name":"independent","page_name":"joeldepper","display_name":"joel depper","profile_url":"https://independent.academia.edu/joeldepper?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=1924712","nofollow":false},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=1924712","nofollow":false},{"id":33319,"name":"Nature","url":"https://www.academia.edu/Documents/in/Nature?f_ri=1924712","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712","nofollow":false},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies?f_ri=1924712"},{"id":193464,"name":"Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis","url":"https://www.academia.edu/Documents/in/Sodium_Dodecyl_Sulfate-Polyacrylamide_Gel_Electrophoresis?f_ri=1924712"},{"id":695018,"name":"Molecular weight","url":"https://www.academia.edu/Documents/in/Molecular_weight?f_ri=1924712"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28696699" data-work_id="28696699" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28696699/Depression_of_liver_metabolism_and_induction_of_cytokine_release_by_diphtheria_and_tetanus_toxoids_and_pertussis_vaccines_role_of_Bordetella_pertussis_cells_in_toxicity">Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A 24-h pretreatment of mice with diphtheria and tetanus toxoids and whole-cell pertussis vaccines depressed liver cytochrome P-450 and therefore prolonged hexobarbital-induced sleeping time in mice. The depression of liver drug metabolism... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_28696699" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A 24-h pretreatment of mice with diphtheria and tetanus toxoids and whole-cell pertussis vaccines depressed liver cytochrome P-450 and therefore prolonged hexobarbital-induced sleeping time in mice. The depression of liver drug metabolism by a cellular vaccine containing a mutated pertussis toxin was less marked than that induced by the wild-type vaccines, indicating that the mutated vaccine might have lower toxicity in this regard. The wild-type vaccines decreased microsomal P-450 levels by 50%, while the mutated whole-cell vaccine had a less marked effect (a decrease of 30%), paralleling the results obtained in sleeping time experiments. Furthermore, an acellular mutated vaccine did not affect liver drug metabolism, indicating a role of the whole bacterial cell in this side effect. All the cellular vaccines studied induced high serum interleukin-6 levels; on the other hand, the acellular mutated vaccine induced very low interleukin-6 levels, indicating that the whole bacterial cel...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28696699" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="71e50aa0e0b237abcf736170b4db586d" rel="nofollow" data-download="{"attachment_id":49090441,"asset_id":28696699,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49090441/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11933615" href="https://uic.academia.edu/GiamilaFantuzzi">Giamila Fantuzzi</a><script data-card-contents-for-user="11933615" type="text/json">{"id":11933615,"first_name":"Giamila","last_name":"Fantuzzi","domain_name":"uic","page_name":"GiamilaFantuzzi","display_name":"Giamila Fantuzzi","profile_url":"https://uic.academia.edu/GiamilaFantuzzi?f_ri=1924712","photo":"https://0.academia-photos.com/11933615/3429504/4033391/s65_giamila.fantuzzi.jpg"}</script></span></span></li><li class="js-paper-rank-work_28696699 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="28696699"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 28696699, container: ".js-paper-rank-work_28696699", }); 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$(".js-view-count[data-work-id=28696699]").text(description); $(".js-view-count-work_28696699").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_28696699").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="28696699"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9111" href="https://www.academia.edu/Documents/in/Cytokines">Cytokines</a>, <script data-card-contents-for-ri="9111" type="text/json">{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48758" href="https://www.academia.edu/Documents/in/Infection_and_immunity">Infection and immunity</a>, <script data-card-contents-for-ri="48758" type="text/json">{"id":48758,"name":"Infection and immunity","url":"https://www.academia.edu/Documents/in/Infection_and_immunity?