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Saturday, November 23, 2024</div><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_SCIENCE" target="_blank" href="https://www.bioworld.com/womens_health">Breaking News: Healing a health divide (that’s long overdue)</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/517055-try-bioworld-for-free-for-two-weeks">Breaking News: Try BioWorld for free for two weeks</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/517055-try-bioworld-for-free-for-two-weeks">Breaking News: Try BioWorld for free for two weeks</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/714414-duchembio-files-for-ipo-to-grow-radiopharma-business">Breaking News: Duchembio files for IPO to grow radiopharma business</a></section><section class="featured-stories__wrapper -primary-3 --secondary-5"><div class="featured-stories__primary "><section class="featured-stories "> <div class="featured-stories__items-wrapper"><ul class="featured-stories__items featured-stories__items-1"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><figure class="featured-stories__image"><a class="featured-stories__thumbnail-link" data-eventname="featured-stories" data-eventcategory="click" data-eventaction="featured-stories-image" data-eventlabel="https://www.bioworld.com/articles/714726-epigenetic-changes-linked-to-weight-regain" href="https://www.bioworld.com/articles/714726-epigenetic-changes-linked-to-weight-regain"><img class="featured-stories__image-thumb" alt="Illustration for yo-yo diet" title="Illustration for yo-yo diet" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Obesity/Weight-loss-yo-yo-cycle.jpg?height=355&t=1732292895&width=640" /></a></figure><div class="featured-stories__details featured-stories__details-1"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714726-epigenetic-changes-linked-to-weight-regain"> Epigenetic changes linked to weight regain</a></h1><div class="featured-stories__teaser">Fat cells from patients who had lost weight after bariatric surgery, as well as from animals who had gained and then lost weight, were transcriptionally distinct from cells that had not experienced such weight changes at the organism level. In the animal studies, those transcriptional changes were due to epigenetic changes. The findings, which were published online in <em>Nature</em> on Nov. 18, 2024, are a possible molecular-level explanation for the short-term nature of most weight loss.</div></div></article> </li> </ul><ul class="featured-stories__items featured-stories__items-2"> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714727-edp-514-demonstrates-favorable-preclinical-pk-profile-excellent-target-tissue-penetration">EDP-514 demonstrates favorable preclinical PK profile, excellent target tissue penetration</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714729-protagonist-therapeutics-selects-il-17-antagonist-as-development-candidate">Protagonist Therapeutics selects IL-17 antagonist as development candidate</a></h1></article> </li> </ul></div> </section></div><div class="featured-stories__secondary"><section class="featured-stories "> <ul class="featured-stories__items"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714726-epigenetic-changes-linked-to-weight-regain"> Epigenetic changes linked to weight regain</a></h1><div class="featured-stories__teaser">Fat cells from patients who had lost weight after bariatric surgery, as well as from animals who had gained and then lost weight, were transcriptionally distinct from cells that had not experienced such weight changes at the organism level. In the animal studies, those transcriptional changes were due to epigenetic changes. The findings, which were published online in <em>Nature</em> on Nov. 18, 2024, are a possible molecular-level explanation for the short-term nature of most weight loss.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714727-edp-514-demonstrates-favorable-preclinical-pk-profile-excellent-target-tissue-penetration">EDP-514 demonstrates favorable preclinical PK profile, excellent target tissue penetration</a></h1><div class="featured-stories__teaser">Enanta Pharmaceuticals Inc. has released preclinical pharmacokinetics (PK) data for EDP-514, a potent and selective class II core assembly modulator in phase I development for the oral treatment of hepatitis B.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714729-protagonist-therapeutics-selects-il-17-antagonist-as-development-candidate">Protagonist Therapeutics selects IL-17 antagonist as development candidate</a></h1><div class="featured-stories__teaser">Protagonist Therapeutics Inc. has selected PN-881, an oral peptide interleukin-17 (IL-17) antagonist, as a development candidate for the treatment of immune-mediated skin diseases.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/712279-other-news-to-note-for-nov-22-2024">Other news to note for Nov. 22, 2024</a></h1><div class="featured-stories__teaser">Additional early-stage research and drug discovery news in brief.</div></article> 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obesity</a></h1><div class="featured-stories__teaser">Startup company Pep2tango Therapeutics Inc., unveiled with backing by Versant Ventures, is advancing unimolecular multireceptor peptide agonists that target GLP-1, GIP, amylin and calcitonin receptors.