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class="fl-page-content" itemprop="mainContentOfPage" role="main"> <div class="fl-content-full container"> <div class="row"> <div class="fl-content col-md-12"> <article class="fl-post post-23796 page type-page status-publish hentry" id="fl-post-23796" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-23796 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="23796"><div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-clhvrjx57dbp fl-row-default-height fl-row-align-center" data-node="clhvrjx57dbp"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-fc5wg6vpjdel" data-node="fc5wg6vpjdel"> <div class="fl-col fl-node-xnf6ztr82kes fl-col-bg-photo" data-node="xnf6ztr82kes"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-5c17vwp2gdfs" data-node="5c17vwp2gdfs"> <div class="fl-module-content fl-node-content"> <h1 class="fl-heading"> <span class="fl-heading-text">Pre-Conference Seminar Day</span> </h1> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-bu5vc0jemrns" data-node="bu5vc0jemrns"> <div class="fl-col fl-node-sh140direzpt fl-col-bg-color" data-node="sh140direzpt"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-xt7ofb8zdv1j" data-node="xt7ofb8zdv1j"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">Monday 3rd March, 2025</span> </h2> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-htagkqr9iljn" data-node="htagkqr9iljn"> <div class="fl-col fl-node-vkasyn3qfw4r fl-col-bg-color" data-node="vkasyn3qfw4r"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-dvk167ueo820" data-node="dvk167ueo820"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:30 am </span> Check In, Morning Coffee & Light Refreshments </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-k7s4lhjoczid" data-node="k7s4lhjoczid"> <div class="fl-col fl-node-gq45z2njd0kw fl-col-bg-color fl-col-has-cols" data-node="gq45z2njd0kw"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-tabs fl-node-vo1itkx7ufer" data-node="vo1itkx7ufer"> <div class="fl-module-content fl-node-content"> <div class="fl-tabs fl-tabs-vertical fl-clearfix"> <div class="fl-tabs-labels fl-clearfix" role="tablist"> <a href="#" class="fl-tabs-label fl-tab-active" id="fl-tabs-vo1itkx7ufer-label-0" data-index="0" aria-selected="true" aria-controls="fl-tabs-vo1itkx7ufer-panel-0" aria-expanded="true" role="tab" tabindex="0"> <span style="color: #666699; font-size: 16px;" id="IntrotoADCs"><strong>Introduction to ADCs</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-vo1itkx7ufer-label-1" data-index="1" aria-selected="false" aria-controls="fl-tabs-vo1itkx7ufer-panel-1" aria-expanded="false" role="tab" tabindex="0"> <span style="color: #ac7194; font-size: 16px;" id="NovelTargeting"><strong>3rd Novel Conjugates Day</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-vo1itkx7ufer-label-2" data-index="2" aria-selected="false" aria-controls="fl-tabs-vo1itkx7ufer-panel-2" aria-expanded="false" role="tab" tabindex="0"> <span style="color: #2b2a87; font-size: 16px;" id="Toxicity"><strong>2nd Toxicity Day</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-vo1itkx7ufer-label-3" data-index="3" aria-selected="false" aria-controls="fl-tabs-vo1itkx7ufer-panel-3" aria-expanded="false" role="tab" tabindex="0"> <span style="color: #e31e26; font-size: 16px;" id="PatientSelection"><strong>3rd ADCs in Combination Day</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-vo1itkx7ufer-label-4" data-index="4" aria-selected="false" aria-controls="fl-tabs-vo1itkx7ufer-panel-4" aria-expanded="false" role="tab" tabindex="0"> <span style="color: #990582; font-size: 16px;" id="Bioanalytical"><strong>1st Regulatory CMC Day</strong></span> </a> </div> <div class="fl-tabs-panels fl-clearfix"> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label fl-tab-active" data-index="0" tabindex="0"> <span><span style="color: #666699; font-size: 16px;" id="IntrotoADCs"><strong>Introduction to ADCs</strong></span></span> <i class="fas"></i> </div> <div class="fl-tabs-panel-content fl-clearfix fl-tab-active" id="fl-tabs-vo1itkx7ufer-panel-0" data-index="0" aria-labelledby="fl-tabs-vo1itkx7ufer-label-0" role="tabpanel" aria-live="polite"> <p id="IntrotoADCs" style="text-align: center;"><span style="color: #666699; font-size: 16px;"><strong>Introduction to ADCs</strong></span></p> <p style="text-align: center;"><em><span style="font-size: 16px;"> </span><span style="font-size: 16px;"><strong>John Lambert</strong>, Independent Consultant & Honorary Professor, </span><span style="font-size: 16px;"><strong>Queens University Belfast<br /> </strong></span></em></p> <p style="text-align: center;"><em><span style="font-size: 16px;"><strong> David Bramhill, </strong>President & Founder, <strong>Bramhill Biological Consulting</strong></span></em></p> <p style="text-align: center;"><strong>Are you new to the ADC field? If so, join our ADC 101 day to get your ADC knowledge up to scratch ahead of the scientific program days.</strong></p> <p style="text-align: left;">As more companies enter the ever-growing antibody-drug conjugate field, this seminar day will provide you with the critical knowledge gained over years of research and failed clinical trials that culminated in the presently approved ADCs and booming innovation in the field.</p> <p>Led by long-standing experts in the field, join this one-stop-shop of ADC learning to <strong>establish a core understanding of the essential elements in ADC discovery and early development</strong>.</p> <p style="text-align: center;"><span style="color: #a91970; font-size: 16px;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/" data-feathr-click-track="true" data-feathr-link-aids="5dfbace0aab76b48e7dec78e"><u>Download the Full Event Guide for full details</u></a></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #666699;">09.30 am</span> The morning session will cover:<br /> </strong></span></p> <ul> <li>Gaining familiarity with the fundamental early learnings that inform ADC design</li> <li>Learning about the key insights that allowed early investigators to overcome the initial challenges that hindered early ADC programmes</li> <li>Evaluating payload choices for ADCs</li> <li>Reviewing linker design chemistry and what it can bring</li> <li>Understanding the impact of conjugation site selection on ADCs</li> </ul> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong><span style="color: #666699;">12.30 pm</span><span style="color: #000000;"> Lunch & Networking</span></strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #666699;">1.30 