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Animals Research Papers - Academia.edu

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This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_58551895" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient and / or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. In this setting we provide a narrative review, to a...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58551895" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f1cc05245eb69cf5cce944bdbdf9648b" rel="nofollow" data-download="{&quot;attachment_id&quot;:72909037,&quot;asset_id&quot;:58551895,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72909037/download_file?st=MTczMjM4NjA1Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="117217188" href="https://independent.academia.edu/meredithsheil">meredith sheil</a><script data-card-contents-for-user="117217188" type="text/json">{"id":117217188,"first_name":"meredith","last_name":"sheil","domain_name":"independent","page_name":"meredithsheil","display_name":"meredith sheil","profile_url":"https://independent.academia.edu/meredithsheil?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_58551895 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58551895"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58551895, container: ".js-paper-rank-work_58551895", }); });</script></li><li class="js-percentile-work_58551895 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 58551895; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_58551895"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_58551895 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="58551895"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 58551895; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=58551895]").text(description); $(".js-view-count-work_58551895").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_58551895").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="58551895"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a><script data-card-contents-for-ri="99234" type="text/json">{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=58551895]'), work: {"id":58551895,"title":"Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration","created_at":"2021-10-17T02:12:40.534-07:00","url":"https://www.academia.edu/58551895/Optimal_Methods_of_Documenting_Analgesic_Efficacy_in_Neonatal_Piglets_Undergoing_Castration?f_ri=99234","dom_id":"work_58551895","summary":"Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient and / or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. 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href="https://www.academia.edu/43086835/Feline_leukemia_virus_immunity_induced_by_whole_inactivated_virus_vaccination">Feline leukemia virus immunity induced by whole inactivated virus vaccination</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/43086835" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1e75bc7c28d229a3fcd41e3de5b97b21" rel="nofollow" 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tissues</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11378718" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b2269243f6cf5810908823e0b4067d00" rel="nofollow" data-download="{&quot;attachment_id&quot;:46742919,&quot;asset_id&quot;:11378718,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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href="https://www.academia.edu/Documents/in/Mice">Mice</a><script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=903598]'), work: {"id":903598,"title":"Embryonic stem cell specific microRNAs promote induced pluripotency","created_at":"2011-09-10T12:34:08.271-07:00","url":"https://www.academia.edu/903598/Embryonic_stem_cell_specific_microRNAs_promote_induced_pluripotency?f_ri=99234","dom_id":"work_903598","summary":null,"downloadable_attachments":[{"id":32403711,"asset_id":903598,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":721599,"first_name":"Robert","last_name":"Judson","domain_name":"ucsf","page_name":"RobertJudson","display_name":"Robert 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href="https://www.academia.edu/31091000/Imaging_of_Caenorhabditis_elegans_neurons_by_second_harmonic_generation_and_two_photon_excitation_fluorescence">Imaging of Caenorhabditis elegans neurons by second-harmonic generation and two-photon excitation fluorescence</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31091000" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a235652e0811f457915afff8c9e6b043" rel="nofollow" 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class="InlineList-item-text" data-has-card-for-ri="2889" href="https://www.academia.edu/Documents/in/Caenorhabditis_elegans">Caenorhabditis elegans</a>,&nbsp;<script data-card-contents-for-ri="2889" type="text/json">{"id":2889,"name":"Caenorhabditis elegans","url":"https://www.academia.edu/Documents/in/Caenorhabditis_elegans?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5493" href="https://www.academia.edu/Documents/in/Nonlinear_dynamics">Nonlinear dynamics</a>,&nbsp;<script data-card-contents-for-ri="5493" type="text/json">{"id":5493,"name":"Nonlinear dynamics","url":"https://www.academia.edu/Documents/in/Nonlinear_dynamics?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7698" href="https://www.academia.edu/Documents/in/Fluorescence">Fluorescence</a><script data-card-contents-for-ri="7698" 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js-work-card work_58102458" data-work_id="58102458" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/58102458/Cardiac_implications_of_Lyme_disease_diagnosis_and_therapeutic_approach">Cardiac implications of Lyme disease, diagnosis and therapeutic approach</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58102458" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2efd9509eac172f8102bd8e3bfe99260" 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18347937" data-work_id="18347937" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18347937/Proliferation_of_masseter_myocytes_after_distraction_osteogenesis_of_the_porcine_mandible">Proliferation of masseter myocytes after distraction osteogenesis of the porcine mandible</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Long-term success of distraction osteogenesis depends on the ability of the surrounding soft tissues to tolerate distraction forces and to adapt to the resulting increase in skeletal length and volume. The hypothesis tested in this study... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18347937" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Long-term success of distraction osteogenesis depends on the ability of the surrounding soft tissues to tolerate distraction forces and to adapt to the resulting increase in skeletal length and volume. The hypothesis tested in this study was that mandibular elongation by distraction induces myocyte proliferation. Unilateral mandibular angle osteotomies were performed in 16 Yucatan minipigs. The hemimandibles were lengthened using semiburied distraction devices (Synthes Maxillofacial, Paoli, PA) with 0-day latency, 1, 2, or 4 mm/d distraction rates, and a neutral fixation period of twice the gap size in days. In 2 additional animals, the dissection and osteotomies were performed, and distraction devices were placed without activation (sham control). At the end of neutral fixation, tissues were taken from masseter muscle overlying the osteotomy and the equivalent region on the unoperated side (contralateral control). Proliferation of myocytes was estimated using immunohistochemical localization with antibodies against proliferating cell nuclear antigen (PCNA). Muscle overlying the distracted mandible showed 6-fold more PCNA-positive myocytes (16.8% +/- 11.3%) than the contralateral control side (2.8% +/- 1.1%, P &amp;amp;lt; .0001). In the 2 sham-control animals, there was a low index of PCNA-positive myocytes on both the osteotomy (2%, 5%) and the contralateral sides (1%, 2%). The results of this study suggest that distraction of the porcine mandible by the protocol described induces myocyte proliferation in the masseter muscle. A proliferative response may contribute to improved long-term stability of mandibular expansion by distraction osteogenesis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18347937" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fdca690237e5635201e675117ffe536b" rel="nofollow" data-download="{&quot;attachment_id&quot;:42175855,&quot;asset_id&quot;:18347937,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42175855/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38335397" href="https://independent.academia.edu/LeonardKaban">Leonard Kaban</a><script data-card-contents-for-user="38335397" type="text/json">{"id":38335397,"first_name":"Leonard","last_name":"Kaban","domain_name":"independent","page_name":"LeonardKaban","display_name":"Leonard Kaban","profile_url":"https://independent.academia.edu/LeonardKaban?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18347937 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18347937"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18347937, container: ".js-paper-rank-work_18347937", }); 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$(".js-view-count[data-work-id=18347937]").text(description); $(".js-view-count-work_18347937").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18347937").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18347937"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">16</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="596" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>,&nbsp;<script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3243" href="https://www.academia.edu/Documents/in/Nonparametric_Statistics">Nonparametric Statistics</a>,&nbsp;<script data-card-contents-for-ri="3243" type="text/json">{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12071" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>,&nbsp;<script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38650" href="https://www.academia.edu/Documents/in/Cell_Division">Cell Division</a><script data-card-contents-for-ri="38650" type="text/json">{"id":38650,"name":"Cell Division","url":"https://www.academia.edu/Documents/in/Cell_Division?