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$viewedUser = Aedu.User.set_viewed( {"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/RoxySenior","location":"/RoxySenior","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/RoxySenior","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-fe71e76c-dd16-4271-8e61-a15c42f951c0"></div> <div id="ProfileCheckPaperUpdate-react-component-fe71e76c-dd16-4271-8e61-a15c42f951c0"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Roxy Senior</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div 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src="https://attachments.academia-assets.com/119638429/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125631063/Coronary_Microvascular_Dysfunction_in_Patients_with_Chest_Pain_and_Unobstructed_Coronary_Arteries_Influence_of_Systemic_Inflammation_Plaque_Burden_and_Morphology">Coronary Microvascular Dysfunction in Patients with Chest Pain and Unobstructed Coronary Arteries: Influence of Systemic Inflammation, Plaque Burden and Morphology</a></div><div class="wp-workCard_item"><span>Heart Lung and Circulation</span><span>, Aug 1, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a3d5f6bc9f4817a2b11186e5cc74922e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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data-work-id="125630965"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125630965/Sex_Differences_in_Stress_Test_and_Ccta_Findings_and_Symptoms_in_the_Randomized_Ischemia_Trial"><img alt="Research paper thumbnail of Sex Differences in Stress Test and Ccta Findings and Symptoms in the Randomized Ischemia Trial" class="work-thumbnail" src="https://attachments.academia-assets.com/119638386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125630965/Sex_Differences_in_Stress_Test_and_Ccta_Findings_and_Symptoms_in_the_Randomized_Ischemia_Trial">Sex Differences in Stress Test and Ccta Findings and Symptoms in the Randomized Ischemia Trial</a></div><div 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121924417/Initial_Invasive_or_Conservative_Strategy_for_Stable_Coronary_Disease">Initial Invasive or Conservative Strategy for Stable Coronary Disease</a></div><div class="wp-workCard_item"><span>New England Journal of Medicine</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a7b67bdfaab2922982a0d2e1e3e27b56" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116692142,"asset_id":121924417,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116692142/download_file?st=MTczMjc1MzI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action 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METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasivestrategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, −1.8 percentage points; 95% CI, −4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. 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src="https://attachments.academia-assets.com/112328589/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116106479/Baseline_Characteristics_and_Risk_Profiles_of_Participants_in_the_ISCHEMIA_Randomized_Clinical_Trial">Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial</a></div><div class="wp-workCard_item"><span>JAMA Cardiology</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="68f036ab1971c940df1fd854609b58d9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112328589,"asset_id":116106479,"asset_type":"Work","button_location":"profile"}" 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "68f036ab1971c940df1fd854609b58d9" } } $('.js-work-strip[data-work-id=116106479]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116106479,"title":"Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial","translated_title":"","metadata":{"publisher":"American Medical Association (AMA)","grobid_abstract":"It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. OBJECTIVE To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. DESIGN, SETTING, AND PARTICIPANTS The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (\u003c50% for imaging stress test and \u003c70% for ETT). The study included 341 enrolling sites (320 randomizing) in 38 countries and patients with SIHD and moderate or severe ischemia on stress testing. Data presented were extracted on December 17, 2018. MAIN OUTCOMES AND MEASURES Enrolled, excluded, and randomized participants' baseline characteristics. No clinical outcomes are reported. RESULTS A total of 8518 patients were enrolled, and 5179 were randomized. Common reasons for exclusion were core laboratory determination of insufficient ischemia, unprotected left main stenosis of at least 50%, or no stenosis that met study obstructive CAD criteria on study coronary computed tomography angiography. Randomized participants had a median age of 64 years, with 1168 women (22.6%), 1726 nonwhite participants (33.7%), 748 Hispanic participants (15.5%), 2122 with diabetes (41.0%), and 4643 with a history of angina (89.7%). Among the 3909 participants randomized after stress imaging, core laboratory assessment of ischemia severity (in 3901 participants) was severe in 1748 (44.8%), moderate in 1600 (41.0%), mild in 317 (8.1%) and none or uninterpretable in 236 (6.0%), Among the 1270 participants who were randomized after nonimaging ETT, core laboratory determination of ischemia severity (in 1266 participants) was severe (an eligibility criterion) in 1051 (83.0%), moderate in 101 (8.0%), mild in 34 (2.7%) and none or uninterpretable in 80 (6.3%). Among the 3912 of 5179 randomized participants who underwent coronary computed tomography angiography, 79.0% had multivessel CAD (n = 2679 of 3390) and 86.8% had left anterior descending (LAD) stenosis (n = 3190 of 3677) (proximal in 46.8% [n = 1749 of 3739]). Participants undergoing ETT had greater frequency of 3-vessel CAD, LAD, and proximal LAD stenosis than participants undergoing stress imaging. CONCLUSIONS AND RELEVANCE The ISCHEMIA trial randomized an SIHD population with moderate or severe ischemia on stress testing, of whom most had multivessel CAD.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"JAMA 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113292495/Association_of_Sex_With_Severity_of_Coronary_Artery_Disease_Ischemia_and_Symptom_Burden_in_Patients_With_Moderate_or_Severe_Ischemia"><img alt="Research paper thumbnail of Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia" class="work-thumbnail" src="https://attachments.academia-assets.com/110289537/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113292495/Association_of_Sex_With_Severity_of_Coronary_Artery_Disease_Ischemia_and_Symptom_Burden_in_Patients_With_Moderate_or_Severe_Ischemia">Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia</a></div><div class="wp-workCard_item"><span>JAMA Cardiology</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d40bdd88cccc5d3d53ece52e69ec722" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110289537,"asset_id":113292495,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110289537/download_file?st=MTczMjc1MzI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113292495"><a class="js-profile-work-strip-edit-button" 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$('.js-work-strip[data-work-id=113292495]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113292495,"title":"Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia","translated_title":"","metadata":{"publisher":"American Medical Association (AMA)","grobid_abstract":"; for the ISCHEMIA Research Group IMPORTANCE While many features of stable ischemic heart disease vary by sex, differences in ischemia, coronary anatomy, and symptoms by sex have not been investigated among patients with moderate or severe ischemia. The enrolled ISCHEMIA trial cohort that underwent coronary computed tomographic angiography (CCTA) was required to have obstructive coronary artery disease (CAD) for randomization. OBJECTIVE To describe sex differences in stress testing, CCTA findings, and symptoms in ISCHEMIA trial participants. DESIGN, SETTING, AND PARTICIPANTS This secondary analysis of the multicenter ISCHEMIA randomized clinical trial analyzed baseline characteristics of patients with stable ischemic heart disease. Individuals were enrolled from July 2012 to January 2018 based on local reading of moderate or severe ischemia on a stress test, after which blinded CCTA was performed in most. Core laboratories reviewed stress tests and CCTAs. Participants with no obstructive CAD or with left main CAD of 50% or greater were excluded. Those who met eligibility criteria including CCTA (if performed) were randomized to a routine invasive or a conservative management strategy (N = 5179). Angina was assessed using the Seattle Angina Questionnaire. Analysis began October 1, 2018. INTERVENTIONS CCTA and angina assessment. MAIN OUTCOMES AND MEASURES Sex differences in stress test, CCTA findings, and symptom severity. RESULTS Of 8518 patients enrolled, 6256 (77%) were men. Women were more likely to have no obstructive CAD (\u003c50% stenosis in all vessels on CCTA) (352 of 1022 [34.4%] vs 378 of 3353 [11.3%]). Of individuals who were randomized, women had more angina at baseline than men (median [interquartile range] Seattle Angina Questionnaire Angina Frequency score: 80 [70-100] vs 90 [70-100]). Women had less severe ischemia on stress imaging (383 of 919 [41.7%] vs 1363 of 2972 [45.9%] with severe ischemia; 386 of 919 [42.0%] vs 1215 of 2972 [40.9%] with moderate ischemia; and 150 of 919 [16.3%] vs 394 of 2972 [13.3%] with mild or no ischemia). Ischemia was similar by sex on exercise tolerance testing. Women had less extensive CAD on CCTA (205 of 568 women [36%] vs 1142 of 2418 men [47%] with 3-vessel disease; 184 of 568 women [32%] vs 754 of 2418 men [31%] with 2-vessel disease; and 178 of 568 women [31%] vs 519 of 2418 men [22%] with 1-vessel disease). Female sex was independently associated with greater angina frequency (odds ratio, 1.41; 95% CI, 1.13-1.76). CONCLUSIONS AND RELEVANCE Women in the ISCHEMIA trial had more frequent angina, independent of less extensive CAD, and less severe ischemia than men. These findings reflect inherent sex differences in the complex relationships between angina, atherosclerosis, and ischemia that may have implications for testing and treatment of patients with suspected stable ischemic heart disease.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"JAMA 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data-work-id="102764778"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102764778/Corrigendum_to_The_clinical_applications_of_myocardial_contrast_echocardiography_Eur_J_Echocardiogr_2007_8_S24_S29_"><img alt="Research paper thumbnail of Corrigendum to “The clinical applications of myocardial contrast echocardiography” [Eur J Echocardiogr 2007;8:S24–S29]" class="work-thumbnail" src="https://attachments.academia-assets.com/102947542/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102764778/Corrigendum_to_The_clinical_applications_of_myocardial_contrast_echocardiography_Eur_J_Echocardiogr_2007_8_S24_S29_">Corrigendum to “The clinical applications of myocardial contrast echocardiography” [Eur J Echocardiogr 2007;8:S24–S29]</a></div><div class="wp-workCard_item"><span>European Journal of Echocardiography</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2ddfe582b747f18246e0c1a23d9fa148" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102947542,"asset_id":102764778,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102947542/download_file?st=MTczMjc1MzI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102764778"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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href="https://www.academia.edu/102764754/Comparative_Effectiveness_of_Exercise_Electrocardiography_versus_Exercise_Echocardiography_in_Women_Presenting_with_Suspected_Coronary_Artery_Disease_A_Randomised_Study"><img alt="Research paper thumbnail of Comparative Effectiveness of Exercise Electrocardiography versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study" class="work-thumbnail" src="https://attachments.academia-assets.com/102947504/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102764754/Comparative_Effectiveness_of_Exercise_Electrocardiography_versus_Exercise_Echocardiography_in_Women_Presenting_with_Suspected_Coronary_Artery_Disease_A_Randomised_Study">Comparative Effectiveness of Exercise Electrocardiography versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study</a></div><div class="wp-workCard_item"><span>European Heart Journal Open</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective There is a paucity of randomised diagnostic studies in women with suspected coronary ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective There is a paucity of randomised diagnostic studies in women with suspected coronary artery disease(CAD). This study sought to assess the relative value of exercise stress echocardiography (ESE) compared with exercise ECG (Ex-ECG) in women with CAD. Methods Accordingly, 416 women with no prior CAD and intermediate probability of CAD (mean pre-test probability 41%), were randomized to undergo either Ex-ECG or ESE. The primary endpoints were the positive predictive value (PPV) for the detection of significant CAD and downstream resource utilisation. Results The PPV of ESE and Ex-ECG were 33% and 30% (p = 0.87) respectively for the detection of CAD. There were similar clinic visits (36 vs 29, p = 0.44) and emergency visits with chest pain (28 vs 25, p = 0.55) in the Ex-ECG and ESE arms respectively. At 2.9 years,cardiac events were 6 Ex-ECG vs 3 ESE, p = 0.31. Although initial diagnosis costs were higher for ESE, more women underwent further CAD testing in the Ex-ECG arm comp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b81d60d8cabd643c788e8da0124904b0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102947504,"asset_id":102764754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102947504/download_file?st=MTczMjc1MzI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102764754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102764754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102764754; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102764754]").text(description); $(".js-view-count[data-work-id=102764754]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102764754; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102764754']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102764754, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b81d60d8cabd643c788e8da0124904b0" } } $('.js-work-strip[data-work-id=102764754]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102764754,"title":"Comparative Effectiveness of Exercise Electrocardiography versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study","translated_title":"","metadata":{"abstract":"Objective There is a paucity of randomised diagnostic studies in women with suspected coronary artery disease(CAD). 