pm</span> </strong></span>The afternoon session will cover:</p> <ul> <li>Gaining an understanding of the biological aspects of ADCs</li> <li>Selecting the most appropriate ADC target</li> <li>Choosing an optimum antibody format</li> <li>Analyzing the choices and trade-offs in utilizing the chemistry ADC toolbox</li> <li>Assessing key factors in the evaluation of efficacy information from in vivo preclinical models</li> </ul> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #666699;">3.00 pm</span> End of Introduction to ADCs Day</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="1" tabindex="0"> <span><span style="color: #ac7194; font-size: 16px;" id="NovelTargeting"><strong>3rd Novel Conjugates Day</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-vo1itkx7ufer-panel-1" data-index="1" aria-hidden="true" aria-labelledby="fl-tabs-vo1itkx7ufer-label-1" role="tabpanel" aria-live="polite"> <p id="NovelTargeting" style="text-align: center;"><span style="color: #ac7194; font-size: 16px;"><strong>3rd Novel Conjugates Day</strong></span></p> <p style="text-align: center;"><span style="font-size: 16px;"><em><strong>Chair: </strong><strong>Kevin Hamblett</strong>, Senior Director, ADC</em><br /> <em>Biology, <strong>Pfizer</strong></em></span></p> <p style="text-align: center;">ADC design innovation is booming with conjugates comprising non-traditional payloads and targeting moieties beyond antibodies. This not only expands the mechanisms of action and multi-target capability but also opens the door to applications beyond oncology. Join this seminar day to discover non-cytotoxic payloads across DACs and AOCs, bispecific ADC design and rationale, dual payload and high DAR ADCs, and bioconjugate applications in neurological diseases</p> <p style="text-align: center;"><span style="color: #a91970; font-size: 16px;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/" data-feathr-click-track="true" data-feathr-link-aids="5dfbace0aab76b48e7dec78e">Download the Full Event Guide for full details</a></span></p> <hr /> <p style="text-align: center;"><span style="color: #ac7194;"><strong>Assessing the New Frontier of ADC Payloads: How Do They Compare to the Tried & Tested Classics?</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">09.30 am</span> Diving Deeper into the Next Wave of ADCs</strong></span></p> <p>• Breaking down the novel drug conjugate landscape<br /> • Exploring emerging drug conjugate modalities<br /> and targets<br /> • Understanding the trial landscape of novel drug conjugates</p> <p><span style="font-size: 16px; color: #ac7194;"><strong>Yu-Shin Hsu</strong>, Research Analyst,<strong> Beacon by Hanson Wade</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">10.00 am</span> Targeted PROTAC Delivery: Principles of Crafting PROTAC-ADCs & Self-Assembling PROxAb Shuttles</strong></span></p> <p>• Summarising the current technological status of Degrader-ADCs, emphasising the challenges in their generation<br /> • Introducing the PROxAb Shuttle technology, which has the potential to expedite Degrader-ADC discovery<br /> • Presenting data showcasing the practical application of the PROxAb Shuttle <em>in vivo</em></p> <p><span style="color: #ac7194; font-size: 16px;"><strong>Marcel Rieker</strong>, Team Leader, PROxAb Shuttle,<strong> Merck KGaA</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">10.30 am</span> Exploring Delivery of BET Protein Degrader to Pancreatic Cancer & Microenvironment via CEACAM6-Targeted Degrader-Antibody Conjugate</strong></span></p> <p>• Discovering a novel payload effective on PDAC, BET protein degrader<br /> • Exploring a novel degrader-antibody conjugate (DAC) targeting CEACAM6<br /> • Showcasing anti-cancer efficacy and microenvironment modulation in PDAC models</p> <p><span style="font-size: 16px; color: #ac7194;"><strong>Shuntaro Tsukamoto</strong>, Scientist, <strong>Eisai</strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>11.00 am Morning Break & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="color: #ac7194;"><strong>Investigating Applications of ADCs & Conjugated Therapies in Indications Beyond Oncology</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">11.30 am</span> Bioconjugates in Neuroscience: Developing & Delivering Antibody-Oligonucleotide Conjugates Using BrainshuttleTM Technology</strong></span></p> <p>• Leveraging transferrin brain shuttle technology to deliver antibody oligonucleotide conjugates to the brain<br /> • Applying learnings from ADC conjugation and linker knowledge to inform bioconjugate design and biophysical properties<br /> • Outlining opportunities and challenges of applying antibody oligonucleotide conjugates in neuroscience</p> <p><span style="color: #ac7194; font-size: 16px;"><strong>Kerstin Hofer</strong>, Matrix & Science Lead,<strong> Roche</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">12.00 pm</span> </strong></span><strong>Showcasing Enhanced Tumour Penetration & Activity of Antibody Fragment Conjugates Using Novel Site-Specific Conjugation</strong></p> <p>• Introducing novel site-specific conjugation technology allowing one-step conjugation and simplification of in process testing<br /> • Applying one-step conjugation to antibody variable region to develop fragment-drug conjugates<br /> • Assessing increased tumour penetration and activity properties of fragment conjugates against HER2 and EGFR/cMET</p> <p><span style="color: #ac7194; font-size: 16px;"><strong>NingNing Ma</strong>, Professor,<strong> Shenyang Pharmaceutical University</strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>12.30 pm Lunch & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="color: #ac7194;"><strong><span style="color: #ac7194;">Two is Better Than One: Investigating Dual Target & Dual Payload ADC Design</span></strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">1.30 pm</span> Showcasing Target Rationale & Payload Selection Across Bispecific & Dual Payload ADC Development</strong></span></p> <p>• Outlining current challenges facing ADCs and opportunities for innovative design<br /> • Explaining target and format rationale selection in bispecific ADC development<br /> • Exploring payload selection and conjugation strategies for dual payload ADCs</p> <p><strong><span style="color: #ac7194;">Ming-Tain Lai</span></strong><span style="color: #ac7194;">, Chief Scientific Officer, </span><strong><span style="color: #ac7194;">OBI Pharma</span></strong></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">2.00 