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18347937]'), work: {"id":18347937,"title":"Proliferation of masseter myocytes after distraction osteogenesis of the porcine mandible","created_at":"2015-11-14T13:54:28.172-08:00","url":"https://www.academia.edu/18347937/Proliferation_of_masseter_myocytes_after_distraction_osteogenesis_of_the_porcine_mandible?f_ri=99234","dom_id":"work_18347937","summary":"Long-term success of distraction osteogenesis depends on the ability of the surrounding soft tissues to tolerate distraction forces and to adapt to the resulting increase in skeletal length and volume. 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Muscle overlying the distracted mandible showed 6-fold more PCNA-positive myocytes (16.8% +/- 11.3%) than the contralateral control side (2.8% +/- 1.1%, P \u0026amp;lt; .0001). In the 2 sham-control animals, there was a low index of PCNA-positive myocytes on both the osteotomy (2%, 5%) and the contralateral sides (1%, 2%). The results of this study suggest that distraction of the porcine mandible by the protocol described induces myocyte proliferation in the masseter muscle. A proliferative response may contribute to improved long-term stability of mandibular expansion by distraction osteogenesis.","downloadable_attachments":[{"id":42175855,"asset_id":18347937,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38335397,"first_name":"Leonard","last_name":"Kaban","domain_name":"independent","page_name":"LeonardKaban","display_name":"Leonard Kaban","profile_url":"https://independent.academia.edu/LeonardKaban?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=99234","nofollow":false},{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=99234","nofollow":false},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=99234","nofollow":false},{"id":38650,"name":"Cell 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href="https://www.academia.edu/31966396/Scilla_maderensis_TLC_screening_and_positive_inotropic_effect_of_bulb_extracts">Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31966396" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="81dbf43298f65e2f57d0ab1caf1aa659" rel="nofollow" data-download="{&quot;attachment_id&quot;:52240372,&quot;asset_id&quot;:31966396,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52240372/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33372142" 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Medicine</a>,&nbsp;<script data-card-contents-for-ri="4083" type="text/json">{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5541" href="https://www.academia.edu/Documents/in/Plant_Biology">Plant Biology</a>,&nbsp;<script data-card-contents-for-ri="5541" type="text/json">{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="14032" href="https://www.academia.edu/Documents/in/Ethnopharmacology">Ethnopharmacology</a><script data-card-contents-for-ri="14032" type="text/json">{"id":14032,"name":"Ethnopharmacology","url":"https://www.academia.edu/Documents/in/Ethnopharmacology?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=31966396]'), work: {"id":31966396,"title":"Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts","created_at":"2017-03-21T10:16:05.564-07:00","url":"https://www.academia.edu/31966396/Scilla_maderensis_TLC_screening_and_positive_inotropic_effect_of_bulb_extracts?f_ri=99234","dom_id":"work_31966396","summary":null,"downloadable_attachments":[{"id":52240372,"asset_id":31966396,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33372142,"first_name":"Catarina","last_name":"Dias","domain_name":"fful","page_name":"CatarinaDias","display_name":"Catarina Dias","profile_url":"https://fful.academia.edu/CatarinaDias?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=99234","nofollow":false},{"id":4083,"name":"Complementary and Alternative 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Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro?f_ri=99234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=99234"},{"id":219827,"name":"Endemic","url":"https://www.academia.edu/Documents/in/Endemic?f_ri=99234"},{"id":309895,"name":"Isolation","url":"https://www.academia.edu/Documents/in/Isolation?f_ri=99234"},{"id":312834,"name":"Cardiovascular system","url":"https://www.academia.edu/Documents/in/Cardiovascular_system?f_ri=99234"},{"id":354056,"name":"Plant extracts","url":"https://www.academia.edu/Documents/in/Plant_extracts?f_ri=99234"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity?f_ri=99234"},{"id":789968,"name":"Extract","url":"https://www.academia.edu/Documents/in/Extract?f_ri=99234"},{"id":880186,"name":"Vulnerable","url":"https://www.academia.edu/Documents/in/Vulnerable?f_ri=99234"},{"id":888739,"name":"Quntitative Thin Layer Chromatography","url":"https://www.academia.edu/Documents/in/Quntitative_Thin_Layer_Chromatography?f_ri=99234"},{"id":971822,"name":"Active Ingredient","url":"https://www.academia.edu/Documents/in/Active_Ingredient?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21651075" data-work_id="21651075" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21651075/Heart_specific_up_regulation_of_genes_for_B_type_and_C_type_natriuretic_peptide_receptors_in_diabetic_mice">Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21651075" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5f7606cf65a19c4f4c692eeb51e5d7d4" rel="nofollow" data-download="{&quot;attachment_id&quot;:42292249,&quot;asset_id&quot;:21651075,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42292249/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32490701" href="https://independent.academia.edu/ChristoffersenC">C. Christoffersen</a><script data-card-contents-for-user="32490701" type="text/json">{"id":32490701,"first_name":"C.","last_name":"Christoffersen","domain_name":"independent","page_name":"ChristoffersenC","display_name":"C. Christoffersen","profile_url":"https://independent.academia.edu/ChristoffersenC?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21651075 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21651075"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21651075, container: ".js-paper-rank-work_21651075", }); });</script></li><li class="js-percentile-work_21651075 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21651075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21651075"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21651075 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21651075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21651075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21651075]").text(description); $(".js-view-count-work_21651075").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21651075").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21651075"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">10</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="84760" href="https://www.academia.edu/Documents/in/Mice">Mice</a>,&nbsp;<script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a>,&nbsp;<script data-card-contents-for-ri="99234" type="text/json">{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="111545" href="https://www.academia.edu/Documents/in/Male">Male</a>,&nbsp;<script data-card-contents-for-ri="111545" type="text/json">{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="116889" href="https://www.academia.edu/Documents/in/Natriuretic_Peptides">Natriuretic Peptides</a><script data-card-contents-for-ri="116889" type="text/json">{"id":116889,"name":"Natriuretic Peptides","url":"https://www.academia.edu/Documents/in/Natriuretic_Peptides?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21651075]'), work: {"id":21651075,"title":"Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice","created_at":"2016-02-07T04:05:34.927-08:00","url":"https://www.academia.edu/21651075/Heart_specific_up_regulation_of_genes_for_B_type_and_C_type_natriuretic_peptide_receptors_in_diabetic_mice?f_ri=99234","dom_id":"work_21651075","summary":null,"downloadable_attachments":[{"id":42292249,"asset_id":21651075,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32490701,"first_name":"C.","last_name":"Christoffersen","domain_name":"independent","page_name":"ChristoffersenC","display_name":"C. 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Therefore, reconstructing the history of their association is of evolutionary, ecological, and conservation significance. Here, time-calibrated Bayesian phylogenies of Euastacus species and their temnocephalans (Temnohaswellia and Temnosewellia) indicate near-synchronous diversifications from the Cretaceous. Statistically significant cophylogeny correlations between associated clades suggest linked evolutionary histories. However, there is a stronger signal of codivergence and greater host specificity in Temnosewellia, which co-occurs with Euastacus across its range. Phylogeography and analyses of evolutionary distinctiveness (ED) suggest that regional differences in the impact of climate warming and drying had major effects both on crayfish...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58007549" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ff2e142a83f6348786eb5fcdccd55b76" rel="nofollow" data-download="{&quot;attachment_id&quot;:72631713,&quot;asset_id&quot;:58007549,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72631713/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="81741437" href="https://independent.academia.edu/LesterCannon">Lester Cannon</a><script data-card-contents-for-user="81741437" type="text/json">{"id":81741437,"first_name":"Lester","last_name":"Cannon","domain_name":"independent","page_name":"LesterCannon","display_name":"Lester Cannon","profile_url":"https://independent.academia.edu/LesterCannon?