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Although initial diagnosis costs were higher for ESE, more women underwent further CAD testing in the Ex-ECG arm comp...","publisher":"Oxford University Press (OUP)","publication_name":"European Heart Journal Open"},"translated_abstract":"Objective There is a paucity of randomised diagnostic studies in women with suspected coronary artery disease(CAD). This study sought to assess the relative value of exercise stress echocardiography (ESE) compared with exercise ECG (Ex-ECG) in women with CAD. Methods Accordingly, 416 women with no prior CAD and intermediate probability of CAD (mean pre-test probability 41%), were randomized to undergo either Ex-ECG or ESE. The primary endpoints were the positive predictive value (PPV) for the detection of significant CAD and downstream resource utilisation. Results The PPV of ESE and Ex-ECG were 33% and 30% (p = 0.87) respectively for the detection of CAD. There were similar clinic visits (36 vs 29, p = 0.44) and emergency visits with chest pain (28 vs 25, p = 0.55) in the Ex-ECG and ESE arms respectively. At 2.9 years,cardiac events were 6 Ex-ECG vs 3 ESE, p = 0.31. Although initial diagnosis costs were higher for ESE, more women underwent further CAD testing in the Ex-ECG arm comp...","internal_url":"https://www.academia.edu/102764754/Comparative_Effectiveness_of_Exercise_Electrocardiography_versus_Exercise_Echocardiography_in_Women_Presenting_with_Suspected_Coronary_Artery_Disease_A_Randomised_Study","translated_internal_url":"","created_at":"2023-06-02T12:58:14.871-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102947504,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102947504/thumbnails/1.jpg","file_name":"oead053.pdf","download_url":"https://www.academia.edu/attachments/102947504/download_file?st=MTczMjc1MzI2NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparative_Effectiveness_of_Exercise_El.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102947504/oead053-libre.pdf?1685737267=\u0026response-content-disposition=attachment%3B+filename%3DComparative_Effectiveness_of_Exercise_El.pdf\u0026Expires=1732728429\u0026Signature=BWgz2NUwIoncBmu-ty~sqLxRM95fBlEhXoGsSSIi55Gqow7oGraWEAP8UchHSCA0hCwlqAgMiV-l6EsT1Pt7ZRbu4qnFTd7tPgBY6eMRNNXQ51UQaZxzD98mK7JKfhw6JAkJ3Jg-RvywF295TUTxj7F4Omlq-RVjQTVWJH9Sj5PoCdfyxtgg3j19OObQJgCP6ND3B7ctVevlAUlNWAffKSCIMRQv5bYPJkYMyMHi-m~kvwCZ6eSfh-~Nn65s6j4NiEuUuQ5kMID8g8k8w2eavFswzEhe1l8OMkBvbR69gBYlB3FG7ro6plTQ808w8ZxLsMfAcPA96K3xpXduKzlxvw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparative_Effectiveness_of_Exercise_Electrocardiography_versus_Exercise_Echocardiography_in_Women_Presenting_with_Suspected_Coronary_Artery_Disease_A_Randomised_Study","translated_slug":"","page_count":36,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":102947504,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102947504/thumbnails/1.jpg","file_name":"oead053.pdf","download_url":"https://www.academia.edu/attachments/102947504/download_file?st=MTczMjc1MzI2NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparative_Effectiveness_of_Exercise_El.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102947504/oead053-libre.pdf?1685737267=\u0026response-content-disposition=attachment%3B+filename%3DComparative_Effectiveness_of_Exercise_El.pdf\u0026Expires=1732728429\u0026Signature=BWgz2NUwIoncBmu-ty~sqLxRM95fBlEhXoGsSSIi55Gqow7oGraWEAP8UchHSCA0hCwlqAgMiV-l6EsT1Pt7ZRbu4qnFTd7tPgBY6eMRNNXQ51UQaZxzD98mK7JKfhw6JAkJ3Jg-RvywF295TUTxj7F4Omlq-RVjQTVWJH9Sj5PoCdfyxtgg3j19OObQJgCP6ND3B7ctVevlAUlNWAffKSCIMRQv5bYPJkYMyMHi-m~kvwCZ6eSfh-~Nn65s6j4NiEuUuQ5kMID8g8k8w2eavFswzEhe1l8OMkBvbR69gBYlB3FG7ro6plTQ808w8ZxLsMfAcPA96K3xpXduKzlxvw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":102947503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102947503/thumbnails/1.jpg","file_name":"oead053.pdf","download_url":"https://www.academia.edu/attachments/102947503/download_file","bulk_download_file_name":"Comparative_Effectiveness_of_Exercise_El.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102947503/oead053-libre.pdf?1685737270=\u0026response-content-disposition=attachment%3B+filename%3DComparative_Effectiveness_of_Exercise_El.pdf\u0026Expires=1732728429\u0026Signature=B8NKeI2m2Umouo7mdCPlWQvV4IrmktO3lNrQVZCy8Na8VjVMlSZH4Wx4UbLFKlj6~04GCFrlod7AfhrVCmK0ZAbdKdn5mSgH3NwFeZW7prc1WvcuUT~R639q9IkWmmUA8ohf85xR3hsPDeGApoJGiCqMauER1QcfDcu3ALETGFx5yzMCUwaz0uuOerG1BVgJwRwvz52Nhp2E7Ps-4vZIq6rP-47QMl1Yv8ambyeeSzOQxQvH9odwGmZD3mtwap72NQTws7Hprg3Y639psuNYZyLj4hgvODlAhI-Jkqpa1uUg5EGSVfBt50rJSlvqa26kNAN3LHKam725cpIbI6BU8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":31958750,"url":"https://academic.oup.com/ehjopen/advance-article-pdf/doi/10.1093/ehjopen/oead053/50417493/oead053.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94140671"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94140671/Ultrasound_contrast_agent_hypersensitivity_in_patients_allergic_to_polyethylene_glycol_position_statement_by_the_European_Association_of_Cardiovascular_Imaging"><img alt="Research paper thumbnail of Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging" class="work-thumbnail" src="https://attachments.academia-assets.com/96681446/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94140671/Ultrasound_contrast_agent_hypersensitivity_in_patients_allergic_to_polyethylene_glycol_position_statement_by_the_European_Association_of_Cardiovascular_Imaging">Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging</a></div><div class="wp-workCard_item"><span>European Heart Journal - Cardiovascular Imaging</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Food and Drug Administration alert enhances our understanding of the mechanism of severe reac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Food and Drug Administration alert enhances our understanding of the mechanism of severe reactions to ultrasound-enhancing agents (UEAs). The known incidence of these reactions remains low and unchanged (1 in 10 000 administrations). Because the risk-to-benefit ratio for ultrasound contrast agents (UCAs) remains extremely low, we do not advise any changes to laboratory policy regarding indications for their use. The use of these agents should continue in situations where they have been shown to be impactful. Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, to polyethylene glycol (PEG) (macrogol), or to PEG-containing products, such as certain bowel preps for colonoscopy or laxatives.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f03c7c666e1f5bfb44ffb62c18d55df3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":96681446,"asset_id":94140671,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/96681446/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94140671"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94140671"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94140671; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94140671]").text(description); $(".js-view-count[data-work-id=94140671]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94140671; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94140671']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94140671, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f03c7c666e1f5bfb44ffb62c18d55df3" } } $('.js-work-strip[data-work-id=94140671]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94140671,"title":"Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging","translated_title":"","metadata":{"abstract":"The Food and Drug Administration alert enhances our understanding of the mechanism of severe reactions to ultrasound-enhancing agents (UEAs). The known incidence of these reactions remains low and unchanged (1 in 10 000 administrations). Because the risk-to-benefit ratio for ultrasound contrast agents (UCAs) remains extremely low, we do not advise any changes to laboratory policy regarding indications for their use. The use of these agents should continue in situations where they have been shown to be impactful. Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, to polyethylene glycol (PEG) (macrogol), or to PEG-containing products, such as certain bowel preps for colonoscopy or laxatives.","publisher":"Oxford University Press (OUP)","publication_name":"European Heart Journal - Cardiovascular Imaging"},"translated_abstract":"The Food and Drug Administration alert enhances our understanding of the mechanism of severe reactions to ultrasound-enhancing agents (UEAs). The known incidence of these reactions remains low and unchanged (1 in 10 000 administrations). Because the risk-to-benefit ratio for ultrasound contrast agents (UCAs) remains extremely low, we do not advise any changes to laboratory policy regarding indications for their use. The use of these agents should continue in situations where they have been shown to be impactful. Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, to polyethylene glycol (PEG) (macrogol), or to PEG-containing products, such as certain bowel preps for colonoscopy or laxatives.","internal_url":"https://www.academia.edu/94140671/Ultrasound_contrast_agent_hypersensitivity_in_patients_allergic_to_polyethylene_glycol_position_statement_by_the_European_Association_of_Cardiovascular_Imaging","translated_internal_url":"","created_at":"2023-01-02T00:58:41.476-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":96681446,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/96681446/thumbnails/1.jpg","file_name":"jeab120.pdf","download_url":"https://www.academia.edu/attachments/96681446/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ultrasound_contrast_agent_hypersensitivi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/96681446/jeab120-libre.pdf?1672660810=\u0026response-content-disposition=attachment%3B+filename%3DUltrasound_contrast_agent_hypersensitivi.pdf\u0026Expires=1732756866\u0026Signature=LPu1~wScEaPy9oxSU~FtIx6YotkQIr1moI0LmnQ0AZ8o11PIDiQEco6ECg7-r-jozxot2RtgpVHRILBYTGeeZjPMFkAyA7rqOgVmirDEJCxpA-XyOKrCGkmAlvBLImiYmXu0BQJkw0TaKLRrt~RwhCnGlvvu7oGmXDwINfXr6cS6J-72lSTxsnY8Ljzh0vvoSa4AF-WYACH4iQQ8xjvmdJkq1NYvOJ26EpPTWV8iL4sI9GwBREp78aYX7~WZO3AOX0xSCToqKshh2EBlnvxRCbw-GahnGVzVu4NmJoqjUZc~nZ5fhQ34pAHV9u0EzxV3CY0zE0-SF6a~v2FGGaxDxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Ultrasound_contrast_agent_hypersensitivity_in_patients_allergic_to_polyethylene_glycol_position_statement_by_the_European_Association_of_Cardiovascular_Imaging","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":96681446,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/96681446/thumbnails/1.jpg","file_name":"jeab120.pdf","download_url":"https://www.academia.edu/attachments/96681446/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ultrasound_contrast_agent_hypersensitivi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/96681446/jeab120-libre.pdf?1672660810=\u0026response-content-disposition=attachment%3B+filename%3DUltrasound_contrast_agent_hypersensitivi.pdf\u0026Expires=1732756866\u0026Signature=LPu1~wScEaPy9oxSU~FtIx6YotkQIr1moI0LmnQ0AZ8o11PIDiQEco6ECg7-r-jozxot2RtgpVHRILBYTGeeZjPMFkAyA7rqOgVmirDEJCxpA-XyOKrCGkmAlvBLImiYmXu0BQJkw0TaKLRrt~RwhCnGlvvu7oGmXDwINfXr6cS6J-72lSTxsnY8Ljzh0vvoSa4AF-WYACH4iQQ8xjvmdJkq1NYvOJ26EpPTWV8iL4sI9GwBREp78aYX7~WZO3AOX0xSCToqKshh2EBlnvxRCbw-GahnGVzVu4NmJoqjUZc~nZ5fhQ34pAHV9u0EzxV3CY0zE0-SF6a~v2FGGaxDxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":96681445,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/96681445/thumbnails/1.jpg","file_name":"jeab120.pdf","download_url":"https://www.academia.edu/attachments/96681445/download_file","bulk_download_file_name":"Ultrasound_contrast_agent_hypersensitivi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/96681445/jeab120-libre.pdf?1672660810=\u0026response-content-disposition=attachment%3B+filename%3DUltrasound_contrast_agent_hypersensitivi.pdf\u0026Expires=1732756866\u0026Signature=Fjn-EbW~GtLMnQzkqlBTlxSmR1rC7zOl3kLcvwfW4PotyqYemUNJXaNghccKk49hSdqrDDb~QolvDxstlem9OwYQLBwRs4i~q59v~uaD94E7uLH2c7yBMwC4lRcyq4tcQAAM9OR8JLgkVOULyEzxbWGoJVHVpHIYyymyKWWSbRDl5kQM-wOsSunjVbjE56GLBeQjIe0euZUmVZDXyrFQkip9FtFmYSEPDsgTEeNneeKkBXTy14aUzSE~H0SUR9MdSPZw8us5qY9fwFiZb-pPJwh6MqwTqR1Vlv0JAqNgmibxioPTjbyQ0FEpvgDE07T9tGdQpDWu7DuQXix1D2s8iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":15639,"name":"Ultrasound","url":"https://www.academia.edu/Documents/in/Ultrasound"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":349105,"name":"Polyethylene Glycol","url":"https://www.academia.edu/Documents/in/Polyethylene_Glycol"}],"urls":[{"id":27650580,"url":"http://academic.oup.com/ehjcimaging/article-pdf/22/9/959/39769494/jeab120.