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The spontaneously hypertensive rat (SHR) is the most common animal model of hypertension, which is characterized by secondary ventricular dilation and" /> <meta name="twitter:image" content="https://0.academia-photos.com/227149112/84101202/72729964/s200_miriam.gonz_lez_g_mez.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/96216091/Altered_Expression_of_AQP1_and_AQP4_in_Brain_Barriers_and_Cerebrospinal_Fluid_May_Affect_Cerebral_Water_Balance_during_Chronic_Hypertension" /> <meta property="og:title" content="Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Hypertension is the leading cause of cardiovascular affection and premature death worldwide. The spontaneously hypertensive rat (SHR) is the most common animal model of hypertension, which is characterized by secondary ventricular dilation and" /> <meta property="article:author" content="https://independent.academia.edu/MiriamGonz%C3%A1lezG%C3%B3mez" /> <meta name="description" content="Hypertension is the leading cause of cardiovascular affection and premature death worldwide. The spontaneously hypertensive rat (SHR) is the most common animal model of hypertension, which is characterized by secondary ventricular dilation and" /> <title>(PDF) Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension | Miriam González Gómez - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/96216091/Altered_Expression_of_AQP1_and_AQP4_in_Brain_Barriers_and_Cerebrospinal_Fluid_May_Affect_Cerebral_Water_Balance_during_Chronic_Hypertension" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732402176000); window.Aedu.timeDifference = new Date().getTime() - 1732402176000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Hypertension is the leading cause of cardiovascular affection and premature death worldwide. The spontaneously hypertensive rat (SHR) is the most common animal model of hypertension, which is characterized by secondary ventricular dilation and hydrocephalus. Aquaporin (AQP) 1 and 4 are the main water channels responsible for the brain’s water balance. The present study focuses on defining the expression of AQPs through the time course of the development of spontaneous chronic hypertension. We performed immunofluorescence and ELISA to examine brain AQPs from 10 SHR, and 10 Wistar–Kyoto (WKY) rats studied at 6 and 12 months old. There was a significant decrease in AQP1 in the choroid plexus of the SHR-12-months group compared with the age-matched control (p \u0026amp;amp;lt; 0.05). In the ependyma, AQP4 was significantly decreased only in the SHR-12-months group compared with the control or SHR-6-months groups (p \u0026amp;amp;lt; 0.05). Per contra, AQP4 increased in astrocytes end-feet of 6 months and 12 mont...","author":[{"@context":"https://schema.org","@type":"Person","name":"Miriam González Gómez"}],"contributor":[],"dateCreated":"2023-02-03","dateModified":"2023-02-03","datePublished":null,"headline":"Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension","inLanguage":"en","keywords":["Endocrinology","Genetics","Medicine","Cerebrospinal Fluid","Internal Medicine","Choroid Plexus","Molecular sciences"],"locationCreated":null,"publication":"International Journal of Molecular Sciences","publisher":{"@context":"https://schema.org","@type":"Organization","name":"MDPI AG"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/96216091/Altered_Expression_of_AQP1_and_AQP4_in_Brain_Barriers_and_Cerebrospinal_Fluid_May_Affect_Cerebral_Water_Balance_during_Chronic_Hypertension","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" 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The spontaneously hypertensive rat (SHR) is the most common animal model of hypertension, which is characterized by secondary ventricular dilation and hydrocephalus. Aquaporin (AQP) 1 and 4 are the main water channels responsible for the brain’s water balance. The present study focuses on defining the expression of AQPs through the time course of the development of spontaneous chronic hypertension. We performed immunofluorescence and ELISA to examine brain AQPs from 10 SHR, and 10 Wistar–Kyoto (WKY) rats studied at 6 and 12 months old. There was a significant decrease in AQP1 in the choroid plexus of the SHR-12-months group compared with the age-matched control (p \u0026lt; 0.05). In the ependyma, AQP4 was significantly decreased only in the SHR-12-months group compared with the control or SHR-6-months groups (p \u0026lt; 0.05). Per contra, AQP4 increased in astrocytes end-feet of 6 months and 12 mont...","publisher":"MDPI AG","publication_name":"International Journal of Molecular Sciences"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [227149112]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":98176135,"attachmentType":"pdf"}"><img alt="First page of “Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/98176135/mini_magick20230203-1-19msjyc.png?1675413223" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="227149112" href="https://independent.academia.edu/MiriamGonz%C3%A1lezG%C3%B3mez"><img