CINXE.COM

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</div> <div id="search_results" class="col-xs-12 col-sm-4 col-md-9"> <div class="search_mobile_buttons" style="display: none;"> <div class="search_filters_toggle btn btn-secondary">Filter Results</div> </div>  <div class="tabbed_content"> <div class="tab_content tab_1 tab_open"> <div class="search_results_block"> <div class="search_results_top"> <div class="search_header_text"><div class="et-search-content-commonname"><h1>Jak2: Products</h1><p>Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands.<span class="text_more collapsed"> Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.<br /><br />Jak1 is required for the activation of STAT1 and STAT2 in response to interferon. Jak2 plays an essential role in interferon gamma signaling. Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins. Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID).</span></p> <div class="cnsp-show-more-wrapper"><div class="cnsp-show-more collapsed">Show More</div></div> </div></div> <div class="search_header"> "<span class="search_term">Jak2</span>" has 14 results in Products. </div> <div class="search_type"> Sort by: <div class="select_wrapper"><select id="search_type_select">'; <option value="/target/jak2?sort=ranking,desc" selected="selected"> Best Match </option> <option value="/target/jak2?sort=product_title,asc"> Products (A-Z) </option> <option value="/target/jak2?sort=product_added,desc"> Newest </option> <option value="/target/jak2?sort=stars,desc"> Rating </option> </select></div>  </div>  </div>  <div class="cnsp-result search_result search_product"> <h2><a href="/products/u0126_1144" class="ecommerce_link" data-id="1144" data-variant="1144/5,1144/25" data-search_type="target_search" data-position="1" data-brand="tocris" data-name="U0126" data-category="Small Molecules" data-sub_category="Tocris Small Molecules" data-sub_category_id="130" data-price="284" data-currency_code="USD">U0126</a> </h2> <div class="cnsp-description"> Potent, selective inhibitor of MEK1 and 2 </div> <div class="cnsp_content"> <div class="cnsp_table"> <div class="cnsp_table_row"> <div class="cnsp_meta"> <div class="cnsp_catnum"><a href="/products/u0126_1144">1144</a></div> <div class="cnsp_citations"><a href="/products/u0126_1144#product-citations">131 Citations</a></div> <div class="cnsp_reviews"><a href="/products/u0126_1144#product-reviews"><span class="searchImage_star5"></span> 5 Reviews</a></div> </div> <div class="cnsp_buttons"> <div class="btn btn-septenary show_sizes_button collapsed">Show Size & Price</div> </div> </div> </div> <div class="cnsp_atc_wrapper"> <div class="add_to_cart_block collapsed" data-skus="1144/5,1144/25" data-skus_split="4" data-basesku="1144" data-title="U0126" style="display:none;"></div> </div> </div> </div> <div class="cnsp-result search_result search_product"> <h2><a href="/products/cp-690550-citrate_4556" class="ecommerce_link" data-id="4556" data-variant="4556/10,4556/50" data-search_type="target_search" data-position="2" data-brand="tocris" data-name="CP 690550 citrate" data-category="Small Molecules" data-sub_category="Tocris Small Molecules" data-sub_category_id="130" data-price="243" data-currency_code="USD">CP 690550 citrate</a> </h2> <div class="cnsp-description"> Potent JAK inhibitor </div> <div class="cnsp_content"> <div class="cnsp_table"> <div class="cnsp_table_row"> <div class="cnsp_meta"> <div class="cnsp_catnum"><a href="/products/cp-690550-citrate_4556">4556</a></div> <div class="cnsp_citations"><a href="/products/cp-690550-citrate_4556#product-citations">6 Citations</a></div> <div class="cnsp_reviews"><a href="/products/cp-690550-citrate_4556#product-reviews"><span class="searchImage_star5"></span> 1 Review</a></div> </div> <div class="cnsp_buttons"> <div class="btn btn-septenary show_sizes_button collapsed">Show Size & Price</div> </div> </div> </div> <div class="cnsp_atc_wrapper"> <div class="add_to_cart_block collapsed" data-skus="4556/10,4556/50" data-skus_split="4" data-basesku="4556" data-title="CP 690550 citrate" style="display:none;"></div> </div> </div> </div> <div class="cnsp-result search_result search_product"> <h2><a href="/products/ag-490_0414" class="ecommerce_link" data-id="0414" data-variant="0414/10,0414/50" data-search_type="target_search" data-position="3" data-brand="tocris" data-name="AG 490" data-category="Small Molecules" data-sub_category="Tocris Small Molecules" data-sub_category_id="130" data-price="155" data-currency_code="USD">AG 490</a> </h2> <div class="cnsp-description"> EGFR-kinase inhibitor. 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