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969123"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969123/Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series"><img alt="Research paper thumbnail of Contrast echocardiography facilitates appropriate management of hospitalized patients with coronavirus disease 2019 (COVID-19) and suspected right ventricular masses: case series" class="work-thumbnail" src="https://attachments.academia-assets.com/89146553/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969123/Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series">Contrast echocardiography facilitates appropriate management of hospitalized patients with coronavirus disease 2019 (COVID-19) and suspected right ventricular masses: case series</a></div><div class="wp-workCard_item"><span>European Heart Journal: Case Reports</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with h...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with high incidence of venous thrombo-embolism. However, bleeding risk is also significant, causing difficulty in initiating and adjusting anticoagulation therapy in case of suspected thrombi. Cardiac masses can be challenging to be identified properly in the context of this disease. The use of bedside contrast echocardiography (CE) can be of a great value in this situation decreasing procedure-related risk and allowing proper diagnosis and management of a cardiac mass. Cases summary We present two cases who were admitted with severe COVID-19 infection. Both cases had additional risk factors for hypercoagulability. Un-enhanced echocardiography was performed and revealed right ventricular (RV) dysfunction with a suspected RV mass. The use of bedside CE could confirm a RV thrombus in the first case and exclude it in the second case. Hence, anticoagulation therapy could be adjusted accordingly in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a6e6b86ff73d12c1102fe98876e8fc2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146553,"asset_id":83969123,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146553/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969123"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969123"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969123; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969123]").text(description); $(".js-view-count[data-work-id=83969123]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969123; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969123']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969123, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a6e6b86ff73d12c1102fe98876e8fc2d" } } $('.js-work-strip[data-work-id=83969123]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969123,"title":"Contrast echocardiography facilitates appropriate management of hospitalized patients with coronavirus disease 2019 (COVID-19) and suspected right ventricular masses: case series","translated_title":"","metadata":{"abstract":"Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with high incidence of venous thrombo-embolism. However, bleeding risk is also significant, causing difficulty in initiating and adjusting anticoagulation therapy in case of suspected thrombi. Cardiac masses can be challenging to be identified properly in the context of this disease. The use of bedside contrast echocardiography (CE) can be of a great value in this situation decreasing procedure-related risk and allowing proper diagnosis and management of a cardiac mass. Cases summary We present two cases who were admitted with severe COVID-19 infection. Both cases had additional risk factors for hypercoagulability. Un-enhanced echocardiography was performed and revealed right ventricular (RV) dysfunction with a suspected RV mass. The use of bedside CE could confirm a RV thrombus in the first case and exclude it in the second case. Hence, anticoagulation therapy could be adjusted accordingly in...","publisher":"European heart journal. Case reports","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"European Heart Journal: Case Reports"},"translated_abstract":"Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with high incidence of venous thrombo-embolism. However, bleeding risk is also significant, causing difficulty in initiating and adjusting anticoagulation therapy in case of suspected thrombi. Cardiac masses can be challenging to be identified properly in the context of this disease. The use of bedside contrast echocardiography (CE) can be of a great value in this situation decreasing procedure-related risk and allowing proper diagnosis and management of a cardiac mass. Cases summary We present two cases who were admitted with severe COVID-19 infection. Both cases had additional risk factors for hypercoagulability. Un-enhanced echocardiography was performed and revealed right ventricular (RV) dysfunction with a suspected RV mass. The use of bedside CE could confirm a RV thrombus in the first case and exclude it in the second case. Hence, anticoagulation therapy could be adjusted accordingly in...","internal_url":"https://www.academia.edu/83969123/Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series","translated_internal_url":"","created_at":"2022-07-31T05:38:09.786-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146553,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146553/thumbnails/1.jpg","file_name":"ytaa575.pdf","download_url":"https://www.academia.edu/attachments/89146553/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Contrast_echocardiography_facilitates_ap.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146553/ytaa575-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DContrast_echocardiography_facilitates_ap.pdf\u0026Expires=1732756866\u0026Signature=S2JtpHUBR4Ekg0ciWijOCo992MhAThXdk0NN-YwiorihaCYorK~qEKmBF2ZMzwrrUf6gLYfcL0WbXI2TMCqcr26rV1quMmjGUwkjDsTT5N41KC10bOrGAkqxjE6X6yBY9UYUIwYlbfKkuugT8PQLJJ5V6M-WFbE3HqXicUytiADBsodCcElWzI~j5zdqwCvWhf3BlstKiB0gsZOjU3Pz~I-vHeK1PFROB-u0BBWHzK27ZrKgtUT8tY6-akl1xkmGAi4Y0~4nZbQwfarFTUoRxXWplgaDjaeawTCy1Dhiyc8vONN-UFCiYmJNOoOaJXySG0DtnlwJc7lckHnuEGV0ww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146553,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146553/thumbnails/1.jpg","file_name":"ytaa575.pdf","download_url":"https://www.academia.edu/attachments/89146553/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Contrast_echocardiography_facilitates_ap.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146553/ytaa575-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DContrast_echocardiography_facilitates_ap.pdf\u0026Expires=1732756866\u0026Signature=S2JtpHUBR4Ekg0ciWijOCo992MhAThXdk0NN-YwiorihaCYorK~qEKmBF2ZMzwrrUf6gLYfcL0WbXI2TMCqcr26rV1quMmjGUwkjDsTT5N41KC10bOrGAkqxjE6X6yBY9UYUIwYlbfKkuugT8PQLJJ5V6M-WFbE3HqXicUytiADBsodCcElWzI~j5zdqwCvWhf3BlstKiB0gsZOjU3Pz~I-vHeK1PFROB-u0BBWHzK27ZrKgtUT8tY6-akl1xkmGAi4Y0~4nZbQwfarFTUoRxXWplgaDjaeawTCy1Dhiyc8vONN-UFCiYmJNOoOaJXySG0DtnlwJc7lckHnuEGV0ww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969122/The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison"><img alt="Research paper thumbnail of The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison" class="work-thumbnail" src="https://attachments.academia-assets.com/89146520/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969122/The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison">The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison</a></div><div class="wp-workCard_item"><span>European Heart Journal - Cardiovascular Imaging</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of prospectively collected data of 276 patients (mean age 75 ± 15 years, 51% male) with normal transaortic flow [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and severe AS (aortic valve area &lt;1.0 cm2). The outcome measure was all-cause mortality. Of the 276 patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up of 3.2 ± 1.8 years (range 0–6.9 years), a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group vs. 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (P &lt; 0.001). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group vs. 61 (45.9%) in medically treated (P &lt; 0.001). In a propensity-matched multivariable Cox regression analysis adjusting fo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f565c7e95accb0f04f0c71c6919518d3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146520,"asset_id":83969122,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146520/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969122; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969122]").text(description); $(".js-view-count[data-work-id=83969122]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969122; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969122']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969122, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f565c7e95accb0f04f0c71c6919518d3" } } $('.js-work-strip[data-work-id=83969122]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969122,"title":"The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison","translated_title":"","metadata":{"abstract":"Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of prospectively collected data of 276 patients (mean age 75 ± 15 years, 51% male) with normal transaortic flow [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and severe AS (aortic valve area \u0026lt;1.0 cm2). The outcome measure was all-cause mortality. Of the 276 patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up of 3.2 ± 1.8 years (range 0–6.9 years), a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group vs. 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (P \u0026lt; 0.001). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group vs. 61 (45.9%) in medically treated (P \u0026lt; 0.001). In a propensity-matched multivariable Cox regression analysis adjusting fo...","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"European Heart Journal - Cardiovascular Imaging"},"translated_abstract":"Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of prospectively collected data of 276 patients (mean age 75 ± 15 years, 51% male) with normal transaortic flow [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and severe AS (aortic valve area \u0026lt;1.0 cm2). The outcome measure was all-cause mortality. Of the 276 patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up of 3.2 ± 1.8 years (range 0–6.9 years), a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group vs. 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (P \u0026lt; 0.001). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group vs. 61 (45.9%) in medically treated (P \u0026lt; 0.001). In a propensity-matched multivariable Cox regression analysis adjusting fo...","internal_url":"https://www.academia.edu/83969122/The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison","translated_internal_url":"","created_at":"2022-07-31T05:38:09.522-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146520,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146520/thumbnails/1.jpg","file_name":"jez191.pdf","download_url":"https://www.academia.edu/attachments/89146520/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_aortic_valve_replacement_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146520/jez191-libre.pdf?1659271510=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_aortic_valve_replacement_o.pdf\u0026Expires=1732756866\u0026Signature=Kuq-20q~1FTsjzBLCfIEyp0z4011wvkl768ZJFb0O40U63dPYmevmPc46f7R10bmrKPxTGI6hSj3uoEBLeOhkv0EkZ34rFRIGNeRsz3c78wDGLk8K9DsHYFQ0D4rN3veAPgRv4l1OMzLEDboV7jSKtGhbD7dHHVe8xeuz29EpfasgmQnIlK0C88oTOuLwEbMzpe2Nx6aBET4sYkXt3a1TAqHWs54ScsAP0zN-JyamPHQmYyV1CiSasPZyNrCzHEZhwxwyXA8C-~iBu3~W7BH9y5KJ3sp5IgxDVpNlMY8yhrvm8InTCa8lQGZrrruGtl-qUFB~XmDo3icy4aOJpIiwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146520,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146520/thumbnails/1.jpg","file_name":"jez191.pdf","download_url":"https://www.academia.edu/attachments/89146520/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_aortic_valve_replacement_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146520/jez191-libre.pdf?1659271510=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_aortic_valve_replacement_o.pdf\u0026Expires=1732756866\u0026Signature=Kuq-20q~1FTsjzBLCfIEyp0z4011wvkl768ZJFb0O40U63dPYmevmPc46f7R10bmrKPxTGI6hSj3uoEBLeOhkv0EkZ34rFRIGNeRsz3c78wDGLk8K9DsHYFQ0D4rN3veAPgRv4l1OMzLEDboV7jSKtGhbD7dHHVe8xeuz29EpfasgmQnIlK0C88oTOuLwEbMzpe2Nx6aBET4sYkXt3a1TAqHWs54ScsAP0zN-JyamPHQmYyV1CiSasPZyNrCzHEZhwxwyXA8C-~iBu3~W7BH9y5KJ3sp5IgxDVpNlMY8yhrvm8InTCa8lQGZrrruGtl-qUFB~XmDo3icy4aOJpIiwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"}],"urls":[{"id":22552362,"url":"http://academic.oup.com/ehjcimaging/advance-article-pdf/doi/10.1093/ehjci/jez191/28969595/jez191.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969121/First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial"><img alt="Research paper thumbnail of First experience with edoxaban and atrial fibrillation ablation – Insights from the ENGAGE AF-TIMI 48 trial" class="work-thumbnail" src="https://attachments.academia-assets.com/89146556/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969121/First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial">First experience with edoxaban and atrial fibrillation ablation – Insights from the ENGAGE AF-TIMI 48 trial</a></div><div class="wp-workCard_item"><span>International Journal of Cardiology</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0c985fdf42493b67fac34e5c97569b1c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146556,"asset_id":83969121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146556/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969121; 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Experience regarding the safety of edoxaban in this context is limited. In an exploratory analysis we therefore investigated the outcome of patients undergoing transcatheter AF ablation in the ENGAGE AF-TIMI 48 trial. Methods \u0026 results: During the trial, 193 transcatheter AF ablation procedures were performed in 169 patients. For the majority of ablations (n = 157, 81%), study drug was interrupted N 3 days (median time of interruption: 18 days, interquartile range 3-30 days); 86 ablations were performed with ≤10 days, and 36 ablations with ≤3 days study drug interruption. During the first 30 days after the ablation, one ischemic stroke was observed in the warfarin group and none in the higher-dose edoxaban regimen (HDER) or lower-dose edoxaban regimen (LDER) group. Three clinically relevant non-major (CRNM) bleeding events were observed in the warfarin group; one major bleed was seen in the HDER group; one minor bleed occurred in the LDER group. All bleeding events occurred among the patients with ≤10 days study drug interruption; in contrast, no ischemic events or deaths were observed in these patients. Conclusions: In this pilot evaluation of the ENGAGE AF-TIMI 48 trial, treatment with edoxaban was associated with a low risk of ischemic and bleeding events during the first 30 days post ablation.