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<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Search results for: Sania K. Rao</title> <meta name="description" content="Search results for: Sania K. Rao"> <meta name="keywords" content="Sania K. Rao"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Sania K. 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Rao"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 9</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Sania K. Rao</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Using Eye-Tracking Technology to Understand Consumers’ Comprehension of Multimedia Health Information</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Samiullah%20Paracha">Samiullah Paracha</a>, <a href="https://publications.waset.org/abstracts/search?q=Sania%20Jehanzeb"> Sania Jehanzeb</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20H.%20Gharanai"> M. H. Gharanai</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20R.%20Ahmadi"> A. R. Ahmadi</a>, <a href="https://publications.waset.org/abstracts/search?q=H.Sokout"> H.Sokout</a>, <a href="https://publications.waset.org/abstracts/search?q=Toshiro%20Takahara"> Toshiro Takahara</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of this study is to examine how health consumers utilize pictures when developing an understanding of multimedia health documents, and whether attentional processes, measured by eye-tracking, relate to differences in health-related cognitive resources and passage comprehension. To investigate these issues, we will present health-related text-picture passages to elders and collect eye movement data to measure readers’ looking behaviors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multimedia" title="multimedia">multimedia</a>, <a href="https://publications.waset.org/abstracts/search?q=eye-tracking" title=" eye-tracking"> eye-tracking</a>, <a href="https://publications.waset.org/abstracts/search?q=consumer%20health%20informatics" title=" consumer health informatics"> consumer health informatics</a>, <a href="https://publications.waset.org/abstracts/search?q=human-computer%20interaction" title=" human-computer interaction "> human-computer interaction </a> </p> <a href="https://publications.waset.org/abstracts/13830/using-eye-tracking-technology-to-understand-consumers-comprehension-of-multimedia-health-information" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13830.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">337</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> A Study of the Relationship between Time Management Behaviour and Job Satisfaction of Higher Education Institutes in India</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sania%20K.%20Rao">Sania K. Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=Feza%20T.%20Azmi"> Feza T. Azmi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of the present study is to explore the relationship between time management behaviour and job satisfaction of academicians of higher education institutes in India. The analyses of this study were carried out with AMOS (version 20.0); and Confirmatory Factor Analysis (CFA) and Structural Equation Modelling (SEM) were conducted. The factor analysis and findings show that perceived control of time serves as the partial mediating factor to have a significant and positive influence on job satisfaction. Further, at the end, a number of suggestions to improve one’s time management behaviour were provided. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=time%20management%20behaviour" title="time management behaviour">time management behaviour</a>, <a href="https://publications.waset.org/abstracts/search?q=job%20satisfaction" title=" job satisfaction"> job satisfaction</a>, <a href="https://publications.waset.org/abstracts/search?q=higher%20education" title=" higher education"> higher education</a>, <a href="https://publications.waset.org/abstracts/search?q=India" title=" India"> India</a>, <a href="https://publications.waset.org/abstracts/search?q=mediation%20analysis" title=" mediation analysis"> mediation analysis</a> </p> <a href="https://publications.waset.org/abstracts/80718/a-study-of-the-relationship-between-time-management-behaviour-and-job-satisfaction-of-higher-education-institutes-in-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80718.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">389</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Informational Efficiency and Integration: Evidence from Gulf Cooperation Council (GCC) Shariah Equity Market</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sania%20Ashraf">Sania Ashraf</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The paper focuses on the prevalence of informational efficiency and integration of GCC Shariah Equity market for the period of 01st January 2010 to 31st June 2015 with daily equity returns of Kuwait, Oman, Qatar, Bahrain, Saudi Arabia and United Arab Emirates. The study employs traditional as well as the modern approach of tracing out the efficiency and integration in the return series. From the results of efficiency it was observed that the market lacked efficiency in terms of its past information. The results of integration test clearly indicates that there was a long memory in the returns of GCC Shariah during the study period. Hence it was concluded and proved that the returns of all GCC Equity Shariah were not informationally efficient but fractionally integrated during the study period. