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My teaching activity is based mostly on genetics and molecular biology. I am part of the Chrome Unit, a dynamic and varied group of research with different interests in the field of chronic and emergent risks. We are currently studying the impact of environmental contaminants and bacterial infections on neurological diseases.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="27885150" href="https://www.academia.edu/Documents/in/Gut_Microbiota"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://unimes.academia.edu/PatriziaGiannoni","location":"/PatriziaGiannoni","scheme":"https","host":"unimes.academia.edu","port":null,"pathname":"/PatriziaGiannoni","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" 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(Conférencière invitée)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/93145829/Caract%C3%A9risation_immunohistologique_de_la_pathologie_amylo%C3%AFde_et_des_sympt%C3%B4mes_associ%C3%A9s_dans_un_mod%C3%A8le_murin_dela_maladie_dAlzheimer_Conf%C3%A9renci%C3%A8re_invit%C3%A9e_">Caractérisation immunohistologique de la pathologie amyloïde et des symptômes associés dans un modèle murin dela maladie d'Alzheimer. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93145828"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/93145828/Time_dependent_vascular_pericyte_changes_in_a_genetic_model_of_Alzheimer_s_disease"><img alt="Research paper thumbnail of Time dependent vascular pericyte changes in a genetic model of Alzheimer’s disease" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/93145828/Time_dependent_vascular_pericyte_changes_in_a_genetic_model_of_Alzheimer_s_disease">Time dependent vascular pericyte changes in a genetic model of Alzheimer’s disease</a></div><div class="wp-workCard_item"><span>Le Centre pour la Communication Scientifique Directe - HAL - Inria</span><span>, Jul 6, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">International audienc</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="93145828"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="93145828"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 93145828; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93145827"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/93145827/Environmental_and_Health_Impact_of_Micropollutants_in_the_Thau_Lagoon"><img alt="Research paper thumbnail of Environmental and Health Impact of Micropollutants in the Thau Lagoon" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/93145827/Environmental_and_Health_Impact_of_Micropollutants_in_the_Thau_Lagoon">Environmental and Health Impact of Micropollutants in the Thau Lagoon</a></div><div class="wp-workCard_item"><span>SCICON2 - SETAC North America 41st Annual Meeting</span><span>, Nov 15, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">International audienceThau lagoon (extended on 7500 hectares) is located in the south of France a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">International audienceThau lagoon (extended on 7500 hectares) is located in the south of France and is the main shellfish-farming center in the Mediterranean Sea. Around this lagoon, numerous activities such as wastewater treatment plants, harbor and vine cultivation represent a potential source of pollution. Although subject to microbiological and chemical monitoring (heavy metals), there is currently no global study realized on the contamination of air and water. This work proposes an integrated approach based on a non-target analysis by SBSE/HSSE coupled with GC-MS and a target analysis in order to identify chemical pollutants (heavy metals, 34 pharmaceuticals, 12 pesticides, 2 industrial products and 6 toxins). This monitoring was carried out during one year on 6 sampling points and on two matrices: air (non-target analysis) and water (non-target and target analysis). Concerning the targeted analysis, very low concentrations ranging from the pg/L to the ng/L were found in water. Among pollutants, most frequently found are: atrazine, its metabolites, azithromycin, clarithromycin, atenolol and sotalol at low concentrations ranging from 2.44 pg/L to 0.6 ng/L. In contrast, in non-targeted analysis, 116 different molecules were found including 77 and 79 in the air and water respectively. Only 28 molecules were common to both matrices. To access the exposure risk of workers and residents of the lagoon, we have in second approach decided to select some molecules from the non-target analysis and to quantify them. The selection was based on the toxicity of the molecules (Toxtree software) and their frequency of detection. Only the molecules found in more than 20% of sampling were conserved for the analysis. Examples of potentially dangerous susbtances included in this list are: - triethyl phosphate (organophosphorus flame-retardant and intermediate in the manufacture for pesticides), - diisobutyl phthalate (endocrine disruptor). This substance is considered of very high concern (SVHC) and its use is strictly regulated (Annex XVII of REACH1) - 2-furanmethanol. This molecule is included in the list of hazardous substances harmonised for classification and labelling in the EU (Annex VI to CLP regulation)2 and is suspected to be carcinogenic. The next step of the study will be to made analysis on the shellfishes grown in the lagoon. All of these elements will allow to trace pollutants in the Thau lagoon and to determine the potential sources of exposition and potential bioaccumulation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="93145827"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="93145827"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 93145827; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=93145827]").text(description); $(".js-view-count[data-work-id=93145827]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 93145827; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='93145827']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 93145827, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=93145827]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":93145827,"title":"Environmental and Health Impact of Micropollutants in the Thau Lagoon","translated_title":"","metadata":{"abstract":"International audienceThau lagoon (extended on 7500 hectares) is located in the south of France and is the main shellfish-farming center in the Mediterranean Sea. