1 Genomic Test Can Diagnose Nearly Any Infection

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <title>1 Genomic Test Can Diagnose Nearly Any Infection | UC San Francisco</title> <meta charset="utf-8" /> <meta name="description" content="A decade-long effort has resulted in a new, rapid genomic test to diagnose rare infectious diseases in the brain and lungs." /> <meta name="abstract" content="A decade-long effort has resulted in a new, rapid genomic test to diagnose rare infectious diseases in the brain and lungs." /> <link rel="canonical" href="https://www.ucsf.edu/news/2024/11/428831/1-genomic-test-can-diagnose-nearly-any-infection" /> <link rel="image_src" href="https://www.ucsf.edu/sites/default/files/2024-11/charles-chiu-dna-extraction.jpg" /> <meta property="og:site_name" content="1 Genomic Test Can Diagnose Nearly Any Infection | UC San Francisco" /> <meta property="og:type" content="news" /> <meta property="og:url" content="https://www.ucsf.edu/news/2024/11/428831/1-genomic-test-can-diagnose-nearly-any-infection" /> <meta property="og:title" content="1 Genomic Test Can Diagnose Nearly Any Infection" /> <meta property="og:description" content="A decade-long effort has resulted in a new, rapid genomic test to diagnose rare infectious diseases in the brain and lungs." /> <meta property="og:image" content="https://www.ucsf.edu/sites/default/files/2024-11/charles-chiu-dna-extraction.jpg" /> <meta property="og:image:secure_url" content="https://www.ucsf.edu/sites/default/files/2024-11/charles-chiu-dna-extraction.jpg" /> <meta property="og:image:type" content="image/jpeg" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:description" content="A decade-long effort has resulted in a new, rapid genomic test to diagnose rare infectious diseases in the brain and lungs." /> <meta name="twitter:site" content="@ucsf" /> <meta name="twitter:title" content="1 Genomic Test Can Diagnose Nearly Any Infection" /> <meta name="twitter:creator" content="@ucsf" /> <meta name="twitter:image" content="https://www.ucsf.edu/sites/default/files/2024-11/charles-chiu-dna-extraction.jpg" /> <meta name="twitter:image:alt" content="||||" /> <meta name="google-site-verification" content="rSaM6CprJQndLnVGSxg0oZ-oB85lajeVcjE1fQzK1-I" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <script type="application/ld+json">{ "@context": "https://schema.org", "@graph": [ { "@type": "NewsArticle", "headline": "1 Genomic Test Can Diagnose Nearly Any Infection", "name": "1 Genomic Test Can Diagnose Nearly Any Infection | UC San Francisco", "description": "A decade-long effort has resulted in a new, rapid genomic test to diagnose rare infectious diseases in the brain and lungs.", "image": { "@type": "ImageObject", "representativeOfPage": "True", "url": "https://www.ucsf.edu/sites/default/files/2024-11/charles-chiu-dna-extraction.jpg", "width": "940", "height": "481" }, "datePublished": "2024-11-05T17:28:53-0800", "dateModified": "2024-11-05T17:28:53-0800", "author": { "@type": "Organization", "@id": "https://www.ucsf.edu/", "name": "University of California San Francisco", "url": "https://www.ucsf.edu/", "sameAs": "https://twitter.com/ucsf, https://www.facebook.com/ucsf, https://instagram.com/ucsf, https://www.youtube.com/ucsf, https://www.linkedin.com/school/ucsf", "logo": { "@type": "ImageObject", "representativeOfPage": "True", "url": "https://www.ucsf.edu/themes/custom/ucsf/assets/images/ucsf_logo_navy_for_google_structured_data.png", "width": "360", "height": "174" } }, "publisher": { "@type": "Organization", "@id": "https://www.ucsf.edu/", "name": "University of California San Francisco", "url": "https://www.ucsf.edu/", "sameAs": "https://twitter.com/ucsf, https://www.facebook.com/ucsf, https://instagram.com/ucsf, https://www.youtube.com/ucsf, https://www.linkedin.com/school/ucsf", "logo": { "@type": "ImageObject", "representativeOfPage": "True", "url": "https://www.ucsf.edu/themes/custom/ucsf/assets/images/ucsf_logo_navy_for_google_structured_data.png", "width": "360", "height": "174" } }, "mainEntityOfPage": "https://www.ucsf.edu/news/2024/11/428831/1-genomic-test-can-diagnose-nearly-any-infection" } ] }</script> <meta itemprop="acquia_lift:content_title" content="1 Genomic Test Can Diagnose Nearly Any Infection" /> <meta itemprop="acquia_lift:content_type" content="article" /> <meta itemprop="acquia_lift:page_type" content="node page" /> <meta itemprop="acquia_lift:language" content="en" /> <meta itemprop="acquia_lift:content_section" content="" /> <meta itemprop="acquia_lift:content_keywords" content="" /> <meta itemprop="acquia_lift:post_id" content="428831" /> <meta itemprop="acquia_lift:content_uuid" content="78e66604-b7e3-42ac-918d-4d9145c44d90" /> <meta itemprop="acquia_lift:published_date" content="1730856533" /> <meta itemprop="acquia_lift:persona" content="" /> <meta itemprop="acquia_lift:engagement_score" content="1" /> <meta itemprop="acquia_lift:account_id" content="UCSF" /> <meta itemprop="acquia_lift:site_id" content="ucsfedu" /> <meta itemprop="acquia_lift:liftAssetsURL" content="https://builder.lift.acquia.com" /> <meta itemprop="acquia_lift:liftDecisionAPIURL" content="https://us.perz-api.cloudservices.acquia.io" /> <meta itemprop="acquia_lift:bootstrapMode" content="auto" /> <meta itemprop="acquia_lift:contentReplacementMode" content="trusted" /> <meta itemprop="acquia_lift:apiVersion" content="v3" /> <script src="https://builder.lift.acquia.com/lift.js" async></script> <link rel="icon" href="/themes/custom/ucsf/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preload" href="/themes/custom/ucsf/fonts/GranjonLTW01-Roman.woff2" as="font" crossorigin /> <link rel="preload" href="/themes/custom/ucsf/fonts/HelveticaNeueLTW04-45Light.woff2" as="font" crossorigin /> <link rel="preload" href="/themes/custom/ucsf/fonts/HelveticaNeueLTW04-55Roman.woff2" as="font" crossorigin /> <link rel="preload" href="/themes/custom/ucsf/fonts/HelveticaNeueLTW04-56Italic.woff2" as="font" crossorigin /> <link rel="preload" href="/themes/custom/ucsf/fonts/HelveticaNeueLTW04-65Medium.woff2" as="font" crossorigin /> <link rel="preload" href="/themes/custom/ucsf/fonts/HelveticaNeueLTW06-75Bold.woff2" as="font" crossorigin /> <script src="/sites/default/files/google_tag/primary/google_tag.script.js?snbnwj" defer></script> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_6qs8ImL86MZ-HjOTEZrOFd_jO1iOnc0b9bgBBD_oqy8.css?delta=0&language=en&theme=ucsf&include=eJxlkFtuAyEMRTdEh48uCHnAmXFjMMImKV19yEOJRv2x0AF8j248YyKTFsa3UajcNyrqr7hGyVUKFlOXwIBhYPMr7nAhaepUIgGHPH9DYCpn9f_RYjtmdDrUMPsVFF1kUB2Hc0ZV2FBdlIa-SMvA9IeuRz35jWUFdkO69RXDBszYxgt_qY0ZtDk1MFKjqD61XoGXD3EXwqv6x1yypM54QPADv88s5GlbLJwg4ZHoVUT3J7uPAG2uZgwmdUaEad4wWtgR0t2nQoOtQd3fPh-y9FL7yqQ7JncittlrhGok5RgqF2wMNSS0uft9_ch_dU1Rir5woflegRWhxadrgCSzNCjA41HOB94A9j3G5w" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_d3zMBqhbzEuXhe0NGNKEjFfiJ6wRrce_6DpOq2twhpc.css?delta=1&language=en&theme=ucsf&include=eJxlkFtuAyEMRTdEh48uCHnAmXFjMMImKV19yEOJRv2x0AF8j248YyKTFsa3UajcNyrqr7hGyVUKFlOXwIBhYPMr7nAhaepUIgGHPH9DYCpn9f_RYjtmdDrUMPsVFF1kUB2Hc0ZV2FBdlIa-SMvA9IeuRz35jWUFdkO69RXDBszYxgt_qY0ZtDk1MFKjqD61XoGXD3EXwqv6x1yypM54QPADv88s5GlbLJwg4ZHoVUT3J7uPAG2uZgwmdUaEad4wWtgR0t2nQoOtQd3fPh-y9FL7yqQ7JncittlrhGok5RgqF2wMNSS0uft9_ch_dU1Rir5woflegRWhxadrgCSzNCjA41HOB94A9j3G5w" /> <script>if (!window.customElements) { document.write(' <script type="text/javascript" src="/modules/custom/ckeditor_y3ti_plugins/bower_components/webcomponentsjs/custom-elements-es5-adapter.js"></script>  <script src="/modules/custom/ckeditor_y3ti_plugins/bower_components/webcomponentsjs/webcomponents-loader.js?snbnwj"></script> <script src="/modules/custom/ucsf_adobe_analytics/js/ucsf-data-layer.js?snbnwj" defer></script> <script src="/modules/custom/ucsf_adobe_analytics/js/ucsf-mag-marketing-data-layer.js?snbnwj" defer></script> <script src="https://assets.adobedtm.com/db5f13cb240b/b1130ce1ceae/launch-db8f55f3e131.min.js" defer></script> </head> <body class="alias-news-2024-11-428831-1-genomic-test-can-diagnose-nearly-any-infection path-node page-node-type-article loading"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-TSHCJ6" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="page"> <header class="combined-header-region "> <section class="universal-header-region"> <div class="universal-header"> <p id="site-name" class="universal-header__title">University of California San Francisco</p> <a href="https://giving.ucsf.edu" class="universal-header__give">Give to UCSF</a> </div> </section> <section class="header-region"> <div class="header "> <figure class="header--logo logo"> <a class="logo__link" href="/" title="Home" rel="home"> <picture class="logo__image"> <img fetchpriority="high" class="logo__img" src="/themes/custom/ucsf/logo.svg" alt="Home" height="41" width="83"> </picture> </a> </figure> <div class="header--search menu-item"><a href="/search" role="button" class="nolink mobile-search-reveal "><span>Search</span></a> <div class="home-search__form "> <form action="/search" accept-charset="utf-8" method="get" class="search__form"> <label for="header-search" class="visually-hidden">Small screen search</label> <input type="text" name="search" id="header-search" size="32" class="home-search__form-input " value="" placeholder="Search people, places, ideas" /> <input type="submit" id="edit-submit-header" name="op" value="Search" class="home-search__form-submit "> <fieldset class="fieldset-reset"> <legend class="visually-hidden">Choose what type of search to perform</legend> <div class="search-filter"> <label for="allucsf"> <input id="allucsf" type="radio" name="filter" class="visually-hidden