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Beyond the labelling: Expert medication resources are essential for safe and effective patient care | Wolters Kluwer

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aria-hidden="true" class="wk-icon-chevron-down ow-nav-level-1-chevron"></span></button> <div class="ow-primary-nav-level-2 "> <span class="primary-nav-overlay-desktop"></span> <div class="ow-primary-nav-level-2-wrapper ow-background-fill"> <div class="ow-background-fill-container"> <div class="ow-background-fill-region ow-background-fill-left"></div> <div class="ow-background-fill-region ow-background-fill-right"></div> <div class="ow-primary-nav-level-2-container ow-primary-nav-container"> <div class="ow-primary-nav-group"> <div class="ow-primary-nav-summary"> <div class="ow-primary-nav-content"> <h5 class="ow-nav-level-2-list-heading">Health</h5> <p class="ow-nav-level-2-copy">Trusted clinical technology and evidence-based solutions that drive effective decision-making and outcomes across healthcare. Specialized in clinical effectiveness, learning, research and safety.</p> <a href="/en-gb/health" class="ow-nav-level-2-view-all-link"><span>Health Overview</span><span aria-hidden="true" class="wk-icon-arrow-right"></span></a> </div> </div> <div class="ow-primary-nav-items"> <div class="ow-primary-nav-item"> <div class="ow-primary-nav-content"> <h6 class="ow-nav-level-2-list-heading">Solutions</h6> <ul class="ow-nav-level-2-list "> <li class="ow-nav-level-2-list-item ow-nav-level-2-list-item-with-text"><a href="/en-gb/solutions/uptodate" class="ow-nav-level-2-link">UpToDate</a><span class="ow-nav-level-2-text">Industry-leading clinical decision support</span></li> <li class="ow-nav-level-2-list-item ow-nav-level-2-list-item-with-text"><a href="/en-gb/solutions/ovid" class="ow-nav-level-2-link">Ovid</a><span class="ow-nav-level-2-text">The world’s most trusted medical research platform</span></li> <li class="ow-nav-level-2-list-item ow-nav-level-2-list-item-with-text"><a href="/en-gb/solutions/uptodate" class="ow-nav-level-2-link">UpToDate Lexidrug</a><span class="ow-nav-level-2-text">Evidence-based drug referential solutions</span></li> <li class="ow-nav-level-2-list-item ow-nav-level-2-list-item-with-text"><a href="/en-gb/solutions/ovid/ovid-synthesis" class="ow-nav-level-2-link">Ovid Synthesis</a><span class="ow-nav-level-2-text">Workflow solution for clinical practice improvements</span></li> </ul> <a href="/en-gb/health/our-solutions" class="ow-nav-level-2-view-all-link"><span>View All Solutions</span><span aria-hidden="true" class="wk-icon-arrow-right"></span></a> </div> </div> <div class="ow-primary-nav-item"> <div class="ow-primary-nav-content"> <h6 class="ow-nav-level-2-list-heading">Expert Insights</h6> <ul class="ow-nav-level-2-list "> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/expert-medication-resources-essential-for-safe-effective-patient-care" class="ow-nav-level-2-link">Beyond the labelling: Expert medication resources are essential for safe and effective patient care</a></li> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/the-hpv-vaccine-a-powerful-tool-in-cancer-prevention" class="ow-nav-level-2-link">The HPV vaccine: A powerful tool in cancer prevention</a></li> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/donated-mobile-cds-helps-ugandan-students-improve-study-patient-care" class="ow-nav-level-2-link">Donated mobile CDS subscriptions help Ugandan students improve study and patient care</a></li> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/post-covid-uk-hospital-uses-uptodate-to-refocus-on-doctor-training-and-health-equity" class="ow-nav-level-2-link">Post-COVID, UK hospital uses UpToDate to refocus on doctor training and health equity</a></li> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/three-pillars-of-healthcare-technology-predictions-in-2023" class="ow-nav-level-2-link">Three pillars of healthcare technology predictions in 2023</a></li> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/developing-clinical-empathy-to-improve-health-equity" class="ow-nav-level-2-link">Developing clinical empathy to improve health equity</a></li> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/six-challenges-to-delivering-quality-healthcare" class="ow-nav-level-2-link">Six challenges to delivering quality healthcare</a></li> <li class="ow-nav-level-2-list-item"><a