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=efficiency" title="efficiency">efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=Fama" title=" Fama"> Fama</a>, <a href="https://publications.waset.org/abstracts/search?q=GCC%20shariah" title=" GCC shariah"> GCC shariah</a>, <a href="https://publications.waset.org/abstracts/search?q=hurst%20exponent" title=" hurst exponent"> hurst exponent</a>, <a href="https://publications.waset.org/abstracts/search?q=integration" title=" integration"> integration</a>, <a href="https://publications.waset.org/abstracts/search?q=serial%20correlation" title=" serial correlation"> serial correlation</a> </p> <a href="https://publications.waset.org/abstracts/50792/informational-efficiency-and-integration-evidence-from-gulf-cooperation-council-gcc-shariah-equity-market" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50792.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">362</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Evaluation of the Electric Vehicle Impact in Distribution System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sania%20Maghsodloo">Sania Maghsodloo</a>, <a href="https://publications.waset.org/abstracts/search?q=Sirus%20Mohammadi"> Sirus Mohammadi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Electric Vehicle (EV) technology is expected to take a major share in the light-vehicle market in the coming decades. Transportation electrification has become an important issue in recent decades and the large scale deployment of EVs has yet to be achieved. The smart coordination of EV demand addresses an improvement in the flexibility of power systems and reduces the costs of power system investment. The uncertainty in EV drivers’ behaviour is one of the main problems to solve to obtain an optimal integration of EVs into power systems Charging of EVs will put an extra burden on the distribution grid and in some cases adjustments will need to be made. The stochastic process of the driving pattern is done to make the outcome of the project more realistic. Based on the stochastic data, the optimization of charging plans is made. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electric%20vehicles%20%28PEVs%29" title="electric vehicles (PEVs)">electric vehicles (PEVs)</a>, <a href="https://publications.waset.org/abstracts/search?q=smart%20grid" title=" smart grid"> smart grid</a>, <a href="https://publications.waset.org/abstracts/search?q=Monticello" title=" Monticello"> Monticello</a>, <a href="https://publications.waset.org/abstracts/search?q=distribution%20system" title=" distribution system"> distribution system</a> </p> <a href="https://publications.waset.org/abstracts/21027/evaluation-of-the-electric-vehicle-impact-in-distribution-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21027.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">552</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Radio-Frequency Identification (RFID) Based Smart Helmet for Coal Miners</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Waheeda%20Jabbar">Waheeda Jabbar</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Gul"> Ali Gul</a>, <a href="https://publications.waset.org/abstracts/search?q=Rida%20Noor"> Rida Noor</a>, <a href="https://publications.waset.org/abstracts/search?q=Sania%20Kurd"> Sania Kurd</a>, <a href="https://publications.waset.org/abstracts/search?q=Saba%20Gulzar"> Saba Gulzar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hundreds of miners die from mining accidents each year due to poisonous gases found underground mining areas. This paper proposed an idea to protect the precious lives of mining workers. A supervising system is designed which is based on ZigBee wireless technique along with the smart protective helmets to detect real-time surveillance and it gives early warnings on presence of different poisonous gases in order to save mineworkers from any danger caused by these poisonous gases. A wireless sensor network is established using ZigBee wireless technique by integrating sensors on the helmet, apart from this helmet have embedded heartbeat sensor to detect the pulse rate and be aware of the physical or mental strength of a mineworker to increase the potential safety. Radio frequency identification (RFID) technology is used to find the location of workers. A ZigBee based base station is set-upped to control the communication. The idea is implemented and results are verified through experiment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arduino" title="Arduino">Arduino</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20sensor%20%28MQ7%29" title=" gas sensor (MQ7)"> gas sensor (MQ7)</a>, <a href="https://publications.waset.org/abstracts/search?q=RFID" title=" RFID"> RFID</a>, <a href="https://publications.waset.org/abstracts/search?q=wireless%20ZigBee" title=" wireless ZigBee"> wireless ZigBee</a> </p> <a href="https://publications.waset.org/abstracts/49856/radio-frequency-identification-rfid-based-smart-helmet-for-coal-miners" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49856.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">455</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Carbon Coated Yarn Supercapacitors: Parametric Study of Performance Output</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Imtiaz%20Ahmed%20Khan">Imtiaz Ahmed Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Sabu%20John"> Sabu John</a>, <a href="https://publications.waset.org/abstracts/search?q=Sania%20Waqar"> Sania Waqar</a>, <a href="https://publications.waset.org/abstracts/search?q=Lijing%20Wang"> Lijing Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Mac%20Fergusson"> Mac Fergusson</a>, <a href="https://publications.waset.org/abstracts/search?q=Ilija%20Najdovski"> Ilija Najdovski</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Evolution of textiles, from its orthodox to more interactive role has stirred the researchers to