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(Credit: Joanna Ciatti and Jihum Park) Researchers have developed a device that may rescue people from overdose without bystander help. In animal studies, the researchers found that the implantable device detects an overdose, rapidly delivers naloxone to prevent death, and alerts emergency first responders."> <meta property="og:image" content="http://res.cloudinary.com/tbmg/ar_16:9,c_thumb,g_auto:subject,f_auto,q_auto/c_limit,w_400/v1730928396/sites/mdb/features-16x9/52020/20241107_medical_design_story1_primary-feature-item.jpg"> <meta property="og:image:secure_url" content="https://res.cloudinary.com/tbmg/ar_16:9,c_thumb,g_auto:subject,f_auto,q_auto/c_limit,w_400/v1730928396/sites/mdb/features-16x9/52020/20241107_medical_design_story1_primary-feature-item.jpg"> <meta property="og:url" content="https://www.medicaldesignbriefs.com/component/content/article/52020-implantable-device-prevents-death-from-opioid-overdose"> <meta property="og:title" content="Implantable Device Prevents Death from Opioid Overdose"> <meta property="og:type" content="article"> <meta property="og:locale" content="en_US"> <meta property="og:updated_time" content="2024-11-06 21:20:31"> <meta property="article:modified_time" content="2024-11-06 21:20:31"> <meta property="article:publisher" content="SAE Media Group"> <meta name="description" content=" Researchers from WashU Medicine and Northwestern University developed an implantable device that can detect an overdose and rapidly deliver naloxone. (Credit: Joanna Ciatti and Jihum Park) Researchers have developed a device that may rescue people from overdose without bystander help. In animal studies, the researchers found that the implantable device detects an overdose, rapidly delivers naloxone to prevent death, and alerts emergency first responders."> <title>Implantable Device Prevents Death from Opioid Overdose - Medical Design Briefs</title> <link href="https://www.medicaldesignbriefs.com/component/content/article/52020-implantable-device-prevents-death-from-opioid-overdose" rel="canonical"> <style> /*! inlined from /media/plg_content_ntb_tagsbot/css/template.min.css by ntb_minifier */ .ntb_tagsbot .taglist { font-style: italic; margin-top: 10px } .ntb_tagsbot .tagmenus { background: #FFE; border: 1px dashed #DDD; padding: 10px; margin-bottom: 10px } .ntb_tagsbot .clusterlist { font-style: italic; margin-bottom: 10px; } .ntb_cluster_div { display: none; } .tagmenus div:first-of-type { font-style: italic; margin-bottom: 10px; } /* end /media/plg_content_ntb_tagsbot/css/template.min.css */ </style> <link 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var(--bs-nav-link-padding-x);font-size:var(--bs-nav-link-font-size);font-weight:var(--bs-nav-link-font-weight);color:var(--bs-nav-link-color)}.nav-fill .nav-item{flex:1 1 auto;text-align:center}.nav-fill .nav-item .nav-link{width:100%}.navbar{--bs-navbar-padding-x:0;--bs-navbar-padding-y:0.5rem;--bs-navbar-color:rgba(0, 0, 0, 0.55);--bs-navbar-hover-color:rgba(0, 0, 0, 0.7);--bs-navbar-disabled-color:rgba(0, 0, 0, 0.3);--bs-navbar-active-color:rgba(0, 0, 0, 0.9);--bs-navbar-brand-padding-y:0.25rem;--bs-navbar-brand-margin-end:1rem;--bs-navbar-brand-font-size:1.25rem;--bs-navbar-brand-color:rgba(0, 0, 0, 0.9);--bs-navbar-brand-hover-color:rgba(0, 0, 0, 