Journal of Pediatric Endocrinology and Metabolism

<!DOCTYPE html> <html lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head> <meta charset="utf-8"> <meta http-equiv="x-ua-compatible" content="ie=edge"> <title>Journal of Pediatric Endocrinology and Metabolism</title>  <link href="https://www.degruyter.com/journal/key/jpem/html" rel="canonical"></link>  <link rel="preload" href="/assets/fonts/montserrat-v15-latin-ext_cyrillic-ext-regular.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="preload" href="/assets/fonts/montserrat-v25-latin-ext_cyrillic-ext-500.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="preload" href="/assets/fonts/montserrat-v15-latin-ext_cyrillic-ext-700.woff2" as="font" type="font/woff2" crossorigin="anonymous">  <link rel="preload" href="/assets/fonts/merriweather-v30-latin-ext_cyrillic-ext-300.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="preload" href="/assets/fonts/merriweather-v22-latin-ext_cyrillic-ext-regular.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="preload" href="/assets/fonts/merriweather-v22-latin-ext_cyrillic-ext-700.woff2" as="font" type="font/woff2" crossorigin="anonymous">  <link rel="preload" href="/assets/stylesheets/fontawesome.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="stylesheet" media="all" href='/assets/stylesheets/02f295d1f6a8e9c282e7831cd493e8ff-bootstrap.purged.min.css' /> <link rel="stylesheet" media="all" href='/assets/stylesheets/028959ba60d23cf0bdb77660595d35e1-main.min.css' /> <link rel="stylesheet" media="all" href='/assets/stylesheets/13761c60ba5201f465803f3005ccd7ef-fontawesome-codes.css' /> <link rel="shortcut icon" type="image/x-icon" href='/assets/images/ec7d7606b4e2f3f921b5e1700948efb6-favicon.ico' /> <link rel="alternate" hreflang="en" href="https://www.degruyter.com/journal/key/jpem/html?lang=en" /> <link rel="alternate" hreflang="de" href="https://www.degruyter.com/journal/key/jpem/html?lang=de" /> <link rel="alternate" hreflang="x-default" href="https://www.degruyter.com/journal/key/jpem/html" />  <link rel="schema.dcterms" href="http://purl.org/dc/terms/"> <meta name="dcterms.rightsHolder" content="Walter de Gruyter GmbH"> <meta name="dcterms.rights" content="De Gruyter expressly reserves the right to use all content for commercial text and data mining within the meaning of Section 44b of the German Copyright Act."> <link rel="dns-prefetch" href="https://www.google-analytics.com" /> <meta name="google" content="notranslate" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <meta name="description" content="We are pleased to announce that on September 26, 2024, the members of the German Society for Pediatric and Adolescent Endocrinology and Diabetology, DGPAED , unanimously adopted the Journal of Pediatric Endocrinology and Metabolism as the official journal of DGPAED at their 1st Congress in Cologne. SPECIAL ISSUE ANNOUNCEMENT The Editors of the Journal of Pediatric Endocrinology and Metabolism ( JPEM ) are pleased to announce a call for submission for a special thematic issue of JPEM on Vitamin D Metabolism , which will be published in the first half of 2025. The submission deadline is January 31, 2024 . We invite you to submit at: https://mc.manuscriptcentral.com/jpem . Objective The Journal of Pediatric Endocrinology and Metabolism ( JPEM ) is a peer-reviewed journal that publishes cutting-edge articles on clinical investigations in pediatric endocrinology, diabetes, inherited metabolic disorders, metabolism and translational research. JPEM is an international journal devoted exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology, diabetes and metabolic diseases in its broadest sense, including research on epidemiology, pathophysiology, multidisciplinary management and technology, filling a gap at a time of rapid expansion in the field. JPEM is a hybrid journal published monthly in print and online. All contributions submitted for publication in JPEM are subject to single-anonymized peer review by at least two experts in the field, selected and invited by the Editor-in-Chief and a dedicated Editorial Team. JPEM publishes only English-language articles. Topics Pediatric Endocrinology // Pediatric Diabetes // Pediatric Obesity // Inherited Metabolic Diseases // Neonates/Neonatal Screening // Hormonal Disorders and Therapy // Adrenal Disorders // Pituitary Disorders // Thyroid Disorders // Disorders of Bone, Calcium and Vitamin D Metabolism // Growth Disorders // Endocrine Cancers // Disorders of Gonads and Puberty // Disorders of Sex Differentiation, Gender Dysphoria // Psychosocial Aspects of Chronic Conditions in Pediatric Endocrinology and Diabetology // Multidisciplinary Care for Children and Their Families Article formats Original Article, Review Article, Mini Review, Opinion Paper, Perspectives, Editorial, Case Report, Case Report and Review of the Literature, Short Communication, Letter to the Editor and Reply, Guidelines and Recommendations, Congress Abstracts Instructions for Authors Submission Checklist Template for Ethical and Legal Declarations"/> <meta property="og:url" content="https://www.degruyter.com/journal/key/jpem/html"/><meta property="og:site_name" content="De Gruyter"/><meta property="og:title" content="Journal of Pediatric Endocrinology and Metabolism"/><meta property="og:type" content="website"/><meta property="og:locale" content="en"/><meta property="og:image" content="https://www.degruyter.com/document/cover/journal_key/JPEM/product"/><meta property="og:image:type" content="image/jpeg"/><meta property="og:description" content="We are pleased to announce that on September 26, 2024, the members of the German Society for Pediatric and Adolescent Endocrinology and Diabetology, DGPAED , unanimously adopted the Journal of Pediatric Endocrinology and Metabolism as the official journal of DGPAED at their 1st Congress in Cologne. SPECIAL ISSUE ANNOUNCEMENT The Editors of the Journal of Pediatric Endocrinology and Metabolism ( JPEM ) are pleased to announce a call for submission for a special thematic issue of JPEM on Vitamin D Metabolism , which will be published in the first half of 2025. The submission deadline is January 31, 2024 . We invite you to submit at: https://mc.manuscriptcentral.com/jpem . Objective The Journal of Pediatric Endocrinology and Metabolism ( JPEM ) is a peer-reviewed journal that publishes cutting-edge articles on clinical investigations in pediatric endocrinology, diabetes, inherited metabolic disorders, metabolism and translational research. JPEM is an international journal devoted exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology, diabetes and metabolic diseases in its broadest sense, including research on epidemiology, pathophysiology, multidisciplinary management and technology, filling a gap at a time of rapid expansion in the field. JPEM is a hybrid journal published monthly in print and online. All contributions submitted for publication in JPEM are subject to single-anonymized peer review by at least two experts in the field, selected and invited by the Editor-in-Chief and a dedicated Editorial Team. JPEM publishes only English-language articles. Topics Pediatric Endocrinology // Pediatric Diabetes // Pediatric Obesity // Inherited Metabolic Diseases // Neonates/Neonatal Screening // Hormonal Disorders and Therapy // Adrenal Disorders // Pituitary Disorders // Thyroid Disorders // Disorders of Bone, Calcium and Vitamin D Metabolism // Growth Disorders // Endocrine Cancers // Disorders of Gonads and Puberty // Disorders of Sex Differentiation, Gender Dysphoria // Psychosocial Aspects of Chronic Conditions in Pediatric Endocrinology and Diabetology // Multidisciplinary Care for Children and Their Families Article formats Original Article, Review Article, Mini Review, Opinion Paper, Perspectives, Editorial, Case Report, Case Report and Review of the Literature, Short Communication, Letter to the Editor and Reply, Guidelines and Recommendations, Congress Abstracts Instructions for Authors Submission Checklist Template for Ethical and Legal Declarations"/><meta property="og:locale:alternate" content="de"/> <script nonce="DX3icSCq2/IwIiH8LG3PyA=="> // Define dataLayer and the gtag function. window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} function getCookieValue(name){ const regex = new RegExp(`(^| )${name}=([^;]+)`) const match = document.cookie.match(regex) if (match) { return match[2] } } // Set default consent to 'denied' as a placeholder // Determine actual values based on your own requirements const acceptCookies = getCookieValue('acceptcookies') === "true"; const defaultSettings = (acceptCookies) => ({ 'ad_storage': acceptCookies ? 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Your documents are now available to view.</p> <div id="orderCompleteItemList"> </div> </div> </div> </div> </div> <main id="main" class='language_en min-vh-100 '> <div class="row no-theme-gutter-x"> <div id="journalContent" class="content offset-lg-1 col-lg-8 py-sm-5 px-4" data-journalkey="jpem"> <div class="d-none analyticsHolder" data-publisherCode='DEG' data-license='restricted' data-languages='en' data-publisher='De Gruyter' data-contentName='Journal of Pediatric Endocrinology and Metabolism' ></div> <div class="row pb-5"> <div class="col-auto mobile-product-cover-image mx-auto d-block "> <div class="cover-image-container position-relative"> <img class="coverImage ga_cover_image_product" alt="journal: Journal of Pediatric Endocrinology and Metabolism" src="/document/cover/journal_key/JPEM/product_pages" width="200" height="auto" loading="lazy"/> <span class="coverImageText journalImpactFactor ga_impactfactor">Impact Factor: 1.3</span> </div> </div> <div class="col"> <div class="mb-2"> <span class="d-none itemAuthorized"> <span class="fa fas fa-icon-authorized"></span> <span class="accessAccessible me-2">Licensed</span> </span> <span class="d-none itemNotAuthorized"> <span class="fa fas fa-icon-not-authorized"></span> <span class="d-none notAuthUserLoggedIn accessRequireAuth me-2">Unlicensed</span> <span class="d-none notAuthUserLoggedOut accessRequireAuth me-2">Requires Authentication</span> </span> <span class="metadataInfoMainContent">Published since January 1, 1985 </span> </div> <h1>Journal of Pediatric Endocrinology and Metabolism</h1> <h2 class="journalSubtitle">Official Journal of the German Society for Pediatric and Adolescent Endocrinology and Diabetology (DGPAED)</h2> <div class="issn metadataAndContributorsFont"> <span>ISSN:</span> <span>2191-0251</span> </div> <div class="contributors"> <div class="editorInChief"> <span class="metadataAndContributorsFont">Editor-in-Chief: Clemens Kamrath</span> </div> </div> <div class="mt-3"> <a href="http://mc.manuscriptcentral.com/jpem" class="btn btn-outline-primary fw-bold ga_submit">Submit manuscript</a> </div> </div> </div> <div class="row"> <div class="col px-2 pe-md-5"> <nav class="px-2 px-lg-0"> <tab-nav> <ul class="nav" role="tablist"> <li class="nav-item" role="presentation"> <a href="#overview" id="overviewTab" data-bs-toggle="tab" role="tab" class="nav-link active ga_tab_overview"> <div class="productsTabLink">Overview</div> </a>. </li> <li class="nav-item" role="presentation"> <a href="#issues" id="issuesTab" data-bs-toggle="tab" role="tab" class="nav-link ga_tab_issues"> <div class="productsTabLink">Issues</div> </a> </li> <li class="nav-item " role="presentation"> <a href="#ranking" id="rankingTab" data-bs-toggle="tab" role="tab" class="nav-link ga_tab_ranking"> <div class="productsTabLink">Ranking</div> </a> </li> <li class="nav-item " role="presentation"> <a href="#submit" id="submitTab" data-bs-toggle="tab" role="tab" class="nav-link ga_tab_submit"> <div class="productsTabLink">Submit</div> </a> </li> <li class="nav-item " role="presentation"> <a href="#editorial" id="editorialTab" data-bs-toggle="tab" role="tab" class="nav-link ga_tab_editorial"> <div class="productsTabLink">Editorial</div> </a> </li> <li class="d-none nav-item" role="presentation"> <a href="#latestIssue" id="latestIssueTab" data-bs-toggle="tab" role="tab" class="nav-link ga_tab_latest_issue"> <div class="productsTabLink">Latest issue</div> </a> </li> </ul> </tab-nav> <div class="tab-content"> <div class="tab-pane show active mt-5 mb-4 pe-lg-5" id="overview" role="tabpanel" aria-labelledby="overviewTab"> <h2 class="screen-reader">Overview</h2> <div> <div class="productInfo pb-3"> <h3>About this journal</h3> <div class="metadataInfoFont"> <p> We are pleased to announce that on September 26, 2024, the members of the German Society for Pediatric and Adolescent Endocrinology and Diabetology, <a href="https://dgpaed.de/">DGPAED</a>, unanimously adopted the <em>Journal of Pediatric Endocrinology and Metabolism</em> as the official journal of DGPAED at their 1st Congress in Cologne. </p> <p> <strong>SPECIAL ISSUE ANNOUNCEMENT</strong> </p> <p> The Editors of the <em>Journal of Pediatric Endocrinology and Metabolism</em> (<em>JPEM</em>) are pleased to announce a call for submission for a special thematic issue of <em>JPEM</em> on <strong>Vitamin D Metabolism</strong>, which will be published in the first half of 2025. The submission deadline is <strong>January 31, 2024</strong>. We invite you to submit at: <a href="https://mc.manuscriptcentral.com/jpem."