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COF-Based Nanomaterials for Vaccine Storage and Transport – Vaccine Studies
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id="primary"> <main class="site-main" id="main"> <article id="post-73" class="post-73 post type-post status-publish format-standard has-post-thumbnail hentry category-vaccine-storage tag-cofs tag-covid-19-vaccines tag-exosome tag-hydrophobic tag-lipid tag-mrna tag-nanocarriers tag-nanoparticles tag-nanovaccine tag-vaccine-storage tag-vaccine-transport tag-vaccine-transportation" itemtype="https://schema.org/CreativeWork" itemscope> <div class="inside-article"> <div class="featured-image page-header-image-single "> <img width="1200" height="628" src="https://vaccine-studies.com/archive/wp-content/uploads/2024/09/banner-02-min-scaled-e1727521783886.jpg" class="attachment-full size-full" alt="" itemprop="image" decoding="async" fetchpriority="high" /> </div> <header class="entry-header"> <h1 class="entry-title" itemprop="headline">COF-Based Nanomaterials for Vaccine Storage and Transport</h1> <div class="entry-meta"> <span class="posted-on"><time class="updated" datetime="2024-09-28T16:39:50+05:30" itemprop="dateModified">September 28, 2024</time><time class="entry-date published" datetime="2024-09-28T12:22:48+05:30" itemprop="datePublished">September 28, 2024</time></span> <span class="byline">by <span class="author vcard" itemprop="author" itemtype="https://schema.org/Person" itemscope><a class="url fn n" href="https://vaccine-studies.com/archive/author/vaccine-studies/" title="View all posts by vaccine-studies" rel="author" itemprop="url"><span class="author-name" itemprop="name">vaccine-studies</span></a></span></span> </div> </header> <div class="entry-content" itemprop="text"> <p><span style="font-weight: 400;">The field of vaccines has witnessed some ground-breaking changes in the recent past. More specifically, in the context of developing and disseminating vaccines, the stability of the same remains of paramount importance. Traditional methodologies have mostly and massively thrown challenges with due respect to cold chain, degradation issues, and delivery of the vaccine to the destination in an intact form and an effective manner. Recently, Covalent Organic Frameworks have popped as one of the solutions to such challenges. COFs are porous, crystalline materials with highly tunable structures and functionalities that pose them as ideal candidates for a variety of biomedical applications. This review discusses the application of such materials in the storage and transportation of vaccines and provides the prospects for revolutionizing the area, where more reliable and efficient distribution of vaccines can be ensured.</span></p> <h3><b>Overview of COFs</b></h3> <p><span style="font-weight: 400;">COFs are a class of materials that exhibit an extremely large surface area, low density, and tunable porosity. They are constructed from the self-condensation of organic molecules through strong covalent bonds, forming highly stable frameworks. Considering the attributes of tunability of pore sizes, chemical stability, and functionalizability, COF-based materials are particularly interestable for biomedical applications in the areas of drug delivery and diagnostics, and even in vaccine storage and transport.</span></p> <h3><b>Improving Vaccine Stability</b></h3> <p><span style="font-weight: 400;">Vaccines, in particular, suffer from one important distribution problem: the stability of the vaccine while it is stored or transported. Many vaccines, especially mRNA-based and live attenuated virus-based ones, are highly susceptible to changes in temperature and may degrade very fast without proper storage conditions. The COF-based nanomaterials do so by offering a protective environment that safeguards the vaccine against unfavorable conditions.</span></p> <p><span style="font-weight: 400;">COFs are synthesized through specific pore sizes and surface functionalities, which confine the vaccine molecules and do not allow degradation. The interior of some COFs has moisture due to its hydrophobic character, whereas others have hydrophilic surfaces that resist the aggregation and denaturation of proteins. A large surface area promotes adsorption of stabilizing agents, which provides further stability to the encapsulated vaccines.