alt="Profile image of Miriam González Gómez" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/227149112/84101202/72729964/s65_miriam.gonz_lez_g_mez.jpeg" />Miriam González Gómez</a></div><p class="ds-work-card--detail ds2-5-body-sm">International Journal of Molecular Sciences</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Hypertension is the leading cause of cardiovascular affection and premature death worldwide. The spontaneously hypertensive rat (SHR) is the most common animal model of hypertension, which is characterized by secondary ventricular dilation and hydrocephalus. Aquaporin (AQP) 1 and 4 are the main water channels responsible for the brain’s water balance. The present study focuses on defining the expression of AQPs through the time course of the development of spontaneous chronic hypertension. We performed immunofluorescence and ELISA to examine brain AQPs from 10 SHR, and 10 Wistar–Kyoto (WKY) rats studied at 6 and 12 months old. There was a significant decrease in AQP1 in the choroid plexus of the SHR-12-months group compared with the age-matched control (p &lt; 0.05). In the ependyma, AQP4 was significantly decreased only in the SHR-12-months group compared with the control or SHR-6-months groups (p &lt; 0.05). Per contra, AQP4 increased in astrocytes end-feet of 6 months and 12 mont...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":98176135,"attachmentType":"pdf","workUrl":"https://www.academia.edu/96216091/Altered_Expression_of_AQP1_and_AQP4_in_Brain_Barriers_and_Cerebrospinal_Fluid_May_Affect_Cerebral_Water_Balance_during_Chronic_Hypertension"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":98176135,"attachmentType":"pdf","workUrl":"https://www.academia.edu/96216091/Altered_Expression_of_AQP1_and_AQP4_in_Brain_Barriers_and_Cerebrospinal_Fluid_May_Affect_Cerebral_Water_Balance_during_Chronic_Hypertension"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download 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data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55580512/Altered_cellular_localization_of_aquaporin_1_in_experimental_hydrocephalus_in_mice_and_reduced_ventriculomegaly_in_aquaporin_1_deficiency">Altered cellular localization of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="204141174" href="https://independent.academia.edu/MarkoNykanen">Marko Nykanen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular and Cellular Neuroscience, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Altered cellular localization of aquaporin-1 in experimental 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data-collection-position="6" data-entity-id="93352851" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93352851/Aquaporin_4_expression_is_not_elevated_in_mild_hydrocephalus">Aquaporin-4 expression is not elevated in mild hydrocephalus</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="250607508" href="https://independent.academia.edu/ErcanBal2">Ercan Bal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Neurochirurgica, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Aquaporin-4 expression is not elevated in mild hydrocephalus","attachmentId":96113776,"attachmentType":"pdf","work_url":"https://www.academia.edu/93352851/Aquaporin_4_expression_is_not_elevated_in_mild_hydrocephalus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/93352851/Aquaporin_4_expression_is_not_elevated_in_mild_hydrocephalus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="48230354" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48230354/Altered_expression_of_Aquaporin_2_in_one_kidney_one_clip_hypertension">Altered expression of Aquaporin-2 in one-kidney, one-clip hypertension</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31557320" href="https://independent.academia.edu/MarceloVatta">Marcelo Vatta</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Life sciences, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">The aim of the present study was to evaluate the regulation of Aquaporin-2 (AQP2) water channel in the kidney of one-kidney, one-clip rats (Goldblatt-1 model). In addition, some mechanisms that underlie the role of AQP2 in the Goldblatt-1 model were evaluated. Sprague-Dawley rats were divided in three groups: control two-kidney, no clip (C, 2 K-NC); nephrectomized one-kidney, no clip (N, 1 K-NC) and Goldblatt one-kidney, one-clip (G, 1 K-1C). AQP2 expression (by westernblot, real time PCR, immunohistochemistry and immunofluorescence), vasopressin V2 receptor expression (by real time PCR), cAMP concentration, NFkB and TonEBP (cytosol to nucleus ratio) were evaluated in the renal medulla. AQP2 expression, V2 receptor expression and cAMP concentration were decreased in the renal medulla of 1 K-1C rats, NFkB translocation was favoured towards the nucleus suggesting its activation while TonEBP translocation was not