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_58007549 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58007549"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58007549, container: ".js-paper-rank-work_58007549", }); 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Therefore, reconstructing the history of their association is of evolutionary, ecological, and conservation significance. Here, time-calibrated Bayesian phylogenies of Euastacus species and their temnocephalans (Temnohaswellia and Temnosewellia) indicate near-synchronous diversifications from the Cretaceous. Statistically significant cophylogeny correlations between associated clades suggest linked evolutionary histories. However, there is a stronger signal of codivergence and greater host specificity in Temnosewellia, which co-occurs with Euastacus across its range. Phylogeography and analyses of evolutionary distinctiveness (ED) suggest that regional differences in the impact of climate warming and drying had major effects both on crayfish...","downloadable_attachments":[{"id":72631713,"asset_id":58007549,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":81741437,"first_name":"Lester","last_name":"Cannon","domain_name":"independent","page_name":"LesterCannon","display_name":"Lester Cannon","profile_url":"https://independent.academia.edu/LesterCannon?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2467,"name":"Conservation 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11-dehydrothromboxane B2 in the cynomolgus monkey</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47501020" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dee2e2cc9ddcc161502b8c44eb2fd29e" rel="nofollow" data-download="{&quot;attachment_id&quot;:66561517,&quot;asset_id&quot;:47501020,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button 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data-work_id="59065618" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/59065618/Prodrugs_design_and_clinical_applications">Prodrugs: design and clinical applications</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/59065618" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e790e641f8d7a43153a3d446952e2d6a" rel="nofollow" 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href="https://www.academia.edu/Documents/in/Nature">Nature</a>,&nbsp;<script data-card-contents-for-ri="33319" type="text/json">{"id":33319,"name":"Nature","url":"https://www.academia.edu/Documents/in/Nature?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>,&nbsp;<script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64461" href="https://www.academia.edu/Documents/in/Prodrugs">Prodrugs</a><script data-card-contents-for-ri="64461" type="text/json">{"id":64461,"name":"Prodrugs","url":"https://www.academia.edu/Documents/in/Prodrugs?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: 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Group","url":"https://www.academia.edu/Documents/in/Functional_Group?f_ri=99234"},{"id":1136192,"name":"Biological Availability","url":"https://www.academia.edu/Documents/in/Biological_Availability?f_ri=99234"},{"id":1188229,"name":"Parenteral Nutrition","url":"https://www.academia.edu/Documents/in/Parenteral_Nutrition?f_ri=99234"},{"id":1275886,"name":"Clinical Application","url":"https://www.academia.edu/Documents/in/Clinical_Application?f_ri=99234"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24101187" data-work_id="24101187" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24101187/In_Vivo_Inhibition_of_Anti_Hepatitis_B_Virus_Core_Antigen_HBcAg_Immunoglobulin_G_Production_by_HBcAg_Specific_CD4_Th1_Type_T_Cell_Clones_in_a_hu_PBL_NOD_SCID_Mouse_Model">In Vivo Inhibition of Anti-Hepatitis B Virus Core Antigen (HBcAg) Immunoglobulin G Production by HBcAg-Specific CD4+ Th1-Type T-Cell Clones in a hu-PBL-NOD/SCID Mouse Model</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24101187" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cec5be96001f94d0e42acd47a969db07" rel="nofollow" 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href="https://independent.academia.edu/IsabelleDesombere">Isabelle Desombere</a><script data-card-contents-for-user="33770610" type="text/json">{"id":33770610,"first_name":"Isabelle","last_name":"Desombere","domain_name":"independent","page_name":"IsabelleDesombere","display_name":"Isabelle Desombere","profile_url":"https://independent.academia.edu/IsabelleDesombere?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24101187 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24101187"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24101187, container: ".js-paper-rank-work_24101187", }); });</script></li><li class="js-percentile-work_24101187 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x 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$(".js-view-count-work_24101187").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24101187").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24101187"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">16</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2702" href="https://www.academia.edu/Documents/in/Immune_response">Immune response</a>,&nbsp;<script data-card-contents-for-ri="2702" type="text/json">{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8089" href="https://www.academia.edu/Documents/in/Virology">Virology</a>,&nbsp;<script data-card-contents-for-ri="8089" type="text/json">{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>,&nbsp;<script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="63331" href="https://www.academia.edu/Documents/in/Hepatitis_B">Hepatitis B</a><script data-card-contents-for-ri="63331" type="text/json">{"id":63331,"name":"Hepatitis B","url":"https://www.academia.edu/Documents/in/Hepatitis_B?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24101187]'), work: {"id":24101187,"title":"In Vivo Inhibition of Anti-Hepatitis B Virus Core Antigen (HBcAg) Immunoglobulin G Production by HBcAg-Specific CD4+ Th1-Type T-Cell Clones in a hu-PBL-NOD/SCID Mouse Model","created_at":"2016-04-06T00:48:21.571-07:00","url":"https://www.academia.edu/24101187/In_Vivo_Inhibition_of_Anti_Hepatitis_B_Virus_Core_Antigen_HBcAg_Immunoglobulin_G_Production_by_HBcAg_Specific_CD4_Th1_Type_T_Cell_Clones_in_a_hu_PBL_NOD_SCID_Mouse_Model?f_ri=99234","dom_id":"work_24101187","summary":null,"downloadable_attachments":[{"id":44465449,"asset_id":24101187,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33770610,"first_name":"Isabelle","last_name":"Desombere","domain_name":"independent","page_name":"IsabelleDesombere","display_name":"Isabelle Desombere","profile_url":"https://independent.academia.edu/IsabelleDesombere?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=99234","nofollow":false},{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology?f_ri=99234","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=99234","nofollow":false},{"id":63331,"name":"Hepatitis B","url":"https://www.academia.edu/Documents/in/Hepatitis_B?f_ri=99234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=99234"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=99234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype?f_ri=99234"},{"id":315624,"name":"Epstein-Barr virus","url":"https://www.academia.edu/Documents/in/Epstein-Barr_virus?f_ri=99234"},{"id":323415,"name":"Mouse Model","url":"https://www.academia.edu/Documents/in/Mouse_Model?f_ri=99234"},{"id":816379,"name":"Virus infection","url":"https://www.academia.edu/Documents/in/Virus_infection?f_ri=99234"},{"id":825565,"name":"Hepatitis B virus","url":"https://www.academia.edu/Documents/in/Hepatitis_B_virus?f_ri=99234"},{"id":855510,"name":"Liver Disease","url":"https://www.academia.edu/Documents/in/Liver_Disease?f_ri=99234"},{"id":1180667,"name":"Optimality Condition","url":"https://www.academia.edu/Documents/in/Optimality_Condition?f_ri=99234"},{"id":1255525,"name":"Chronic Liver Disease","url":"https://www.academia.edu/Documents/in/Chronic_Liver_Disease?f_ri=99234"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_67560764" data-work_id="67560764" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/67560764/Reconceiving_autoimmunity_An_overview">Reconceiving autoimmunity: An overview</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Three interconnected positions are advocated: (1) although serving as a useful model, the immune self does not exist as such; (2) instead of a self/nonself demarcation, the immune system &amp;#39;sees&amp;#39; itself, i.e., it does not ignore the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_67560764" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Three interconnected positions are advocated: (1) although serving as a useful model, the immune self does not exist as such; (2) instead of a self/nonself demarcation, the immune system &amp;#39;sees&amp;#39; itself, i.e., it does not ignore the &amp;#39;self&amp;#39; or attack the &amp;#39;other;&amp;#39; but exhibits a spectrum of responses, which when viewed from outside the system appear as discrimination of &amp;#39;self&amp;#39; and &amp;#39;nonself&amp;#39; based on certain criteria of reactivity. When immune reactions are conceived in terms of normal physiology and open exchange with the environment, where borders dividing host and foreign are elusive and changing, host defense is only part of the immune system&amp;#39;s functions, which actually comprise two basic tasks: protection, i.e., to preserve host integrity, and maintenance of organismic identity. And thus (3) if the spectrum of immunity is enlarged, differentiating low reactive &amp;#39;autoimmune&amp;#39; reactions from activated immune responses against the &amp;#39;...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/67560764" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a2c98b2391d78b677729d4265c72a523" rel="nofollow" data-download="{&quot;attachment_id&quot;:78331518,&quot;asset_id&quot;:67560764,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78331518/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8781609" href="https://bu.academia.edu/AlfredTauber">Alfred Tauber</a><script data-card-contents-for-user="8781609" type="text/json">{"id":8781609,"first_name":"Alfred","last_name":"Tauber","domain_name":"bu","page_name":"AlfredTauber","display_name":"Alfred Tauber","profile_url":"https://bu.academia.edu/AlfredTauber?f_ri=99234","photo":"https://0.academia-photos.com/8781609/3222050/3791806/s65_alfred.tauber.jpg"}</script></span></span></li><li class="js-paper-rank-work_67560764 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="67560764"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 67560764, container: ".js-paper-rank-work_67560764", }); 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$(".js-view-count[data-work-id=67560764]").text(description); $(".js-view-count-work_67560764").