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Yearwise Publication Trend on <b>“<a href="https://vaccine-studies.com/publication-trends/index/vaccine storage" target="_blank" title="vaccine storage - yearwise publication trends">vaccine storage</a>”</b></h2> </div> </div><div class="results-container"><div class="chart-block" style="padding:15px;"> <div class="left"> <div id="results" class="results"></div> </div> <div class="right"> <div class="chart-container"><canvas id="publicationChart"></canvas></div> </div> <div class="keywordsdiv"> <div style="text-align:center;"><b>Find publication trends on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-stats"></span> </div> </div></div></div><div class="inside-article"><style> table { margin: 0 0 1.5em; 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The porous nature of these materials makes them excellent thermal insulators, hence enhancing temperature-controlled storage for COF-based nanomaterials. Such materials can offer an excellent barrier to heat transfer, creating a uniform temperature if the external conditions are varied.</span></p> <p><span style="font-weight: 400;">Apart from that, COFs can be functionalized with PCMs that absorb or release heat at certain temperatures. These PCMs have the potential to regulate the temperature within the COF structure to prevent the vaccines encapsulated therein from becoming destroyed during transportation. This is a very big value addition in keeping those vaccines that are ultra-low temperature-sensitive, like some of the newly developed COVID-19 vaccines, in a condition for use.</span></p> <h3><b>Prevention of Vaccine Degradation</b></h3> <p><span style="font-weight: 400;">Light, oxygen, and humidity are potential factors within the environment that can degrade vaccines during storage and transportation. In this respect, COF-based nanomaterials could be designed to exclude such degradative elements. For example, COFs possessing UV-absorbing or oxygen-scavenging functionalities prevent photodegradation and oxidative damage to the vaccine.</span></p> <p><span style="font-weight: 400;">Further, the encapsulation of vaccines in COF nanomaterials should protect them from exposure to humidity, which is very common and always results in the degradation of vaccines. In other words, the high porosity of COFs provides a means for adsorption of moisture and hence can keep the encapsulated vaccines dry and stable. Such control over moisture content becomes very critical for the integrity of vaccines as storage extends and transportation periods are longer.</span></p> <h3><b>Improved vaccine delivery efficiency</b></h3> <p><span style="font-weight: 400;">Besides storage and transport, COF-based nanomaterials present potential benefits in the delivery of vaccines. Owing to the high surface area and tunable pore sizes available in COFs, high loadings and controlled release of vaccine molecules can be achieved. Controlled release, therefore, allows the vaccine to be administered at the optimal dosages and rates for maximum impact.</span></p> <p><span style="font-weight: 400;">In addition, COFs can be tailored according to their structure to precisely focus on particular cells or tissue types for the fine-tuning of vaccine delivery to specific locations of interest. Functionalization with targeting ligands or antibodies is capable of guiding COF encapsulation vaccines to immune cells, therefore ensuring a robust and specific immune response. In this context, targeted delivery not only results in improved vaccine efficacy but also reduced dosing, thereby garnering a decrease in the number of side effects.</span></p> <h3><b>Case Studies and Applications</b></h3> <p><span style="font-weight: 400;">A number of studies are emerging on the opportunity to use COF-based nanomaterials for vaccine storage and transport. For instance, COFs can be designed with favorable functional groups so that they will interact and hold protein-based vaccines. These COFs are also designed in such a way that not only do they protect the vaccine from environmental degradation, but they also enhance immunogenicity by presenting the antigens in a highly ordered and accessible manner.</span></p> <p><span style="font-weight: 400;">In the literature, in yet another study, COFs by the encapsulation of mRNA vaccines were prepared, whereby very fragile molecules, mRNA vaccines, were protected from enzymatic degradation yet delivered efficiently into the target cell. The COF-delivered mRNA vaccines showed enhanced stability and immunogenicity compared to traditional lipid-based delivery systems.