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vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">сакриј</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Навигација </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage" class="mw-list-item"><a href="/wiki/%D0%93%D0%BB%D0%B0%D0%B2%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B0" title="Посетите главну страну [z]" accesskey="z"><span>Главна страна</span></a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%A1%D0%B0%D0%B4%D1%80%D0%B6%D0%B0%D1%98" title="Водичи за прегледање Википедије"><span>Садржај</span></a></li><li id="n-recentchanges" class="mw-list-item"><a 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0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; font-size:25px; line-height:25px\"\u003E\u003Cdiv style=\"padding-left:50px;\"\u003E\u003C/div\u003E\u003C/div\u003E\u003Cdiv style=\"padding-top:2px; color:#444; font-size:1.15em; line-height:1.5;\"\u003E\u003Cdiv style=\"padding-left:8px; padding-right:8px;\"\u003EУчествујте у \u003Cb\u003E\u003Ca href=\"https://sr.wikiquote.org/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D1%86%D0%B8%D1%82%D0%B0%D1%82:%D0%9A%D0%B0%D0%BC%D0%BF%D0%B0%D1%9A%D0%B0_SheSaid_2024\" class=\"extiw\" title=\"q:Викицитат:Кампања SheSaid 2024\"\u003Eкампањи писања цитата значајних жена\u003C/a\u003E\u003C/b\u003E на Викицитату.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\n\u003Cdiv class=\"noticebanner\"\u003E\u003Cdiv class=\"plainlinks\" style=\"background-color: #FBEBEA; border-radius:5px; margin-top:10px; position:relative; border: 1px solid #aaa; font-family: \u0026#39;Helvetica\u0026#39;, \u0026#39;Arial\u0026#39;, sans-serif; line-height: 18px; box-shadow: 0 1px 1px rgba( 0, 0, 0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; font-size:25px; line-height:25px\"\u003E\u003Cdiv style=\"padding-left:50px;\"\u003E\u003C/div\u003E\u003C/div\u003E\u003Cdiv style=\"padding-top:2px; color:#444; font-size:1.15em; line-height:1.5;\"\u003E\u003Cdiv style=\"padding-left:8px; padding-right:8px;\"\u003EПридружите се \u003Cb\u003E\u003Ca href=\"/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%90%D0%BA%D1%86%D0%B8%D1%98%D0%B0_%D0%BF%D1%80%D0%BE%D1%88%D0%B8%D1%80%D0%B8%D0%B2%D0%B0%D1%9A%D0%B0_%D0%BA%D0%BB%D0%B8%D1%86%D0%B0\" title=\"Википедија:Акција проширивања клица\"\u003Eакцији проширивања клица\u003C/a\u003E\u003C/b\u003E.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E";}}());</script></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Сајт"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Садржај" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Садржај</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">сакриј</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Почетак</div> </a> </li> <li id="toc-Zaleđina" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Zaleđina"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Zaleđina</span> </div> </a> <ul id="toc-Zaleđina-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Domeni_su_jedinica_proteinske_strukture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Domeni_su_jedinica_proteinske_strukture"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Domeni su jedinica proteinske strukture</span> </div> </a> <ul id="toc-Domeni_su_jedinica_proteinske_strukture-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Spoljašnje veze</span> </div> </a> <button aria-controls="toc-Spoljašnje_veze-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Садржај одељка Spoljašnje veze</span> </button> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> <li id="toc-Baze_podataka_strukturnih_domena" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Baze_podataka_strukturnih_domena"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Baze podataka strukturnih domena</span> </div> </a> <ul id="toc-Baze_podataka_strukturnih_domena-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Baze_podataka_sekvenci_domena" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Baze_podataka_sekvenci_domena"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Baze