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"International Journal of Cardiology","grobid_abstract_attachment_id":89146556},"translated_abstract":null,"internal_url":"https://www.academia.edu/83969121/First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial","translated_internal_url":"","created_at":"2022-07-31T05:38:09.280-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146556,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146556/thumbnails/1.jpg","file_name":"j.ijcard.2017.05.09820220731-1-1os5lz6.pdf","download_url":"https://www.academia.edu/attachments/89146556/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_experience_with_edoxaban_and_atria.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146556/j.ijcard.2017.05.09820220731-1-1os5lz6-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DFirst_experience_with_edoxaban_and_atria.pdf\u0026Expires=1732756866\u0026Signature=QEnMQSasyvJlV8KbNPsUo7ltw3Lm1aWocktdJLm-gbGf7G5t5HR5ie-5voMBVlQ0K2PCET16JALorgolsxYno93-FTjazdZ9TzQ58iJKQOAh85YDVKffziVnFk3c8Hpc5l3qaMoXRGCwxHEjeWdhXykscCkq0myD4pD~o3mtgxHycLRKx0CHhBV21ecOFbYFfLt3zq6BxtRncefG5pc3LEKjI77BShnVL40LASTPryK7OID-RPseTBXJVqjT5ZKVNxotvYuIOUzycFCyFh3K-bSEqpeAWQqfoMxbvdr-EbAnkbGwiFdfJRuKR9VYDfEa4UkjHX4AM9eFuh45CNwN9g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146556,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146556/thumbnails/1.jpg","file_name":"j.ijcard.2017.05.09820220731-1-1os5lz6.pdf","download_url":"https://www.academia.edu/attachments/89146556/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_experience_with_edoxaban_and_atria.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146556/j.ijcard.2017.05.09820220731-1-1os5lz6-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DFirst_experience_with_edoxaban_and_atria.pdf\u0026Expires=1732756866\u0026Signature=QEnMQSasyvJlV8KbNPsUo7ltw3Lm1aWocktdJLm-gbGf7G5t5HR5ie-5voMBVlQ0K2PCET16JALorgolsxYno93-FTjazdZ9TzQ58iJKQOAh85YDVKffziVnFk3c8Hpc5l3qaMoXRGCwxHEjeWdhXykscCkq0myD4pD~o3mtgxHycLRKx0CHhBV21ecOFbYFfLt3zq6BxtRncefG5pc3LEKjI77BShnVL40LASTPryK7OID-RPseTBXJVqjT5ZKVNxotvYuIOUzycFCyFh3K-bSEqpeAWQqfoMxbvdr-EbAnkbGwiFdfJRuKR9VYDfEa4UkjHX4AM9eFuh45CNwN9g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":897823,"name":"Elsevier","url":"https://www.academia.edu/Documents/in/Elsevier"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":22552361,"url":"http://api.elsevier.com/content/article/PII:S0167527317320880?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969120"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969120/Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain"><img alt="Research paper thumbnail of Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain" class="work-thumbnail" src="https://attachments.academia-assets.com/89146555/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969120/Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain">Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain</a></div><div class="wp-workCard_item"><span>European heart journal cardiovascular Imaging</span><span>, Jan 23, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was -16.3 ± 7% in ES, lower compared with healthy controls (P &lt; 0.001) but similar to other PAH aetiologies (P = 0.6). Mean RV peak t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e674b054a47168e2486b8f9e6f3f2400" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146555,"asset_id":83969120,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146555/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969120"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969120"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969120; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969120]").text(description); $(".js-view-count[data-work-id=83969120]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969120; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969120']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969120, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e674b054a47168e2486b8f9e6f3f2400" } } $('.js-work-strip[data-work-id=83969120]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969120,"title":"Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain","translated_title":"","metadata":{"abstract":"Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was -16.3 ± 7% in ES, lower compared with healthy controls (P \u0026lt; 0.001) but similar to other PAH aetiologies (P = 0.6). Mean RV peak t...","publication_date":{"day":23,"month":1,"year":2016,"errors":{}},"publication_name":"European heart journal cardiovascular Imaging"},"translated_abstract":"Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was -16.3 ± 7% in ES, lower compared with healthy controls (P \u0026lt; 0.001) but similar to other PAH aetiologies (P = 0.6). Mean RV peak t...","internal_url":"https://www.academia.edu/83969120/Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain","translated_internal_url":"","created_at":"2022-07-31T05:38:09.090-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146555/thumbnails/1.jpg","file_name":"jew277.pdf","download_url":"https://www.academia.edu/attachments/89146555/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_remodelling_amongst_adults_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146555/jew277-libre.pdf?1659271509=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_remodelling_amongst_adults_with.pdf\u0026Expires=1732756866\u0026Signature=MUv5ihcTmGMnD-QqGEUn51ympcayYRMW26jVsiO8RZ2IyJ6Y1p0IklH5cf8MzS~Iwighb3HChGfdBaxTyepI1V0KP9mCPgcU5yZddXxFxBGCLM7zFaS8cyl3Nveut2jyj-Tpvm4J5FtBgDvUugZK1Xrpha4egXlTFUeJnr6l6JDGvUWaQzFM-5xCa~vmG9uA8MrYcHEnV3OUPjrg0Day184qn5Iu7iDm9ve0tZxEOeeeDwOdrr2zcZyyrlpiiywgjabSzaufSaMHY07wB2oGWqgvSqrNN2S0UC6cad0NDXnqeSDAdwAXI99bomqC-G-GWw8Eo0KvytVQoe4-a~b0xA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146555/thumbnails/1.jpg","file_name":"jew277.pdf","download_url":"https://www.academia.edu/attachments/89146555/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_remodelling_amongst_adults_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146555/jew277-libre.pdf?1659271509=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_remodelling_amongst_adults_with.pdf\u0026Expires=1732756866\u0026Signature=MUv5ihcTmGMnD-QqGEUn51ympcayYRMW26jVsiO8RZ2IyJ6Y1p0IklH5cf8MzS~Iwighb3HChGfdBaxTyepI1V0KP9mCPgcU5yZddXxFxBGCLM7zFaS8cyl3Nveut2jyj-Tpvm4J5FtBgDvUugZK1Xrpha4egXlTFUeJnr6l6JDGvUWaQzFM-5xCa~vmG9uA8MrYcHEnV3OUPjrg0Day184qn5Iu7iDm9ve0tZxEOeeeDwOdrr2zcZyyrlpiiywgjabSzaufSaMHY07wB2oGWqgvSqrNN2S0UC6cad0NDXnqeSDAdwAXI99bomqC-G-GWw8Eo0KvytVQoe4-a~b0xA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969119"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969119/Plaque_Neovascularization_Is_Increased_in_Human_Carotid_Atherosclerosis_Related_to_Prior_Neck_Radiotherapy_A_Contrast_Enhanced_Ultrasound_Study"><img alt="Research paper thumbnail of Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study" class="work-thumbnail" src="https://attachments.academia-assets.com/89146569/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969119/Plaque_Neovascularization_Is_Increased_in_Human_Carotid_Atherosclerosis_Related_to_Prior_Neck_Radiotherapy_A_Contrast_Enhanced_Ultrasound_Study">Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study</a></div><div class="wp-workCard_item"><span>JACC. Cardiovascular imaging</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascular...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries. Presence of IPN during contrast-enhanced ultrasound was judged semiquantitatively as grade 0 (absent), grade 1 (present but limited to plaque base), or grade 2 (extensive and noted within plaque body). Of 49 patients studied, 38 (78%) had plaques. The number of plaques was significantly greater in the RT than the non-RT arteries. Overall, 48 of 64 RT-side plaques (75%) had IPN comp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc7d4ac33e4297e25f2b9259d7005ad7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146569,"asset_id":83969119,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146569/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969119"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969119"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969119; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969119]").text(description); $(".js-view-count[data-work-id=83969119]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969119; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969119']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969119, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dc7d4ac33e4297e25f2b9259d7005ad7" } } $('.js-work-strip[data-work-id=83969119]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969119,"title":"Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study","translated_title":"","metadata":{"abstract":"The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries. Presence of IPN during contrast-enhanced ultrasound was judged semiquantitatively as grade 0 (absent), grade 1 (present but limited to plaque base), or grade 2 (extensive and noted within plaque body). Of 49 patients studied, 38 (78%) had plaques. The number of plaques was significantly greater in the RT than the non-RT arteries. Overall, 48 of 64 RT-side plaques (75%) had IPN comp...","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"JACC. Cardiovascular imaging"},"translated_abstract":"The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries. Presence of IPN during contrast-enhanced ultrasound was judged semiquantitatively as grade 0 (absent), grade 1 (present but limited to plaque base), or grade 2 (extensive and noted within plaque body). Of 49 patients studied, 38 (78%) had plaques. The number of plaques was significantly greater in the RT than the non-RT arteries. Overall, 48 of 64 RT-side plaques (75%) had IPN comp...","internal_url":"https://www.academia.edu/83969119/Plaque_Neovascularization_Is_Increased_in_Human_Carotid_Atherosclerosis_Related_to_Prior_Neck_Radiotherapy_A_Contrast_Enhanced_Ultrasound_Study","translated_internal_url":"","created_at":"2022-07-31T05:38:08.927-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146569,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146569/thumbnails/1.jpg","file_name":"668.full.pdf","download_url":"https://www.academia.edu/attachments/89146569/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Plaque_Neovascularization_Is_Increased_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146569/668.full-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DPlaque_Neovascularization_Is_Increased_i.pdf\u0026Expires=1732756866\u0026Signature=YmMoRKAjcRSkIad4trOzCTDzOrMxUKSppGe9HzkCX35nNFhkqB8PKpSDGZDHpk0CUtwDOrQT3NzShqJ-YnSgZ6Bx-E9Vxo6STO73Ib2cY3OsLSKfx~ZgYmSsNAcYzkiziXdzk9LgukVWe~7~vBMJnhlcMk3ZwCvGKlx3UY4xBKO8o2tM3vBrgQkn4Jl477N1mmVW1RDWxm-cSOWgXtamHSsTW9xbNC-zDTYO0cbwll5oWeBMV8jf67bv4Z~X2wMZqmqHUt7U-eENgFJwzk0binES2As80bER9sINHLSW7S1tmp5~7-f-IMIyqoPX0olpmuxJg95dtxYpsbVOO7-7Mg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Plaque_Neovascularization_Is_Increased_in_Human_Carotid_Atherosclerosis_Related_to_Prior_Neck_Radiotherapy_A_Contrast_Enhanced_Ultrasound_Study","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146569,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146569/thumbnails/1.jpg","file_name":"668.full.pdf","download_url":"https://www.academia.edu/attachments/89146569/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Plaque_Neovascularization_Is_Increased_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146569/668.full-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DPlaque_Neovascularization_Is_Increased_i.pdf\u0026Expires=1732756866\u0026Signature=YmMoRKAjcRSkIad4trOzCTDzOrMxUKSppGe9HzkCX35nNFhkqB8PKpSDGZDHpk0CUtwDOrQT3NzShqJ-YnSgZ6Bx-E9Vxo6STO73Ib2cY3OsLSKfx~ZgYmSsNAcYzkiziXdzk9LgukVWe~7~vBMJnhlcMk3ZwCvGKlx3UY4xBKO8o2tM3vBrgQkn4Jl477N1mmVW1RDWxm-cSOWgXtamHSsTW9xbNC-zDTYO0cbwll5oWeBMV8jf67bv4Z~X2wMZqmqHUt7U-eENgFJwzk0binES2As80bER9sINHLSW7S1tmp5~7-f-IMIyqoPX0olpmuxJg95dtxYpsbVOO7-7Mg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":8501,"name":"Phospholipids","url":"https://www.academia.edu/Documents/in/Phospholipids"},{"id":19354,"name":"Radiotherapy","url":"https://www.academia.edu/Documents/in/Radiotherapy"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":375296,"name":"Observer Variation","url":"https://www.academia.edu/Documents/in/Observer_Variation"},{"id":469033,"name":"Radiation Injuries","url":"https://www.academia.edu/Documents/in/Radiation_Injuries"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests"},{"id":1407305,"name":"Contrast Media","url":"https://www.academia.edu/Documents/in/Contrast_Media"},{"id":2579149,"name":"Carotid Arteries","url":"https://www.academia.edu/Documents/in/Carotid_Arteries"},{"id":3616628,"name":"Head and neck