href="/en-gb/expert-insights/providing-access-to-evidence-based-clinical-decision-support-by-sea" class="ow-nav-level-2-link">Providing access to evidence-based clinical decision support by land – and by sea</a></li> </ul> <a href="/en-gb/expert-insights/health" class="ow-nav-level-2-view-all-link"><span>View All Expert Insights</span><span aria-hidden="true" class="wk-icon-arrow-right"></span></a> </div> </div> </div> </div> </div> </div> </div> </div> </li> <li class="ow-nav-level-1-item"> <button type="button" class="wk-button wk-button-text ow-nav-level-1-trigger"><span class="ow-nav-level-1-trigger-text">Tax &amp; Accounting</span><span aria-hidden="true" class="wk-icon-chevron-down ow-nav-level-1-chevron"></span></button> <div class="ow-primary-nav-level-2 "> <span class="primary-nav-overlay-desktop"></span> <div class="ow-primary-nav-level-2-wrapper ow-background-fill"> <div class="ow-background-fill-container"> <div class="ow-background-fill-region ow-background-fill-left"></div> <div class="ow-background-fill-region ow-background-fill-right"></div> <div class="ow-primary-nav-level-2-container ow-primary-nav-container"> <div class="ow-primary-nav-group"> <div class="ow-primary-nav-summary"> <div class="ow-primary-nav-content"> <h5 class="ow-nav-level-2-list-heading">Tax &amp; Accounting</h5> <p class="ow-nav-level-2-copy">Enabling tax and accounting professionals and businesses of all sizes drive productivity, navigate change, and deliver better outcomes. 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class="ow-nav-level-1-item"> <button type="button" class="wk-button wk-button-text ow-nav-level-1-trigger"><span class="ow-nav-level-1-trigger-text">ESG</span><span aria-hidden="true" class="wk-icon-chevron-down ow-nav-level-1-chevron"></span></button> <div class="ow-primary-nav-level-2 "> <span class="primary-nav-overlay-desktop"></span> <div class="ow-primary-nav-level-2-wrapper ow-background-fill"> <div class="ow-background-fill-container"> <div class="ow-background-fill-region ow-background-fill-left"></div> <div class="ow-background-fill-region ow-background-fill-right"></div> <div class="ow-primary-nav-level-2-container ow-primary-nav-container"> <div class="ow-primary-nav-group"> <div class="ow-primary-nav-summary"> <div class="ow-primary-nav-content"> <h5 class="ow-nav-level-2-list-heading">ESG</h5> <p class="ow-nav-level-2-copy">Offering comprehensive tools and expert guidance to companies to help meet regulatory requirements to support sustainability efforts and manage ESG 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2024</span></div><h1 class="title field-title">Beyond the labelling: Expert medication resources are essential for safe and effective patient care</h1><div class="author-section"><span>By:</span><span class="author-link field-author-name" data-dm-wk="newsheader.link"><a title="jordan-fulcher" href="/en-gb/experts/jordan-fulcher">Jordan Fulcher, MPharm</a></span></div></div></div> </div> </div> <div class="row component column-splitter"> <div class="col-12 col-md-8 col-lg-1 sticky-wrapper"> <div class="row"> <div class="component social-share vertical col-12"> <div class="component-content"> <div class="share-sticky"><div class="share-wrapper"><div class="share-btn share-btn-linkedin" aria-label="Share on Linkedin"></div><div class="share-btn share-btn-twitter" aria-label=" Share on Twitter"></div><div class="share-btn share-btn-facebook" aria-label="Share on Facebook"></div><div class="share-btn share-btn-mail" aria-label="Share with Mail"></div><div class="share-btn share-btn-print" 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<div > <div class="row"> <div class="component rich-text article-text indent-top"> <div class="component-content"> <p class="abstract">Drug manufacturer labels and national formularies are often too limited in scope and depth to provide the patient-specific recommendations clinicians need to avoid adverse reactions.</p><h2>The evolving landscape of medicine</h2><p>As clinicians, we know that the field of medicine is a constantly evolving landscape, with new research emerging daily that enhances our understanding of diseases and expands the arsenal of drugs available to treat them.</p><p>For those on the front lines of patient care, this becomes even more challenging. Balancing the need for safe and effective treatment with the unique circumstances of individual patients and the limitations of existing resources is an issue that clinicians are dealing with around the world.