Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="0GSKdsyZgDMX2A7Um1ad3eIisehJIPjNUVoUZgDb5qnmKUxGqgm1vhSxfLjDCz7h"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="0GSKdsyZgDMX2A7Um1ad3eIisehJIPjNUVoUZgDb5qnmKUxGqgm1vhSxfLjDCz7h"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="0GSKdsyZgDMX2A7Um1ad3eIisehJIPjNUVoUZgDb5qnmKUxGqgm1vhSxfLjDCz7h"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="0GSKdsyZgDMX2A7Um1ad3eIisehJIPjNUVoUZgDb5qnmKUxGqgm1vhSxfLjDCz7h"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="15113924"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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class="period">. </span><span class="cit">2004 May;78(10):5458-65.</span> </div> <span class="citation-doi"> doi: 10.1128/jvi.78.10.5458-5465.2004. </span> </div> <h1 class="heading-title"> Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Garbutt+M&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael Garbutt">Michael Garbutt</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Special Pathogens Program, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Liebscher+R&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ryan Liebscher">Ryan Liebscher</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wahl-Jensen+V&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Victoria Wahl-Jensen">Victoria Wahl-Jensen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jones+S&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Steven Jones">Steven Jones</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=M%C3%B6ller+P&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Peggy Möller">Peggy Möller</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wagner+R&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ralf Wagner">Ralf Wagner</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Volchkov+V&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Viktor Volchkov">Viktor Volchkov</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Klenk+HD&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hans-Dieter Klenk">Hans-Dieter Klenk</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Feldmann+H&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Heinz Feldmann">Heinz Feldmann</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Str%C3%B6her+U&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ute Ströher">Ute Ströher</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/15113924/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Special Pathogens Program, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">15113924</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC400370&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC400370/" data-ga-category="full_text" data-ga-action="PMCID" > PMC400370 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1128/jvi.78.10.5458-5465.2004&id_type=DOI" href="https://doi.org/10.1128/jvi.78.10.5458-5465.2004" 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class="authors-list-item "><a class="full-name" href="/?term=Garbutt+M&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael Garbutt">Michael Garbutt</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Special Pathogens Program, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Liebscher+R&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ryan Liebscher">Ryan Liebscher</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wahl-Jensen+V&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Victoria Wahl-Jensen">Victoria Wahl-Jensen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jones+S&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Steven Jones">Steven Jones</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=M%C3%B6ller+P&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Peggy Möller">Peggy Möller</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wagner+R&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ralf Wagner">Ralf Wagner</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Volchkov+V&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Viktor Volchkov">Viktor Volchkov</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Klenk+HD&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hans-Dieter Klenk">Hans-Dieter Klenk</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Feldmann+H&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Heinz Feldmann">Heinz Feldmann</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Str%C3%B6her+U&cauthor_id=15113924" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ute Ströher">Ute Ströher</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Special Pathogens Program, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">15113924</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC400370&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC400370/" data-ga-category="full_text" data-ga-action="PMCID" > PMC400370 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1128/jvi.78.10.5458-5465.2004&id_type=DOI" href="https://doi.org/10.1128/jvi.78.10.5458-5465.2004" data-ga-category="full_text" data-ga-action="DOI" > 10.1128/jvi.78.10.5458-5465.2004 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/15113924/citations/" data-citation-style="nlm" data-pubmed-format-link="/15113924/export/"><span class="button-label">Cite</span></button><button class="more-actions-button 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id="eng-abstract"> <p> Replication-competent recombinant vesicular stomatitis viruses (rVSVs) expressing the type I transmembrane glycoproteins and selected soluble glycoproteins of several viral hemorrhagic fever agents (Marburg virus, Ebola virus, and Lassa virus) were generated and characterized. All recombinant viruses exhibited rhabdovirus morphology and replicated cytolytically in tissue culture. Unlike the rVSVs with an additional transcription unit expressing the soluble glycoproteins, the viruses carrying the foreign transmembrane glycoproteins in replacement of the VSV glycoprotein were slightly attenuated in growth. Biosynthesis and processing of the foreign glycoproteins were authentic, and the cell tropism was defined by the transmembrane glycoprotein. None of the rVSVs displayed pathogenic potential in animals. The rVSV expressing the Zaire Ebola virus transmembrane glycoprotein mediated protection in mice against a lethal Zaire Ebola virus challenge. Our data suggest that the recombinant VSV can be used to study the role of the viral glycoproteins in virus replication, immune response, and pathogenesis. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="fig-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/81dd13793f2d/zjv0100423760001.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="604" data-image-height="459" data-image-alt="FIG. 1." data-pmc-id="PMC400370" data-figure-id="f1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/0423363b6e32/zjv0100423760001.gif" alt="FIG. 1." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="604"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="459"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 1. </p> </strong> <div class="figure-caption-contents"><p> Schematic drawing of the infectious… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 1. </p> </strong> <div class="figure-caption-contents"><p> Schematic drawing of the infectious clone system for VSV, Indiana serotype. BSR-T7 cells… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 1. </strong> <div class="figure-caption-contents">Schematic drawing of the infectious clone system for VSV, Indiana serotype. BSR-T7 cells were cotransfected with a plasmid containing the VSV genome (VSVXN2 or VSVXN2ΔG) and plasmids expressing the VSV nucleoprotein (pBS-VSV N), phosphoprotein (pBS-VSV P), or polymerase (pBS-VSV L). Transcription of all plasmids is under the control of the bacteriophage T7 RNA promoter. For this study, the glycoproteins of Zaire Ebola virus (ZEBOV GP), Marburg virus (MARV GP), and Lassa virus (LASV GPC) were inserted between the VSV matrix and polymerase (L) genes by using plasmid VSVXN2ΔG (A). In addition, Zaire Ebola virus sGP and Marburg virus GP<sub>1</sub> were inserted as an additional gene into vector VSVXN2 (B).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/30a4553c1fa5/zjv0100423760002.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="528" data-image-height="535" data-image-alt="FIG. 2." data-pmc-id="PMC400370" data-figure-id="f2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/4f536210f481/zjv0100423760002.gif" alt="FIG. 2." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="528"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="535"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 2. </p> </strong> <div class="figure-caption-contents"><p> Characterization of rescued rVSVs. Rescued… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 2. </p> </strong> <div class="figure-caption-contents"><p> Characterization of rescued rVSVs. Rescued rVSVs were used to infect VeroE6 cells at… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 2. </strong> <div class="figure-caption-contents">Characterization of rescued rVSVs. Rescued rVSVs were used to infect VeroE6 cells at an MOI of 0.1 PFU/cell. (A) Cytopathogenic effect of infected VeroE6 cells is shown by phase-contrast microscopy 24 h postinfection with VSVΔG/MARVGP (lower panel) in comparison with a mock-infected culture (upper panels). (B) Particle morphology. Electron micrographs show wild-type VSV (upper panel) and VSVΔG/MARVGP (lower panel). (C) Immunofluorescence staining of VeroE6 cells infected with VSVΔG/MARVGP with the GP-specific monoclonal antibody 5EII (dilution, 1:1,000) (lower panel). The upper panel shows the same cells in bright-field microscopy. (D) Growth curves. VeroE6 cells were infected with wild-type VSV (VSVwt), VSV/ZEBOVsGP, VSV/MARVGP<sub>1</sub>, VSVΔG/ZEBOVGP, VSVΔG/LASVGP, or VSVΔG/MARVGP at an MOI of 10. Supernatants were collected at the indicated times and titrated by defining the TCID<sub>50</sub>.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="fig-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/363427624984/zjv0100423760003.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="519" data-image-height="619" data-image-alt="FIG. 3." data-pmc-id="PMC400370" data-figure-id="f3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/49f46db2e7da/zjv0100423760003.gif" alt="FIG. 3." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="519"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="619"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 3. </p> </strong> <div class="figure-caption-contents"><p> Biosynthesis of the foreign glycoproteins… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 3. </p> </strong> <div class="figure-caption-contents"><p> Biosynthesis of the foreign glycoproteins expressed after infection with rVSVs. VeroE6 cells were… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 3. </strong> <div class="figure-caption-contents">Biosynthesis of the foreign glycoproteins expressed after infection with rVSVs. VeroE6 cells were infected with rVSVs at an MOI of 10. (A) For cells infected with VSVΔG/MARVGP, proteins were pulse labeled at 24 h postinfection for 30 min with 20 μCi of [<sup>35</sup>S]cysteine per ml and chased for 240 min. GP-specific proteins were immunoprecipitated from cell lysates with mouse anti-Marburg virus GP immunoglobulin (II9G4) (dilution, 1:800) and analyzed on SDS-10% PAGE under reducing conditions. The presence of decRVKR (25 μM) during labeling and chase abolished cleavage of pre-GP (lane 2). (B) For cells infected with VSVΔG/EBOVGP, cells were lysed 24 h postinfection and analyzed by Western blotting with a GP<sub>1</sub>-specific antibody at a dilution of 1:4,000 (lane 1) and GP<sub>2</sub>-specific rabbit antiserum at a dilution of 1:2,000 (lane 2). (C) For cells infected with VSVΔG/LASVGPC, cells were lysed 24 h postinfection and analyzed by Western blotting with a GP2-specific antiserum (dilution, 1:2,000). (D) For cells infected with wild-type VSV (VSVwt) (lane 1), VSV/ZEBOVsGP (lane 2), and VSV/MARVGP<sub>1</sub> (lane 3), supernatants were analyzed 12 h postinfection by Western blotting with a VSV G-specific antibody (dilution, 1:1,000), a Zaire Ebola virus GP-specific antibody (12/1.1; dilution, 1:4,000), and a Marburg virus GP<sub>1</sub>-specific antibody (5EII; dilution, 1:4,000).