pm </span>ABL206 & ABL209: Bispecific ADC as Next Generation of ADC May Overcome Current Clinical Limitations</strong></span></p> <p>• Investigating synergistic cancer-killing effect by targeting two different targets on cancer cells<br /> • Outlining recent discovery research of bispecific ADC<br /> • Contrasting advantages and challenges of bispecific ADC development against traditional ADC design</p> <p><span style="font-size: 16px;"><strong><span style="color: #ac7194;">Jinwon Jung</span></strong><span style="color: #ac7194;">, Senior Director,</span><span style="color: #ac7194;"> Protein Engineering,</span><strong><span style="color: #ac7194;">ABL Bio</span></strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>2.30 pm Afternoon Break & Networking</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="2" tabindex="0"> <span><span style="color: #2b2a87; font-size: 16px;" id="Toxicity"><strong>2nd Toxicity Day</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-vo1itkx7ufer-panel-2" data-index="2" aria-hidden="true" aria-labelledby="fl-tabs-vo1itkx7ufer-label-2" role="tabpanel" aria-live="polite"> <p id="Toxicity" style="text-align: center;"><span style="color: #2b2a87; font-size: 16px;"><strong>2nd Toxicity Day</strong></span></p> <p style="text-align: center;"><span style="font-size: 16px;"><em><strong>Chair: </strong><strong>Rakesh Dixit</strong>, President & Chief Executive Officer,<strong> Bionavigen Oncology</strong></em></span></p> <p style="text-align: center;">Despite ADCs’ groundbreaking progress in oncology treatments; understanding, predicting and mitigating toxicity remains the great<br /> translational challenge stopping them from reaching patients faster. Don’t miss this seminar day to <strong>identify the mechanisms of on- and </strong><strong>off-target toxicity, leverage<em> in vitro</em> and <em>in vivo</em> models to predict ADC clinical safety, and understand the toxicity profiles of ADC with novel linker payloads and targets</strong></p> <p style="text-align: center;"><span style="font-size: 16px; color: #a91970;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/" data-feathr-click-track="true" data-feathr-link-aids="5dfbace0aab76b48e7dec78e"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="color: #2b2a87; font-size: 16px;"><strong>Characterising On & Off Target Toxicity to Develop Mitigation Strategies in the Clinic</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #2b2a87;">9.30 am</span> Demonstrating Importance & Explaining Best Methods to Understand ADC Toxicity Mechanisms</strong></span></p> <p>• Breaking down challenges in not fully understanding ADC toxicity mechanisms<br /> • Exploring the use of <em>in vitro</em> models to understand ADC lung and liver toxicity mechanism characterisation<br /> • What are the factors preventing the wider use of <em>in vitro</em> models in ADC toxicity studies?</p> <p><span style="color: #2b2a87; font-size: 16px;"><strong>Rakesh Dixit</strong>, President & Chief Executive Officer, <strong>Bionavigen Oncology</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #2b2a87;">10.00 am</span> Exploring the Correlation Between Toxicity & Linker Technologies for Topo1 Class ADCs</strong></span></p> <p>• Outlining a holistic review of early toxicity data associated with 2nd and 3rd generation linkers for Topo1 class ADCs<br /> • Exploring novel drug conjugate classes and target disease indications<br /> • Laying out Topo1 class ADC growth trend by geography</p> <p><span style="color: #2b2a87; font-size: 16px;"><strong>Callum Angus</strong>, Senior Market Analyst,<strong> Hanson Wade Intelligence</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #2b2a87;">10.30 am</span> Antibody-Drug Conjugates in Ovarian Cancer: Pioneering a New Era in Targeted Therapy</strong></span></p> <p>• A variety of therapeutic targets with high expression in ovarian cancer, combined with different payloads, is currently being evaluated to bring a wide range of opportunities to patients<br /> • The therapeutic index (benefit/adverse effects) appears promising, positioning ADCs as a potential new standard of care in different settings of the disease<br /> • Large efforts have been made to establish mitigation and prevention strategies to manage potential toxicity</p> <p><span style="color: #2b2a87; font-size: 16px;"><strong>David Garcia Illescas</strong>, Medical Oncologist, Gynaecological Cancer Programme,<strong> University Hospital Vall d’Hebron</strong><strong><br /> </strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>11.00 am Morning Break & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="color: #2b2a87;"><strong>Contrasting Toxicity & Tolerability Profiles With Novel ADC Linker- Payloads & Targets</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #2b2a87;">11.30 am </span></strong></span><strong>Exploring Discovery & Preclinical Investigation of a Novel ADC Targeting Gastrointestinal Cancer</strong></p> <p>• Exploiting novel and underexplored targets to deliver potential first-in-class ADCs for gastrointestinal cancers<br /> • Understanding and managing the challenges and safety profile of on-target toxicities of GI targets<br /> • Widening the ADC therapeutic window by matching target biology with the linker-payload design</p> <p><span style="color: #2b2a87; font-size: 16px;"><strong>Martin Steegmaier</strong>, Chief Scientific Officer,<strong> SOTIO Biotech</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #2b2a87;">12.00 pm</span> Using Patient-Derived Organoids to Prioritise ADC Clinical Development & Derisk Early Toxicities</strong></span></p> <p>• Exploring how HUB Organoid Technology allows for the development of patient-derived organoids relevant with high fidelity to the original tumour<br /> • Discussing how HUB Organoids can be used to derisk the preclinical development of ADC, prioritise indications, uncover off-target toxicities, and complement your biomarker strategy<br /> • Assessing how the next frontier for Organoids in ADC will see mode of action studies being performed to optimize clinical candidates and prioritise patient selection</p> <p><span style="color: #2b2a87; font-size: 16px;"><strong>Eider Valle-Encinas</strong>, Scientific Business Development Manager,<strong> HUB Organoids</strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>12.30 pm Lunch & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="color: #2b2a87;"><strong>Leveraging Non-Clinical Studies to Best<br /> Predict ADC