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_67560764").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="67560764"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">13</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7043" href="https://www.academia.edu/Documents/in/Symbiosis">Symbiosis</a>,&nbsp;<script data-card-contents-for-ri="7043" type="text/json">{"id":7043,"name":"Symbiosis","url":"https://www.academia.edu/Documents/in/Symbiosis?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a>,&nbsp;<script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9846" href="https://www.academia.edu/Documents/in/Ecology">Ecology</a>,&nbsp;<script data-card-contents-for-ri="9846" type="text/json">{"id":9846,"name":"Ecology","url":"https://www.academia.edu/Documents/in/Ecology?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12320" href="https://www.academia.edu/Documents/in/Autoimmunity">Autoimmunity</a><script data-card-contents-for-ri="12320" type="text/json">{"id":12320,"name":"Autoimmunity","url":"https://www.academia.edu/Documents/in/Autoimmunity?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=67560764]'), work: {"id":67560764,"title":"Reconceiving autoimmunity: An overview","created_at":"2022-01-07T13:45:30.710-08:00","url":"https://www.academia.edu/67560764/Reconceiving_autoimmunity_An_overview?f_ri=99234","dom_id":"work_67560764","summary":"Three interconnected positions are advocated: (1) although serving as a useful model, the immune self does not exist as such; (2) instead of a self/nonself demarcation, the immune system \u0026#39;sees\u0026#39; itself, i.e., it does not ignore the \u0026#39;self\u0026#39; or attack the \u0026#39;other;\u0026#39; but exhibits a spectrum of responses, which when viewed from outside the system appear as discrimination of \u0026#39;self\u0026#39; and \u0026#39;nonself\u0026#39; based on certain criteria of reactivity. When immune reactions are conceived in terms of normal physiology and open exchange with the environment, where borders dividing host and foreign are elusive and changing, host defense is only part of the immune system\u0026#39;s functions, which actually comprise two basic tasks: protection, i.e., to preserve host integrity, and maintenance of organismic identity. 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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21350563/Split_sample_comparison_of_directional_and_liquid_nitrogen_vapour_freezing_method_on_post_thaw_semen_quality_in_white_rhinoceroses_Ceratotherium_simum_simum_and_Ceratotherium_simum_cottoni_">Split-sample comparison of directional and liquid nitrogen vapour freezing method on post-thaw semen quality in white rhinoceroses (Ceratotherium simum simum and Ceratotherium simum cottoni)</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21350563" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" 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itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42440253" href="https://independent.academia.edu/CatherineReid2">Catherine Reid</a><script data-card-contents-for-user="42440253" type="text/json">{"id":42440253,"first_name":"Catherine","last_name":"Reid","domain_name":"independent","page_name":"CatherineReid2","display_name":"Catherine Reid","profile_url":"https://independent.academia.edu/CatherineReid2?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text">&nbsp;and&nbsp;<span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-21350563">+1</span><div class="hidden js-additional-users-21350563"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/FrankGoeritz">Frank Goeritz</a></span></div></div></span><script>(function(){ 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type="text/json">{"id":19295,"name":"Cryopreservation","url":"https://www.academia.edu/Documents/in/Cryopreservation?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23979" href="https://www.academia.edu/Documents/in/Endangered_Species">Endangered Species</a>,&nbsp;<script data-card-contents-for-ri="23979" type="text/json">{"id":23979,"name":"Endangered Species","url":"https://www.academia.edu/Documents/in/Endangered_Species?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="43820" href="https://www.academia.edu/Documents/in/Theriogenology">Theriogenology</a><script data-card-contents-for-ri="43820" type="text/json">{"id":43820,"name":"Theriogenology","url":"https://www.academia.edu/Documents/in/Theriogenology?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21350563]'), work: {"id":21350563,"title":"Split-sample comparison of directional and liquid nitrogen vapour freezing method on post-thaw semen quality in white rhinoceroses (Ceratotherium simum simum and Ceratotherium simum cottoni)","created_at":"2016-01-31T18:54:18.756-08:00","url":"https://www.academia.edu/21350563/Split_sample_comparison_of_directional_and_liquid_nitrogen_vapour_freezing_method_on_post_thaw_semen_quality_in_white_rhinoceroses_Ceratotherium_simum_simum_and_Ceratotherium_simum_cottoni_?f_ri=99234","dom_id":"work_21350563","summary":null,"downloadable_attachments":[{"id":41828431,"asset_id":21350563,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42440253,"first_name":"Catherine","last_name":"Reid","domain_name":"independent","page_name":"CatherineReid2","display_name":"Catherine 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Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=99234"},{"id":77509,"name":"Perissodactyla","url":"https://www.academia.edu/Documents/in/Perissodactyla?f_ri=99234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=99234"},{"id":151091,"name":"Nitrogen","url":"https://www.academia.edu/Documents/in/Nitrogen?f_ri=99234"},{"id":151662,"name":"Additives","url":"https://www.academia.edu/Documents/in/Additives?f_ri=99234"},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=99234"},{"id":277066,"name":"Head","url":"https://www.academia.edu/Documents/in/Head?f_ri=99234"},{"id":945101,"name":"Liquid Nitrogen","url":"https://www.academia.edu/Documents/in/Liquid_Nitrogen?f_ri=99234"},{"id":1029221,"name":"Freezing","url":"https://www.academia.edu/Documents/in/Freezing?f_ri=99234"},{"id":1043331,"name":"Semen Preservation","url":"https://www.academia.edu/Documents/in/Semen_Preservation?f_ri=99234"},{"id":1221081,"name":"Semen Quality","url":"https://www.academia.edu/Documents/in/Semen_Quality?f_ri=99234"},{"id":1223743,"name":"Sperm Quality","url":"https://www.academia.edu/Documents/in/Sperm_Quality?f_ri=99234"},{"id":1242344,"name":"Plasma Membrane","url":"https://www.academia.edu/Documents/in/Plasma_Membrane?f_ri=99234"},{"id":1759332,"name":"Sexual reproduction","url":"https://www.academia.edu/Documents/in/Sexual_reproduction?f_ri=99234"},{"id":2295414,"name":"Thermal Gradient","url":"https://www.academia.edu/Documents/in/Thermal_Gradient?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14424536 coauthored" data-work_id="14424536" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14424536/Crystallization_scale_preparation_of_a_stable_GPCR_signaling_complex_between_constitutively_active_rhodopsin_and_G_protein">Crystallization scale preparation of a stable GPCR signaling complex between constitutively active rhodopsin and G-protein</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The activation of the G-protein transducin (Gt) by rhodopsin (Rho) has been intensively studied for several decades. It is the best understood example of GPCR activation mechanism and serves as a template for other GPCRs. The structure of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14424536" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The activation of the G-protein transducin (Gt) by rhodopsin (Rho) has been intensively studied for several decades. It is the best understood example of GPCR activation mechanism and serves as a template for other GPCRs. The structure of the Rho/G protein complex, which is transiently formed during the signaling reaction, is of particular interest. It can help understanding the molecular details of how retinal isomerization leads to the G protein activation, as well as shed some light on how GPCR recognizes its cognate G protein. The native Rho/Gt complex isolated from bovine retina suffers from low stability and loss of the retinal ligand. Recently, we reported that constitutively active mutant of rhodopsin E113Q forms a Rho/Gt complex that is stable in detergent solution. Here, we introduce methods for a large scale preparation of the complex formed by the thermo-stabilized and constitutively active rhodopsin mutant N2C/M257Y/D282C(RhoM257Y) and the native Gt purified from bovine...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14424536" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5d061468a027f7985d3e91f8b859ca25" rel="nofollow" data-download="{&quot;attachment_id&quot;:44157456,&quot;asset_id&quot;:14424536,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44157456/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33365072" href="https://psi-ch.academia.edu/GebhardSchertler">Gebhard F X Schertler</a><script data-card-contents-for-user="33365072" type="text/json">{"id":33365072,"first_name":"Gebhard","last_name":"Schertler","domain_name":"psi-ch","page_name":"GebhardSchertler","display_name":"Gebhard F X Schertler","profile_url":"https://psi-ch.academia.edu/GebhardSchertler?f_ri=99234","photo":"https://0.academia-photos.com/33365072/12447282/13852903/s65_gebhard.schertler.