CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="120"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "publications.waset.org",cType: 'non-interactive',cRay: '91357c99ea42fd96',cH: 'KuimGcoil6bAGUQvnotFX.EgKHi_X_BPcwtEty88is0-1739792260-1.2.1.1-38z9zNY7K93b4ZBfmlHGZL9nYOJ1VNSvvRjnqyL__Z.QOk3omW_CeN9lWT89D2NC',cUPMDTk: "\/abstracts\/search?q=pharmaceutical&__cf_chl_tk=k3vsaBhT8itsxOsQvu4x53J35IPA5MXlGVV188i2RKo-1739792260-1.0.1.1-JPcFiBKzqJ84P3vLg2UuqrSJlYQftAsRI8mvZWjVUtc",cFPWv: 'b',cITimeS: '1739792260',cTTimeMs: '1000',cMTimeMs: '120000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/abstracts\/search?q=pharmaceutical&__cf_chl_f_tk=k3vsaBhT8itsxOsQvu4x53J35IPA5MXlGVV188i2RKo-1739792260-1.0.1.1-JPcFiBKzqJ84P3vLg2UuqrSJlYQftAsRI8mvZWjVUtc",md: "K07TFKWNz73aYONYuL39UDBdJqp.tMnVr3X8DyELRK0-1739792260-1.2.1.1-YfEZ8wXic5yDU9Ktl3PuPJRdmlsmqvf3wJz7cIAMe1FdkLkIq8mlYh8E2gAceMiD7x1TZJgfzJb3sCbwBiwi.gmCCorKPYQ.VYrXLvrzaBazzj5JJc9995zZKh4MAKquLDR5Qi__zPuLJxj1PIpGYUkC_mjKuOG7Eb6BupuwAKqQ_vpFcj.TEVDLrhwkcEBESlnyP.PfkpAkX7S.zrFZlC8Bq1G6L8QRb5hpo8cXhubSIr4dSrWMNi29W1ggnY3_RIS0.OvxGP42JMXmgnGkqf0l4VT4.5kt8DOhbCi8oB2lupmG2kQ9Kn0BSHB7ktplTwlHTb.YBwiDqa358kus9ZwsOEmvNXu.tAkMyF07jMYRAPLlS4O80g2yybMAMDhXsQVU0nCYL9_FlRRbALWT94wJvYuDanwfZXF52O0xebaKk_wRZ4niet7odqqLO75010gtB.W35XGkLrF4mSXyQ.nT4U0kv_wdRLYTChydmLUNablOyUCb9N61eRmL0ACIU5bxtFM4irb2GjYuN6iQrFIfjDyjj0vC14pdVB9vlI.rdn9uNGOHjrxqXAthjrXX4cz1WQl1arQ4dLTE2p3abWL.ylb8wE9igsJmwYJixN132Nh.e07VaDSc1BSIS2maLGbt5wqzjM3mjKiSl7SEsGAStcN.8hRHQyFClwXkJqnEXkXweOs9XpdIDNaFDca9pzfmngJR4VmMrtTlB.sC577ch7BWkwl5kl4kJlPFGLq7rQspciqgfVMhiB_VNOLGOdANJsbg6DrhC8KdW_Lh_tx.w8VyKccvCEw1sT7bF2ed3FgM7_2e9VGT0nOi_tSUzKfMbAPCV5e4VEu6HR.5KHWWE2LuCPhqr1NraLLYIQXfUU0dNr0pliQVhzGnxExf_SUE5G.rgN4ohRTSfdv3NmesqbmhuY7VilxkXW9NXpbUCkuUseXa62YB86kPmt2.QBee7FLDJLWtcq__p6avkn88UzSM2pEfdpa7AXG6y8erIFDocU5Uj3O1Xx4gRceBqzZGH0DOAQ2zoPzELVOytRLDws.AjQKkchH3_gd2WBmZa745f0spfmkoD27IDU6MA17j7p8j5yMdmfl6zBNT9wxSvQgZT5BjPiku00YPQpNLxJyM_P5AetkljOkkqHp9Si17U_TUjDc623OEJ_IkhSVqofZEHVG006H4gC6fFP0LNBrJMudcUdEVL0OGOq2VCNFu5ZXAlu145oSuWsvei9b_DTSvLikS6l2PnfFf_yFYbuHH.IilnZxkU6U_j3WiJl6BopVu9Mlex2.oSfsxRgR5lTBdyVebQdg80a6yvKmSRfv12Tai.J1LTOnBHrv1FtR_4s4u.00uE_wXYB15DIsaoYDaR5eHePuo7FdtnReHIx7QlThU69r9s7gBHBy58rmXj6SMnz9CKOHqXAuWblbit.U8duR9hVu_qe_kLKSXRnQiP.eH1OH.dp6hEwajFcREHzUCI9u9ucWnE_fFMX2hms9owkFVCaVrHqlQBL7r6kASUa81B4LBMMQoNgeHX4Ld53AggYiUV1A.eq189p2nHvSy0zLkOfWH4aekuiPN5dtMbfZwV0SuzT4mteBi14XlfE7RRb9G0ITz0XEHm6Rz2_gi4psdhNdzdTTNqIt5onNmsNFMI8CGAqdrc1rKF9oQLCdBarlA2Qg24wi1U2UReLhpzGGUvOQdMMG10zSmb8V.ZBKRPfOjkjGbLuej.Q7H.DS1icDr4KhooFHi3rxP3W.ZWXqmkHfBu5ZNd8.mjooZp50J7L._Y1ymExuLGbK_yRLFK7xabypchEe4CAXuVDJdOx4ZFQKGLvcS8caKwhv6u.OVER5mSpMz_ATbjY1LV6wCna8DmMH0sk.CR9FVVeVfM.v_hFDQ_sLA7_GfjRQFe06n8t0sgIJk6JVTMaSS2yNzE8DzpCzdWksQeFaTa_TY9qt6ybrsaDh88mk",mdrd: "vvCX2QMmac0M1kb8alElYNjx40hJcOwrj9PfD0oa2YQ-1739792260-1.2.1.1-_BCVD9mhksoVE.6zTSPXLy5uE5aFbpy2ZV9BzjrZPJPu6i8mbwkM4Q88mTgHF0DZ.1gHBLIi_mihZt0oSXCWOKg95OOIWT4snLIwPwkrtIW730bckYh7r2zgI0se6A.oQyUoNEN6j.HOLZzMNGVuyz.eSUfrKQr1sAORZM4wD94xh6f.NQ0MnDcjpJHYvW3ZDU4rkTWJXNOFnhCYKIpFsAwegSAvvRxUxVzGeqvDzcFsnBxEQNZoMKrdDZvBbIBsoXOeAgJbeRIdOIQ2PA.1AhekS2DxRnNv0Z46vrz8I8SPxwjBR0GnBInGvMC1N29mRoA64uFdUJMjkh8nlM6iHmqo7a9AjnnABTTr683L7Is0SHCq0Mpu0i1H1.xyhyA8kj_Suosnbz8DkH31WSktZJAYUUbAIu1LKMDYFjzgo2yuALDRjxxqP3s9zA_J_h2Fw7rGIXpukFBPzol_p9aO21GgkENrSzlbYD9Mv0PbPzFzra4xNcMkxdi_qgA6QQascGU363srMj6jhTkPKq7VbUoMeBaQxTYab8bV9GO9TlVoTGI2s1jK1qZk7tliR5GcOAYRCNn2CRZwXvgRhoelLxI7p_c9ua4GxcyxgmXgifRin_Fcre1sGK__OgzcOd5P9fSOW_IoIXjXMjnTSAYhNFztJWfa4fyMESkC0XjegT2jTEtuoPAhssmbOzDYSuUFot02F2reNIshC9f.eU9mYyM1ObuAL6heD7LB1dOnZyxPQB30eFECP2RiMddJy5.9.OUxTLyStFnKln.cYBcRTUajfM7oqx5JnJPXIv6LGcEu0Mc0tcpO.RoJh.QLQuPSTOrDtfl5ZeGEYx_OGMzn2lreGiAnb1dA._wZYnUk44Mr1uaYtVeYq6eP5PEykctqWbbK7iTehzgXUSZSJQ8iIil6XxZ__YyTNfDla207hCsOYG5YswtYEJWZx.SJ2mCFRNehyexGLTiaPY9OxS8QHeKVLeRmPvSUC5.yjhzBnUQSJAXmHTlEU2PAiaCVLZfCx_fyrsvy7Bp1P1_WaL7lXhA3Jf_eTT8MY3VuP4yBeO80UTCmiqLVzQN0lCMWS5WyrdruMgcrtrQk6TBaPzudhPU3MMwC0K8jzBTSaGNCGbUtQGquvLyt6S7QtRxHDxXOdXs9bjc54kAdAbYyQghZLAxlKVMwsUdrbygykBPOmfXt1uo_ybTK05.BUmvBHXrQQIsNgj_sSIkVEGoDIPNY3oF0tweyA9diAfSoEAVg0m3g7O6nCi..6n9TPkOsDwDeWTjpoyxwiWFfwtkK2.GSZ2IKbPxrpmKb5XKg3pR4yDu_qtGYrGhlzUfrswZwWu2IUVUkvik68CmH6dK1SPuUD.ieKgCdcvTr0bmdOFuRrcfdsSkjgWSOqkyHY6wFxFSuRzXU14sU9o5Cau7_NtBzH1nbeJAzpYO70izHL_4fho_AOHwtAH3Xm7fYei_.Xusy5PNmgM2CGZ88ImqONP89avcH4GInx4RbTOGmis0QuqJ.WbJ.hfEr0l9tp51VHEJymZCTIt_BPSDAStN9qjlnfquW8ySF2BdpmF3QLhyYC8chWOek5quVreTZogJjkbYWElz8p9dQTSXHI4bsSVz4L8U9SoIzVy5yXwf6Nnq3PGsGIxyB3q_b.PFLz5N2MOk_Lx9nRCYPukIdwv..hp.kthYrpNhArsQSVmmWG25fDwJ_I85CzkXvcTjhiQBJvlg9VdNKmVgRn_hQWOquxSDvp7uu8uo9mmd_8pPqN78cC45XVesKAh1pialaLnVYxxynJ5sBILi8RcrYQcuRU4OVInZzKLbUptBojU5yOsTqhLOHG2DDLjLSXNvaeiLzaFyKx7GRh8axhqXOEJbjZ11V2_DELWwuUjWFsnwcAEBiYWZhSDDYiUEtdHjMBvyyVsyKYcmoK7gha_ahOxGYe58L4zoRYkjUHmymuStt5pvMgI.EHcdzrYkSx_oIYvGNpcFe"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=91357c99ea42fd96';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/abstracts\/search?q=pharmaceutical&__cf_chl_rt_tk=k3vsaBhT8itsxOsQvu4x53J35IPA5MXlGVV188i2RKo-1739792260-1.0.1.1-JPcFiBKzqJ84P3vLg2UuqrSJlYQftAsRI8mvZWjVUtc" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>