altered in this model of hypertension. In this model of hypertension the ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Altered expression of Aquaporin-2 in one-kidney, one-clip hypertension","attachmentId":66951167,"attachmentType":"pdf","work_url":"https://www.academia.edu/48230354/Altered_expression_of_Aquaporin_2_in_one_kidney_one_clip_hypertension","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/48230354/Altered_expression_of_Aquaporin_2_in_one_kidney_one_clip_hypertension"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="100562506" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/100562506/Cerebral_Microcirculation_Perivascular_Unit_and_Glymphatic_System_Role_of_Aquaporin_4_as_the_Gatekeeper_for_Water_Homeostasis">Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="135463868" href="https://independent.academia.edu/JoachimOertel">Joachim Oertel</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Neurology, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">In the past, water homeostasis of the brain was understood as a certain quantitative equilibrium of water content between intravascular, interstitial, and intracellular spaces governed mostly by hydrostatic effects i.e., strictly by physical laws. The recent achievements in molecular bioscience have led to substantial changes in this regard. Some new concepts elaborate the idea that all compartments involved in cerebral fluid homeostasis create a functional continuum with an active and precise regulation of fluid exchange between them rather than only serving as separate fluid receptacles with mere passive diffusion mechanisms, based on hydrostatic pressure. According to these concepts, aquaporin-4 (AQP4) plays the central role in cerebral fluid homeostasis, acting as a water channel protein. The AQP4 not only enables water permeability through the blood-brain barrier but also regulates water exchange between perivascular spaces and the rest of the glymphatic system, described as pa...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis","attachmentId":101351251,"attachmentType":"pdf","work_url":"https://www.academia.edu/100562506/Cerebral_Microcirculation_Perivascular_Unit_and_Glymphatic_System_Role_of_Aquaporin_4_as_the_Gatekeeper_for_Water_Homeostasis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/100562506/Cerebral_Microcirculation_Perivascular_Unit_and_Glymphatic_System_Role_of_Aquaporin_4_as_the_Gatekeeper_for_Water_Homeostasis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="87509867" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/87509867/Comparison_of_cardiovascular_aquaporin_1_changes_during_water_restriction_between_25_and_50_day_old_rats">Comparison of cardiovascular aquaporin-1 changes during water restriction between 25- and 50-day-old rats</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8343209" href="https://independent.academia.edu/MelinaChamorro">Melina Chamorro</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Nutrition, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison of cardiovascular aquaporin-1 changes during water restriction between 25- and 50-day-old rats","attachmentId":91697609,"attachmentType":"pdf","work_url":"https://www.academia.edu/87509867/Comparison_of_cardiovascular_aquaporin_1_changes_during_water_restriction_between_25_and_50_day_old_rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/87509867/Comparison_of_cardiovascular_aquaporin_1_changes_during_water_restriction_between_25_and_50_day_old_rats"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":98176135,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":98176135,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_98176135" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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ds2-5-body-link" data-author-id="25331553" href="https://independent.academia.edu/LilyLin8">Lily Lin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Neuroscience, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Correspondence of AQP4 expression and hypoxic-ischaemic brain oedema monitored by magnetic resonance imaging in the immature and juvenile rat","attachmentId":47434653,"attachmentType":"pdf","work_url":"https://www.academia.edu/10331841/Correspondence_of_AQP4_expression_and_hypoxic_ischaemic_brain_oedema_monitored_by_magnetic_resonance_imaging_in_the_immature_and_juvenile_rat","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/10331841/Correspondence_of_AQP4_expression_and_hypoxic_ischaemic_brain_oedema_monitored_by_magnetic_resonance_imaging_in_the_immature_and_juvenile_rat"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="13383387" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13383387/Aquaporin_2_water_channels_in_spontaneously_hypertensive_rats">Aquaporin-2 water channels in spontaneously hypertensive rats</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36080295" 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