><strong><u>https://mc.manuscriptcentral.com/jpem</u></strong>.</a> </p> <p> <strong>Objective<br /></strong>The <em>Journal of Pediatric Endocrinology and Metabolism</em> (<em>JPEM</em>) is a peer-reviewed journal that publishes cutting-edge articles on clinical investigations in pediatric endocrinology, diabetes, inherited metabolic disorders, metabolism and translational research. <em>JPEM</em> is an international journal devoted exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. <em>JPEM</em> is a high-quality journal dedicated to pediatric endocrinology, diabetes and metabolic diseases in its broadest sense, including research on epidemiology, pathophysiology, multidisciplinary management and technology, filling a gap at a time of rapid expansion in the field.<br /><em>JPEM</em> is a hybrid journal published monthly in print and online. All contributions submitted for publication in <em>JPEM</em> are subject to single-anonymized peer review by at least two experts in the field, selected and invited by the Editor-in-Chief and a dedicated Editorial Team. <em>JPEM</em> publishes only English-language articles. </p> <p> <strong>Topics</strong><br />Pediatric Endocrinology // Pediatric Diabetes // Pediatric Obesity // Inherited Metabolic Diseases // Neonates/Neonatal Screening // Hormonal Disorders and Therapy // Adrenal Disorders // Pituitary Disorders // Thyroid Disorders // Disorders of Bone, Calcium and Vitamin D Metabolism // Growth Disorders // Endocrine Cancers // Disorders of Gonads and Puberty // Disorders of Sex Differentiation, Gender Dysphoria // Psychosocial Aspects of Chronic Conditions in Pediatric Endocrinology and Diabetology // Multidisciplinary Care for Children and Their Families </p> <p> <strong>Article formats<br /></strong>Original Article, Review Article, Mini Review, Opinion Paper, Perspectives, Editorial, Case Report, Case Report and Review of the Literature, Short Communication, Letter to the Editor and Reply, Guidelines and Recommendations, Congress Abstracts </p> <ul> <li> <a href="https://www.degruyter.com/publication/journal_key/JPEM/downloadAsset/JPEM_Instructions%20for%20Authors.pdf"><strong>Instructions for Authors</strong></a> </li> <li> <a href="https://www.degruyter.com/publication/journal_key/JPEM/downloadAsset/JPEM_Submission%20Checklist.pdf"><strong>Submission Checklist</strong></a> </li> <li> <p> <a href="https://www.degruyter.com/publication/journal_key/JPEM/downloadAsset/JPEM_Template%20for%20Ethical%20and%20Legal%20Declarations.docx"><strong>Template for Ethical and Legal Declarations</strong></a> </p> </li> </ul> </div> </div> </div> <div> <div class="productInfo pb-3"> <h3>Your Benefits</h3> <div class="metadataInfoFont"> <ul> <li> Specialized, comprehensive and translational research </li> <li> High quality peer-review </li> <li> Rapid online publication of contributions </li> <li> No submission and publication fee </li> <li> Listed in major indexing setrvices such as SCIE, PubMed or Scopus </li> <li> Each article easily discoverable because of Search Engine Optimization (SEO) and comprehensive <a href="https://www.degruyter.com/cms/pages/abstracting-indexing">abstracting and indexing services</a> </li> <li> Secure archiving by De Gruyter and the independent archiving service <a href="http://www.portico.org/digital-preservation/">Portico</a> </li> <li> <p> Authors have the option of publishing their articles under the <a href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution (CC-BY-4.0) open access license</a>. Open access allows authors to retain copyright and share their findings with the scientific community without restrictions. Authors who belong to an institution that has an <a href="https://www.degruyter.com/publishing/publications/openaccess/open-access-agreements?lang=en">agreement with the publisher</a> can publish open access without paying an article processing charge (APC) or at a considerable discount </p> </li> </ul> </div> </div> </div> <div> </div> <div> </div> <div> </div> <div> <div class="productInfo pb-3"> <h3>Abstracting and Indexing</h3> <div class="metadataInfoFont"> <!doctype html public "-//w3c//dtd html 4.0 transitional//en"> <html><head> <meta http-equiv=content-type content="text/html; charset=iso-8859-1"> <meta content="mshtml 6.00.6000.17104" name=generator></head> <body> <P><EM>Journal of Pediatric Endocrinology and Metabolism</EM> is covered by the following services:</P> <UL><LI>Baidu Scholar</LI><LI>Cabells Journalytics</LI><LI>CABI (over 50 subsections)</LI><LI>Chemical Abstracts Service (CAS) - CAplus</LI><LI>Chemical Abstracts Service (CAS) - SciFinder</LI><LI>CNKI Scholar (China National Knowledge Infrastructure)</LI><LI>CNPIEC - cnpLINKer</LI><LI>Dimensions</LI><LI>EBSCO (relevant databases)</LI><LI>EBSCO Discovery Service</LI><LI>EMBASE</LI><LI>Genamics JournalSeek</LI><LI>Google Scholar</LI><LI>ICAP Alcohol Information Databases</LI><LI>Index Copernicus</LI><LI>Japan Science and Technology Agency (JST)</LI><LI>J-Gate</LI><LI>Journal Citation Reports/Science Edition</LI><LI>JournalGuide</LI><LI>Medline</LI><LI>MyScienceWork</LI><LI>Naver Academic</LI><LI>Naviga (Softweco)</LI><LI>Pathway Studio</LI><LI>Primo Central (ExLibris)</LI><LI>ProQuest (relevant databases)</LI><LI>Publons</LI><LI>PubMed</LI><LI>PubsHub</LI><LI>QOAM (Quality Open Access Market)</LI><LI>ReadCube</LI><LI>Reaxys</LI><LI>ScienceON (Korea Institute of Science and Technology Information)</LI><LI>Scilit</LI><LI>SCImago (SJR)</LI><LI>SCOPUS</LI><LI>Semantic Scholar</LI><LI>Sherpa/RoMEO</LI><LI>Summon (ProQuest)</LI><LI>TDNet</LI><LI>Text Mining</LI><LI>Ulrich's Periodicals Directory/ulrichsweb</LI><LI>WanFang Data</LI><LI>Web of Science - Biological Abstracts</LI><LI>Web of Science - BIOSIS Previews</LI><LI>Web of Science - Current Contents/Life Sciences</LI><LI>Web of Science - Prous Science Integrity</LI><LI>Web of Science - Science Citation Index</LI><LI>Web of Science - Science Citation Index Expanded</LI><LI>WorldCat (OCLC)</LI><LI>X-MOL</LI><LI>Yewno Discover</LI></UL></body></html> </div> </div> </div> <div class="supplementaryMaterials mb-3"> <h3 class="subTitleMainContent mb-3"> Supplementary Materials </h3> <ul class="list-unstyled supplementaryMaterialList"> <li class="supplementaryMaterialItem mb-2"> <a href="/publication/journal_key/JPEM/downloadAsset/JPEM_Instructions%20for%20Authors.pdf" class="ga_download_supplementary fw-bold"> <span class="fa fas fa-file-pdf me-2"></span> <span class="linkAnimation pb-0">Instructions for Authors</span> </a> </li> <li class="supplementaryMaterialItem mb-2"> <a href="/publication/journal_key/JPEM/downloadAsset/JPEM_Submission%20Checklist.pdf" class="ga_download_supplementary fw-bold"> <span class="fa fas fa-file-pdf me-2"></span> <span class="linkAnimation pb-0">Submission Checklist</span> </a> </li> <li class="supplementaryMaterialItem mb-2"> <a href="/publication/journal_key/JPEM/downloadAsset/JPEM_Template%20for%20Ethical%20and%20Legal%20Declarations.docx" class="ga_download_supplementary fw-bold"> <span class="fa fas fa-file-word me-2"></span> <span class="linkAnimation pb-0">Template for Ethical and Legal Declarations</span> </a> </li> </ul> </div> <div class="pb-3"> <h3>Topics</h3> <ul class="list-inline pt-2 subjects"> <li class="list-inline-item mb-2 subject"> <a class='subjectSearchLink productsTopicLink ga_productsTopicLink' title='Search for “Clinical Medicine”' href='/search?query=*&subjectFacet=MD-04'> Clinical Medicine </a> </li> <li class="list-inline-item mb-2 subject"> <a class='subjectSearchLink productsTopicLink ga_productsTopicLink' title='Search for “Endocrinology, Diabetology”' href='/search?query=*&subjectFacet=MD-04-03-02'> Endocrinology, Diabetology </a> </li> <li class="list-inline-item mb-2 subject"> <a class='subjectSearchLink productsTopicLink ga_productsTopicLink' title='Search for “Internal Medicine”' href='/search?query=*&subjectFacet=MD-04-03'> Internal Medicine </a> </li> <li class="list-inline-item mb-2 subject"> <a class='subjectSearchLink productsTopicLink ga_productsTopicLink' title='Search for “Medicine”' href='/search?query=*&subjectFacet=MD'> Medicine </a> </li> </ul> </div>  <div class="pb-3"> <h3>External Links</h3> <ul class="list-unstyled pt-2"> <li class="mb-2"><a class="linkAnimation" title='Online Submission of Manuscripts' href='http://mc.manuscriptcentral.com/jpem'>Online Submission of Manuscripts</a></li> <li class="mb-2"><a class="linkAnimation" title='License Agreement' href='http://www.degruyter.com/dg/page/308/copyright-agreement'>License Agreement</a></li> <li class="mb-2"><a class="linkAnimation" title='Publish your Article' href='https://www.degruyter.com/publishing/for-authors/for-journal-authors/publish-your-article'>Publish your Article</a></li> <li class="mb-2"><a class="linkAnimation" title='Publishing Ethics Policy' href='https://www.degruyter.com/publishing/for-authors/for-journal-authors/publishing-ethics'>Publishing Ethics Policy</a></li> <li class="mb-2"><a class="linkAnimation" title='Data Sharing Policy' href='https://www.degruyter.com/publishing/services/rights-and-permissions/our-data-sharing-policy?lang=en'>Data Sharing Policy</a></li> <li class="mb-2"><a class="linkAnimation" title='Open Access Policy' href='https://www.degruyter.com/cms/pages/open-access'>Open Access Policy</a></li> <li class="mb-2"><a class="linkAnimation" title='Abstracting & Indexing' href='https://www.degruyter.com/cms/pages/abstracting-indexing?lang=en'>Abstracting & Indexing</a></li> <li class="mb-2"><a class="linkAnimation" title='Rights & Permissions' href='https://www.degruyter.com/cms/pages/rights-permissions'>Rights & Permissions</a></li> <li class="mb-2"><a class="linkAnimation" title='Repository Policy' href='https://www.degruyter.com/publishing/services/rights-and-permissions/repository-policy-for-journal-publications-test'>Repository Policy</a></li> <li class="mb-2"><a class="linkAnimation" title='Privacy Policy' href='https://www.degruyter.com/cms/pages/privacy-policy?lang=en'>Privacy Policy</a></li> <li class="mb-2"><a class="linkAnimation" title='Sharing your Work' href='https://www.degruyter.com/publishing/for-authors/for-journal-authors/sharing-your-work'>Sharing your Work</a></li> <li class="mb-2"><a class="linkAnimation" title='German Society for Pediatric and Adolescent Endocrinology and Diabetology (DGPAED)' href='https://dgpaed.de/'>German Society for Pediatric and Adolescent Endocrinology and Diabetology (DGPAED)</a></li> <li class="mb-2"><a class="linkAnimation" title='Ja-Ped 2025: 2nd Annual Meeting of DGPAED. Leipzig-Halle, November 13-15, 2025' href='https://ja-ped.de/'>Ja-Ped 2025: 2nd Annual Meeting of DGPAED. Leipzig-Halle, November 13-15, 2025</a></li> <li class="mb-2"><a class="linkAnimation" title='2024 Reviewer Thank You' href='https://www.degruyter.com/document/doi/10.1515/jpem-2024-2001/html'>2024 Reviewer Thank You</a></li> </ul> </div> </div> <div class="tab-pane mt-5 mb-4" id="issues" role="tabpanel" aria-labelledby="issuesTab"> <h2 class="screen-reader">Issues</h2> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-0" data-bs-target="#expandVolume-0" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-0"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Ahead of Print / Just Accepted </a> </h3> <ul