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71437" href="https://www.academia.edu/Documents/in/Liver">Liver</a><script data-card-contents-for-ri="71437" type="text/json">{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28696699]'), work: {"id":28696699,"title":"Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity","created_at":"2016-09-24T12:23:53.476-07:00","url":"https://www.academia.edu/28696699/Depression_of_liver_metabolism_and_induction_of_cytokine_release_by_diphtheria_and_tetanus_toxoids_and_pertussis_vaccines_role_of_Bordetella_pertussis_cells_in_toxicity?f_ri=1924712","dom_id":"work_28696699","summary":"A 24-h pretreatment of mice with diphtheria and tetanus toxoids and whole-cell pertussis vaccines depressed liver cytochrome P-450 and therefore prolonged hexobarbital-induced sleeping time in mice. The depression of liver drug metabolism by a cellular vaccine containing a mutated pertussis toxin was less marked than that induced by the wild-type vaccines, indicating that the mutated vaccine might have lower toxicity in this regard. The wild-type vaccines decreased microsomal P-450 levels by 50%, while the mutated whole-cell vaccine had a less marked effect (a decrease of 30%), paralleling the results obtained in sleeping time experiments. Furthermore, an acellular mutated vaccine did not affect liver drug metabolism, indicating a role of the whole bacterial cell in this side effect. All the cellular vaccines studied induced high serum interleukin-6 levels; on the other hand, the acellular mutated vaccine induced very low interleukin-6 levels, indicating that the whole bacterial cel...","downloadable_attachments":[{"id":49090441,"asset_id":28696699,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":11933615,"first_name":"Giamila","last_name":"Fantuzzi","domain_name":"uic","page_name":"GiamilaFantuzzi","display_name":"Giamila Fantuzzi","profile_url":"https://uic.academia.edu/GiamilaFantuzzi?f_ri=1924712","photo":"https://0.academia-photos.com/11933615/3429504/4033391/s65_giamila.fantuzzi.jpg"}],"research_interests":[{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=1924712","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=1924712","nofollow":false},{"id":48758,"name":"Infection and immunity","url":"https://www.academia.edu/Documents/in/Infection_and_immunity?f_ri=1924712","nofollow":false},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver?f_ri=1924712","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=1924712"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1924712"},{"id":109739,"name":"Infection","url":"https://www.academia.edu/Documents/in/Infection?f_ri=1924712"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=1924712"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha?f_ri=1924712"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine?f_ri=1924712"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect?f_ri=1924712"},{"id":1250233,"name":"Tetanus Toxoid","url":"https://www.academia.edu/Documents/in/Tetanus_Toxoid?f_ri=1924712"},{"id":1714726,"name":"Bordetella Pertussis","url":"https://www.academia.edu/Documents/in/Bordetella_Pertussis?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28681345" data-work_id="28681345" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28681345/Relationship_between_the_Soluble_F11_Receptor_and_Markers_of_Inflammation_in_Hemodialysis_Patients">Relationship between the Soluble F11 Receptor and Markers of Inflammation in Hemodialysis Patients</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList 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href="https://www.academia.edu/Documents/in/Nonparametric_Statistics">Nonparametric Statistics</a>, <script data-card-contents-for-ri="3243" type="text/json">{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9111" href="https://www.academia.edu/Documents/in/Cytokines">Cytokines</a>, <script data-card-contents-for-ri="9111" type="text/json">{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="28850" href="https://www.academia.edu/Documents/in/Linear_models">Linear models</a>, <script data-card-contents-for-ri="28850" type="text/json">{"id":28850,"name":"Linear models","url":"https://www.academia.edu/Documents/in/Linear_models?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28681345]'), work: {"id":28681345,"title":"Relationship between the Soluble F11 Receptor and Markers of Inflammation in Hemodialysis 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Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26991125 coauthored" data-work_id="26991125" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26991125/Decreased_serum_hepcidin_and_improved_functional_iron_status_6_months_after_restrictive_bariatric_surgery">Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11136243/Inflammation_obesity_stress_and_coronary_heart_disease_is_interleukin_6_the_link">Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11136243" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f31c4f48e1fba1b3996d653912355cfa" rel="nofollow" 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type="text/json">{"id":8015,"name":"Atherosclerosis","url":"https://www.academia.edu/Documents/in/Atherosclerosis?