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text">&nbsp;and&nbsp;<span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-14424536">+3</span><div class="hidden js-additional-users-14424536"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/DmitryVeprintsev">Dmitry Veprintsev</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://stanford.academia.edu/ShojiMaeda">Shoji Maeda</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://unibasel.academia.edu/MichaelHennig">Michael Hennig</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-14424536'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-14424536').html(); 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Here, we introduce methods for a large scale preparation of the complex formed by the thermo-stabilized and constitutively active rhodopsin mutant N2C/M257Y/D282C(RhoM257Y) and the native Gt purified from bovine...","downloadable_attachments":[{"id":44157456,"asset_id":14424536,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33365072,"first_name":"Gebhard","last_name":"Schertler","domain_name":"psi-ch","page_name":"GebhardSchertler","display_name":"Gebhard F X Schertler","profile_url":"https://psi-ch.academia.edu/GebhardSchertler?f_ri=99234","photo":"https://0.academia-photos.com/33365072/12447282/13852903/s65_gebhard.schertler.jpg"},{"id":33412293,"first_name":"Dmitry","last_name":"Veprintsev","domain_name":"independent","page_name":"DmitryVeprintsev","display_name":"Dmitry 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30306681/A_Possible_Role_of_the_Thalamus_in_Some_Cases_of_Sudden_Unexpected_Death_in_Epilepsy">A Possible Role of the Thalamus in Some Cases of Sudden Unexpected Death in Epilepsy</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30306681" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="22c957bc50dc0fac208590b7d6e86080" rel="nofollow" data-download="{&quot;attachment_id&quot;:50764315,&quot;asset_id&quot;:30306681,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50764315/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="57682210" href="https://unifesp.academia.edu/RicardoMarioArida">Ricardo Mario Arida</a><script data-card-contents-for-user="57682210" type="text/json">{"id":57682210,"first_name":"Ricardo Mario","last_name":"Arida","domain_name":"unifesp","page_name":"RicardoMarioArida","display_name":"Ricardo Mario Arida","profile_url":"https://unifesp.academia.edu/RicardoMarioArida?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30306681 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30306681"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30306681, container: ".js-paper-rank-work_30306681", }); });</script></li><li class="js-percentile-work_30306681 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26466216" data-work_id="26466216" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26466216/The_systemic_milieu_as_a_mediator_of_dietary_influence_on_stem_cell_function_during_ageing">The systemic milieu as a mediator of dietary influence on stem cell function during ageing</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26466216" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/6177129/Effects_of_microwaves_900_MHz_on_the_cochlear_receptor_exposure_systems_and_preliminary_results">Effects of microwaves (900 MHz) on the cochlear receptor: exposure systems and preliminary results</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The purpose of this paper is to present the experimental device and the work in progress performed in search for objective organic correlation of damage to hearing, examining possible acoustic otofunctional effects on the cochlear... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6177129" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The purpose of this paper is to present the experimental device and the work in progress performed in search for objective organic correlation of damage to hearing, examining possible acoustic otofunctional effects on the cochlear epithelium of the rat due to exposure to microwaves (900 MHz). Two experiments using male Sprague-Dawley rats were carried out with a far-field exposure in a cubic chamber. No statistically significant evidence was obtained at both specific absorption rate (SAR) values. The exposure system and the diagnostic apparatus are extremely useful to investigate a potential effect on the auditory system: however, with the parameters applied in these experiments, no evidence was observed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6177129" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="530cceebc2a15c891f82c8ce1a48cb0d" rel="nofollow" data-download="{&quot;attachment_id&quot;:48982557,&quot;asset_id&quot;:6177129,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48982557/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="9413374" href="https://independent.academia.edu/MartaCristal">Marta Cristal</a><script data-card-contents-for-user="9413374" type="text/json">{"id":9413374,"first_name":"Marta","last_name":"Cristal","domain_name":"independent","page_name":"MartaCristal","display_name":"Marta Cristal","profile_url":"https://independent.academia.edu/MartaCristal?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_6177129 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6177129"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6177129, container: ".js-paper-rank-work_6177129", }); 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href="https://www.academia.edu/6082696/Acute_Hemodynamic_Efficacy_of_a_32_ml_Subcutaneous_Counterpulsation_Device_in_a_Calf_Model_of_Diminished_Cardiac_Function">Acute Hemodynamic Efficacy of a 32-ml Subcutaneous Counterpulsation Device in a Calf Model of Diminished Cardiac Function</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6082696" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2203739041b3af02a509040cae09ce14" rel="nofollow" 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href="https://www.academia.edu/32714400/Protection_against_Radiation_Induced_Bone_Marrow_and_Intestinal_Injuries_by_Cordyceps_sinensis_a_Chinese_Herbal_Medicine">Protection against Radiation-Induced Bone Marrow and Intestinal Injuries by Cordyceps sinensis, a Chinese Herbal Medicine</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32714400" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4d4d808fe9d6f4e832ff465cc10ea7cf" rel="nofollow" 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$('*[data-has-card-for-ri-list=32714400]'), work: {"id":32714400,"title":"Protection against Radiation-Induced Bone Marrow and Intestinal Injuries by Cordyceps sinensis, a Chinese Herbal Medicine","created_at":"2017-04-29T02:18:22.060-07:00","url":"https://www.academia.edu/32714400/Protection_against_Radiation_Induced_Bone_Marrow_and_Intestinal_Injuries_by_Cordyceps_sinensis_a_Chinese_Herbal_Medicine?f_ri=99234","dom_id":"work_32714400","summary":null,"downloadable_attachments":[{"id":52875679,"asset_id":32714400,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":63635855,"first_name":"Chi-Shiun","last_name":"Chiang","domain_name":"independent","page_name":"ChiShiunChiang","display_name":"Chi-Shiun 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Failure","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Failure?f_ri=99234"},{"id":1979328,"name":"Total body irradiation","url":"https://www.academia.edu/Documents/in/Total_body_irradiation?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16800989" data-work_id="16800989" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16800989/Topical_and_mucosal_liposomes_for_vaccine_delivery">Topical and mucosal liposomes for vaccine delivery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Mucosal (and in minor extent transcutanous) stimulation can induce local or distant mucosa secretory IgA. Liposomes and other vesicles as mucosal and transcutaneous adjuvants are attractive alternatives to parenteral vaccination.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16800989" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Mucosal (and in minor extent transcutanous) stimulation can induce local or distant mucosa secretory IgA. Liposomes and other vesicles as mucosal and transcutaneous adjuvants are attractive alternatives to parenteral vaccination. Liposomes can be massively produced under good manufacturing practices and stored for long periods, at high antigen/vesicle mass ratios. However, their uptake by antigen-presenting cells (APC) at the inductive sites remains as a major challenge. As neurotoxicity is a major concern in intranasal delivery, complexes between archaeosomes and calcium as well as cationic liposomes complexed with plasmids encoding for antigenic proteins could safely elicit secretory and systemic antigen-specific immune responses. Oral bilosomes generate intense immune responses that remain to be tested against challenge, but the admixing with toxins or derivatives is mandatory to reduce the amount of antigen. Most of the current experimental designs, however, underestimate the mu...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16800989" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2045af17158cd3a65abfe8885eaefcab" rel="nofollow" data-download="{&quot;attachment_id&quot;:39190188,&quot;asset_id&quot;:16800989,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39190188/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="10555545" href="https://independent.academia.edu/mariajosemorilla">maria jose morilla</a><script data-card-contents-for-user="10555545" type="text/json">{"id":10555545,"first_name":"maria jose","last_name":"morilla","domain_name":"independent","page_name":"mariajosemorilla","display_name":"maria jose morilla","profile_url":"https://independent.academia.edu/mariajosemorilla?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16800989 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16800989"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16800989, container: ".js-paper-rank-work_16800989", }); 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$(".js-view-count[data-work-id=16800989]").text(description); $(".js-view-count-work_16800989").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16800989").