id="expandVolume-0" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/0/0/html"> Ahead of Print / Just Accepted </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-38" data-bs-target="#expandVolume-38" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-38"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 38 (2025) </a> </h3> <ul id="expandVolume-38" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/38/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/38/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/38/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-37" data-bs-target="#expandVolume-37" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-37"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 37 (2024) </a> </h3> <ul id="expandVolume-37" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/37/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-36" data-bs-target="#expandVolume-36" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-36"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 36 (2023) </a> </h3> <ul id="expandVolume-36" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/36/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-35" data-bs-target="#expandVolume-35" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-35"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 35 (2022) </a> </h3> <ul id="expandVolume-35" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/35/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-34" data-bs-target="#expandVolume-34" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-34"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 34 (2021) </a> </h3> <ul id="expandVolume-34" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/34/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-33" data-bs-target="#expandVolume-33" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-33"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 33 (2020) </a> </h3> <ul id="expandVolume-33" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/33/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-32" data-bs-target="#expandVolume-32" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-32"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 32 (2019) </a> </h3> <ul id="expandVolume-32" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/32/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-31" data-bs-target="#expandVolume-31" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-31"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 31 (2018) </a> </h3> <ul id="expandVolume-31" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/31/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-30" data-bs-target="#expandVolume-30" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-30"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 30 (2017) </a> </h3> <ul id="expandVolume-30" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/30/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-29" data-bs-target="#expandVolume-29" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-29"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 29 (2016) </a> </h3> <ul id="expandVolume-29" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/29/1/html"> Issue 1 <span class="text-dark fw-bold">HIGHLIGHT: INHERITED METABOLIC DISORDERS IN NEWBORNS</span> </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-28" data-bs-target="#expandVolume-28" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-28"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 28 (2015) </a> </h3> <ul id="expandVolume-28" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/28/11-12/html"> Issue 11-12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/28/9-10/html"> Issue 9-10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/28/7-8/html"> Issue 7-8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/28/5-6/html"> Issue 5-6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/28/3-4/html"> Issue 3-4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/28/1-2/html"> Issue 1-2 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-27" data-bs-target="#expandVolume-27" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-27"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 27 (2014) </a> </h3> <ul id="expandVolume-27" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/27/11-12/html"> Issue 11-12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/27/9-10/html"> Issue 9-10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/27/7-8/html"> Issue 7-8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/27/5-6/html"> Issue 5-6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/27/3-4/html"> Issue 3-4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/27/1-2/html"> Issue 1-2 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-26" data-bs-target="#expandVolume-26" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-26"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 26 (2013) </a> </h3> <ul id="expandVolume-26" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/26/11-12/html"> Issue 11-12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/26/9-10/html"> Issue 9-10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/26/7-8/html"> Issue 7-8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/26/5-6/html"> Issue 5-6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/26/3-4/html"> Issue 3-4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/26/1-2/html"> Issue 1-2 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-25" data-bs-target="#expandVolume-25" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-25"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 25 (2012) </a> </h3> <ul id="expandVolume-25" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/25/11-12/html"> Issue 11-12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/25/9-10/html"> Issue 9-10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/25/7-8/html"> Issue 7-8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/25/5-6/html"> Issue 5-6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/25/3-4/html"> Issue 3-4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/25/1-2/html"> Issue 1-2 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-24" data-bs-target="#expandVolume-24" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-24"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 24 (2011) </a> </h3> <ul id="expandVolume-24" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/24/11-12/html"> Issue 11-12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/24/9-10/html"> Issue 9-10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/24/7-8/html"> Issue 7-8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/24/5-6/html"> Issue 5-6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/24/3-4/html"> Issue 3-4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/24/1-2/html"> Issue 1-2 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-23" data-bs-target="#expandVolume-23" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-23"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 23 (2010) </a> </h3> <ul id="expandVolume-23" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/23/1-2/html"> Issue 1-2 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-22" data-bs-target="#expandVolume-22" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-22"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 22 (2009) </a> </h3> <ul id="expandVolume-22" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/22/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-21" data-bs-target="#expandVolume-21" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-21"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 21 (2008) </a> </h3> <ul id="expandVolume-21" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/21/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-20" data-bs-target="#expandVolume-20" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-20"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 20 (2007) </a> </h3> <ul id="expandVolume-20" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/20/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-19" data-bs-target="#expandVolume-19" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-19"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 19 (2006) </a> </h3> <ul id="expandVolume-19" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/19/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-18" data-bs-target="#expandVolume-18" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-18"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 18 (2005) </a> </h3> <ul id="expandVolume-18" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/18/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-17" data-bs-target="#expandVolume-17" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-17"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 17 (2004) </a> </h3> <ul id="expandVolume-17" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/12/html"> Issue 12 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/11/html"> Issue 11 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/10/html"> Issue 10 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/17/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-16" data-bs-target="#expandVolume-16" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-16"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 16 (2003) </a> </h3> <ul id="expandVolume-16" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/16/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-15" data-bs-target="#expandVolume-15" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-15"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 15 (2002) </a> </h3> <ul id="expandVolume-15" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/15/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-14" data-bs-target="#expandVolume-14" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-14"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 14 (2001) </a> </h3> <ul id="expandVolume-14" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/s2/html"> Issue s2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/14/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-13" data-bs-target="#expandVolume-13" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-13"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 13 (2000) </a> </h3> <ul id="expandVolume-13" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/s2/html"> Issue s2 <span class="text-dark fw-bold">Supplement</span> </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/9/html"> Issue 9 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/8/html"> Issue 8 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/7/html"> Issue 7 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/13/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-12" data-bs-target="#expandVolume-12" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-12"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 12 (1999) </a> </h3> <ul id="expandVolume-12" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/12/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/12/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/12/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/12/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/12/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/12/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/12/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-11" data-bs-target="#expandVolume-11" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-11"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 11 (1998) </a> </h3> <ul id="expandVolume-11" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/11/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/11/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/11/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/11/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/11/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/11/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/11/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-10" data-bs-target="#expandVolume-10" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-10"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 