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714732-transposon-therapeutics-acquires-nucleoside-analogues-for-cancer-from-primefour">Transposon Therapeutics acquires nucleoside analogues for cancer from Primefour</a></h1><div class="featured-stories__teaser">Transposon Therapeutics Inc. has acquired a portfolio of novel nucleoside analogues from Primefour Therapeutics Inc. for the targeted treatment of pancreatic cancer, certain other solid tumors and hematologic cancers.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/714733-b7-h3-cd28-bispecific-antibody-enhances-t-cell-engager-immunotherapies">B7-H3/CD28 bispecific antibody enhances T-cell engager immunotherapies </a></h1><div class="featured-stories__teaser">Researchers from Xencor Inc. described the preclinical characterization of XmAb-808.</div></article> </li> </ul> </section></div><div class="news-service articles-by-site-placement-tax"><section class="featured-stories-by-site-placement__wrapper"><section class="featured-stories-by-site-placement "> <div class="featured-stories-by-site-placement__items-wrapper"><ul class="featured-stories-by-site-placement__items featured-stories-by-site-placement__items-1"> <li class="featured-stories-by-site-placement__item"> <article 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immuno-corrective therapy for autoimmune diseases</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/714736-hm-17321-a-crfr2-selective-ucn2-analogue-with-efficacy-in-models-of-obesity">HM-17321, a CRFR2-selective UCN2 analogue with efficacy in models of obesity</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 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href="https://clarivate.com/life-sciences-healthcare/bioworld/order/" target="_blank"><img src="https://www.bioworld.com/ext/resources/Ads/2024/Focus-25-EOY-offer2.jpg"></a></div><section class="bioworld-podcasts-component"><div class="bioworld-podcasts-component__wrapper"><div class="bioworld-podcasts-component__content"><h3 class="bioworld-podcasts-component__headline"><a class="bioworld-podcasts-component__headline-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/53-healing-the-health-divide-for-women">BioWorld Insider Podcast</a></h3><div class="bioworld-podcasts-component__body"><img src="https://www.bioworld.com/ext/resources/Podcast-files/play-circle-button.png?1718131949" style="display: inline-block; vertical-align: bottom; margin: 5px 0px 5px 5px; text-align: right; float: right; max-width: calc(100% - 5px); width: 95px;" alt="Play button" data-uuid="YTAtMTE1OTM1" align="right">Karen Carey, <em>BioWorld</em>’s managing editor and chief analyst, and the managing editor of <em>Bioworld Science</em>, Anette Breindl, join this episode of the <em>BioWorld Insider</em> podcast to talk about the business and the science of women’s health.</div><a class="bioworld-podcasts-component__link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/53-healing-the-health-divide-for-women">Listen now</a></div></div></section></div><section class="topics-section__wrapper"><div class="topics-section__primary"><section class="topics-section "> <h1 class="topics-section__title"><a class="topics-section__title-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-title" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">Conferences</a></h1><ul class="topics-section__items"> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/714706-etx-258-improves-cardiac-function-and-structural-remodeling-post-mi" href="https://www.bioworld.com/articles/714706-etx-258-improves-cardiac-function-and-structural-remodeling-post-mi"><img class="topics-section__image-thumb" alt="Human heart within crosshairs" title="Human heart within crosshairs" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/heart-failure-attack-target.jpg?height=355&t=1715782430&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714706-etx-258-improves-cardiac-function-and-structural-remodeling-post-mi">ETX-258 improves cardiac function and structural remodeling post-MI</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/164,520">American Heart Association Scientific Sessions</a></div><div class="topics-section__teaser">At the American Heart Association’s Scientific Sessions, E-Therapeutics plc presented preclinical data for ETX-258, a Galomic siRNA being developed for the treatment of heart failure.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/714712-hoxb13-gene-involved-in-metastatic-omentum-carcinoma-study-shows" href="https://www.bioworld.com/articles/714712-hoxb13-gene-involved-in-metastatic-omentum-carcinoma-study-shows"><img class="topics-section__image-thumb" alt="DNA mutations or genetic disorder concept art" title="DNA mutations or genetic disorder concept art" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/DNA-gene-damage-mutation.jpg?height=355&t=1711552096&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714712-hoxb13-gene-involved-in-metastatic-omentum-carcinoma-study-shows">HOXB13 gene involved in metastatic omentum carcinoma, study shows</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/543,520">Biomarkers</a></div><div class="topics-section__teaser">Primary tumors arising in the gastrointestinal system, ovary or pancreas may spread and lead to secondary cancers such as metastatic omentum cancer.