</span></p> <p><span style="font-weight: 400;">It has also been explored that COFs could serve as delivery vectors for live attenuated vaccines. They provide a preserving medium, which will maintain their viability, stability, and infectivity during storage and transportation. Both high surface area and tunable porosity of COFs result in efficient encapsulation and release of the live virus, assuring its stability and efficacy at administration.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Recent Publications on <b>“<a href="https://vaccine-studies.com/recent-publications/index/vaccine storage" target="_blank" rel="noopener" title="vaccine storage - yearwise publication list">vaccine storage</a>”</b></h2> </div> </div> <div class="pb-main"><div class="article-scroll"><div id="results_recent" class="results"></div></div><div class="keywordsdiv" style="margin: 0px 15px;margin-top:20px;"> <div style="text-align:center;"><b>Find publications on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 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<script> function decodeString(str) { str = str.replace(/\\'/g, "'"); str = str.replace(/\\'/g, "'"); str = str.replace(/\\'/g, "'"); return str; } function displayResults_recent(papers) { var resultsContainer = document.getElementById('results_recent'); if (!papers || papers.length === 0) { resultsContainer.innerHTML = '<p>No recent publications found.</p>'; return; } papers.forEach(paper => { var publicationBlock = document.createElement('div'); publicationBlock.className = 'publication-block'; var title_de = decodeString(paper.title); var publicationHTML = ` <div style="margin-bottom: 10px;line-height: 24px;"><a href="${paper.url}" target="_blank" title="${title_de}">${title_de}</a></div> <p><strong>Issue Release:</strong> ${paper.publishedDate}</p> `; publicationBlock.innerHTML = publicationHTML; resultsContainer.appendChild(publicationBlock); }); } function displayKeywordPapers(keywords) { var resultsContainer = document.getElementById('keyword-papers'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach((key, index) => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://vaccine-studies.com/recent-publications/index/${key_replace}" target="_blank" title="${key} - publication list">${key}</a>`; if (index < keywords.length - 1) { keywordHTML += ', '; } }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var recent_papers = [ { "title": "Costs of in- and outpatient respiratory disease and the seasonal influenza vaccination program in Armenia - 2020-2021.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38839517", "publishedDate": "2024" }, { "title": "Evaluating the Compatibility of New Recombinant Protein Antigens (Trivalent NRRV) with a Mock Pentavalent Combination Vaccine Containing Whole-Cell Pertussis: Analytical and Formulation Challenges.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38932338", "publishedDate": "2024" }, { "title": "Computational design and investigation of the monomeric spike SARS-CoV-2-ferritin nanocage vaccine stability and interactions.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38933369", "publishedDate": "2024" }, { "title": "Water-Soluble and Freezable Aluminum Salt Vaccine Adjuvant.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38932410", "publishedDate": "2024" }, { "title": "Individualized Multimodal Immunotherapy (IMI): Scientific Rationale and Clinical Experience from a Single Institution.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38672110", "publishedDate": "2024" }, { "title": "Calcium Chloride as a Novel Stabilizer for Foot-and-Mouth Disease Virus and Its Application in the Vaccine Formulation.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38675749", "publishedDate": "2024" }, { "title": "Statistical Experimental Designs for cLTB-Syn Vaccine Production Using Daucus carota Cell Suspension Cultures.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38698590", "publishedDate": "2024" }, { "title": "Promotion of Th17 Polarized Immunity via Co-Delivery of Mincle Agonist and Tuberculosis Antigen Using Silica Nanoparticles.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38832760", "publishedDate": "2024" }, { "title": "Clinical and Preclinical Methods of Heat-Stabilization of Human Vaccines.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38288698", "publishedDate": "2024" }, { "title": "Protein subunit vaccines: Promising frontiers against COVID-19.