uncover its application in numerous arenas. The idea of using textile based materials for wearable energy harvesting and storage devices have gained immense popularity. This is mainly due to textile comfort and flexibility features. In this work, nano-carbonous materials were infused on cellulosic fibers using caustic soda treatment. This paper presents the complete procedure of yarn supercapacitors fabrication process through dip coating technique and its characterization method. The main objective is to study, the effect of varying caustic soda concentration on mass loading of activated carbon on yarns and the related capacitance output of the designed yarn supercapacitor. Polyvinyl alcohol and Phosphoric acid were used as electrolyte in a two-electrode cell assembly to measure device electrochemical performance. The results show a promising increase in capacitance value using this technique. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=yarn%20supercapacitors" title="yarn supercapacitors">yarn supercapacitors</a>, <a href="https://publications.waset.org/abstracts/search?q=activated%20carbon" title=" activated carbon"> activated carbon</a>, <a href="https://publications.waset.org/abstracts/search?q=dip%20coating" title=" dip coating"> dip coating</a>, <a href="https://publications.waset.org/abstracts/search?q=caustic%20soda" title=" caustic soda"> caustic soda</a>, <a href="https://publications.waset.org/abstracts/search?q=electrolyte" title=" electrolyte"> electrolyte</a>, <a href="https://publications.waset.org/abstracts/search?q=electrochemical%20characterization" title=" electrochemical characterization"> electrochemical characterization</a> </p> <a href="https://publications.waset.org/abstracts/72846/carbon-coated-yarn-supercapacitors-parametric-study-of-performance-output" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72846.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">462</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Financial Risk Tolerance and Its Impact on Terrorism-Tourism Relation in Pakistan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sania%20Sana">Sania Sana</a>, <a href="https://publications.waset.org/abstracts/search?q=Afnan%20Nasim"> Afnan Nasim</a>, <a href="https://publications.waset.org/abstracts/search?q=Usman%20Malik"> Usman Malik</a>, <a href="https://publications.waset.org/abstracts/search?q=Maroof%20Tahir"> Maroof Tahir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this research is to scrutinize the interdependent relationship between terrorism and behavioral changes in the tourism activities in Pakistan with the moderating impact of a unique variable titled 'Financial Risk Tolerance'. The article looks at the inter-reliant relationship with the alleged political and economic aspects and behavioral changes in the tourists and the consumers by these variables over time. The researchers used many underlying theories like the catastrophe theory by (Svyantek, Deshon and Siler 1991), information integration theory (Anderson 1981, 1982) and prospect theory (Kahneman and Tversky 1979) to shape the study’s framework as per tourist decision making model. A sample of around 110 locals was used for this purpose and the data was gathered by convenience sampling. The responses were analyzed using regression analysis. The results exhibited how terrorism along with the influence of financial risk tolerance had inclined a behavioral shift in the travelling patterns and vacation destination choice of the local tourists. Lastly, the paper proposes a number of suggestive measures for the tourism industry and the legislative bodies to ensure the safety of travelers and to boost the tourist activities in the vacation industry of Pakistan. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=terrorism" title="terrorism">terrorism</a>, <a href="https://publications.waset.org/abstracts/search?q=tourism" title=" tourism"> tourism</a>, <a href="https://publications.waset.org/abstracts/search?q=financial%20risk%20tolerance" title=" financial risk tolerance"> financial risk tolerance</a>, <a href="https://publications.waset.org/abstracts/search?q=tourist%20decision-making" title=" tourist decision-making"> tourist decision-making</a>, <a href="https://publications.waset.org/abstracts/search?q=destination%20choice" title=" destination choice"> destination choice</a> </p> <a href="https://publications.waset.org/abstracts/87733/financial-risk-tolerance-and-its-impact-on-terrorism-tourism-relation-in-pakistan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/87733.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">236</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> To Identify the Importance of Telemedicine in Diabetes and Its Impact on Hba1c</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sania%20Bashir">Sania Bashir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A promising approach to healthcare delivery, telemedicine makes use of communication technology to reach out to remote regions of the world, allowing for beneficial interactions between diabetic patients and healthcare professionals as well as the provision of affordable and easily accessible medical care. The emergence of contemporary care models, fueled by the pervasiveness of mobile devices, provides better information, offers low cost with the best possible outcomes, and is known as digital health. It involves the integration of collected data using software and apps, as well as low-cost, high-quality outcomes. The goal of this study is to assess how well telemedicine works for diabetic patients and how it impacts their HbA1c levels. A questionnaire-based survey of 300 diabetics included 150 patients in each of the groups receiving usual care and via telemedicine. A descriptive and observational study that lasted from September 2021 to May 2022 was conducted. HbA1c has been gathered for both categories every three months. A remote monitoring tool has been used to assess the efficacy of telemedicine and continuing therapy instead of the customary three monthly meetings like in-person consultations. The patients were (42.3) 18.3 years old on average. 