Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T2 Contrast Agent

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<ul class="nav navbar-nav navbar-right" style="display: inline-flex; align-items: center; margin-left: 20px;"> <li id="language"> <a href="javascript:"> <div class="current"> <i class="ivu-icon ivu-icon-md-globe"></i> 中文 </div> </a> <div class="selection"> <a rel="alternate" hreflang="en" href="https://www.peeref.com/works/1919256" > <span>English</span> </a> <a rel="alternate" hreflang="zh" href="https://www.peeref.com/zh/works/1919256" > <span>中文</span> </a> </div> </li> </ul> </ul> </div> </nav> <main> <div id="top-info-banner" class="container-fluid mb-0"> <div class="container"> <div class="d-flex align-items-center" style="margin-top: 30px;"> <span class="text-white"> <strong class="f18">☆</strong> <span class="f16">4.7</span> </span> <span class="mx-3"></span> <span class="tag">Article</span> </div> <h1 class="title title-for-article"> Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T2 Contrast Agent </h1> <div class="help-links-left"> <p class="pub-info"> BIOCONJUGATE CHEMISTRY (2017) </p> </div> </div> </div> <div id="article-sticky-navbar"> <div class="container"> <div class="d-flex justify-content-between flex-wrap flex-md-nowrap"> <div class="d-flex align-items-center mb-2"> <ul class="nav nav-underline f16 font-weight-bold"> <li class="active"> <a href="javascript:;"> 总览 </a> </li> <li class=""> <a href="https://www.peeref.com/zh/works/1919256/comments"> 撰写评论 </a> </li> </ul> </div> <div class="d-flex align-items-center justify-content-md-end flex-wrap flex-md-nowrap"> <div class="mr-3 mt-3 mt-md-0 flex-shrink-0"> <a href="https://doi.org/10.1021/acs.bioconjchem.6b00577" target="_blank" class="btn btn-warning btn-circle"> <i class="ivu-icon ivu-icon-md-copy f16"></i> <strong>获取全文</strong> </a> </div> <div class="mr-3 mt-3 mt-md-0 flex-shrink-0"> <a href="https://www.peeref.com/zh/works/1919256/add-to-collection" class="btn btn-success btn-circle"> <strong>添加到收藏夹</strong> </a> </div> <div class="mr-3 mt-3 mt-md-0 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panel-box rounded shadow-none border"> <div class="mb-3 pb-3"> <h4 class="mt-0">期刊</h4> <div class="f16"> <h5 class="title f16"> <a href="https://www.peeref.com/zh/journals/1102/bioconjugate-chemistry"> BIOCONJUGATE CHEMISTRY </a> </h5> <span> 卷 28, 期 1, 页码 161-170 </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">出版社</h4> <div class="f16"> <h5 class="title f16 text-primary"> AMER CHEMICAL SOC </h5> <div class="my-2"> DOI: 10.1021/acs.bioconjchem.6b00577 </div> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">关键词</h4> <div class="f16"> - </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">类别</h4> <div class="f16"> <span class="d-block"> <a href="https://www.peeref.com/zh/works/list?category=Biochemical+Research+Methods" target="_blank" class="text-dark btn btn-link p-0 text-left"> Biochemical Research Methods </a> </span> <span class="d-block"> <a href="https://www.peeref.com/zh/works/list?category=Biochemistry+%26+Molecular+Biology" target="_blank" class="text-dark btn btn-link p-0 text-left"> Biochemistry & Molecular Biology </a> </span> <span class="d-block"> <a href="https://www.peeref.com/zh/works/list?category=Chemistry%2C+Multidisciplinary" target="_blank" class="text-dark btn btn-link p-0 text-left"> Chemistry, Multidisciplinary </a> </span> <span class="d-block"> <a href="https://www.peeref.com/zh/works/list?category=Chemistry%2C+Organic" target="_blank" class="text-dark btn btn-link p-0 text-left"> Chemistry, Organic </a> </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">资金</h4> <div class="f16"> <ol class=""> <li>Italian Ministry of Health [GR-2009-1579848]</li> <li>AIRC Foundation [IG 11723]</li> <li>Besta5x1000</li> <li>EU Theraglio FP7-Health-Innovation Grant [602923]</li> </ol> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 text-center">向作者/读者索取更多资源</h4> <div class="requests"> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/file.png" alt=""> </div> <h4>Protocol</h4> <p> <a href="https://www.peeref.com/zh/works/1919256/resource" class="btn btn-outline-primary btn-sm"> 社区支持 </a> </p> </div> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/experiment.png" alt=""> </div> <h4>Reagent</h4> <p> <a href="https://www.peeref.com/zh/works/1919256/resource" class="btn btn-outline-primary btn-sm"> 社区支持 </a> </p> </div> </div> </div> </div> <div class="col-md-8 px-0 pl-md-3"> <div id="article-summary-panel" class="mb-4"> <ul class="nav nav-tabs" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#raw_abstract" data-toggle="tab" class="abstract-tab mx-0 f16 text-dark"> <strong>摘要</strong> </a> </li> </ul> <div class="tab-content border border-top-0"> <div id="raw_abstract" class="tab-pane active"> <div class="abstract-panel panel-box mb-0 rounded shadow-none"> <div class="f16">Nanoparticle-based magnetic resonance imaging T-2 negative agents are of great interest, and much effort is devoted to increasing cell loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nano particles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K. Furthermore, preliminary cellular studies reveal that both Au/Fe NPs show very limited toxicity. MRI phantom experiments show that r(2)/r(1) ratio of Au/Fe NPs is as high as 670, leading to a 66% reduction in T-2 relaxation time. These nanoparticles provide great versatility and potential for nanopartide-based diagnostics and therapeutic applications and as imaging contrast agents.</div> </div> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">作者</h4> <div class="mb-3"> <article-authors tid="1919256" list="[{"name":"Fernanda Sousa","sequence":1},{"name":"Barbara Sanavio","sequence":2},{"name":"Alessandra Saccani","sequence":3},{"name":"Yun Tang","sequence":4},{"name":"Ileana Zucca","sequence":5},{"name":"Tamara M. Carney","sequence":6},{"name":"Alfonso Mastropietro","sequence":7},{"name":"Paulo H. Jacob Silva","sequence":8},{"name":"Randy P. Carney","sequence":9},{"name":"Kurt Schenk","sequence":10},{"name":"Arash O. Omrani","sequence":11},{"name":"Ping Huang","sequence":12},{"name":"Lin Yang","sequence":13},{"name":"Henrik M. Ronnow","sequence":14},{"name":"Francesco Stellacci","sequence":15},{"name":"Silke Krol","sequence":16}]" verified="[]" page="work" ></article-authors> </div> <div class="alert alert-warning mb-0"> <h5 class="mt-0 bg-warning text-dark px-3 rounded d-inline-block"> 我是这篇论文的作者 </h5> <div class="font-weight-bold f13"> 点击您的名字以认领此论文并将其添加到您的个人资料中。 </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">评论</h4> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="flex-grow-1"> <h4 class="f16"> 主要评分 <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="主要评分表示论文的整体质量水平。"> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap align-items-center alert mb-0"> <div class="d-flex align-items-center justify-content-center"> <Rate disabled allow-half value="4.7" style="font-size: 28px;"></Rate> <strong class="f20 m-3" style="color: #f5a623;">4.7</strong> </div> <div class="text-muted mx-4"> 评分不足 </div> </div> <h4 class="f16"> 次要评分 <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="次要评分独立反映论文的优点或缺点。"> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap alert"> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">新颖性</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">重要性</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">科学严谨性</h5> <strong class="mx-4">-</strong> </div> </div> </div> <div class="flex-shrink-0"> <div class="border bg-light py-2 px-4"> <h5 class="mb-1">评价这篇论文</h5> <Rate class="f24" @on-change="function(value){ location.href='https://www.peeref.com/zh/works/1919256/comments?rating='+value }"></Rate> </div> </div> </div> </div> <div id="collection" class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">推荐</h4> <div class="my-3"> <ul class="nav nav-pills border-bottom pb-3" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#articles_from_related" data-toggle="tab" class="mx-0 f15"> <strong>相关</strong> </a> </li> <li class=""> <a href="#articles_from_authors" data-toggle="tab" class="mx-0 f15"> <strong>来自同一作者</strong> </a> </li> <li class=""> <a href="#articles_from_journal" data-toggle="tab" class="mx-0 f15"> <strong>来自同一期刊</strong> </a> </li> </ul> <div class="tab-content"> <div id="articles_from_related" class="tab-pane active"> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Nanoscience & Nanotechnology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/22812224" class="text-dark hover-underline">Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging</a> </h4> <p class="text-ellipsis-2">Can Chen, Jianxian Ge, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng, Mingyuan Gao</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/8110.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/22812224/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/21284294" class="text-dark hover-underline">An Ultrahigh-Field-Tailored T1-T2 Dual-Mode MRI Contrast Agent for High-Performance Vascular Imaging</a> </h4> <p class="text-ellipsis-2">Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/209.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ADVANCED MATERIALS</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/21284294/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Materials Science, Biomaterials </span> </div> <h4> <a href="https://www.peeref.com/zh/works/35610199" class="text-dark hover-underline">Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T1-T2 dual-mode magnetic resonance imaging probes</a> </h4> <p class="text-ellipsis-2">Li Yang, Shengxiang Fu, Zhongyuan Cai, Li Liu, Chunchao Xia, Qiyong Gong, Bin Song, Hua Ai</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10660.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The T-1-T-2 dual-mode MRI probes can acquire comprehensive information of different tissues simultaneously, showing good stability and non-cytotoxicity. They are suitable for imaging blood vessels and liver tissue. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">REGENERATIVE BIOMATERIALS</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/35610199/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27540376" class="text-dark hover-underline">A tumor-associated bacteria-responsive magnetic exosome as a clearable T1 contrast agent for targeted imaging of tumors</a> </h4> <p class="text-ellipsis-2">Xiaoqing Wei, Dan Mu, Yingping Li, Jingya Zhao, Shaobing Zhou</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6034.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NANO TODAY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27540376/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27156397" class="text-dark hover-underline">Gadolinium (III)-Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent</a> </h4> <p class="text-ellipsis-2">Xiangyu Chen, Shiyong Teng, Jinming Li, Xuezhi Qiao, Weidong Zhao, Zhengjie Xue, Xudong Shi, Yuguang Wang, Wensheng Yang, Tie Wang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/209.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Magnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd-DTPA), have limited blood circulation time due to rapid clearance by the kidney, which hinders the improvement of contrast between tumors and normal tissue. To address this issue, a novel MRI contrast agent using deformable mesoporous organosilica nanoparticles (D-MON) incorporating Gd-DTPA is fabricated. In vivo distribution studies show that the D-MON-based contrast agent can prolong blood circulation time and achieve high-contrast imaging in tumor tissue, surpassing the performance of the clinical contrast agent Gd-DTPA. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ADVANCED MATERIALS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27156397/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27918621" class="text-dark hover-underline">Synthesis of Fe3O4-Gold hybrid nanoparticles coated by bovine serum albumin as a contrast agent in MR imaging</a> </h4> <p class="text-ellipsis-2">Hossein Danafar, Yasamin Baghdadchi, Murat Barsbay, Mohammadreza Ghaffarlou, Navid Mousazadeh, Ali Mohammadi</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/11459.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Insufficient contrast is a limitation of MRI, which can be overcome by using contrast agents. Nano-sized contrast materials, such as Fe3O4-Au hybrid NPs, have unique advantages but suffer from aggregation and accumulation. Surface modifications, like coating with BSA, are necessary to improve their stability and biocompatibility. The synthesized Fe3O4-Au-BSA NPs showed a significant reduction in signal intensity on MR images, confirming their contrast ability. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">HELIYON</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27918621/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/21625809" class="text-dark hover-underline">A Novel Mesoporous Superparamagnetic Hybrid Silica/Hydroxyapatite Nanocomposite as MRI Contrast Agent</a> </h4> <p class="text-ellipsis-2">Mehraneh Kermanian, Somayeh Sadighian, Ali Ramazani, Mehran Naghibi, Seyed Hojjat Hosseini</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10229.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> A novel magnetic hybrid silica/hydroxyapatite nanocomposite, MSFeHA, was successfully synthesized and studied as an MRI T2 contrast agent. The biocompatibility and bioaccumulation of the nanocomposite were evaluated through a series of experiments, showing potential clinical application value. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">CHEMNANOMAT</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/21625809/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Physical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83385839" class="text-dark hover-underline">Lanthanide vanadate-based nanoparticles as multimodal T1 1-T2 T 2 MRI contrast agent and NIR luminescent imaging probe</a> </h4> <p class="text-ellipsis-2">Elisabet Gomez-Gonzalez, Nuria O. Nunez, Carlos Caro, Maria L. Garcia-Martin, Ana I. Becerro, Manuel Ocana</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/4110.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> A multimodal lanthanide vanadate system was developed for use as a dual T1 1-T2 2 MRI contrast agent and a luminescent imaging probe in the near-infrared region. The core-shell structure was found to be more suitable by comparing the magnetic relaxivities of two different NPs architectures. Then, Nd3+ 3 + cations were doped into the GdVO4 4 layer, and an inert YVO4 4 intermediate shell was introduced to prepare the multimodal nanoparticles. These nanoparticles showed good magnetic relaxivity and luminescence properties, were stable and non-toxic in physiological media, and met the requirements for use as a contrast agent and imaging probe. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF ALLOYS AND COMPOUNDS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83385839/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/81715923" class="text-dark hover-underline">Enhancing MRI through high loading of superparamagnetic nanogels with high sensitivity to the tumor environment</a> </h4> <p class="text-ellipsis-2">Jinfeng Liao, Liangyu Zhou, Yongzhi Wu, Zhiyong Qian, Pei Li</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/11128.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study presents a novel hybrid nanogel that exhibits temperature and pH sensitivity, enabling magnetic targeting and enhanced diagnosis via MRI. The nanogel is composed of iron oxide nanoparticles and poly(N-isopropylacrylamide)/polyacrylamide/chitosan, and its synthesis involves a surfactant-free emulsion copolymerization process. Experiments demonstrated the good performance of this nanogel in animal models, showing its potential as a magnetic targeting contrast agent. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NANOSCALE ADVANCES</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/81715923/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Nanoscience & Nanotechnology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/21414193" class="text-dark hover-underline">Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent</a> </h4> <p class="text-ellipsis-2">Li-Hua Deng, Hai Jiang, Fu-Lin Lu, Han-Wei Wang, Yu Pu, Chang-Qiang Wu, Hong-Jie Tang, Ye Xu, Tian-Wu Chen, Jiang Zhu, Cheng-Yi Shen, Xiao-Ming Zhang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/3815.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> By using PEGylated SPIO nanoparticles as MRI contrast agents, different nanocrystal sizes and PEG coatings can be utilized to achieve T-1, T-2, or T-1-T-2 dual-mode imaging at different magnetic field intensities. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">INTERNATIONAL JOURNAL OF NANOMEDICINE</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/21414193/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Biochemistry & Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82255294" class="text-dark hover-underline">Rational Design of Magnetic Nanoparticles as T1-T2 Dual-Mode MRI Contrast Agents</a> </h4> <p class="text-ellipsis-2">Carlos F. G. C. Geraldes</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/5991.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This review summarizes the research progress of magnetic nanoparticles as MRI contrast agents, focusing on the development and optimization of dual-mode T-1-T-2 MRI contrast agents containing Gd, Mn, Fe, and other lanthanide ions. The article discusses the magnetic properties, relaxivity ratios, and design strategies of contrast agents, and presents some examples of in vivo preclinical applications. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">MOLECULES</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82255294/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Materials Science, Biomaterials </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83599920" class="text-dark hover-underline">Sodium lanthanide tungstate-based nanoparticles as bimodal contrast agents for in vivo high-field MRI and CT imaging</a> </h4> <p class="text-ellipsis-2">Elisabet Gomez-Gonzalez, Carlos Caro, Nuria O. Nunez, Daniel Gonzalez-Mancebo, Jesus D. Urbano-Gamez, Maria L. Garcia-Martin, Manuel Ocana</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/9525.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> In this work, we prepared uniform NaDy(WO4)(2) and NaHo(WO4)(2) nanoparticles, which were dispersible and nontoxic for cells. Both NPs exhibited satisfactory magnetic relaxivities at 9.4 T, making them suitable as contrast agents for HF-MRI. Moreover, they accumulated significantly in tumors, making them suitable for tumor detection. Finally, NaDy(WO4)(2) NPs showed superior X-ray attenuation capability, making them suitable as dual-probes for both HF-MRI and CT imaging. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF MATERIALS CHEMISTRY B</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83599920/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biotechnology & Applied Microbiology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/24941950" class="text-dark hover-underline">Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice</a> </h4> <p class="text-ellipsis-2">Heyu Yang, Hui Wang, Chenghao Wen, Shun Bai, Pengfei Wei, Bo Xu, Yunjun Xu, Chaozhao Liang, Yunjiao Zhang, Guilong Zhang, Huiqin Wen, Li Zhang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/9529.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study aimed to evaluate the effects of iron oxide nanoparticles (IONPs) on the male reproductive system of mice. The results showed that IONPs did not affect the major organs, but caused damage to Sertoli cells in the blood-testis barrier (BTB) at a relatively high concentration. This led to a temporary reduction in sperm quantity and quality, which was attributed to increased oxidative stress and apoptotic activity in the epididymis. However, these effects were reversible and returned to normal within 14 days after injection of IONPs. