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antileishmanial activity</title> <meta name="description" content="Search results for: in vitro antileishmanial activity"> <meta name="keywords" content="in vitro antileishmanial activity"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="in vitro antileishmanial activity"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 7113</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: in vitro antileishmanial activity</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7113</span> Invitro Study of Anti-Leishmanial Property of Nigella Sativa Methanalic Black Seed Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tawqeer%20Ali%20Syed">Tawqeer Ali Syed</a>, <a href="https://publications.waset.org/abstracts/search?q=Prakash%20Chandra"> Prakash Chandra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study aims to evaluate the antileishmanial activity of Nigella sativa black seed extract. This well-known plant extract was taken from the botanical garden of Kashmir. Materials and Methods: The methanolic extracts of these plants were screened for their antileishmanial activity against Leishmania major using 3‑(4.5‑dimethylthiazol‑2yl)‑2.5‑diphenyltetrazolium bromide assay or MTT assay. Results: The methanolic extract of Nigella sativa showed potential antileishmanial activity at an inhibition% value of 80.29% ± 0.65%. IC 50 was calculated after 48 hours to be 964.3 µg/ml. Conclusion: Considering these results, these medicinal plants from Kashmir could serve as potential drug sources for antileishmanial compounds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MTT%20assay" title="MTT assay">MTT assay</a>, <a href="https://publications.waset.org/abstracts/search?q=antileishmanial" title=" antileishmanial"> antileishmanial</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20viability" title=" cell viability"> cell viability</a>, <a href="https://publications.waset.org/abstracts/search?q=Nigella%20sativa" title=" Nigella sativa"> Nigella sativa</a> </p> <a href="https://publications.waset.org/abstracts/138432/invitro-study-of-anti-leishmanial-property-of-nigella-sativa-methanalic-black-seed-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138432.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">212</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7112</span> Methanolic Extract of the Exudates of Aloe Otallensis and Its Effect on Leishmania Donovani Parasite</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zerihun%20Tesfaye%20Nigusse">Zerihun Tesfaye Nigusse</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: This study evaluates the antileishmanial activity of the methanolic extract of Aloe otallensis (A. otallensis) on the promastigote stage of Leishmaniadonovani (L. donovani) as compared to standard drugs and to screen its phytochemical constituents. Methods: Phytochemical screening was done by using the method mentioned by Evans and Trease on methanolic extract of the exudates of Aloe otallensis leaves. The extract was also evaluated for in vitro antileishmanial activity against L. donavani, which is found in the Parasitology Unit of Black Lion Hospital. The result was compared to standard drugs of sodium stibogluconate, milfostin and paramomycin. Results: The extract has good antileishmanial activity with an IC50 of 0.123 0 μg/mL on L. donovani (AM 563). The experimental data showed that relatively, it had better activity than paramomycin and milfostin but less activity than sodium stibogluconate. The data analyses were done by GraphPad Prism version 5 software after it was read by an ELISA reader at the wavelength of 650 nm. The phytochemical screening of the exudates of A. otallensis showed the presence of phenol, alkaloid and saponin. Conclusions: The methanol extract of the exudates of A.otallensishas a good anti- leishmaniasis activity and this may be attributed to phenol, alkaloid and saponin present in the plant. But it needs further analysis for the conformation of which constituent presents in high concentration to know which one has the strongest effect. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anti%20leshimaniasis" title="anti leshimaniasis">anti leshimaniasis</a>, <a href="https://publications.waset.org/abstracts/search?q=aloe%20otallensis" title=" aloe otallensis"> aloe otallensis</a>, <a href="https://publications.waset.org/abstracts/search?q=leshimania%20ethiopica" title=" leshimania ethiopica"> leshimania ethiopica</a>, <a href="https://publications.waset.org/abstracts/search?q=IC50" title=" IC50"> IC50</a> </p> <a href="https://publications.waset.org/abstracts/188744/methanolic-extract-of-the-exudates-of-aloe-otallensis-and-its-effect-on-leishmania-donovani-parasite" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188744.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">40</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7111</span> 4(3H)-Quinazolinone Derivatives' Synthesis and Evaluation as Antimalarial and Anti-Leishmanial Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alemu%20Tadesse%20Feroche">Alemu Tadesse Feroche</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, some 2, 3 distributed quinazoline -4 (3H) - one derivative were synthesized using a three-step synthetic route. They were obtained in a good yield (59.5-85%) by applying different chemical reactions like cyclization and condensation reactions. The chemical structure of the final compounds was also verified by spectroscopic methods (IR, ¹HNMR) and elemental microanalysis. The in vivo antimalarial activity of these compounds on P. berghei infected mice was found to be moderate to high at an oral dose of 0.04846 mmol/kg /day. This is equal to 25 mg/kg of chloroquine phosphate, which causes 100% inhibition of the parasite. It is worth mentioning that most active compounds (E) -3 Phenyl -2- [2- (pyridine -4- yl) vinyl] -4 (3H) -quinazolinone IVa (64.02%, (E)-2-[2-(4 - Hydroxy-3 - methoxystyryl) - vinyl) -3 - phenyl -4 (3H ) - quinazolinone IVc (77.25%) and (E)-2 –[2 –(Pyridin -4-yl) –vinyl] -3 phenenylamine -4(3H) quinazolinone IVe (73.54%) showed a dose-dependent increase in present suppression in antimalarial activities. Furthermore, the synthesized compounds were screened for their in vitro antileishmanial activity against L. aethiopica isolate (CL/039/09). All tested compounds (IVa (0.03766 ug/ml), IVb (0.00538 ug/ml, IVc (0.00412 ug/ml, IVd (0.00110 ug/ml), IVe (0.03017 ug/ml) and IVf (0.03894 ug/ml)) showed excellent potency that is much better than amphotericin B (IC50 = 0,04359 ug/ml). The results of acute toxicity indicated that all test compounds (IVa –IVf) proved to be nontoxic and well tolerated by the experimental animals up to 300 mg/kg in oral and 140 mg/kg in parental studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=4%283H%29-quinazolinone" title="4(3H)-quinazolinone">4(3H)-quinazolinone</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vivo%20antimalarial%20activity" title=" in vivo antimalarial activity"> in vivo antimalarial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20antileishmanial%20activity" title=" in vitro antileishmanial activity"> in vitro antileishmanial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title=" acute toxicity"> acute toxicity</a> </p> <a href="https://publications.waset.org/abstracts/153719/43h-quinazolinone-derivatives-synthesis-and-evaluation-as-antimalarial-and-anti-leishmanial-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153719.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7110</span> Pyrazolylpyrazolines: Design, Synthesis and Biological Evaluation as Dual Acting Antimalarial-Antileishmanial Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adnan%20Bekhit">Adnan Bekhit</a>, <a href="https://publications.waset.org/abstracts/search?q=Eskedar%20Lodebo"> Eskedar Lodebo</a>, <a href="https://publications.waset.org/abstracts/search?q=Ariaya%20Hymete"> Ariaya Hymete</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanan%20Ragab"> Hanan Ragab</a>, <a href="https://publications.waset.org/abstracts/search?q=Alaa%20El-Din%20Bekhit"> Alaa El-Din Bekhit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Malaria and leishmaniasis have emerged as serious universal health problems throughout history of mankind. According to the WHO 2008 malarial report, half of the world population is at risk of malarial infection with an estimate of 1 million deaths occurring annually mainly in the African region. Furthermore, 12-15 million people are infected with Leishmaniasis worldwide. Despite the continuous introduction of a large number of agents for the treatment of malaria, there is still unmet medical needs due to the emergence of resistance. Resistance has occurred for almost all therapeutic agents approved for the treatment of malaria. Accordingly, it was the aim of this work to design and synthesis a group of antimalarial-antileshmanial agents that would show inhibitory activity against chloroquine-resistant strain of Plasmodium falciparum. The synthesized compounds were designed to contain a pyrazolylpyrazoline moiety having an aromatic group (p-tolyl or p-chlorophenyl) at N1-position of one pyrazoline ring due to the reports of promising activities of such compounds. A formyl or acyl substituent was introduced at the N1-position of the other pyrazoline ring, to investigate the effect of bulkiness of acyl substituents at this position. The synthesized compounds were evaluated for their in-vivo antimalarial activity against Plasmodium berghei infected mice at dose levels of 20 and 30 mg/Kg. the two most active compounds were evaluated for their antimalarial activity against chloroquin-resistant strain (RKL9) of Plasmodium falciparum. In addition, the synthesized compounds were tested for their in-vitro antileshmanial activity against Leishmania aethiopica promastigotes and amastigotes. For both antimalarial and antileishmanial activities, compounds having an N1-p-tolyl group at the first pyrazoline ring did not require bulkiness at the second pyrazoline ring nitrogen where the compound bearing an acetyl group proved to be the most active of the whole series. On the other hand, bulkiness at the N1-position of the second pyazoline ring was necessary in case of compounds carrying the p-chlorophenyl group, where the two derivatives having an N1-butanoyl and an N1-benzoyl moieties at the second pyrazoline showed the best activity. Furthermore, the toxicity of the active compounds were tested and were proved to be non-toxic at 125, 250 and 500 mg/Kg. In addition, docking of the most active compound (having a p-tolyl group at the first pyrazoline-N and an acetyl moiety on the other pyrazoline-N) was performed against dihydrofolate reductase enzyme. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pyrazoline%20derivatives" title="pyrazoline derivatives">pyrazoline derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=in-vivo%20antimalarial%20activity" title=" in-vivo antimalarial activity"> in-vivo antimalarial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a>, <a href="https://publications.waset.org/abstracts/search?q=dihydrofolate%20reductase" title=" dihydrofolate reductase"> dihydrofolate reductase</a> </p> <a href="https://publications.waset.org/abstracts/62770/pyrazolylpyrazolines-design-synthesis-and-biological-evaluation-as-dual-acting-antimalarial-antileishmanial-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62770.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">341</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7109</span> In-vitro Antioxidant Activity of Two Selected Herbal Medicines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Vinotha">S. Vinotha</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Thabrew"> I. Thabrew</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Sri%20Ranjani"> S. Sri Ranjani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hot aqueous and methanol extracts of the two selected herbal medicines such are Vellarugu Chooranam (V.C) and Amukkirai Chooranam (A.C) were examined for total phenolic and flavonoid contents and in-vitro antioxidant activity using four different methods. The total phenolic and flavonoid contents in methanol extract of V.C were found to be higher (44.41±1.26 mg GAE⁄g; 174.44±9.32 mg QE⁄g) than in the methanol extract of A.C (20.56±0.67 mg GAE⁄g;7.21±0.85 mg QE⁄g). Hot methanol and aqueous extracts of both medicines showed low antioxidant activity in DPPH, ABTS, and FRAP methods and Iron chelating activity not found at highest possible concentration. V.C contains higher concentrations of total phenolic and flavonoid contents than A.C and can also exert greater antioxidant activity than A.C, although the activities demonstrated were lower than the positive control Trolox. The in-vitro antioxidant activity was not related with the total phenolic and flavonoid contents of the methanol and aqueous extracts of both herbal medicines (A.C and V.C). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=activity" title="activity">activity</a>, <a href="https://publications.waset.org/abstracts/search?q=different%20extracts" title=" different extracts"> different extracts</a>, <a href="https://publications.waset.org/abstracts/search?q=herbal%20medicines" title=" herbal medicines"> herbal medicines</a>, <a href="https://publications.waset.org/abstracts/search?q=in-vitro%20antioxidant" title=" in-vitro antioxidant"> in-vitro antioxidant</a> </p> <a href="https://publications.waset.org/abstracts/16823/in-vitro-antioxidant-activity-of-two-selected-herbal-medicines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16823.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">405</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7108</span> Design, Synthesis and in-vitro Antitumor Evaluation of Some Novel Substituted Quinazoline Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adel%20S.%20El-Azab">Adel S. El-Azab</a>, <a href="https://publications.waset.org/abstracts/search?q=Alaa%20A.%20M.%20Abdel-Aziz"> Alaa A. M. Abdel-Aziz</a>, <a href="https://publications.waset.org/abstracts/search?q=Ibrahim%20A.%20Al-Suwaidan"> Ibrahim A. Al-Suwaidan</a>, <a href="https://publications.waset.org/abstracts/search?q=Amer%20M.%20Alanazi"> Amer M. Alanazi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A novel series of 2,3,6-trisubstitute quinazolinone were designed, synthesized, and evaluated for their in-vitro antitumor activity. 3 (Benzylideneamino)-6-chloro-2-p-tolylquinazolin-4(3H)-One, 2-[(4-oxo-3-phenethyl-3,4-dihydroquinazolin-2-yl)thio]-N-(3,4;5-trimethoxyphenyl) acetamide and 3-(3-benzyl-6-methyl-4-oxo-3, 4-dihydroquinazolin-2-ylthio)-N-(3,4,5-trimethoxyphenyl) propanamide have shown amazing broad spectrum antitumor activity with mean GI50; 15.8, 3.16, and 7.4 μM respectively compared to known Quinazoline Derivatives antitumor drug 5-FU mean GI50=22.6 μM. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=quinazoline%20derivatives" title="quinazoline derivatives">quinazoline derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20antitumor" title=" in vitro antitumor"> in vitro antitumor</a>, <a href="https://publications.waset.org/abstracts/search?q=synthesis" title=" synthesis"> synthesis</a>, <a href="https://publications.waset.org/abstracts/search?q=5-FU" title=" 5-FU"> 5-FU</a>, <a href="https://publications.waset.org/abstracts/search?q=NCI" title=" NCI"> NCI</a> </p> <a href="https://publications.waset.org/abstracts/22501/design-synthesis-and-in-vitro-antitumor-evaluation-of-some-novel-substituted-quinazoline-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22501.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">544</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7107</span> A Comparative Evaluation of Antioxidant Activity of in vivo and in vitro Raised Holarrhena antidysenterica Linn.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gayatri%20Nahak">Gayatri Nahak</a>, <a href="https://publications.waset.org/abstracts/search?q=Satyajit%20Kanungo"> Satyajit Kanungo</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajani%20Kanta%20Sahu"> Rajani Kanta Sahu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Holarrhena antidysenterica Linn. (Apocynaceae) is a typical Indian medicinal plant popularly known as “Indrajav”. Traditionally the plant has been considered a popular remedy for the treatment of dysentery, diarrhea, intestinal worms and the seeds of this plant are also used as an anti-diabetic remedy. In the present study axillary shoot multiplication, callus induction and shoot regeneration from callus culture were obtained on Murashige and Skoog (MS) medium supplemented with different concentrations and combinations of plant growth regulators. Then in vivo and in vitro grown healthy plants were selected for study of antioxidant activity through DPPH and OH methods. Significantly higher antioxidant activity and phenol contents were observed in vitro raised plant in comparison to in vivo plants. The findings indicated the greater amount of phenolic compounds leads to more potent radical scavenging effect as shown in in vitro raised plant in comparison to in vivo plants which showed the ability to utilize tissue culture techniques towards development of desired bioactive metabolites from in vitro culture as an alternative way to avoid using endangered plants in pharmaceutical purposes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Holarrhena%20antidysenterica" title="Holarrhena antidysenterica">Holarrhena antidysenterica</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro" title=" in vitro"> in vitro</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vivo" title=" in vivo"> in vivo</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a> </p> <a href="https://publications.waset.org/abstracts/16353/a-comparative-evaluation-of-antioxidant-activity-of-in-vivo-and-in-vitro-raised-holarrhena-antidysenterica-linn" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16353.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">510</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7106</span> In Vitro Antifungal Activity of Essential Oil Artemisia Absinthium</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bouchenak%20Fatima">Bouchenak Fatima</a>, <a href="https://publications.waset.org/abstracts/search?q=Lmegharbi%20Abdelbaki"> Lmegharbi Abdelbaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Houssem%20Degaichia"> Houssem Degaichia</a>, <a href="https://publications.waset.org/abstracts/search?q=Benrebiha%20Fatima"> Benrebiha Fatima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The essential oil composition of the leaf of Artemisia absinthium from region of Cherchell (The south of Algeria) was investigated by GC, GC-MS. 27 constituents were identified correspond to 84, 63% of the total oil. The major components are Thujone (60, 82%), Chamazulènel (16, 62%), ρ-cymène (4, 29%) and 2-carène (4.25%). The antimicrobial activity of oil was tested in vitro by two methods (agar diffusion and microdilution) on three plant pathogenic fungi. This oil has been tested for antimicrobial activity against three pathogenic fungi (Botrytis cinerea, Fusarium culmorum and Helminthosporium Sp.).The study of activity was evaluated by two methods: Method of diffusion in gelose and the minimum inhibitory concentration MIC. This oil exhibited an interesting antimicrobial activity. A preliminary study showed that this oil presented high toxicity against this fungus. These results, although preliminary show a good antifungal activity, to limit and inhibit stop the development of those pathogen agent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=artemisia%20absinthian" title="artemisia absinthian">artemisia absinthian</a>, <a href="https://publications.waset.org/abstracts/search?q=extraction%20process" title=" extraction process"> extraction process</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20study" title=" chemical study"> chemical study</a>, <a href="https://publications.waset.org/abstracts/search?q=antifungal%20activity" title=" antifungal activity"> antifungal activity</a> </p> <a href="https://publications.waset.org/abstracts/23681/in-vitro-antifungal-activity-of-essential-oil-artemisia-absinthium" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23681.