10 (1997) </a> </h3> <ul id="expandVolume-10" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/10/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/10/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/10/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/10/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/10/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/10/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/10/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-9" data-bs-target="#expandVolume-9" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-9"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 9 (1996) </a> </h3> <ul id="expandVolume-9" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/9/6/html"> Issue 6 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/9/5/html"> Issue 5 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/9/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/9/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/9/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/9/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/9/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-8" data-bs-target="#expandVolume-8" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-8"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 8 (1995) </a> </h3> <ul id="expandVolume-8" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/8/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/8/Supplement/html"> Issue Supplement </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/8/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/8/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/8/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-7" data-bs-target="#expandVolume-7" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-7"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 7 (1994) </a> </h3> <ul id="expandVolume-7" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/7/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/7/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/7/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/7/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-6" data-bs-target="#expandVolume-6" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-6"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 6 (1993) </a> </h3> <ul id="expandVolume-6" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/6/3-4/html"> Issue 3-4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/6/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-5" data-bs-target="#expandVolume-5" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-5"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 5 (1992) </a> </h3> <ul id="expandVolume-5" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/5/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/5/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/5/1-2/html"> Issue 1-2 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-4" data-bs-target="#expandVolume-4" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-4"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 4 (1991) </a> </h3> <ul id="expandVolume-4" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/4/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/4/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/4/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-3" data-bs-target="#expandVolume-3" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-3"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 3 (1989) </a> </h3> <ul id="expandVolume-3" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/3/3/html"> Issue 3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/3/2/html"> Issue 2 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/3/1/html"> Issue 1 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-2" data-bs-target="#expandVolume-2" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-2"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 2 (1987) </a> </h3> <ul id="expandVolume-2" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/2/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/2/2-3/html"> Issue 2-3 </a> </span> </li> </ul> </div> <div class="volume mt-3"> <h3 class="volumeHeading"> <a class="volumeExpander text-dark text-decoration-none" href="#expandVolume-1" data-bs-target="#expandVolume-1" data-bs-toggle="collapse" aria-expanded="false" aria-controls="expandVolume-1"> <span class="volumeExpanderIcon fa fas fa-plus-squared-alt"></span> Volume 1 (1985) </a> </h3> <ul id="expandVolume-1" class="issueList ms-xl-4 dashedList collapse" aria-expanded="false"> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/1/4/html"> Issue 4 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/1/2-3/html"> Issue 2-3 </a> </span> </li> <li class="issue pb-3"> <span> <a class="text-dark" href="/journal/key/jpem/1/1/html"> Issue 1 </a> </span> </li> </ul> </div> </div> <div class="tab-pane mt-5 mb-4" id="ranking" role="tabpanel" aria-labelledby="rankingTab"> <h2 class="screen-reader">Ranking</h2> <table class="table table-striped table-borderless"> <tbody> <tr> <td class="text-dark fw-bold col-auto">Journal Impact Factor</td> <td class="text-dark col-auto">1.3</td> <td class="text-dark col-auto">2023, Journal Citation Reports (Clarivate, 2024)</td> </tr> <tr> <td class="text-dark fw-bold col-auto">5-year Journal Impact Factor</td> <td class="text-dark col-auto">1.4</td> <td class="text-dark col-auto">2023, Journal Citation Reports (Clarivate, 2024)</td> </tr> <tr> <td class="text-dark fw-bold col-auto">Journal Citation Indicator</td> <td class="text-dark col-auto">0.45</td> <td class="text-dark col-auto">2023, Journal Citation Reports (Clarivate, 2024)</td> </tr> <tr> <td class="text-dark fw-bold col-auto">CiteScore</td> <td class="text-dark col-auto">2.7</td> <td class="text-dark col-auto">2023, Scopus (Elsevier B.V., 2024)</td> </tr> <tr> <td class="text-dark fw-bold col-auto">SCImago Journal Rank</td> <td class="text-dark col-auto">0.456</td> <td class="text-dark col-auto">2023, SJR (Scimago Lab, 2024; Data Source: Scopus)</td> </tr> <tr> <td class="text-dark fw-bold col-auto">Source Normalized Impact per Paper</td> <td class="text-dark col-auto">0.565</td> <td class="text-dark col-auto">2023, CWTS Journal Indicators (CWTS B.V., 2024; Data Source: Scopus)</td> </tr> </tbody> </table> <div><a href="/publishing/services/for-journal-authors/abstracting-and-indexing" target="_blank">More information about journal rankings</a></div> </div> <div class="tab-pane mt-5 mb-4" id="submit" role="tabpanel" aria-labelledby="submitTab"> <h2 class="screen-reader">Submit</h2> <div> <div class="productInfo pb-3"> <h3>Submit</h3> <div class="metadataInfoFont"> <ul> <li> You can easily submit your manuscript online. Simply go to <a href="https://mc.manuscriptcentral.com/jpem">https://mc.manuscriptcentral.com/jpem</a> and you will be guided through the entire submission and publishing process. </li> <li> Prepare your manuscript according to the <a href="https://www.degruyter.com/publication/journal_key/JPEM/downloadAsset/JPEM_Instructions%20for%20Authors.pdf">author guidelines</a> and <a href="https://www.degruyter.com/publication/journal_key/JPEM/downloadAsset/JPEM_Submission%20Checklist.pdf">submission checklist</a><strong><u>.</u></strong> </li> <li> The <em>Journal of Pediatric Endocrinology and Metabolism</em> follows <a href="https://degruyter-live-craftcms-assets.s3.amazonaws.com/Policy-3_20240625.pdf">Tier 3</a> of our <a href="https://www.degruyter.com/publishing/services/rights-and-permissions/our-data-sharing-policy?lang=en">Data Sharing Policy</a>. Authors are required to provide a data availability statement. Please refer to the Data Sharing Policy for guidance on how to write a data availability statement. </li> <li> As a condition of submission, the <a href="https://www.degruyter.com/publication/journal_key/JPEM/downloadAsset/JPEM_Template%20for%20Ethical%20and%20Legal%20Declarations.docx">Template for Ethical and Legal Declarations</a> must be customized by the submitting author on behalf of all others and <strong>uploaded as a separate Word file.</strong> </li> <li> If you have any general questions please visit our <a href="https://www.degruyter.com/publishing/about-us/new-website-faqs/authors-editors">FAQ page</a> for authors. </li> </ul> </div> </div> </div> </div> <div class="tab-pane mt-5 mb-4" id="editorial" role="tabpanel" aria-labelledby="editorialTab"> <h2 class="screen-reader">Editorial</h2> <div> <div class="productInfo pb-3"> <h3>Editorial</h3> <div class="metadataInfoFont"> <p> <strong>Editor-in-Chief</strong><br />Clemens Kamrath, University of Freiburg, Faculty of Medicine, Centre of Child and Adolescent Health, Division of Pediatric Endocrinology and Diabetes, Freiburg, Germany<br /><a href="mailto:Clemens.Kamrath@uniklinik-freiburg.de">Clemens.Kamrath@uniklinik-freiburg.de</a> </p><strong></strong> <p> <strong>Founding Editor</strong><br />Harry J. Hirsch, Jerusalem, Israel </p> <p> <strong>Honorary Editors<br /></strong>Zvi Laron, Petah Tikva, Israel<br />Zvi Zadik, Rehovot, Israel </p><strong></strong> <p> <strong>Associate Editors</strong> </p> <ul> <strong></strong> <li> <strong>Abdullah Bereket</strong>, Marmara University Hospital, Department of Pediatrics, Division of Pediatric Endocrinology, Istanbul, Türkiye </li> <li> <strong>Mehul Dattani</strong>, Great Ormond Street Hospital, Endocrinology, London, United Kingdom </li> <li> <strong>Jan Idkowiak</strong>, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom </li> <li> <strong>Sebastian Kummer</strong>, University Children's Hospital Düsseldorf, Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf, Germany </li> <li> <strong>Feihong Luo</strong>, Chilren's Hospital of Fudan University, Pediartic Endocirnology and Inborn Metabolic Diseases, Shanghai, China </li> <li> <strong>Raja Padidela,</strong> Central Manchester University Hospitals, NHS Foundation Trust, Department of Paediatric Endocrinology, Manchester, United Kingdom </li> <li> <strong>Burcu Öztürk-Hişmi,</strong> Pediatrics, Marmara University School of Medicine, Istanbul, Türkiye </li> <li> <strong>Annette Richter-Unruh,</strong> Pediatric Endocrinology, MVZ Dortmund, Dortmund, Germany </li> <li> <strong>Serap Turan</strong>, Pediatric Endocrinology, Marmara University, Istanbul, Türkiye </li> <p> </p> </ul> <p> <strong>Editorial Board</strong><br />Tadej Battelino, Ljubljana, Slovenia<br />Claudia Boettcher, Berne, Switzerland<br />Fernando Cassorla, Santiago de Chile, Chile<br />George Chrousos, Athens, Greece<br />Wayne Cutfield, Auckland, New Zealand<br />Johnny Deladoey, Montreal, QC, Canada<br />Rasha Tarif Hamza, Cairo, Egypt<br />Eli Hershkovitz, Beersheba, Israel<br />Stephen LaFranchi, Portland, OR, USA<br />Roberto Lanes, Caracas, Venezuela<br />Warren Lee, Singapore<br />Angelika Mohn, Chieti, Italy<br />Margaret Zacharin, Parkville, Australia<br /><br /><strong>Managing Editor<br /></strong>Anna Kirstein, Leipzig, Germany<br /><a href="mailto:Anna.Kirstein@medizin.uni-leipzig.de">Anna.Kirstein@medizin.uni-leipzig.de</a><br /><br /><strong>Editorial Office</strong><br />Heike Jahnke, Berlin, Germany<br /><a href="mailto:heike.jahnke@degruyter.com">heike.jahnke@degruyter.com</a> </p> </div> </div> </div> </div> <div class="tab-pane mt-5 mb-4" id="latestIssue" role="tabpanel" aria-labelledby="latestIssueTab"> <h2 class="screen-reader">Latest issue</h2> <div class="row mt-3 me-4"> <div class="col-auto"> <h3>Volume 38 Issue 3</h3> </div> <div class="col-auto"> <div class="h3 text-muted latestIssuePubDate"> March 2025 </div> </div> </div> <div class="issueToc" data-containscitations="true"><div class="issueArticle unmatched"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2025-frontmatter3' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Publicly Available</span> <span class="pubDate ms-2 metadataInfoMainContent">March 3, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2025-frontmatter3" href="/document/doi/10.1515/jpem-2025-frontmatter3/html"> <h4 class="titleSearchPageResult mb-0">Frontmatter</h4> </a> </div> <div