podataka sekvenci domena</span> </div> </a> <ul id="toc-Baze_podataka_sekvenci_domena-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Садржај" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Прикажи/сакриј садржај" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Прикажи/сакриј садржај</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Proteinski domen</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Чланак на другим језицима. Доступан на: 30" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-30" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">30 језика</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%86%D8%B7%D8%A7%D9%82_%D8%A8%D8%B1%D9%88%D8%AA%D9%8A%D9%86" title="نطاق بروتين — арапски" lang="ar" hreflang="ar" data-title="نطاق بروتين" data-language-autonym="العربية" data-language-local-name="арапски" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Domain_protein" title="Domain protein — малајски" lang="ms" hreflang="ms" data-title="Domain protein" data-language-autonym="Bahasa Melayu" data-language-local-name="малајски" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Proteinski_domen" title="Proteinski domen — босански" lang="bs" hreflang="bs" data-title="Proteinski domen" data-language-autonym="Bosanski" data-language-local-name="босански" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Domini_proteic" title="Domini proteic — каталонски" lang="ca" hreflang="ca" data-title="Domini proteic" data-language-autonym="Català" data-language-local-name="каталонски" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Dom%C3%A9na_(protein)" title="Doména (protein) — чешки" lang="cs" hreflang="cs" data-title="Doména (protein)" data-language-autonym="Čeština" data-language-local-name="чешки" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Proteindom%C3%A6ne" title="Proteindomæne — дански" lang="da" hreflang="da" data-title="Proteindomæne" data-language-autonym="Dansk" data-language-local-name="дански" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Proteindom%C3%A4ne" title="Proteindomäne — немачки" lang="de" hreflang="de" data-title="Proteindomäne" data-language-autonym="Deutsch" data-language-local-name="немачки" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Domeen_(struktuuribioloogia)" title="Domeen (struktuuribioloogia) — естонски" lang="et" hreflang="et" data-title="Domeen (struktuuribioloogia)" data-language-autonym="Eesti" data-language-local-name="естонски" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Protein_domain" title="Protein domain — енглески" lang="en" hreflang="en" data-title="Protein domain" data-language-autonym="English" data-language-local-name="енглески" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Dominio_proteico" title="Dominio proteico — шпански" lang="es" hreflang="es" data-title="Dominio proteico" data-language-autonym="Español" data-language-local-name="шпански" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AF%D9%88%D9%85%DB%8C%D9%86_%D9%BE%D8%B1%D9%88%D8%AA%D8%A6%DB%8C%D9%86" title="دومین پروتئین — персијски" lang="fa" hreflang="fa" data-title="دومین پروتئین" data-language-autonym="فارسی" data-language-local-name="персијски" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Domaine_prot%C3%A9ique" title="Domaine protéique — француски" lang="fr" hreflang="fr" data-title="Domaine protéique" data-language-autonym="Français" data-language-local-name="француски" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Dominio_proteico" title="Dominio proteico — галицијски" lang="gl" hreflang="gl" data-title="Dominio proteico" data-language-autonym="Galego" data-language-local-name="галицијски" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%9E%D7%AA%D7%97%D7%9D_%D7%91%D7%A7%D7%99%D7%A4%D7%95%D7%9C_%D7%97%D7%9C%D7%91%D7%95%D7%9F" title="מתחם בקיפול חלבון — хебрејски" lang="he" hreflang="he" data-title="מתחם בקיפול חלבון" data-language-autonym="עברית" data-language-local-name="хебрејски" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Proteinska_domena" title="Proteinska domena — хрватски" lang="hr" hreflang="hr" data-title="Proteinska