</p><h2>The foundation of safe prescribing: licensing and labelling</h2><p>The foundation of safe prescribing lies in the licensing and labelling of medications. These regulations ensure that medications are rigorously tested and proven effective for their intended uses. However, the focus of this information is often on the broad strokes of regulatory approval, leaving out the finer details and nuances that are crucial for clinical decision-making. Regulatory approval and labelling primarily focus on approved uses, dosages, and safety warnings, which may not capture the dynamic nature of medical research. Emerging evidence on a drug’s effectiveness for off-label uses remains largely absent. Additionally, the latest prescribing strategies developed through real-world clinical experience may not be reflected in these documents, leaving clinicians out of the loop on potentially life-saving advancements.</p><h3>The limitations of current resources for clinicians</h3><p>National formularies, which are commonly relied upon by clinicians for prescribing information, frequently draw heavily from these licensing documents. While they provide essential general information about a medication, they fall short in several key areas.</p><ul><li><strong>Limited scope of information: </strong>The information available in formularies and labels often adheres to a one-size-fits-all approach. Labels cater to a broad audience, offering a simplified version of a drug’s interaction with the human body. However, each patient is unique. Factors such as age, weight, existing health conditions, and genetic makeup can significantly impact how a drug behaves within an individual. Limited information can lead to dosage miscalculations, increasing the risk of a medication being, at best, ineffective. At worse, it could cause adverse reactions and patient harm.</li><li><strong>Lack of depth and breadth:</strong> Manufacturer labelling often prioritizes brevity, omitting detailed information on a drug’s mechanism of action, potential side effects at different dosages, or how the drug interacts with specific foods or supplements. This lack of depth hinders a clinician’s ability to fully understand a medication’s intricacies. Without a thorough understanding of how a drug works, potential side effects may be difficult to anticipate or manage. Similarly, omitting details on the severity and prevalence of adverse reactions at various dosages makes it harder to discuss potential downsides with patients and make truly informed decisions together.</li><li><strong>Drug interactions and adverse reactions:</strong> A medication prescribed for one condition might interact poorly with another drug or supplement a patient is taking for a different indication, leading to reduced effectiveness or serious health complications. Whilst labelling and formularies often provide concise lists of interactions, there is a lack of actionable recommendations. Limited information on potential interactions makes it challenging for clinicians to identify these risks and manage them, potentially jeopardizing patient safety.</li></ul><p>These limitations highlight a clear need: The current resources available to clinicians are insufficient for navigating the complexities of modern medicine. A high-quality,<a href="/en-gb/solutions/uptodate/drug-decision-support"> evidence-based solution</a> is needed to empower clinicians to diagnose effectively, prescribe medications with greater precision, and ultimately deliver superior patient care.</p> </div> </div> </div> </div> </div> <div class="container-fluid"> <div > <div class="row"> <div class="component rich-text article-text col-12"> <div class="component-content"> <h2>The impact of comprehensive resources on patient care</h2><p>More comprehensive resources that seamlessly integrate the latest research findings, such as <a href="/en-gb/solutions/uptodate/enterprise/lexidrug">UpToDate® Lexidrug™</a> drug reference solution and <a href="/en-gb/solutions/medi-span/medi-span-around-the-world">Medi-Span®</a> embedded drug data, enable clinicians to stay informed about the most recent, evidence-based prescribing strategies. These resources provide <a href="/en-gb/expert-insights/why-its-important-to-adjust-drug-dosing-for-patient-specific-factors">patient-specific guidance</a>, considering a patient’s medical history, potential drug interactions, and even down to their <a href="/en-gb/expert-insights/pharmacogenomics-balancing-optimism-challenges">genetic variations</a>. This level of personalized information would significantly reduce the risk of adverse reactions and optimize treatment effectiveness. Providing clinicians access to detailed information allows them to identify and anticipate potential side effects and manage them proactively.