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9334" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11136243]'), work: {"id":11136243,"title":"Inflammation, obesity, stress and coronary heart disease: is 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data-work_id="25793450" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25793450/Aloe_emodin_affects_the_levels_of_cytokines_and_functions_of_leukocytes_from_Sprague_Dawley_rats">Aloe-emodin affects the levels of cytokines and functions of leukocytes from Sprague-Dawley rats</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Aloe-emodin has shown anti-neoplastic activity against some human cancer cell lines. This study aimed to explore the effects of aloe-emodin on the phagocytosis of macrophages, the activity of natural killer (NK) cells and the expression... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25793450" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Aloe-emodin has shown anti-neoplastic activity against some human cancer cell lines. This study aimed to explore the effects of aloe-emodin on the phagocytosis of macrophages, the activity of natural killer (NK) cells and the expression of cytokines in leukocytes from Sprague-Dawley rats. Leukocytes were collected, placed into culture plates and the functions of macrophages and NK cells and the percentage of viable cells were determined by flow cytometric analysis. Incubation of leukocytes with various concentrations of aloe-emodin caused a dose-dependent decrease of viable cells, a decrease of phagocytosis by macrophages, and a decrease of the activity of NK cells. Evaluation of cytokines in leukocytes by ELISA indicated that aloe-emodin increased the levels of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. The results were also confirmed by PCR assay for the mRNA expression of the examined cytokines.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25793450" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fae2298a0369b6ea6f20ba838fdbcc4f" rel="nofollow" data-download="{"attachment_id":46156680,"asset_id":25793450,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46156680/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49506591" href="https://independent.academia.edu/SsuChingChen">Ssu-Ching Chen</a><script data-card-contents-for-user="49506591" type="text/json">{"id":49506591,"first_name":"Ssu-Ching","last_name":"Chen","domain_name":"independent","page_name":"SsuChingChen","display_name":"Ssu-Ching Chen","profile_url":"https://independent.academia.edu/SsuChingChen?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25793450 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25793450"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25793450, container: ".js-paper-rank-work_25793450", }); 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This study aimed to explore the effects of aloe-emodin on the phagocytosis of macrophages, the activity of natural killer (NK) cells and the expression of cytokines in leukocytes from Sprague-Dawley rats. Leukocytes were collected, placed into culture plates and the functions of macrophages and NK cells and the percentage of viable cells were determined by flow cytometric analysis. Incubation of leukocytes with various concentrations of aloe-emodin caused a dose-dependent decrease of viable cells, a decrease of phagocytosis by macrophages, and a decrease of the activity of NK cells. Evaluation of cytokines in leukocytes by ELISA indicated that aloe-emodin increased the levels of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. 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href="https://www.academia.edu/Documents/in/Toll_like_receptor_signaling">Toll like receptor signaling</a>, <script data-card-contents-for-ri="47265" type="text/json">{"id":47265,"name":"Toll like receptor signaling","url":"https://www.academia.edu/Documents/in/Toll_like_receptor_signaling?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="59366" href="https://www.academia.edu/Documents/in/Inflammatory_Bowel_Disease">Inflammatory Bowel Disease</a>, <script data-card-contents-for-ri="59366" type="text/json">{"id":59366,"name":"Inflammatory Bowel Disease","url":"https://www.academia.edu/Documents/in/Inflammatory_Bowel_Disease?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" 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type="text/json">{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23003585]'), work: {"id":23003585,"title":"Association of asthma with a functional promoter polymorphism in the IL16 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Toxin","url":"https://www.academia.edu/Documents/in/Diphtheria_Toxin?f_ri=1924712"},{"id":2028055,"name":"Interferon Alpha","url":"https://www.academia.edu/Documents/in/Interferon_Alpha?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_72050055" data-work_id="72050055" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72050055/Human_Lactoferrin_and_Peptides_Derived_from_a_Surface_Exposed_Helical_Region_Reduce_Experimental_Escherichia_coli_Urinary_Tract_Infection_in_Mice">Human Lactoferrin and Peptides Derived from a Surface-Exposed Helical Region Reduce Experimental Escherichia coli Urinary Tract Infection in Mice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Lactoferrin (LF) is a multifunctional immunoregulatory protein that has been associated with host defense at mucosal surfaces through its antibacterial properties. The antibacterial and anti-inflammatory properties of LF were further... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72050055" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Lactoferrin (LF) is a multifunctional immunoregulatory protein that has been associated with host defense at mucosal surfaces through its antibacterial properties. The antibacterial and anti-inflammatory properties of LF were further explored with an animal model of experimental urinary tract infection. Bovine LF (bLF), human LF (hLF), and synthetic peptide sequences based on the antibacterial region of hLF (amino acid residues 16 to 40 [HLD1] and 18 to 40 [HLD2]) were given orally to female mice 30 min after the instillation of 10 8 Escherichia coli bacteria into the urinary bladder. The control groups received phosphate-buffered saline or water. C3H/Tif mice were treated with hLF or bLF, and C3H/HeN mice were treated with bLF only. The numbers of bacteria in the kidneys and bladder of C3H/Tif and C3H/HeN mice were significantly reduced 24 h later by the LF treatments compared to the findings for the control group. The hLF-treated group showed the strongest reduction compared with ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72050055" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c714706205e30715e4cabad8aeada36c" rel="nofollow" data-download="{"attachment_id":81137976,"asset_id":72050055,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81137976/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34246514" href="https://independent.academia.edu/LilianaH%C3%A5versen">Liliana Håversen</a><script data-card-contents-for-user="34246514" type="text/json">{"id":34246514,"first_name":"Liliana","last_name":"Håversen","domain_name":"independent","page_name":"LilianaHåversen","display_name":"Liliana Håversen","profile_url":"https://independent.academia.edu/LilianaH%C3%A5versen?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_72050055 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72050055"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72050055, container: ".js-paper-rank-work_72050055", }); 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The antibacterial and anti-inflammatory properties of LF were further explored with an animal model of experimental urinary tract infection. Bovine LF (bLF), human LF (hLF), and synthetic peptide sequences based on the antibacterial region of hLF (amino acid residues 16 to 40 [HLD1] and 18 to 40 [HLD2]) were given orally to female mice 30 min after the instillation of 10 8 Escherichia coli bacteria into the urinary bladder. The control groups received phosphate-buffered saline or water. C3H/Tif mice were treated with hLF or bLF, and C3H/HeN mice were treated with bLF only. The numbers of bacteria in the kidneys and bladder of C3H/Tif and C3H/HeN mice were significantly reduced 24 h later by the LF treatments compared to the findings for the control group. The hLF-treated group showed the strongest reduction compared with ...","downloadable_attachments":[{"id":81137976,"asset_id":72050055,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34246514,"first_name":"Liliana","last_name":"Håversen","domain_name":"independent","page_name":"LilianaHåversen","display_name":"Liliana Håversen","profile_url":"https://independent.academia.edu/LilianaH%C3%A5versen?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=1924712","nofollow":false},{"id":48758,"name":"Infection and immunity","url":"https://www.academia.edu/Documents/in/Infection_and_immunity?f_ri=1924712","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=1924712","nofollow":false},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney?f_ri=1924712"},{"id":83128,"name":"Escherichia coli","url":"https://www.academia.edu/Documents/in/Escherichia_coli?f_ri=1924712"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=1924712"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=1924712"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1924712"},{"id":151951,"name":"Animal Model","url":"https://www.academia.edu/Documents/in/Animal_Model?f_ri=1924712"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle?f_ri=1924712"},{"id":585573,"name":"Amino Acid Profile","url":"https://www.academia.edu/Documents/in/Amino_Acid_Profile?f_ri=1924712"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=1924712"},{"id":1109980,"name":"Bacterial Adhesion","url":"https://www.academia.edu/Documents/in/Bacterial_Adhesion?f_ri=1924712"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=1924712"},{"id":1684568,"name":"Escherichia Coli Infections","url":"https://www.academia.edu/Documents/in/Escherichia_Coli_Infections?