domena" data-language-autonym="Hrvatski" data-language-local-name="хрватски" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Dominio_(biochimica)" title="Dominio (biochimica) — италијански" lang="it" hreflang="it" data-title="Dominio (biochimica)" data-language-autonym="Italiano" data-language-local-name="италијански" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%BF%E3%83%B3%E3%83%91%E3%82%AF%E8%B3%AA%E3%83%89%E3%83%A1%E3%82%A4%E3%83%B3" title="タンパク質ドメイン — јапански" lang="ja" hreflang="ja" data-title="タンパク質ドメイン" data-language-autonym="日本語" data-language-local-name="јапански" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%8B%A8%EB%B0%B1%EC%A7%88_%EB%8F%84%EB%A9%94%EC%9D%B8" title="단백질 도메인 — корејски" lang="ko" hreflang="ko" data-title="단백질 도메인" data-language-autonym="한국어" data-language-local-name="корејски" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Domenas_(biochemija)" title="Domenas (biochemija) — литвански" lang="lt" hreflang="lt" data-title="Domenas (biochemija)" data-language-autonym="Lietuvių" data-language-local-name="литвански" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Feh%C3%A9rjedom%C3%A9n" title="Fehérjedomén — мађарски" lang="hu" hreflang="hu" data-title="Fehérjedomén" data-language-autonym="Magyar" data-language-local-name="мађарски" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%91%D0%B5%D0%BB%D0%BA%D0%BE%D0%B2%D0%B8%D0%BD%D1%81%D0%BA%D0%B8_%D0%B4%D0%BE%D0%BC%D0%B5%D0%BD" title="Белковински домен — македонски" lang="mk" hreflang="mk" data-title="Белковински домен" data-language-autonym="Македонски" data-language-local-name="македонски" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Eiwitdomein" title="Eiwitdomein — холандски" lang="nl" hreflang="nl" data-title="Eiwitdomein" data-language-autonym="Nederlands" data-language-local-name="холандски" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Domena_bia%C5%82ka" title="Domena białka — пољски" lang="pl" hreflang="pl" data-title="Domena białka" data-language-autonym="Polski" data-language-local-name="пољски" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Dom%C3%ADnio_proteico" title="Domínio proteico — португалски" lang="pt" hreflang="pt" data-title="Domínio proteico" data-language-autonym="Português" data-language-local-name="португалски" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%94%D0%BE%D0%BC%D0%B5%D0%BD_%D0%B1%D0%B5%D0%BB%D0%BA%D0%B0" title="Домен белка — руски" lang="ru" hreflang="ru" data-title="Домен белка" data-language-autonym="Русский" data-language-local-name="руски" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Proteinski_domen" title="Proteinski domen — српскохрватски" lang="sh" hreflang="sh" data-title="Proteinski domen" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="српскохрватски" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Proteindom%C3%A4n" title="Proteindomän — шведски" lang="sv" hreflang="sv" data-title="Proteindomän" data-language-autonym="Svenska" data-language-local-name="шведски" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/V%C3%B9ng_protein" title="Vùng protein — вијетнамски" lang="vi" hreflang="vi" data-title="Vùng protein" data-language-autonym="Tiếng Việt" data-language-local-name="вијетнамски" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%91%D1%96%D0%BB%D0%BA%D0%BE%D0%B2%D0%B8%D0%B9_%D0%B4%D0%BE%D0%BC%D0%B5%D0%BD" title="Білковий домен — украјински" lang="uk" hreflang="uk" data-title="Білковий домен" data-language-autonym="Українська" data-language-local-name="украјински" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84%E5%9F%9F" title="蛋白质结构域 — кинески" lang="zh" hreflang="zh" data-title="蛋白质结构域" data-language-autonym="中文" data-language-local-name="кинески" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q898273#sitelinks-wikipedia" title="Уреди међујезичке везе" class="wbc-editpage">Уреди везе</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Именски простори"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Proteinski_domen" title="Прочитајте овај чланак [c]" accesskey="c"><span>Чланак</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%D0%A0%D0%B0%D0%B7%D0%B3%D0%BE%D0%B2%D0%BE%D1%80:Proteinski_domen&action=edit&redlink=1" rel="discussion" class="new" title="Разговарајте о страници (страница не постоји) [t]" accesskey="t"><span>Разговор</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown " > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Промени варијанту језика" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Ћир./lat.