0.9);--bs-navbar-nav-link-padding-x:0.5rem;--bs-navbar-toggler-padding-y:0.25rem;--bs-navbar-toggler-padding-x:0.75rem;--bs-navbar-toggler-font-size:1.25rem;--bs-navbar-toggler-icon-bg:url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%280, 0, 0, 0.55%29' stroke-linecap='round' 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var(--bs-navbar-padding-x);background-image:var(--bs-gradient)}.navbar>.container,.navbar>.container-fluid{display:flex;flex-wrap:inherit;align-items:center;justify-content:space-between}.navbar-brand{padding-top:var(--bs-navbar-brand-padding-y);padding-bottom:var(--bs-navbar-brand-padding-y);margin-right:var(--bs-navbar-brand-margin-end);font-size:var(--bs-navbar-brand-font-size);color:var(--bs-navbar-brand-color);white-space:nowrap}.navbar-nav{--bs-nav-link-padding-x:0;--bs-nav-link-padding-y:0.7rem;--bs-nav-link-color:var(--bs-navbar-color);--bs-nav-link-hover-color:var(--bs-navbar-hover-color);--bs-nav-link-disabled-color:var(--bs-navbar-disabled-color);display:flex;flex-direction:column;padding-left:0;margin-bottom:0;list-style:none}.navbar-collapse{flex-basis:100%;flex-grow:1;align-items:center}.navbar-toggler{padding:var(--bs-navbar-toggler-padding-y) var(--bs-navbar-toggler-padding-x);font-size:var(--bs-navbar-toggler-font-size);line-height:1;color:var(--bs-navbar-color);background-color:transparent;border:var(--bs-border-width) solid var(--bs-navbar-toggler-border-color);border-radius:var(--bs-navbar-toggler-border-radius)}@media (min-width:576px){.navbar-expand-sm{flex-wrap:nowrap;justify-content:flex-start}.navbar-expand-sm .navbar-nav{flex-direction:row}.navbar-expand-sm .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-sm .navbar-collapse{display:flex!important;flex-basis:auto}.navbar-expand-sm .navbar-toggler{display:none}}body:before{display:none}.navbar-dark{--bs-navbar-color:#324a98;--bs-navbar-hover-color:#4d4d4f;--bs-navbar-disabled-color:rgba(255, 255, 255, 0.25);--bs-navbar-active-color:#324a98;--bs-navbar-brand-color:#324a98;--bs-navbar-brand-hover-color:#324a98;--bs-navbar-toggler-border-color:transparent;--bs-navbar-toggler-icon-bg:none}.card{--bs-card-spacer-y:1rem;--bs-card-spacer-x:1rem;--bs-card-title-spacer-y:0.5rem;--bs-card-border-width:1px;--bs-card-border-color:var(--bs-border-color-translucent);--bs-card-border-radius:0.375rem;--bs-card-inner-border-radius:calc(0.375rem - 1px);--bs-card-cap-padding-y:0.5rem;--bs-card-cap-padding-x:1rem;--bs-card-cap-bg:rgba(0, 0, 0, 0.03);--bs-card-bg:#f8f9fa;--bs-card-img-overlay-padding:1rem;--bs-card-group-margin:0.75rem;position:relative;display:flex;flex-direction:column;min-width:0;height:var(--bs-card-height);word-wrap:break-word;background-color:var(--bs-card-bg);background-clip:border-box;border:var(--bs-card-border-width) solid var(--bs-card-border-color);border-radius:var(--bs-card-border-radius);box-shadow:var(--bs-card-box-shadow)}.card-body{flex:1 1 auto;padding:var(--bs-card-spacer-y) var(--bs-card-spacer-x);color:var(--bs-card-color)}.breadcrumb{display:flex;list-style:none;--bs-breadcrumb-padding-x:0;--bs-breadcrumb-padding-y:0.5rem;--bs-breadcrumb-margin-bottom:0;--bs-breadcrumb-font-size:0.75rem;--bs-breadcrumb-bg:transparent;--bs-breadcrumb-divider-color:#6c757d;--bs-breadcrumb-item-padding-x:0.5rem;--bs-breadcrumb-item-active-color:#6c757d;flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "|")}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.alert{--bs-alert-bg:transparent;--bs-alert-padding-x:1rem;--bs-alert-padding-y:1rem;--bs-alert-margin-bottom:1rem;--bs-alert-color:inherit;--bs-alert-border-color:transparent;--bs-alert-border:1px