class="resultMetadata"> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: i-iii </span> </div> </div> </div> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="false" data-doi="10.1515/jpem-2025-frontmatter3"> <button id='citationsModalButton101515_jpem-2025-frontmatter3' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2025-frontmatter3' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2025-frontmatter3" aria-controls='citationsModal101515_jpem-2025-frontmatter3'> Cite this </button> <a href="/document/doi/10.1515/jpem-2025-frontmatter3/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2025-frontmatter3" title='Download PDF'> <span class="">Download PDF</span> </a> </div> <div class="collapse" id="details-0"> <div class="row"> <div class="abstract col"> </div> </div> </div> </div> </div><div class="issueSubjectGroup mb-4" id="issue-subject-group-originalarticles"><h3 class="issueSubjectGroupHeading">Original Articles</h3><div class="groupArticles pr-4"><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0464' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0464"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 6, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0464" href="/document/doi/10.1515/jpem-2024-0464/html"> <h4 class="titleSearchPageResult mb-0">Thyroid surgery in pediatric age: a 10-year experience at a single center and literature review</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Orhan Asya, Ali Cemal Yumusakhuylu, Yavuz Gundogdu, Omer Faruk Kuyumcu, Serap Turan, Tulay Guran, Busra Gurpinar Tosun, Cagatay Oysu</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 201-206 </span> </div> </div> </div> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0464"> <a href="#details-1" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-1" aria-expanded="false" aria-controls="details-1"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0464' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0464' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0464" aria-controls='citationsModal101515_jpem-2024-0464'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0464"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0464/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0464" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-1"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Surgery interventions for thyroid disorders are rare in pediatric population. This study aims to present our institution’s 10-year experience regarding the surgical treatment and outcomes of thyroid pathologies in children and review the literature. Methods All pediatric patients who underwent thyroid surgery at our institution from April 2013 to October 2023 were retrospectively reviewed. Results The study included 57 patients with a median age of 15 years. 38 patients (66.6 %) were female, and 19 patients (33.3 %) were male. The most common indication for thyroid surgery was a nodule (71.9 %), followed by Graves’ disease (10.5 %), multinodular goiter (8.7 %), and familial multiple endocrine neoplasia syndrome (8.7 %). Of the 57 patients, 36 (63.2 %) were diagnosed with thyroid neoplasia, with 28 (77.8 %) having papillary thyroid carcinoma (PTC), three (8.3 %) having medullary thyroid carcinoma (MTC), two (5.6 %) having follicular thyroid carcinoma (FTC). Temporary unilateral vocal cord paralysis and permanent unilateral vocal cord paralysis were seen in three patients (5.3 %) and in two patients (3.5 %) respectively. Persistent hypocalcemia and permanent hypoparathyroidism were noted in two patients (3.5 %), while transient hypocalcemia was observed in 13 patients (22.8 %). The presence of neoplasm did not appear to be associated with the incidence of hypocalcemia or vocal cord paralysis (p=0.115 and 0.652, respectively). Conclusions Thyroid pathologies in pediatric patients necessitate a multidisciplinary approach. Surgical management should be carefully evaluated in accordance with pediatric guidelines. Complication rate significantly decreases when surgery is performed by experienced surgeon. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0289' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0289"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">December 31, 2024</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0289" href="/document/doi/10.1515/jpem-2024-0289/html"> <h4 class="titleSearchPageResult mb-0">Differentiated thyroid cancer in adolescents – does extent of disease at presentation differ with age?</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Priya Arya, Emily A. Wright, Eric K. Shaw, Daniel J. Lubin, Kara K. Prickett</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 207-217 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0289" href="/document/doi/10.1515/jpem-2024-0289/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0289/asset/graphic/j_jpem-2024-0289_fig_001.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0289"> <a href="#details-2" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-2" aria-expanded="false" aria-controls="details-2"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0289' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0289' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0289" aria-controls='citationsModal101515_jpem-2024-0289'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0289"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0289/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0289" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-2"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives The authors sought to assess whether the age of 18 reflects a true pathological inflection point that justifies transitioning between pediatric and adult paradigms of care with differentiated thyroid cancer (DTC). Methods A retrospective chart review was conducted for patients aged 12–24 undergoing hemithyroidectomy or total thyroidectomy for papillary or follicular thyroid carcinoma from 2010 to 2020. Results A total of 153 patients receiving surgery for DTC were assessed for pathological stage, nodal metastasis, and thyroid neoplasm characteristics. When comparing pathologic tumor staging of patients <18 vs. ≥18 years old, there was a significant relationship between age and pT stage (p=0.009), but not between age and pN stage (p=0.319). However, when comparing patients ≤15 vs. >15 years, there was a significant relationship between age and pT stage (p=0.015) and age and pN stage (p=0.016). Patients ≤15 years of age most commonly had stage pT2 tumors (48.9 %, n=22), whereas most >15 years had stage pT1 tumors (37.9 %, n=41). Of patients whose lymph nodes were analyzed, patients ≤15 years were most likely to have pN1b disease (31.1 %, n=14), while patients >15 years were most likely to have pN0 disease (33.3 %, n=36). Conclusions In this sample, separating children and adults at an age of 15, rather than 18, yielded more significant differences in risk of nodal involvement. Markers of invasive histology were more common in patients older than 15, while nodal involvement was more common in patients 15 and under. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0566' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0566"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 17, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0566" href="/document/doi/10.1515/jpem-2024-0566/html"> <h4 class="titleSearchPageResult mb-0">Evaluation of iodine and selenium level and thyroid functions in patients with cystic fibrosis</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Edip Unal, Enes Arıca, Funda Feryal Taş, Barış Kolbaşı, Nurcan Beyazıt, İbrahim Kaplan, Suat Savaş, Velat Şen</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 218-223 </span> </div> </div> </div> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0566"> <a href="#details-3" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-3" aria-expanded="false" aria-controls="details-3"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0566' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0566' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0566" aria-controls='citationsModal101515_jpem-2024-0566'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0566"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0566/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0566" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-3"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives There is limited research on thyroid function in pediatric patients with cystic fibrosis (pwCF). This study aimed to determine the frequency of thyroid dysfunction in children and adolescents with CF and to evaluate iodine deficiency and selenium status in pwCF. Methods Sixty-two CF patients and 62 control subjects were evaluated. The anthropometric measurements, nutritional status, FEV1(Forced-expiratory-volume in 1 s) percentage, thyroid function tests (TSH, FT4, FT3), urinary iodine and selenium levels, hospitalization status in the last six months, antibiotic usage, and colonization status with staphylococcus or pseudomonas were assessed for the cases. Results The mean age of the patient group was 10.84 ± 4.04 years. All CF patients were receiving multivitamin supplementation. Malnutrition was present in 50 % of patients, bacterial colonization in 29 %, FEV1 decrease in 38.5 %, subclinical hypothyroidism (SH) in 12.9 %, iodine deficiency in 87 % and exocrine pancreatic insufficiency in 100 %. T3 levels were found to be higher in pwCF. No significant difference was found between malnutrition and FEV1 and urinary iodine and selenium levels. Compared to the control group, pwCF had lower urinary iodine levels. Conclusions To the best of our knowledge, our study is one of the few in the literature to investigate urinary selenium levels alongside iodine in PwCF. Further research is needed to clarify and interpret elevated urinary selenium levels in this context. It was shown that iodine deficiency and the rate of SH were relatively high in pwCF. However, it was still thought that correcting iodine deficiency in these patients could improve thyroid dysfunction associated with CF. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0070' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span class="fa fas fa-icon-open-access pe-1"></span><span class="accessOpenAccess">Open Access</span> <span class="pubDate ms-2 metadataInfoMainContent">January 16, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0070" href="/document/doi/10.1515/jpem-2024-0070/html"> <h4 class="titleSearchPageResult mb-0">Interpreting positive celiac serology in children with new-onset type 1 diabetes</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Lydia Ramharack, Colin P. Hawkes, Paige Coughlin, Lionola Juste, Sando Ojukwu, Steven M. Willi, Arunjot Singh</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 224-230 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0070" href="/document/doi/10.1515/jpem-2024-0070/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0070/asset/graphic/j_jpem-2024-0070_fig_002.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="false" data-doi="10.1515/jpem-2024-0070"> <a href="#details-4" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-4" aria-expanded="false" aria-controls="details-4"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0070' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0070' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0070" aria-controls='citationsModal101515_jpem-2024-0070'> Cite this </button> <a href="/document/doi/10.1515/jpem-2024-0070/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0070" title='Download PDF'> <span class="">Download PDF</span> </a> </div> <div class="collapse" id="details-4"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives The association of celiac disease (CD) in type 1 diabetes mellitus (T1DM) is well-established, yet variation exists in screening practices. This study measures the accuracy of early screening with tissue transglutaminase immunoglobulin A (TTG-IgA) and endomysial antibody (EMA) in newly diagnosed T1DM. Methods This is a retrospective study of children with T1DM between 2013 and 2019 with early CD screening and follow-up. Data elements included anthropometrics, serologies, blood pH, bicarbonate, and Hemoglobin A1c. Celiac serologies were analyzed using chi-square and receiver operating characteristic curves to calculate optimal levels for predicting CD. Results A total of 1,292 children met inclusion criteria with 142 having positive celiac serologies; 47 (33.1 %) of whom were subsequently diagnosed with CD – an incidence of 3.6 %. All subjects with positive EMA and TTG-IgA ≥8 times upper limit of normal were diagnosed with CD. Gastrointestinal symptoms, BMI, and thyroid disease were not statistically significant variables in this cohort, although there was a trend toward CD in lower BMI patients and higher TTG IgA in those with markedly elevated HgbA 1c . Conclusions Early celiac screening in T1DM is reliable and promotes timely CD diagnosis and treatment. Although transient positive celiac serologies were noted, the degree of TTG-IgA elevation and EMA positivity are strong predictors of coexisting CD. Larger prospective studies using these assays will further define the risk stratification algorithm that is needed for our T1DM community. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0627' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0627"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 21, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0627" href="/document/doi/10.1515/jpem-2024-0627/html"> <h4 class="titleSearchPageResult mb-0">Elastographic evaluation for fatty liver disease in north Indian children and adolescents with type 1 diabetes</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Vinod Gupta, Devi Dayal, Anmol Bhatia, Naresh Sachdeva, Sadhna Lal, Anju Bala, Savita Verma Attri</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 231-239 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0627" href="/document/doi/10.1515/jpem-2024-0627/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0627/asset/graphic/j_jpem-2024-0627_fig_003.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0627"> <a href="#details-5" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-5" aria-expanded="false" aria-controls="details-5"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0627' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0627' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0627" aria-controls='citationsModal101515_jpem-2024-0627'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0627"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0627/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0627" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-5"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives The prevalence and predisposing factors to metabolic dysfunction-associated fatty liver disease (MAFLD) in children with type 1 Diabetes (T1D) living in developing countries are unknown. Methods A cross-sectional study was conducted in children with T1D. The presence of liver fat and tissue stiffness were assessed by ultrasonography and shear-wave elastography (SWE), respectively. The SWE values were correlated to body mass index (BMI), glycemic control, disease duration, and gamma-glutamyl transferase (GGT). Healthy non-obese children (n=36) were recruited as controls. Results One hundred children with T1D were grouped (Group A-C) according to the disease duration (<5, 5–10, and >10 years, respectively). The mean diabetes duration and glycated hemoglobin were 5.9 ± 4.0 years and 8.2 ± 0.55 %, respectively. The mean SWE values were significantly higher in the patient groups compared to controls (5.07 ± 0.67, 5.27 ± 0.65, 5.16 ± 0.50, vs. 4.80 ± 0.82 kPa, p-value 0.006). The liver stiffness based on SWE showed a positive but weak relationship with BMI, diabetes duration, glycemic control, and GGT levels. A significantly higher number of children with T1D had MAFLD [9(20 %), 7(24.1 %), 7(26.9 %), vs. 1(3 %), p-value <0.001] based on ultrasonography. Conclusions Children with T1D showed higher liver stiffness values than controls. A weakly positive relationship of liver stiffness was observed with BMI, duration of diabetes, glycemic control, and serum GGT. Approximately one-fourth of children with diabetes showed sonographic evidence of hepatic steatosis. Larger studies are needed to ascertain the effects of obesity, diabetes duration, and metabolic control on the prevalence and progression of MAFLD in children with T1D. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0479' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0479"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 23, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0479" href="/document/doi/10.1515/jpem-2024-0479/html"> <h4 class="titleSearchPageResult mb-0">Diagnostic value of fasting insulin and insulin-like growth factor-1 levels in girls with central precocious puberty</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Hong-ru Zhang, Ya Xiao, Shu-qin Jiang, Jun Sun, Wen-hui Shi, Jin-bo Li, Wei Wang</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 240-247 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0479" href="/document/doi/10.1515/jpem-2024-0479/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0479/asset/graphic/j_jpem-2024-0479_fig_002.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0479"> <a href="#details-6" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-6" aria-expanded="false" aria-controls="details-6"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0479' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0479' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0479" aria-controls='citationsModal101515_jpem-2024-0479'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0479"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0479/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0479" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-6"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives The gonadotropin-releasing hormone (GnRH) provocation test is crucial for diagnosing central precocious puberty (CPP). However, due to its invasion and high cost, it is essential to find a simpler biomarker. This study aimed to investigate the feasibility of fasting insulin (FINS) and insulin-like growth factor-1 (IGF-1) as potential biomarkers for diagnosing girls with CPP and to analyze their effects on puberty development. Methods From May 2023 to June 2024, we retrospectively analyzed 145 girls in the growth clinic of the Third Affiliated Hospital of Zhengzhou University, including 80 CPP girls as the case group and 65 normal growth and development girls as the control group. Collect their growth and development parameters and blood samples. The levels of FINS, IGF-1, and sex hormones were detected and compared between the two groups. Results Compared with the control group, girls in the CPP group showed higher levels of FINS, IGF-1, and IGF-1 standard deviation score (IGF-1 SDS) (p<0.001). Multivariate logistic regression analysis showed that the risk of CPP increased with the increase of FINS, IGF-1, and IGF-1SDS levels [OR=1.141, 95 % CI=(1.029–1.265), p<0.05; OR=1.062, 95 % CI=(1.011–1.116), p<0.05; OR=1.610, 95 % CI=(1.029–2.520), p<0.05]. The areas under the curve of FINS, IGF-1, IGF-1SDS, and their combination in the diagnosis of CPP were 0.759, 0.716, 0.707, and 0.777, respectively. Conclusions Elevated FINS and IGF-1 levels in girls with CPP indicate their potential as effective biomarkers for early screening and diagnosis of CPP. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0496' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0496"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 23, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0496" href="/document/doi/10.1515/jpem-2024-0496/html"> <h4 class="titleSearchPageResult mb-0">Clinical outcomes of switching to lonapegsomatropin from somatropin for treatment of pediatric growth hormone deficiency</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Emma Coyne, Gajanthan Muthuvel, Iris Gutmark-Little</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 248-253 </span> </div> </div> </div> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0496"> <a href="#details-7" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-7" aria-expanded="false" aria-controls="details-7"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0496' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0496' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0496" aria-controls='citationsModal101515_jpem-2024-0496'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0496"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0496/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0496" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-7"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives This study aimed to assess differences in insulin-like growth factor 1 (IGF-1) levels following the transition from somatropin to lonapegsomatropin in patients with pediatric growth hormone deficiency (GHD). Secondary objectives included the evaluation of dose titrations based on IGF-1 levels, changes in annualized height velocity (AHV) and body mass index (BMI), and assessing reported adverse effects associated with lonapegsomatropin therapy. Methods A single-center, retrospective review was conducted including patients diagnosed with pediatric GHD initially treated with somatropin who transitioned to lonapegsomatropin between January 1, 2022, and December 31, 2023. Results Fourteen patients (median age: 9 years) were included. The median somatropin dose was 0.18 mg/kg/week (range, 0.09 to 0.29) at the time of transition and patients were initiated on a median lonapegsomatropin dose of 0.23 mg/kg/week (range, 0.15 to 0.26). This resulted in an IGF-1 increase of 2.3 SDS post-switch. Dose adjustments were made based on IGF-1 levels. Five patients required immediate dose reductions; four of these required further adjustments due to persistent elevation. There were no serious adverse effects reported. Conclusions Lonapegsomatropin may be a favorable option to reduce injection burden for those with pediatric GHD, though the manufacturer’s recommended starting dose of 0.24 mg/kg/week may require individualization. Careful monitoring and dose adjustment based on IGF-1 levels are necessary to maintain safety and efficacy. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0419' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span class="fa fas fa-icon-open-access pe-1"></span><span class="accessOpenAccess">Open Access</span> <span class="pubDate ms-2 metadataInfoMainContent">January 16, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0419" href="/document/doi/10.1515/jpem-2024-0419/html"> <h4 class="titleSearchPageResult mb-0">Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Manman Zhao, Guoshuang Feng, Bingyan Cao, Yannan Zheng, Chun-Xiu Gong</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 254-261 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0419" href="/document/doi/10.1515/jpem-2024-0419/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0419/asset/graphic/j_jpem-2024-0419_fig_002.