search-filter__radio" value="All" checked> <div class="search-filter__label"> <span class="search-filter__option"></span> <span>All UCSF</span> </div> </label> <label for="newscenter"> <input id="newscenter" type="radio" name="filter" class="visually-hidden search-filter__radio" value="News"> <div class="search-filter__label"> <span class="search-filter__option"></span> <span>UCSF News Center</span> </div> </label> </div> </fieldset> </form> </div> </div> <div class="slicknav-placeholder"></div> <nav aria-label="Main" id="block-ucsf-main-menu" class="block block-menu navigation menu--main main-menu--mobile main-nav"> <ul block="block-ucsf-main-menu" class="menu-parent-wrapper"> <li class="menu-item menu-item--expanded menu-top-level__item" > <a href="https://www.ucsf.edu/about" class="nolink" data-drupal-link-system-path="node/130301">About</a> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/about" title="UCSF Overview" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/130301">Overview</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/about/mission-and-values" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/406481">Mission & Values</a> </li> <li class="menu-item menu-item--expanded dropdown-menu__item" > <span class="main-navigation__link dropdown-menu__link">Our Impact</span> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/about/achievements" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/413636">Achievements</a> </li> <li class="menu-item dropdown-menu__item" > <a href="/about/community-benefits" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="taxonomy/term/629">UCSF in the Community</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/about/history-1" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/93484">History</a> </li> <li class="menu-item menu-item--expanded dropdown-menu__item" > <span class="main-navigation__link dropdown-menu__link">Facts & Figures</span> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/about/ucsf-budget" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/403036">Budget</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/about/innovation" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/413691">Inventions & Entrepreneurship</a> </li> <li class="menu-item dropdown-menu__item" > <a href="/sites/default/files/2024-03/UCSF-General-Fact-Sheet-March-2024.pdf" class="main-navigation__link dropdown-menu__link">UCSF Fact Sheet</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item menu-item--expanded dropdown-menu__item" > <span class="main-navigation__link dropdown-menu__link">Administration</span> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://chancellor.ucsf.edu/leadership/chancellors-cabinet" target="_blank">Campus Leaders</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://chancellor.ucsf.edu/chancellor" class="main-navigation__link dropdown-menu__link">Chancellor</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://evcprovost.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Executive Vice Chancellor & Provost</a> </li> <li class="menu-item dropdown-menu__item" > <a href="/cgr" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/93347">Community & Government Relations</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://diversity.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Diversity & Outreach</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://fas.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Finance & Administrative Services</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://legal.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Legal Affairs</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/office-of-communications" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/423371">Office of Communications</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://giving.ucsf.edu/" class="main-navigation__link dropdown-menu__link">University Development & Alumni Relations</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/about/locations" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/96416">Locations</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item menu-item--expanded menu-top-level__item" > <a href="https://www.ucsf.edu/patient-care" class="nolink" data-drupal-link-system-path="node/130356">Patient Care</a> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/patient-care" title="Patient Care Overview" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/130356">Overview</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsfhealth.org/" class="main-navigation__link dropdown-menu__link">UCSF Health</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsfbenioffchildrens.org/" class="main-navigation__link dropdown-menu__link">UCSF Benioff Children’s Hospitals</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsfdentalcenter.org/" class="main-navigation__link dropdown-menu__link">UCSF Dental Center</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://psych.ucsf.edu/lpphc" class="main-navigation__link dropdown-menu__link">Langley Porter Psychiatric Hospital and Clinics</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsfhealth.org/clinics" class="main-navigation__link dropdown-menu__link">Specialty Clinics</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/patient-care/clinical-trials" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/93456">Clinical Trials</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item menu-item--expanded menu-top-level__item" > <a href="https://www.ucsf.edu/research" class="nolink" data-drupal-link-system-path="node/130351">Research</a> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/research" title="Research Overview" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/130351">Overview</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/research/partnerships" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/130491">Partnerships</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://research.ucsf.edu" class="main-navigation__link dropdown-menu__link">Office of Research</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://innovation.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Innovation Ventures</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://postdocs.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Postdoctoral Scholars</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item menu-item--expanded menu-top-level__item" > <a href="https://www.ucsf.edu/education" class="nolink" data-drupal-link-system-path="node/130311">Education</a> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/education" title="Education Overview" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/130311">Overview</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/education/admissions" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/409171">Admissions</a> </li> <li class="menu-item menu-item--expanded dropdown-menu__item" > <span class="main-navigation__link dropdown-menu__link">Schools & Programs</span> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="http://dentistry.ucsf.edu/" title="School of Dentistry" class="main-navigation__link dropdown-menu__link">School of Dentistry</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://medschool.ucsf.edu" title="School of Medicine" class="main-navigation__link dropdown-menu__link">School of Medicine</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://pharmacy.ucsf.edu" title="School Pharmacy" class="main-navigation__link dropdown-menu__link">School of Pharmacy</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://nursing.ucsf.edu" title="School of Nursing" class="main-navigation__link dropdown-menu__link">School of Nursing</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://graduate.ucsf.edu" title="Graduate Education" class="main-navigation__link dropdown-menu__link">Graduate Division</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://globalhealthsciences.ucsf.edu" title="Global Health Sciences" class="main-navigation__link dropdown-menu__link">Global Health Sciences</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item menu-item--expanded dropdown-menu__item" > <span class="main-navigation__link dropdown-menu__link">Resources for Students</span> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://registrar.ucsf.edu/academic-calendar" class="main-navigation__link dropdown-menu__link">Academic Calendar</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://career.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Career Center</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://finaid.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Financial Aid</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://catalog.ucsf.edu/" class="main-navigation__link dropdown-menu__link">General Catalog</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.library.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Library</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://registrar.