Toxicities</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #2b2a87;">1.30 pm</span> Reducing ADC Toxicity & Strategies to Increase ADC Tolerability</strong></span></p> <p>• Reviewing and understanding the drivers of on and off target ADC toxicities<br /> • Assessing the predictability of <em>in vivo</em> models to best replicate toxicities in the clinic<br /> • Managing ADC toxicity and diving into strategies to increase tolerability and therapeutic index</p> <p><strong><span style="color: #2b2a87;">Sarah-Jane Neuberth</span></strong><span style="color: #2b2a87;">, Group Leader In Vivo Biology,</span><strong><span style="color: #2b2a87;">Heidelberg Pharma</span></strong></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #2b2a87;">2.00 pm</span> Assessing Non-Clinical Safety Profile of M9140 & the Putative Mechanism Behind ILD</strong></span></p> <p>• The therapeutic window of ADCS remains challenging due to safety issues such as ILD observed with specific deruxtecan-based ADCs<br /> • The current safety data of M9140 from NHP models are discussed with special focus on the absence or presence of ILD with other antibody camptothecin-conjugates, for which a hypothetical pathogenic mechanism is postulated<br /> • M9140 is in clinical phase 1b/2 currently to investigate treatment of solid tumours overexpressing CEACAM5</p> <p><span style="color: #2b2a87; font-size: 16px;"><strong>Willem Sloot</strong>, Associate Director, Non-Clinical Drug Safety, <strong>Merck KGaA</strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>2.30 pm Afternoon Break & Networking</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="3" tabindex="0"> <span><span style="color: #e31e26; font-size: 16px;" id="PatientSelection"><strong>3rd ADCs in Combination Day</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-vo1itkx7ufer-panel-3" data-index="3" aria-hidden="true" aria-labelledby="fl-tabs-vo1itkx7ufer-label-3" role="tabpanel" aria-live="polite"> <p id="PatientSelection" style="text-align: center;"><span style="font-size: 16px;"><span style="color: #e31e26;"><strong>3rd ADCs in Combination Day</strong></span></span></p> <p style="text-align: center;"><span style="font-size: 16px;"><strong>Chair: <em>Sharsti Sandall, </em></strong><em>Senior Director, Research, ADC Programs,<strong> Pfizer</strong></em></span></p> <p style="text-align: center;">As the number of ADC combination therapies rapidly grows, smartly selecting the combination partner is critical for success. The right decision will help your ADC overcome resistance and best position it to reshape the standard of oncology care. Attend this seminar day<br /> for a breakdown of clinical stage ADCimmunotherapy performance, understand the rationale for selecting effective combination partners, and explore ADCs in sequence to counter resistance mechanisms</p> <p style="text-align: center;"><span style="font-size: 16px; color: #a91970;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/" data-feathr-click-track="true" data-feathr-link-aids="5dfbace0aab76b48e7dec78e"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 16px;"><span style="color: #e31e26;"><strong>Evaluating Clinical Stage ADCImmunotherapy<br /> Combinations & Performance</strong></span></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #e31e26;">9.30 am</span> Breaking Down Clinical Combination Therapy Data of Belantamab Mafodotin in Treatment of Relapsed or Refractory Multiple Myeloma</strong></span></p> <p>• Laying out the foundation to believe in combinations with Blenrep in Multiple Myeloma: BCMA target, MOA for Blenrep, and data from previous clinical trials<br /> • Assessing results from DREAMM7 and DREAMM8 study in Multiple Myeloma</p> <p><span style="color: #e31e26;"><strong>Joanna Opalinska</strong>, Senior Director, Clinical Development,<strong> GSK</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #e31e26;">10.00 am</span> Translational Learnings From Enhertu in HER2-Positive & HER2-Low Breast Cancer & Beyond: Providing Context for ADC Combinations</strong></span></p> <p>• Contextualising Enhertu translational data from DestinyBreast-03 and DestinyBreast-04 trials and beyond<br /> • Overlapping and distinct mechanisms relating to Enhertu activity for HER2-low vs. HER2-positive breast cancer<br /> • Translational rationale in the design of ADC combinations</p> <p><span style="color: #e31e26; font-size: 16px;"><strong>Aislyn Boran</strong>, Senior Director, Translational Strategy, <strong>Daiichi Sankyo</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #e31e26;">10.30 am</span> Cancer Immunotherapy Combined With ADCs: Exploiting Novel & Rational Combinations</strong></span></p> <p>• Combining cancer immunotherapy with ADCs: Independent action versus synergy<br /> • Cancer immunotherapy combined with ADCs: Combinations based on efficacy response<br /> • Does adding in chemotherapy provide additional benefit to cancer immunotherapy combined with ADC’s?</p> <p><span style="color: #e31e26; font-size: 16px;"><strong>Michael Chisamore</strong>, Executive Medical Director (Distinguished Scientist), Oncology Clinical Research, Early Development,<strong> MSD</strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>11.00 am Morning Break & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="color: #e31e26;"><strong>Delving Into ADC Immunotherapy Rationale & Mechanism – What Makes an Effective Pairing?</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #e31e26;">11:30 am</span> Laying Out Preclinical Investigation to Validate the Rationale for ADC-Immunotherapy Combinations</strong></span></p> <p>• Contextualising the landscape and future perspectives of ADC-immunotherapy combinations<br /> • Assessing preclinical combination thesis: what are the best agents to combine with ADCs?