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80261370"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80261370/Serotonin_A_New_Hope_in_Alzheimers_Disease"><img alt="Research paper thumbnail of Serotonin: A New Hope in Alzheimer's Disease?" class="work-thumbnail" src="https://attachments.academia-assets.com/86701856/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80261370/Serotonin_A_New_Hope_in_Alzheimers_Disease">Serotonin: A New Hope in Alzheimer's Disease?</a></div><div class="wp-workCard_item"><span>ACS chemical neuroscience</span><span>, Jan 15, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alzheimer&#39;s disease (AD) is the most common form of dementia affecting 35 million individuals...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alzheimer&#39;s disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="803e5a29bd9a3767e2978454d33dea7d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86701856,"asset_id":80261370,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86701856/download_file?st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80261370"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80261370"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80261370; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80261370]").text(description); $(".js-view-count[data-work-id=80261370]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80261370; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80261370']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80261370, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "803e5a29bd9a3767e2978454d33dea7d" } } $('.js-work-strip[data-work-id=80261370]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80261370,"title":"Serotonin: A New Hope in Alzheimer's Disease?","translated_title":"","metadata":{"abstract":"Alzheimer\u0026#39;s disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.","publication_date":{"day":15,"month":1,"year":2015,"errors":{}},"publication_name":"ACS chemical neuroscience"},"translated_abstract":"Alzheimer\u0026#39;s disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80261366"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80261366/Novel_Multitarget_Directed_Ligands_MTDLs_with_Acetylcholinesterase_AChE_Inhibitory_and_Serotonergic_Subtype_4_Receptor_5_HT4R_Agonist_Activities_As_Potential_Agents_against_Alzheimer_s_Disease_The_Design_of_Donecopride"><img alt="Research paper thumbnail of Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride" class="work-thumbnail" src="https://attachments.academia-assets.com/86701867/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80261366/Novel_Multitarget_Directed_Ligands_MTDLs_with_Acetylcholinesterase_AChE_Inhibitory_and_Serotonergic_Subtype_4_Receptor_5_HT4R_Agonist_Activities_As_Potential_Agents_against_Alzheimer_s_Disease_The_Design_of_Donecopride">Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride</a></div><div class="wp-workCard_item"><span>Journal of Medicinal Chemistry</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="35bad0b15f94d4ef182c6a72142f5b59" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86701867,"asset_id":80261366,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86701867/download_file?st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80261366"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80261366"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80261366; 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class="js-work-strip profile--work_container" data-work-id="80259704"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80259704/Development_of_a_DGGE_method_to_explore_Legionella_communities"><img alt="Research paper thumbnail of Development of a DGGE method to explore Legionella communities" class="work-thumbnail" src="https://attachments.academia-assets.com/86700627/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80259704/Development_of_a_DGGE_method_to_explore_Legionella_communities">Development of a DGGE method to explore Legionella communities</a></div><div class="wp-workCard_item"><span>Heliyon</span><span>, 2020</span></div><div class="wp-workCard_item 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The aim of this work was to develop a method to assess the composition of the Legionella species community in an environmental sample in order to have a better understanding of the contamination of the ecosystem by pathogenic strains. The method is based on the comparison of PCR-DGGE profile of DNA sample with a database consisting in DGGE profiles of Legionella species. Such a database includes all pathogenic Legionella strains. In order to homogenize and normalize the different DGGE fingerprint, a reference marker has been built and added during DGGE gel analysis. 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Imaging of the Cerebrovasculature: Relevance to CNS Diseases</a></div><div class="wp-workCard_item"><span>Journal of Visualized Experiments</span><span>, Dec 6, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="07b19f88b94a0c52378ca5f6831b3ce4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116672920,"asset_id":121899759,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116672920/download_file?st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121899759"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121899759"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121899759; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93145830"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/93145830/Impact_du_microbiote_intestinal_dans_un_mod%C3%A8le_murin_de_maladie_d_Alzheimer"><img alt="Research paper thumbnail of Impact du microbiote intestinal dans un modèle murin de maladie d’Alzheimer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/93145830/Impact_du_microbiote_intestinal_dans_un_mod%C3%A8le_murin_de_maladie_d_Alzheimer">Impact du microbiote intestinal dans un modèle murin de maladie d’Alzheimer</a></div><div class="wp-workCard_item"><span>Le Centre pour la Communication Scientifique Directe - HAL - Université de Nantes</span><span>, Jun 8, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">International audienc</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="93145830"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="93145830"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 