solid var(--bs-alert-border-color);--bs-alert-border-radius:0.375rem;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-primary,.alert-secondary{background-image:var(--bs-gradient)}.alert-primary{--bs-alert-color:rgb(30, 44.4, 91.2);--bs-alert-bg:rgb(214, 218.8, 234.4);--bs-alert-border-color:rgb(193.5, 200.7, 224.1)}.alert-primary .alert-link{color:#182449}.alert-secondary{--bs-alert-color:rgb(64.8, 70.2, 75);--bs-alert-bg:rgb(225.6, 227.4, 229);--bs-alert-border-color:rgb(210.9, 213.6, 216)}.alert-secondary .alert-link{color:#34383c}.alert-native,.alert-success,.alert-validation{--bs-alert-color:rgb(15, 81, 50.4);--bs-alert-bg:rgb(209, 231, 220.8);--bs-alert-border-color:rgb(186, 219, 203.7);background-image:var(--bs-gradient)}.alert-native .alert-link,.alert-success .alert-link,.alert-validation .alert-link{color:#0c4128}.alert-info,.alert-warning{background-image:var(--bs-gradient)}.alert-info{--bs-alert-color:rgb(5.2, 80.8, 96);--bs-alert-bg:rgb(206.6, 244.4, 252);--bs-alert-border-color:rgb(182.4, 239.1, 250.5)}.alert-info .alert-link{color:#04414d}.alert-warning{--bs-alert-color:rgb(102, 77.2, 2.8);--bs-alert-bg:rgb(255, 242.6, 205.4);--bs-alert-border-color:rgb(255, 236.4, 180.6)}.alert-warning .alert-link{color:#523e02}.alert-danger,.alert-error{--bs-alert-color:#8a0000;--bs-alert-bg:#facccc;--bs-alert-border-color:rgb(247.5, 178.5, 178.5);background-image:var(--bs-gradient)}.alert-danger .alert-link,.alert-error .alert-link{color:#6e0000}.alert-light{--bs-alert-color:rgb(99.2, 99.6, 100);--bs-alert-bg:rgb(253.6, 253.8, 254);--bs-alert-border-color:rgb(252.9, 253.2, 253.5);background-image:var(--bs-gradient)}.alert-light .alert-link{color:#4f5050}.alert-cleanup,.alert-dark{--bs-alert-color:rgb(19.8, 22.2, 24.6);--bs-alert-bg:rgb(210.6, 211.4, 212.2);--bs-alert-border-color:rgb(188.4, 189.6, 190.8);background-image:var(--bs-gradient)}.alert-cleanup .alert-link,.alert-dark .alert-link{color:#101214}.alert-inverse{--bs-alert-color:#666666;--bs-alert-bg:white;--bs-alert-border-color:white}.alert-inverse .alert-link{color:#525252}.alert-inverse,.alert-navbar,.alert-navitem{background-image:var(--bs-gradient)}.alert-navbar{--bs-alert-color:rgb(87.2, 88, 88.8);--bs-alert-bg:rgb(247.6, 248, 248.4);--bs-alert-border-color:rgb(243.9, 244.5, 245.1)}.alert-navbar .alert-link{color:#464647}.alert-navitem{--bs-alert-color:#666666;--bs-alert-bg:white;--bs-alert-border-color:white}.alert-navitem .alert-link{color:#525252}.alert-lightgray{--bs-alert-color:rgb(93.2, 94.4, 95.6);--bs-alert-bg:rgb(250.6, 251.2, 251.8);--bs-alert-border-color:rgb(248.4, 249.3, 250.2)}.alert-lightgray .alert-link{color:#4b4c4c}.alert-color-indigo,.alert-lightgray{background-image:var(--bs-gradient)}.alert-advertising,.alert-color-indigo{--bs-alert-color:rgb(61.2, 9.6, 145.2);--bs-alert-bg:rgb(224.4, 207.2, 252.4);--bs-alert-border-color:rgb(209.1, 183.3, 251.1)}.alert-color-indigo .alert-link{color:#310874}.alert-color-cyan{--bs-alert-color:rgb(5.2, 80.8, 96);--bs-alert-bg:rgb(206.6, 244.4, 252);--bs-alert-border-color:rgb(182.4, 239.1, 250.5);background-image:var(--bs-gradient)}.alert-color-cyan .alert-link{color:#04414d}.alert-color-blue,.alert-criticalcss{--bs-alert-color:rgb(7.8, 