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ds2-5-body-sm ds2-5-body-link" data-author-id="49474860" href="https://independent.academia.edu/StephenTatter">Stephen Tatter</a></div><p class="ds-related-work--metadata ds2-5-body-xs">NeuroRehabilitation, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep brain stimulation: Treating neurological and psychiatric disorders by modulating brain activity","attachmentId":92041638,"attachmentType":"pdf","work_url":"https://www.academia.edu/87959524/Deep_brain_stimulation_Treating_neurological_and_psychiatric_disorders_by_modulating_brain_activity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/87959524/Deep_brain_stimulation_Treating_neurological_and_psychiatric_disorders_by_modulating_brain_activity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="73209165" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73209165/History_Applications_and_Mechanisms_of_Deep_Brain_Stimulation">History, Applications, and Mechanisms of Deep Brain Stimulation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="164003640" href="https://independent.academia.edu/SuvarchalaSomayajula">Suvarchala Somayajula</a></div><p class="ds-related-work--metadata ds2-5-body-xs">JAMA Neurology, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"History, Applications, and Mechanisms of Deep Brain Stimulation","attachmentId":81818432,"attachmentType":"pdf","work_url":"https://www.academia.edu/73209165/History_Applications_and_Mechanisms_of_Deep_Brain_Stimulation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/73209165/History_Applications_and_Mechanisms_of_Deep_Brain_Stimulation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="101082271" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101082271/Treatment_of_neurological_and_psychiatric_disorders_with_deep_brain_stimulation_raising_hopes_and_future_challenges">Treatment of neurological and psychiatric disorders with deep brain stimulation; raising hopes and future challenges</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="242526033" href="https://independent.academia.edu/SharifSharifi6">Sharif Sharifi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Basic and clinical neuroscience, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">The technology of Neural Stimulation in recent years has become the focus of the research and treatment, although it has been around for many years. The potential use of stimulating the brain and nerves ranges from the spinal cord stimulation to the implantations of cochlear and bionic eyes with a large discrepancy between the clinical readiness for these various uses. Electrical high-frequency Deep Brain Stimulation (DBS) was developed as an alternative option to treat a few neurological disorders. However, with advancing in surgical procedures, technologies and safeties, the applications of DBS are expanding not only for therapeutic purposes but also for research. Although the exact mechanisms of action/s are not fully understood, the outcome of the ongoing research and clinical trials are promising. DBS has been used to treat the essential tremor since 1997, Parkinson&#39;s disease (PD) since 2002 and dystonia since 2003. It has also been used to treat various disorders, includin...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Treatment of neurological and psychiatric disorders with deep brain stimulation; raising hopes and future challenges","attachmentId":101719938,"attachmentType":"pdf","work_url":"https://www.academia.edu/101082271/Treatment_of_neurological_and_psychiatric_disorders_with_deep_brain_stimulation_raising_hopes_and_future_challenges","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/101082271/Treatment_of_neurological_and_psychiatric_disorders_with_deep_brain_stimulation_raising_hopes_and_future_challenges"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="11913363" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/11913363/Deep_brain_stimulation_for_neurological_and_psychiatric_disorders">Deep brain stimulation for neurological and psychiatric disorders</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4281291" href="https://dovepress.academia.edu/AdieChan">Dove Medical Press</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Abstract: Deep brain stimulation (DBS) has become a well-accepted therapy to treat movement disorders, including Parkinson’s disease, essential tremor, and dystonia. Read this review and sign up to receive Neuropsychiatric Disease and Treatment journal here: http://www.dovepress.com/articles.php?article_id=21242</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep brain stimulation for neurological and psychiatric disorders","attachmentId":37284221,"attachmentType":"pdf","work_url":"https://www.academia.edu/11913363/Deep_brain_stimulation_for_neurological_and_psychiatric_disorders","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/11913363/Deep_brain_stimulation_for_neurological_and_psychiatric_disorders"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="18065257" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18065257/Time_to_Reconsider_Deep_Brain_Stimulation">Time to Reconsider Deep Brain Stimulation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2215144" href="https://independent.academia.edu/RonBerghmans">Ron Berghmans</a></div><p class="ds-related-work--metadata ds2-5-body-xs">AJOB Neuroscience, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Time to Reconsider Deep Brain Stimulation","attachmentId":39856938,"attachmentType":"pdf","work_url":"https://www.academia.edu/18065257/Time_to_Reconsider_Deep_Brain_Stimulation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18065257/Time_to_Reconsider_Deep_Brain_Stimulation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="43772078" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43772078/Potential_indications_for_deep_brain_stimulation_in_neurological_disorders_an_evolving_field">Potential indications for deep brain stimulation in neurological disorders: an evolving field</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36291984" href="https://itesm.academia.edu/DanielMartinezRamirez">Daniel Martinez-Ramirez</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Deep brain stimulation (DBS) is an established therapy for appropriately selected patients with movement disorders and neuropsychiatric conditions. Although the exact mechanisms and biology of DBS are not fully understood, it is a safe and well-tolerated therapy for many refractory cases of neuropsy-chiatric disease. Increasingly, DBS has been explored in other conditions with encouraging results. In this paper, available data is reviewed and new DBS targets, challenges and future directions in neurological disorders are explored. A detailed search of the medical literature discussing the potential use of DBS for neurological disorders excluding accepted indications was conducted. All reports were analyzed individually for content and redundant articles were excluded by examining individual abstracts. The level of evidence for each indication was summarized. Multiple studies report promising preliminary data regarding the safety and efficacy of DBS for a variety of neurological indications including chronic pain, tinnitus, epilepsy, Tourette syndrome, Huntington's disease, tardive dyskinesia and Alzheimer's disease. The initial results of DBS studies for diverse neurological disorders are encouraging but larger, controlled, prospective, homogeneous clinical trials are necessary to establish long-term safety and effectiveness. The field of neuromodulation continues to evolve and advances in DBS technology, stereotactic techniques, neu-roimaging and DBS programming capabilities are shaping the present and future of DBS research and use in practice.