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"},{"id":2192856,"name":"Host Defense","url":"https://www.academia.edu/Documents/in/Host_Defense?f_ri=1924712"},{"id":2636453,"name":"Lactoferrin","url":"https://www.academia.edu/Documents/in/Lactoferrin?f_ri=1924712"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70417849" data-work_id="70417849" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70417849/Cytokine_Gene_Expression_in_B_Cell_Chronic_Lymphocytic_Leukemia_Evidence_of_Constitutive_Interleukin_8_IL_8_mRNA_Expression_and_Secretion_of_Biologically_Active_IL_8_Protein">Cytokine Gene Expression in B-Cell Chronic Lymphocytic Leukemia: Evidence of Constitutive Interleukin-8 (IL-8) mRNA Expression and Secretion of Biologically Active IL-8 Protein</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To extend our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70417849" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To extend our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a reversetranscriptase polymerase chain reaction method. 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fracture","url":"https://www.academia.edu/Documents/in/articular_fracture?f_ri=1924712"},{"id":4073093,"name":"Inflammation Mediators","url":"https://www.academia.edu/Documents/in/Inflammation_Mediators?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_68916446" data-work_id="68916446" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/68916446/Blockade_of_CD127_Exerts_a_Dichotomous_Clinical_Effect_in_Marmoset_Experimental_Autoimmune_Encephalomyelitis">Blockade of CD127 Exerts a Dichotomous Clinical Effect in Marmoset Experimental Autoimmune Encephalomyelitis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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Elias","profile_url":"https://independent.academia.edu/JackaElias?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=1924712","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=1924712","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=1924712","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=1924712","nofollow":false},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases?f_ri=1924712"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=1924712"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=1924712"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1924712"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical?f_ri=1924712"},{"id":371516,"name":"Eosinophils","url":"https://www.academia.edu/Documents/in/Eosinophils?f_ri=1924712"},{"id":1144154,"name":"Clinical Investigation","url":"https://www.academia.edu/Documents/in/Clinical_Investigation?f_ri=1924712"},{"id":1180711,"name":"Eosinophilia","url":"https://www.academia.edu/Documents/in/Eosinophilia?f_ri=1924712"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation?f_ri=1924712"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=1924712"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=1924712"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_65035698" data-work_id="65035698" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/65035698/Regular_and_moderate_exercise_before_experimental_sepsis_reduces_the_risk_of_lung_and_distal_organ_injury">Regular and moderate exercise before experimental sepsis reduces the risk of lung and distal organ injury</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Physical activity modulates inflammation and immune response in both normal and pathologic conditions. We investigated whether regular and moderate exercise before the induction of experimental sepsis reduces the risk of lung and distal... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_65035698" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Physical activity modulates inflammation and immune response in both normal and pathologic conditions. We investigated whether regular and moderate exercise before the induction of experimental sepsis reduces the risk of lung and distal organ injury and survival. One hundred twenty-four BALB/c mice were randomly assigned to two groups: sedentary (S) and trained (T). Animals in T group ran on a motorized treadmill, at moderate intensity, 5% grade, 30 min/day, 3 times a week for 8 wk. Cardiac adaptation to exercise was evaluated using echocardiography. Systolic volume and left ventricular mass were increased in T compared with S group. Both T and S groups were further randomized either to sepsis induced by cecal ligation and puncture surgery (CLP) or sham operation (control). After 24 h, lung mechanics and histology, the degree of cell apoptosis in lung, heart, kidney, liver, and small intestine villi, and interleukin (IL)-6, KC (IL-8 murine functional homolog), IL-1β, IL-10, and numb...