66, 151.8);--bs-alert-bg:rgb(206.6, 226, 254.6);--bs-alert-border-color:rgb(182.4, 211.5, 254.4);background-image:var(--bs-gradient)}.alert-color-blue .alert-link,.alert-criticalcss .alert-link{color:#063579}.alert-color-orange{background-image:var(--bs-gradient)}.alert-cache,.alert-color-orange{--bs-alert-color:rgb(151.8, 75.6, 12);--bs-alert-bg:rgb(254.6, 229.2, 208);--bs-alert-border-color:rgb(254.4, 216.3, 184.5)}.alert-color-orange .alert-link{color:#793c0a}.alert-color-red{--bs-alert-color:rgb(132, 31.8, 41.4);--bs-alert-bg:rgb(248, 214.6, 217.8);--bs-alert-border-color:rgb(244.5, 194.4, 199.2);background-image:var(--bs-gradient)}.alert-color-red .alert-link{color:#6a1921}.alert-cdnjs,.alert-color-yellow{--bs-alert-color:rgb(102, 77.2, 2.8);--bs-alert-bg:rgb(255, 242.6, 205.4);--bs-alert-border-color:rgb(255, 236.4, 180.6)}.alert-cdnjs .alert-link,.alert-color-yellow .alert-link{color:#523e02}.alert-cdnjs,.alert-color-teal,.alert-color-yellow{background-image:var(--bs-gradient)}.alert-color-teal,.alert-topic{--bs-alert-color:rgb(19.2, 120.6, 90.6);--bs-alert-bg:rgb(210.4, 244.2, 234.2);--bs-alert-border-color:rgb(188.1, 238.8, 223.8)}.alert-color-teal .alert-link{color:#0f6048}.alert-color-green{--bs-alert-color:rgb(15, 81, 50.4);--bs-alert-bg:rgb(209, 231, 220.8);--bs-alert-border-color:rgb(186, 219, 203.7);background-image:var(--bs-gradient)}.alert-color-green .alert-link{color:#0c4128}.alert-cloudinary,.alert-color-pink{--bs-alert-color:rgb(128.4, 30.6, 79.2);--bs-alert-bg:rgb(246.8, 214.2, 230.4);--bs-alert-border-color:rgb(242.7, 193.8, 218.1);background-image:var(--bs-gradient)}.alert-cloudinary .alert-link,.alert-color-pink .alert-link{color:#67183f}.alert-color-black{--bs-alert-color:black;--bs-alert-bg:#cccccc;--bs-alert-border-color:rgb(178.5, 178.5, 178.5);background-image:var(--bs-gradient)}.alert-color-black .alert-link{color:#000}.alert-color-white{--bs-alert-color:#666666;--bs-alert-bg:white;--bs-alert-border-color:white;background-image:var(--bs-gradient)}.alert-color-white .alert-link{color:#525252}.alert-color-gray{--bs-alert-color:rgb(64.8, 70.2, 75);--bs-alert-bg:rgb(225.6, 227.4, 229);--bs-alert-border-color:rgb(210.9, 213.6, 216);background-image:var(--bs-gradient)}.alert-color-gray .alert-link{color:#34383c}.alert-color-gray-dark{--bs-alert-color:rgb(31.2, 34.8, 38.4);--bs-alert-bg:rgb(214.4, 215.6, 216.8);--bs-alert-border-color:rgb(194.1, 195.9, 197.7);background-image:var(--bs-gradient)}.alert-color-gray-dark .alert-link{color:#191c1f}.alert-cache{--bs-alert-color:rgb(61.2, 9.6, 145.2);--bs-alert-bg:rgb(224.4, 207.2, 252.4);--bs-alert-border-color:rgb(209.1, 183.3, 251.1);background-image:var(--bs-gradient)}.alert-cache .alert-link{color:#310874}.alert-notice{--bs-alert-color:rgb(5.2, 80.8, 96);--bs-alert-bg:rgb(206.6, 244.4, 252);--bs-alert-border-color:rgb(182.4, 239.1, 250.5)}.alert-notice .alert-link{color:#04414d}.alert-advertising,.alert-notice,.alert-topic{background-image:var(--bs-gradient)}.alert-topic{--bs-alert-color:rgb(113.4, 34.2, 10.2);--bs-alert-bg:rgb(241.8, 215.4, 207.4);--bs-alert-border-color:rgb(235.2, 195.6, 183.6)}.alert-topic .alert-link{color:#5b1b08}.alert-advertising{--bs-alert-color:rgb(102, 77.2, 2.8);--bs-alert-bg:rgb(255, 242.6, 205.4);--bs-alert-border-color:rgb(255, 236.4, 180.6)}.alert-advertising .alert-link{color:#523e02}.list-group{--bs-list-group-color:#212529;--bs-list-group-bg:#fff;--bs-list-group-border-color:rgba(0, 