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[{"id":41735206,"identifier":"Attachment_41735206","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":21145145,"created_at":"2016-01-29T07:44:40.570-08:00","from_world_paper_id":147455676,"updated_at":"2024-11-13T13:56:21.099-08:00","_data":{"grobid_abstract":"We used flow cytometry to analyze the cell cycle, DNA damage, and apoptosis in hematopoietic subsets in MDS marrow. Subsets were assigned using CD45, side scatter, CD34, and CD71. Cell cycle fractions were analyzed using DRAQ 5 (DNA content) and MPM-2 (mitoses). DNA damage was assessed using p-H2A.X, and apoptosis using Annexin V. Compared to controls, MDS patients demonstrated no increased mitoses in erythroid, myeloid, or CD34+ cells. Myeloid progenitors demonstrated increased G2 cells, which with no increased mitoses suggested delayed passage through G2. Myeloid progenitors demonstrated increased p-H2A.X, consistent with DNA damage causing this delay. Annexin V reactivity was equivalent in MDS and controls. Results for each parameter varied among hematopoietic compartments, demonstrating the need to analyze compartments separately. Our results suggest that peripheral cytopenias in MDS are due to delayed cell cycle passage of marrow progenitors and that this delayed passage and leukemic progression derive from excessive DNA damage.","publication_date":"2011,,","publication_name":"Bone Marrow Research","grobid_abstract_attachment_id":"41735206"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [42330984]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 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cause-effect relationship</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="59016863" href="https://independent.academia.edu/AGAPIPARCHARIDOU">AGAPI PARCHARIDOU</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Leukemia & lymphoma, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">The paradox of pancytopenia despite cellular bone marrows (BM) was investigated in 120 patients with myelodysplastic syndromes (MDS). 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class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/34627509/Myelodysplastic_syndromes_an_update_on_molecular_pathology"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="24373270" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24373270/Cytogenetic_clonality_analysis_typical_patterns_in_myelodysplastic_syndrome_and_acute_myeloid_leukaemia">Cytogenetic clonality analysis: typical patterns in myelodysplastic syndrome and acute myeloid leukaemia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46989275" href="https://independent.academia.edu/PhilippeVandekerckhove">Philippe Vandekerckhove</a></div><p class="ds-related-work--metadata ds2-5-body-xs">British Journal of Haematology, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytogenetic clonality analysis: typical patterns in myelodysplastic syndrome and acute myeloid leukaemia","attachmentId":44704629,"attachmentType":"pdf","work_url":"https://www.academia.edu/24373270/Cytogenetic_clonality_analysis_typical_patterns_in_myelodysplastic_syndrome_and_acute_myeloid_leukaemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24373270/Cytogenetic_clonality_analysis_typical_patterns_in_myelodysplastic_syndrome_and_acute_myeloid_leukaemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="82639663" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/82639663/Apoptosis_in_bone_marrow_biopsy_samples_involving_stromal_and_hematopoietic_cells_in_50_patients_with_myelodysplastic_syndromes_see_comments_">Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes [see comments]</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="59016863" href="https://independent.academia.edu/AGAPIPARCHARIDOU">AGAPI PARCHARIDOU</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Blood, 1995</p><p class="ds-related-work--abstract ds2-5-body-sm">Cell-cycle kinetics were measured in situ after infusions of iododeoxyuridine and/or bormodeoxyuridine in 50 patients with myelodysplastic syndromes (MDS) and the median labeling index in bone marrow (BM) biopsy samples was 28.6%. Unfortunately, 26 of 50 patients showed that &gt; or = 75% of hematopoietic cells of all three lineages were undergoing programmed cell death (PCD) in their biopsy samples as shown by the in situ end labeling (ISEL) technique. Ten patients had 1/3 and eight had 2/3 ISEL+ cells. Stromal cells were frequently ISEL+ and often S-phase cells were also found to be simultaneously ISEL+. Nucleosomal DNA fragments as a ladder in agarose gel were present in BM aspirates of four patients who showed high ISEL and were absent in two who had no ISEL staining in biopsy samples, but only when DNA was extracted after a 4-hour in vitro incubation in complete medium. Therefore, laddering data confirmed the ISEL findings that the majority of hematopoietic cells in MDS are in ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes [see comments]","attachmentId":88280068,"attachmentType":"pdf","work_url":"https://www.academia.edu/82639663/Apoptosis_in_bone_marrow_biopsy_samples_involving_stromal_and_hematopoietic_cells_in_50_patients_with_myelodysplastic_syndromes_see_comments_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/82639663/Apoptosis_in_bone_marrow_biopsy_samples_involving_stromal_and_hematopoietic_cells_in_50_patients_with_myelodysplastic_syndromes_see_comments_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="55309963" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55309963/Increased_apoptosis_of_bone_marrow_cells_and_preserved_proliferative_capacity_of_selected_progenitors_predict_for_clinical_response_to_anti_inflammatory_therapy_in_myelodysplastic_syndromes">Increased apoptosis of bone marrow cells and preserved proliferative capacity of selected progenitors predict for clinical response to anti-inflammatory therapy in myelodysplastic syndromes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43300890" href="https://independent.academia.edu/CecileduToit">Cecile du Toit</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Experimental Hematology, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Increased apoptosis of bone marrow cells and preserved proliferative capacity of selected progenitors predict for clinical response to anti-inflammatory therapy in myelodysplastic 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class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="88124031" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/88124031/Cytogenetic_abnormalities_in_myelodysplastic_syndrome_an_overview">Cytogenetic abnormalities in myelodysplastic syndrome: an overview</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="180089905" href="https://independent.academia.edu/umairmalik140">umair malik</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hematology, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytogenetic abnormalities in myelodysplastic syndrome: an 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Yuan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Laboratory Hematology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Myelodysplastic syndromes: the role of flow cytometry in diagnosis and prognosis","attachmentId":112786396,"attachmentType":"pdf","work_url":"https://www.academia.edu/116741369/Myelodysplastic_syndromes_the_role_of_flow_cytometry_in_diagnosis_and_prognosis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/116741369/Myelodysplastic_syndromes_the_role_of_flow_cytometry_in_diagnosis_and_prognosis"><span 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