neoplasms","url":"https://www.academia.edu/Documents/in/Head_and_neck_neoplasms"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969118"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969118/Insulin_induced_hypoglycaemia_and_the_detection_of_myocardial_injury_using_an_ultrasensitive_troponin_assay"><img alt="Research paper thumbnail of Insulin-induced hypoglycaemia and the detection of myocardial injury using an ultrasensitive troponin assay" class="work-thumbnail" src="https://attachments.academia-assets.com/89146554/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969118/Insulin_induced_hypoglycaemia_and_the_detection_of_myocardial_injury_using_an_ultrasensitive_troponin_assay">Insulin-induced hypoglycaemia and the detection of myocardial injury using an ultrasensitive troponin assay</a></div><div class="wp-workCard_item"><span>International Journal of Cardiology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9cc7d969c5322db6436c981a4fe4003" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146554,"asset_id":83969118,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146554/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969118"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969118"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969118; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969115"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969115/Resting_Aortic_Valve_Area_at_Normal_Transaortic_Flow_Rate_Reflects_True_Valve_Area_in_Suspected_Low_Gradient_Severe_Aortic_Stenosis"><img alt="Research paper thumbnail of Resting Aortic Valve Area at Normal Transaortic Flow Rate Reflects True Valve Area in Suspected Low-Gradient Severe Aortic Stenosis" class="work-thumbnail" src="https://attachments.academia-assets.com/89146570/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969115/Resting_Aortic_Valve_Area_at_Normal_Transaortic_Flow_Rate_Reflects_True_Valve_Area_in_Suspected_Low_Gradient_Severe_Aortic_Stenosis">Resting Aortic Valve Area at Normal Transaortic Flow Rate Reflects True Valve Area in Suspected Low-Gradient Severe Aortic Stenosis</a></div><div class="wp-workCard_item"><span>JACC: Cardiovascular Imaging</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b78bf0f9f3d78461a581db22c3524f03" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146570,"asset_id":83969115,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146570/download_file?st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969115"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969115; 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BACKGROUND SE may help to distinguish between true severe aortic stenosis and pseudosevere aortic stenosis in patients with low aortic valve area (AVA) and mean gradient. However, if rest flow rate is normal, then SE may not confer any additional diagnostic value, irrespective of resting left ventricular ejection fraction (LVEF) and indexed stroke volume (SVi). METHODS Sixty-seven patients with suspected low-flow, low-gradient aortic stenosis who underwent SE were retrospectively studied. Following stratification by rest LVEF, SVi, and flow rate-using cutoffs of 50%, 35 ml/m 2 , and 200 ml/s, respectively-we tested for significant changes in AVA during SE. RESULTS Mean age was 77 AE 9 years and 60% of patients were male. 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969114/Left_atrial_enlargement_causing_dysphagia_and_weight_loss_a_rare_contraindication_for_catheter_ablation_therapy_in_a_patient_with_complex_atrial_arrhythmia"><img alt="Research paper thumbnail of Left atrial enlargement causing dysphagia and weight loss: a rare contraindication for catheter ablation therapy in a patient with complex atrial arrhythmia" class="work-thumbnail" src="https://attachments.academia-assets.com/89146549/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969114/Left_atrial_enlargement_causing_dysphagia_and_weight_loss_a_rare_contraindication_for_catheter_ablation_therapy_in_a_patient_with_complex_atrial_arrhythmia">Left atrial enlargement causing dysphagia and weight loss: a rare contraindication for catheter ablation therapy in a patient with complex atrial arrhythmia</a></div><div class="wp-workCard_item"><span>International journal of cardiology</span><span>, Jan 20, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="20ec84c4f9137016cd57cbcb95e834b5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146549,"asset_id":83969114,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146549/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969114"><a 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969113/Myocardial_Viability_Comparison_with_Other_Imaging_Techniques"><img alt="Research paper thumbnail of Myocardial Viability: Comparison with Other Imaging Techniques" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969113/Myocardial_Viability_Comparison_with_Other_Imaging_Techniques">Myocardial Viability: Comparison with Other Imaging Techniques</a></div><div class="wp-workCard_item"><span>Contrast Echocardiography in Clinical Practice</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Myocardial viability may be defined as myocardium with preserved metabolic, cel lular and membran...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Myocardial viability may be defined as myocardium with preserved metabolic, cel lular and membrane function which allows the myocardium to maintain its contractile function. Thus, the mere presence of contractile function suggests that the myocardium is viable. However, the clinical scenario where assessment of myocardial viability is an issue is when there is regional or global left ventricular dysfunction in the context of coronary artery disease. There are two broad scenarios of coronary artery disease where this can occur. The first scenario is when the reduction of contractile function with preserved metabolic, cellular and membrane function may occur when myocardial blood flow is chronically reduced (‘hibernating myocardium’) or when the myocardial blood flow is normal at rest but there is repetitive demand-induced ischaemia in presence of non-flow-limiting coronary artery stenosis at rest (‘stunned, myocardium’) [2].</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969113"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969113"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969113; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969113]").text(description); $(".js-view-count[data-work-id=83969113]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969113; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969113']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969113, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=83969113]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969113,"title":"Myocardial Viability: Comparison with Other Imaging Techniques","translated_title":"","metadata":{"abstract":"Myocardial viability may be defined as myocardium with preserved metabolic, cel lular and membrane function which allows the myocardium to maintain its contractile function. 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The first scenario is when the reduction of contractile function with preserved metabolic, cellular and membrane function may occur when myocardial blood flow is chronically reduced (‘hibernating myocardium’) or when the myocardial blood flow is normal at rest but there is repetitive demand-induced ischaemia in presence of non-flow-limiting coronary artery stenosis at rest (‘stunned, myocardium’) [2].","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Contrast Echocardiography in Clinical Practice"},"translated_abstract":"Myocardial viability may be defined as myocardium with preserved metabolic, cel lular and membrane function which allows the myocardium to maintain its contractile function. Thus, the mere presence of contractile function suggests that the myocardium is viable. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969112"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969112/Diagnosis_of_coronary_artery_disease_in_heart_failure_Role_of_myocardial_contrast_echocardiography_in_patients_with_first_presentation_of_heart_failure_not_due_to_acute_myocardial_infarction"><img alt="Research paper thumbnail of Diagnosis of coronary artery disease in heart failure: Role of myocardial contrast echocardiography in patients with first presentation of heart failure not due to acute myocardial infarction" class="work-thumbnail" src="https://attachments.academia-assets.com/89146552/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969112/Diagnosis_of_coronary_artery_disease_in_heart_failure_Role_of_myocardial_contrast_echocardiography_in_patients_with_first_presentation_of_heart_failure_not_due_to_acute_myocardial_infarction">Diagnosis of coronary artery disease in heart failure: Role of myocardial contrast echocardiography in patients with first presentation of heart failure not due to acute myocardial infarction</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="53be6559804ff3c2cfd537832a359cad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146552,"asset_id":83969112,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146552/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969112"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969112"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969112; 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METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasivestrategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, −1.8 percentage points; 95% CI, −4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. 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src="https://attachments.academia-assets.com/112328589/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116106479/Baseline_Characteristics_and_Risk_Profiles_of_Participants_in_the_ISCHEMIA_Randomized_Clinical_Trial">Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial</a></div><div class="wp-workCard_item"><span>JAMA Cardiology</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="68f036ab1971c940df1fd854609b58d9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112328589,"asset_id":116106479,"asset_type":"Work","button_location":"profile"}" 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "68f036ab1971c940df1fd854609b58d9" } } $('.js-work-strip[data-work-id=116106479]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116106479,"title":"Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial","translated_title":"","metadata":{"publisher":"American Medical Association (AMA)","grobid_abstract":"It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. OBJECTIVE To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. DESIGN, SETTING, AND PARTICIPANTS The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (\u003c50% for imaging stress test and \u003c70% for ETT). The study included 341 enrolling sites (320 randomizing) in 38 countries and patients with SIHD and moderate or severe ischemia on stress testing. Data presented were extracted on December 17, 2018. MAIN OUTCOMES AND MEASURES Enrolled, excluded, and randomized participants' baseline characteristics. No clinical outcomes are reported. RESULTS A total of 8518 patients were enrolled, and 5179 were randomized. Common reasons for exclusion were core laboratory determination of insufficient ischemia, unprotected left main stenosis of at least 50%, or no stenosis that met study obstructive CAD criteria on study coronary computed tomography angiography. Randomized participants had a median age of 64 years, with 1168 women (22.6%), 1726 nonwhite participants (33.7%), 748 Hispanic participants (15.5%), 2122 with diabetes (41.0%), and 4643 with a history of angina (89.7%). Among the 3909 participants randomized after stress imaging, core laboratory assessment of ischemia severity (in 3901 participants) was severe in 1748 (44.8%), moderate in 1600 (41.0%), mild in 317 (8.1%) and none or uninterpretable in 236 (6.0%), Among the 1270 participants who were randomized after nonimaging ETT, core laboratory determination of ischemia severity (in 1266 participants) was severe (an eligibility criterion) in 1051 (83.0%), moderate in 101 (8.0%), mild in 34 (2.7%) and none or uninterpretable in 80 (6.3%). Among the 3912 of 5179 randomized participants who underwent coronary computed tomography angiography, 79.0% had multivessel CAD (n = 2679 of 3390) and 86.8% had left anterior descending (LAD) stenosis (n = 3190 of 3677) (proximal in 46.8% [n = 1749 of 3739]). Participants undergoing ETT had greater frequency of 3-vessel CAD, LAD, and proximal LAD stenosis than participants undergoing stress imaging. CONCLUSIONS AND RELEVANCE The ISCHEMIA trial randomized an SIHD population with moderate or severe ischemia on stress testing, of whom most had multivessel CAD.