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Registrar</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://success.ucsf.edu/" class="main-navigation__link dropdown-menu__link">Student Success Guide</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item menu-item--expanded menu-top-level__item" > <a href="https://www.ucsf.edu/news" class="nolink" data-drupal-link-system-path="node/413561">News & Media</a> <ul class="menu-child-wrapper"> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/news" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/413561">UCSF News Center</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://magazine.ucsf.edu/magazine" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/418411">UCSF Magazine</a> </li> <li class="menu-item dropdown-menu__item" > <a href="/campus-news" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="taxonomy/term/1006">Campus News</a> </li> <li class="menu-item dropdown-menu__item" > <a href="/news/media-coverage" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="taxonomy/term/413496">Media Coverage</a> </li> <li class="menu-item dropdown-menu__item" > <a href="https://www.ucsf.edu/news-media/journalists" class="main-navigation__link dropdown-menu__link" data-drupal-link-system-path="node/130226">Resources for Journalists</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </li> <li class="menu-item search menu-top-level__item" > <a href="/search" class="main-navigation__link" data-drupal-link-system-path="search">Search</a> </li> </ul> <div class="universal-header__give-mobile"> <a class="universal-header__give" href="https://giving.ucsf.edu">Give to UCSF</a> </div> </nav> <nav aria-label="Main" id="block-ucsf-main-menu-desktop" class="block block-menu navigation menu--main main-nav"> <ul block="block-ucsf-main-menu-desktop" class="main-nav__menu"> <li class="menu-item menu-item--expanded main-nav__submenu-wrapper" > <button class="main-nav__toggle menu-item-about-menu" aria-controls="aria-about-menu" aria-expanded=false > About </button> <div id="aria-about-menu" aria-labelledby="aria-label-about-menu" class="main-submenu main-submenu--0" data-level="level-0"> <button class="menu-item-close" aria-controls="aria-about-menu" aria-expanded=false> Close About menu. </button> <div data-section="section-about-menu" class="main-submenu__label main-submenu__label--0"> <span id="aria-label-about-menu" class="main-submenu__label-text">About</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/about" title="UCSF Overview" data-drupal-link-system-path="node/130301"> <span>Overview</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/about/mission-and-values" data-drupal-link-system-path="node/406481"> <span>Mission & Values</span> </a> </li> <li class="menu-item menu-item--expanded" > <button class="main-submenu__toggle menu-item-our-impact" aria-controls="aria-our-impact" aria-expanded=false > Our Impact </button> <span class="fas fa-angle-right"></span> <div id="aria-our-impact" aria-labelledby="aria-label-our-impact" class="main-submenu main-submenu--1" data-level="level-1"> <div data-section="section-our-impact" class="main-submenu__label"> <span id="aria-label-our-impact" class="main-submenu__label-text">Our Impact</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/about/achievements" data-drupal-link-system-path="node/413636"> <span>Achievements</span> </a> </li> <li class="menu-item" > <a href="/about/community-benefits" data-drupal-link-system-path="taxonomy/term/629"> <span>UCSF in the Community</span> </a> </li> </ul> </div> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/about/history-1" data-drupal-link-system-path="node/93484"> <span>History</span> </a> </li> <li class="menu-item menu-item--expanded" > <button class="main-submenu__toggle menu-item-facts--figures" aria-controls="aria-facts--figures" aria-expanded=false > Facts & Figures </button> <span class="fas fa-angle-right"></span> <div id="aria-facts--figures" aria-labelledby="aria-label-facts--figures" class="main-submenu main-submenu--1" data-level="level-1"> <div data-section="section-facts--figures" class="main-submenu__label"> <span id="aria-label-facts--figures" class="main-submenu__label-text">Facts & Figures</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/about/ucsf-budget" data-drupal-link-system-path="node/403036"> <span>Budget</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/about/innovation" data-drupal-link-system-path="node/413691"> <span>Inventions & Entrepreneurship</span> </a> </li> <li class="menu-item" > <a href="/sites/default/files/2024-03/UCSF-General-Fact-Sheet-March-2024.pdf"> <span>UCSF Fact Sheet</span> </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded" > <button class="main-submenu__toggle menu-item-administration" aria-controls="aria-administration" aria-expanded=false > Administration </button> <span class="fas fa-angle-right"></span> <div id="aria-administration" aria-labelledby="aria-label-administration" class="main-submenu main-submenu--1" data-level="level-1"> <div data-section="section-administration" class="main-submenu__label"> <span id="aria-label-administration" class="main-submenu__label-text">Administration</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://chancellor.ucsf.edu/leadership/chancellors-cabinet"> <span>Campus Leaders</span> </a> </li> <li class="menu-item" > <a href="https://chancellor.ucsf.edu/chancellor"> <span>Chancellor</span> </a> </li> <li class="menu-item" > <a href="https://evcprovost.ucsf.edu/"> <span>Executive Vice Chancellor & Provost</span> </a> </li> <li class="menu-item" > <a href="/cgr" data-drupal-link-system-path="node/93347"> <span>Community & Government Relations</span> </a> </li> <li class="menu-item" > <a href="https://diversity.ucsf.edu/"> <span>Diversity & Outreach</span> </a> </li> <li class="menu-item" > <a href="https://fas.ucsf.edu/"> <span>Finance & Administrative Services</span> </a> </li> <li class="menu-item" > <a href="https://legal.ucsf.edu/"> <span>Legal Affairs</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/office-of-communications" data-drupal-link-system-path="node/423371"> <span>Office of Communications</span> </a> </li> <li class="menu-item" > <a href="https://giving.ucsf.edu/"> <span>University Development & Alumni Relations</span> </a> </li> </ul> </div> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/about/locations" data-drupal-link-system-path="node/96416"> <span>Locations</span> </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded main-nav__submenu-wrapper" > <button class="main-nav__toggle menu-item-patient-care" aria-controls="aria-patient-care" aria-expanded=false > Patient Care </button> <div id="aria-patient-care" aria-labelledby="aria-label-patient-care" class="main-submenu main-submenu--0" data-level="level-0"> <button class="menu-item-close" aria-controls="aria-patient-care" aria-expanded=false> Close Patient Care menu. </button> <div data-section="section-patient-care" class="main-submenu__label main-submenu__label--0"> <span id="aria-label-patient-care" class="main-submenu__label-text">Patient Care</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/patient-care" title="Patient Care Overview" data-drupal-link-system-path="node/130356"> <span>Overview</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsfhealth.org/"> <span>UCSF Health</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsfbenioffchildrens.org/"> <span>UCSF Benioff Children’s Hospitals</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsfdentalcenter.org/"> <span>UCSF Dental Center</span> </a> </li> <li class="menu-item" > <a href="https://psych.ucsf.edu/lpphc"> <span>Langley Porter Psychiatric Hospital and Clinics</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsfhealth.org/clinics"> <span>Specialty Clinics</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/patient-care/clinical-trials" data-drupal-link-system-path="node/93456"> <span>Clinical Trials</span> </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded main-nav__submenu-wrapper" > <button class="main-nav__toggle menu-item-research" aria-controls="aria-research" aria-expanded=false > Research </button> <div id="aria-research" aria-labelledby="aria-label-research" class="main-submenu main-submenu--0" data-level="level-0"> <button class="menu-item-close" aria-controls="aria-research" aria-expanded=false> Close Research menu. </button> <div data-section="section-research" class="main-submenu__label main-submenu__label--0"> <span id="aria-label-research" class="main-submenu__label-text">Research</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/research" title="Research Overview" data-drupal-link-system-path="node/130351"> <span>Overview</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/research/partnerships" data-drupal-link-system-path="node/130491"> <span>Partnerships</span> </a> </li> <li class="menu-item" > <a href="https://research.ucsf.edu"> <span>Office of Research</span> </a> </li> <li class="menu-item" > <a href="https://innovation.ucsf.edu/"> <span>Innovation Ventures</span> </a> </li> <li class="menu-item" > <a href="https://postdocs.ucsf.edu/"> <span>Postdoctoral Scholars</span> </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded main-nav__submenu-wrapper" > <button class="main-nav__toggle menu-item-education" aria-controls="aria-education" aria-expanded=false > Education </button> <div id="aria-education" aria-labelledby="aria-label-education" class="main-submenu main-submenu--0" data-level="level-0"> <button class="menu-item-close" aria-controls="aria-education" aria-expanded=false> Close Education menu. </button> <div data-section="section-education" class="main-submenu__label main-submenu__label--0"> <span id="aria-label-education" class="main-submenu__label-text">Education</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/education" title="Education Overview" data-drupal-link-system-path="node/130311"> <span>Overview</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/education/admissions" data-drupal-link-system-path="node/409171"> <span>Admissions</span> </a> </li> <li class="menu-item