0, 0, 0.125);--bs-list-group-border-width:1px;--bs-list-group-border-radius:0.375rem;--bs-list-group-item-padding-x:1rem;--bs-list-group-item-padding-y:0.5rem;--bs-list-group-action-color:#495057;--bs-list-group-action-hover-color:#495057;--bs-list-group-action-hover-bg:#f8f9fa;--bs-list-group-action-active-color:#212529;--bs-list-group-action-active-bg:#e9ecef;--bs-list-group-disabled-color:#6c757d;--bs-list-group-disabled-bg:#fff;--bs-list-group-active-color:#fff;--bs-list-group-active-bg:#bd3911;--bs-list-group-active-border-color:#bd3911;display:flex;flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item+.list-group-item{border-top-width:0}.btn-close{box-sizing:content-box;width:1em;height:1em;padding:.25em;color:#000;background:url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23000'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e") center/1em auto no-repeat;border:0;border-radius:.375rem;opacity:.5}.modal{--bs-modal-zindex:1055;--bs-modal-width:500px;--bs-modal-padding:1rem;--bs-modal-margin:0.5rem;--bs-modal-bg:#fff;--bs-modal-border-color:var(--bs-border-color-translucent);--bs-modal-border-width:1px;--bs-modal-border-radius:0.5rem;--bs-modal-box-shadow:0 0.125rem 0.25rem rgba(0, 0, 0, 0.075);--bs-modal-inner-border-radius:calc(0.5rem - 1px);--bs-modal-header-padding-x:1rem;--bs-modal-header-padding-y:1rem;--bs-modal-header-padding:1rem 1rem;--bs-modal-header-border-color:var(--bs-border-color);--bs-modal-header-border-width:1px;--bs-modal-title-line-height:1.5;--bs-modal-footer-gap:0.5rem;--bs-modal-footer-border-color:var(--bs-border-color);--bs-modal-footer-border-width:1px;position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin)}.modal.fade .modal-dialog{transform:translate(0,-50px)}.modal-content{position:relative;display:flex;flex-direction:column;width:100%;color:var(--bs-modal-color);background-color:var(--bs-modal-bg);background-clip:padding-box;border:var(--bs-modal-border-width) solid var(--bs-modal-border-color);border-radius:var(--bs-modal-border-radius);box-shadow:var(--bs-modal-box-shadow);outline:0}.modal-header{display:flex;flex-shrink:0;align-items:center;justify-content:space-between;padding:var(--bs-modal-header-padding);border-bottom:var(--bs-modal-header-border-width) solid var(--bs-modal-header-border-color);border-top-left-radius:var(--bs-modal-inner-border-radius);border-top-right-radius:var(--bs-modal-inner-border-radius)}.modal-title{margin-bottom:0;line-height:var(--bs-modal-title-line-height)}.modal-body{position:relative;flex:1 1 auto;padding:var(--bs-modal-padding)}@media (min-width:576px){.modal{--bs-modal-margin:1.75rem;--bs-modal-box-shadow:0 0.5rem 1rem rgba(0, 0, 0, 0.15)}.modal-dialog{max-width:var(--bs-modal-width);margin-right:auto;margin-left:auto}.modal-sm{--bs-modal-width:300px}}.offcanvas{--bs-offcanvas-zindex:1045;--bs-offcanvas-width:400px;--bs-offcanvas-height:30vh;--bs-offcanvas-padding-x:1rem;--bs-offcanvas-padding-y:1rem;--bs-offcanvas-bg:#fff;--bs-offcanvas-border-width:1px;--bs-offcanvas-border-color:var(--bs-border-color-translucent);--bs-offcanvas-box-shadow:0 0.125rem 0.25rem rgba(0, 0, 0, 0.075);position:fixed;bottom:0;z-index:var(--bs-offcanvas-zindex);display:flex;flex-direction:column;max-width:100%;color:var(--bs-offcanvas-color);visibility:hidden;background-color:var(--bs-offcanvas-bg);background-clip:padding-box;outline:0;box-shadow:var(--bs-offcanvas-box-shadow)}.offcanvas.offcanvas-start{top:0;left:0;width:var(--bs-offcanvas-width);border-right:var(--bs-offcanvas-border-width) solid 