93145830; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93145829"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/93145829/Caract%C3%A9risation_immunohistologique_de_la_pathologie_amylo%C3%AFde_et_des_sympt%C3%B4mes_associ%C3%A9s_dans_un_mod%C3%A8le_murin_dela_maladie_dAlzheimer_Conf%C3%A9renci%C3%A8re_invit%C3%A9e_"><img alt="Research paper thumbnail of Caractérisation immunohistologique de la pathologie amyloïde et des symptômes associés dans un modèle murin dela maladie d'Alzheimer. (Conférencière invitée)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/93145829/Caract%C3%A9risation_immunohistologique_de_la_pathologie_amylo%C3%AFde_et_des_sympt%C3%B4mes_associ%C3%A9s_dans_un_mod%C3%A8le_murin_dela_maladie_dAlzheimer_Conf%C3%A9renci%C3%A8re_invit%C3%A9e_">Caractérisation immunohistologique de la pathologie amyloïde et des symptômes associés dans un modèle murin dela maladie d'Alzheimer. (Conférencière invitée)</a></div><div class="wp-workCard_item"><span>Le Centre pour la Communication Scientifique Directe - HAL - Inria</span><span>, Jun 11, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">International audienc</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="93145829"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="93145829"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 93145829; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=93145829]").text(description); $(".js-view-count[data-work-id=93145829]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 93145829; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='93145829']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 93145829, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=93145829]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":93145829,"title":"Caractérisation immunohistologique de la pathologie amyloïde et des symptômes associés dans un modèle murin dela maladie d'Alzheimer. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93145828"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/93145828/Time_dependent_vascular_pericyte_changes_in_a_genetic_model_of_Alzheimer_s_disease"><img alt="Research paper thumbnail of Time dependent vascular pericyte changes in a genetic model of Alzheimer’s disease" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/93145828/Time_dependent_vascular_pericyte_changes_in_a_genetic_model_of_Alzheimer_s_disease">Time dependent vascular pericyte changes in a genetic model of Alzheimer’s disease</a></div><div class="wp-workCard_item"><span>Le Centre pour la Communication Scientifique Directe - HAL - Inria</span><span>, Jul 6, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">International audienc</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="93145828"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="93145828"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 93145828; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=93145828]").text(description); $(".js-view-count[data-work-id=93145828]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 93145828; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='93145828']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 93145828, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=93145828]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":93145828,"title":"Time dependent vascular pericyte changes in a genetic model of Alzheimer’s disease","translated_title":"","metadata":{"abstract":"International audienc","publication_date":{"day":6,"month":7,"year":2015,"errors":{}},"publication_name":"Le Centre pour la Communication Scientifique Directe - HAL - Inria"},"translated_abstract":"International audienc","internal_url":"https://www.academia.edu/93145828/Time_dependent_vascular_pericyte_changes_in_a_genetic_model_of_Alzheimer_s_disease","translated_internal_url":"","created_at":"2022-12-18T02:04:55.610-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":27885150,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Time_dependent_vascular_pericyte_changes_in_a_genetic_model_of_Alzheimer_s_disease","translated_slug":"","page_count":null,"language":"cy","content_type":"Work","owner":{"id":27885150,"first_name":"Patrizia","middle_initials":null,"last_name":"Giannoni","page_name":"PatriziaGiannoni","domain_name":"unimes","created_at":"2015-03-16T01:10:02.634-07:00","display_name":"Patrizia Giannoni","url":"https://unimes.academia.edu/PatriziaGiannoni"},"attachments":[],"research_interests":[{"id":99773,"name":"Disease","url":"https://www.academia.edu/Documents/in/Disease"}],"urls":[{"id":27157151,"url":"https://hal.archives-ouvertes.fr/hal-02917765"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="93145827"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/93145827/Environmental_and_Health_Impact_of_Micropollutants_in_the_Thau_Lagoon"><img alt="Research paper thumbnail of Environmental and Health Impact of Micropollutants in the Thau Lagoon" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/93145827/Environmental_and_Health_Impact_of_Micropollutants_in_the_Thau_Lagoon">Environmental and Health Impact of Micropollutants in the Thau Lagoon</a></div><div class="wp-workCard_item"><span>SCICON2 - SETAC North America 41st Annual Meeting</span><span>, Nov 15, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">International audienceThau lagoon (extended on 7500 hectares) is located in the south of France a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">International audienceThau lagoon (extended on 7500 hectares) is located in the south of France and is the main shellfish-farming center in the Mediterranean Sea. Around this lagoon, numerous activities such as wastewater treatment plants, harbor and vine cultivation represent a potential source of pollution. Although subject to microbiological and chemical monitoring (heavy metals), there is currently no global study realized on the contamination of air and water. This work proposes an integrated approach based on a non-target analysis by SBSE/HSSE coupled with GC-MS and a target analysis in order to identify chemical pollutants (heavy metals, 34 pharmaceuticals, 12 pesticides, 2 industrial products and 6 toxins). This monitoring was carried out during one year on 6 sampling points and on two matrices: air (non-target analysis) and water (non-target and