Michael Alexanian | Gladstone Institutes

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href="/giving" class="sf-depth-1">Give</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </header> </div> <div id="page-start" class="clearfix page-start"></div> <a name="main-content"></a> <div class="system-messages clearfix"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="region region-system-messages"> <div data-drupal-messages-fallback class="hidden"></div> <div class="views-element-container clearfix block block-views block-views-blockuser-admin-people-investigator-profile-name" id="block-views-block-user-admin-people-investigator-profile-name"> <div class="content"> <div><div class="view view-user-admin-people view-id-user_admin_people view-display-id-investigator_profile_name js-view-dom-id-bc83c8be8d837324c1e17f4bb916ea6111392539ce61fc6fb0124343a9573735"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-last-name"><div class="field-content"><h1 class="page-title">Michael Alexanian, PhD </h1></div></div><div class="views-field views-field-field-division"><div class="field-content"><a class="inst1" href="/science/cardiovascular-disease-institute">Gladstone Institute of Cardiovascular Disease</a></div></div></div> </div> <div class="view-footer"> <script> let myElement = document.getElementById("inst3"); if (myElement.classList.contains("inst3")) { var style = document.createElement('style'); style.innerHTML = ` .investigator .system-messages {margin-top: 167px;} @media (max-width: 991px) { .investigator .system-messages { margin-top: 100px; } } `; document.head.appendChild(style); } </script> <style> h1.page-title {text-transform:uppercase} .inst1,.inst2,.inst3 {display:block} .inst2,.inst1 {padding-bottom:4px} @media (max-width: 600px) { .inst2, .inst3{display:none !important;} } </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix main-content region--dark-typography region--white-background region--no-separator"> <div class="clearfix main-content__container"> <div class="row"> <section> <div class="clearfix main-content__section" > <div class="region region-content"> <div id="block-showcase-lite-content" class="clearfix block block-system block-system-main-block"> <div class="content"> <article class="user user--full"> <div id="subtabs" class="subtabs"> <ul class="sudonav"> <li class="tab"><a href="#research" ><span>Research</span></a></li> <li class="tab"><a href="#about" ><span>About</span></a></li> <li class="tab"><a href="#publications" ><span>Publications</span></a></li> <li class="tab"><a href="#contact" ><span>Contact</span></a></li>  </ul> <div class="content-wrap"> <section id="research"> <div class="container"> <div class="clearfix text-formatted field field--name-field-overview field--type-text-long field--label-hidden field__item"><p>Michael Alexanian鈥檚 lab is interested in understanding the genetic and epigenetic mechanisms that govern cell identity in health and disease, with a particular focus on heart disease. In the setting of heart failure, stress induces changes that activate a subset of heart cells, altering their form and function and promoting disease progression. The Alexanian Lab is interested in dissecting the gene-level changes that underlie this effect, in order to design targeted therapies to preserve or restore heart function.</p> </div> <div id="dis-tise" class="row"> <div class="col-sm-6"> <h3 class="orange">Disease Areas</h3> <div class="field field--name-field-disease-area field--type-string field--label-hidden field__items"> <div class="field__item">Heart Failure</div> <div class="field__item">Fibrosis</div> <div class="field__item">Inflammation</div> </div> </div> <div class="col-sm-6"> <h3 class="orange">Areas of Expertise</h3> <div class="field field--name-field-areas-of-expertise field--type-string field--label-hidden field__items"> <div class="field__item">Chromatin and Gene Regulation</div> <div class="field__item">Epigenomics</div> <div class="field__item">Single-Cell Transcriptomics</div> <div class="field__item">Heart Physiology</div> <div class="field__item">Non-Coding RNAs</div> </div> </div> </div> </div> <div class="lab-focus"> <div class="focus-img-bk"> <div class="focus-image"> <img src="/sites/default/files/user-pics/alexanian_labfocus.jpg" alt="Working in the Alexanian lab" /> </div> </div> <div class="focus-points"> <h3>Lab Focus</h3> <div class="field field--name-field-lab-focus field--type-string-long field--label-hidden field__items"> <div class="field__item">Deciphering the epigenomic mechanisms governing cellular plasticity in adult tissue.