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">484</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7105</span> Comparative Study of Antioxidant Activity in in vivo and in vitro Samples of Purple Greater Yam (Dioscorea alata L).</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sakinah%20Abdullah">Sakinah Abdullah</a>, <a href="https://publications.waset.org/abstracts/search?q=Rosna%20Mat%20Taha"> Rosna Mat Taha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Antioxidants are compounds that protect cells against the damaging effects of reactive oxygen species such as singlet oxygen, superoxide, peroxyl radicals, and peroxynitrite which result in oxidative stress leading to cellular damage. Natural antioxidant are in high demand because of their potential in health promotion and disease prevention and their improved safety and consumer acceptability. Plants are rich sources of natural antioxidant. Dioscorea alata L. known as 'ubi badak' in Malaysia were well known for their antioxidant content, but this plant was seasonal. Thus, tissue culture technique was used to mass propagate this plant. In the present work, a comparative study between in vitro (from tissue culture) and in vivo (from intact plant) samples of Dioscorea alata L. for their antioxidant potential by 2,2-diphenil -1- picrylhydrazyl (DPPH) radical scavenging activity method and their total phenolic and flavonoid contents were carried out. All samples had better radical scavenging activity but in vivo samples had the strongest radical scavenging activity compared to in vitro samples. Furthermore, tubers from in vivo samples showed the greatest free radical scavenging effect and comparatively greater phenolic content than in vitro samples. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dioscorea%20alata" title="Dioscorea alata">Dioscorea alata</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20culture" title=" tissue culture"> tissue culture</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vivo" title=" in vivo"> in vivo</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro" title=" in vitro"> in vitro</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPH" title=" DPPH"> DPPH</a> </p> <a href="https://publications.waset.org/abstracts/31969/comparative-study-of-antioxidant-activity-in-in-vivo-and-in-vitro-samples-of-purple-greater-yam-dioscorea-alata-l" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31969.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">469</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7104</span> Anti-Allergic Activities of Smilax Glabra Rhizome Extracts and Its Isolated Compounds</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arunporn%20Itharat">Arunporn Itharat</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamonmas%20Srikwan"> Kamonmas Srikwan</a>, <a href="https://publications.waset.org/abstracts/search?q=Srisopa%20Ruangnoo"> Srisopa Ruangnoo</a>, <a href="https://publications.waset.org/abstracts/search?q=Pakakrong%20Thongdeeying"> Pakakrong Thongdeeying</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: The rhizomes of Smilax glabra (SG) has long been used in Traditional Chinese and Thai herbal medicine to treat a variety of infectious diseases and immunological disorders. Objective: To investigate the in vitro anti-allergic activities of crude extracts and pure isolated flavonoid compounds from SG by determination of inhibitory effects on antigen-induced release of β-hexosaminidase from RBL-2H3 cells. Methods: The in vitro inhibitory effects of crude aqueous and organic extracts on beta-hexosaminidase release in RBL-2H3 cells were evaluated as an in vitro indication of possible anti-allergic activity in vivo. Bioassay-guided fractionation of extracts was used to isolate flavonoid compounds from the ethanolic extracts. Results: The 95% and 50% ethanolic extracts of SG showed remarkably high anti-allergic activity, with IC50 values of 5.74 ± 2.44 and 23.54 ± 4.75 μg/ml, much higher activity than that for Ketotifen (IC50 58.90 μM). The water extract had negligible activity (IC50 > 100 μg/ml). The two isolated flavonols, Engeletin and Astilbin, showed weak anti-allergic activity, IC50 values 97.46 ± 2.04 and > 100 μg/ml, respectively. Conclusions: The 95% and 50% ethanolic extracts of SG showed strong anti-allergic activity but two flavonol constituents did not show any significant anti-allergic activity. These findings suggest that a combination of effects of various phytochemicals in crude extracts used in traditional medicine are responsible for the purported anti-allergic activity of SG herbal preparations. The plethora of constituents in crude extracts, as yet unidentified, are likely to be acting synergistically to account for the strong observed anti-allergic in vitro activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Smilax%20glabra" title="Smilax glabra">Smilax glabra</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-allergic%20%20activity" title=" anti-allergic activity"> anti-allergic activity</a>, <a href="https://publications.waset.org/abstracts/search?q=RBL-2H3%20cells" title=" RBL-2H3 cells"> RBL-2H3 cells</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoid%20compounds" title=" flavonoid compounds"> flavonoid compounds</a> </p> <a href="https://publications.waset.org/abstracts/25044/anti-allergic-activities-of-smilax-glabra-rhizome-extracts-and-its-isolated-compounds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25044.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">667</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7103</span> Synthesis, Biological Evaluation and Molecular Modeling Studies on Chiral Chloroquine Analogues as Antimalarial Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Srinivasarao%20Kondaparla">Srinivasarao Kondaparla</a>, <a href="https://publications.waset.org/abstracts/search?q=Utsab%20Debnath"> Utsab Debnath</a>, <a href="https://publications.waset.org/abstracts/search?q=Awakash%20Soni"> Awakash Soni</a>, <a href="https://publications.waset.org/abstracts/search?q=Vasantha%20%20Rao%20Dola"> Vasantha Rao Dola</a>, <a href="https://publications.waset.org/abstracts/search?q=Manish%20Sinha"> Manish Sinha</a>, <a href="https://publications.waset.org/abstracts/search?q=Kumkum%20Kumkum%20Srivastava"> Kumkum Kumkum Srivastava</a>, <a href="https://publications.waset.org/abstracts/search?q=Sunil%20K.%20%20Puri"> Sunil K. Puri</a>, <a href="https://publications.waset.org/abstracts/search?q=Seturam%20B.%20Katti"> Seturam B. Katti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In a focused exploration, we have designed synthesized and biologically evaluated chiral conjugated new chloroquine (CQ) analogs with substituted piperazines as antimalarial agents. In vitro as well as in vivo studies revealed that compound 7c showed potent activity [for in vitro IC₅₀= 56.98nM (3D7), 97.76nM (K1); for in vivo (up to at the dose of 12.5 mg/kg); SI = 3510] as a new lead of antimalarial agent. Other compounds 6b, 6d, 7d, 7h, 8c, 8d, 9a, and 9c are also showing moderate activity against CQ-sensitive (3D7) strain and superior activity against resistant (K1) strain of P. falciparum. Furthermore, we have carried out docking and 3D-QSAR studies of all in-house data sets (168 molecules) of chiral CQ analogs to explain the structure activity relationships (SAR). Our new findings specified the significance of H-bond interaction with the side chain of heme for biological activity. In addition, the 3D-QSAR study against 3D7 strain indicated the favorable and unfavorable sites of CQ analogs for incorporating steric, hydrophobic and electropositive groups to improve the antimalarial activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=piperazines" title="piperazines">piperazines</a>, <a href="https://publications.waset.org/abstracts/search?q=CQ-sensitive%20strain-3D7" title=" CQ-sensitive strain-3D7"> CQ-sensitive strain-3D7</a>, <a href="https://publications.waset.org/abstracts/search?q=in-vitro%20and%20in-vivo%20assay" title=" in-vitro and in-vivo assay"> in-vitro and in-vivo assay</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a>, <a href="https://publications.waset.org/abstracts/search?q=3D-QSAR" title=" 3D-QSAR"> 3D-QSAR</a> </p> <a href="https://publications.waset.org/abstracts/95175/synthesis-biological-evaluation-and-molecular-modeling-studies-on-chiral-chloroquine-analogues-as-antimalarial-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/95175.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">171</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7102</span> An in vitro Study on Synergetic Antifungal Activity of Garlic Extract with Honey and Lemon Juice against Candida sp.