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="fig-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/b75bdb0d8f4d/zjv0100423760004.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="552" data-image-height="423" data-image-alt="FIG. 4." data-pmc-id="PMC400370" data-figure-id="f4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e1/400370/3a4105a39d24/zjv0100423760004.gif" alt="FIG. 4." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="552"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="423"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 4. </p> </strong> <div class="figure-caption-contents"><p> Cell tropism of rVSVs. Jurkat… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 4. </p> </strong> <div class="figure-caption-contents"><p> Cell tropism of rVSVs. Jurkat cells were infected with wild-type VSV (VSVwt), VSVΔG/LASVGPC,… </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 4. </strong> <div class="figure-caption-contents">Cell tropism of rVSVs. Jurkat cells were infected with wild-type VSV (VSVwt), VSVΔG/LASVGPC, or VSVΔG/EBOVGP at an MOI of 10. (A) Virus production. Virus titers for the indicated time points were measured in VeroE6 cells by determining the TCID<sub>50</sub> /ml. (B) Protein expression. At the indicated times, cells and supernatants were harvested, and virus growth was demonstrated by Western blotting with a rabbit serum raised against the VSV nucleoprotein (N) (dilution, 1:2,000). Controls included mock-infected Jurkat cells (upper panel) and VSVΔG/LASVGP-infected VeroE6 cells (lower panel).</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/26109675/" ref="article_id=26109675&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="26109675" data-ga-label=""> Vaccination With a Highly Attenuated Recombinant Vesicular Stomatitis Virus Vector Protects Against Challenge With a Lethal Dose of Ebola Virus. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Matassov D, Marzi A, Latham T, Xu R, Ota-Setlik A, Feldmann F, Geisbert JB, Mire CE, Hamm S, Nowak B, Egan MA, Geisbert TW, Eldridge JH, Feldmann H, Clarke DK.</span> <span class="docsum-authors short-authors">Matassov D, et al.</span> <span class="docsum-journal-citation full-journal-citation">J Infect Dis. 2015 Oct 1;212 Suppl 2(Suppl 2):S443-51. doi: 10.1093/infdis/jiv316. 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Epub 2024 May 29.</span> <span class="docsum-journal-citation short-journal-citation">J Virol. 2024.</span> <span class="citation-part">PMID: <span class="docsum-pmid">38809021</span></span> </div> </div> </li> </ul> <div class="actions-bar"> <a class="show-all-linked-articles" data-href="/?linkname=pubmed_pubmed_citedin&from_uid=15113924" data-ga-category="cited_by" data-ga-action="show_all" > See all "Cited by" articles </a> </div> </div> <div class="references" id="references"> <h2 class="title"> References </h2> <div id='top-references-list' class="references-lists-container"> <div class="refs-list"> <ol id="top-references-list-1" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Bray, M., K. Davis, T. Geisbert, C. Schmaljohn, and J. Huggins. 1998. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. 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Virol. 73:251-259. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC103829/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC103829" > PMC </a> - <a class="reference-link" href="/9847328/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="9847328" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Buchmeier, M. J. 2002. Arenaviruses: protein structure and function. Curr. Top. Microbiol. Immunol. 262:159-173. - <a class="reference-link" href="/11987805/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="11987805" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Buchmeier, M. J., M. D. Bowen, and C. J. Peters. 2001. Arenaviridae: The viruses and their replication, p. 1635-1668. In D. M. Knipe, P. M. Howley, D. E. Griffin, M. A. Martin, R. A. Lamb, and B. Roizman (ed.), Fields virology, vol. 2. Lippincott Williams & Wilkins, Philadelphia, Pa. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Cao, W., M. D. Henry, P. Borrow, H. Yamada, J. H. Elder, E. V. Ravkov, S. T. Nichol, R. W. Compans, K. P. Campbell, and M. B. A. Oldstone. 1998. Identification of dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science 282:2079-2081. - <a class="reference-link" href="/9851928/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="9851928" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-1" data-next-page-url="/15113924/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 53 references </button> </div> </div> </div> </div> <div id="publication-types" class="publication-types keywords-section"> <h2 class="title"> Publication types </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Research Support, Non-U.S. Gov't" tabindex="0" aria-controls="keyword-actions-publication-types-0" aria-expanded="false" data-pinger-ignore> Research Support, Non-U.S. Gov't </button><div 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for keyword Recombinant Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Recombinant+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Recombinant+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Recombinant Proteins"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Recombinant Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Recombinant+Proteins%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Recombinant Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Recombinant Proteins"[nm]" data-ga-category="search" 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Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses - PubMed