<br /> • Breaking down preclinical investigation and use of models to understand ADC-immunotherapy mechanism and rationale</p> <p><span style="color: #e31e26; font-size: 16px;"><strong>Irena Adkins</strong>, Director, Pharmacology, <strong>SOTIO Biotech</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #e31e26;">12:00 pm</span> Investigating ADC Biomarkers to Optimise<br /> Clinical Trials & Evaluate ADC-Immunotherapy<br /> Combinations</strong></span></p> <p>• Exploring genomic biomarkers to inform ADC patient selection and precision oncology clinical development<br /> • Leveraging real world data to investigate genomic signatures and retrospectively identify enriched patient populations<br /> • Understanding biomarkers to identify synergy in ADC-immunotherapy combinations</p> <p><strong><span style="color: #e31e26;">Alireza Tafazzol</span></strong><span style="color: #e31e26;">, Senior Scientist II, Oncology </span><span style="color: #e31e26;">Bioinformatics,</span><strong><span style="color: #e31e26;"> AbbVie</span></strong></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>12.30 pm Lunch & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="color: #e31e26;"><strong>Exploring Benefits of Sequential ADC Combinations to Tackle Patient Resistance</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #e31e26;">1:30 pm</span> Rational Selection of Antibody-Drug Conjugates for Tumours Expressing Multiple Receptors</strong></span></p> <p>• Outlining how as more ADCs are clinically approved, patients eligible for 2 or more ADCs will become more frequent, leading to decisions on treatment selection<br /> • Discussing how average expression levels of the targets are important, but how antigen heterogeneity can also play a role<br /> • Showcasing a rational framework for predicting the efficacy of ADCs against different targets in the same tumour to guide preclinical and clinical studies</p> <p><strong><span style="color: #e31e26;">Greg Thurber</span></strong><span style="color: #e31e26;">, Associate Professor & Chair, Graduate </span><span style="color: #e31e26;">Education, </span><strong><span style="color: #e31e26;">University of Michigan</span></strong></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #e31e26;">2:00 pm</span> Roundtable Discussion: What Are the Benefits & Limitations of ADC Combinations?</strong></span></p> <p>• Discussing and debating the potential of dual payloads and ADC therapy sequences to help combat ADC patient resistance<br /> • What are the lessons learnt from ongoing clinical stage ADC combination trials?<br /> • Evaluating the best strategic approaches to select ADC combination partners with rationale and evidence-based decision-making</p> <p><span style="color: #e31e26;"><strong>Sharsti Sandall</strong>, Executive Director, Oncology Research</span><span style="color: #e31e26;">, </span><strong><span style="color: #e31e26;">Pfizer</span></strong></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>2.30 pm Afternoon Break & Networking</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="4" tabindex="0"> <span><span style="color: #990582; font-size: 16px;" id="Bioanalytical"><strong>1st Regulatory CMC Day</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-vo1itkx7ufer-panel-4" data-index="4" aria-hidden="true" aria-labelledby="fl-tabs-vo1itkx7ufer-label-4" role="tabpanel" aria-live="polite"> <p id="Bioanalytical" style="text-align: center;"><span style="font-size: 16px;"><strong><span style="color: #990582;">1st Regulatory CMC Day</span></strong></span></p> <p style="text-align: center;"><span style="font-size: 16px;"><em><strong>Chair: </strong><strong>Colm Reddington</strong>, Senior Director, Global Regulatory CMC, <strong>AstraZeneca</strong></em></span></p> <p style="text-align: center;">As ADCs globally advance quickly towards regulatory submissions; understanding the necessary specifications, dossier filing data, and evolving regulatory attitudes is vital for successful approval and commercialisation. Join this redesigned seminar day to<strong> tackle ADC modality-specific challenges, streamline impurity control strategy, and discuss the important areas for ongoing industry regulator communication</strong></p> <p style="text-align: center;"><span style="color: #a91970; font-size: 16px;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 16px;"><strong><span style="color: #990582;">Tackling ADC Regulatory CMC Strategy as Intermediates Between Biologic & Small Molecules</span></strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #990582;">9.30 am</span> Understanding High-Level Regulatory Guidance for Linker-Payload, Monoclonal Antibody & Conjugate Control Strategy</strong></span></p> <p>• Introducing global regulatory attitudes and guidance for ADC component and conjugate control strategy<br /> • Approaching ADC regulatory CMC strategy as a biologic-small molecule intermediate<br /> • Highlighting experiences, challenges and lessons learnt in ADC control strategy development</p> <p><span style="color: #990582; font-size: 16px;"><strong>Colm Reddington</strong>, Senior Director, Global Regulatory CMC, <strong>AstraZeneca</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #990582;">10.00 am</span> Exploring Scientific Understanding & Analytical Control Strategy of ADC Heterogeneity</strong></span></p> <p>• Exploring how ADCs are composed of both small molecule and large molecule components and need additional points of analytical control and intensified characterisation<br /> • Outlining heterogeneities of ADCs including charge, size, post-translational modification variants, and DAR distribution originating from the mAb, drug-linker and the conjugation process<br /> • Discussing the inherent heterogeneity of ADC and the analytical control strategy</p> <p><span style="color: #990582; font-size: 16px;"><strong>Daisy Sun</strong>, Principal Scientist, Cell-Based Sciences,<strong> MSD</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #990582;">10.30 am</span> Perspectives on Regulatory CMC Strategies for Drug-Linkers in Antibody-Drug Conjugates</strong></span></p> <p>• Sharing IQ consortium proposals for regulatory considerations on drug-linker in ADC development, aiming to align drug linker development and regulatory expectations<br /> • Discussing perspectives on major regulatory strategies from practical, scientific and risk-based investigation from early development to registration<br /> • Addressing approaches to regulatory starting material designation, controls and control strategies, accelerated process validation, regulatory filing documentation, characterisation, and stability</p> <p><strong><span style="color: #990582;">Llorente Bonaga</span></strong><span style="color: #990582;">, Senior Director, Global Regulatory </span><span style="color: #990582;">Affairs & Clinical Safety, CMC, </span><strong><span style="color: #990582;">MSD</span></strong></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>11.00 am Morning Break & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 16px;"><strong><span style="color: #990582;">Contextualising ADC Regulatory CMC Attitudes & Debating Important Areas for Future Guidance</span></strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #990582;">11.30 am</span> Audience Activity Session: Discussing Challenges & Opportunities With Existing ADC Regulatory CMC Legislation & Data Submissions</strong></span></p> <p>Maintaining constructive bi-directional communication<br /> between sponsors and regulators is crucial for successful ADC approval and commercialisation as a unique and emerging modality.