128 men were outnumbered by 172 women (57.3% of the total). 200 patients (66.6%) have type 2 diabetes, compared to over 100 (33.3%) candidates for type 1. Despite the average baseline BMI being within normal ranges at 23.4 kg/m², the mean baseline HbA1c (9.45 1.20) indicates that glycemic treatment is not well-controlled at the time of registration. While patients who use telemedicine experienced a mean percentage change of 10.5, those who visit the clinic experienced a mean percentage change of 3.9. Changes in HbA1c are dependent on several factors, including improvements in BMI (61%) after 9 months of research and compliance with healthy lifestyle recommendations for diet and activity. More compliance was achieved by the telemedicine group. It is an undeniable reality that patient-physician communication is crucial for enhancing health outcomes and avoiding long-term issues. Telemedicine has shown its value in the management of diabetes and holds promise as a novel technique for improved clinical-patient communication in the twenty-first century. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=digital%20health" title=" digital health"> digital health</a>, <a href="https://publications.waset.org/abstracts/search?q=mobile%20app" title=" mobile app"> mobile app</a>, <a href="https://publications.waset.org/abstracts/search?q=telemedicine" title=" telemedicine"> telemedicine</a> </p> <a href="https://publications.waset.org/abstracts/168728/to-identify-the-importance-of-telemedicine-in-diabetes-and-its-impact-on-hba1c" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168728.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">91</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Genotypic and Allelic Distribution of Polymorphic Variants of Gene SLC47A1 Leu125Phe (rs77474263) and Gly64Asp (rs77630697) and Their Association to the Clinical Response to Metformin in Adult Pakistani T2DM Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sadaf%20Moeez">Sadaf Moeez</a>, <a href="https://publications.waset.org/abstracts/search?q=Madiha%20Khalid"> Madiha Khalid</a>, <a href="https://publications.waset.org/abstracts/search?q=Zoya%20Khalid"> Zoya Khalid</a>, <a href="https://publications.waset.org/abstracts/search?q=Sania%20Shaheen"> Sania Shaheen</a>, <a href="https://publications.waset.org/abstracts/search?q=Sumbul%20Khalid"> Sumbul Khalid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Inter-individual variation in response to metformin, which has been considered as a first line therapy for T2DM treatment is considerable. In the current study, it was aimed to investigate the impact of two genetic variants Leu125Phe (rs77474263) and Gly64Asp (rs77630697) in gene <em>SLC47A1</em> on the clinical efficacy of metformin in T2DM Pakistani patients. Methods: The study included 800 T2DM patients (400 metformin responders and 400 metformin non-responders) along with 400 ethnically matched healthy individuals. The genotypes were determined by allele-specific polymerase chain reaction. <em>In-silico</em> analysis was done to confirm the effect of the two SNPs on the structure of genes. Association was statistically determined using SPSS software. Results: Minor allele frequency for rs77474263 and rs77630697 was 0.13 and 0.12. For <em>SLC47A1 </em>rs77474263 the homozygotes of one mutant allele ‘T’ (CT) of rs77474263 variant were fewer in metformin responders than metformin non-responders (29.2% vs. 35.5 %). Likewise, the efficacy was further reduced (7.2% vs. 4.0 %) in homozygotes of two copies of ‘T’ allele (TT). Remarkably, T2DM cases with two copies of allele ‘C’ (CC) had 2.11 times more probability to respond towards metformin monotherapy. For <em>SLC47A1 </em>rs77630697 the homozygotes of one mutant allele ‘A’ (GA) of rs77630697 variant were fewer in metformin responders than metformin non-responders (33.5% vs. 43.0 %). Likewise, the efficacy was further reduced (8.5% vs. 4.5%) in homozygotes of two copies of ‘A’ allele (AA). Remarkably, T2DM cases with two copies of allele ‘G’ (GG) had 2.41 times more probability to respond towards metformin monotherapy. <em>In-silico</em> analysis revealed that these two variants affect the structure and stability of their corresponding proteins. Conclusion: The present data suggest that <em>SLC47A1 </em>Leu125Phe (rs77474263) and Gly64Asp (rs77630697) polymorphisms were associated with the therapeutic response of metformin in T2DM patients of Pakistan. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=T2DM" title=" T2DM"> T2DM</a>, <a href="https://publications.waset.org/abstracts/search?q=SLC47A1" title=" SLC47A1"> SLC47A1</a>, <a href="https://publications.waset.org/abstracts/search?q=Pakistan" title=" Pakistan"> Pakistan</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism"> polymorphism</a> </p> <a href="https://publications.waset.org/abstracts/105468/genotypic-and-allelic-distribution-of-polymorphic-variants-of-gene-slc47a1-leu125phe-rs77474263-and-gly64asp-rs77630697-and-their-association-to-the-clinical-response-to-metformin-in-adult-pakistani-t2dm-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/105468.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">159</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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