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20Karpagam">P. Karpagam</a>, <a href="https://publications.waset.org/abstracts/search?q=Babu%20Joseph"> Babu Joseph</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Ashok%20Kumar"> P. Ashok Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The incidence of Candida infections is increasing worldwide. The serious nature of these infections is compounded by increasing levels of drug resistance. Pure cultures of the Candida sp. were obtained from clinical isolates and fresh garlic extracts were obtained by extraction techniques. The antifungal activity of garlic extract was investigated in an in vitro system. The extract (100%, 75% and 50%) showed significant antifungal activity against Candida, whereas, low concentration (25%) of the extract showed less antifungal activity against the test organism. Antifungal activities of honey and lemon juice were tested against the Candida; however, the growth was not inhibited by these extracts. On the other hand honey and lemon when combined with garlic exhibited a good antifungal activity. The study thus confirms the antifungal properties of garlic extract along with additives like honey and lemon have significant antifungal activity against isolates of Candida species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Candida" title="Candida">Candida</a>, <a href="https://publications.waset.org/abstracts/search?q=garlic%20extract" title=" garlic extract"> garlic extract</a>, <a href="https://publications.waset.org/abstracts/search?q=lemon" title=" lemon"> lemon</a>, <a href="https://publications.waset.org/abstracts/search?q=synergitic%20antifungal%20activity" title=" synergitic antifungal activity"> synergitic antifungal activity</a> </p> <a href="https://publications.waset.org/abstracts/75056/an-in-vitro-study-on-synergetic-antifungal-activity-of-garlic-extract-with-honey-and-lemon-juice-against-candida-sp" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75056.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">250</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7101</span> Synthesis, Characterization and in vitro DNA Binding and Cleavage Studies of Cu(II)/Zn(II) Dipeptide Complexes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Jamsheera">A. Jamsheera</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Arjmand"> F. Arjmand</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20K.%20Mohapatra"> D. K. Mohapatra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Small molecules binding to specific sites along DNA molecule are considered as potential chemotherapeutic agents. Their role as mediators of key biological functions and their unique intrinsic properties make them particularly attractive therapeutic agents. Keeping in view, novel dipeptide complexes Cu(II)-Val-Pro (1), Zn(II)-Val-Pro (2), Cu(II)-Ala-Pro (3) and Zn(II)-Ala-Pro (4) were synthesized and thoroughly characterized using different spectroscopic techniques including elemental analyses, IR, NMR, ESI–MS and molar conductance measurements. The solution stability study carried out by UV–vis absorption titration over a broad range of pH proved the stability of the complexes in solution. In vitro DNA binding studies of complexes 1–4 carried out employing absorption, fluorescence, circular dichroism and viscometric studies revealed the binding of complexes to DNA via groove binding. UV–vis titrations of 1–4 with mononucleotides of interest viz., 5´-GMP and 5´-TMP were also carried out. The DNA cleavage activity of the complexes 1 and 2 were ascertained by gel electrophoresis assay which revealed that the complexes are good DNA cleavage agents and the cleavage mechanism involved a hydrolytic pathway. Furthermore, in vitro antitumor activity of complex 1 was screened against human cancer cell lines of different histological origin. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dipeptide%20Cu%28II%29%20and%20Zn%28II%29%20complexes" title="dipeptide Cu(II) and Zn(II) complexes">dipeptide Cu(II) and Zn(II) complexes</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20binding%20profile" title=" DNA binding profile"> DNA binding profile</a>, <a href="https://publications.waset.org/abstracts/search?q=pBR322%20DNA%20cleavage" title=" pBR322 DNA cleavage"> pBR322 DNA cleavage</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20anticancer%20activity" title=" in vitro anticancer activity"> in vitro anticancer activity</a> </p> <a href="https://publications.waset.org/abstracts/38418/synthesis-characterization-and-in-vitro-dna-binding-and-cleavage-studies-of-cuiiznii-dipeptide-complexes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38418.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">349</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7100</span> A Novel Peptide Showing Universal Effect against Multiple Viruses in Vitro and in Vivo</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hanjun%20Zhao">Hanjun Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Ke%20Zhang"> Ke Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Bojian%20Zheng"> Bojian Zheng </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: So far, there is no universal antiviral agent which can inhibit multiple viral infections. More and more drug-resistant viral strains emerge after the antiviral drug application for treatment. Defensins are the front line of host innate immunity and have broad spectrum antibacterial and antiviral effects. However, there is limited data to show if these defensins have good antiviral activity in vivo and what the antiviral mechanism is. Subjects: To investigate a peptide with widespread antivirus activity in vitro and in vivo and illustrate the antiviral mechanism. Methods: Antiviral peptide library designed from mouse beta defensins was synthesized by the company. Recombinant beta defensin was obtained from E. coli. Antiviral activity in vitro was assayed by plaque assay, qPCR. Antiviral activity in vivo was detected by animal challenge with 2009 pandemic H1N1 influenza A virus. The antiviral mechanism was assayed by western blot, ELISA, and qPCR. Conclusions: We identify a new peptide which has widespread effects against multiple viruses (H1N1, H5N1, H7N9, MERS-CoV) in vitro and has efficient antivirus activity in vivo. This peptide inhibits viral entry into target cells and subsequently blocks viral replication. The in vivo study of the antiviral peptide against other viral infections and the investigation of its more detail antiviral mechanism are ongoing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20peptide" title="antiviral peptide">antiviral peptide</a>, <a href="https://publications.waset.org/abstracts/search?q=defensin" title=" defensin"> defensin</a>, <a href="https://publications.waset.org/abstracts/search?q=Influenza%20A%20virus" title=" Influenza A virus"> Influenza A virus</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanism" title=" mechanism"> mechanism</a> </p> <a href="https://publications.waset.org/abstracts/29172/a-novel-peptide-showing-universal-effect-against-multiple-viruses-in-vitro-and-in-vivo" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29172.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">400</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7099</span> In vitro Effects of Amygdalin on the Functional Competence of Rabbit Spermatozoa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marek%20Halen%C3%A1r">Marek Halenár</a>, <a href="https://publications.waset.org/abstracts/search?q=Eva%20Tvrd%C3%A1"> Eva Tvrdá</a>, <a href="https://publications.waset.org/abstracts/search?q=Tom%C3%A1%C5%A1%20Slanina"> Tomáš Slanina</a>, <a href="https://publications.waset.org/abstracts/search?q=%C4%BDubom%C3%ADr%20Ondru%C5%A1ka"> Ľubomír Ondruška</a>, <a href="https://publications.waset.org/abstracts/search?q=Eduard%20Koles%C3%A1r"> Eduard Kolesár</a>, <a href="https://publications.waset.org/abstracts/search?q=Peter%20Mass%C3%A1nyi"> Peter Massányi</a>, <a href="https://publications.waset.org/abstracts/search?q=Adriana%20Koles%C3%A1rov%C3%A1"> Adriana Kolesárová </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present <em>in vitro</em> study was designed to reveal whether amygdalin (AMG) is able to cause changes to the motility, viability and mitochondrial activity of rabbit spermatozoa. New Zealand White rabbits (n = 10) aged four months were used in the study. Semen samples were collected from each animal and used for the <em>in vitro </em>incubation. The samples were divided into five equal parts and diluted with saline supplemented with 0, 0.5, 1, 2.5 and 5 mg/mL AMG. At times 0h, 3h and 5h spermatozoa motion parameters were assessed using the SpermVision™ computer-aided sperm analysis (CASA) system, cell viability was examined with the metabolic activity (MTT) assay, and the eosin-nigrosin staining technique was used to evaluate the viability of rabbit spermatozoa. All AMG concentrations exhibited stimulating effects on the spermatozoa activity, as shown by a significant preservation of the motility (P<0.05 with respect to 0.5 mg/mL and 1 mg/mL AMG; Time 5 h) and mitochondrial activity (P< 0.05 in case of 0.5 mg/mL AMG; P< 0.01 in case of 1 mg/mL AMG; P < 0.001 with respect to 2.5 mg/mL and 5 mg/mL AMG; Time 5 h). None of the AMG doses supplemented had any significant impact of the spermatozoa viability. In conclusion, the data revealed that short-term co-incubation of spermatozoa with AMG may result in a higher preservation of the sperm structural integrity and functional activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amygdalin" title="amygdalin">amygdalin</a>, <a href="https://publications.waset.org/abstracts/search?q=CASA" title=" CASA"> CASA</a>, <a href="https://publications.waset.org/abstracts/search?q=mitochondrial%20activity" title=" mitochondrial activity"> mitochondrial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=motility" title=" motility"> motility</a>, <a href="https://publications.waset.org/abstracts/search?q=rabbits" title=" rabbits"> rabbits</a>, <a href="https://publications.waset.org/abstracts/search?q=spermatozoa" title=" spermatozoa"> spermatozoa</a>, <a href="https://publications.waset.org/abstracts/search?q=viability" title=" viability"> viability</a> </p> <a href="https://publications.waset.org/abstracts/55018/in-vitro-effects-of-amygdalin-on-the-functional-competence-of-rabbit-spermatozoa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55018.