menu-item--expanded" > <button class="main-submenu__toggle menu-item-schools--programs" aria-controls="aria-schools--programs" aria-expanded=false > Schools & Programs </button> <span class="fas fa-angle-right"></span> <div id="aria-schools--programs" aria-labelledby="aria-label-schools--programs" class="main-submenu main-submenu--1" data-level="level-1"> <div data-section="section-schools--programs" class="main-submenu__label"> <span id="aria-label-schools--programs" class="main-submenu__label-text">Schools & Programs</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="http://dentistry.ucsf.edu/" title="School of Dentistry"> <span>School of Dentistry</span> </a> </li> <li class="menu-item" > <a href="https://medschool.ucsf.edu" title="School of Medicine"> <span>School of Medicine</span> </a> </li> <li class="menu-item" > <a href="https://pharmacy.ucsf.edu" title="School Pharmacy"> <span>School of Pharmacy</span> </a> </li> <li class="menu-item" > <a href="https://nursing.ucsf.edu" title="School of Nursing"> <span>School of Nursing</span> </a> </li> <li class="menu-item" > <a href="https://graduate.ucsf.edu" title="Graduate Education"> <span>Graduate Division</span> </a> </li> <li class="menu-item" > <a href="https://globalhealthsciences.ucsf.edu" title="Global Health Sciences"> <span>Global Health Sciences</span> </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded" > <button class="main-submenu__toggle menu-item-resources-for-students" aria-controls="aria-resources-for-students" aria-expanded=false > Resources for Students </button> <span class="fas fa-angle-right"></span> <div id="aria-resources-for-students" aria-labelledby="aria-label-resources-for-students" class="main-submenu main-submenu--1" data-level="level-1"> <div data-section="section-resources-for-students" class="main-submenu__label"> <span id="aria-label-resources-for-students" class="main-submenu__label-text">Resources for Students</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://registrar.ucsf.edu/academic-calendar"> <span>Academic Calendar</span> </a> </li> <li class="menu-item" > <a href="https://career.ucsf.edu/"> <span>Career Center</span> </a> </li> <li class="menu-item" > <a href="https://finaid.ucsf.edu/"> <span>Financial Aid</span> </a> </li> <li class="menu-item" > <a href="https://catalog.ucsf.edu/"> <span>General Catalog</span> </a> </li> <li class="menu-item" > <a href="https://www.library.ucsf.edu/"> <span>Library</span> </a> </li> <li class="menu-item" > <a href="https://registrar.ucsf.edu/"> <span>Registrar</span> </a> </li> <li class="menu-item" > <a href="https://success.ucsf.edu/"> <span>Student Success Guide</span> </a> </li> </ul> </div> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded main-nav__submenu-wrapper" > <button class="main-nav__toggle menu-item-news--media" aria-controls="aria-news--media" aria-expanded=false > News & Media </button> <div id="aria-news--media" aria-labelledby="aria-label-news--media" class="main-submenu main-submenu--0" data-level="level-0"> <button class="menu-item-close" aria-controls="aria-news--media" aria-expanded=false> Close News & Media menu. </button> <div data-section="section-news--media" class="main-submenu__label main-submenu__label--0"> <span id="aria-label-news--media" class="main-submenu__label-text">News & Media</span> </div> <ul class="main-submenu__menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/news" data-drupal-link-system-path="node/413561"> <span>UCSF News Center</span> </a> </li> <li class="menu-item" > <a href="https://magazine.ucsf.edu/magazine" data-drupal-link-system-path="node/418411"> <span>UCSF Magazine</span> </a> </li> <li class="menu-item" > <a href="/campus-news" data-drupal-link-system-path="taxonomy/term/1006"> <span>Campus News</span> </a> </li> <li class="menu-item" > <a href="/news/media-coverage" data-drupal-link-system-path="taxonomy/term/413496"> <span>Media Coverage</span> </a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/news-media/journalists" data-drupal-link-system-path="node/130226"> <span>Resources for Journalists</span> </a> </li> </ul> </div> </li> <li class="menu-item search" > <button class="main-nav__toggle menu-item-search-menu" aria-controls="aria-search-menu" aria-expanded=false > Open or Close Search Form </button> <div id="aria-search-menu" class="main-submenu main-nav__search"> <div class="home-search__form"> <form action="/search" accept-charset="utf-8" method="get" class="search__form"> <label for="header-desktop-search" class="visually-hidden">search</label> <input type="text" name="search" id="header-desktop-search" size="32" class="home-search__form-input" value="" placeholder="Search people, places, ideas" /> <fieldset class="fieldset-reset"> <legend class="visually-hidden">Choose what type of search to perform</legend> <div class="search-filter"> <label> <input type="radio" name="filter" class="visually-hidden search-filter__radio" value="All" checked> <div class="search-filter__label"> <span class="search-filter__option"></span> <span>All UCSF</span> </div> </label> <label> <input type="radio" name="filter" class="visually-hidden search-filter__radio" value="News"> <div class="search-filter__label"> <span class="search-filter__option"></span> <span>UCSF News Center</span> </div> </label> </div> </fieldset> <input type="submit" id="edit-submit" name="op" value="Search" class="home-search__form-submit"> </form> </div> </div> </li> </ul> </nav> </div> </section> </header> <div class="help"> <div class="region-highlighted"> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> <div class="region-content"> <div id="block-ucsf-content" class="block block-system block-system-main-block"> <main class="main "> <a id="main-content" tabindex="-1"></a> <div data-history-node-id="428831" class="article-feature-overlay-banner featureoverlaydark"> <figure class="article-feature-overlay-image"> <figure> <picture class="field field-banner-image field--type-entity-reference field--label-hidden field__item"> <source srcset="/sites/default/files/styles/article_feature_banner__image/public/2024-11/charles-chiu-dna-extraction.jpg 1x, /sites/default/files/styles/feature_banner_2x/public/2024-11/charles-chiu-dna-extraction.jpg 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="1440" height="780"/> <source srcset="/sites/default/files/styles/feature_banner_large/public/2024-11/charles-chiu-dna-extraction.jpg 1x, /sites/default/files/styles/feature_banner_2x/public/2024-11/charles-chiu-dna-extraction.jpg 2x" media="all and (min-width: 1050px) and (max-width: 1280px)" type="image/jpeg" width="1280" height="693"/> <source srcset="/sites/default/files/styles/feature_banner_medium/public/2024-11/charles-chiu-dna-extraction.jpg 1x, /sites/default/files/styles/feature_banner_medium_2x/public/2024-11/charles-chiu-dna-extraction.jpg 2x" media="all and (min-width: 850px) and (max-width: 1049px)" type="image/jpeg" width="1050" height="569"/> <source srcset="/sites/default/files/styles/feature_banner_narrow/public/2024-11/charles-chiu-dna-extraction.jpg 1x, /sites/default/files/styles/feature_banner_narrow_2x/public/2024-11/charles-chiu-dna-extraction.jpg 2x" media="all and (min-width: 769px) and (max-width: 849px)" type="image/jpeg" width="850" height="460"/> <source srcset="/sites/default/files/styles/feature_banner_small/public/2024-11/charles-chiu-dna-extraction.jpg 1x, /sites/default/files/styles/feature_banner_small_2x/public/2024-11/charles-chiu-dna-extraction.jpg 2x" media="all and (max-width: 768px)" type="image/jpeg" width="769" height="417"/> <source srcset="/sites/default/files/styles/featur_banner_x_small/public/2024-11/charles-chiu-dna-extraction.jpg 1x, /sites/default/files/styles/featur_banner_x_small_2x/public/2024-11/charles-chiu-dna-extraction.jpg 2x" media="all and (max-width: 599px)" type="image/jpeg" width="600" height="325"/> <img loading="eager" src="/sites/default/files/styles/article_feature_banner__image/public/2024-11/charles-chiu-dna-extraction.jpg" width="1440" height="780" alt="Researcher Charles Chiu is pictured in the reflection of a robotic machine used to extract DNA from a sample." class="element-fade"/> </picture> </figure> <div class="article-feature-overlay"> </div> </figure> <header class="article-header article-feature-overlay-header"> <ul class="article-header__byline"> <li class="article-header__primary-area" data-primary-area="pa-research">Research</li> <li class="article-header__date"> <div class="field field-date-and-time field--type-datetime field--label-hidden field__item"><time datetime="2024-11-13T01:28:53Z" class="datetime"> November 12, 2024 </time> </div> </li> </ul> <h1><span class="field field--name-title field--type-string field--label-hidden">1 Genomic Test Can Diagnose Nearly Any Infection</span> </h1> <h2 class="field field-sub-title field--type-text field--label-hidden article-header__subheading">Next-generation metagenomic sequencing test developed at UCSF proves its effectiveness in quickly diagnosing almost any kind of pathogen.