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/65035698" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5e9b23eded1d77dcef82da879c9d78e3" rel="nofollow" data-download="{"attachment_id":76796253,"asset_id":65035698,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76796253/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40789040" href="https://independent.academia.edu/NazarethRocha">Nazareth Rocha</a><script data-card-contents-for-user="40789040" type="text/json">{"id":40789040,"first_name":"Nazareth","last_name":"Rocha","domain_name":"independent","page_name":"NazarethRocha","display_name":"Nazareth Rocha","profile_url":"https://independent.academia.edu/NazarethRocha?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_65035698 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="65035698"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 65035698, container: ".js-paper-rank-work_65035698", }); 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We investigated whether regular and moderate exercise before the induction of experimental sepsis reduces the risk of lung and distal organ injury and survival. One hundred twenty-four BALB/c mice were randomly assigned to two groups: sedentary (S) and trained (T). Animals in T group ran on a motorized treadmill, at moderate intensity, 5% grade, 30 min/day, 3 times a week for 8 wk. Cardiac adaptation to exercise was evaluated using echocardiography. Systolic volume and left ventricular mass were increased in T compared with S group. Both T and S groups were further randomized either to sepsis induced by cecal ligation and puncture surgery (CLP) or sham operation (control). After 24 h, lung mechanics and histology, the degree of cell apoptosis in lung, heart, kidney, liver, and small intestine villi, and interleukin (IL)-6, KC (IL-8 murine functional homolog), IL-1β, IL-10, and numb...","downloadable_attachments":[{"id":76796253,"asset_id":65035698,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40789040,"first_name":"Nazareth","last_name":"Rocha","domain_name":"independent","page_name":"NazarethRocha","display_name":"Nazareth Rocha","profile_url":"https://independent.academia.edu/NazarethRocha?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy?f_ri=1924712","nofollow":false},{"id":14079,"name":"Scanning Transmission Electron 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Memory","url":"https://www.academia.edu/Documents/in/Human_Memory?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6599" href="https://www.academia.edu/Documents/in/Flow_Cytometry">Flow Cytometry</a>, <script data-card-contents-for-ri="6599" type="text/json">{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9531" href="https://www.academia.edu/Documents/in/Vitamin_D">Vitamin D</a><script data-card-contents-for-ri="9531" type="text/json">{"id":9531,"name":"Vitamin D","url":"https://www.academia.edu/Documents/in/Vitamin_D?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=59417020]'), work: {"id":59417020,"title":"1α,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells","created_at":"2021-10-21T20:25:20.917-07:00","url":"https://www.academia.edu/59417020/1%CE%B1_25_Dihydroxyvitamin_D3_and_all_trans_retinoic_acid_synergistically_inhibit_the_differentiation_and_expansion_of_Th17_cells?f_ri=1924712","dom_id":"work_59417020","summary":null,"downloadable_attachments":[{"id":73351056,"asset_id":59417020,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32620401,"first_name":"Yoichiro","last_name":"Iwakura","domain_name":"u-tokyo","page_name":"YoichiroIwakura","display_name":"Yoichiro Iwakura","profile_url":"https://u-tokyo.academia.edu/YoichiroIwakura?f_ri=1924712","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1924712","nofollow":false},{"id":3303,"name":"Human Memory","url":"https://www.academia.edu/Documents/in/Human_Memory?f_ri=1924712","nofollow":false},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry?f_ri=1924712","nofollow":false},{"id":9531,"name":"Vitamin D","url":"https://www.academia.edu/Documents/in/Vitamin_D?f_ri=1924712","nofollow":false},{"id":9532,"name":"Vitamins","url":"https://www.academia.edu/Documents/in/Vitamins?f_ri=1924712"},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=1924712"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=1924712"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=1924712"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1924712"},{"id":225472,"name":"Inflammatory disease","url":"https://www.academia.edu/Documents/in/Inflammatory_disease?f_ri=1924712"},{"id":379038,"name":"Contact 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itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="48908225" href="https://independent.academia.edu/UteKoch">Ute Koch</a><script data-card-contents-for-user="48908225" type="text/json">{"id":48908225,"first_name":"Ute","last_name":"Koch","domain_name":"independent","page_name":"UteKoch","display_name":"Ute Koch","profile_url":"https://independent.academia.edu/UteKoch?