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714697-linoleic-acid-metabolite-reduces-atrial-arrhythmia-by-normalizing-camkii-levels">Linoleic acid metabolite reduces atrial arrhythmia by normalizing CaMKII levels</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/164,520">American Heart Association Scientific Sessions</a></div><div class="topics-section__teaser">Researchers from Ohio State University hypothesized that 12,13-diHOME may act by inhibiting the proarrhythmic molecule Ca2+/calmodulin-dependent kinase II (CaMKII).</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/714696-gileads-gs-6791-ameliorates-arthritis-symptoms-in-mice" href="https://www.bioworld.com/articles/714696-gileads-gs-6791-ameliorates-arthritis-symptoms-in-mice"><img class="topics-section__image-thumb" alt="Joint pain " title="Joint pain " width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Inflammatory/Joint-pain2.png?height=355&t=1642802876&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/714696-gileads-gs-6791-ameliorates-arthritis-symptoms-in-mice">Gilead’s GS-6791 ameliorates arthritis symptoms in mice</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/162,520">American College of Rheumatology</a></div><div class="topics-section__teaser">Interleukin-1 receptor-associated kinase 4 is critical in the modulation of inflammatory responses through Toll-like receptor and IL-1R signaling.</div></div></article> </li> </ul><a class="topics-section__more-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-more-link" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">More in Conferences</a> </section></div><div class="topics-section__aside"><section class="news-in-brief "> <h1 class="news-in-brief__title">Today's news in brief</h1><ul class="news-in-brief__items"> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/714744-other-news-to-note-for-nov-22-2024">Other news to note for Nov. 22, 2024</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689316-respiratory">Respiratory</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689317-dermatologic">Dermatologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689318-cardiovascular">Cardiovascular</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689319-hematologic">Hematologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689320-nephrology">Nephrology</a></h1></article> </li> </ul> </section></div></section><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/472-patents" href="/articles/topic/472-patents">Patents</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714719-evotec-designs-new-47-antagonists">Evotec designs new α4β7 antagonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714718-roche-reports-cd73-inhibitors-for-cancer">Roche reports CD73 inhibitors for cancer</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714717-gruenenthal-describes-new-nociceptin-receptor-agonists-for-pain">Gruenenthal describes new nociceptin receptor agonists for pain</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714716-janssen-patent-discloses-new-compounds-for-mycobacterial-infections">Janssen patent discloses new compounds for mycobacterial infections</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714715-sanofi-patents-new-mapk7-inhibitors-for-cancer">Sanofi patents new MAPK7 inhibitors for cancer</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714609-horizon-omics-biotech-prepares-new-quinolone-derivatives">Horizon Omics Biotech prepares new quinolone derivatives</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714608-shanghai-synergy-and-zhejiang-huahai-synthesize-new-ccr4-antagonists">Shanghai Synergy and Zhejiang Huahai synthesize new CCR4 antagonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714607-hansoh-pharma-patent-develops-cfb-inhibitors">Hansoh Pharma patent develops CFB inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714606-korea-research-institute-of-chemical-technology-and-novartis-identify-new-antiviral-compounds">Korea Research Institute of Chemical Technology and Novartis identify new antiviral compounds</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714605-aeovian-pharmaceuticals-patents-new-cd38-inhibitors">Aeovian Pharmaceuticals patents new CD38 inhibitors</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">Cancer</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/714698-eg-011-exerts-robust-antiproliferative-activity-in-hematological-cancer-models" href="https://www.bioworld.com/articles/714698-eg-011-exerts-robust-antiproliferative-activity-in-hematological-cancer-models"><img class="bioworld-biome__image-thumb" alt="Art concept for hematologic cancer" title="Art concept for hematologic cancer" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/leukemia-lymphoma-blood-cancer.jpg?height=355&t=1724424490&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714698-eg-011-exerts-robust-antiproliferative-activity-in-hematological-cancer-models">EG-011 exerts robust antiproliferative activity in hematological cancer models </a></h1><div class="bioworld-biome__teaser">The Wiskott-Aldrich syndrome protein (WASp) is expressed exclusively in hematopoietic cells and presents either an autoinhibited or activated conformation. EG-011 is a first-in-class activator of the autoinhibited form of WASp designed for the treatment of hematological cancers.