</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-varlang-0" class="selected ca-variants-sr mw-list-item"><a href="/sr/Proteinski_domen" lang="sr" hreflang="sr"><span>Ћир./lat.</span></a></li><li id="ca-varlang-1" class="ca-variants-sr-Cyrl mw-list-item"><a href="/sr-ec/Proteinski_domen" lang="sr-Cyrl" hreflang="sr-Cyrl"><span>Ћирилица</span></a></li><li id="ca-varlang-2" class="ca-variants-sr-Latn mw-list-item"><a href="/sr-el/Proteinski_domen" lang="sr-Latn" hreflang="sr-Latn"><span>Latinica</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Погледи"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Proteinski_domen"><span>Читај</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Proteinski_domen&veaction=edit" title="Уредите ову страницу [v]" accesskey="v"><span>Уреди</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Proteinski_domen&action=edit" title="Уредите изворни код ове странице [e]" accesskey="e"><span>Уреди извор</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Proteinski_domen&action=history" title="Историја [h]" accesskey="h"><span>Историја</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Алатке странице"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Алатке" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Алатке</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Алатке</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">сакриј</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Више опција" > <div class="vector-menu-heading"> Радње </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Proteinski_domen"><span>Читај</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Proteinski_domen&veaction=edit" title="Уредите ову страницу [v]" accesskey="v"><span>Уреди</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Proteinski_domen&action=edit" title="Уредите изворни код ове странице [e]" accesskey="e"><span>Уреди извор</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Proteinski_domen&action=history"><span>Историја</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Опште </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A8%D1%82%D0%B0_%D0%B2%D0%BE%D0%B4%D0%B8_%D0%BE%D0%B2%D0%B0%D0%BC%D0%BE/Proteinski_domen" title="Списак свих вики страница које воде овамо [j]" accesskey="j"><span>Шта води овамо</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a 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href="https://commons.wikimedia.org/wiki/Category:Protein_domains" hreflang="en"><span>Викиостава</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q898273" title="Веза ка ставци на спремишту података [g]" accesskey="g"><span>Ставка на Википодацима</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Алатке странице"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Изглед"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Изглед</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">сакриј</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">С Википедије, слободне енциклопедије</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sr" dir="ltr"><figure typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:1pkn.