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">330</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7098</span> Quinazolino-Thiazoles: Fused Pharmacophores as Antimicrobial Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Bari">Sanjay Bari</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinod%20Ugale"> Vinod Ugale</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamalkishor%20Patil"> Kamalkishor Patil</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Over the past several years the emergence of micro-organisms resistant to nearly all the class of antimicrobial agents has become a serious public health concern. In the present research, we report the synthesis and in-vitro antimicrobial activity of a new series of novel quinazolino-thiadiazoles 3 (a-j). The synthesized compounds were confirmed by melting point, IR, 1H-NMR, 13C NMR and Mass spectroscopy. In general, the results of the in-vitro antibacterial activity are encouraging, as out of 10 compounds tested, Compound 3f and 3i with a 4-chloro phenyl and 4-nitro phenyl at C-2 of thiadiazolyl of quinazolino-thiadiazoles, displayed the excellent antibacterial and antifungal activities against all the tested microorganisms (Bacterial and Fungal strain) with MIC values of 62.5 μg/mL. It is worth to mention that the combination of two biologically active moieties quinazoline and thiadiazole profoundly influences the biological activity. While evaluating the antimicrobial activity, it was observed that compounds having electron withdrawing groups on thiazole has shown profound activity in comparison to compounds having electron releasing groups. As a result of this study, it can be concluded that halogen substituent on thiazole ring increases antimicrobial activity. Possible improvements in the antimicrobial activity can be further achieved by slight modifications in the substituent’s and/or additional structural activity investigations to have good antimicrobial activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antifungal" title="antifungal">antifungal</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title=" antimicrobial"> antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=quinazolino-thiazoles" title=" quinazolino-thiazoles"> quinazolino-thiazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=synthesis" title=" synthesis "> synthesis </a> </p> <a href="https://publications.waset.org/abstracts/20080/quinazolino-thiazoles-fused-pharmacophores-as-antimicrobial-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20080.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">415</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7097</span> Identification of Synthetic Hybrids of 4-Thiazolidinone-Bromopyrrole Alkaloid as HIV-1 RT Inhibitors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rajesh%20A.%20Rane">Rajesh A. Rane</a>, <a href="https://publications.waset.org/abstracts/search?q=Shital%20S.%20Naphade"> Shital S. Naphade</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajshekhar%20Karpoormath"> Rajshekhar Karpoormath</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Thiozolidin-4-one, a mimic of thiazolobenzimidazole (TBZ) has drawn many attentions due to its potent and selective inhibition against the HIV-1 and low toxicity by binding to the allosteric site of the reverse transcriptase (RT) as a non-nucleoside RT inhibitor (NNRTI). Similarly, marine bromopyrrole alkaloids are well known for their diverse array of anti-infective properties. Hence, we have reported synthesis and in vitro HIV-1 RT inhibitory activity of a series of 4-thiazolidinone-bromopyrrole alkaloid hybrids tethered with amide linker. The results of in vitro HIV-1 RT kit assay showed that some of the compounds, such as 4c, 4d, and 4i could effectively inhibit RT activity. Among them, compounds 4c having 4-chlorophenyl substituted 4-thiazolidione ring was the best one with the IC50 value of 0.26 µM. The sturdy emerges with key structure-activity relationship that pyrrole-NH-free core benefited inhibition against HIV-1 RT inhibition. This study identified conjugate 4c with potent activity and selectivity as promising compound for further drug development to HIV. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20drugs" title="antiviral drugs">antiviral drugs</a>, <a href="https://publications.waset.org/abstracts/search?q=bromopyrrole%20alkaloids" title=" bromopyrrole alkaloids"> bromopyrrole alkaloids</a>, <a href="https://publications.waset.org/abstracts/search?q=HIV-1%20RT%20inhibition" title=" HIV-1 RT inhibition"> HIV-1 RT inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=4-thiazolidinone" title=" 4-thiazolidinone"> 4-thiazolidinone</a> </p> <a href="https://publications.waset.org/abstracts/35304/identification-of-synthetic-hybrids-of-4-thiazolidinone-bromopyrrole-alkaloid-as-hiv-1-rt-inhibitors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35304.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">459</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7096</span> Synthesis, Molecular Docking, and Cytotoxic Activity of Novel Triazolopyridazine Derivatives </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Azza%20T.%20Tahera">Azza T. Tahera</a>, <a href="https://publications.waset.org/abstracts/search?q=Eman%20M.%20Ahmeda"> Eman M. Ahmeda</a>, <a href="https://publications.waset.org/abstracts/search?q=Nadia%20A.%20Khalila"> Nadia A. Khalila</a>, <a href="https://publications.waset.org/abstracts/search?q=Yassin%20M.%20Nissanb"> Yassin M. Nissanb</a> </p> <p class="card-text"><strong>Abstract:</strong></p> New 3-(pyridin-4-yl)-[1,2,4] triazolo [4,3-b] pyridazine derivatives 2a-i, 4a,b and 6a,b were designed, synthesized and evaluated as cytotoxic agents. All compounds were investigated for their in vitro cytotoxicity at a single dose 10-5M concentration towards 60 cancer cell lines according to USA NCI protocol. The preliminary screening results showed that the majority of tested compounds exhibited remarkable activity against SR (leukemia) cell panel. Molecular docking for all synthesized compounds was performed on the active site of c-Met kinase. The most active compounds, 2f and 4a were further evaluated at a seven dose level screening and their IC50 as a c-Met kinase inhibitors were determined in vitro. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=triazolopyridazines" title="triazolopyridazines">triazolopyridazines</a>, <a href="https://publications.waset.org/abstracts/search?q=pyridazines" title=" pyridazines"> pyridazines</a>, <a href="https://publications.waset.org/abstracts/search?q=cytotoxic%20activity" title=" cytotoxic activity"> cytotoxic activity</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20panel" title=" cell panel"> cell panel</a> </p> <a href="https://publications.waset.org/abstracts/22560/synthesis-molecular-docking-and-cytotoxic-activity-of-novel-triazolopyridazine-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22560.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">536</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7095</span> Study of the in vivo and in vitro Antioxidant Activity of the Methanol Extract from the Roots of the Barks of Zizyphus lotus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Djemai%20Zoughlache%20Soumia">Djemai Zoughlache Soumia</a>, <a href="https://publications.waset.org/abstracts/search?q=Yahia%20Mouloud"> Yahia Mouloud</a>, <a href="https://publications.waset.org/abstracts/search?q=Lekbir%20Adel"> Lekbir Adel</a>, <a href="https://publications.waset.org/abstracts/search?q=Meslem%20Meriem"> Meslem Meriem</a>, <a href="https://publications.waset.org/abstracts/search?q=Maouchi%20Madiha"> Maouchi Madiha</a>, <a href="https://publications.waset.org/abstracts/search?q=Bahi%20Ahlem"> Bahi Ahlem</a>, <a href="https://publications.waset.org/abstracts/search?q=Benbia%20Souhila"> Benbia Souhila</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural extracts is known for their contents of biologically active molecules. In this context, we attempted to evaluate the antioxidant activity of the methanolic extract prepared from the bark of the roots of Zizyphus lotus. The quantitative analysis based on the dosage, phenolic compounds, flavonoids and tannins provided following values: 0.39 ± 0.007 ug EAG/mg of extract for phenolic compounds, 0.05 ± 0.02ug EQ/mg extract for flavonoids and 0.0025 ± 7.071 E-4 ECT ug/mg extract for tannins. The study of the antioxidant activity by the DPPH test in vitro showed a powerful antiradical power with an IC50 = 8,8 ug/ml. For the DPPH test in vivo we used two rats lots, one lot with a dose of 200 mg/kg of the methanol extract and a control lot. We found a significant difference in antiradical activity with p < 0.05. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zizyphus%20lotus" title="Zizyphus lotus">Zizyphus lotus</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPH" title=" DPPH"> DPPH</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20compounds" title=" phenolic compounds"> phenolic compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=tannins" title=" tannins"> tannins</a> </p> <a href="https://publications.waset.org/abstracts/5758/study-of-the-in-vivo-and-in-vitro-antioxidant-activity-of-the-methanol-extract-from-the-roots-of-the-barks-of-zizyphus-lotus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/5758.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">509</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7094</span> Study of Toxic Effect and Anti-Oxidative Activity of a β- Amidophosphonates</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Houria%20Djebar">Houria Djebar</a>, <a href="https://publications.waset.org/abstracts/search?q=Amina%20Saib"> Amina Saib</a>, <a href="https://publications.waset.org/abstracts/search?q=Malika%20Berredjem"> Malika Berredjem</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaoula%20Bechlem"> Khaoula Bechlem</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed-Reda%20Djebar"> Mohammed-Reda Djebar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reactive oxygen species (ROS) have a high potential to damage almost all types of cellular components of the body, which explains their involvement in the induction and/or amplification of several pathologies. Supplementation of the body by exogenous antioxidants is very useful against these harmful species. In this context, we attempted to evaluate the in vitro and in vivo antioxidant activities of three newly synthesized amidophosphonates (AP1, AP2, and AP3). The results relating to the in vitro tests for DPPH radical scavenging activity shows that these amidophosphonates have a modest antiradical power (ARP) less effectively pronounced compared with an analogue marketed in Algeria: (Dursban) Clorpiryphos ethyl. However, in vivo effects were evaluated on some antioxidant systems (LP intensity, CAT activity and GSH content), or in combination with 2, 2-diphenyl-picrylhydrazyle (DPPH) radical in paramecium tetraurelia used as a complementary system to rapidly elucidate the cytotoxicity. On the basis of the results obtained it can be concluded that amidophosphonates studied exhibited a mild protective effect. The mechanism for how they influenced the antioxidant activities was discussed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Paramecium%20tetraurelia" title="Paramecium tetraurelia">Paramecium tetraurelia</a>, <a href="https://publications.waset.org/abstracts/search?q=amidophosphonates" title=" amidophosphonates"> amidophosphonates</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPH%20free%20radical" title=" DPPH free radical"> DPPH free radical</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20experiments" title=" in vitro experiments"> in vitro experiments</a>, <a href="https://publications.waset.org/abstracts/search?q=biochemical%20parameters" title=" biochemical parameters"> biochemical parameters</a> </p> <a href="https://publications.waset.org/abstracts/106698/study-of-toxic-effect-and-anti-oxidative-activity-of-a-v-amidophosphonates" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106698.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">165</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7093</span> Assessing Digestive Enzymes Inhibitory Properties of Anthocyanins and Procyanidins from Apple, Red Grape, Cinnamon</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pinar%20Ercan">Pinar Ercan</a>, <a href="https://publications.waset.org/abstracts/search?q=Sedef%20N.%20El"> Sedef N. El</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The goals of this study were to determine the total anthocyanin and procyanidin contents and their in vitro bioaccessibilities of apple, red grape and cinnamon by a static in vitro digestion method reported by the COST FA1005 Action INFOGEST, as well as in vitro inhibitory effects of these food samples on starch and lipid digestive enzymes. While the highest total anthocyanin content was found in red grape (164.76 ± 2.51 mg/100 g), the highest procyanidin content was found in cinnamon (6432.54±177.31 mg/100 g) among the selected food samples (p<0.05). The anthocyanin bioaccessibilities were found as 10.23±1 %, 8.23±0.64 %, and 8.73±0.70 % in apple, red grape, and cinnamon, respectively. The procyanidin bioaccessibilities of apple, red grape, and cinnamon were found as 17.57±0.71 %, 14.08±0.74 % and 18.75±1.49 %, respectively. The analyzed apple, red grape and cinnamon showed the inhibitory activity against α-glucosidase (IC50 544.27±21.94, 445.63±15.67, 1592±17.58 μg/mL, respectively), α-amylase (IC50 38.41±7.26, 56.12±3.60, 3.54±0.86 μg/mL, respectively), and lipase (IC50 52.65±2.05, 581.70±54.14, 49.63±2.72 μg/mL, respectively). Red grape sample showed the highest inhibitory activity against α-glucosidase, cinnamon showed the highest inhibitory activity against α-amylase and lipase according to IC50 (concentration of inhibitor required to produce a 50% inhibition of the initial rate of reaction) and Catechin equivalent inhibition capacity (CEIC50) values. This study reported that apple, grape and cinnamon samples can inhibit the activity of digestive enzymes in vitro. The consumption of these samples would be used in conjunction with a low-calorie diet for body weight management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anthocyanin" title="anthocyanin">anthocyanin</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B1-amylase" title=" α-amylase"> α-amylase</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B1-glucosidase" title=" α-glucosidase"> α-glucosidase</a>, <a href="https://publications.waset.org/abstracts/search?q=lipase" title=" lipase"> lipase</a>, <a href="https://publications.waset.org/abstracts/search?q=procyanidin" title=" procyanidin"> procyanidin</a> </p> <a href="https://publications.waset.org/abstracts/81744/assessing-digestive-enzymes-inhibitory-properties-of-anthocyanins-and-procyanidins-from-apple-red-grape-cinnamon" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81744.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">181</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7092</span> In vitro Antioxidant and DNA Protectant Activity of Different Skin Colored Eggplant (Solanum melongena)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20M.%20Somawathie">K. M. Somawathie</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Rizliya"> V. Rizliya</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20A.%20M.%20Wickrmasinghe"> H. A. M. Wickrmasinghe</a>, <a href="https://publications.waset.org/abstracts/search?q=Terrence%20Madhujith"> Terrence Madhujith</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main objective of our study was to determine the in vitro antioxidant and DNA protectant activity of aqueous extract of S. melongena with different skin colors; dark purple (DP), moderately purple (MP), light purple (LP) and purple and green (PG). The antioxidant activity was evaluated using the DPPH and ABTS free radical scavenging assay, ferric reducing antioxidant power (FRAP), ferric thiocyanate (FTC) and the egg yolk model. The effectiveness of eggplant extracts against radical induced DNA damage was also determined. There was a significant difference (p < 0.0001) between the skin color and antioxidant activity. TPC and FRAP values of eggplant extracts ranged from 48.67±0.27-61.11±0.26 (mg GAE/100 g fresh weight) and 4.19±0.11-7.46±0.26 (mmol of FeS04/g of fresh weight) respectively. MP displayed the highest percentage of DPPH radical scavenging activity while, DP demonstrated the strongest total antioxidant capacity. In the FTC and egg yolk model, DP and MP showed better antioxidant activity than PG and LP. All eggplant extracts showed potent antioxidant activity in retaining DNA against AAPH mediated radical damage. DP and MP demonstrated better antioxidant activity which may be attributed to the higher phenolic content since a positive correlation was observed between the TPC and the antioxidant parameters. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Solanum%20melongena" title="Solanum melongena">Solanum melongena</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20color" title=" skin color"> skin color</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20protection" title=" DNA protection"> DNA protection</a>, <a href="https://publications.waset.org/abstracts/search?q=lipid%20peroxidation" title=" lipid peroxidation"> lipid peroxidation</a> </p> <a href="https://publications.waset.org/abstracts/35657/in-vitro-antioxidant-and-dna-protectant-activity-of-different-skin-colored-eggplant-solanum-melongena" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35657.