</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714602-lbl-042-a-bispecific-antibody-targeting-pd-1-and-lilrb1-2-that-can-overcome-resistance-to-pd-1-monotherapy">LBL-042, a bispecific antibody targeting PD-1 and LILRB1/2 that can overcome resistance to PD-1 monotherapy</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714604-gsc-000829-a-selective-fgfr2-fgfr3-inhibitor-for-cancer-therapy">GSC-000829, a selective FGFR2/FGFR3 inhibitor, for cancer therapy</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714597-dan-222-demonstrates-efficacy-in-pediatric-solid-tumor-models">DAN-222 demonstrates efficacy in pediatric solid tumor models</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714594-onc-206-shows-potential-to-prevent-colorectal-cancer-recurrences">ONC-206 shows potential to prevent colorectal cancer recurrences</a></h1></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">More in Cancer</a> </section></div><div class="advertisement topics-section-2__col -two"><a href="https://clarivate.com/contact-us/sales-enquiries/" target="_blank"><img src="https://www.bioworld.com/ext/resources/Ads/2024/bioworld-advertising-reach.jpg" style="width: 300px; height: 250px;"></a></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">Infection</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/714601-epigenic-therapeutics-epigenetic-inactivator-cleared-to-enter-clinic-for-chronic-hepatitis-b" href="https://www.bioworld.com/articles/714601-epigenic-therapeutics-epigenetic-inactivator-cleared-to-enter-clinic-for-chronic-hepatitis-b"><img class="clinical__image-thumb" alt="Hepatitis B virus rendering" title="Hepatitis B virus rendering" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Hepatitis-B-virus-CC-by-2-0.jpg?height=355&t=1732117087&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714601-epigenic-therapeutics-epigenetic-inactivator-cleared-to-enter-clinic-for-chronic-hepatitis-b">Epigenic Therapeutics’ epigenetic inactivator cleared to enter clinic for chronic hepatitis B</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/402,520">Regulatory</a></div><div class="clinical__teaser">Epigenic Therapeutics Inc. has received clinical trial application (CTA) approval from the New Zealand Medicines and Medical Devices Safety Authority (Medsafe) and the Health and Disability Ethics Committees (HDEC) to initiate a clinical trial for EPI-003, an investigational, liver-targeting...</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714579-gilead-discloses-gs-441524-prodrugs-for-treatment-of-viral-infections">Gilead discloses GS-441524 prodrugs for treatment of viral infections</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="clinical__teaser">Gilead Sciences Inc. has synthesized 4-aminopyrrolo[2,1-F][1,2,4]triazine C-nucleoside analogues acting as prodrugs of GS-441524 and reported to be useful for the treatment of viral infections.</div></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714475-greek-scientists-patent-new-spike-glycoprotein-ace2-interaction-inhibitors-for-sars-cov-2">Greek scientists patent new spike glycoprotein/ACE2 interaction inhibitors for SARS-CoV-2</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/517,520">Coronavirus</a></div><div class="clinical__teaser">A group of researchers have disclosed spike glycoprotein (SARS-CoV-2; COVID-19 virus)/ACE2 interaction inhibitors in a new patent.</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714354-arcturus-gains-ind-clearance-for-h5n1-influenza-sa-rna-vaccine-candidate">Arcturus gains IND clearance for H5N1 influenza sa-RNA vaccine candidate</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/402,520">Regulatory</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714367-ifast-raises-65m-for-technology-to-fight-antimicrobial-resistance">Ifast raises $6.5M for technology to fight antimicrobial resistance</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/292,520">Financings</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714245-westlake-pharmaceutical-discloses-new-mpro-inhibitors">Westlake Pharmaceutical discloses new Mpro inhibitors</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/517,520">Coronavirus</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714237-tonix-presents-new-data-on-tnx-801-mpox-vaccine">Tonix presents new data on TNX-801 mpox vaccine</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">More in Infection</a> </section></div></div></section><div class="deals-m-a__wrapper"><section class="deals-m-a "> <h1 class="deals-m-a__title"><a class="deals-m-a__title-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-title" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">Neurology/psychiatric</a></h1><ul class="deals-m-a__items"> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/714687-voyager-therapeutics-to-advance-tau-silencing-gene-therapy-for-alzheimers-disease" href="https://www.bioworld.com/articles/714687-voyager-therapeutics-to-advance-tau-silencing-gene-therapy-for-alzheimers-disease"><img