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="false" data-doi="10.1515/jpem-2024-0419"> <a href="#details-8" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-8" aria-expanded="false" aria-controls="details-8"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0419' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0419' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0419" aria-controls='citationsModal101515_jpem-2024-0419'> Cite this </button> <a href="/document/doi/10.1515/jpem-2024-0419/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0419" title='Download PDF'> <span class="">Download PDF</span> </a> </div> <div class="collapse" id="details-8"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives To develop a clinical model for predicting the occurrence of Central Precocious Puberty based on the breast development outcomes in chinese girls. Methods This is a retrospective study, which included a total of 1,001 girls aged 6–9 years old who visited the outpatient clinic of Beijing Children’s Hospital from January 2017 to October 2022 for “breast development”. Participants were categorized into pubertal development (PD) cohort and simple premature breast development (PT) according to the criteria, and information was collected and tested for relevant indicators. After dealing with missing data, logistic regression, LASSO regression and random forest were used to screen the variables, and support vector machine models were built with SMOTE oversampling and ten-fold cross-validation to assess the effectiveness of the models in the training and validation sets. Results A total of 1,001 girls were included in the analysis, of whom 369 (36.9 %) were diagnosed with PD and 632 (63.1 %) with PT. Body mass index (BMI), bone age (BA), luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), uterine diameter, and ovary volume were identified as the final predictor variables by three variable screening methods. The AUC of the constructed disease diagnostic model was 0.9457 in the developmental cohort and 0.8357 in the external validation group, and sensitivity analyses revealed that the performance of the constructed models with different variable selection strategies was similar. Conclusions A disease diagnostic model was developed that may help predict a girl’s risk of diagnosing central precocious puberty. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0415' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0415"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 10, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0415" href="/document/doi/10.1515/jpem-2024-0415/html"> <h4 class="titleSearchPageResult mb-0">Adrenal hypoandrogenism in adolescents with premature ovarian insufficiency</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Meliha Esra Bilici, Zeynep Şıklar, Semra Çetinkaya, Elif Özsu, Zehra Aycan, Merih Berberoğlu</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 262-270 </span> </div> </div> </div> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0415"> <a href="#details-9" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-9" aria-expanded="false" aria-controls="details-9"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0415' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0415' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0415" aria-controls='citationsModal101515_jpem-2024-0415'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0415"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0415/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0415" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-9"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Premature ovarian insufficiency (POI) affects 1 in 10,000 children, with its molecular causes largely unknown. Adult studies suggest that low androgen levels induce ovarian insufficiency, but data on about this in children is limited. This study aims to assess the prevalence of low androgen levels in childhood POI and its relationship with adrenal insufficiency. Methods Idiopathic POI adolescents were categorized into two groups based on DHEAS and total testosterone (TT) measured by chemiluminescence. Low androgen group (LAG) was defined using cut-offs according to Tanner pubarche staging. Demographic, clinical, and laboratory data were compared. Morning cortisol <7 μg/dL and/or ACTH >96 or <5 pg/mL were planned to undergo ACTH stimulation testing, with a peak cortisol response <18 μg/dL considered insufficient. Results Forty-three adolescents, mean age 15.5 ± 1.3 years with a 46, XX karyotype, normal FMR1 mutation, FSH levels >40 mIU/mL, and low AMH levels were included. In 14 cases (37.8 %), DHEAS and TT were low. In the LAG, pubarche was absent in seven patients, and initial height SDS was significantly lower. Morning cortisol ranged from 7.9 to 23.5 μg/dL, with an ACTH of 29.4 ± 9.7 pg/mL. No differences in adrenal steroids or correlations between DHEAS and ACTH were observed. Conclusions Diminished androgen levels are prevalent in children with idiopathic POI. The potential for this condition to increase the risk of adrenal insufficiency and its impact on secondary ovarian insufficiency remains unclear. This study, the first of its kind in children, underscores the potential role of genetic factors in zona reticularis and ovarian development. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0335' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0335"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 16, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0335" href="/document/doi/10.1515/jpem-2024-0335/html"> <h4 class="titleSearchPageResult mb-0">The clinical presentation and genetic diagnosis of Tangier disease in the pediatric age group</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Selcan Öztürk, Muhammet Ensar Doğan, Banu Kadıoğlu Yılmaz, Ayten Güleç, Pembe Soylu Üstkoyuncu, Fatih Kardaş, Hakan Gümüş, Hüseyin Per</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 271-278 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0335" href="/document/doi/10.1515/jpem-2024-0335/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0335/asset/graphic/j_jpem-2024-0335_fig_001.jpg graphic/j_jpem-2024-0335_fig_002.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0335"> <a href="#details-10" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-10" aria-expanded="false" aria-controls="details-10"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0335' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0335' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0335" aria-controls='citationsModal101515_jpem-2024-0335'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0335"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0335/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0335" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-10"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Tangier disease (TD) is a rare autosomal recessive condition characterized by high-density lipoprotein (HDL) deficiency; involving symptoms of polyneuropathy, hyperplastic orange-yellow tonsils, vision disorder, and sudden cardiac death. The major clinical symptoms of TD may not all be co-present. This study evaluates patients diagnosed with TD in childhood to improve the possibility of early diagnosis of asymptomatic cases by reporting our patients’ clinical characteristics in order to minimize delayed diagnosis and emphasize the importance of TD, easily detected by HDL measurement. Methods This retrospective and cross-sectional study investigated seven patients from three different families diagnosed with TD. Results Four of seven patients were girls. Median age was 5.7 years at symptom onset and 6.5 years at diagnosis. The index case presented with neuropathy findings, and TD was diagnosed based on genetic analysis. Low lipid levels were determined in a sibling and cousins with cardiac death and gait disturbance in the family. TD was confirmed by genetic investigation. Our other patients were evaluated due to anemia, thrombocytopenia, yellow-orange hypertrophy in the tonsils, and organomegaly. Diagnosis was established with genetic analysis and low HDL. No coronary artery disease or ocular involvement was observed in any case. Conclusions All patients presenting with neuropathy and gait disorders should undergo detailed tonsil examinations and HDL tests. Genetic analysis should be carried out if necessary. Family screening should be recommended to patients with consanguineous marriages after diagnosis of TD. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0352' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0352"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 21, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0352" href="/document/doi/10.1515/jpem-2024-0352/html"> <h4 class="titleSearchPageResult mb-0">Clinical and genetic diagnosis of first cohort of differences of sexual development in the Iranian population</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Mandana Rastari, Masomeh Askari, Kenneth McElreavey, Anu Bashamboo, Zeinab Rokhsattalab, Maryam Razzaghy-Azar, Mahdieh Bakhshi, Mehdi Totonchi</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 279-287 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0352" href="/document/doi/10.1515/jpem-2024-0352/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0352/asset/graphic/j_jpem-2024-0352_fig_001.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0352"> <a href="#details-11" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-11" aria-expanded="false" aria-controls="details-11"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0352' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0352' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0352" aria-controls='citationsModal101515_jpem-2024-0352'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0352"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0352/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0352" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-11"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Differences of sex development (DSD) refer to various congenital conditions affecting the urogenital and hormonal systems. Accurate diagnosis and personalized management are crucial for supporting patients through complex decisions, such as those related to gender identity. Methods This study represents the first comprehensive investigation into DSD in Iran, analyzing patient’s clinical and genetic data between 1991 and 2020. Karyotype analysis was performed on 69 patients without a molecular diagnosis, with sex chromosome DSD excluded. Presence of SRY gene evaluated in all sex reversal patients. Whole exome sequencing (WES) was used for 26 undiagnosed patients, revealing pathogenic variants in WT1 , NR5A1 , DHX37 , AR , CYP17A1 , and LHCGR genes. Results The most common diagnosis was testicular TDSD, identified in 42 patients (60.86 %), with the SRY gene being the primary cause in 36 of these patients. The study highlights the importance of genetic analysis in identifying novel and rare gene variants, particularly within the steroid hormone and gonad differentiation pathways, for both 46, XY and 46, XX DSD. Conclusions These findings emphasize the need for genetic analysis in providing personalized patient care and tailored counseling to help individuals navigate complex decisions, including those involving gender identity. </div> </div> </div> </div> </div> </div></div><div class="issueNestedSubjectGroup ms-4"></div></div><div class="issueSubjectGroup mb-4" id="issue-subject-group-shortcommunication"><h3 class="issueSubjectGroupHeading">Short Communication</h3><div class="groupArticles pr-4"><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0606' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span class="fa fas fa-icon-open-access pe-1"></span><span class="accessOpenAccess">Open Access</span> <span class="pubDate ms-2 metadataInfoMainContent">January 24, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0606" href="/document/doi/10.1515/jpem-2024-0606/html"> <h4 class="titleSearchPageResult mb-0">Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Maria Rodanaki, Eva Rask, Maria Lodefalk</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 288-291 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0606" href="/document/doi/10.1515/jpem-2024-0606/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0606/asset/graphic/j_jpem-2024-0606_fig_001.