</h2> <p class="article-header__author"> By <a href="https://www.ucsf.edu/bio/levi-gadye">Levi Gadye</a> <span class="article-art-credit">UCSF infectious diseases physician and microbiologist Charles Chiu, MD, PhD, watches as a robot extracts DNA from a sample. Photo by Noah Berger</span> </p> </header> </div> <div class="main-content article-feature-content narrow-page"> <ul class="article-meta-share"> <li><a rel="nofollow" href="https://www.facebook.com/share.php?u=https://www.ucsf.edu/news/2024/11/428831/1-genomic-test-can-diagnose-nearly-any-infection" target="_blank" title="Share on Facebook"><span class="fab fa-facebook-square"></span> <span class="indent-text">Share on Facebook</span></a></li> <li><a rel="nofollow" href="https://www.twitter.com/share?text=1 Genomic Test Can Diagnose Nearly Any Infection&url=https://www.ucsf.edu/news/2024/11/428831/1-genomic-test-can-diagnose-nearly-any-infection" target="_blank" title="Share on Twitter"><span class="fa-brands fa-square-x-twitter"></span> <span class="indent-text">Share on Twitter</span></a></li> <li><a rel="nofollow" href="https://www.reddit.com/submit?url=https://www.ucsf.edu/news/2024/11/428831/1-genomic-test-can-diagnose-nearly-any-infection&title=1 Genomic Test Can Diagnose Nearly Any Infection" target="_blank" title="Share on Reddit"><span class="fab fa-reddit-square"></span> <span class="indent-text">Share on Reddit</span></a></li> <li><a rel="nofollow" href="/cdn-cgi/l/email-protection#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" title="Email this article"><span class="fas fa-envelope-square"></span> <span class="indent-text">Email this article</span></a></li> <li><a rel="nofollow" onclick="window.print();return false;" href="https://www.ucsf.edu/news/2024/11/428831/1-genomic-test-can-diagnose-nearly-any-infection" title="Print this article"><span class="fas fa-print"></span> <span class="indent-text">Print this article</span></a></li> </ul> <div class="page_narrow"><p class="drop-cap">A genomic test developed at UC San Francisco to rapidly detect almost any kind of pathogen – virus, bacteria, fungus or parasite – has proved successful after a decade of use.</p> <p>The test has the potential to vastly improve care for neurological infections that cause diseases like meningitis and encephalitis, as well as speed up the detection of new viral pandemic threats. It uses a powerful genomic sequencing technique, called metagenomic next-generation sequencing (mNGS).</p> <p>Rather than looking for one type of pathogen at a time, mNGS analyzes all the nucleic acids, RNA and DNA, that are present in a sample.</p> <aside class="ucsfcallout callout-right" data-image="1"> <div class="callout__image"> <div> <figure data-embed-button="media_assets" data-entity-embed-display="entity_reference:media_thumbnail" data-entity-embed-display-settings="{"image_style":"","image_link":"","image_loading":{"attribute":"lazy"},"link_title":"","link_url":"","target":0}" data-entity-type="media" data-entity-uuid="3bcdcd0a-ae91-421b-9bd6-1f6b8355adbd" data-langcode="en" class="embedded-entity"><picture> <img loading="lazy" src="/sites/default/files/2024-11/charles-chiu-square.jpg" width="800" height="800" alt="A headshot of Charles Chiu." class="element-fade"> </picture></figure> </div> </div> <div class="callout__content"> <p class="quote-style">“Our goal was to have the entire process completed within 12 to 24 hours, giving a same-day or next-day result.”</p> <p class="eyebrow-title">Charles Chiu, MD, PhD</p> </div> </aside> <p>“Our technology is deceptively simple,” said <a href="https://profiles.ucsf.edu/charles.chiu">Charles Chiu</a>, MD, PhD, professor of laboratory medicine and infectious diseases at UCSF and senior author of the study. “By replacing multiple tests with a single test, we can take the lengthy guesswork out of diagnosing and treating infections.”</p> <p>The researchers originally developed a clinical mNGS test to analyze cerebrospinal fluid (CSF), the pristine liquid that bathes the brain and spinal cord.</p> <p>The test has now been performed on thousands of patients with unexplained neurological symptoms, both at UCSF and other hospitals across the country.</p> <p>In a paper that appears Nov. 12 in <em><a href="https://www.nature.com/articles/s41591-024-03275-1">Nature Medicine</a></em>, the team demonstrated that the mNGS test correctly identified 86% of neurological infections.</p> <p>In a companion study published the same day in <em><a href="https://www.nature.com/articles/41467-024-51470-y">Nature Communications</a></em>, the team also used mNGS to identify pathogens in respiratory fluid that can cause pneumonia, and automated it to get results faster.</p> <p>They expect that the automated test will be able to detect novel viral pathogens that could cause respiratory pandemics like COVID-19.</p> </div> <div class="layout-columns__4" style="background-color:#9BA6B6"> <div class="layout__heading-description"><h3><strong>The types of infections that can threaten our brains and lungs</strong></h3> <p class="null">Different types of pathogens – bacterial, fungal, parasitic or viral – can invade our bodies and cause life-threatening diseases, especially when they can’t be quickly diagnosed and properly treated. The mNGS test developed at UCSF correctly identified 86% of neurological infections, some of which are caused by the types of pathogens below.</p> </div> <div class="field field-content-wrapper-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="layout-column"> <div class="paragraph paragraph--type--column-content paragraph--view-mode--default"> <div class="field field-column-content-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph-text-block"> <figure data-embed-button="media_assets" data-entity-embed-display="entity_reference:media_thumbnail" data-entity-embed-display-settings="{"image_style":"","image_link":"","image_loading":{"attribute":"lazy"},"link_title":"","link_url":"","target":0}" data-entity-type="media" data-entity-uuid="c787cbe4-8d4d-4d5c-83d8-cece400c2ca0" data-langcode="en" style="border: 1px solid #052049;" class="embedded-entity"><picture> <img loading="lazy" src="/sites/default/files/2024-11/bacterium-nocardia-square.jpg" width="800" height="800" alt="A microscopic image of the bacteria nocardia, which resembles thin, orange branches." class="element-fade"> </picture></figure> <h3 class="eyebrow-title">Bacterial</h3> <p class="small-text">Bacteria like Nocardia, as seen above, can cause pneumonia or encephalitis. <em>Image by Chiu Lab</em></p> </div> </div> </div> </div> </div> <div class="layout-column"> <div class="paragraph paragraph--type--column-content paragraph--view-mode--default"> <div class="field field-column-content-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph-text-block"> <figure data-embed-button="media_assets" data-entity-embed-display="entity_reference:media_thumbnail" data-entity-embed-display-settings="{"image_style":"","image_link":"","image_loading":{"attribute":"lazy"},"link_title":"","link_url":"","target":0}" data-entity-type="media" data-entity-uuid="d31eca49-3e6d-4e3a-adcd-266f0a919a3f" data-langcode="en" style="border: 1px solid #052049;" class="embedded-entity"><picture> <img loading="lazy" src="/sites/default/files/2024-11/fungal-rhizopus-square.jpg" width="800" height="800" alt="A microscopic image of the fungus Rhizopus, which are long strands with cirucular glands at the end." class="element-fade"> </picture></figure> <h3 class="eyebrow-title">Fungal</h3> <p class="small-text">Fungi such as Rhizopus, pictured above, can infect cerebrospinal fluid and respiratory fluid. <em>Image by Chiu Lab</em></p> </div> </div> </div> </div> </div> <div class="layout-column"> <div class="paragraph paragraph--type--column-content paragraph--view-mode--default"> <div class="field field-column-content-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph-text-block"> <figure data-embed-button="media_assets" data-entity-embed-display="entity_reference:media_thumbnail" data-entity-embed-display-settings="{"image_style":"","image_link":"","image_loading":{"attribute":"lazy"},"link_title":"","link_url":"","target":0}" data-entity-type="media" data-entity-uuid="49d612da-5477-47b8-9f28-ec7005270dea" data-langcode="en" style="border: 1px solid #052049;" class="embedded-entity"><picture> <img loading="lazy" src="/sites/default/files/2024-11/parasitic-acanthamoeba-square.jpg" width="800" height="800" alt="A microscopic image of parasitic acanthamoeba that has carved a hole in the brain." class="element-fade"> </picture></figure> <h3 class="eyebrow-title">Parasitic</h3> <p class="small-text">Here, Acanthamoeba parasites, known as the “brain eating amoeba”, carved a hole in the brain and are also ingesting red blood cells. <em>Image by Chiu Lab</em></p> </div> </div> </div> </div> </div> <div class="layout-column"> <div class="paragraph paragraph--type--column-content paragraph--view-mode--default"> <div class="field field-column-content-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph-text-block"> <figure data-embed-button="media_assets" data-entity-embed-display="entity_reference:media_thumbnail" data-entity-embed-display-settings="{"image_style":"","image_link":"","image_loading":{"attribute":"lazy"},"link_title":"","link_url":"","target":0}" data-entity-type="media" data-entity-uuid="3d6af641-9d81-481a-b0a4-3dd5bd4fe37e" data-langcode="en" style="border: 1px solid #052049;" class="embedded-entity"><picture> <img loading="lazy" src="/sites/default/files/2024-11/virus-adenovirus-square.jpg" width="800" height="800" alt="A microscopic image of adenoviruses, which are small purple particles." class="element-fade"> </picture></figure> <h3 class="eyebrow-title">Viral</h3> <p class="small-text">Adenoviruses in cerebrospinal fluid and respiratory fluid can cause diseases like bronchitis or pneumonia. <em>Image by Centers for Disease Control</em></p> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph-text-block paragraph-responsive-areas"> <div class="clearfix text-formatted field field-desktop-area field--type-text-long field--label-hidden field__item"><h2><br> A breakthrough in diagnosing rare, infectious neurological disease</h2> <p>Neurological diseases can be very hard to diagnose, especially when the cause is a rare or previously unknown pathogen. In many cases, each day without a diagnosis means a continual worsening of a patient’s condition.