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<!doctype html> <html lang="ja"> <head> <title>The Role of B Cells in Autoimmunity: Insights on B Lymphocyt | 50473</title> <meta name="keywords" content="Evan S Vista and Mark Aragones, "/> <meta name="description" content="Systemic lupus erythematosus (SLE) is a heterogenous condition with significant impact on morbidity and mortality among affected individuals, usually young..50473"/> <meta name="citation_publisher" content="ロングダム出版SL" /> <meta name="citation_journal_title" content="音声学と聴覚学ジャーナル"> <meta name="citation_title" content="The Role of B Cells in Autoimmunity: Insights on B Lymphocyte Stimulation (Blys) as a Target for Biologics in Systemic Lupus Erythematosus"> <meta name="citation_author" content="Evan S Vista" /> <meta name="citation_author" content="Mark Aragones" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="6"> <meta name="citation_issue" content="5"> <meta name="citation_abstract" content="Systemic lupus erythematosus (SLE) is a heterogenous condition with significant impact on morbidity and mortality among affected individuals, usually young females during their most productive stage in life. The production of pathogenic autoantibodies has been the classical hallmark for the disease. B cells, the precursor of the antibody producing plasma cells, are believed to play a central role in SLE disease activity. It has long been considered a difficult disease to manage and diagnose due to its wide raging manifestations and severity. This systemic autoimmune condition has attracted many clinicians and researchers for decades in the hope of fully unraveling the disease pathogenesis in order to come up with more effective treatments. Treatment strategies have been broadly directed at dampening the immune response with consequential adverse effects in the long term care of diseased patients. An improved understanding of the role B cells play in lupus pathology has led to the development of belimumab, a monoclonal antibody which became the first successful treatment for SLE introduced after more than half a century. The drug is among the class of targeted biologic therapies now evolving in the field of rheumatology and clinical immunology. It is directed to inhibit the survival of autoreactive B cells that are implicated in SLE disease activity. This review article discusses the stages in B cell ontogeny predisposing SLE development and reports the critical role of B lymphocyte stimulator in the occurrence of SLE disease flares."> <meta name="citation_abstract_html_url" content="https://japanese.longdom.org/abstract/the-role-of-b-cells-in-autoimmunity-insights-on-b-lymphocyte-stimulation-blys-as-a-target-for-biologics-in-systemic-lupu-50473.html"> <meta name="format-detection" content="telephone=no"> <meta http-equiv="Content-Language" content="ja"> <meta name="google-site-verification" content="NomPTP94YozsgvD3NEFpNqUfY88e0TU0L64zNzZTpd0" /> <meta itemprop="name" content="longdom" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link rel="canonical" 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The production of pathogenic autoantibodies has been the classical hallmark for the disease. B cells, the precursor of the antibody producing plasma cells, are believed to play a central role in SLE disease activity. It has long been considered a difficult disease to manage and diagnose due to its wide raging manifestations and severity. This systemic autoimmune condition has attracted many clinicians and researchers for decades in the hope of fully unraveling the disease pathogenesis in order to come up with more effective treatments. Treatment strategies have been broadly directed at dampening the immune response with consequential adverse effects in the long term care of diseased patients. An improved understanding of the role B cells play in lupus pathology has led to the development of belimumab, a monoclonal antibody which became the first successful treatment for SLE introduced after more than half a century. The drug is among the class of targeted biologic therapies now evolving in the field of rheumatology and clinical immunology. It is directed to inhibit the survival of autoreactive B cells that are implicated in SLE disease activity. This review article discusses the stages in B cell ontogeny predisposing SLE development and reports the critical role of B lymphocyte stimulator in the occurrence of SLE disease flares.</p> <div class="alert alert-info text-left"><b>免責事項:</b> この要約は人工知能ツールを使用して翻訳されたものであり、まだレビューまたは検証されていません。</div> <div class="nav social-icons"> <a class="nav-link w-auto">この記事をシェアする</a> <a title="ここをクリック" target="_blank" href="https://www.facebook.com/sharer.php?u=https://japanese.longdom.org/abstract/the-role-of-b-cells-in-autoimmunity-insights-on-b-lymphocyte-stimulation-blys-as-a-target-for-biologics-in-systemic-lupu-50473.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="ここをクリック" target="_blank" href="https://twitter.com/share?url=https://japanese.longdom.org/abstract/the-role-of-b-cells-in-autoimmunity-insights-on-b-lymphocyte-stimulation-blys-as-a-target-for-biologics-in-systemic-lupu-50473.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="ここをクリック" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://japanese.longdom.org/abstract/the-role-of-b-cells-in-autoimmunity-insights-on-b-lymphocyte-stimulation-blys-as-a-target-for-biologics-in-systemic-lupu-50473.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="ここをクリック" target="_blank" href="https://plus.google.com/share?url=https://japanese.longdom.org/abstract/the-role-of-b-cells-in-autoimmunity-insights-on-b-lymphocyte-stimulation-blys-as-a-target-for-biologics-in-systemic-lupu-50473.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">コンテンツリンク</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://japanese.longdom.org/privacy-policy.html" title="ここをクリック">プライバシーポリシー</a></li> <li><a class="" href="https://japanese.longdom.org/terms-conditions.html" title="ここをクリック">利用規約</a></li> <li><a class="" href="https://japanese.longdom.org/authors-reviewers-editors.html" title="ここをクリック">著者、査読者、編集者</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">ロングダムに連絡する</h4> <p><strong>ロングダムグループ SA</strong><br /> ロジェ・ヴァンデンドリッシュ通り、<br /> 18、1150 ブリュッセル、ベルギー<br /> 電話番号: +442038085340<br /> <strong>メール:</strong> <a class="white" href="mailto:info@longdom.org" title="ここをクリック">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">接続</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="ここをクリック" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="ここをクリック" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="ここをクリック" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="ここをクリック" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>著作権 © 2024 <a href="https://japanese.longdom.org/" title="ここをクリック" class="white">ロングダム出版SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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