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src='data:image/svg+xml;base64,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' data-src='https://res.cloudinary.com/tbmg/c_scale,w_auto,f_auto,q_auto/v1730928368/sites/mdb/articles/2024/insider/20241107_Medical_Design_Story1.jpg' class=' w-100 cld-responsive' alt='' alt="WashU Medicine Image" data-path="local-images:/stories/MDB/2024/insider/20241107_Medical_Design_Story1.jpg" /> <figcaption>Researchers from WashU Medicine and Northwestern University developed an implantable device that can detect an overdose and rapidly deliver naloxone. (Credit: Joanna Ciatti and Jihum Park)</figcaption></figure> <p>Researchers have developed a device that may rescue people from overdose without bystander help. In animal studies, the researchers found that the implantable device detects an overdose, rapidly delivers naloxone to prevent death, and alerts emergency first responders.</p> <p>The device — the Naloximeter — uses a drop in oxygen levels as a signal for a potential overdose. Overdosing on opioids leads to slow and shallow breathing. Minutes after the drugs begin to impact respiratory function, breathing stops. Implanted under the skin, the Naloximeter senses oxygen in the surrounding tissues, sending a warning notification to a mobile application if the levels drop below a threshold. If the user doesn’t abort the rescue process within 30 seconds, the device releases stored naloxone.</p><div class="ad-position g-0 row mb-3 "> <div class="col-12 align-content-center mx-auto"> <script tb-donotmove>window.ntb_google_ad_manager_items=window.ntb_google_ad_manager_items||[];ntb_google_ad_manager_items.push({display_sizes:['xs','sm'],slot_ad_unit:'medicaldesignbriefs.com_450x450_300x300',slot_code:'21835072403',slot:'/21835072403/medicaldesignbriefs.com_450x450_300x300',slot_ad_sizes:['fluid',[450,450],[300,300]],div_id:'GAM_pos_22_modid_421',target_pos:'22',size_mapping:[],slot_ad_empty:'default'});</script> <div id='GAM_pos_22_modid_421' class=""></div></div></div><p>The researchers implanted the device in the neck, chest or back of small and large animals. The device detected signs of overdose within a minute of dropping oxygen levels, and all animals fully recovered within five minutes of receiving naloxone from the devices.</p> <p> <a href="https://medicine.washu.edu/news/implantable-device-may-prevent-death-from-opioid-overdose/" target="_blank" rel="noopener" rel="noopener noreferrer">Source <i class="fad fa-external-link fa-sm"></i></a></p> <hr> <div class="ntb_tagsbot"> <div class="taglist"> <strong class="sans-serif text-small">Topics:</strong><br> <a class="badge bg-primary link-white fw-light sans-serif text-small fst-normal" href="/component/ntb_tags/topic/medical/diagnostics/mdb/*?start=0"> <i class="fa-duotone fa-book-medical"></i> Diagnostics</a> <a class="badge bg-primary link-white fw-light sans-serif text-small fst-normal" href="/component/ntb_tags/topic/medical/drug_delivery/mdb/*?start=0"> <i class="fa-duotone fa-book-medical"></i> Drug Delivery</a> <a class="badge bg-primary link-white fw-light sans-serif text-small 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