</p> <p>In the early 2010s, Chiu, along with UCSF colleagues <a href="https://profiles.ucsf.edu/joe.derisi">Joe DeRisi</a>, PhD, and <a href="https://profiles.ucsf.edu/michael.r.wilson">Michael Wilson</a>, MD, developed a novel metagenomic sequencing method to test CSF for potential pathogens causing neurologic infections.</p> <p>The test works by sequencing all the genetic material in CSF, then running a computational analysis pipeline to separate human sequences from those that originate from bacteria, viruses, fungi or parasites.</p> <p>In 2014, the team used the technology to help doctors in Wisconsin <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="cc0d5afb-f459-42dc-97f3-79979d86098e" href="https://www.ucsf.edu/news/2014/06/115116/diagnosis-just-time" title="A Diagnosis Just in Time">treat a young boy</a> who was critically ill in the intensive care unit with an undiagnosed infection.</p> <p>A long series of tests had failed to find out what was wrong with him, but UCSF’s test took just 48 hours to reveal that the boy had leptospirosis, which is treatable with penicillin. His doctors gave it to him, and he fully recovered.</p> <blockquote class="blockquote blockquote--half-left"> <p class="blockquote-content__text">Our mNGS test performs better than any other category of test for neurologic infections.”</p> <footer> <p class="blockquote-content__cite">Charles Chiu, MD, PhD</p> </footer> </blockquote> <p>The mNGS test soon became routine at UCSF, with hospitals and clinics nationwide sending samples to be processed by the UCSF Clinical Microbiology Laboratory, of which Chiu is the director.</p> <p>Between 2016 and 2023, the UCSF team analyzed nearly 5,000 CSF samples with the test, 14.4% of which turned out to have an infection. In those samples, the test accurately identified the pathogen 86% of the time.</p> <p>“Our mNGS test performs better than any other category of test for neurologic infections,” Chiu said, “The results support its use as a critical part of the diagnostic armamentarium for physicians who are working up patients with infectious diseases.”</p> <p>To increase access to this technology, Chiu, DeRisi, Wilson and others helped found Delve Bio, which is now the exclusive provider of the mNGS CSF test developed at UCSF.</p> <p>“These findings support including mNGS as a core tool in the clinical workup for CNS infections,” said Steve Miller, MD, PhD, chief medical officer of Delve Bio. “mNGS offers the single most unbiased, complete and definitive tool for pathogen detection. Thanks to its ability to quickly diagnose an infection, mNGS helps guide management decisions and treatment for patients with meningitis and encephalitis, potentially reducing healthcare costs down the line.”</p> <h2>Preparing for the next pandemic</h2> <p>If it is going to serve as an early-warning system for pandemics, the mNGS test must be fast. Chiu and his colleagues have adapted it to work with respiratory fluid and figured out how to automate it.</p> <p>Whereas the CSF test entails more than 100 separate steps and can take 2 to 7 days to process, the respiratory test requires just 30 minutes of hands-on time before robots and algorithms can take over.</p> <p>“Our goal was to have the entire process completed within 12 to 24 hours, giving a same-day or next-day result,” Chiu said.</p> <p>In the Nature Communications study, the researchers demonstrated that the test could detect respiratory viruses with pandemic potential, including SARS-CoV-2, influenza A and B, and RSV in less than a day, even when there were only small amounts of virus present in a sample.</p> <p>They also modeled the technology’s ability to detect divergent viruses – or newly-evolved strains – and found that it could hypothetically detect all of them, should they emerge in the future.</p> <p>Both the CSF and respiratory versions of the mNGS test have received breakthrough device designation from the U.S. Food and Drug Administration (FDA).</p> <figure class="caption caption-drupal-entity"> <figure data-embed-button="media_assets" data-entity-embed-display="entity_reference:media_thumbnail" data-entity-embed-display-settings="{"image_style":"","image_link":"","image_loading":{"attribute":"lazy"},"link_title":"","link_url":"","target":0}" data-entity-type="media" data-entity-uuid="01173127-1803-4454-88dd-7c7ccb2448a2" data-langcode="en" class="embedded-entity"><picture> <img loading="lazy" src="/sites/default/files/2024-11/charles-chiu-jenna-chiu.jpg" width="1800" height="1200" alt="Charles Chiu and Jenna Chiu wear protective lab gear as Jenna pipes DNA samples into a machine." class="element-fade"> </picture></figure> <figcaption>Clinical research coordinator Jenna Chui loads DNA samples into a biorobot as Charles Chiu, MD, PHD, looks on. <em>Photo by Noah Berger</em></figcaption> </figure> <p class="small-text"><strong>Authors:</strong> For the <em>Nature Medicine</em> paper, other UCSF authors are Patrick Benoit, MD, Noah Brazer, Mikael de Lorenzi-Tognon, MD, PhD, Emily Kelly, MD, MS, Venice Servellita, MS, Miriam Oseguera, Jenny Nguyen, MD, MA, Jack Tang, MHS, Charles Omura, Jessica Streithorst, PhD, Melissa Hillberg, Danielle Ingebrigtsen, MHS, Kelsey Zorn, MHS, and Michael R. Wilson, MD. For all authors, see the paper.</p> <p class="small-text">For the <em>Nature Communications</em> paper, other UCSF authors are Jessica Karielle Tan, PhD, Venice Servellita, MS, Doug Stryke, Emily Kelly, MD, MS, Jessica Streithorst, PhD, Nanami Sumimoto, Abiodun Foresythe, Hee Jae Huh, Jenny Nguyen MD, MA, Miriam Oseguera, Noah Brazer, Jack Tang, MHS, Danielle Ingebrigtsen, MHS, Becky Fung, Helen Reyes, Melissa Hillberg, Peter M. Mourani, Charles R. Langelier, MD, PhD, Mikael de Lorenzi-Tognon, MD, PhD, and Patrick Benoit, MD. For all authors, see the paper.</p> <p class="small-text"><strong>Funding:</strong> The <em>Nature Medicine</em> paper was supported in part by a BARDA EZ-BAA award 75A50122C00022, US CDC grants 75D30122C15360 and 75D30121C12641 and the Chan Zuckerberg Biohub San Francisco.</p> <p class="small-text">The <em>Nature Communications</em> paper was supported in part by in part by a BARDA EZ-BAA 494 award 75A50122C00022, US CDC grants 75D30122C15360 and 75D30121C12641, Abbott Laboratories and the Chan Zuckerberg Biohub San Francisco.</p> <p class="small-text"><strong>Disclosures:</strong> Chiu is a founder of Delve Bio and serves on its scientific advisory board, as well as those of Flightpath Biosciences, Biomeme, Mammoth Biosciences, BiomeSense and Poppy Health. He is also an inventor on US patent 509 11380421, “Pathogen detection using next generation sequencing.” Wilson is a co-founder and serves on the scientific advisory board and board of directors for Delve Bio.</p> </div> <div class="clearfix text-formatted field field-mobile-area field--type-text-long field--label-hidden field__item"><h2><br> A breakthrough in diagnosing rare, infectious neurological disease</h2> <p>Neurological diseases can be very hard to diagnose, especially when the cause is a rare or previously unknown pathogen. In many cases, each day without a diagnosis means a continual worsening of a patient’s condition.</p> <p>In the early 2010s, Chiu, along with UCSF colleagues <a href="https://profiles.ucsf.edu/joe.derisi">Joe DeRisi</a>, PhD, and <a href="https://profiles.ucsf.edu/michael.r.wilson">Michael Wilson</a>, MD, developed a novel metagenomic sequencing method to test CSF for potential pathogens causing neurologic infections.</p> <p>The test works by sequencing all the genetic material in CSF, then running a computational analysis pipeline to separate human sequences from those that originate from bacteria, viruses, fungi or parasites.</p> <p>In 2014, the team used the technology to help doctors in Wisconsin <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="cc0d5afb-f459-42dc-97f3-79979d86098e" href="https://www.ucsf.edu/news/2014/06/115116/diagnosis-just-time" title="A Diagnosis Just in Time">treat a young boy</a> who was critically ill in the intensive care unit with an undiagnosed infection.</p> <p>A long series of tests had failed to find out what was wrong with him, but UCSF’s test took just 48 hours to reveal that the boy had leptospirosis, which is treatable with penicillin. His doctors gave it to him, and he fully recovered.</p> <blockquote class="blockquote blockquote--half-left"> <p class="blockquote-content__text">Our mNGS test performs better than any other category of test for neurologic infections.”</p> <footer> <p class="blockquote-content__cite">Charles Chiu, MD, PhD</p> </footer> </blockquote> <p>The mNGS test soon became routine at UCSF, with hospitals and clinics nationwide sending samples to be processed by the UCSF Clinical Microbiology Laboratory, of which Chiu is the director.</p> <p>Between 2016 and 2023, the UCSF team analyzed nearly 5,000 CSF samples with the test, 14.4% of which turned out to have an infection. In those samples, the test accurately identified the pathogen 86% of the time.</p> <p>“Our mNGS test performs better than any other category of test for neurologic infections,” Chiu said, “The results support its use as a critical part of the diagnostic armamentarium for physicians who are working up patients with infectious diseases.”