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"JAMA 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113292495/Association_of_Sex_With_Severity_of_Coronary_Artery_Disease_Ischemia_and_Symptom_Burden_in_Patients_With_Moderate_or_Severe_Ischemia"><img alt="Research paper thumbnail of Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia" class="work-thumbnail" src="https://attachments.academia-assets.com/110289537/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113292495/Association_of_Sex_With_Severity_of_Coronary_Artery_Disease_Ischemia_and_Symptom_Burden_in_Patients_With_Moderate_or_Severe_Ischemia">Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia</a></div><div class="wp-workCard_item"><span>JAMA Cardiology</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d40bdd88cccc5d3d53ece52e69ec722" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110289537,"asset_id":113292495,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110289537/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113292495"><a class="js-profile-work-strip-edit-button" 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$('.js-work-strip[data-work-id=113292495]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113292495,"title":"Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia","translated_title":"","metadata":{"publisher":"American Medical Association (AMA)","grobid_abstract":"; for the ISCHEMIA Research Group IMPORTANCE While many features of stable ischemic heart disease vary by sex, differences in ischemia, coronary anatomy, and symptoms by sex have not been investigated among patients with moderate or severe ischemia. The enrolled ISCHEMIA trial cohort that underwent coronary computed tomographic angiography (CCTA) was required to have obstructive coronary artery disease (CAD) for randomization. OBJECTIVE To describe sex differences in stress testing, CCTA findings, and symptoms in ISCHEMIA trial participants. DESIGN, SETTING, AND PARTICIPANTS This secondary analysis of the multicenter ISCHEMIA randomized clinical trial analyzed baseline characteristics of patients with stable ischemic heart disease. Individuals were enrolled from July 2012 to January 2018 based on local reading of moderate or severe ischemia on a stress test, after which blinded CCTA was performed in most. Core laboratories reviewed stress tests and CCTAs. Participants with no obstructive CAD or with left main CAD of 50% or greater were excluded. Those who met eligibility criteria including CCTA (if performed) were randomized to a routine invasive or a conservative management strategy (N = 5179). Angina was assessed using the Seattle Angina Questionnaire. Analysis began October 1, 2018. INTERVENTIONS CCTA and angina assessment. MAIN OUTCOMES AND MEASURES Sex differences in stress test, CCTA findings, and symptom severity. RESULTS Of 8518 patients enrolled, 6256 (77%) were men. Women were more likely to have no obstructive CAD (\u003c50% stenosis in all vessels on CCTA) (352 of 1022 [34.4%] vs 378 of 3353 [11.3%]). Of individuals who were randomized, women had more angina at baseline than men (median [interquartile range] Seattle Angina Questionnaire Angina Frequency score: 80 [70-100] vs 90 [70-100]). Women had less severe ischemia on stress imaging (383 of 919 [41.7%] vs 1363 of 2972 [45.9%] with severe ischemia; 386 of 919 [42.0%] vs 1215 of 2972 [40.9%] with moderate ischemia; and 150 of 919 [16.3%] vs 394 of 2972 [13.3%] with mild or no ischemia). Ischemia was similar by sex on exercise tolerance testing. Women had less extensive CAD on CCTA (205 of 568 women [36%] vs 1142 of 2418 men [47%] with 3-vessel disease; 184 of 568 women [32%] vs 754 of 2418 men [31%] with 2-vessel disease; and 178 of 568 women [31%] vs 519 of 2418 men [22%] with 1-vessel disease). Female sex was independently associated with greater angina frequency (odds ratio, 1.41; 95% CI, 1.13-1.76). CONCLUSIONS AND RELEVANCE Women in the ISCHEMIA trial had more frequent angina, independent of less extensive CAD, and less severe ischemia than men. 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Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":789977,"name":"Coronary Artery Disease","url":"https://www.academia.edu/Documents/in/Coronary_Artery_Disease"},{"id":882996,"name":"Medicine and Health Sciences","url":"https://www.academia.edu/Documents/in/Medicine_and_Health_Sciences"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":31958764,"url":"http://academic.oup.com/eurheartj/article-pdf/35/33/2260/6730889/ehu038.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102764754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102764754/Comparative_Effectiveness_of_Exercise_Electrocardiography_versus_Exercise_Echocardiography_in_Women_Presenting_with_Suspected_Coronary_Artery_Disease_A_Randomised_Study"><img alt="Research paper thumbnail of Comparative Effectiveness of Exercise Electrocardiography versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study" class="work-thumbnail" src="https://attachments.academia-assets.com/102947504/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102764754/Comparative_Effectiveness_of_Exercise_Electrocardiography_versus_Exercise_Echocardiography_in_Women_Presenting_with_Suspected_Coronary_Artery_Disease_A_Randomised_Study">Comparative Effectiveness of Exercise Electrocardiography versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study</a></div><div class="wp-workCard_item"><span>European Heart Journal Open</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective There is a paucity of randomised diagnostic studies in women with suspected coronary ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective There is a paucity of randomised diagnostic studies in women with suspected coronary artery disease(CAD). This study sought to assess the relative value of exercise stress echocardiography (ESE) compared with exercise ECG (Ex-ECG) in women with CAD. Methods Accordingly, 416 women with no prior CAD and intermediate probability of CAD (mean pre-test probability 41%), were randomized to undergo either Ex-ECG or ESE. The primary endpoints were the positive predictive value (PPV) for the detection of significant CAD and downstream resource utilisation. Results The PPV of ESE and Ex-ECG were 33% and 30% (p = 0.87) respectively for the detection of CAD. There were similar clinic visits (36 vs 29, p = 0.44) and emergency visits with chest pain (28 vs 25, p = 0.55) in the Ex-ECG and ESE arms respectively. At 2.9 years,cardiac events were 6 Ex-ECG vs 3 ESE, p = 0.31. Although initial diagnosis costs were higher for ESE, more women underwent further CAD testing in the Ex-ECG arm comp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b81d60d8cabd643c788e8da0124904b0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102947504,"asset_id":102764754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102947504/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102764754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102764754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102764754; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102764754]").text(description); $(".js-view-count[data-work-id=102764754]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102764754; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102764754']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102764754, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b81d60d8cabd643c788e8da0124904b0" } } $('.js-work-strip[data-work-id=102764754]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102764754,"title":"Comparative Effectiveness of Exercise Electrocardiography versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study","translated_title":"","metadata":{"abstract":"Objective There is a paucity of randomised diagnostic studies in women with suspected coronary artery disease(CAD). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94140671"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94140671/Ultrasound_contrast_agent_hypersensitivity_in_patients_allergic_to_polyethylene_glycol_position_statement_by_the_European_Association_of_Cardiovascular_Imaging"><img alt="Research paper thumbnail of Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging" class="work-thumbnail" src="https://attachments.academia-assets.com/96681446/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94140671/Ultrasound_contrast_agent_hypersensitivity_in_patients_allergic_to_polyethylene_glycol_position_statement_by_the_European_Association_of_Cardiovascular_Imaging">Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging</a></div><div class="wp-workCard_item"><span>European Heart Journal - Cardiovascular Imaging</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Food and Drug Administration alert enhances our understanding of the mechanism of severe reac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Food and Drug Administration alert enhances our understanding of the mechanism of severe reactions to ultrasound-enhancing agents (UEAs). The known incidence of these reactions remains low and unchanged (1 in 10 000 administrations). Because the risk-to-benefit ratio for ultrasound contrast agents (UCAs) remains extremely low, we do not advise any changes to laboratory policy regarding indications for their use. The use of these agents should continue in situations where they have been shown to be impactful. Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, to polyethylene glycol (PEG) (macrogol), or to PEG-containing products, such as certain bowel preps for colonoscopy or laxatives.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f03c7c666e1f5bfb44ffb62c18d55df3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":96681446,"asset_id":94140671,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/96681446/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94140671"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94140671"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94140671; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94140671]").text(description); $(".js-view-count[data-work-id=94140671]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94140671; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94140671']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94140671, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f03c7c666e1f5bfb44ffb62c18d55df3" } } $('.js-work-strip[data-work-id=94140671]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94140671,"title":"Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging","translated_title":"","metadata":{"abstract":"The Food and Drug Administration alert enhances our understanding of the mechanism of severe reactions to ultrasound-enhancing agents (UEAs). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969123"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969123/Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series"><img alt="Research paper thumbnail of Contrast echocardiography facilitates appropriate management of hospitalized patients with coronavirus disease 2019 (COVID-19) and suspected right ventricular masses: case series" class="work-thumbnail" src="https://attachments.academia-assets.com/89146553/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969123/Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series">Contrast echocardiography facilitates appropriate management of hospitalized patients with coronavirus disease 2019 (COVID-19) and suspected right ventricular masses: case series</a></div><div class="wp-workCard_item"><span>European Heart Journal: Case Reports</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with h...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with high incidence of venous thrombo-embolism. However, bleeding risk is also significant, causing difficulty in initiating and adjusting anticoagulation therapy in case of suspected thrombi. Cardiac masses can be challenging to be identified properly in the context of this disease. The use of bedside contrast echocardiography (CE) can be of a great value in this situation decreasing procedure-related risk and allowing proper diagnosis and management of a cardiac mass. Cases summary We present two cases who were admitted with severe COVID-19 infection. Both cases had additional risk factors for hypercoagulability. Un-enhanced echocardiography was performed and revealed right ventricular (RV) dysfunction with a suspected RV mass. The use of bedside CE could confirm a RV thrombus in the first case and exclude it in the second case. Hence, anticoagulation therapy could be adjusted accordingly in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a6e6b86ff73d12c1102fe98876e8fc2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146553,"asset_id":83969123,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146553/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969123"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969123"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969123; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969123]").text(description); $(".js-view-count[data-work-id=83969123]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969123; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969123']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969123, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a6e6b86ff73d12c1102fe98876e8fc2d" } } $('.js-work-strip[data-work-id=83969123]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969123,"title":"Contrast echocardiography facilitates appropriate management of hospitalized patients with coronavirus disease 2019 (COVID-19) and suspected right ventricular masses: case series","translated_title":"","metadata":{"abstract":"Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with high incidence of venous thrombo-embolism. However, bleeding risk is also significant, causing difficulty in initiating and adjusting anticoagulation therapy in case of suspected thrombi. Cardiac masses can be challenging to be identified properly in the context of this disease. The use of bedside contrast echocardiography (CE) can be of a great value in this situation decreasing procedure-related risk and allowing proper diagnosis and management of a cardiac mass. Cases summary We present two cases who were admitted with severe COVID-19 infection. Both cases had additional risk factors for hypercoagulability. Un-enhanced echocardiography was performed and revealed right ventricular (RV) dysfunction with a suspected RV mass. The use of bedside CE could confirm a RV thrombus in the first case and exclude it in the second case. Hence, anticoagulation therapy could be adjusted accordingly in...","publisher":"European heart journal. Case reports","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"European Heart Journal: Case Reports"},"translated_abstract":"Background Coronavirus disease 2019 (COVID-19) infection is associated with a coagulopathy with high incidence of venous thrombo-embolism. However, bleeding risk is also significant, causing difficulty in initiating and adjusting anticoagulation therapy in case of suspected thrombi. Cardiac masses can be challenging to be identified properly in the context of this disease. The use of bedside contrast echocardiography (CE) can be of a great value in this situation decreasing procedure-related risk and allowing proper diagnosis and management of a cardiac mass. Cases summary We present two cases who were admitted with severe COVID-19 infection. Both cases had additional risk factors for hypercoagulability. Un-enhanced echocardiography was performed and revealed right ventricular (RV) dysfunction with a suspected RV mass. The use of bedside CE could confirm a RV thrombus in the first case and exclude it in the second case. Hence, anticoagulation therapy could be adjusted accordingly in...","internal_url":"https://www.academia.edu/83969123/Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series","translated_internal_url":"","created_at":"2022-07-31T05:38:09.786-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146553,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146553/thumbnails/1.jpg","file_name":"ytaa575.pdf","download_url":"https://www.academia.edu/attachments/89146553/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Contrast_echocardiography_facilitates_ap.