class="deals-m-a__image-thumb" alt="Illustration of tau proteins in Alzheimer's disease" title="Illustration of tau proteins in Alzheimer's disease" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Alzheimer-disease-Tau-proteins.png?height=355&t=1678376665&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714687-voyager-therapeutics-to-advance-tau-silencing-gene-therapy-for-alzheimers-disease">Voyager Therapeutics to advance tau silencing gene therapy for Alzheimer’s disease</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/278,520">Gene therapy</a></div><div class="deals-m-a__teaser">Voyager Therapeutics Inc. has selected a lead development candidate, VY-1706, for its tau silencing gene therapy program in Alzheimer’s disease. The company anticipates filing an IND application with the FDA and a clinical trial application (CTA) with Health Canada for VY-1706 in 2026.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/714600-ractigen-therapeutics-rag-21-designated-orphan-drug-for-als" href="https://www.bioworld.com/articles/714600-ractigen-therapeutics-rag-21-designated-orphan-drug-for-als"><img class="deals-m-a__image-thumb" alt="Illustration of siRNA structure" title="Illustration of siRNA structure" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/siRNA-structure-model.jpg?height=355&t=1732119622&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714600-ractigen-therapeutics-rag-21-designated-orphan-drug-for-als">Ractigen Therapeutics’ RAG-21 designated orphan drug for ALS</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/402,520">Regulatory</a></div><div class="deals-m-a__teaser">Ractigen Therapeutics Co. Ltd.’s RAG-21, a novel siRNA therapy targeting the FUS gene, has been awarded orphan drug designation by the FDA for the treatment of amyotrophic lateral sclerosis (ALS).</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714599-sangamos-st-503-receives-ind-clearance-for-idiopathic-small-fiber-neuropathy">Sangamo’s ST-503 receives IND clearance for idiopathic small fiber neuropathy</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/402,520">Regulatory</a></div><div class="deals-m-a__teaser">Sangamo Therapeutics Inc. has received IND clearance from the FDA for ST-503, an investigational epigenetic regulator for the treatment of intractable pain due to idiopathic small fiber neuropathy (iSFN).</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/714595-lilly-to-develop-als-therapeutics-against-targets-identified-under-verge-collaboration" href="https://www.bioworld.com/articles/714595-lilly-to-develop-als-therapeutics-against-targets-identified-under-verge-collaboration"><img class="deals-m-a__image-thumb" alt="Degradation of motor neurons" title="Degradation of motor neurons" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Degradation-of-motor-neurons.png?height=355&t=1675459347&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714595-lilly-to-develop-als-therapeutics-against-targets-identified-under-verge-collaboration">Lilly to develop ALS therapeutics against targets identified under Verge collaboration </a></h1><div class="deals-m-a__teaser">Eli Lilly & Co. has elected to pursue the development of therapeutics against two validated drug targets for amyotrophic lateral sclerosis (ALS) from its collaboration with Verge Analytics Inc. (dba Verge Genomics).</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/714576-verge-analytics-patents-new-pikfyve-inhibitors">Verge Analytics patents new PIKfyve inhibitors</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Verge Analytics Inc. (dba Verge Genomics) has prepared and tested new hydrazone and pyrazole 3<em>H</em>-imidazo(4,5-<em>b</em>)pyridine compounds acting as 1-phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) inhibitors.</div></div></article> </li> </ul><a class="deals-m-a__more-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-more-link" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">More in Neurology/psychiatric</a> </section></div><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/250-immune" href="/articles/topic/250-immune">Immune</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714679-more-than-100m-cells-included-in-the-human-cell-atlas">More than 100M cells included in the human cell atlas</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714520-research-supports-ccn1-as-a-therapeutic-target-in-rheumatoid-arthritis">Research supports CCN1 as a therapeutic target in rheumatoid arthritis</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714550-despite-womens-health-inroads-lackluster-funding-impedes-progress">Despite women’s health inroads, lackluster funding impedes progress</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714429-the-science-of-gender-based-medicine-many-reasons-many-manifestations">The science of gender-based medicine: many reasons, many manifestations</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714386-cspcs-hpv-mrna-vaccine-candidate-cleared-to-enter-clinic-in-china">CSPC’s HPV mRNA vaccine candidate cleared to enter clinic in China</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714322-md-anderson-announces-new-institute-for-cell-therapy-discovery-and-innovation">MD Anderson announces new Institute