</p> <p>To increase access to this technology, Chiu, DeRisi, Wilson and others helped found Delve Bio, which is now the exclusive provider of the mNGS CSF test developed at UCSF.</p> <p>“These findings support including mNGS as a core tool in the clinical workup for CNS infections,” said Steve Miller, MD, PhD, chief medical officer of Delve Bio. “mNGS offers the single most unbiased, complete and definitive tool for pathogen detection. Thanks to its ability to quickly diagnose an infection, mNGS helps guide management decisions and treatment for patients with meningitis and encephalitis, potentially reducing healthcare costs down the line.”</p> <h2>Preparing for the next pandemic</h2> <p>If it is going to serve as an early-warning system for pandemics, the mNGS test must be fast. Chiu and his colleagues have adapted it to work with respiratory fluid and figured out how to automate it.</p> <figure class="caption caption-drupal-entity full-bleed-image"> <figure data-embed-button="media_assets" data-entity-embed-display="entity_reference:media_thumbnail" data-entity-embed-display-settings="{"image_style":"full_bleed__image","image_link":"","image_loading":{"attribute":"lazy"},"link_title":"","link_url":"","target":0}" data-entity-type="media" data-entity-uuid="01173127-1803-4454-88dd-7c7ccb2448a2" data-langcode="en" class="embedded-entity"><picture> <img loading="lazy" src="/sites/default/files/styles/full_bleed__image/public/2024-11/charles-chiu-jenna-chiu.jpg" width="1280" height="853" alt="Charles Chiu and Jenna Chiu wear protective lab gear as Jenna pipes DNA samples into a machine." class="element-fade"> </picture></figure> <figcaption>Clinical research coordinator Jenna Chui loads DNA samples into a biorobot as Charles Chiu, MD, PHD, looks on. <em>Photo by Noah Berger</em></figcaption> </figure> <p>Whereas the CSF test entails more than 100 separate steps and can take 2 to 7 days to process, the respiratory test requires just 30 minutes of hands-on time before robots and algorithms can take over.</p> <p>“Our goal was to have the entire process completed within 12 to 24 hours, giving a same-day or next-day result,” Chiu said.</p> <p>In the Nature Communications study, the researchers demonstrated that the test could detect respiratory viruses with pandemic potential, including SARS-CoV-2, influenza A and B, and RSV in less than a day, even when there were only small amounts of virus present in a sample.</p> <p>They also modeled the technology’s ability to detect divergent viruses – or newly-evolved strains – and found that it could hypothetically detect all of them, should they emerge in the future.</p> <p>Both the CSF and respiratory versions of the mNGS test have received breakthrough device designation from the U.S. Food and Drug Administration (FDA).</p> <p class="small-text"><strong>Authors:</strong> For the <em>Nature Medicine</em> paper, other UCSF authors are Patrick Benoit, MD, Noah Brazer, Mikael de Lorenzi-Tognon, MD, PhD, Emily Kelly, MD, MS, Venice Servellita, MS, Miriam Oseguera, Jenny Nguyen, MD, MA, Jack Tang, MHS, Charles Omura, Jessica Streithorst, PhD, Melissa Hillberg, Danielle Ingebrigtsen, MHS, Kelsey Zorn, MHS, and Michael R. Wilson, MD. For all authors, see the paper.</p> <p class="small-text">For the <em>Nature Communications</em> paper, other UCSF authors are Jessica Karielle Tan, PhD, Venice Servellita, MS, Doug Stryke, Emily Kelly, MD, MS, Jessica Streithorst, PhD, Nanami Sumimoto, Abiodun Foresythe, Hee Jae Huh, Jenny Nguyen MD, MA, Miriam Oseguera, Noah Brazer, Jack Tang, MHS, Danielle Ingebrigtsen, MHS, Becky Fung, Helen Reyes, Melissa Hillberg, Peter M. Mourani, Charles R. Langelier, MD, PhD, Mikael de Lorenzi-Tognon, MD, PhD, and Patrick Benoit, MD. For all authors, see the paper.</p> <p class="small-text"><strong>Funding:</strong> The <em>Nature Medicine</em> paper was supported in part by a BARDA EZ-BAA award 75A50122C00022, US CDC grants 75D30122C15360 and 75D30121C12641 and the Chan Zuckerberg Biohub San Francisco.</p> <p class="small-text">The <em>Nature Communications</em> paper was supported in part by in part by a BARDA EZ-BAA 494 award 75A50122C00022, US CDC grants 75D30122C15360 and 75D30121C12641, Abbott Laboratories and the Chan Zuckerberg Biohub San Francisco.</p> <p class="small-text"><strong>Disclosures:</strong> Chiu is a founder of Delve Bio and serves on its scientific advisory board, as well as those of Flightpath Biosciences, Biomeme, Mammoth Biosciences, BiomeSense and Poppy Health. He is also an inventor on US patent 509 11380421, “Pathogen detection using next generation sequencing.” Wilson is a co-founder and serves on the scientific advisory board and board of directors for Delve Bio.</p> </div> </div> <div class="tags-menu-region"> <h3 class="tags-menu__title">Topics</h3> <ul class="tags-menu"> <li class="tags-menu__item"><a href="/topics/genetics-and-genomics" hreflang="en">Genetics and Genomics</a></li> <li class="tags-menu__item"><a href="/topics/infectious-disease" hreflang="en">Infectious Disease</a></li> <li class="tags-menu__item"><a href="/topics/neurology" hreflang="en">Neurology</a></li> <li class="tags-menu__item"><a href="/topics/technology-and-ai" hreflang="en">Technology and AI</a></li> </ul> </div> </div> </main> <aside class="recommended-articles "> <div class="recommended-articles__banner"> <h2 class="recommended-articles__title">Recommended Reading</h2> </div> <div class="views-element-container"><div class="element-swoosh view view-articles-by-term view-id-articles_by_term view-display-id-block_1 js-view-dom-id-2cd4ecd452cf01117c589058b3250cca73d3cb9d335dc2a36c449c84572b4cea"> <div class="view-content"> <div class="views-row"> <article data-history-node-id="428926" class="news-card" data-primary-area="pa-campus-news"> <a href="https://www.ucsf.edu/news/2024/11/428926/chancellor-celebrates-ucsfs-momentum-2024-state-university-address" class="news-card__link"> <figure> <picture class="field field-card-image field--type-entity-reference field--label-hidden field__item"> <source srcset="/sites/default/files/styles/news_card__image/public/2024-11/State%20of%20the%20University%202024.png 1x, /sites/default/files/styles/news_card__image/public/2024-11/State%20of%20the%20University%202024.png 2x" media="all and (max-width: 599px)" type="image/png" width="600" height="338"/> <img loading="lazy" src="/sites/default/files/styles/news_card__image/public/2024-11/State%20of%20the%20University%202024.png" width="600" height="338" alt="Chancellor speaks gesturing with his hands." class="element-fade"/> </picture> </figure> <header class="news-card__copy"> <ul class="article-header__byline"> <li class="article-header__primary-area" data-primary-area="pa-campus-news">Campus News</li> <li class="article-header__date"> <div class="field field-date-and-time field--type-datetime field--label-hidden field__item"><time datetime="2024-11-22T18:00:00Z" class="datetime"> Nov. 22, 2024 </time> </div> </li> </ul> <h2><span class="field field--name-title field--type-string field--label-hidden">Chancellor Celebrates UCSF’s ‘Momentum’ in 2024 State of the University Address </span> </h2> </header> </a> </article> </div> <div class="views-row"> <article data-history-node-id="428896" class="news-card" data-primary-area="pa-research"> <a href="https://www.ucsf.edu/news/2024/11/428896/how-optogenetics-can-put-brakes-epilepsy-seizures" class="news-card__link"> <figure> <picture class="field field-card-image field--type-entity-reference field--label-hidden field__item"> <source srcset="/sites/default/files/styles/news_card__image/public/2024-11/brain-slice-microscopy_0.jpg 1x, /sites/default/files/styles/news_card__image/public/2024-11/brain-slice-microscopy_0.jpg 2x" media="all and (max-width: 599px)" type="image/jpeg" width="600" height="338"/> <img loading="lazy" src="/sites/default/files/styles/news_card__image/public/2024-11/brain-slice-microscopy_0.jpg" width="600" height="338" alt="A microscopic close-up of brain tissue, dyed purple and blue." class="element-fade"/> </picture> </figure> <header class="news-card__copy"> <ul class="article-header__byline"> <li class="article-header__primary-area" data-primary-area="pa-research">Research</li> <li class="article-header__date"> <div class="field field-date-and-time field--type-datetime field--label-hidden field__item"><time datetime="2024-11-15T17:16:12Z" class="datetime"> Nov. 15, 2024 </time> </div> </li> </ul> <h2><span class="field field--name-title field--type-string field--label-hidden">How Optogenetics Can Put the Brakes on Epilepsy Seizures</span> </h2> </header> </a> </article> </div> <div class="views-row"> <article data-history-node-id="428876" class="news-card" data-primary-area="pa-research"> <a href="https://www.ucsf.edu/news/2024/11/428876/ai-tool-helps-neurosurgeons-find-sneaky-cancer-cells" class="news-card__link"> <figure> <picture class="field field-card-image field--type-entity-reference field--label-hidden field__item"> <source srcset="/sites/default/files/styles/news_card__image/public/2024-11/shawn-hervey-jumper-surgery.jpg 1x, /sites/default/files/styles/news_card__image/public/2024-11/shawn-hervey-jumper-surgery.jpg 2x" media="all and (max-width: 599px)" type="image/jpeg" width="600" height="338"/> <img loading="lazy" src="/sites/default/files/styles/news_card__image/public/2024-11/shawn-hervey-jumper-surgery.jpg" width="600" height="338" alt="Neuroseurgon Shawn Hervey-Jumper wears surgical scrubs and a mask, along with surgical loupes, while he performs neurosurgery." class="element-fade"/> </picture> </figure> <header class="news-card__copy"> <ul class="article-header__byline"> <li class="article-header__primary-area" data-primary-area="pa-research">Research</li> <li class="article-header__date"> <div class="field field-date-and-time field--type-datetime field--label-hidden field__item"><time datetime="2024-11-13T18:57:03Z" class="datetime"> Nov. 13, 2024 </time> </div> </li> </ul> <h2><span class="field field--name-title field--type-string field--label-hidden">This AI Tool Helps Neurosurgeons Find Sneaky Cancer Cells</span> </h2> </header> </a> </article> </div> </div> </div> </div> <div class="footer-ctas-wrapper"> <div class="field field-ankle-cta field--type-entity-reference field--label-hidden field__items"> <div class="field__item"> <div class="clearfix text-formatted field body field--type-text-with-summary field--label-hidden field__item"><h2>Stay in touch with the latest updates.