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146553/ytaa575-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DContrast_echocardiography_facilitates_ap.pdf\u0026Expires=1732756866\u0026Signature=S2JtpHUBR4Ekg0ciWijOCo992MhAThXdk0NN-YwiorihaCYorK~qEKmBF2ZMzwrrUf6gLYfcL0WbXI2TMCqcr26rV1quMmjGUwkjDsTT5N41KC10bOrGAkqxjE6X6yBY9UYUIwYlbfKkuugT8PQLJJ5V6M-WFbE3HqXicUytiADBsodCcElWzI~j5zdqwCvWhf3BlstKiB0gsZOjU3Pz~I-vHeK1PFROB-u0BBWHzK27ZrKgtUT8tY6-akl1xkmGAi4Y0~4nZbQwfarFTUoRxXWplgaDjaeawTCy1Dhiyc8vONN-UFCiYmJNOoOaJXySG0DtnlwJc7lckHnuEGV0ww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Contrast_echocardiography_facilitates_appropriate_management_of_hospitalized_patients_with_coronavirus_disease_2019_COVID_19_and_suspected_right_ventricular_masses_case_series","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146553,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146553/thumbnails/1.jpg","file_name":"ytaa575.pdf","download_url":"https://www.academia.edu/attachments/89146553/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Contrast_echocardiography_facilitates_ap.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146553/ytaa575-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DContrast_echocardiography_facilitates_ap.pdf\u0026Expires=1732756866\u0026Signature=S2JtpHUBR4Ekg0ciWijOCo992MhAThXdk0NN-YwiorihaCYorK~qEKmBF2ZMzwrrUf6gLYfcL0WbXI2TMCqcr26rV1quMmjGUwkjDsTT5N41KC10bOrGAkqxjE6X6yBY9UYUIwYlbfKkuugT8PQLJJ5V6M-WFbE3HqXicUytiADBsodCcElWzI~j5zdqwCvWhf3BlstKiB0gsZOjU3Pz~I-vHeK1PFROB-u0BBWHzK27ZrKgtUT8tY6-akl1xkmGAi4Y0~4nZbQwfarFTUoRxXWplgaDjaeawTCy1Dhiyc8vONN-UFCiYmJNOoOaJXySG0DtnlwJc7lckHnuEGV0ww__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969122/The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison"><img alt="Research paper thumbnail of The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison" class="work-thumbnail" src="https://attachments.academia-assets.com/89146520/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969122/The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison">The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison</a></div><div class="wp-workCard_item"><span>European Heart Journal - Cardiovascular Imaging</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of prospectively collected data of 276 patients (mean age 75 ± 15 years, 51% male) with normal transaortic flow [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and severe AS (aortic valve area &lt;1.0 cm2). The outcome measure was all-cause mortality. Of the 276 patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up of 3.2 ± 1.8 years (range 0–6.9 years), a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group vs. 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (P &lt; 0.001). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group vs. 61 (45.9%) in medically treated (P &lt; 0.001). In a propensity-matched multivariable Cox regression analysis adjusting fo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f565c7e95accb0f04f0c71c6919518d3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146520,"asset_id":83969122,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146520/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969122; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969122]").text(description); $(".js-view-count[data-work-id=83969122]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969122; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969122']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969122, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f565c7e95accb0f04f0c71c6919518d3" } } $('.js-work-strip[data-work-id=83969122]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969122,"title":"The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison","translated_title":"","metadata":{"abstract":"Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of prospectively collected data of 276 patients (mean age 75 ± 15 years, 51% male) with normal transaortic flow [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and severe AS (aortic valve area \u0026lt;1.0 cm2). The outcome measure was all-cause mortality. Of the 276 patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up of 3.2 ± 1.8 years (range 0–6.9 years), a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group vs. 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (P \u0026lt; 0.001). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group vs. 61 (45.9%) in medically treated (P \u0026lt; 0.001). In a propensity-matched multivariable Cox regression analysis adjusting fo...","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"European Heart Journal - Cardiovascular Imaging"},"translated_abstract":"Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of prospectively collected data of 276 patients (mean age 75 ± 15 years, 51% male) with normal transaortic flow [flow rate (FR) ≥200 mL/s or stroke volume index (SVi) ≥35 mL/m2] and severe AS (aortic valve area \u0026lt;1.0 cm2). The outcome measure was all-cause mortality. Of the 276 patients, 151 (55%) were medically treated, while 125 (45%) underwent an AVR. Over a mean follow-up of 3.2 ± 1.8 years (range 0–6.9 years), a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group vs. 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (P \u0026lt; 0.001). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group vs. 61 (45.9%) in medically treated (P \u0026lt; 0.001). In a propensity-matched multivariable Cox regression analysis adjusting fo...","internal_url":"https://www.academia.edu/83969122/The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison","translated_internal_url":"","created_at":"2022-07-31T05:38:09.522-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146520,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146520/thumbnails/1.jpg","file_name":"jez191.pdf","download_url":"https://www.academia.edu/attachments/89146520/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_aortic_valve_replacement_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146520/jez191-libre.pdf?1659271510=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_aortic_valve_replacement_o.pdf\u0026Expires=1732756866\u0026Signature=Kuq-20q~1FTsjzBLCfIEyp0z4011wvkl768ZJFb0O40U63dPYmevmPc46f7R10bmrKPxTGI6hSj3uoEBLeOhkv0EkZ34rFRIGNeRsz3c78wDGLk8K9DsHYFQ0D4rN3veAPgRv4l1OMzLEDboV7jSKtGhbD7dHHVe8xeuz29EpfasgmQnIlK0C88oTOuLwEbMzpe2Nx6aBET4sYkXt3a1TAqHWs54ScsAP0zN-JyamPHQmYyV1CiSasPZyNrCzHEZhwxwyXA8C-~iBu3~W7BH9y5KJ3sp5IgxDVpNlMY8yhrvm8InTCa8lQGZrrruGtl-qUFB~XmDo3icy4aOJpIiwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_impact_of_aortic_valve_replacement_on_survival_in_patients_with_normal_flow_low_gradient_severe_aortic_stenosis_a_propensity_matched_comparison","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146520,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146520/thumbnails/1.jpg","file_name":"jez191.pdf","download_url":"https://www.academia.edu/attachments/89146520/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_aortic_valve_replacement_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146520/jez191-libre.pdf?1659271510=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_aortic_valve_replacement_o.pdf\u0026Expires=1732756866\u0026Signature=Kuq-20q~1FTsjzBLCfIEyp0z4011wvkl768ZJFb0O40U63dPYmevmPc46f7R10bmrKPxTGI6hSj3uoEBLeOhkv0EkZ34rFRIGNeRsz3c78wDGLk8K9DsHYFQ0D4rN3veAPgRv4l1OMzLEDboV7jSKtGhbD7dHHVe8xeuz29EpfasgmQnIlK0C88oTOuLwEbMzpe2Nx6aBET4sYkXt3a1TAqHWs54ScsAP0zN-JyamPHQmYyV1CiSasPZyNrCzHEZhwxwyXA8C-~iBu3~W7BH9y5KJ3sp5IgxDVpNlMY8yhrvm8InTCa8lQGZrrruGtl-qUFB~XmDo3icy4aOJpIiwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"}],"urls":[{"id":22552362,"url":"http://academic.oup.com/ehjcimaging/advance-article-pdf/doi/10.1093/ehjci/jez191/28969595/jez191.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969121/First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial"><img alt="Research paper thumbnail of First experience with edoxaban and atrial fibrillation ablation – Insights from the ENGAGE AF-TIMI 48 trial" class="work-thumbnail" src="https://attachments.academia-assets.com/89146556/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969121/First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial">First experience with edoxaban and atrial fibrillation ablation – Insights from the ENGAGE AF-TIMI 48 trial</a></div><div class="wp-workCard_item"><span>International Journal of Cardiology</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0c985fdf42493b67fac34e5c97569b1c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146556,"asset_id":83969121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146556/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969121; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969121]").text(description); $(".js-view-count[data-work-id=83969121]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969121; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969121']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969121, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0c985fdf42493b67fac34e5c97569b1c" } } $('.js-work-strip[data-work-id=83969121]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969121,"title":"First experience with edoxaban and atrial fibrillation ablation – Insights from the ENGAGE AF-TIMI 48 trial","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Background: Atrial fibrillation (AF) ablation procedures are increasingly being performed in patients receiving direct oral anticoagulants (DOACs). Experience regarding the safety of edoxaban in this context is limited. In an exploratory analysis we therefore investigated the outcome of patients undergoing transcatheter AF ablation in the ENGAGE AF-TIMI 48 trial. Methods \u0026 results: During the trial, 193 transcatheter AF ablation procedures were performed in 169 patients. For the majority of ablations (n = 157, 81%), study drug was interrupted N 3 days (median time of interruption: 18 days, interquartile range 3-30 days); 86 ablations were performed with ≤10 days, and 36 ablations with ≤3 days study drug interruption. During the first 30 days after the ablation, one ischemic stroke was observed in the warfarin group and none in the higher-dose edoxaban regimen (HDER) or lower-dose edoxaban regimen (LDER) group. Three clinically relevant non-major (CRNM) bleeding events were observed in the warfarin group; one major bleed was seen in the HDER group; one minor bleed occurred in the LDER group. All bleeding events occurred among the patients with ≤10 days study drug interruption; in contrast, no ischemic events or deaths were observed in these patients. Conclusions: In this pilot evaluation of the ENGAGE AF-TIMI 48 trial, treatment with edoxaban was associated with a low risk of ischemic and bleeding events during the first 30 days post ablation.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"International Journal of Cardiology","grobid_abstract_attachment_id":89146556},"translated_abstract":null,"internal_url":"https://www.academia.edu/83969121/First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial","translated_internal_url":"","created_at":"2022-07-31T05:38:09.280-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146556,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146556/thumbnails/1.jpg","file_name":"j.ijcard.2017.05.09820220731-1-1os5lz6.pdf","download_url":"https://www.academia.edu/attachments/89146556/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_experience_with_edoxaban_and_atria.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146556/j.ijcard.2017.05.09820220731-1-1os5lz6-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DFirst_experience_with_edoxaban_and_atria.pdf\u0026Expires=1732756866\u0026Signature=QEnMQSasyvJlV8KbNPsUo7ltw3Lm1aWocktdJLm-gbGf7G5t5HR5ie-5voMBVlQ0K2PCET16JALorgolsxYno93-FTjazdZ9TzQ58iJKQOAh85YDVKffziVnFk3c8Hpc5l3qaMoXRGCwxHEjeWdhXykscCkq0myD4pD~o3mtgxHycLRKx0CHhBV21ecOFbYFfLt3zq6BxtRncefG5pc3LEKjI77BShnVL40LASTPryK7OID-RPseTBXJVqjT5ZKVNxotvYuIOUzycFCyFh3K-bSEqpeAWQqfoMxbvdr-EbAnkbGwiFdfJRuKR9VYDfEa4UkjHX4AM9eFuh45CNwN9g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"First_experience_with_edoxaban_and_atrial_fibrillation_ablation_Insights_from_the_ENGAGE_AF_TIMI_48_trial","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146556,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146556/thumbnails/1.jpg","file_name":"j.ijcard.2017.05.09820220731-1-1os5lz6.pdf","download_url":"https://www.academia.edu/attachments/89146556/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_experience_with_edoxaban_and_atria.