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_57080810 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="57080810"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 57080810, container: ".js-paper-rank-work_57080810", }); });</script></li><li class="js-percentile-work_57080810 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span 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href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4987" href="https://www.academia.edu/Documents/in/Kinetics">Kinetics</a>, <script data-card-contents-for-ri="4987" type="text/json">{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="19295" href="https://www.academia.edu/Documents/in/Cryopreservation">Cryopreservation</a>, <script data-card-contents-for-ri="19295" type="text/json">{"id":19295,"name":"Cryopreservation","url":"https://www.academia.edu/Documents/in/Cryopreservation?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=43131344]'), work: {"id":43131344,"title":"Stability of Interleukin 6, Soluble Interleukin 6 Receptor, Interleukin 10 and CC16 in Human 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type="text/json">{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4086" href="https://www.academia.edu/Documents/in/Traditional_Medicine">Traditional Medicine</a>, <script data-card-contents-for-ri="4086" type="text/json">{"id":4086,"name":"Traditional Medicine","url":"https://www.academia.edu/Documents/in/Traditional_Medicine?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5541" href="https://www.academia.edu/Documents/in/Plant_Biology">Plant Biology</a><script data-card-contents-for-ri="5541" type="text/json">{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=1924712","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: 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concentrations (FeNO) status all together among patients with allergy in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13876583" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Information on sCD200 (OX-2), 25-Hydroxyvitamin-D(25(OH)D), homocysteine (hcy), eosinophil cationic peptid (ECP), d-dimer (DD), CXCL8, fractional exhale nitric oxide concentrations (FeNO) status all together among patients with allergy in mediterranean region in comparison of climatic conditions have not been well established yet. Blood samples were taken on May and June during the highest air pollination. Hence, this study was undertaken to compare these serum biomolecules’ levels in allergic patients and matched controls, to evaluate disease characteristics. The study participants (n=129) included 25 healthy individuals (controls) and 104 allergic patients. Consecutive patients with allergic disease (Group II,III,IV,V) above the age of 18 years, managed. In the control group there was a significant positive correlation between ECP and BMI. Positive correlations between ECP, IgE and OX-2 were detected in group IV. For group V patients, positive correlations between age and IgE and ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13876583" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5c22068477683647da1558e76a581ad4" rel="nofollow" data-download="{"attachment_id":39136789,"asset_id":13876583,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39136789/download_file?st=MTczMjM5NDg1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32955270" href="https://independent.academia.edu/OnurSeda">Seda Onur</a><script data-card-contents-for-user="32955270" type="text/json">{"id":32955270,"first_name":"Seda","last_name":"Onur","domain_name":"independent","page_name":"OnurSeda","display_name":"Seda Onur","profile_url":"https://independent.academia.edu/OnurSeda?f_ri=1924712","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13876583 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13876583"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13876583, container: ".js-paper-rank-work_13876583", }); 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type="text/json">{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5541" href="https://www.academia.edu/Documents/in/Plant_Biology">Plant Biology</a>, <script data-card-contents-for-ri="5541" type="text/json">{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a>, <script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=1924712","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="44842" href="https://www.academia.edu/Documents/in/Phytomedicine">Phytomedicine</a><script 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The role of major histocompatibility complex class I antigens in tumorigenesis: future applications in cancer therapy. Auteur(s) / Author(s). NAPOLITANO L. (1) ; VOGEL J. ; JAY G. ; Affiliation(s) du ou des auteurs / Author(s)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20924401" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">... The role of major histocompatibility complex class I antigens in tumorigenesis: future applications in cancer therapy. Auteur(s) / Author(s). NAPOLITANO L. (1) ; VOGEL J. ; JAY G. ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). ... 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