</p><p>A trusted solution partner backed by trusted evidence and a <a href="/en-gb/solutions/uptodate/about/editorial-process">rigorous editorial review process</a> will not only highlights potential issues with prescriptions and treatments but will also provide clinicians with a clear action plan on how to manage these situations. One clinical resource that covers all stages of the medication process – from diagnosing, to prescribing, to administration and onto monitoring and management – aligns clinicians and clinical teams, providing all with the consistent access to the information that they need, at the right time, and allowing them to find guidance specific to the patient that they are treating.</p><h2>Streamlining medication prescribing, administration, and monitoring</h2><p>How could a more personalized medication decision support solution work for you and your clinical teams in the real world?</p><h3>Step 1: prescribing</h3><p>Let’s consider the following clinical situation: An elderly patient with a background of epilepsy has been diagnosed with hospital-acquired aspiration pneumonia. The usual local hospital guidelines recommend meropenem for this indication, but how do we adjust this for our specific patient at the <strong>prescribing</strong> stage? Firstly, we consider:</p><ul><li>Do they have any <a href="/en-gb/solutions/sentri7-clinical-surveillance/medication-management">renal impairment</a> associated with their advanced age?</li><li>Is their infection susceptible to meropenem, and how would we test for that?</li><li>What medicines are they taking for their epilepsy that could interact with the treatment?</li></ul><p>In this case, the labelling states that the use of meropenem with valproic acid and its derivatives are not recommended, but no practical information is provided to the clinician on how this should be managed in practice. What alternatives can be given?</p><h3>Step 2: verification</h3><p>Once a prescribing decision has been safely made, the pharmacist has additional considerations prior to <strong>verification</strong>.</p><ul><li>How should the treatment be monitored?</li><li>When should this be reviewed?</li><li>How do we step the patient down?</li></ul><h3>Step 3: administration</h3><p>Even when the medication is verified and ready to be administered, the nursing team will have additional questions that need to be answered to ensure safe <strong>administration</strong>.</p><ul><li>What infusion options do I have for this treatment?</li><li>Can I safely administer this <a href="/en-gb/expert-insights/iv-compatibility-challenges-best-practices-and-the-route-ahead">IV medication</a> alongside the others prescribed for my patient, or will I need to set up a new line?</li><li>Is there any administration-associated reactions that I need to be aware of?</li></ul><p>Without a trusted solution, these various clinicians can end up working from disparate resources, with varying degrees of accuracy. Resources such as UpToDate®, UpToDate Lexidrug, and Medi-Span align the highest-quality evidence with patient management recommendations. All members of the care team have access to the answers that they need, in one place.</p> </div> </div> <div class="component rich-text article-text col-12"> <div class="component-content"> <h2>The role of trusted resources in medication management</h2><p>The current information provided by labelling and national formularies is not enough for modern medicine. The limitations of existing resources force clinicians to balance adhering to regulations with providing the best possible care for their patients. A more comprehensive solution that integrates the latest research, offers patient-specific guidance, and provides in-depth drug information is essential. Empowering clinicians with such a tool would not only streamline the prescribing process but also lead to safer, more effective, and ultimately better patient care.