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146556/j.ijcard.2017.05.09820220731-1-1os5lz6-libre.pdf?1659271507=\u0026response-content-disposition=attachment%3B+filename%3DFirst_experience_with_edoxaban_and_atria.pdf\u0026Expires=1732756866\u0026Signature=QEnMQSasyvJlV8KbNPsUo7ltw3Lm1aWocktdJLm-gbGf7G5t5HR5ie-5voMBVlQ0K2PCET16JALorgolsxYno93-FTjazdZ9TzQ58iJKQOAh85YDVKffziVnFk3c8Hpc5l3qaMoXRGCwxHEjeWdhXykscCkq0myD4pD~o3mtgxHycLRKx0CHhBV21ecOFbYFfLt3zq6BxtRncefG5pc3LEKjI77BShnVL40LASTPryK7OID-RPseTBXJVqjT5ZKVNxotvYuIOUzycFCyFh3K-bSEqpeAWQqfoMxbvdr-EbAnkbGwiFdfJRuKR9VYDfEa4UkjHX4AM9eFuh45CNwN9g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":897823,"name":"Elsevier","url":"https://www.academia.edu/Documents/in/Elsevier"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":22552361,"url":"http://api.elsevier.com/content/article/PII:S0167527317320880?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969120"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969120/Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain"><img alt="Research paper thumbnail of Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain" class="work-thumbnail" src="https://attachments.academia-assets.com/89146555/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969120/Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain">Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain</a></div><div class="wp-workCard_item"><span>European heart journal cardiovascular Imaging</span><span>, Jan 23, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was -16.3 ± 7% in ES, lower compared with healthy controls (P &lt; 0.001) but similar to other PAH aetiologies (P = 0.6). Mean RV peak t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e674b054a47168e2486b8f9e6f3f2400" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146555,"asset_id":83969120,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146555/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969120"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969120"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969120; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969120]").text(description); $(".js-view-count[data-work-id=83969120]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969120; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969120']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969120, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e674b054a47168e2486b8f9e6f3f2400" } } $('.js-work-strip[data-work-id=83969120]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969120,"title":"Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome-implications on survival and the role of right ventricular transverse strain","translated_title":"","metadata":{"abstract":"Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was -16.3 ± 7% in ES, lower compared with healthy controls (P \u0026lt; 0.001) but similar to other PAH aetiologies (P = 0.6). Mean RV peak t...","publication_date":{"day":23,"month":1,"year":2016,"errors":{}},"publication_name":"European heart journal cardiovascular Imaging"},"translated_abstract":"Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was -16.3 ± 7% in ES, lower compared with healthy controls (P \u0026lt; 0.001) but similar to other PAH aetiologies (P = 0.6). Mean RV peak t...","internal_url":"https://www.academia.edu/83969120/Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain","translated_internal_url":"","created_at":"2022-07-31T05:38:09.090-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33098622,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89146555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146555/thumbnails/1.jpg","file_name":"jew277.pdf","download_url":"https://www.academia.edu/attachments/89146555/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_remodelling_amongst_adults_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146555/jew277-libre.pdf?1659271509=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_remodelling_amongst_adults_with.pdf\u0026Expires=1732756866\u0026Signature=MUv5ihcTmGMnD-QqGEUn51ympcayYRMW26jVsiO8RZ2IyJ6Y1p0IklH5cf8MzS~Iwighb3HChGfdBaxTyepI1V0KP9mCPgcU5yZddXxFxBGCLM7zFaS8cyl3Nveut2jyj-Tpvm4J5FtBgDvUugZK1Xrpha4egXlTFUeJnr6l6JDGvUWaQzFM-5xCa~vmG9uA8MrYcHEnV3OUPjrg0Day184qn5Iu7iDm9ve0tZxEOeeeDwOdrr2zcZyyrlpiiywgjabSzaufSaMHY07wB2oGWqgvSqrNN2S0UC6cad0NDXnqeSDAdwAXI99bomqC-G-GWw8Eo0KvytVQoe4-a~b0xA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cardiac_remodelling_amongst_adults_with_various_aetiologies_of_pulmonary_arterial_hypertension_including_Eisenmenger_syndrome_implications_on_survival_and_the_role_of_right_ventricular_transverse_strain","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":33098622,"first_name":"Roxy","middle_initials":"","last_name":"Senior","page_name":"RoxySenior","domain_name":"independent","created_at":"2015-07-15T14:39:12.874-07:00","display_name":"Roxy Senior","url":"https://independent.academia.edu/RoxySenior"},"attachments":[{"id":89146555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89146555/thumbnails/1.jpg","file_name":"jew277.pdf","download_url":"https://www.academia.edu/attachments/89146555/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_remodelling_amongst_adults_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89146555/jew277-libre.pdf?1659271509=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_remodelling_amongst_adults_with.pdf\u0026Expires=1732756866\u0026Signature=MUv5ihcTmGMnD-QqGEUn51ympcayYRMW26jVsiO8RZ2IyJ6Y1p0IklH5cf8MzS~Iwighb3HChGfdBaxTyepI1V0KP9mCPgcU5yZddXxFxBGCLM7zFaS8cyl3Nveut2jyj-Tpvm4J5FtBgDvUugZK1Xrpha4egXlTFUeJnr6l6JDGvUWaQzFM-5xCa~vmG9uA8MrYcHEnV3OUPjrg0Day184qn5Iu7iDm9ve0tZxEOeeeDwOdrr2zcZyyrlpiiywgjabSzaufSaMHY07wB2oGWqgvSqrNN2S0UC6cad0NDXnqeSDAdwAXI99bomqC-G-GWw8Eo0KvytVQoe4-a~b0xA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969119"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969119/Plaque_Neovascularization_Is_Increased_in_Human_Carotid_Atherosclerosis_Related_to_Prior_Neck_Radiotherapy_A_Contrast_Enhanced_Ultrasound_Study"><img alt="Research paper thumbnail of Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study" class="work-thumbnail" src="https://attachments.academia-assets.com/89146569/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969119/Plaque_Neovascularization_Is_Increased_in_Human_Carotid_Atherosclerosis_Related_to_Prior_Neck_Radiotherapy_A_Contrast_Enhanced_Ultrasound_Study">Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study</a></div><div class="wp-workCard_item"><span>JACC. Cardiovascular imaging</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascular...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries. Presence of IPN during contrast-enhanced ultrasound was judged semiquantitatively as grade 0 (absent), grade 1 (present but limited to plaque base), or grade 2 (extensive and noted within plaque body). Of 49 patients studied, 38 (78%) had plaques. The number of plaques was significantly greater in the RT than the non-RT arteries. Overall, 48 of 64 RT-side plaques (75%) had IPN comp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc7d4ac33e4297e25f2b9259d7005ad7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146569,"asset_id":83969119,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146569/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969119"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969119"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969119; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83969119]").text(description); $(".js-view-count[data-work-id=83969119]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83969119; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83969119']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83969119, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dc7d4ac33e4297e25f2b9259d7005ad7" } } $('.js-work-strip[data-work-id=83969119]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83969119,"title":"Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study","translated_title":"","metadata":{"abstract":"The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries. Presence of IPN during contrast-enhanced ultrasound was judged semiquantitatively as grade 0 (absent), grade 1 (present but limited to plaque base), or grade 2 (extensive and noted within plaque body). Of 49 patients studied, 38 (78%) had plaques. The number of plaques was significantly greater in the RT than the non-RT arteries. Overall, 48 of 64 RT-side plaques (75%) had IPN comp...","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"JACC. Cardiovascular imaging"},"translated_abstract":"The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries. Presence of IPN during contrast-enhanced ultrasound was judged semiquantitatively as grade 0 (absent), grade 1 (present but limited to plaque base), or grade 2 (extensive and noted within plaque body). Of 49 patients studied, 38 (78%) had plaques. The number of plaques was significantly greater in the RT than the non-RT arteries. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969118"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969118/Insulin_induced_hypoglycaemia_and_the_detection_of_myocardial_injury_using_an_ultrasensitive_troponin_assay"><img alt="Research paper thumbnail of Insulin-induced hypoglycaemia and the detection of myocardial injury using an ultrasensitive troponin assay" class="work-thumbnail" src="https://attachments.academia-assets.com/89146554/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969118/Insulin_induced_hypoglycaemia_and_the_detection_of_myocardial_injury_using_an_ultrasensitive_troponin_assay">Insulin-induced hypoglycaemia and the detection of myocardial injury using an ultrasensitive troponin assay</a></div><div class="wp-workCard_item"><span>International Journal of Cardiology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9cc7d969c5322db6436c981a4fe4003" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146554,"asset_id":83969118,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146554/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969118"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969118"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969118; 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969114/Left_atrial_enlargement_causing_dysphagia_and_weight_loss_a_rare_contraindication_for_catheter_ablation_therapy_in_a_patient_with_complex_atrial_arrhythmia"><img alt="Research paper thumbnail of Left atrial enlargement causing dysphagia and weight loss: a rare contraindication for catheter ablation therapy in a patient with complex atrial arrhythmia" class="work-thumbnail" src="https://attachments.academia-assets.com/89146549/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969114/Left_atrial_enlargement_causing_dysphagia_and_weight_loss_a_rare_contraindication_for_catheter_ablation_therapy_in_a_patient_with_complex_atrial_arrhythmia">Left atrial enlargement causing dysphagia and weight loss: a rare contraindication for catheter ablation therapy in a patient with complex atrial arrhythmia</a></div><div class="wp-workCard_item"><span>International journal of cardiology</span><span>, Jan 20, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="20ec84c4f9137016cd57cbcb95e834b5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146549,"asset_id":83969114,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146549/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969113/Myocardial_Viability_Comparison_with_Other_Imaging_Techniques"><img alt="Research paper thumbnail of Myocardial Viability: Comparison with Other Imaging Techniques" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969113/Myocardial_Viability_Comparison_with_Other_Imaging_Techniques">Myocardial Viability: Comparison with Other Imaging Techniques</a></div><div class="wp-workCard_item"><span>Contrast Echocardiography in Clinical Practice</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Myocardial viability may be defined as myocardium with preserved metabolic, cel lular and membran...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Myocardial viability may be defined as myocardium with preserved metabolic, cel lular and membrane function which allows the myocardium to maintain its contractile function. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83969112"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83969112/Diagnosis_of_coronary_artery_disease_in_heart_failure_Role_of_myocardial_contrast_echocardiography_in_patients_with_first_presentation_of_heart_failure_not_due_to_acute_myocardial_infarction"><img alt="Research paper thumbnail of Diagnosis of coronary artery disease in heart failure: Role of myocardial contrast echocardiography in patients with first presentation of heart failure not due to acute myocardial infarction" class="work-thumbnail" src="https://attachments.academia-assets.com/89146552/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83969112/Diagnosis_of_coronary_artery_disease_in_heart_failure_Role_of_myocardial_contrast_echocardiography_in_patients_with_first_presentation_of_heart_failure_not_due_to_acute_myocardial_infarction">Diagnosis of coronary artery disease in heart failure: Role of myocardial contrast echocardiography in patients with first presentation of heart failure not due to acute myocardial infarction</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="53be6559804ff3c2cfd537832a359cad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89146552,"asset_id":83969112,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89146552/download_file?st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1MzI2Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83969112"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83969112"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83969112; 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