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/67/1pkn.png/250px-1pkn.png" decoding="async" width="250" height="347" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/6/67/1pkn.png 1.5x" data-file-width="364" data-file-height="505" /></a><figcaption>Piruvatna kinaza (<span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1pkn">1pkn</a></span>), protein sa tri domena</figcaption></figure> <p><b>Proteinski domen</b> je deo proteinske sekvence i <a href="/wiki/%D0%A2%D0%B5%D1%80%D1%86%D0%B8%D1%98%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Терцијарна структура протеина">strukture</a> koji može da <a href="/wiki/%D0%95%D0%B2%D0%BE%D0%BB%D1%83%D1%86%D0%B8%D1%98%D0%B0_(%D0%B1%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%98%D0%B0)" title="Еволуција (биологија)">evoluira</a>, funkcioniše, i postoji nezavisno od ostatka proteinskog lanca. Svaki domen formira kompaktnu tri-dimenzionalnu strukturu i često može da bude samostalno stabilan i <a href="/wiki/Proteinsko_sklapanje" class="mw-redirect" title="Proteinsko sklapanje">sklopljen</a>. Mnogi proteini se sastoje od nekoliko strukturnih domena. Jedan domen se može javiti u nizu različitih proteina. <a href="/wiki/%D0%9C%D0%BE%D0%BB%D0%B5%D0%BA%D1%83%D0%BB%D1%81%D0%BA%D0%B0_%D0%B5%D0%B2%D0%BE%D0%BB%D1%83%D1%86%D0%B8%D1%98%D0%B0" class="mw-redirect" title="Молекулска еволуција">Molekulska evolucija</a> koristi domene kao strukturne komponente koje mogu da se kombinuju u različitim aranžmanima da bi se formirali <a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD" title="Протеин">proteini</a> sa različitim funkcijama. Domeni variraju u dužini od oko 25 aminokiselina do 500 aminokiselina. Najkraći domeni kao što su <i>cinkovi prsti</i> su stabilizovani metalnim jonima ili <a href="/wiki/Disulfidna_veza" title="Disulfidna veza">disulfidnim mostovima</a>. Domeni često formiraju funkcionalne jedinice, kao što je kalcijum-vezujući <a href="/wiki/EF-ruka" class="mw-redirect" title="EF-ruka">EF-ruka</a> domen <a href="/wiki/Kalmodulin" title="Kalmodulin">kalmodulina</a>. Pošto su oni samostalno stabilni, domeni mogu da se zamene putem <a href="/wiki/%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%BA%D0%B8_%D0%B8%D0%BD%D0%B6%D0%B5%D1%9A%D0%B5%D1%80%D0%B8%D0%BD%D0%B3" title="Генетички инжењеринг">genetičkog inženjerstva</a> između proteina, čime se formiraju <a href="/w/index.php?title=Hibridni_protein&action=edit&redlink=1" class="new" title="Hibridni protein (страница не постоји)">himerni proteini</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Zaleđina"><span id="Zale.C4.91ina"></span>Zaleđina</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Proteinski_domen&veaction=edit&section=1" title="Уредите одељак „Zaleđina”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Proteinski_domen&action=edit&section=1" title="Уреди извор одељка: Zaleđina"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Koncept <i>domena</i> je prvi predložio Vetlaufer <a href="/wiki/1973" title="1973">1973</a>. na osnovu <a href="/wiki/%D0%9A%D1%80%D0%B8%D1%81%D1%82%D0%B0%D0%BB%D0%BE%D0%B3%D1%80%D0%B0%D1%84%D0%B8%D1%98%D0%B0" title="Кристалографија">kristalografskih</a> studija X-zracima živinskog <a href="/wiki/Lizozim" title="Lizozim">lizozima</a><sup id="cite_ref-Phillips1966_1-0" class="reference"><a href="#cite_note-Phillips1966-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> i <a href="/wiki/Papain" title="Papain">papaina</a><sup id="cite_ref-Drenth1968_2-0" class="reference"><a href="#cite_note-Drenth1968-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> i ograničenih proteolitičkih ispitivanja <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%82%D0%B5%D0%BB%D0%BE" title="Антитело">imunoglobulina</a>.<sup id="cite_ref-Porter1973_3-0" class="reference"><a href="#cite_note-Porter1973-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Edelman1973_4-0" class="reference"><a href="#cite_note-Edelman1973-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> On je definisao domene kao stabilne jedinice <a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0" class="mw-redirect" title="Протеинска структура">proteinske strukture</a> koje mogu da se autonomno sklope. U prošlosti su domeni bili opisani kao jedinice: </p> <ul><li>kompaktne strukture<sup id="cite_ref-Richardson_1981_5-0" class="reference"><a href="#cite_note-Richardson_1981-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li> <li>funkcije i evolucije<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li>sklapanja.