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38219913", "publishedDate": "2024" }, { "title": "Silk Fibroin-Coated Nano-MOFs Enhance the Thermal Stability and Immunogenicity of HBsAg.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38323561", "publishedDate": "2024" }, { "title": "Screening and Stability Evaluation of Freeze-Dried Protective Agents for a Live Recombinant Pseudorabies Virus Vaccine.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38250878", "publishedDate": "2024" }, { "title": "Development and Immunological Evaluation of a Multiantigen Thermostable Nanovaccine Adjuvanted with T-Cell-Activating Scaffold for African Swine Fever.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38346262", "publishedDate": "2024" }, { "title": "The cost of human papillomavirus vaccination delivery at the administrative and health facility levels in the Philippines.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38420134", "publishedDate": "2024" }, { "title": "Biophysical and biochemical characterization of a recombinant lyme disease vaccine antigen, CspZ-YA.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38211914", "publishedDate": "2024" }, { "title": "Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- and multi-valent adjuvanted glycoprotein vaccines.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38458540", "publishedDate": "2024" }, { "title": "Internet of Things (IoT)-enabled framework for a sustainable Vaccine cold chain management system.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38586317", "publishedDate": "2024" }, { "title": "Effects of Shock and Vibration on Product Quality during Last-Mile Transportation of Ebola Vaccine under Refrigerated Conditions.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38526137", "publishedDate": "2024" }, { "title": "Acceptability, cost-effectiveness, and capacity of a facility-based seasonal influenza vaccination among high-risk groups: a study protocol in selected tertiary care hospitals of Bangladesh.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38245668", "publishedDate": "2024" }, { "title": "Mutations in the F protein of the live-attenuated respiratory syncytial virus vaccine candidate \u0394NS2\/\u03941313\/I1314L increase the stability of infectivity and content of prefusion F protein.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38593167", "publishedDate": "2024" } ]; var keywordsArray = ["Covalent Organic Frameworks","COFs","vaccine storage","vaccine transport","nanomaterials","stability","cold chain","controlled release","targeted delivery","biocompatibility"]; displayResults_recent(recent_papers); displayKeywordPapers(keywordsArray); // function stripslashes(str) { // if (typeof str === 'string') { // return str.replace(/\/g, ''); // } // } </script></p> <h3><b>Future Directions and Challenges</b></h3> <p><span style="font-weight: 400;">Even though the potential of COF-based nanomaterials seems brilliant for storage and transport of vaccines, there are numerous challenges. The process of synthesis and functionalization of the COFs needs to be optimized so that the final products show consistency and scale. Additionally, the biocompatibility and safety evaluation of materials based on COFs need to be addressed at the preclinical and clinical levels of study.</span></p> <p><span style="font-weight: 400;">In this respect, future research should be geared toward the preparation of COFs having more advanced functionalities, particularly those having multi-responsive properties that could adapt to these changes in environmental conditions. The concomitant hybridization with other types of nanomaterials, including metal-organic frameworks or polymers, might further improve the inherent performance of the COF-based system applied for vaccine storage and transport.</span></p> <p><span style="font-weight: 400;">Additionally, the regulatory landscape must be carefully navigated regarding the nano-biomedical use of these materials. A clear, generic set of standardized protocols for the evaluation and approval of materials based on COF is greatly needed if these materials are to be translated to the clinic.</span></p> <h3><b>Conclusion</b></h3> <p><span style="font-weight: 400;">Such COF-based nanomaterials serve as a game-changer in vaccine maintenance and transportation, combining very high stability, protection, and delivery effectiveness. With the unique features offered by COFs, researchers and developers can overcome a host of limitations faced by the traditional process of vaccine logistics so far. Further development in the given area might assist in finding a reliable and efficient way for vaccine distribution with COF-based systems and, therefore, make a contribution to global public health.