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">431</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7091</span> In vitro and in vivo Antiangiogenic Activity of Girinimbine Isolated from Murraya koenigii</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Venoos%20Iman">Venoos Iman</a>, <a href="https://publications.waset.org/abstracts/search?q=Suzita%20Mohd%20Noor"> Suzita Mohd Noor</a>, <a href="https://publications.waset.org/abstracts/search?q=Syam%20Mohan"> Syam Mohan</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamad%20Ibrahim%20Noordin"> Mohamad Ibrahim Noordin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Girinimbine, a carbazole alkaloid was isolated from the stem bark and root of Murraya koenigii and its structure and purity was identified by HPLC and LC-MS. Here we report that Girinimbine strongly inhibit angiogenesis activity both in vitro and in vivo. MTT result showed that girinimbine inhibits cell proliferation of the HUVECS cell line in vitro. Result of endothelial cell invasion, migration, tube formation and wound healing assays also demonstrated significant time and does dependent inhibition by girinimbine. Moreover, girinibine mediates its anti-angiogenic activity through up- and down-regulation of angiogenic and anti-aniogenic proteins. Furthermore, anti-angiogenic potential of girinimbine was evidenced in vivo on zebrafish model. Girinimbine inhibited neo-vessels formation in zebrafish embryos during 24 hours exposure time. Together, these results demonstrated for the first time that girinimbine could effectively suppress angiogenesis and strongly suggest that it might be a novel angiogenesis inhibitor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anti-angiogenic" title="anti-angiogenic">anti-angiogenic</a>, <a href="https://publications.waset.org/abstracts/search?q=carbazole%20alkaloid" title=" carbazole alkaloid"> carbazole alkaloid</a>, <a href="https://publications.waset.org/abstracts/search?q=girinimbine" title=" girinimbine"> girinimbine</a>, <a href="https://publications.waset.org/abstracts/search?q=zebrafish" title=" zebrafish"> zebrafish</a> </p> <a href="https://publications.waset.org/abstracts/13579/in-vitro-and-in-vivo-antiangiogenic-activity-of-girinimbine-isolated-from-murraya-koenigii" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13579.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">376</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7090</span> Anti-cancer Activity of Cassava Leaves (Manihot esculenta Crantz.) Against Colon Cancer (WiDr) Cells in vitro</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatma%20Zuhrotun%20Nisa">Fatma Zuhrotun Nisa</a>, <a href="https://publications.waset.org/abstracts/search?q=Aprilina%20Ratriany"> Aprilina Ratriany</a>, <a href="https://publications.waset.org/abstracts/search?q=Agus%20Wijanarka"> Agus Wijanarka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Cassava leaves are widely used by the people of Indonesia as a vegetable and treat various diseases, including anticancer believed as food. However, not much research on the anticancer activity of cassava leaves, especially in colon cancer. Objectives: the aim of this study is to investigate anti-cancer activity of cassava leaves (Manihot esculanta C.) against colon cancer (WiDr) cells in vitro. Methods: effect of crude aqueous extract of leaves of cassava and cassava leaves boiled tested in colon cancer cells widr. Determination of Anticancer uses the MTT method with parameters such as the percentage of deaths. Results: raw cassava leaf water extract gave IC50 of 63.1 mg / ml. While the water extract of boiled cassava leaves gave IC50 of 79.4 mg/ml. However, there is no difference anticancer activity of raw cassava leaves or cancer (p> 0.05). Conclusion: Cassava leaves contain a variety of compounds that have previously been reported to have anticancer activity. Linamarin, β-carotene, vitamin C, and fiber were thought to affect the IC50 cassava leaf extract against colon cancer cells WiDr. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=boiled%20cassava%20leaves" title="boiled cassava leaves">boiled cassava leaves</a>, <a href="https://publications.waset.org/abstracts/search?q=cassava%20leaves%20raw" title=" cassava leaves raw"> cassava leaves raw</a>, <a href="https://publications.waset.org/abstracts/search?q=anticancer%20activity" title=" anticancer activity"> anticancer activity</a>, <a href="https://publications.waset.org/abstracts/search?q=colon%20cancer" title=" colon cancer"> colon cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=IC50" title=" IC50 "> IC50 </a> </p> <a href="https://publications.waset.org/abstracts/19756/anti-cancer-activity-of-cassava-leaves-manihot-esculenta-crantz-against-colon-cancer-widr-cells-in-vitro" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19756.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">551</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7089</span> Contribution to the Study of Some Phytochemicals and Biological Aspects of Artemisia absinthium L</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sihem%20Benmimoune">Sihem Benmimoune</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdelbaki%20Lemgharbi"> Abdelbaki Lemgharbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Ait%20Yahia"> Ahmed Ait Yahia</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdelkrim%20Kameli"> Abdelkrim Kameli </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Our study is based on chemical and phytochemical characterization of Artemisia absinthium L and in vitro tests to demonstrate the biological activities of essential oil and natural extract. A qualitative and quantitative comparison of the essential oil extracted by two extraction procedures was performed by analysis of CG/SM and the yield calculation. The method of hydrodistillation has a chemical composition and provides oil content than the best training water vapor. These oils are composed mainly of thujone followed chamazulene and ρ-cymene. The antimicrobial activity of wormwood oil was tested in vitro by two methods (agar diffusion and microdilution) on four plant pathogenic fungi (Aspergillus sp, Botrytis cinerea, Fusarium culmorum and Helminthosporium sp). The study of the antifungal effect showed that this oil has an inhibitory effect counterpart the microorganisms tested in particular the strain Botrytis cinerea. Otherwise, this activity depends on the nature of the oil and the germ itself. The antioxidant activity in vitro was studied with the DPPH method. The activity test shows that the oil and extract of Artemisia absinthium have a very low antioxidant capacity compared to the antioxidants used as a reference. The extract has a potentially high antiradical power not from its oil. The quantitative determinations of phenolic compounds by the Folin-Ciocalteu revealed that absinthe is low in total polyphenols and tannins. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=artemisia%20absinthium" title="artemisia absinthium">artemisia absinthium</a>, <a href="https://publications.waset.org/abstracts/search?q=biological%20activities" title=" biological activities"> biological activities</a>, <a href="https://publications.waset.org/abstracts/search?q=essential%20oil" title=" essential oil"> essential oil</a>, <a href="https://publications.waset.org/abstracts/search?q=extraction%20processes" title=" extraction processes"> extraction processes</a> </p> <a href="https://publications.waset.org/abstracts/39726/contribution-to-the-study-of-some-phytochemicals-and-biological-aspects-of-artemisia-absinthium-l" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39726.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">341</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7088</span> Extract and Naphthoquinone Derivatives from in vitro Culture of an Ascomycetous Marine Fungus with Antibacterial Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Uftah%20Ali%20M.%20Shushni">Uftah Ali M. Shushni</a>, <a href="https://publications.waset.org/abstracts/search?q=Viola%20Stuppec"> Viola Stuppec</a>, <a href="https://publications.waset.org/abstracts/search?q=Ulrike%20Lindequist"> Ulrike Lindequist</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Because of the evolving resistance of microorganisms to existing antibiotics, there is an increasing need for new antibiotics not only in human but also in veterinary medicine. As part of our ongoing work on the secondary metabolites produced by marine fungi, the organic extract of the culture filtrate of an Ascomycetous fungus, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany displayed antimicrobial activity against some fish and human pathogenic bacteria. Bioactivity-guided column chromatographic separation led to the isolation of 6-Deoxybostrycoidin. The structure was determined from the interpretation of spectroscopic data (UV, MS, and NMR). 6-Deoxybostrycoidin exhibited in vitro activity against Bacillus subtilis, Staphylococcus aureus and Flexibacter maritimus with minimal inhibitory concentrations of 25, 12.5 and 12.5 μg/ml respectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=marine%20fungi" title="marine fungi">marine fungi</a>, <a href="https://publications.waset.org/abstracts/search?q=fish%20pathogenic%20bacteria" title=" fish pathogenic bacteria"> fish pathogenic bacteria</a>, <a href="https://publications.waset.org/abstracts/search?q=microorganism" title=" microorganism"> microorganism</a>, <a href="https://publications.waset.org/abstracts/search?q=medicine" title=" medicine "> medicine </a> </p> <a href="https://publications.waset.org/abstracts/19261/extract-and-naphthoquinone-derivatives-from-in-vitro-culture-of-an-ascomycetous-marine-fungus-with-antibacterial-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19261.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">529</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7087</span> 2-Thioimidazole Analogues: Synthesis, in silico Studies and in vitro Anticancer and Antiprotozoal Evaluation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Drashti%20G.%20Daraji">Drashti G. Daraji</a>, <a href="https://publications.waset.org/abstracts/search?q=Rosa%20E.%20Moo-Puc"> Rosa E. Moo-Puc</a>, <a href="https://publications.waset.org/abstracts/search?q=Hitesh%20D.