target analysis). Concerning the targeted analysis, very low concentrations ranging from the pg/L to the ng/L were found in water. Among pollutants, most frequently found are: atrazine, its metabolites, azithromycin, clarithromycin, atenolol and sotalol at low concentrations ranging from 2.44 pg/L to 0.6 ng/L. In contrast, in non-targeted analysis, 116 different molecules were found including 77 and 79 in the air and water respectively. Only 28 molecules were common to both matrices. To access the exposure risk of workers and residents of the lagoon, we have in second approach decided to select some molecules from the non-target analysis and to quantify them. The selection was based on the toxicity of the molecules (Toxtree software) and their frequency of detection. Only the molecules found in more than 20% of sampling were conserved for the analysis. Examples of potentially dangerous susbtances included in this list are: - triethyl phosphate (organophosphorus flame-retardant and intermediate in the manufacture for pesticides), - diisobutyl phthalate (endocrine disruptor). This substance is considered of very high concern (SVHC) and its use is strictly regulated (Annex XVII of REACH1) - 2-furanmethanol. This molecule is included in the list of hazardous substances harmonised for classification and labelling in the EU (Annex VI to CLP regulation)2 and is suspected to be carcinogenic. The next step of the study will be to made analysis on the shellfishes grown in the lagoon. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80261370"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80261370/Serotonin_A_New_Hope_in_Alzheimers_Disease"><img alt="Research paper thumbnail of Serotonin: A New Hope in Alzheimer's Disease?" class="work-thumbnail" src="https://attachments.academia-assets.com/86701856/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80261370/Serotonin_A_New_Hope_in_Alzheimers_Disease">Serotonin: A New Hope in Alzheimer's Disease?</a></div><div class="wp-workCard_item"><span>ACS chemical neuroscience</span><span>, Jan 15, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alzheimer&#39;s disease (AD) is the most common form of dementia affecting 35 million individuals...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alzheimer&#39;s disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="803e5a29bd9a3767e2978454d33dea7d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86701856,"asset_id":80261370,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86701856/download_file?st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80261370"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80261370"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80261370; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80261370]").text(description); $(".js-view-count[data-work-id=80261370]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80261370; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80261370']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80261370, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "803e5a29bd9a3767e2978454d33dea7d" } } $('.js-work-strip[data-work-id=80261370]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80261370,"title":"Serotonin: A New Hope in Alzheimer's Disease?","translated_title":"","metadata":{"abstract":"Alzheimer\u0026#39;s disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.","publication_date":{"day":15,"month":1,"year":2015,"errors":{}},"publication_name":"ACS chemical neuroscience"},"translated_abstract":"Alzheimer\u0026#39;s disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80261366"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80261366/Novel_Multitarget_Directed_Ligands_MTDLs_with_Acetylcholinesterase_AChE_Inhibitory_and_Serotonergic_Subtype_4_Receptor_5_HT4R_Agonist_Activities_As_Potential_Agents_against_Alzheimer_s_Disease_The_Design_of_Donecopride"><img alt="Research paper thumbnail of Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride" class="work-thumbnail" src="https://attachments.academia-assets.com/86701867/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80261366/Novel_Multitarget_Directed_Ligands_MTDLs_with_Acetylcholinesterase_AChE_Inhibitory_and_Serotonergic_Subtype_4_Receptor_5_HT4R_Agonist_Activities_As_Potential_Agents_against_Alzheimer_s_Disease_The_Design_of_Donecopride">Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride</a></div><div class="wp-workCard_item"><span>Journal of Medicinal Chemistry</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="35bad0b15f94d4ef182c6a72142f5b59" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86701867,"asset_id":80261366,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86701867/download_file?st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MDkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80261366"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80261366"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80261366; 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class="js-work-strip profile--work_container" data-work-id="80259704"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80259704/Development_of_a_DGGE_method_to_explore_Legionella_communities"><img alt="Research paper thumbnail of Development of a DGGE method to explore Legionella communities" class="work-thumbnail" src="https://attachments.academia-assets.com/86700627/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80259704/Development_of_a_DGGE_method_to_explore_Legionella_communities">Development of a DGGE method to explore Legionella communities</a></div><div class="wp-workCard_item"><span>Heliyon</span><span>, 2020</span></div><div class="wp-workCard_item 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The aim of this work was to develop a method to assess the composition of the Legionella species community in an environmental sample in order to have a better understanding of the contamination of the ecosystem by pathogenic strains. The method is based on the comparison of PCR-DGGE profile of DNA sample with a database consisting in DGGE profiles of Legionella species. Such a database includes all pathogenic Legionella strains. In order to homogenize and normalize the different DGGE fingerprint, a reference marker has been built and added during DGGE gel analysis. 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