</h2> <p><a class="icon-media" data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="cab6a11f-4158-4d04-88f1-d511d9455ca2" href="https://www.ucsf.edu/subscribe-ucsf-news" title="Subscribe to UCSF News">Subscribe to UCSF News</a></p> </div> </div> <div class="field__item"> <div class="clearfix text-formatted field body field--type-text-with-summary field--label-hidden field__item"><h2>Are you a member of the news media?</h2> <p><a class="icon-media" data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="389ec7dc-e40f-4077-9e9c-884ccbea0dec" href="https://www.ucsf.edu/news-media/journalists" title="Resources for Journalists">Visit the Media Center</a></p> </div> </div> </div> </div> </aside> </div> </div> <footer class="footer-region"> <div class="footer"> <div class="logo-follow"> <figure class="footer-logo"> <a class="footer-logo__link" href="/"> <div class="footer-logo__image"> <img class="footer-logo__img" src="/themes/custom/ucsf/images/footer-logo.svg" alt="UCSF Footer Logo" width="100" height="100"> </div> </a> </figure> <div class="follow"> <h2>Follow Us:</h2> <ul> <li class="follow-facebook"><a href="https://www.facebook.com/ucsf"><span class="fab fa-facebook-f"></span> <span class="indent-text">Facebook</span></a></li> <li class="follow-twitter"><a href="https://www.twitter.com/ucsf"><span class="fab fa-x-twitter"></span> <span class="indent-text">Twitter</span></a></li> <li class="follow-youtube"><a href="https://www.youtube.com/ucsf"><span class="fab fa-youtube"></span> <span class="indent-text">YouTube</span></a></li> <li class="follow-instagram"><a href="https://www.instagram.com/ucsf"><span class="fab fa-instagram"></span> <span class="indent-text">Instagram</span></a></li> </ul> </div> </div> <nav aria-label="Main" id="block-ucsf-footer" class="block block-menu navigation menu--footer"> <ul block="block-ucsf-footer" class="menu"> <li class="menu-item" > <a href="https://www.ucsf.edu/cgr/advocacy" data-drupal-link-system-path="node/408041">Become a UCSF Advocate</a> </li> <li class="menu-item" > <a href="https://ucsfhealth.samaritan.com">Volunteer at UCSF Medical Center</a> </li> <li class="menu-item" > <a href="https://together.ucsf.edu/">Start a Fundraiser</a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/subscribe-ucsf-news" data-drupal-link-system-path="node/403161">Subscribe to UCSF News</a> </li> </ul> </nav> <nav aria-label="Main" id="block-footer2resources" class="block block-menu navigation menu--footer2"> <ul block="block-footer2resources" class="menu"> <li class="menu-item" > <a href="https://websites.ucsf.edu/azlist">A to Z Website List</a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/accessibility-resources" data-drupal-link-system-path="node/421786">Accessibility Resources</a> </li> <li class="menu-item" > <a href="https://policies.ucsf.edu/">Administrative Policies</a> </li> <li class="menu-item" > <a href="https://identity.ucsf.edu/">Brand Guidelines</a> </li> <li class="menu-item" > <a href="https://campuslifeserviceshome.ucsf.edu/">Campus Life Services</a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/about/locations" data-drupal-link-system-path="node/96416">Campus Maps</a> </li> <li class="menu-item" > <a href="https://www.ucsf.edu/about/working-ucsf" data-drupal-link-system-path="node/409191">Careers at UCSF</a> </li> <li class="menu-item" > <a href="https://chancellor.ucsf.edu/">Chancellor</a> </li> <li class="menu-item" > <a href="https://diversity.ucsf.edu/">Diversity & Outreach</a> </li> <li class="menu-item" > <a href="https://police.ucsf.edu/emergency-preparedness">Emergency Preparedness</a> </li> <li class="menu-item" > <a href="https://hr.ucsf.edu">Human Resources</a> </li> <li class="menu-item" > <a href="https://www.library.ucsf.edu/">Library</a> </li> <li class="menu-item" > <a href="https://directory.ucsf.edu/">People Directory</a> </li> <li class="menu-item" > <a href="https://police.ucsf.edu/">Police</a> </li> <li class="menu-item" > <a href="https://campuslifeservices.ucsf.edu/transportation/services/shuttles/">Shuttle Schedule</a> </li> <li class="menu-item" > <a href="https://profiles.ucsf.edu">UCSF Profiles</a> </li> </ul> </nav> <div id="block-popwiseblock" class="block block-block-content block-block-content6efc2b33-6a3d-487d-8945-4c884ad0df82"> <div class="clearfix text-formatted field body field--type-text-with-summary field--label-hidden field__item"><script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="text/javascript" data-cfasync="false"> (function(W,i,s,e,P,o,p){W['WisePopsObject']=P;W[P]=W[P]||function(){ (W[P].q=W[P].q||[]).push(arguments)},W[P].l=1*new Date();o=i.createElement(s), p=i.getElementsByTagName(s)[0];o.async=1;o.src=e;p.parentNode.insertBefore(o,p) })(window,document,'script','//loader.wisepops.com/get-loader.js?v=1&site=dQ5haeqNrm','wisepops'); </script></div> </div> </div> <div class="footer-bottom"> <p>© 2024 The Regents of The University of California</p> <ul class="text-align: right;"> <li><a href="/sitemap.xml" style="left: -9999px; position:absolute;" tabindex="-1" aria-hidden="true">Sitemap</a></li> <li><a href="/sitemap">Site Map</a></li> <li><a href="/terms-of-use">Terms of Use</a></li> <li><a href="/feedback">Report an issue with UCSF.edu website</a></li> </ul> </div> </footer> </div> </div> <script>window.dataLayer = window.dataLayer || []; window.dataLayer.push({"drupalLanguage":"en","drupalCountry":"US","siteName":"UC San Francisco","entityCreated":"1730856533","entityLangcode":"en","entityStatus":"1","entityUid":"11011","entityUuid":"78e66604-b7e3-42ac-918d-4d9145c44d90","entityVid":"776956","entityName":"kquintanilla","entityType":"node","entityBundle":"article","entityId":"428831","entityTitle":"1 Genomic Test Can Diagnose Nearly Any Infection","entityTaxonomy":{"areas":{"726":"Research"},"article_type":{"714":"Press Release"},"topics":{"413431":"Genetics and Genomics","654":"Infectious Disease","668":"Neurology","1096":"Technology and AI"}},"userUid":0});</script>  <link name="polymer_platform" href="/modules/custom/ckeditor_y3ti_plugins/elements/build.html" rel="import" /> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/428831","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxlkNFyAyEIRX_Irg_9IIdVskuD4ggmtV9fm02bpn1hmIPeeyGeMZFJC-PVKFTuGxX1V1yj5CoFi6mLDKrDr6D43WdUhQ3nTBr6Ii0D0we6BAYMA5tfcYcLSVN3IrYJIlQjKa5Cg61B3dWn1ivw8iBLL7WvTLpjciqRgEOeASEwlbP6_2ixHTM6NTBSo_gj-iBOhxrmI3-PevLI80-xcIL0h8gFG0MNCQ3jLe7TWK8iuh9sY1mBj_6rBGjTjTGY1Oka5mXa1Ag7QqKy_Xp434KiFL3jQtNYgRWhxcMgQJIVAxTgcVvsAd2F8Kr-Vhd4g_cnkCV1RjekW58CGzBjG_e8L2pjHm77BBnlxuc","theme":"ucsf","theme_token":null},"ajaxTrustedUrl":[],"dataLayer":{"defaultLang":"en","languages":{"en":{"id":"en","name":"English","direction":"ltr","weight":0}}},"statistics":{"data":{"nid":"428831"},"url":"\/core\/modules\/statistics\/statistics.php"},"views":{"ajax_path":"\/views\/ajax","ajaxViews":{"views_dom_id:2cd4ecd452cf01117c589058b3250cca73d3cb9d335dc2a36c449c84572b4cea":{"view_name":"articles_by_term","view_display_id":"block_1","view_args":"413431+654+668+1096\/428831","view_path":"\/node\/428831","view_base_path":null,"view_dom_id":"2cd4ecd452cf01117c589058b3250cca73d3cb9d335dc2a36c449c84572b4cea","pager_element":0}}},"user":{"uid":0,"permissionsHash":"0c730a228c7c7fb09ef69cc49872503ed212ec963125de64d7bd9d3929d14bf0"}}</script> <script src="/sites/default/files/js/js_ChBLFJmLnJSY1j9tLrWbRTmJImKSKrgUmJ7S1dxzYdk.js?scope=footer&delta=0&language=en&theme=ucsf&include=eJxlkFtuAyEMRTdEh48uCHnAmXFjMMImKV19yEOJRv2x0AF8j248YyKTFsa3UajcNyrqr7hGyVUKFlOXwIBhYPMr7nAhaepUIgGHPH9DYCpn9f_RYjtmdDrUMPsVFF1kUB2Hc0ZV2FBdlIa-SMvA9IeuRz35jWUFdkO69RXDBszYxgt_qY0ZtDk1MFKjqD61XoGXD3EXwqv6x1yypM54QPADv88s5GlbLJwg4ZHoVUT3J7uPAG2uZgwmdUaEad4wWtgR0t2nQoOtQd3fPh-y9FL7yqQ7JncittlrhGok5RgqF2wMNSS0uft9_ch_dU1Rir5woflegRWhxadrgCSzNCjA41HOB94A9j3G5w"></script> <script src="https://kit.fontawesome.com/0047baebb3.js" crossorigin="anonymous"></script> <script src="/sites/default/files/js/js_DGHzI4C8s2m5srCR8I7slhej7nbVRHo8VPE5sxHlbEQ.js?scope=footer&delta=2&language=en&theme=ucsf&include=eJxlkFtuAyEMRTdEh48uCHnAmXFjMMImKV19yEOJRv2x0AF8j248YyKTFsa3UajcNyrqr7hGyVUKFlOXwIBhYPMr7nAhaepUIgGHPH9DYCpn9f_RYjtmdDrUMPsVFF1kUB2Hc0ZV2FBdlIa-SMvA9IeuRz35jWUFdkO69RXDBszYxgt_qY0ZtDk1MFKjqD61XoGXD3EXwqv6x1yypM54QPADv88s5GlbLJwg4ZHoVUT3J7uPAG2uZgwmdUaEad4wWtgR0t2nQoOtQd3fPh-y9FL7yqQ7JncittlrhGok5RgqF2wMNSS0uft9_ch_dU1Rir5woflegRWhxadrgCSzNCjA41HOB94A9j3G5w"></script> <script type="text/javascript"> /*<![CDATA[*/ (function() { var sz = document.createElement('script'); sz.type = 'text/javascript'; sz.async = true; sz.src = '//siteimproveanalytics.com/js/siteanalyze_8343.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(sz, s); })(); /*]]>*/ </script> </body> </html>

CINXE.COM

1 Genomic Test Can Diagnose Nearly Any Infection | UC San Francisco