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF NANOBIOTECHNOLOGY</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/24941950/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/20450384" class="text-dark hover-underline">Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging: Fundamentals, Challenges, Applications, and Prospectives</a> </h4> <p class="text-ellipsis-2">Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/209.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ADVANCED MATERIALS</span> (2021) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/20450384/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry & Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/25904583" class="text-dark hover-underline">Galactomannan armed superparamagnetic iron oxide nanoparticles as a folate receptor targeted multi-functional theranostic agent in the management of cancer</a> </h4> <p class="text-ellipsis-2">R. Shiji, Manu M. Joseph, Anitha Sen, K. Raveendran Pillai, Bs Unnikrishnan, T. T. Sreelekha</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/3674.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study modified superparamagnetic iron oxide nanoparticles (SPIONs) using an eco-friendly substance extracted from pomegranate fruit peel, which resulted in tumor-targeted accumulation and improved biocompatibility. By attaching an anticancer drug to the modified nanoparticles, the drug could be selectively released in tumor cells, leading to improved tumor reduction and survival benefits. The modified nanoparticles also exhibited remarkable contrast in magnetic resonance imaging (MRI) for targeted tumor therapy. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/25904583/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> <div id="articles_from_authors" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82557507" class="text-dark hover-underline">Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation</a> </h4> <p class="text-ellipsis-2">Quy Ong, Xu Xufeng, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study presents a novel universal capillary-cell design for analytical ultracentrifugation-sedimentation equilibrium, which solves the problem of difficult and unreliable handling of existing research equipment and can be used to study high-concentration samples with a success rate close to 100%. The design creates a liquid reservoir on the bottom window of the AUC cell by laser ablation or mechanical drilling, which is easy to use, robust, reusable, and suitable for samples in aqueous and organic solvents. The study also demonstrates the practicality of the cell through experiments, including studying the equation of state and second virial coefficients of concentrated gold nanoparticle dispersions, the gelation phase transition of DNA and BSA solutions, and the liquid-liquid phase separation of concentrated BSA/PEG droplets. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82557507/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Physical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83029524" class="text-dark hover-underline">Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions in an Additive Way</a> </h4> <p class="text-ellipsis-2">Xufeng Xu, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study shows that PPI measured in test tubes and cells differ due to the complexity of the intracellular environment. AAs and their derivatives can make protein dispersions more stable, and different AA derivatives, AA mixtures, and short peptides can all effectively modulate PPI, with additive effects. This study provides insights for designing biocompatible molecules to stabilize protein interactions. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF PHYSICAL CHEMISTRY LETTERS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83029524/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Materials Science, Biomaterials </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82133878" class="text-dark hover-underline">Extracellular Vesicles from Highly Metastatic Osteosarcoma Cells Induce Pro-Tumorigenic Macrophage Phenotypes</a> </h4> <p class="text-ellipsis-2">Katherine H. Griffin, Rachel R. Mizenko, Vishalakshi Arun, Randy P. Carney, J. Kent Leach</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study compared the effects of extracellular vesicles (EVs) from osteosarcoma cells with different metastatic potential on macrophages, and found that EVs from the more metastatic cell line could reduce the proportion of M1 macrophages, creating a more tumor-permissive environment, which may be related to CD47 on the surface of EVs. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ADVANCED BIOLOGY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82133878/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83407020" class="text-dark hover-underline">Nature-inspired recycling of a protein mixture into a green fluorescent protein-based hydrogel</a> </h4> <p class="text-ellipsis-2">Laura Roset Julia, Sebastian J. Maerkl, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Protein-based materials have various remarkable properties and are widely used. In nature, proteins can be recycled in multiple ways, and protein metabolism is a great example. In this process, a random mixture of proteins is digested into amino acids, which can then be used by cells to synthesize the needed proteins. Recently, researchers have demonstrated that the protein recycling process can be performed in vitro and named it NaCRe. In previous experiments, they could only produce a small amount of recycled protein in the microgram scale from various protein mixtures. Here, they show that NaCRe can convert a milligram protein mixture containing silk into a milligram of green fluorescent protein hydrogel. They also indicate that for NaCRe to be effective, the starting protein mixture must contain a good balance of all AAs, and discuss the challenges encountered when scaling up NaCRe. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">RSC SUSTAINABILITY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83407020/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Immunology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83454110" class="text-dark hover-underline">Feline Infectious Peritonitis mRNA Vaccine Elicits Both Humoral and Cellular Immune Responses in Mice</a> </h4> <p class="text-ellipsis-2">Terza Brostoff, Hannah P. Savage, Kenneth A. Jackson, Joseph C. Dutra, Justin H. Fontaine, Dennis J. Hartigan-O'Connor, Randy P. Carney, Patricia A. Pesavento</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study presents a lipid nanoparticle-encapsulated mRNA vaccine targeting feline coronavirus (FCoV) that overcomes the risk of antibody-dependent enhancement (ADE) by encoding the transcript for the internal structural nucleocapsid (N) FCoV protein. The vaccine is stable in vitro and capable of eliciting an immune response in mice, providing justification for beginning safety and efficacy trials in cats. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">VACCINES</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83454110/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biophysics </span> </div> <h4> <a href="https://www.peeref.com/zh/works/81742520" class="text-dark hover-underline">Positional contrastive learning for improved thigh muscle segmentation in MR images</a> </h4> <p class="text-ellipsis-2">Nicola Casali, Elisa Scalco, Maria Giovanna Taccogna, Fulvio Lauretani, Simone Porcelli, Andrea Ciuni, Alfonso Mastropietro, Giovanna Rizzo</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> We propose a positional contrastive self-supervised learning method for thigh muscle segmentation and evaluate it on limited annotated data. The results show that the method can significantly improve the segmentation performance when using a very limited number of labeled volumes, and can also achieve enhancements when using all labeled objects. This has potential implications for accelerating the annotation process in the clinic. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NMR IN BIOMEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/81742520/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Physical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83417312" class="text-dark hover-underline">Modulating Weak Protein-Protein Cross-Interactions by the Addition of Free Amino Acids at Millimolar Concentrations</a> </h4> <p class="text-ellipsis-2">Pamina M. Winkler, Cecilia Siri, Johann Buczkowski, Juliana V. C. Silva, Lionel Bovetto, Christophe Schmitt, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study quantified weak protein-protein interactions in solution using cross-interaction chromatography (CIC) and surface plasmon resonance (SPR), and demonstrated that they can be modulated by adding millimolar concentrations of free amino acids. The second osmotic virial cross-interaction coefficient (B-23) was determined as a proxy for the interaction strength between two different proteins using CIC, and the binding affinity between the same proteins was established using SPR. The results showed that amino acids proline, glutamine, and arginine can make the protein cross-interactions more repulsive or equivalently less attractive, and this modulation does not alter the protein's secondary structure. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF PHYSICAL CHEMISTRY B</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83417312/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83494557" class="text-dark hover-underline">Assessing the conjugation efficiency of surface-modified extracellular vesicles using single nanovesicle analysis technologies</a> </h4> <p class="text-ellipsis-2">Leora Goldbloom-Helzner, Harjn Bains, Emma G. Loll, Tanner Henson, Rachel R. Mizenko, Priyadarsini Kumar, Cheemeng Tan, Diana L. Farmer, Randy P. Carney, Aijun Wang</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This article introduces the role of extracellular vesicles (EVs) in cell-cell communication and drug delivery, as well as the importance of their surface modification and targeted delivery. However, the heterogeneity of EVs is a major bottleneck for their clinical translation. Therefore, this article designs the EV surface at the single-vesicle level and applies orthogonal platforms with single vesicle resolution to determine and optimize the efficiency of conjugating the myelin-targeting aptamer LJM-3064 to single EVs. The results show that the conjugation of aptamers to single EVs depends on the size of EVs, which emphasizes the importance of single vesicle analysis for engineering EVs and provides a novel single-EV-based framework for modifying EV surfaces. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NANOSCALE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83494557/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biotechnology & Applied Microbiology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83164340" class="text-dark hover-underline">Classification of Muscular Dystrophies from MR Images Improves Using the Swin Transformer Deep Learning Model</a> </h4> <p class="text-ellipsis-2">Alfonso Mastropietro, Nicola Casali, Maria Giovanna Taccogna, Maria Grazia D'Angelo, Giovanna Rizzo, Denis Peruzzo</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study investigated the performance of SwinT and CNN in classifying neuromuscular disorders using skeletal muscle MRI scans. The results showed that SwinT had higher accuracy, especially when using fat fraction images as input. The study also suggested that AI-driven approaches have potential applications in precise classification of neuromuscular disorders and improving patient care. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOENGINEERING-BASEL</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83164340/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Cell Biology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83548636" class="text-dark hover-underline">Plasma-derived extracellular vesicles (EVs) as biomarkers of sepsis in burn patients via label-free Raman spectroscopy</a> </h4> <p class="text-ellipsis-2">Hannah J. O'Toole, Neona M. Lowe, Vishalakshi Arun, Anna V. Kolesov, Tina L. Palmieri, Nam K. Tran, Randy P. Carney</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study discusses the severity and diagnostic challenges of sepsis after burn trauma, proposes the use of circulating extracellular vesicles (EVs) from patient liquid biopsies as sepsis biomarkers, and presents the application of Raman spectroscopy in detecting sepsis in burn patients. The technique is rapid, sensitive, and specific, capable of detecting specific glycoconjugates of bacterial strains associated with sepsis. This work provides potential for the use of EVs as biomarkers in clinical burn trauma care and establishes a fast, label-free method to specifically identify features of bacterial EVs relevant to infection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF EXTRACELLULAR VESICLES</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83548636/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Cell Biology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84095225" class="text-dark hover-underline">A critical systematic review of extracellular vesicle clinical trials</a> </h4> <p class="text-ellipsis-2">Rachel R. Mizenko, Madison Feaver, Batuhan T. Bozkurt, Neona Lowe, Bryan Nguyen, Kuan-Wei Huang, Aijun Wang, Randy P. Carney</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study analyzed EV-related clinical trials, finding wide applications in diagnosis and cancer treatment, but with insufficient reporting of technical methods and limited use of EV subpopulations. With technological advancements, more refined EV trials are expected in the future, highlighting the importance of methodological reporting and EV subpopulation studies in promoting the development of personalized medicine. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF EXTRACELLULAR VESICLES</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84095225/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Physical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/81858404" class="text-dark hover-underline">Over-Reduced Core-Shell Au@CoO x -Co with Strong Interfacial Interactions for Photoassisted Peroxymonosulfate Activation</a> </h4> <p class="text-ellipsis-2">Wenhao Xu, Yujie Cao, Binhang Wang, Zitao Zhang, Xiang Li, Libo Sun, Guangnan Liu, Yun Tang</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study designed and fabricated an over-reduced Au@CoOx-Co core-shell nanostructure by improving the seed growth process. The Au core promotes the over-reduction of the CoOx-Co shell, and the interfacial interaction introduces oxygen vacancies to provide reaction sites. The Au core generates excitons under light irradiation, which enhances the activation of peroxymonosulfate for degrading fluorine-containing pollutants. This design integrates structural design, photoelectronic regulation, and catalytic enhancement, and has application prospects. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF PHYSICAL CHEMISTRY C</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/81858404/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83158310" class="text-dark hover-underline">Hydrogen-Bonded Mesoporous Frameworks with Tunable Pore Sizes and Architectures from Nanocluster Assembly Units</a> </h4> <p class="text-ellipsis-2">Jie Zhang, LiangLiang Liu, Zaiwang Zhao, Chin-Te Hung, Binhang Wang, Linlin Duan, Kexin Lv, Xiao-Ming Cao, Yun Tang, Dongyuan Zhao</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study reports a micelle-directed nanocluster modular self-assembly approach for the synthesis of two-dimensional hydrogen-bonded mesoporous frameworks (HMFs). The method is based on nanoscale cluster units, which can form uniform hexagonal arrays. By controlling the block lengths and concentrations of the micelles, the size and shape of the mesopores can be precisely controlled. This method is versatile and can be used to synthesize various HMFs with different configurations and compositions. The titanium-oxo cluster-based HMFs show efficient photocatalytic activity for hydrogen evolution, with a conversion rate about 2 times higher than that of the unassembled titanium-oxo clusters. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF THE AMERICAN CHEMICAL SOCIETY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83158310/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Pharmacology & Pharmacy </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27812168" class="text-dark hover-underline">Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin</a> </h4> <p class="text-ellipsis-2">Yong Zhu, Andrey A. A. Sysoev, Paulo H. Jacob Silva, Marine Batista, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> We have reported that CD-6'SLN irreversibly deactivates virions and improves mice survival in H1N1 infection model. CD-6'SLN interacts with the viral envelope protein HA, but not with NA, inhibiting influenza virus through an extracellular mechanism. Our findings suggest that combining viral protein-specific epitopes with hydrophobic linkers provides a strategy for developing antiviral drugs. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PHARMACEUTICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27812168/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Engineering, Biomedical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/33761910" class="text-dark hover-underline">Rehabilitation Modulates High-Order Interactions Among Large-Scale Brain Networks in Subacute Stroke</a> </h4> <p class="text-ellipsis-2">I. Pirovano, Y. Antonacci, A. Mastropietro, C. Bara, L. Sparacino, E. Guanziroli, F. Molteni, M. Tettamanti, L. Faes, G. Rizzo</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> The study investigates interactions among brain networks in subacute stroke patients after motor rehabilitation using electroencephalography signals. The results show an increase in synergy among these networks after rehabilitation, particularly driven by the motor network. Additionally, changes in inter-network connectivity are associated with motor recovery, with the executive control network playing a relevant mediating role. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/33761910/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> <div id="articles_from_journal" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83089996" class="text-dark hover-underline">Development of an FAP-Targeted PET Probe Based on a Novel Quinolinium Molecular Scaffold</a> </h4> <p class="text-ellipsis-2">Lei Li, Rui Cao, Kaixin Chen, Chunrong Qu, Kun Qian, Jia Lin, Renda Li, Chaoquan Lai, Xiao Wang, Zijian Han, Zhijian Xu, Liping Zhou, Shaoli Song, Weiliang Zhu, Zhen Cheng</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study presents a novel radiopharmaceutical, [Ga-68]Ga-SMIC-3002, based on the FAPI ligand SMIC-3002. It demonstrates high in vitro stability and nanomolar affinity for FAP, as well as specific uptake in tumors expressing FAP. The study provides insights into the design of a new generation of FAPI tracers, and [Ga-68]Ga-SMIC-3002 shows great potential for clinical translation. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83089996/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83337755" class="text-dark hover-underline">Discovery Small-Molecule p300 Inhibitors Derived from a Newly Developed Indazolone-Focused DNA-Encoded Library</a> </h4> <p class="text-ellipsis-2">Yanrui Suo, Kaige Li, Xing Ling, Kenian Yan, Weiwei Lu, Jinfeng Yue, Xiaohua Chen, Zhiqiang Duan, Xiaojie Lu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> We developed a DNA-compatible light-promoted reaction for DEL construction. The DEL based on this method can identify novel ligands targeting E1A-binding protein (p300). This study demonstrates the feasibility of light-promoted reactions in DEL synthesis and provides a new idea for developing p300-targeting inhibitors. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83337755/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82950343" class="text-dark hover-underline">Tumor Metabolism: A New Field for the Treatment of Glioma</a> </h4> <p class="text-ellipsis-2">Xiaoqian Chai, Yingjie Zhang, Wen Zhang, Kuanhan Feng, Yingyu Jiang, Anran Zhu, Xiaojin Chen, Liuqing Di, Ruoning Wang</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Glioma treatment is relatively immature, with existing therapies having problems such as drug resistance. Metabolic therapy can change the metabolism of tumor cells, inhibit their growth and spread, be effective for patients insensitive to conventional treatments, and have less impact on normal cells and be safer. The review aims to study the changes in glioma metabolic characteristics and methods, emphasize its metabolic reprogramming pathways and mechanisms, and clarify potential metabolic targets and combination treatment strategies. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82950343/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83568488" class="text-dark hover-underline">Thiol-Specific Linkers for the Synthesis of Oligonucleotide Conjugates via Metal-Free Thiol-Ene Click Reaction</a> </h4> <p class="text-ellipsis-2">Anna L. Malinowska, Harley L. Huynh, Andres F. Correa-Sanchez, Sritama Bose</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This paper presents a novel method for the synthesis of vinylpyrimidine phosphoramidite building blocks for oligonucleotide conjugation, which can be carried out in an automated synthesizer via standard solid-phase synthesis. This new building block can improve the stability and ease of synthesis of oligonucleotides, and can undergo biocompatible conjugation reactions with thiol-functionalized molecules, resulting in the efficient generation of oligonucleotide conjugates. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83568488/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83417470" class="text-dark hover-underline">Lignin-Based Nanoparticles for Combination of Tumor Oxidative Stress Amplification and Reactive Oxygen Species Responsive Drug Release</a> </h4> <p class="text-ellipsis-2">Ziwei Zhou, Jin Wang, Xin Xu, Zhuang Wang, Lingchen Mao, Shanhu Zhang, Huanhuan Zhang, Yuqiang Li, Qingsong Yu, Ni Jiang, Guan Zhang, Zhihua Gan, Zhenbo Ning</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> In this study, a lignin-based copolymer LG-M(TK)-PEG was synthesized, and doxorubicin was attached to its ROS-cleavable bond to prepare a ROS-activatable DOX prodrug LG-M(TK-DOX)-PEG. The prodrug can enhance the uptake of drugs by cancer cells, and lignin can promote the production of ROS in tumor cells, thereby achieving specific activation of the drug and improving the tumor inhibitory effect and biosafety. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83417470/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83144922" class="text-dark hover-underline">Recent Advances in Nanoimmunotherapy by Modulating Tumor-Associated Macrophages for Cancer Therapy</a> </h4> <p class="text-ellipsis-2">Jialei Hao, Xinzhi Zhao, Chun Wang, Xianghui Cao, Yang Liu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Cancer immunotherapy has achieved remarkable results in various tumor types, but the immunosuppressive microenvironment within solid tumors poses significant challenges to established therapies such as immune checkpoint blockade and chimeric antigen receptor T-cell therapy. Tumor-associated macrophages play an important role in tumor growth, and effective regulation of TAMs is crucial to enhancing the efficacy of immunotherapies. Therapeutic strategies targeting TAM modulation have emerged, including blocking TAM recruitment, direct elimination, promoting repolarization to the M1 phenotype, and enhancing phagocytic capacity against tumor cells. The recently introduced CAR macrophage therapy offers new possibilities for macrophage-based immunotherapy. This review focuses on the origin and development of TAMs, their role in promoting tumor growth, and provides an overview of immunotherapies targeting TAMs. It emphasizes the importance of regulating TAMs in enhancing antitumor therapies and discusses the potential and challenges of developing TAMs as targets for immunotherapy. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83144922/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83941728" class="text-dark hover-underline">Linker and Conjugation Site Synergy in Antibody-Drug Conjugates: Impacts on Biological Activity</a> </h4> <p class="text-ellipsis-2">Michihiko Aoyama, Minoru Tada, Hidetomo Yokoo, Takahito Ito, Takashi Misawa, Yosuke Demizu, Akiko Ishii-Watabe</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Antibody-drug conjugates (ADCs) produced by general conjugation methods are heterogeneous, containing mixtures of substances with different numbers of payloads (drug-antibody ratios) conjugated to each antibody and conjugated at multiple sites. This heterogeneity affects the stability, efficacy, and safety of ADCs. Therefore, various site-specific conjugation methods have been developed to achieve homogeneity in ADCs. It has been reported that linker structures and conjugation sites generally affect the properties of site-specific ADCs, such as stability, efficacy, and safety. However, the combined effects of conjugation sites and linker structures on the physicochemical and biological properties of site-specific ADCs remain unclear. In this study, we generated 30 homogeneous site-specific ADCs with a combination of six conjugation sites and five linker structures using THIOMAB technology and evaluated the properties of these homogeneous ADCs. We found that both conjugation sites and linker structures affected the unique properties of ADCs (linker stability and target-dependent and target-independent cytotoxicity). In particular, conjugation to the constant region of the light chain and the presence of polyethylene glycol structures in the linker are important for these ADC-specific properties. Interestingly, we also found that the effects of linker structures on the target-independent cytotoxicity of homogeneous ADCs at certain conjugation sites differed from those seen in conventional heterogeneous ADCs. Our results suggest that optimizing linker structures based on the conjugation site may be necessary for site-specific ADCs. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83941728/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83911466" class="text-dark hover-underline">RPA-CRISPR-Cas-Mediated Dual Lateral Flow Assay for the Point-of-Care Testing of HPV16 and HPV18</a> </h4> <p class="text-ellipsis-2">Kaini Zhang, Qingmei Li, Kun Wang, Qiaoli Zhang, Chengkun Ma, Guiwen Yang, Yanxia Xie, Michael G. Mauk, Shanji Fu, Lei Chen</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This paper introduces a dual lateral flow assay based on RPA-CRISPR-Cas12a/13a (RC-LFA) for HPV detection. The method uses the cleavage specificity of Cas12a and Cas13a to design a CRISPR-Cas12a/Cas13a system for the detection of HPV16 and HPV18. RC-LFA has high specificity and sensitivity (10 copies/μL), and it takes about 40 minutes from nucleic acid extraction to instrument-free readout. The method is user-friendly and instrument-free, making it a promising method for HPV self-tests at home. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83911466/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83417377" class="text-dark hover-underline">Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions</a> </h4> <p class="text-ellipsis-2">Rajamanikkam Kamaraj, Subhrojyoti Ghosh, Souvadra Das, Shinjini Sen, Priyanka Kumar, Madhurima Majumdar, Renesa Dasgupta, Sampurna Mukherjee, Shrimanti Das, Indrilla Ghose, Petr Pavek, Muruga Poopathi Raja Karuppiah, Anil A. Chuturgoon, Krishnan Anand</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> Targeted protein degradation is an emerging treatment that selectively removes disease-causing proteins, showing great potential in preclinical studies and being translated into treating various diseases. The review discusses the latest advances, potential as a new chemical modality for immunotherapy, and innovative applications and research translation of PROTACs, as well as addressing obstacles and prospects in this field. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83417377/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83066051" class="text-dark hover-underline">Oriented Antibody Coupling to an Antifouling Polymer Using Glycan Remodeling for Biosensing by Particle Motion</a> </h4> <p class="text-ellipsis-2">Maud D. M. E. Linssen, Yu-Ting Lin, Sebastian A. H. van den Wildenberg, Marrit M. E. Tholen, Arthur M. de Jong, Menno W. J. Prins</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This paper presents a method for the oriented coupling of antibodies to an antifouling polymer substrate and demonstrates its application in biosensors. The method uses glycan remodeling to create antibody-DNA conjugates, which enables the antibodies to couple in a stable manner while maintaining their conformation and functionality, and to orient the paratope regions outward for good accessibility of analyte molecules in the biofluid. In a sandwich immunosensor for procalcitonin, the glycan-remodeled antibodies showed good biosensing functionality with low nonspecific binding. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83066051/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83100014" class="text-dark hover-underline">Ratiometric Fluorescence Probes for In Situ Imaging of Membrane Tension in Live Cells</a> </h4> <p class="text-ellipsis-2">Hai-Yan Wen, Yusi Hu, You-Yang Duo, Liang Zhao, Zhi-Gang Wang, Shu-Lin Liu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study developed a ratiometric fluorescent probe sensitive to membrane tension, which can be used to quantitatively measure the changes in membrane tension after cells are stimulated. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83100014/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83463209" class="text-dark hover-underline">Chemical Synthesis of Interleukin-6 for Mirror-Image Screening</a> </h4> <p class="text-ellipsis-2">Keisuke Aoki, Kayuu Maeda, Shinsuke Inuki, Hiroaki Ohno, Motohiro Nonaka, Shinya Oishi</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study chemically synthesized IL-6 and its enantiomer d-IL-6 using a sequential N-to-C native chemical ligation strategy, and demonstrated their similar structural and binding properties. Functional d-IL-6 was used to screen an antibody fragment library, identifying d-IL-6-binding single-domain antibodies. This work contributes to the development of novel and potent IL-6 inhibitors. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83463209/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83555459" class="text-dark hover-underline">Biocatalytic Clusterzyme Patches Restore Lung Function via Immunomodulation and Mitochondria Protection</a> </h4> <p class="text-ellipsis-2">Wei Liu, Sufei Zhou, Ke Yang, Di Liu, Yuxing Yan, Fangzhen Tian, Tianyi Cui, Wei Wang, Lewei Bi, Lan Li, Hao Wang, Xiao-Dong Zhang</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This study presents a functionalized patch that acts on the lung airways and repairs the injured organ via clusterzymes. The patch has long-term antioxidant capacity, can improve lung function impairment, reduce inflammatory factors, increase mitochondrial DNA copy number and ATP production, and significantly improve mouse lung function. This patch provides a new avenue for effective intervention of lung injury. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83555459/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83024506" class="text-dark hover-underline">Photoinduced Charge Centralization Quenches the Fluorescence of Conjugation-Fused Tetrazine Labels with Red-to-Near-Infrared Emissions</a> </h4> <p class="text-ellipsis-2">Tianruo Shen, Xiaogang Liu</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This paper discusses the application of tetrazine-derived fluorogenic labels in biological and medical imaging, emphasizes the importance of the photoinduced charge centralization (PCC) mechanism in fluorescence quenching, and proposes two molecular design strategies based on the PCC mechanism and structural isomerization to develop high-performance tetrazine-based labels, promoting the development of multiplex fluorescence imaging techniques. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83024506/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83199291" class="text-dark hover-underline">Sortase-Mediated Site-Specific Conjugation to Prepare Fluorine-18-Labeled Nanobodies</a> </h4> <p class="text-ellipsis-2">Falguni Basuli, Jianfeng Shi, Eric Lindberg, Stanley Fayn, Woonghee Lee, Mitchell Ho, Dima A. Hammoud, Ross W. Cheloha, Rolf E. Swenson, Freddy E. Escorcia</p> <div class="d-flex mb-3"> <div class="p-3 rounded" style="background-color: #e8f3ff;"> <strong>Summary:</strong> This paper presents a novel sortase-based, site-specific F-18-labeling method for three nanobodies. The method is simple, reproducible, and generalizable, and the labeled nanobodies have high radiochemical purity and stability, which can be used in preclinical and clinical studies. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOCONJUGATE CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83199291/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="modal fade" id="export-citation" tabindex="-1"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal"><span>×</span></button> <h4 class="modal-title">导出引文 <b class="text-primary"></b></h4> </div> <div class="modal-body"> <div class="my-3 px-4 f16"> <form action="https://www.peeref.com/zh/works/citation/download" 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