</div> <div class="field__item">Understanding the role of cell-cell communication during progression and reversal of heart failure.</div> <div class="field__item">Identifying therapeutic targets to preserve or restore cardiac function following heart failure.</div> </div> </div> </div> <div class="container"> <div class="impact"> <h3>Research Impact</h3> <div class="clearfix text-formatted field field--name-field-research-impact field--type-text-long field--label-hidden field__item"><p>Alexanian鈥檚 work provides deep mechanistic insight into the epigenomic basis of cellular plasticity in heart disease. Most recently, his research revealed the mechanism underlying the beneficial effect of small molecule bromodomain inhibitors in heart failure, demonstrating that rather than affecting cardiomyocytes, the drugs control the activation of fibroblasts, with direct impact on cardiac function.</p> <p>The Alexanian Lab studies how chromatin receives, processes, and amplifies environmental stress signals that drive changes in cell states leading to human diseases such as heart failure. The team鈥檚 long-term goal is to contribute to the understanding of how to target gene regulation in a cell-specific manner to treat heart disease.</p> </div> </div> </div> <div> </div> <div id="related-news"> <div class="container"> <h2>Related News</h2> <div class="button-right"><a href="/news?categories=Alexanian%20lab" class="button outline" tabindex="-1">Read All</a></div> <div id="owl" class="owl-carousel"> </div> </div> </div> </section> <section id="about"> <div class="container"> <div class="prof-titles"> <h3>Professional Titles</h3> <p>Assistant Investigator, Gladstone Institutes</p> <p>Dario and Irina Sattui Investigator in Cardiac Fibrosis, Gladstone Institutes</p> <p>Assistant Professor, Department of Pediatrics, UC San Francisco</p> </div> <h3>Bio</h3> <div class="clearfix text-formatted field field--name-field-bio field--type-text-long field--label-hidden field__item"><p>Michael Alexanian, PhD, is an assistant investigator at Gladstone Institutes and an assistant professor in pediatrics at UC San Francisco.</p> <p>Alexanian received his bachelor鈥檚 and Master's degrees from the University of Florence in Italy. After he graduated, Alexanian spent several months at the Walter and Eliza Hall Institute in Melbourne, Australia, working with epigenomics expert Marnie Blewitt. Alexanian returned to Europe for a graduate degree in stem cell biology at the University of Lausanne in Switzerland in the lab of Thierry Pedrazzini. During his doctoral studies, he investigated the role of non-coding RNAs, including transcribed enhancers and long non-coding RNAs in pluripotency and early cell fate specification. During his postdoctoral work at Gladstone under the supervision of Deepak Srivastava and Saptarsi Haldar, Alexanian discovered gene programs related to cellular plasticity in the context of heart failure.</p> </div> <div class="why-gladstone"> <h3>How Did You Get Your Start in Science?</h3> <p>When I realized that the human genome has fewer than 30,000 protein-coding genes, I was fascinated that biological sophistication evolves through the development of finely regulated gene expression mechanisms, rather than a sheer increase in the number of genes鈥攁nd it shaped my desire to pursue my career as a molecular biologist.</p> </div> <div class="why-who"> Michael Alexanian, PhD </div> <h3>Honors and Awards</h3> <div class="honors-awards"> <p class="item-1 firstWord">2021 Distinguished Achievement in Cardiovascular Research, Gladstone Institutes</p> <div class="cntrbutt"><a class="moreawards button outline">See More</a></div> </div> </div> </section> <section id="publications"> <div class="container"> <h3>Publications</h3> <ul id="datalist"> <div id="pubitem"></div> <script> const RSS_URL = `https://fetchrss.com/rss/6102d5027b14d422fa7206b2630fdf4ca4cf201701651d82.xml`; const pubitem = document.getElementById("pubitem"); fetch(RSS_URL) .then(response => response.text()) .then(str => new window.DOMParser().parseFromString(str, "text/xml")) .then(data => { console.log(data); const items = data.querySelectorAll("item"); let html = ``; items.forEach(el => { pubitem.innerHTML += `<li><a