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Potential indications for deep brain stimulation in neurological disorders: an evolving field","attachmentId":64085508,"attachmentType":"pdf","work_url":"https://www.academia.edu/43772078/Potential_indications_for_deep_brain_stimulation_in_neurological_disorders_an_evolving_field","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/43772078/Potential_indications_for_deep_brain_stimulation_in_neurological_disorders_an_evolving_field"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="16410066" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16410066/Deep_brain_stimulation_Can_we_do_it_better">Deep brain stimulation: Can we do it better?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35553858" href="https://independent.academia.edu/MicheleTagliati">Michele Tagliati</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Neurophysiology, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep brain stimulation: Can we do it better?","attachmentId":42494704,"attachmentType":"pdf","work_url":"https://www.academia.edu/16410066/Deep_brain_stimulation_Can_we_do_it_better","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16410066/Deep_brain_stimulation_Can_we_do_it_better"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="63531014" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63531014/Deep_Brain_Stimulation_in_Neurological_and_Psychiatric_Disorders">Deep Brain Stimulation in Neurological and Psychiatric Disorders</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="867501" href="https://imtek.academia.edu/ThomasESchlaepfer">Thomas E. Schlaepfer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep Brain Stimulation in Neurological and Psychiatric Disorders","attachmentId":75931757,"attachmentType":"pdf","work_url":"https://www.academia.edu/63531014/Deep_Brain_Stimulation_in_Neurological_and_Psychiatric_Disorders","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63531014/Deep_Brain_Stimulation_in_Neurological_and_Psychiatric_Disorders"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="71615153" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/71615153/Origin_and_Evolution_of_Deep_Brain_Stimulation">Origin and Evolution of Deep Brain Stimulation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="173650318" href="https://independent.academia.edu/VittorioAlessandroSironi">Vittorio Alessandro Sironi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Integrative Neuroscience, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">This paper briefly describes how the electrical stimulation, used since antiquity to modulate the nervous system, has been a fundamental tool of neurophysiologic investigation in the second half of the eighteenth century and was subsequently used by the early twentieth century, even for therapeutic purposes. In mid-twentieth century the advent of stereotactic procedures has allowed the drift from lesional to stimulating technique of deep nuclei of the brain for therapeutic purposes. In this way, deep brain stimulation (DBS) was born, that, over the last two decades, has led to positive results for the treatment of medically refractory Parkinson’s disease, essential tremor, and dystonia. In recent years, the indications for therapeutic use of DBS have been extended to epilepsy, Tourette’s syndrome, psychiatric diseases (depression, obsessive–compulsive disorder), some kinds of headache, eating disorders, and the minimally conscious state. 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Broggi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurological Sciences, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Targeting the brain: considerations in 332 consecutive patients treated by deep brain stimulation (DBS) for severe neurological diseases","attachmentId":49803304,"attachmentType":"pdf","work_url":"https://www.academia.edu/29360466/Targeting_the_brain_considerations_in_332_consecutive_patients_treated_by_deep_brain_stimulation_DBS_for_severe_neurological_diseases","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/29360466/Targeting_the_brain_considerations_in_332_consecutive_patients_treated_by_deep_brain_stimulation_DBS_for_severe_neurological_diseases"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="56217570" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56217570/Deep_brain_stimulation_from_neurology_to_psychiatry">Deep brain stimulation: from neurology to psychiatry?</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35899240" href="https://independent.academia.edu/ChristelleBaunez">Christelle Baunez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Trends in Neurosciences, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep brain stimulation: from neurology to psychiatry?","attachmentId":71717066,"attachmentType":"pdf","work_url":"https://www.academia.edu/56217570/Deep_brain_stimulation_from_neurology_to_psychiatry","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/56217570/Deep_brain_stimulation_from_neurology_to_psychiatry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div 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href="https://www.academia.edu/82536662/Deep_Brain_Stimulation_Technology_at_the_Cutting_Edge">Deep Brain Stimulation: Technology at the Cutting Edge</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="209415998" href="https://independent.academia.edu/Changsuyoune">su youne Chang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical Neurology, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep Brain Stimulation: Technology at the Cutting Edge","attachmentId":88218317,"attachmentType":"pdf","work_url":"https://www.academia.edu/82536662/Deep_Brain_Stimulation_Technology_at_the_Cutting_Edge","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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data-collection-position="14" data-entity-id="99173945" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99173945/Proceedings_of_the_Ninth_Annual_Deep_Brain_Stimulation_Think_Tank_Advances_in_Cutting_Edge_Technologies_Artificial_Intelligence_Neuromodulation_Neuroethics_Pain_Interventional_Psychiatry_Epilepsy_and_Traumatic_Brain_Injury">Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217447091" href="https://independent.academia.edu/DianeDiEuliis">Diane DiEuliis</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Human Neuroscience, 2022</p><div 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data-collection-position="16" data-entity-id="46968986" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/46968986/A_critical_reflection_on_the_technological_development_of_deep_brain_stimulation_DBS_">A critical reflection on the technological development of deep brain stimulation (DBS)</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="130786891" href="https://uzh.academia.edu/ChristianIneichen">Christian Ineichen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Human Neuroscience, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A critical reflection on the technological development of deep brain stimulation 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