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="false" data-doi="10.1515/jpem-2024-0606"> <a href="#details-12" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-12" aria-expanded="false" aria-controls="details-12"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0606' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0606' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0606" aria-controls='citationsModal101515_jpem-2024-0606'> Cite this </button> <a href="/document/doi/10.1515/jpem-2024-0606/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0606" title='Download PDF'> <span class="">Download PDF</span> </a> </div> <div class="collapse" id="details-12"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Kisspeptin plays a major role in the onset of puberty by stimulating the gonadotropin-releasing hormone (GnRH) neurons. The aim of this study was to investigate whether GnRH inhibits kisspeptin secretion via a negative feedback mechanism and potential associations between kisspeptin levels and other hormones of importance for pubertal onset. Methods Thirteen girls with suspected central precocious puberty underwent a GnRH stimulation test twice in a randomized, placebo-controlled manner. Blood was sampled up to 150 min after an IV injection of either Relefact LHRH ® or saline. The levels of kisspeptin, acylated ghrelin, ultrasensitive oestradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), insulin and glucose were analysed. Results Baseline kisspeptin levels ranged from 9.9 to 201.6 pg/mL. Neither area under the curve for kisspeptin levels nor peaks were significantly lower after the GnRH injection compared to placebo. Baseline kisspeptin and glucose levels tended to be associated (rho=0.55, p=0.051) but no other associations were found between kisspeptin and other hormones. Conclusions Basal levels of kisspeptin vary widely in young girls. We found no evidence of a negative feedback mechanism of GnRH on kisspeptin in this small pilot study. The suggested association between kisspeptin and glucose levels needs further investigations. </div> </div> </div> </div> </div> </div></div><div class="issueNestedSubjectGroup ms-4"></div></div><div class="issueSubjectGroup mb-4" id="issue-subject-group-casereports"><h3 class="issueSubjectGroupHeading">Case Reports</h3><div class="groupArticles pr-4"><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0378' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0378"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 10, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0378" href="/document/doi/10.1515/jpem-2024-0378/html"> <h4 class="titleSearchPageResult mb-0">Coexistence of phenylketonuria and tyrosinemia type 3: challenges in the dietary management</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Arzu Selamioğlu, Tuğba Kozanoğlu, İlknur Hacıoğlu, Mehmet Cihan Balcı, Meryem Karaca, Asuman Gedikbaşı, Bülent Uyanık, Gülden Gökçay</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 292-298 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0378" href="/document/doi/10.1515/jpem-2024-0378/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0378/asset/graphic/j_jpem-2024-0378_fig_001.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0378"> <a href="#details-13" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-13" aria-expanded="false" aria-controls="details-13"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0378' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0378' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0378" aria-controls='citationsModal101515_jpem-2024-0378'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0378"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0378/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0378" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-13"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Phenylketonuria (PKU) and tyrosinemia type 3 (HT3) are both rare autosomal recessive disorders of phenylalanine-tyrosine metabolism. PKU is caused by a deficiency in phenylalanine hydroxylase (PAH), leading to elevated phenylalanine (Phe) and reduced tyrosine (Tyr) levels. HT3, the rarest form of tyrosinemia, is due to a deficiency in 4-hydroxyphenylpyruvate dioxygenase (HPD). Case presentation We report a 5-year-old girl diagnosed with both PKU and HT3. She presented with elevated Phe levels in neonatal screening, and subsequent biochemical tests revealed both hyperphenylalaninemia and elevated Tyr levels. Genetic analysis confirmed the diagnoses, identifying homozygous mutations in both the PAH and HPD genes. Dietary management to maintain optimal Phe and Tyr levels proved to be challenging due to the presence of these two coexisting pathologies especially during infections and due to dietary non-compliance, necessitating frequent adjustments in the treatment strategy. Conclusions This case highlights the importance of considering multiple metabolic disorders in patients with unexplained clinical and biochemical findings. Early diagnosis and stringent dietary management are crucial for preventing neurological damage and ensuring favorable outcomes in patients with concurrent metabolic disorders. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0542' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0542"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 7, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0542" href="/document/doi/10.1515/jpem-2024-0542/html"> <h4 class="titleSearchPageResult mb-0">Acrodermatitis dysmetabolica: lessons from two pediatric cases</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Ayça Burcu Kahraman, Meryem Sıla Cosar, Ekrem Eren Dogan, Yaşar Ünlü, Cuneyt Ugur, Zafer Bagcı</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 299-304 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0542" href="/document/doi/10.1515/jpem-2024-0542/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0542/asset/graphic/j_jpem-2024-0542_fig_003.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0542"> <a href="#details-14" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-14" aria-expanded="false" aria-controls="details-14"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0542' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0542' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0542" aria-controls='citationsModal101515_jpem-2024-0542'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0542"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0542/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0542" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-14"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency. Case presentation This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention. Conclusions These cases emphasize the importance of identifying AD in IMDs and the critical need for meticulous monitoring of amino acid levels, as deficiencies may lead to severe complications. </div> </div> </div> </div> </div> </div><div class="border-bottom" style="height: 1px"></div><div class="issueArticle"> <div class="modal" id='citationsModal101515_jpem-2024-0506' tabindex="-1" role="dialog" aria-label='Cite this' data-retrievedfordoi="" aria-hidden="true"> <div class="d-none" id="citationsModalError" hidden="hidden" aria-hidden="true">Unable to retrieve citations for this document</div> <div class="modal-dialog modal-dialog-centered modal-xl" role="document"> <div class="modal-content bg-white"> <div class="modal-body"> <button type="button" class="btn-close float-end btn-modal-close" data-bs-dismiss="modal" aria-label='Close'> </button> <div class="d-flex justify-content-center"> <div class="spinner-border me-3" role="status" id="citationsModalSpinner" aria-hidden="true"> </div> Retrieving citations for document... </div> </div> </div> </div> </div> <div class='searchResult py-3'> <div class="searchResultContent w-100 issueEntry"> <div class="text-container"> <div> <span data-availabilitydoi="10.1515/jpem-2024-0506"> <span class="notAvailable d-none"> <span class="d-none notAuthUserLoggedOut"> <span class="fa fas fa-icon-not-authorized pe-1"></span> <span class="accessRequireAuth">Requires Authentication</span> </span> <span class="d-none notAuthUserLoggedIn"> <span class="fa fas fa-icon-not-authorized"></span> <span class="accessRequireAuth">Unlicensed</span> </span> </span> <span class="contentAvailable d-none"><span class="fa fas fa-icon-authorized pe-1"></span><span class="accessAccessible">Licensed</span></span> </span> <span class="pubDate ms-2 metadataInfoMainContent">January 1, 2025</span> <div class="resultTitle"> <a class="issueContentsArticleLink linkHoverDark d-inline-block" data-doi="10.1515/jpem-2024-0506" href="/document/doi/10.1515/jpem-2024-0506/html"> <h4 class="titleSearchPageResult mb-0">Dramatic response to Evinacumab in a North Indian girl with homozygous familial hypercholesterolemia</h4> </a> </div> <div class="resultMetadata"> <div class="contributors me-2 metadataAndContributorsFont">Sonali Arora, Sayan Banerjee, Arun George, Anju Bala, Shyam Kumar Singh Thingnam, Manoj Kumar Rohit, Devi Dayal</div> <div> <span class="pageRange me-2 metadataAndContributorsFont"> Page range: 305-309 </span> </div> </div> </div> </div> <div class="teaser-image"> <a data-doi="10.1515/jpem-2024-0506" href="/document/doi/10.1515/jpem-2024-0506/html"> <img alt='Teaser image from the article' loading="lazy" src=/document/doi/10.1515/jpem-2024-0506/asset/graphic/j_jpem-2024-0506_fig_001.jpg /> </a> </div> </div> <div class="searchResultActions mt-1 d-flex" data-batch-number="1" data-showaccessindicator="true" data-doi="10.1515/jpem-2024-0506"> <a href="#details-15" class="btn btn-main-content me-2" data-bs-toggle="collapse" data-bs-target="#details-15" aria-expanded="false" aria-controls="details-15"> More <span class="fa fas fa-down-dir"></span> </a> <button id='citationsModalButton101515_jpem-2024-0506' type="button" class="btn btn-main-content ga_cite_this me-2" href='#citationsModal101515_jpem-2024-0506' data-bs-toggle="modal" data-bs-target="[id^=citationsModal]" data-doi="10.1515/jpem-2024-0506" aria-controls='citationsModal101515_jpem-2024-0506'> Cite this </button> <span data-availabilitydoi="10.1515/jpem-2024-0506"> <span class="contentAvailable d-none"> <a href="/document/doi/10.1515/jpem-2024-0506/pdf" class="downloadPdf btn btn-main-content me-2 vgwort-click " data-doi="10.1515/jpem-2024-0506" title='Download PDF'> <span class="">Download PDF</span> </a> </span> </span> </div> <div class="collapse" id="details-15"> <div class="row"> <div class="abstract col"> <h3>Abstract</h3> <div class="abstractContent"> Objectives Homozygous familial hypercholesterolemia (HoFH) is a rare inherited disorder of lipoprotein metabolism associated with significant morbidity and early mortality. The conventional management with lipid-lowering drugs and lipoprotein apheresis is unable to consistently achieve guidelines recommended low-density lipoprotein cholesterol (LDL-C). We aim to describe the efficacy of Evinacumab, a recently approved monoclonal antibody, in lowering LDL-C in an Indian girl with HoFH. Case presentation A 16-year-old girl was diagnosed with HoFH at age two years after the appearance of cutaneous and tendo-calcaneus xanthomas. Genetic testing revealed a pathogenic homozygous deletion in the LDL receptor (LDLR) gene. Despite lifestyle measures, a low-fat diet, and maximum doses of atorvastatin and ezetimibe, her average LDL-C level remained 320.3 mg/dL over the past decade. Her caregivers did not accept LDL-apheresis. She also did not respond to Evolocumab therapy. The patient developed progressive calcific aortic stenosis and concentric left ventricular hypertrophy, necessitating aortic valve replacement surgery at age 16 years. The recent addition of Evinacumab to her lipid-lowering drug regimen, resulted in a significant LDL-C reduction of 76.16 %, bringing levels down to 82 mg/dL. These levels were sustained over the last four months. Conclusions Evinacumab offers a promising option for managing high-risk and difficult-to-treat HoFH patients. This is the first Indian child receiving Evinacumab for HoFH. </div> </div> </div> </div> </div> </div></div><div class="issueNestedSubjectGroup ms-4"></div></div></div> </div> </div> </nav> <div class="translationLink"> <a href="/journal/key/jpem/html?lang=de">(Deutsch)</a> </div> </div> </div> </div> <div class="col-lg-3 sidebar bg-light"> <div class="py-5 px-4"> <div class="mb-5"> <a href="/journal/key/jpem/38/3/html" class="btn btn-primary fw-bold py-2 w-100"> View latest issue </a> </div> <div class="accessBroughtToYouBy" data-idtype="journal_key" data-id="JPEM"></div> <div><current-price journalkey="JPEM"></current-price></div> <div class="details border-bottom" id="metadata"> <ul class="list-unstyled mb-4"> <li class="issn onlineIssn"> <span class="subTitleProductPage">Online ISSN:</span> <span class="subTitleInfoProductPage">2191-0251</span> </li> <li class="issn printIssn"> <span class="subTitleProductPage">Print ISSN:</span> <span 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