%20Patel"> Hitesh D. Patel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Substituted 2-Thioimidazole analogues have been synthesized and confirmed by advanced spectroscopic techniques. Among them, ten compounds have been selected and evaluated for their in vitro anti-cancer activity at the National Cancer Institute (NCI) for testing against a panel of 60 different human tumor cell lines derived from nine neoplastic cancer types. Furthermore, synthesized compounds were tested for their in vitro antiprotozoal activity, and none of them exhibited significant potency against antiprotozoans. It was observed that the tested all compounds seem effective on the UACC-62 melanoma cancer cell line as compared to other cancer cell lines and also exhibited the least potent in the Non-Small Cell Lung Cancer cell line in one-dose screening. In silico studies of these derivatives were carried out by molecular docking techniques and Absorption, Distribution, Metabolism, and Excretion (ADME) using Schrödinger software to find potent B-Raf kinase inhibitor (PDB ID: 3OG7). All the compounds have been performed for docking study; Compound D4 has a good docking score for melanoma cancer as compared with other. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anticancer%20activity" title="anticancer activity">anticancer activity</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20cell%20line" title=" cancer cell line"> cancer cell line</a>, <a href="https://publications.waset.org/abstracts/search?q=2-thio%20imidazole" title=" 2-thio imidazole"> 2-thio imidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=one-dose%20assay" title=" one-dose assay"> one-dose assay</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a> </p> <a href="https://publications.waset.org/abstracts/112257/2-thioimidazole-analogues-synthesis-in-silico-studies-and-in-vitro-anticancer-and-antiprotozoal-evaluation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/112257.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">143</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7086</span> Evaluation of Thrombolytic Activity of Zingiber cassumunar Roxb. and Thai Herbal Prasaplai Formula</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Warachate%20Khobjai">Warachate Khobjai</a>, <a href="https://publications.waset.org/abstracts/search?q=Suriyan%20Sukati"> Suriyan Sukati</a>, <a href="https://publications.waset.org/abstracts/search?q=Khemjira%20Jarmkom"> Khemjira Jarmkom</a>, <a href="https://publications.waset.org/abstracts/search?q=Pattaranut%20Eakwaropas"> Pattaranut Eakwaropas</a>, <a href="https://publications.waset.org/abstracts/search?q=Surachai%20Techaoei"> Surachai Techaoei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The propose of this study was to investigate <em>in vitro</em> thrombolytic activity of <em>Zingiber cassumunar</em> Roxb. and Prasaplai, a Thai herbal formulation of <em>Z. cassumunar</em> Roxb. Herbs were extracted with boiling water and concentrated by lyophilization. To observe their thrombolytic potential, an <em>in vitro</em> clot lysis method was applied where streptokinase and sterile distilled water were used as positive and negative controls, respectively. Crude aqueous extracts from <em>Z. cassumunar</em> Roxb. and Prasaplai formula showed significant thrombolytic activity by clot lysis of 17.90% and 25.21%, respectively, compared to the negative control water (5.16%) while the standard streptokinase revealed 64.78% clot lysis. These findings suggest that <em>Z. cassumunar</em> Roxb. exhibits moderate thrombolytic activity and cloud play an important role in the thrombolytic properties of Prasaplai formula. However, further study should be done to observe <em>in vivo</em> clot dissolving potential and to isolate active component(s) of these extracts. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thrombolytic%20activity" title="thrombolytic activity">thrombolytic activity</a>, <a href="https://publications.waset.org/abstracts/search?q=clot%20lysis" title=" clot lysis"> clot lysis</a>, <a href="https://publications.waset.org/abstracts/search?q=Zingiber%20cassumunar%20Roxb." title=" Zingiber cassumunar Roxb."> Zingiber cassumunar Roxb.</a>, <a href="https://publications.waset.org/abstracts/search?q=Prasaplai%20formula" title=" Prasaplai formula"> Prasaplai formula</a>, <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract" title=" aqueous extract"> aqueous extract</a> </p> <a href="https://publications.waset.org/abstracts/61567/evaluation-of-thrombolytic-activity-of-zingiber-cassumunar-roxb-and-thai-herbal-prasaplai-formula" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61567.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">338</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7085</span> In vitro and in vivo Assessment of Cholinesterase Inhibitory Activity of the Bark Extracts of Pterocarpus santalinus L. for the Treatment of Alzheimer’s Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Biswas">K. Biswas</a>, <a href="https://publications.waset.org/abstracts/search?q=U.%20H.%20Armin"> U. H. Armin</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20M.%20J.%20Prodhan"> S. M. J. Prodhan</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20A.%20Prithul"> J. A. Prithul</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Sarker"> S. Sarker</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Afrin"> F. Afrin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Alzheimer’s disease (AD) (a progressive neurodegenerative disorder) is mostly predominant cause of dementia in the elderly. Prolonging the function of acetylcholine by inhibiting both acetylcholinesterase and butyrylcholinesterase is most effective treatment therapy of AD. Traditionally <em>Pterocarpus santalinus</em> L. is widely known for its medicinal use. In this study, <em>in vitro</em> acetylcholinesterase inhibitory activity was investigated and methanolic extract of the plant showed significant activity. To confirm this activity (<em>in vivo</em>), learning and memory enhancing effects were tested in mice. For the test, memory impairment was induced by scopolamine (cholinergic muscarinic receptor antagonist). Anti-amnesic effect of the extract was investigated by the passive avoidance task in mice. The study also includes brain acetylcholinesterase activity. Results proved that scopolamine induced cognitive dysfunction was significantly decreased by administration of the extract solution, in the passive avoidance task and inhibited brain acetylcholinesterase activity. These results suggest that bark extract of <em>Pterocarpus santalinus</em> can be better option for further studies on AD via their acetylcholinesterase inhibitory actions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pterocarpus%20santalinus" title="Pterocarpus santalinus">Pterocarpus santalinus</a>, <a href="https://publications.waset.org/abstracts/search?q=cholinesterase%20inhibitor" title=" cholinesterase inhibitor"> cholinesterase inhibitor</a>, <a href="https://publications.waset.org/abstracts/search?q=passive%20avoidance" title=" passive avoidance"> passive avoidance</a>, <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%E2%80%99s%20disease" title=" Alzheimer’s disease"> Alzheimer’s disease</a> </p> <a href="https://publications.waset.org/abstracts/97700/in-vitro-and-in-vivo-assessment-of-cholinesterase-inhibitory-activity-of-the-bark-extracts-of-pterocarpus-santalinus-l-for-the-treatment-of-alzheimers-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/97700.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">249</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7084</span> In vitro and invivo Antioxidant Studies of Grewia crenata Leaves Extract in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20N.Ukwuani">A. N.Ukwuani</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20K.%20Abdulfatah"> A. K. Abdulfatah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> G. crenata is used locally for the treatment of fractured bones, wound healing and inflammatory conditions. In vitro and in vivo antioxidant activity of hydromethanolic extracts of the leaves of G. crenata were assessed. The phytochemical analysis shows the presence of phenols, flavonoids, saponins, cardiac glycosides and tannins. An in vitro quantitative analysis of phenols, flavonoids and tannins respectively were (164±1.20, 199±0.88 and 88.67±0.88 mg/100g FW). In vivo studies of hydromethanolic extract demonstrated a dose dependent increase in hepatic superoxide dismutase (1.14±0.14, 2.13±0.11, 2.55±0.11 U/mg Protein) with improvement in hepatic glutathione (6.98±0.42, 8.91±0.37, 11.07±0.46 µM/mg Protein) and Catalase (4.47±0.05, 6.24±0.02, 7.17±0.04 U/mg Protein) and Total protein (6.18±0.08, 6.69±0.18, 7.27±0.16 mg/ml) respectively at 100-300mg/kg body weight Grewia crenata leaves when compared to the control and standard drug. It can be concluded from the present findings of that G. crenata leaves possess antioxidant potential. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Grewia%20crenata" title="Grewia crenata">Grewia crenata</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=hydromethanolic%20extract" title=" hydromethanolic extract"> hydromethanolic extract</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vivo" title=" in vivo"> in vivo</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro" title=" in vitro"> in vitro</a> </p> <a href="https://publications.waset.org/abstracts/15568/in-vitro-and-invivo-antioxidant-studies-of-grewia-crenata-leaves-extract-in-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15568.pdf" 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