{"title":"Bone Mineral Density and Trabecular Bone Score in Ukrainian Women with Obesity","authors":"Vladyslav Povoroznyuk, Nataliia Dzerovych, Larysa Martynyuk, Tetiana Kovtun","volume":101,"journal":"International Journal of Medical and Health Sciences","pagesStart":452,"pagesEnd":456,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/10001795","abstract":"Obesity and osteoporosis are the two diseases whose\r\nincreasing prevalence and high impact on the global morbidity and\r\nmortality, during the two recent decades, have gained a status of\r\nmajor health threats worldwide. Obesity purports to affect the bone\r\nmetabolism through complex mechanisms. Debated data on the\r\nconnection between the bone mineral density and fracture prevalence\r\nin the obese patients are widely presented in literature. There is\r\nevidence that the correlation of weight and fracture risk is sitespecific.\r\nThis study is aimed at determining the connection between\r\nthe bone mineral density (BMD) and trabecular bone score (TBS)\r\nparameters in Ukrainian women suffering from obesity. We\r\nexamined 1025 40-89-year-old women, divided them into the groups\r\naccording to their body mass index: Group A included 360 women\r\nwith obesity whose BMI was \u226530 kg\/m2, and Group B \u2013 665 women\r\nwith no obesity and BMI of <30 kg\/m2. The BMD of total body,\r\nlumbar spine at the site L1-L4, femur and forearm were measured by\r\nDXA (Prodigy, GEHC Lunar, Madison, WI, USA). The TBS of L1-\r\nL4 was assessed by means of TBS iNsight\u00ae software installed on our\r\nDXA machine (product of Med-Imaps, Pessac, France). In general,\r\nobese women had a significantly higher BMD of lumbar spine,\r\nfemoral neck, proximal femur, total body and ultradistal forearm\r\n(p<0.001) in comparison with women without obesity. The TBS of\r\nL1-L4 was significantly lower in obese women compared to nonobese\r\nwomen (p<0.001). The BMD of lumbar spine, femoral neck\r\nand total body differed to a significant extent in women of 40-49, 50-\r\n59, 60-69 and 70-79 years (p<0.05). At same time, in women aged\r\n80-89 years the BMD of lumbar spine (p=0.09), femoral neck\r\n(p=0.22) and total body (p=0.06) barely differed. The BMD of\r\nultradistal forearm was significantly higher in women of all age\r\ngroups (p<0.05). The TBS of L1-L4 in all the age groups tended to\r\nreveal the lower parameters in obese women compared with the nonobese;\r\nhowever, those data were not statistically significant. By\r\ncontrast, a significant positive correlation was observed between the\r\nfat mass and the BMD at different sites. The correlation between the\r\nfat mass and TBS of L1-L4 was also significant, although negative.\r\nWomen with vertebral fractures had a significantly lower body\r\nweight, body mass index and total body fat mass in comparison with\r\nwomen without vertebral fractures in their anamnesis. In obese\r\nwomen the frequency of vertebral fractures was 27%, while in\r\nwomen without obesity \u2013 57%. ","references":"[1] S. Bermeo, K. Gunaratnam, G. Duque, \u201cFat and bone interactions,\u201d\r\nCurr. Osteoporos. Rep., vol. 12, no. 2, pp. 235-42, 2014.\r\n[2] J.J. Cao \u201cEffects of obesity on bone metabolism,\u201d J. Orthop. Surg. Res.,\r\nvol. 15, no. 6, p. 30, 2011.\r\n[3] J. Compston \u201cObesity and bone,\u201d Curr. Osteoporos. Rep., vol. 11, no. 1,\r\npp. 30-5, 2013.\r\n[4] A. Faje, A. Klibanski \u201cBody composition and skeletal health: too heavy?\r\nToo thin? ,\u201d Curr. Osteoporos. Rep., vol. 10, no. 3, pp. 208-16, 2012.\r\n[5] M.J. Gon\u00e7alves, A.M. Rodrigues, H. 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