</span></p> <p></p> <h3><b>References</b></h3> <ol> <li>Ding, J., Guan, X., Lv, J., Chen, X., Zhang, Y., Li, H., Zhang, D., Qiu, S., Jiang, H.L. and Fang, Q., 2023. <a href="https://pubs.acs.org/doi/abs/10.1021/jacs.2c13817">Three-dimensional covalent organic frameworks with ultra-large pores for highly efficient photocatalysis.</a> <i>Journal of the American Chemical Society</i>, <i>145</i>(5), pp.3248-3254.</li> <li>Jin, F., Lin, E., Wang, T., Geng, S., Hao, L., Zhu, Q., Wang, Z., Chen, Y., Cheng, P. and Zhang, Z., 2022. <a href="https://pubs.acs.org/doi/abs/10.1021/jacs.2c10548">Rationally fabricating three-dimensional covalent organic frameworks for propyne/propylene separation.</a> <i>Journal of the American Chemical Society</i>, <i>144</i>(50), pp.23081-23088.</li> <li>Xu, X., Cai, P., Chen, H., Zhou, H.C. and Huang, N., 2022. <a href="https://pubs.acs.org/doi/abs/10.1021/jacs.2c07733">Three-dimensional covalent organic frameworks with she topology.</a> <i>Journal of the American Chemical Society</i>, <i>144</i>(40), pp.18511-18517.</li> <li>Liu, W., Gong, L., Liu, Z., Jin, Y., Pan, H., Yang, X., Yu, B., Li, N., Qi, D., Wang, K. and Wang, H., 2022. <a href="https://pubs.acs.org/doi/abs/10.1021/jacs.2c07596">Conjugated three-dimensional high-connected covalent organic frameworks for lithium–sulfur batteries.</a> <i>Journal of the American Chemical Society</i>, <i>144</i>(37), pp.17209-17218.</li> <li>Gong, C., Wang, H., Sheng, G., Wang, X., Xu, X., Wang, J., Miao, X., Liu, Y., Zhang, Y., Dai, F. and Chen, L., 2022. <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202204899">Synthesis and Visualization of Entangled 3D Covalent Organic Frameworks with High‐Valency Stereoscopic Molecular Nodes for Gas Separation.</a> <i>Angewandte Chemie International Edition</i>, <i>61</i>(32), p.e202204899.</li> <li>Shan, Z., Wu, M., Zhu, D., Wu, X., Zhang, K., Verduzco, R. and Zhang, G., 2022. <a href="https://pubs.acs.org/doi/abs/10.1021/jacs.2c01037">3D covalent organic frameworks with interpenetrated pcb topology based on 8-connected cubic nodes.</a> <i>Journal of the American Chemical Society</i>, <i>144</i>(13), pp.5728-5733.</li> <li>Li, M., Yang, D., Biendicho, J.J., Han, X., Zhang, C., Liu, K., Diao, J., Li, J., Wang, J., Heggen, M. and Dunin‐Borkowski, R.E., 2022. <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202200529">Enhanced Polysulfide Conversion with Highly Conductive and Electrocatalytic Iodine‐Doped Bismuth Selenide Nanosheets in Lithium–Sulfur Batteries.</a> <i>Advanced functional materials</i>, <i>32</i>(26), p.2200529.</li> <li>Jin, F., Lin, E., Wang, T., Geng, S., Wang, T., Liu, W., Xiong, F., Wang, Z., Chen, Y., Cheng, P. and Zhang, Z., 2022. <a href="https://pubs.acs.org/doi/abs/10.1021/jacs.2c01058">Bottom-up synthesis of 8-connected three-dimensional covalent organic frameworks for highly efficient ethylene/ethane separation.</a> <i>Journal of the American Chemical Society</i>, <i>144</i>(12), pp.5643-5652.</li> </ol> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Top Experts on “<b style="color:#000;font-size:22px;">vaccine storage</b>“</h2> </div> </div><div class="author-main"><div id="results_author"></div><div style="text-align: center;"><a class="register-button" href="https://vaccine-studies.com/expert-search" target="_blank" rel="noopener">Find experts on any field</a></div></div><div class="inside-article" style="background: none;border: none;box-shadow: none;margin-top: -70px;"> <style> .author-block { padding: 15px; 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Thielmann", "citation_count": 207, "hindex": 8, "paper_count": 24, "affiliation": "Institute for General Practice, University of Duisburg-Essen, University Hospital Essen, Hufelandstra\u00dfe 55, 45147 Essen, Germany; Institute of General Practice and Family Medicine, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany. ", "email": "Anika.Thielmann@ukbonn.de", "slug_tail": "a-thielmann" }, "ItejK4wBWBy50K-r4IPw": { "aid": "ItejK4wBWBy50K-r4IPw", "name": "M. Gold", "citation_count": 262, "hindex": 7, "paper_count": 13, "affiliation": "Discipline of