for Cell Therapy Discovery & Innovation</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714202-oblenio-to-develop-tri-specific-t-cell-engager-for-autoimmune-diseases">Oblenio to develop tri-specific T-cell engager for autoimmune diseases</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714173-biofuture-2024-half-the-populations-health-needs-are-underserved">BioFuture 2024: Half the population’s health needs are underserved</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714145-mpo-inhibition-yields-protective-efficacy-in-mpo-anca-autoimmune-vasculitis-model">MPO inhibition yields protective efficacy in MPO-ANCA autoimmune vasculitis model</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/714144-hifibio-therapeutics-btla-agonist-antibody-gains-us-ind-clearance">Hifibio Therapeutics’ BTLA agonist antibody gains US IND clearance</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">Endocrine/metabolic</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714695-new-preclinical-data-on-cvi-2742-for-treating-mash">New preclinical data on CVI-2742 for treating MASH</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="bioworld-biome__teaser">The efficacy and capabilities of CVI Pharmaceuticals Inc.'s CVI-2742, a THR-β agonist, were tested in nonhuman primates.</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714519-astrazeneca-exercises-option-for-type-1-diabetes-treg-cell-therapy-program-with-quell">Astrazeneca exercises option for type 1 diabetes Treg cell therapy program with Quell</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/225,520">License</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714434-islet-targeted-gene-therapy-rjva-001-leads-to-durable-weight-loss-in-obese-mice">Islet-targeted gene therapy RJVA-001 leads to durable weight loss in obese mice</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714428-healing-a-health-divide-thats-long-overdue">Healing a health divide (that’s long overdue)</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/109,520">Analysis and data insight</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/714365-new-glp-1r-agonists-disclosed-in-youngene-therapeutics-patent">New GLP-1R agonists disclosed in Youngene Therapeutics patent</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/472,520">Patents</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">More in Endocrine/metabolic</a> </section></div><div class="advertisement topics-section-2__col -two"><a href="https://clarivate.com/contact-us/sales-enquiries/" target="_blank"><img src="https://www.bioworld.com/ext/resources/Ads/2024/bioworld-advertising-audience.jpg" style="width: 300px; height: 250px;"></a></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">Biomarkers</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article clinical--article"><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714570-novel-kdm3b-variant-found-in-atypical-diets-jongmans-case">Novel KDM3B variant found in atypical Diets-Jongmans case </a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">The <em>KDM3B</em> gene encodes the histone lysine demethylase lysine-specific demethylase 3B, which is involved in the regulation of transcription.</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714569-vsx2-variant-linked-to-retinal-detachment-risk">VSX2 variant linked to retinal detachment risk</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">Researchers from the U.K. have analyzed whole-genome sequencing data from 7,276 cases and 236,741 controls in the UK Biobank to perform gene-level and a variant-level exome-wide association study analysis to identify variants related to retinal detachment.</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714463-machine-learning-links-microbiome-composition-to-bacterial-load">Machine learning links microbiome composition to bacterial load</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/111,520">Artificial intelligence</a></div><div class="clinical__teaser">Many studies have linked the presence of specific bacteria to various diseases. But a general overgrowth of gut bacteria can be a symptom of different conditions, including colorectal cancer and inflammatory bowel disease. A study counting gut microbiome proposes that microbial load, rather than...</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714437-iron-levels-in-tears-for-diagnosis-of-emwdr45-em-related-optic-atrophy">Iron levels in tears for diagnosis of <em>WDR45</em>-related optic atrophy</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714390-emgrhl2-em-emgrhl3-em-variants-tied-to-orofacial-clefting"><em>GRHL2</em>, <em>GRHL3</em> variants tied to orofacial clefting</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714357-emcasz1-em-found-as-possible-monogenic-cause-of-primary-aldosteronism"><em>CASZ1</em> found as possible monogenic cause of primary aldosteronism</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/714351-embirc6-em-revealed-as-candidate-gene-for-intellectual-disability"><em>BIRC6</em> revealed as candidate gene for intellectual disability</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">More in Biomarkers</a> </section></div></div></section><section class="topics-section-3__wrapper"><div