</p> <p>Join individual table discussions moderated by ADC<br /> regulatory CMC leaders with prepared discussion<br /> points surrounding the opportunities and setbacks of<br /> global regulatory guidance. Make sure you come with<br /> your thoughts and questions prepared!</p> <p><strong>Discussion highlights include:</strong><br /> • Evaluating the challenges of preparing for ADC regulatory submissions under accelerated timelines with limited manufacturing experience<br /> • Comparing and contrasting the ADC regulatory CMC across global health authorities<br /> • Debating the sponsor perspective – what are the top areas to prioritise for future industry-regulator interactions</p> <p><span style="color: #990582; font-size: 16px;"><strong>Hayley Jackman</strong>, Director, CMC Regulatory Affairs, <strong>AstraZeneca</strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>12.30 pm Lunch & Networking</strong></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 16px;"><strong><span style="color: #990582;">Ensuring Internal & External Alignment to Streamline ADC Regulatory CMC Strategy Execution</span></strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #990582;">1.30 pm</span> Explaining the Importance of Collaboration Across Organisations & Partners to Create an Integrated ADC Development Package</strong></span></p> <p>• Creating a drug linker platform approach for multiple ADCs<br /> • Leveraging expertise across organisations to develop an integrated plan and control strategy<br /> • Organising internal and external stakeholders for success</p> <p><span style="color: #990582; font-size: 16px;"><strong>Alex Robertson</strong>, Executive Director, CMC Project Management,<strong> AstraZeneca</strong></span></p> <hr /> <p><span style="font-size: 16px;"><strong><span style="color: #990582;">2.00 pm</span> Roundtable Discussion: What are the Key Opportunities for Success & Improvement in ADC Regulatory CMC?</strong></span></p> <p>Join this closing roundtable session with leaders in ADC regulatory CMC field to break down the key learnings from the seminar day. With your fellow speakers and attendees, discuss, debate and evaluate the opportunities and challenges in ADC regulatory CMC guidance, analytical control strategy, creating development packages, and more.</p> <p><span style="color: #990582; font-size: 16px;"><strong>Colm Reddington</strong>, Senior Director, Global Regulatory CMC, <strong>AstraZeneca</strong></span></p> <hr /> <p><span style="color: #f9af1f; font-size: 16px;"><strong>2.30 pm Afternoon Break & Networking</strong></span></p> </div> </div> </div> </div> </div> </div> <div class="fl-module fl-module-ee-agenda fl-node-0pmokf67w98e" data-node="0pmokf67w98e"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:00 pm </span> ADC Licensing, Partnering & Investment Session </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23808" class="view-speaker" speaker-id="23808"><span>Jiazhen Chen</span></a></em> Director, External Innovation, BioNTech </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23809" class="view-speaker" speaker-id="23809"><span>Maria Dahl</span></a></em> Chief Operating Officer & Head of Innovent Biologics, Innovent Biologics </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23810" class="view-speaker" speaker-id="23810"><span>Kurt Pike</span></a></em> Senior Director - External Innovation, Johnson & Johnson </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23811" class="view-speaker" speaker-id="23811"><span>Benjamin Thomas</span></a></em> Senior Vice President, External Innovation, Oxford BioTherapeutics </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23812" class="view-speaker" speaker-id="23812"><span>Jon Travers</span></a></em> Senior Director, Ipsen </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23813" class="view-speaker" speaker-id="23813"><span>Xiaona Jing</span></a></em> SVP Global Product Development & Partnering, Multitude Therapeutics </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23814" class="view-speaker" speaker-id="23814"><span>Norbert Prenzel</span></a></em> Head of Business Development & Licensing, SOTIO Biotech </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23815" class="view-speaker" speaker-id="23815"><span>Lucas Donigian</span></a></em> VP BD, Zymeworks </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>It’s no secret that ADCs have firmly positioned themselves at the forefront of oncology R&D and dealmaking. <strong>The total value of ADCs peaked at $167 billion in 2023</strong>, representing rampant billion-dollar partnerships and M&As from Pfizer, AbbVie, J&J, Merck, Genmab, Ipsen and beyond, and a bulk of Series A VC transactions highlighting a boom of new ADC companies forming.</p> <p></p> <p>As the leaders of the global pharmaceutical world look for a piece of the ADC pie, it is crucial to understand what innovation, data and risktaking criteria are fuelling the partnerships, licensing deals, and investment amongst ADC stakeholders.</p> <p></p> <p>Exclusively designed for <strong>search and evaluation</strong>, <strong>early innovation</strong>, and <strong>business development leads</strong>, <strong>C-level biotech leaders</strong>, and <strong>VC biopharma investors</strong>, join to be part of an insightful panel session followed by a unique networking space to foster new relationships for ADC collaboration, partnerships and investment ahead of the main conference days.</p> <p></p> <p>Register your interest when you sign up to attend the conference, then look out for an email to secure your spot!</p> <p></p> <p><strong>Panel Discussion Highlights:</strong></p> <p></p> <p>• Breaking down big pharma’s heavy investment into ADCs: what is the reasoning and level of risk behind recent mergers and acquisitions (M&As), and licensing deals?</p> <p>• Laying out the lessons learnt from recent big pharma licensing and M&As – what can we expect after the blockbuster deals?</p> <p>• Understanding the out-licensing perspective to breakdown required data, level of risk, and differentiating factors when from recent ADC partnerships and collaborations</p> <p>• Taking a step back and evaluating the global state of the ADC field – what are predictions for where the ADC field will be in 3-5 years?