Paediatrics, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia. ", "email": "Michael.gold@adelaide.edu.au", "slug_tail": "m-gold" }, "KOBkK4wBWBy50K-ru9be": { "aid": "KOBkK4wBWBy50K-ru9be", "name": "S. Nandeshwar", "citation_count": 249, "hindex": 7, "paper_count": 20, "affiliation": "Atal Bihari Vajpayee Government Medical College, Vidisha, India. ", "email": "drsunilnandeshwar@gmail.com", "slug_tail": "s-nandeshwar" }, "E2qEK4wBWBy50K-rkzt4": { "aid": "E2qEK4wBWBy50K-rkzt4", "name": "Joanie Robertson", "citation_count": 467, "hindex": 7, "paper_count": 12, "affiliation": "PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA, USA. ", "email": "jrobertson@path.org", "slug_tail": "joanie-robertson" }, "QzE9K4wBWBy50K-raMEl": { "aid": "QzE9K4wBWBy50K-raMEl", "name": "K. Zhugunissov", "citation_count": 90, "hindex": 6, "paper_count": 17, "affiliation": "Laboratory of Technology for Microbial Cultivation, Gvardeiskiy, Kazakhstan. ", "email": "kuandyk_83@mail.ru", "slug_tail": "k-zhugunissov" }, "Rw-wK4wBWBy50K-r3HUQ": { "aid": "Rw-wK4wBWBy50K-r3HUQ", "name": "Oliyad Kebede", "citation_count": 91, "hindex": 6, "paper_count": 13, "affiliation": "School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia. ", "email": "oliyadkebede@gmail.com", "slug_tail": "oliyad-kebede" }, "UqyWK4wBWBy50K-rDjif": { "aid": "UqyWK4wBWBy50K-rDjif", "name": "Ngwegwe Bulula", "citation_count": 67, "hindex": 5, "paper_count": 11, "affiliation": "Ministry of Health, Community Development, Gender, Elderly and Children, Dar es Salaam, Tanzania; East African Community Regional Centre of Excellence for Vaccines, Immunization and Health Supply Chain Management (EAC-RCEVIHSCM), Kigali, Rwanda. ", "email": "ngwegb78@gmail.com", "slug_tail": "ngwegwe-bulula" }, "aabwKowBWBy50K-rbuqz": { "aid": "aabwKowBWBy50K-rbuqz", "name": "Diriba Feyisa", "citation_count": 69, "hindex": 5, "paper_count": 12, "affiliation": "Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Mizan -Tepi University, Mizan-Aman, Ethiopia. ", "email": "diremask@gmail.com", "slug_tail": "diriba-feyisa" }, "0P-uK4wBWBy50K-rS5GT": { "aid": "0P-uK4wBWBy50K-rS5GT", "name": "Carla E Lee", "citation_count": 74, "hindex": 5, "paper_count": 6, "affiliation": "Centers for Disease Control and Prevention, 1600 Clifton Rd, MS A-04, Atlanta, GA 30333, USA. ", "email": "CLee@cdc.gov", "slug_tail": "carla-e-lee" }, "UR86K4wBWBy50K-rK4LU": { "aid": "UR86K4wBWBy50K-rK4LU", "name": "K. Sch\u00f6nenberger", "citation_count": 145, "hindex": 5, "paper_count": 20, "affiliation": "EssentialTech Centre, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland; ", "email": "klaus.schonenberger@epfl.ch", "slug_tail": "k-schonenberger" }, "_1jCK4wBWBy50K-rerc3": { "aid": "_1jCK4wBWBy50K-rerc3", "name": "Andrew Miller", "citation_count": 13, "hindex": 3, "paper_count": 6, "affiliation": "Intellectual Ventures Global Good Fund, Bellevue, WA 98007 ", "email": "andymiller@gmail.com", "slug_tail": "andrew-miller" }, "e6XUK4wBWBy50K-rDkjR": { "aid": "e6XUK4wBWBy50K-rDkjR", "name": "Amani Thomas Mori", "citation_count": 14, "hindex": 2, "paper_count": 3, "affiliation": "Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania; Chr. Michelsen Institute P.O. Box 6033, Bergen, N-5892, Norway. ", "email": "pax_amani@yahoo.com", "slug_tail": "amani-thomas-mori" }, "my48K4wBWBy50K-r0Q4k": { "aid": "my48K4wBWBy50K-r0Q4k", "name": "Paul Wembridge", "citation_count": 5, "hindex": 1, "paper_count": 8, "affiliation": "Eastern Health, Australia; South West Healthcare, Ryot Street, Warrnambool, Victoria 3280, Australia. ", "email": "pwembridge@swh.net.au", "slug_tail": "paul-wembridge" } }; //console.log(authors_data); displayResults_author(authors_data); var keywordsArray = ["Covalent Organic Frameworks","COFs","vaccine storage","vaccine transport","nanomaterials","stability","cold chain","controlled release","targeted delivery","biocompatibility"]; displayKeywordAuthors(keywordsArray); </script></p> </div> <footer class="entry-meta" aria-label="Entry meta"> <span class="cat-links"><span class="gp-icon icon-categories"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M0 112c0-26.51 21.49-48 48-48h110.014a48 48 0 0143.592 27.907l12.349 26.791A16 16 0 00228.486 128H464c26.51 0 48 21.49 48 48v224c0 26.51-21.49 48-48 48H48c-26.51 0-48-21.49-48-48V112z" /></svg></span><span class="screen-reader-text">Categories </span><a href="https://vaccine-studies.com/archive/category/vaccine-storage/" rel="category tag">Vaccine Storage</a></span> <span 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