class="topics-section-3__col"><section class="regulatory "> <h1 class="regulatory__title"><a class="regulatory__title-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-title" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">Gastrointestinal</a></h1><ul class="regulatory__items"> <li class="regulatory__item"> <article class="regulatory__article regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/714684-rtx-001-an-engineered-macrophage-therapy-with-hepatic-regenerative-effects">RTX-001, an engineered macrophage therapy with hepatic regenerative effects </a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="regulatory__teaser">As a consequence of chronic liver disease progression, severe cirrhosis, decompensation and fibrosis culminates in end-stage liver disease (ESLD). There are no treatment options approved for ESLD, but, among others, regenerative therapies with...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/714598-fap-inhibitor-azd-2389-improves-liver-fibrosis-and-mash">FAP inhibitor AZD-2389 improves liver fibrosis and MASH</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="regulatory__teaser">Astrazeneca plc has developed a potent oral fibroblast activation protein (FAP) inhibitor, AZD-2389, that avoids the cleavage of FGF21 and α2-AP. AZD-2389 was tested in cynomolgus monkeys with diet-induced MASH.</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/714577-imhotex-identifies-new-nod2-activators-for-treatment-of-crohns-disease">Imhotex identifies new NOD2 activators for treatment of Crohn’s disease</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="regulatory__teaser">Several recent Imhotex Ltd. patents describe novel analogues of muramyl dipeptide (MDP), desmuramylpeptides (DMPs), acting as nucleotide-binding oligomerization domain-containing protein 2 (NOD2) activators potentially useful for the treatment of...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/714476-evotec-international-divulges-new-lpam-1-antagonists">Evotec International divulges new LPAM-1 antagonists</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="regulatory__teaser">Evotec International GmbH has synthesized integrin α4β7 (LPAM-1) antagonists reported to be useful for the treatment of ulcerative colitis and Crohn’s disease.</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/714470-numab-and-kaken-pharmaceutical-sign-agreement-for-nd-081-for-inflammatory-bowel-disease">Numab and Kaken Pharmaceutical sign agreement for ND-081 for inflammatory bowel disease</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/268,520">Antibody</a></div><div class="regulatory__teaser">Numab Therapeutics AG and Kaken Pharmaceutical Co. Ltd. have signed a new collaboration and option agreement to develop ND-081, a multispecific antibody for the treatment of inflammatory bowel disease.</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/714436-series-b-financing-at-trex-bio-supports-immunology-pipeline-development">Series B financing at Trex Bio supports immunology pipeline development</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/292,520">Financings</a></div><div class="regulatory__teaser">Trex Bio Inc. has closed an oversubscribed $84 million series B financing round to support development of its pipeline of novel therapies that modulate the immune system to restore human tissue immune homeostasis.</div></article> </li> </ul><a class="regulatory__more-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-more-link" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">More in Gastrointestinal</a> </section></div><div class="topics-section-3__col"><h2><a class="topics-section__title-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast"><strong>BioWorld Insider Podcast</strong></a></h2> <p> <strong>One-on-one with medical innovators</strong> </p> <table style="width: 100%;"><tbody><tr><td style="width: 100.0000%;"> <p class="regulatory__teaser"> <img src="/ext/resources/images/podcast-section-image.png" style="display: inline-block; vertical-align: bottom; margin: 2px 15px 5px 0px; text-align: left; float: left; max-width: calc(100% - 5px); width: 221px;" alt="podcast microphone, sound waves on purple background" data-uuid="YTAtMTA2MzQz" align="left">Breakthrough medicines, billion-dollar deals, spectacular clinical successes and crushing failures all play a part in biopharma’s dynamic story. 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Join us each week for a new conversation. </p> </td></tr> <tr><td style="width: 100.0000%;"> <p class="regulatory__teaser"> <br><strong>Recent episodes:</strong> </p> <ul class="regulatory__teaser"> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/53-healing-the-health-divide-for-women" rel=" " target="_self">Healing the health divide for women</a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/52-modifi-gets-creative-on-the-rocky-road-to-a-multibillion-dollar-buyout" rel=" " target="_self">Modifi gets creative on the rocky road to a multibillion-dollar buyout</a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/51-a-quantum-leap-into-the-future-of-drug-development" rel=" noopener noreferrer">A quantum leap into the future of drug development<br></a></li> <li><a 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