</p><p>Learn more about Wolters Kluwer <a href="/en-gb/solutions/uptodate/drug-decision-support">medication decision support solutions</a>.</p> </div> </div> <div class="component wkbutton primary col-12 indent-bottom"> <div class="component-content"> <div class="wkbutton-link field-link"><a data-variantfieldname="Link" aria-label="Learn More" title="Learn more" href="/en-gb/solutions/uptodate/drug-decision-support" data-variantitemid="{7F4632FA-7D1B-4DCB-94D5-BF0C11B8F6B4}">Learn more</a></div><div class="wkbutton-wrapper"><div class="wkbutton-label field-label">Learn More</div></div> </div> </div> </div> </div> </div> <div class="container-fluid"> <div > <div class="row"> <div class="component author-bio author-bio col-12"> <div class="component-content"> <div class="author-header"><div class="author-image field-author-image"><image width="640" height="960" alt="Jordan Fulcher headshot" src="https://assets.contenthub.wolterskluwer.com/api/public/content/2401261-jordan-fulcher-headshot-21746aeefa?v=6956fd13" stylelabs-content-id="2401261" stylelabs-content-type="Image" thumbnailsrc="https://contenthub.wolterskluwer.com/api/gateway/2401261/thumbnail" data-variantitemid="{344E09A8-1EC5-4ECC-91BE-E0EFD1E22068}" format="" data-variantfieldname="Author Image" /></div><div class="author-info"><div class="author-name field-author-name" data-dm-wk="authorbio.link"><a title="jordan-fulcher" href="/en-gb/experts/jordan-fulcher">Jordan Fulcher, MPharm</a></div><div class="author-title field-author-title">Clinical pharmacist and clinical solution consultant for the EMEA region at Wolters Kluwer, Health</div></div></div><div class="author-description field-author-description">Jordan Fulcher is a clinical pharmacist and clinical solution consultant for the EMEA region at Wolters Kluwer Health. He also provides clinical pharmacy support to acute admissions wards and emergency departments of Norfolk and Norwich University Hospitals NHS Foundation Trust as a bank pharmacist.</div> </div> </div> </div> </div> </div> <div class="container-fluid"> <div > <div class="row"></div> </div> </div> </div></div> </div> <div class="col-12 col-md-4 col-lg-3 offset-lg-1 sticky-sidebar"> <div class="row"> <div class="component row-splitter"> <div class="container-fluid"> <div > <div class="row"> <div class="component relatedtopics col-12 compact"> <div class="component-content"> <div class="relatedtopics-wrapper"><h4 class="relatedtopics-header">Explore related topics</h4><div class="tag-list" role="list"><span class="field-title" role="listitem" ><a href="/en-gb/search-results/topic/care-variability">Care variability</a></span><span class="field-title" role="listitem" ><a href="/en-gb/search-results/topic/empowering-the-workforce">Empowering the workforce</a></span><span class="field-title" role="listitem" ><a href="/en-gb/search-results/topic/enterprise-software">Enterprise software</a></span><span class="field-title" role="listitem" ><a href="/en-gb/search-results/topic/clinical-decision-support">Clinical Decision Support</a></span><span class="field-title" role="listitem" ><a href="/en-gb/search-results/topic/drug-data">Drug Data</a></span><span class="field-title" role="listitem" ><a href="/en-gb/search-results/topic/drug-safety">Drug Safety</a></span><span class="field-title" role="listitem" ><a href="/en-gb/search-results/topic/personalized-medicine">Personalized Medicine</a></span></div></div> </div> </div> </div> </div> </div> <div class="container-fluid"> <div > <div class="row"> <div class="component productpromo medium-gray-bg col-12 compact"> <div class="component-content"> <div class="product-wrapper"><div class="productpromo-eyebrow field-eyebrow">Solutions</div><h4 class="productpromo-name field-name">UpToDate Lexidrug</h4><div class="productpromo-description field-description">Evidence-based drug reference solution used in the workflow and on-the-go</div><div class="productpromo-link field-link"><a data-variantfieldname="Link" data-dm-wk="productpromotion.button" href="/en-gb/solutions/uptodate/enterprise/lexidrug" data-variantitemid="{F39B5812-6837-4C6E-A63E-BD6147C7E81B}">Learn More</a></div></div><div class="details-wrapper"><div class="productpromo-fulldescription field-full-description">Clinicians choose UpToDate® Lexidrug™ for evidence-based drug information to support smart, safe medication decisions. 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