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16800989"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">13</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4365" href="https://www.academia.edu/Documents/in/Vaccines">Vaccines</a>,&nbsp;<script data-card-contents-for-ri="4365" type="text/json">{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8501" href="https://www.academia.edu/Documents/in/Phospholipids">Phospholipids</a>,&nbsp;<script data-card-contents-for-ri="8501" type="text/json">{"id":8501,"name":"Phospholipids","url":"https://www.academia.edu/Documents/in/Phospholipids?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9334" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>,&nbsp;<script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16800989]'), work: {"id":16800989,"title":"Topical and mucosal liposomes for vaccine delivery","created_at":"2015-10-14T16:14:17.535-07:00","url":"https://www.academia.edu/16800989/Topical_and_mucosal_liposomes_for_vaccine_delivery?f_ri=99234","dom_id":"work_16800989","summary":"Mucosal (and in minor extent transcutanous) stimulation can induce local or distant mucosa secretory IgA. Liposomes and other vesicles as mucosal and transcutaneous adjuvants are attractive alternatives to parenteral vaccination. Liposomes can be massively produced under good manufacturing practices and stored for long periods, at high antigen/vesicle mass ratios. However, their uptake by antigen-presenting cells (APC) at the inductive sites remains as a major challenge. As neurotoxicity is a major concern in intranasal delivery, complexes between archaeosomes and calcium as well as cationic liposomes complexed with plasmids encoding for antigenic proteins could safely elicit secretory and systemic antigen-specific immune responses. Oral bilosomes generate intense immune responses that remain to be tested against challenge, but the admixing with toxins or derivatives is mandatory to reduce the amount of antigen. Most of the current experimental designs, however, underestimate the mu...","downloadable_attachments":[{"id":39190188,"asset_id":16800989,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":10555545,"first_name":"maria jose","last_name":"morilla","domain_name":"independent","page_name":"mariajosemorilla","display_name":"maria jose morilla","profile_url":"https://independent.academia.edu/mariajosemorilla?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines?f_ri=99234","nofollow":false},{"id":8501,"name":"Phospholipids","url":"https://www.academia.edu/Documents/in/Phospholipids?f_ri=99234","nofollow":false},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=99234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=99234","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=99234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234"},{"id":147066,"name":"Liposomes","url":"https://www.academia.edu/Documents/in/Liposomes?f_ri=99234"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems?f_ri=99234"},{"id":190363,"name":"Plasmids","url":"https://www.academia.edu/Documents/in/Plasmids?f_ri=99234"},{"id":209510,"name":"Epidermis","url":"https://www.academia.edu/Documents/in/Epidermis?f_ri=99234"},{"id":375078,"name":"Topical Drug Administration","url":"https://www.academia.edu/Documents/in/Topical_Drug_Administration?f_ri=99234"},{"id":648676,"name":"Mucus","url":"https://www.academia.edu/Documents/in/Mucus?f_ri=99234"},{"id":954248,"name":"Detergents","url":"https://www.academia.edu/Documents/in/Detergents?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_32635794" data-work_id="32635794" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/32635794/Epigenetics_and_its_role_in_male_infertility">Epigenetics and its role in male infertility</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32635794" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="688e62ea6833868d6066e93b41f045c3" rel="nofollow" data-download="{&quot;attachment_id&quot;:52806149,&quot;asset_id&quot;:32635794,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52806149/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="63327258" href="https://independent.academia.edu/manojkumar1991">manoj kumar</a><script data-card-contents-for-user="63327258" type="text/json">{"id":63327258,"first_name":"manoj","last_name":"kumar","domain_name":"independent","page_name":"manojkumar1991","display_name":"manoj kumar","profile_url":"https://independent.academia.edu/manojkumar1991?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_32635794 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="32635794"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 32635794, container: ".js-paper-rank-work_32635794", }); });</script></li><li class="js-percentile-work_32635794 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 32635794; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_32635794"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_32635794 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="32635794"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 32635794; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=32635794]").text(description); $(".js-view-count-work_32635794").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_32635794").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="32635794"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">9</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>,&nbsp;<script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>,&nbsp;<script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="75577" href="https://www.academia.edu/Documents/in/Spermatogenesis">Spermatogenesis</a>,&nbsp;<script data-card-contents-for-ri="75577" type="text/json">{"id":75577,"name":"Spermatogenesis","url":"https://www.academia.edu/Documents/in/Spermatogenesis?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a><script data-card-contents-for-ri="99234" type="text/json">{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=32635794]'), work: {"id":32635794,"title":"Epigenetics and its role in male infertility","created_at":"2017-04-25T00:32:10.448-07:00","url":"https://www.academia.edu/32635794/Epigenetics_and_its_role_in_male_infertility?f_ri=99234","dom_id":"work_32635794","summary":null,"downloadable_attachments":[{"id":52806149,"asset_id":32635794,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":63327258,"first_name":"manoj","last_name":"kumar","domain_name":"independent","page_name":"manojkumar1991","display_name":"manoj kumar","profile_url":"https://independent.academia.edu/manojkumar1991?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=99234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=99234","nofollow":false},{"id":75577,"name":"Spermatogenesis","url":"https://www.academia.edu/Documents/in/Spermatogenesis?f_ri=99234","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234","nofollow":false},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=99234"},{"id":178928,"name":"Male Infertility","url":"https://www.academia.edu/Documents/in/Male_Infertility?f_ri=99234"},{"id":352300,"name":"Embryonic Development","url":"https://www.academia.edu/Documents/in/Embryonic_Development?f_ri=99234"},{"id":862371,"name":"Spermatozoa","url":"https://www.academia.edu/Documents/in/Spermatozoa?f_ri=99234"},{"id":2562986,"name":"Oligospermia","url":"https://www.academia.edu/Documents/in/Oligospermia?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16100688 coauthored" data-work_id="16100688" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16100688/Exercise_and_time_dependent_benefits_to_learning_and_memory">Exercise and time-dependent benefits to learning and memory</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">While it is well established that exercise can improve cognitive performance, it is unclear how long these benefits endure after exercise has ended. Accordingly, the effects of voluntary exercise on cognitive function and brain-derived... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16100688" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">While it is well established that exercise can improve cognitive performance, it is unclear how long these benefits endure after exercise has ended. Accordingly, the effects of voluntary exercise on cognitive function and brain-derived neurotrophic factor (BDNF) protein levels, a major player in the mechanisms governing the dynamics of memory formation and storage, were assessed immediately after a 3-week running period, or after a 1-week or 2-week delay following the exercise period. All exercised mice showed improved performance on the radial arm water maze relative to sedentary animals. Unexpectedly, fastest acquisition (fewest errors and shortest latency) occurred in animals trained following a 1-week delay, while best memory performance in the probe trial was observed in those trained immediately after the exercise period. Assessment of the time course of hippocampal BDNF availability following exercise revealed significant elevations of BDNF immediately after the exercise peri...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16100688" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c673a8e25ca8aa3fa163401986293e51" rel="nofollow" data-download="{&quot;attachment_id&quot;:42748779,&quot;asset_id&quot;:16100688,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42748779/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35219708" href="https://independent.academia.edu/NCastello">N. Castello</a><script data-card-contents-for-user="35219708" type="text/json">{"id":35219708,"first_name":"N.","last_name":"Castello","domain_name":"independent","page_name":"NCastello","display_name":"N. Castello","profile_url":"https://independent.academia.edu/NCastello?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text">&nbsp;and&nbsp;<span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16100688">+1</span><div class="hidden js-additional-users-16100688"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/NBerchtold">N. Berchtold</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16100688'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16100688').