href="${el.querySelector("link").innerHTML}" target="_blank">${el.querySelector("title").innerHTML}</a><br> ${el.querySelector("description").innerHTML.replace("]]>"," ")}</li>`; }); }); </script> <div id="morebutt"><a href="https://scholar.google.com/citations?user=BkvkpVQAAAAJ&hl=en" target="_blank">More Publications</a></div> <style> .pubitem {margin-bottom:24px; font-family: 'Proxima-Nova', Sans-serif !important;line-height: 1.4 !important; font-weight: 300 !important;font-size:24px !important; color:#002A40 !important;} .pubitem a {color: #cc29A4;font-weight:400; text-decoration:none} #morebutt{text-align:center;margin-top:90px; margin-bottom:90px} #morebutt a {border-radius: 40px;border: 1px solid #002A40; color: #002A40; cursor: pointer; padding: 14px 26px; font-weight: bold !important; outline: none; text-transform: uppercase; font: initial; font-family: 'Proxima-Nova',Sans-serif; font-size: 14px; letter-spacing: 2px; text-decoration: none !important; white-space: nowrap; transition: all .5s ease;} #morebutt a:hover{background: #C8C8C8;} @media (max-width: 991px) { .pubitem, .gs_gray {font-size:20px !important} } </style> </ul> </div> </section> <section id="contact"> <div class="container"> <h3> Contact</h3> <div class="row"> <div class="col-sm-7"> <p class="to-hide"><b>Michael Alexanian</b><br> <a href="mailto:michael.alexanian@gladstone.ucsf.edu">Email</a><br> <a href="tel:415.734.4885" title="Call" class="ph-link inv-phone">415.734.4885</a></p> <div class="investigator-assistants"> <article class="user user--compact"> <div class="user__compact"> <p> <b>Emma Straight</b><br>Administrative Assistant<br> <a href="tel:415.734.2705" title="Call" class="ph-link">415.734.2705</a><br> <a href="mailto:emma.straight@gladstone.ucsf.edu">Email</a> </p> </div> </article> <br> </div> </div> <div class="col-sm-5" > <p class="labsite"> <a href="https://michaelalexanianlab.com/" class="button magenta" target="_blank">Alexanian Lab Website</a> </p> <table class="relatedlinks"><tr> <tr><td colspan=2><a href="https://twitter.com/m_alexanian" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i> Twitter</a></td> </tr> <tr><td colspan=2><a href="https://www.linkedin.com/in/michael-alexanian-0b0090168/" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i> LinkedIn</a></td> </tr> <link rel="stylesheet" href="/themes/custom/showcase_lite/css/theme/academicons/css/academicons.min.css"> <tr><td colspan=2><a href="https://scholar.google.com/citations?user=BkvkpVQAAAAJ&hl=en&oi=ao" target="_blank"><i class="ai ai-google-scholar"></i> Google Scholar</a></td> </tr> </table> </div> </div> </div> </section> <section id="labmembers"> <div class="container"> <div class="prof-titles"> <h3>Lab Members</h3> </div> <div class="row"> <div class="item"><div class="blowpic">Junedh Amrute, PhD <br><div class="lmtitle">Visiting Scientist</div><div class="la-mail"><script>user = "Junedh.Amrute";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Yuqian An, PhD <br><div class="lmtitle">Postdoctoral Scholar</div><div class="la-mail"><script>user = "Yuqian.An";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Kirsten Auclair<br><div class="lmtitle"></div><div class="la-mail"><script>user = "Kirsten.Auclair";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Kirsten Auclair<br><div class="lmtitle">Collaborator</div><div class="la-mail"><script>user = "Kirsten.Auclair";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Rangarajan Nadadur<br><div class="lmtitle">Visiting Postdoc</div><div class="la-mail"><script>user = "Rangarajan.Nadadur";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Vivek Nalluri<br><div class="lmtitle">Student Intern</div><div class="la-mail"><script>user = "Vivek.Nalluri";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Pawel Przytycki, PhD <br><div class="lmtitle">Collaborator</div><div class="la-mail"><script>user = "Pawel.Przytycki";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Stephen Wu<br><div class="lmtitle">Student Intern</div><div class="la-mail"><script>user = "Stephen.Wu";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Vee Xu<br><div class="lmtitle">Research Engineer I</div><div class="la-mail"><script>user = "Vee.Xu";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Ada Zhu<br><div class="lmtitle">Research Associate I</div><div class="la-mail"><script>user = "Ada.Zhu";site = 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