</p> <p>• Discussing how biotechs can be best positioned to stay ahead of the market innovation</p> <p></p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> End of Pre-Conference Seminar Day </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> <div class="fl-col-group fl-node-pxyh608fl5qk fl-col-group-nested" data-node="pxyh608fl5qk"> <div 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$(nestedCols).each(function(index,col){if($(col).width()<=0){$(col).css('width',FLBuilderLayoutConfig.emptyColWidth);}});},_adjustRowShapeLayerHeight:function(){var rowShapeLayers=$('.fl-builder-shape-layer');$(rowShapeLayers).each(function(index){var rowShapeLayer=$(this),shape=$(rowShapeLayer).find('svg'),height=shape.height(),excludeShapes='.fl-builder-shape-circle, .fl-builder-shape-dot-cluster, .fl-builder-shape-topography, .fl-builder-shape-rect';if(!rowShapeLayer.is(excludeShapes)){$(shape).css('height',Math.ceil(height));}});},_string_to_slug:function(str){str=str.replace(/^\s+|\s+$/g,'');if('undefined'==typeof window._fl_string_to_slug_regex){regex=new RegExp('[^a-zA-Z0-9\'":() !.,-_|]','g');}else{regex=new RegExp('[^'+window._fl_string_to_slug_regex+'\'": !.,-_|\\\p{Letter}]','ug');} str=str.replace(regex,'').replace(/\s+/g,' ');return str;},_reorderMenu:function(){if($('#wp-admin-bar-fl-builder-frontend-edit-link-default li').length>1){$('#wp-admin-bar-fl-builder-frontend-duplicate-link').appendTo('#wp-admin-bar-fl-builder-frontend-edit-link-default').css('padding-top','5px').css('border-top','2px solid #1D2125').css('margin-top','5px')}}};$(function(){FLBuilderLayout.init();});})(jQuery);;(function($){FLBuilderTabs=function(settings){this.settings=settings;this.nodeClass='.fl-node-'+settings.id;this.tabsOnMobile=settings.tabsOnMobile;this.activeTab=settings.activeTab;this._init();};FLBuilderTabs.prototype={settings:{},nodeClass:'',_init:function(){var win=$(window);$(this.nodeClass+' .fl-tabs-labels .fl-tabs-label').click($.proxy(this._labelClick,this));$(this.nodeClass+' .fl-tabs-labels .fl-tabs-label').on('keypress',$.proxy(this._labelClick,this));$(this.nodeClass+' .fl-tabs-panels .fl-tabs-label').click($.proxy(this._responsiveLabelClick,this));$(this.nodeClass+' .fl-tabs-panels .fl-tabs-label').on('keypress',$.proxy(this._responsiveLabelClick,this));win.on('resize',$.proxy(this._setupTabs,this));if($(this.nodeClass+' .fl-tabs-vertical').length>0){this._resize();win.off('resize'+this.nodeClass);win.on('resize'+this.nodeClass,$.proxy(this._resize,this));} FLBuilderLayout.preloadAudio(this.nodeClass+' .fl-tabs-panel-content');this._setupTabs();},_labelClick:function(e){var label=$(e.target).closest('.fl-tabs-label'),index=label.data('index'),wrap=label.closest('.fl-tabs'),allIcons=wrap.find('.fl-tabs-panels .fl-tabs-label .fas'),icon=wrap.find('.fl-tabs-panels .fl-tabs-label[data-index="'+index+'"] .fas');if(!this._validClick(e)){return;} allIcons.addClass('fa-plus');icon.removeClass('fa-plus');wrap.find('.fl-tabs-labels:first > .fl-tab-active').removeClass('fl-tab-active').attr('aria-selected','false').attr('aria-expanded','false');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tab-active').removeClass('fl-tab-active');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content').attr('aria-hidden','true').css('display','');wrap.find('.fl-tabs-labels:first > .fl-tabs-label[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-selected','true').attr('aria-expanded','true');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-label[data-index="'+index+'"]').addClass('fl-tab-active');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-hidden','false');FLBuilderLayout.refreshGalleries(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.refreshGridLayout(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.reloadSlider(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.resizeAudio(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.resizeSlideshow();FLBuilderLayout.reloadGoogleMap(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));e.preventDefault();},_responsiveLabelClick:function(e){var label=$(e.target).closest('.fl-tabs-label'),wrap=label.closest('.fl-tabs'),index=label.data('index'),content=label.siblings('.fl-tabs-panel-content'),activeContent=wrap.find('.fl-tabs-panel-content.fl-tab-active'),activeIndex=activeContent.data('index'),allIcons=wrap.find('.fl-tabs-panels .fl-tabs-label > .fas'),icon=label.find('.fas');if(!this._validClick(e)){return;} if(label.hasClass('fl-tab-active')||wrap.hasClass('fl-tabs-animation')){return;} allIcons.addClass('fa-plus');icon.removeClass('fa-plus');wrap.addClass('fl-tabs-animation');activeContent.slideUp('normal');content.slideDown('normal',function(){wrap.find('.fl-tab-active').removeClass('fl-tab-active').attr('aria-hidden','true');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content').attr('aria-hidden','true');wrap.find('.fl-tabs-label[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-hidden','false');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content[data-index="'+index+'"]').attr('aria-hidden','false');content.addClass('fl-tab-active');wrap.removeClass('fl-tabs-animation');FLBuilderLayout.refreshGalleries(content);FLBuilderLayout.refreshGridLayout(content);FLBuilderLayout.reloadSlider(content);FLBuilderLayout.resizeAudio(content);FLBuilderLayout.reloadGoogleMap(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));if(label.offset().top<$(window).scrollTop()+100){$('html, body').animate({scrollTop:label.offset().top-100},500,'swing');}});},_resize:function(){$(this.nodeClass+' .fl-tabs-vertical').each($.proxy(this._resizeVertical,this));},_resizeVertical:function(e){var wrap=$(this.nodeClass+' .fl-tabs-vertical'),labels=wrap.find('.fl-tabs-labels'),panels=wrap.find('.fl-tabs-panels');panels.css('min-height',labels.height()+'px');},_validClick:function(e){return(e.which==1||e.which==13||e.which==32)?true:false;},_setupTabs:function(){index=this.activeTab-1;if(index<0){index=0;} var winWidth=$(window).width(),activeTabContent=$(this.nodeClass+' .fl-tabs-panel-content.fl-tab-active'),activeTabPanel=activeTabContent.parent(),activeTabLabelIcon=activeTabPanel.find('i'),smallBreakPoint=FLBuilderLayoutConfig.breakpoints.small,mediumBreakPoint=FLBuilderLayoutConfig.breakpoints.medium;if(winWidth<=smallBreakPoint&&'close-all'==this.tabsOnMobile){activeTabContent.hide();activeTabLabelIcon.addClass('fa-plus');activeTabPanel.find('.fl-tab-active').removeClass('fl-tab-active').attr('aria-hidden','true');}else if(winWidth>=smallBreakPoint){activeTabContent.show();activeTabLabelIcon.removeClass('fa-plus');}},};})(jQuery);;(function($){$(function(){new FLBuilderTabs({id:'vo1itkx7ufer',tabsOnMobile:'open-active',activeTab:'1',});});})(jQuery);;;;(function($){FLBuilderMenu=function(settings){this.nodeId=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-menu';this.type=settings.type;this.mobileToggle=settings.mobile;this.mobileBelowRow=settings.mobileBelowRow;this.mobileFlyout=settings.mobileFlyout;this.breakPoints=settings.breakPoints;this.mobileBreakpoint=settings.mobileBreakpoint;this.currentBrowserWidth=$(window).width();this.postId=settings.postId;this.mobileStacked=settings.mobileStacked;this._initMenu();$(window).on('resize',$.proxy(function(e){var width=$(window).width();if(width!