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_16100688 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16100688"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16100688, container: ".js-paper-rank-work_16100688", }); });</script></li><li class="js-percentile-work_16100688 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16100688; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16100688"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16100688 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16100688"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16100688; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16100688]").text(description); $(".js-view-count-work_16100688").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16100688").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16100688"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">25</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="161" href="https://www.academia.edu/Documents/in/Neuroscience">Neuroscience</a>,&nbsp;<script data-card-contents-for-ri="161" type="text/json">{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="221" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>,&nbsp;<script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9112" href="https://www.academia.edu/Documents/in/Physical_Activity">Physical Activity</a>,&nbsp;<script data-card-contents-for-ri="9112" type="text/json">{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="43774" href="https://www.academia.edu/Documents/in/Learning">Learning</a><script data-card-contents-for-ri="43774" type="text/json">{"id":43774,"name":"Learning","url":"https://www.academia.edu/Documents/in/Learning?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16100688]'), work: {"id":16100688,"title":"Exercise and time-dependent benefits to learning and memory","created_at":"2015-09-23T14:11:12.979-07:00","url":"https://www.academia.edu/16100688/Exercise_and_time_dependent_benefits_to_learning_and_memory?f_ri=99234","dom_id":"work_16100688","summary":"While it is well established that exercise can improve cognitive performance, it is unclear how long these benefits endure after exercise has ended. Accordingly, the effects of voluntary exercise on cognitive function and brain-derived neurotrophic factor (BDNF) protein levels, a major player in the mechanisms governing the dynamics of memory formation and storage, were assessed immediately after a 3-week running period, or after a 1-week or 2-week delay following the exercise period. All exercised mice showed improved performance on the radial arm water maze relative to sedentary animals. Unexpectedly, fastest acquisition (fewest errors and shortest latency) occurred in animals trained following a 1-week delay, while best memory performance in the probe trial was observed in those trained immediately after the exercise period. Assessment of the time course of hippocampal BDNF availability following exercise revealed significant elevations of BDNF immediately after the exercise peri...","downloadable_attachments":[{"id":42748779,"asset_id":16100688,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35219708,"first_name":"N.","last_name":"Castello","domain_name":"independent","page_name":"NCastello","display_name":"N. Castello","profile_url":"https://independent.academia.edu/NCastello?f_ri=99234","photo":"/images/s65_no_pic.png"},{"id":60799202,"first_name":"N.","last_name":"Berchtold","domain_name":"independent","page_name":"NBerchtold","display_name":"N. Berchtold","profile_url":"https://independent.academia.edu/NBerchtold?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience?f_ri=99234","nofollow":false},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=99234","nofollow":false},{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=99234","nofollow":false},{"id":43774,"name":"Learning","url":"https://www.academia.edu/Documents/in/Learning?f_ri=99234","nofollow":false},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=99234"},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=99234"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=99234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234"},{"id":100966,"name":"Brain Plasticity","url":"https://www.academia.edu/Documents/in/Brain_Plasticity?f_ri=99234"},{"id":105608,"name":"Spatial","url":"https://www.academia.edu/Documents/in/Spatial?f_ri=99234"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=99234"},{"id":132020,"name":"Neuronal Plasticity","url":"https://www.academia.edu/Documents/in/Neuronal_Plasticity?f_ri=99234"},{"id":177251,"name":"CREB","url":"https://www.academia.edu/Documents/in/CREB?f_ri=99234"},{"id":233770,"name":"Cognitive Performance","url":"https://www.academia.edu/Documents/in/Cognitive_Performance?f_ri=99234"},{"id":298943,"name":"TrkB","url":"https://www.academia.edu/Documents/in/TrkB?f_ri=99234"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=99234"},{"id":426260,"name":"Calmodulin","url":"https://www.academia.edu/Documents/in/Calmodulin?f_ri=99234"},{"id":441653,"name":"Cognitive Function","url":"https://www.academia.edu/Documents/in/Cognitive_Function?f_ri=99234"},{"id":595079,"name":"MAPK","url":"https://www.academia.edu/Documents/in/MAPK?f_ri=99234"},{"id":974411,"name":"Memory Disorders","url":"https://www.academia.edu/Documents/in/Memory_Disorders?f_ri=99234"},{"id":1169505,"name":"Maze Learning","url":"https://www.academia.edu/Documents/in/Maze_Learning?f_ri=99234"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=99234"},{"id":1315979,"name":"Time Course","url":"https://www.academia.edu/Documents/in/Time_Course?f_ri=99234"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=99234"},{"id":1916141,"name":"Water maze","url":"https://www.academia.edu/Documents/in/Water_maze?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11180030" data-work_id="11180030" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11180030/Non_invasive_vaccine_delivery_in_transfersomes_niosomes_and_liposomes_a_comparative_study">Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: a comparative study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Non-invasive vaccine delivery is a top priority for public health agencies because conventional immunization practices are unsafe and associated with numerous limitations. Recently, the skin has emerged as a potential alternative route... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11180030" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Non-invasive vaccine delivery is a top priority for public health agencies because conventional immunization practices are unsafe and associated with numerous limitations. Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. Topical immunization (TI), introduction of antigen through topical application onto the intact skin, has many practical merits compared to injectable routes of administration. One of the possibilities for increasing the penetration of bioactives through the skin is the use of vesicular systems. Specially designed lipid vesicles are attracting intense attention and can be used for non-invasive antigen delivery. In the present study, elastic vesicle transfersomes, non-ionic surfactant vesicles (niosomes) and liposomes were used to study their relative potential in non-invasive delivery of tetanus toxoid (TT). Transfersomes, niosomes and liposomes were prepared and characterized for shape, size and entrapment efficiency. These vesicles were extruded through polycarbonate filter (50-nm pore size) to assess the elasticity of the vesicles. The immune stimulating activity of transfersomes, niosomes and liposomes were studied by measuring the serum anti-TT IgG titre following topical immunization. The immune response elicited by topical immunization was compared with that elicited by same dose of alum-adsorbed tetanus toxoid (AATT) given intramuscularly. The results indicate that optimal formulations of transfersomes, niosomes and liposomes could entrap 72.7 ± 3.4, 42.5 ± 2.4 and 41.3 ± 2.2% of antigen and their elasticity values were 124.4 ± 4.2, 29.3 ± 2.4 and 21.7 ± 1.9, respectively. In vivo study revealed that topically given TT containing transfersomes, after secondary immunization, could elicit immune response (anti-TT-IgG) that was equivalent to one that produced following intramuscularly alum-adsorbed TT-based immunization. In comparison to transfersomes, niosomes and liposomes elicited weaker immune response. Thus transfersomes hold promise for effective non-invasive topical delivery of antigen(s).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11180030" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f8ce882259efc785721e63af8472c42b" rel="nofollow" data-download="{&quot;attachment_id&quot;:46839333,&quot;asset_id&quot;:11180030,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46839333/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="26997969" href="https://independent.academia.edu/VivekMishra44">Vivek Mishra</a><script data-card-contents-for-user="26997969" type="text/json">{"id":26997969,"first_name":"Vivek","last_name":"Mishra","domain_name":"independent","page_name":"VivekMishra44","display_name":"Vivek Mishra","profile_url":"https://independent.academia.edu/VivekMishra44?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11180030 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11180030"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11180030, container: ".js-paper-rank-work_11180030", }); });</script></li><li class="js-percentile-work_11180030 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11180030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_11180030"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11180030 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11180030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11180030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11180030]").text(description); $(".js-view-count-work_11180030").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11180030").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11180030"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>&nbsp;&nbsp;<a class="InlineList-item-text u-positionRelative">11</a>&nbsp;&nbsp;</div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4365" href="https://www.academia.edu/Documents/in/Vaccines">Vaccines</a>,&nbsp;<script data-card-contents-for-ri="4365" type="text/json">{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23890" href="https://www.academia.edu/Documents/in/Comparative_Study">Comparative Study</a>,&nbsp;<script data-card-contents-for-ri="23890" type="text/json">{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="41745" href="https://www.academia.edu/Documents/in/Pharmaceutics">Pharmaceutics</a>,&nbsp;<script data-card-contents-for-ri="41745" type="text/json">{"id":41745,"name":"Pharmaceutics","url":"https://www.academia.edu/Documents/in/Pharmaceutics?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a><script data-card-contents-for-ri="99234" type="text/json">{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11180030]'), work: {"id":11180030,"title":"Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: a comparative study","created_at":"2015-03-01T05:25:12.633-08:00","url":"https://www.academia.edu/11180030/Non_invasive_vaccine_delivery_in_transfersomes_niosomes_and_liposomes_a_comparative_study?f_ri=99234","dom_id":"work_11180030","summary":"Non-invasive vaccine delivery is a top priority for public health agencies because conventional immunization practices are unsafe and associated with numerous limitations. Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. Topical immunization (TI), introduction of antigen through topical application onto the intact skin, has many practical merits compared to injectable routes of administration. One of the possibilities for increasing the penetration of bioactives through the skin is the use of vesicular systems. Specially designed lipid vesicles are attracting intense attention and can be used for non-invasive antigen delivery. In the present study, elastic vesicle transfersomes, non-ionic surfactant vesicles (niosomes) and liposomes were used to study their relative potential in non-invasive delivery of tetanus toxoid (TT). Transfersomes, niosomes and liposomes were prepared and characterized for shape, size and entrapment efficiency. These vesicles were extruded through polycarbonate filter (50-nm pore size) to assess the elasticity of the vesicles. The immune stimulating activity of transfersomes, niosomes and liposomes were studied by measuring the serum anti-TT IgG titre following topical immunization. The immune response elicited by topical immunization was compared with that elicited by same dose of alum-adsorbed tetanus toxoid (AATT) given intramuscularly. The results indicate that optimal formulations of transfersomes, niosomes and liposomes could entrap 72.7 ± 3.4, 42.5 ± 2.4 and 41.3 ± 2.2% of antigen and their elasticity values were 124.4 ± 4.2, 29.3 ± 2.4 and 21.7 ± 1.9, respectively. In vivo study revealed that topically given TT containing transfersomes, after secondary immunization, could elicit immune response (anti-TT-IgG) that was equivalent to one that produced following intramuscularly alum-adsorbed TT-based immunization. In comparison to transfersomes, niosomes and liposomes elicited weaker immune response. Thus transfersomes hold promise for effective non-invasive topical delivery of antigen(s).","downloadable_attachments":[{"id":46839333,"asset_id":11180030,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26997969,"first_name":"Vivek","last_name":"Mishra","domain_name":"independent","page_name":"VivekMishra44","display_name":"Vivek Mishra","profile_url":"https://independent.academia.edu/VivekMishra44?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines?f_ri=99234","nofollow":false},{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=99234","nofollow":false},{"id":41745,"name":"Pharmaceutics","url":"https://www.academia.edu/Documents/in/Pharmaceutics?f_ri=99234","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234","nofollow":false},{"id":147066,"name":"Liposomes","url":"https://www.academia.edu/Documents/in/Liposomes?f_ri=99234"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems?f_ri=99234"},{"id":183266,"name":"Liposome","url":"https://www.academia.edu/Documents/in/Liposome?f_ri=99234"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=99234"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=99234"},{"id":1031068,"name":"Drug Carriers","url":"https://www.academia.edu/Documents/in/Drug_Carriers?f_ri=99234"},{"id":1384707,"name":"Niosomes","url":"https://www.academia.edu/Documents/in/Niosomes?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23837530" data-work_id="23837530" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23837530/The_first_report_of_viral_haemorrhagic_septicaemia_in_farmed_rainbow_trout_Oncorhynchus_mykiss_Walbaum_in_the_United_Kingdom">The first report of viral haemorrhagic septicaemia in farmed rainbow trout, Oncorhynchus mykiss (Walbaum), in the United Kingdom</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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class="InlineList-item-text" data-has-card-for-ri="173" href="https://www.academia.edu/Documents/in/Zoology">Zoology</a>,&nbsp;<script data-card-contents-for-ri="173" type="text/json">{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="13919" href="https://www.academia.edu/Documents/in/Fish_Diseases">Fish Diseases</a>,&nbsp;<script data-card-contents-for-ri="13919" type="text/json">{"id":13919,"name":"Fish Diseases","url":"https://www.academia.edu/Documents/in/Fish_Diseases?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="40867" href="https://www.academia.edu/Documents/in/United_Kingdom">United Kingdom</a>,&nbsp;<script data-card-contents-for-ri="40867" type="text/json">{"id":40867,"name":"United Kingdom","url":"https://www.academia.edu/Documents/in/United_Kingdom?f_ri=99234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="54433" href="https://www.academia.edu/Documents/in/Phylogeny">Phylogeny</a><script data-card-contents-for-ri="54433" type="text/json">{"id":54433,"name":"Phylogeny","url":"https://www.academia.edu/Documents/in/Phylogeny?f_ri=99234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23837530]'), work: {"id":23837530,"title":"The first report of viral haemorrhagic septicaemia in farmed rainbow trout, Oncorhynchus mykiss (Walbaum), in the United Kingdom","created_at":"2016-03-30T13:02:11.414-07:00","url":"https://www.academia.edu/23837530/The_first_report_of_viral_haemorrhagic_septicaemia_in_farmed_rainbow_trout_Oncorhynchus_mykiss_Walbaum_in_the_United_Kingdom?f_ri=99234","dom_id":"work_23837530","summary":null,"downloadable_attachments":[{"id":44237964,"asset_id":23837530,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46082527,"first_name":"Peter","last_name":"Dixon","domain_name":"independent","page_name":"PeterDixon9","display_name":"Peter Dixon","profile_url":"https://independent.academia.edu/PeterDixon9?f_ri=99234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=99234","nofollow":false},{"id":13919,"name":"Fish Diseases","url":"https://www.academia.edu/Documents/in/Fish_Diseases?f_ri=99234","nofollow":false},{"id":40867,"name":"United Kingdom","url":"https://www.academia.edu/Documents/in/United_Kingdom?f_ri=99234","nofollow":false},{"id":54433,"name":"Phylogeny","url":"https://www.academia.edu/Documents/in/Phylogeny?f_ri=99234","nofollow":false},{"id":65881,"name":"FISH","url":"https://www.academia.edu/Documents/in/FISH?f_ri=99234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=99234"},{"id":170652,"name":"Fisheries Sciences","url":"https://www.academia.edu/Documents/in/Fisheries_Sciences?f_ri=99234"},{"id":291274,"name":"Great Britain","url":"https://www.academia.edu/Documents/in/Great_Britain?f_ri=99234"},{"id":437726,"name":"Rainbow trout","url":"https://www.academia.edu/Documents/in/Rainbow_trout?f_ri=99234"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences?f_ri=99234"},{"id":988721,"name":"Oncorhynchus Mykiss","url":"https://www.academia.edu/Documents/in/Oncorhynchus_Mykiss?f_ri=99234"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay?f_ri=99234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_35426247" data-work_id="35426247" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/35426247/ADAMTS9_is_a_functional_tumor_suppressor_through_inhibiting_AKT_mTOR_pathway_and_associated_with_poor_survival_in_gastric_cancer">ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li 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href="https://www.academia.edu/attachments/55287301/download_file?st=MTczMjM4NjA1NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by&nbsp;<span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34296924" href="https://independent.academia.edu/XiaoxingLi">Xiaoxing Li</a><script data-card-contents-for-user="34296924" type="text/json">{"id":34296924,"first_name":"Xiaoxing","last_name":"Li","domain_name":"independent","page_name":"XiaoxingLi","display_name":"Xiaoxing Li","profile_url":"https://independent.academia.edu/XiaoxingLi?f_ri=99234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li 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III. 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href="https://www.academia.edu/25004169/Expanding_repertoire_in_the_oculomotor_periphery_selective_compartmental_function_in_rectus_extraocular_muscles">Expanding repertoire in the oculomotor periphery: selective compartmental function in rectus extraocular muscles</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25004169" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d43e84baae11bed2489a633f1bd9a3e9" rel="nofollow" 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study</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29145907" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6dacd6f2dd7d97af54326fee70122e9a" rel="nofollow" data-download="{&quot;attachment_id&quot;:49592395,&quot;asset_id&quot;:29145907,&quot;asset_type&quot;:&quot;Work&quot;,&quot;always_allow_download&quot;:false,&quot;track&quot;:null,&quot;button_location&quot;:&quot;work_strip&quot;,&quot;source&quot;:null,&quot;hide_modal&quot;:null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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