=this.currentBrowserWidth){this.currentBrowserWidth=width;this._initMenu();this._clickOrHover();} this._resizeFlyoutMenuPanel();},this));$(window).on('scroll',$.proxy(function(e){this._resizeFlyoutMenuPanel();},this));$('body').on('click',$.proxy(function(e){if('undefined'!==typeof FLBuilderConfig){return;} var activeMobileMenu=$(this.wrapperClass+' .fl-menu-mobile-toggle.fl-active');if(activeMobileMenu.length&&('expanded'!==this.mobileToggle)){$(activeMobileMenu).trigger('click');} $(this.wrapperClass).find('.fl-has-submenu').removeClass('focus');$(this.wrapperClass).find('.fl-has-submenu .sub-menu').removeClass('focus');},this));$(this.wrapperClass+' ul.menu > li:last-child').on('focusout',$.proxy(function(e){if($(this.wrapperClass).find('.fl-menu-mobile-toggle').hasClass('fl-active')&&('expanded'!==this.mobileToggle)){if(!$(e.relatedTarget).parent().hasClass('menu-item')){$(this.wrapperClass).find('.fl-menu-mobile-toggle').trigger('click');}}},this));};FLBuilderMenu.prototype={nodeClass:'',wrapperClass:'',type:'',breakPoints:{},$submenus:null,_isMobile:function(){return this.currentBrowserWidth<=this.breakPoints.small?true:false;},_isMedium:function(){return this.currentBrowserWidth<=this.breakPoints.medium?true:false;},_isLarge:function(){return this.currentBrowserWidth<=this.breakPoints.large?true:false;},_isMenuToggle:function(){if(('always'==this.mobileBreakpoint||(this._isMobile()&&'mobile'==this.mobileBreakpoint)||(this._isMedium()&&'medium-mobile'==this.mobileBreakpoint)||(this._isLarge()&&'large-mobile'==this.mobileBreakpoint))&&($(this.wrapperClass).find('.fl-menu-mobile-toggle').is(':visible')||'expanded'==this.mobileToggle)){return true;} return false;},_initMenu:function(){this._setupSubmenu();this._menuOnFocus();this._menuOnEscape();this._submenuOnClick();if($(this.nodeClass).length&&this.type=='horizontal'){this._initMegaMenus();} if(this._isMenuToggle()||this.type=='accordion'){$(this.wrapperClass).off('mouseenter mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').find('a').first().attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5ba0ab906f568',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'198',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-5ba0ae36c560f .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-5df7a79c323db .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){$(function(){new FLBuilderMenu({id:'5df7a7db5b61b',type:'accordion',mobile:'hamburger',mobileBelowRow:false,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'always',postId:'198',mobileStacked:true,});});})(jQuery);;;var FLBuilderCountdown;var FLBuilderCountdownIntervals=FLBuilderCountdownIntervals||[];(function($){FLBuilderCountdown=function(settings){this.nodeID=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-countdown';this.dateWrapper=this.nodeClass+' .fl-countdown-days';this.dateLabel=$(this.dateWrapper+' .fl-countdown-unit-label').data('label');this.hoursWrapper=this.nodeClass+' .fl-countdown-hours';this.hoursLabel=$(this.hoursWrapper+' .fl-countdown-unit-label').data('label');this.minutesWrapper=this.nodeClass+' .fl-countdown-minutes';this.minutesLabel=$(this.minutesWrapper+' .fl-countdown-unit-label').data('label');this.secondsWrapper=this.nodeClass+' .fl-countdown-seconds';this.secondsLabel=$(this.secondsWrapper+' .fl-countdown-unit-label').data('label');this.timestamp=settings.time;this.type=settings.type;this.redirect=settings.redirect;this.redirect_url=settings.redirect_url;this._initCountdown();};FLBuilderCountdown.prototype={nodeClass:'',wrapperClass:'',countdown:'',dateWrapper:'',dateLabel:'',hoursWrapper:'',hoursLabel:'',minutesWrapper:'',minutesLabel:'',secondsWrapper:'',secondsLabel:'',timestamp:'',_getTimeRemaining:function(endtime){var t=Date.parse(endtime)-Date.parse(new Date());var seconds=Math.floor((t/1000)%60);var minutes=Math.floor((t/1000/60)%60);var hours=Math.floor((t/(1000*60*60))%24);var days=Math.floor(t/(1000*60*60*24));return{'total':t,'days':(days<10)?('0'+days):days,'hours':('0'+hours).slice(-2),'minutes':('0'+minutes).slice(-2),'seconds':('0'+seconds).slice(-2)};},_setTimeRemaining:function(shouldRedirect){var 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t=this._getTimeRemaining(this.timestamp),max={days:365,hours:24,minutes:60,seconds:60},circles={days:$(this.dateWrapper).find('svg'),hours:$(this.hoursWrapper).find('svg'),minutes:$(this.minutesWrapper).find('svg'),seconds:$(this.secondsWrapper).find('svg'),} $.each(circles,function(type,element){var $circle=element.find('.fl-number'),r=$circle.attr('r'),circle=Math.PI*(r*2),val=t[type],total=max[type],stroke=(1-(val / total))*circle;$circle.css({strokeDashoffset:stroke});});},_initCountdown:function(){var self=this;if(0===$(this.wrapperClass).length){return;} clearInterval(FLBuilderCountdownIntervals[this.nodeID]);FLBuilderCountdownIntervals[this.nodeID]=setInterval(function(){self._setTimeRemaining(true);if(self.type=='circle'){self._setCircleCount();}},1000);this._setTimeRemaining('always'===self.redirect);if(this.type=='circle'){this._setCircleCount();}},};})(jQuery);;(function($){$(function(){new FLBuilderCountdown({id:'zij0kf1ax2wn',time:'2025-03-03T08:00:00+00:00',type:'circle',redirect:'disabled',redirect_url:'',});});})(jQuery);;;(function($){$(function(){new FLBuilderCountdown({id:'pou3ks5vc0wl',time:'2025-03-03T08:00:00+00:00',type:'circle',redirect:'disabled',redirect_url:'',});});})(jQuery);(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var 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if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} 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