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li></ul> <p>Sve ove definicije su validne i često se preklapaju, npr. za kompaktni strukturni domen koji je nađen u nizu različitih proteina je verovatno da se samostalno sklapa unutar svog strukturnog okruženja. Priroda često povezuje nekoliko domena čime se formiraju multi-domeni i multi-funkcionalni proteini sa velikim brojem mogućnosti.<sup id="cite_ref-Chothia1992_8-0" class="reference"><a href="#cite_note-Chothia1992-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> U multi-domenskom proteinu, svaki domen može da izvršava svoju funkciju nezavisno, ili na organizovan način sa svojim susedima. Domeni mogu bilo da služe kao moduli za izgradnju velikih sklopova, kao što su <a href="/wiki/%D0%92%D0%B8%D1%80%D1%83%D1%81" title="Вирус">virusne</a> čestice ili mišićna vlakna, ili do pruže specifična <a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0%D1%82%D0%BE%D1%80" class="mw-redirect" title="Катализатор">katalitička</a> ili vezivna mesta koja su prisutna kod <a href="/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC" title="Ензим">enzima</a> ili regulatornih proteina. </p><p>Primer proteina sa više domena je <a href="/wiki/Piruvatna_kinaza" class="mw-redirect" title="Piruvatna kinaza">piruvatna kinaza</a>, glikolitički enzime koji ima važnu ulogu u regulaciji fluksa od fruktoza-1,6-bifosfata do piruvata. Ovaj protein sadrži sve-β regulatorni domen, α/β-supstrat vezujući domen i α/β-nukleotid vezujući domen, koji su povezani sa nekoliko polipeptidnih spona<sup id="cite_ref-George2002a_9-0" class="reference"><a href="#cite_note-George2002a-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>. Svaki domen u ovom proteinu se javlja u različitim grupama proteinskih familija. </p><p>Centralni α/β-barelni domen, koji vezuje supstrat, je jedan od uobičajenih <a href="/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC" title="Ензим">enzimskih</a> sklopova. On je prisutan kod mnogih različitih enzimskih familija koje katalizuju sasvim nevezane reakcije.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> α/β-barel se obično naziva <a href="/wiki/TIM_barel" title="TIM barel">TIM barelom</a>. Ovo ime potiče od triozno fosfatne izomeraze, u čijoj strukturi je bio prvo uočen.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> On je trenutno klasifikovan u 26 homolognih familija u CATH bazi podataka domena.<sup id="cite_ref-Orengo1997_12-0" class="reference"><a href="#cite_note-Orengo1997-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> TIM barel je formiran od sekvence β-α-β motiva koji su zatvoreni <a href="/wiki/%D0%92%D0%BE%D0%B4%D0%BE%D0%BD%D0%B8%D1%87%D0%BD%D0%B0_%D0%B2%D0%B5%D0%B7%D0%B0" title="Водонична веза">vodoničnim vezivanjem</a> prve i zadnje struke, čime se formira barel sa osam struka. Postoje različita stanovišta o <a href="/wiki/%D0%95%D0%B2%D0%BE%D0%BB%D1%83%D1%86%D0%B8%D1%98%D0%B0_(%D0%B1%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%98%D0%B0)" title="Еволуција (биологија)">evolucionom</a> poreklu ovog domena. Jedna od studija sugestira da se zajednički predački enzim raščlanio u nekoliko familija,<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> dok druga smatra da je stabilna struktura TIM-barela evoluirala putem konvergentne evolucije.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p>TIM barel piruvat kinaze je 'diskontinualan', što znači da je više od jednog polipeptidnog segmenta neophodno da bi se formirao domen. To je verovatno posledica umetanja jednog domena u drugi tokom proteinske evolucije. Bilo je pokazano da je među poznatim strukturama jedna četvrtina strukturnih domena diskontinualna.<sup id="cite_ref-Jones1998_15-0" class="reference"><a href="#cite_note-Jones1998-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Holm1994_16-0" class="reference"><a href="#cite_note-Holm1994-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Umetnuti β-barelni regulatorni domen je 'kontinualan', jer se sastoji od jednog neprekidnog segmenta polipeptida. </p><p><a href="/wiki/%D0%9A%D0%BE%D0%B2%D0%B0%D0%BB%D0%B5%D0%BD%D1%82%D0%BD%D0%B0_%D0%B2%D0%B5%D0%B7%D0%B0" title="Ковалентна веза">Kovalentna veza</a> dva domena ima funkcionalnu i strukturnu prednost jer povećava stabilnost u poređenju sa istim strukturama bez kovalentne veze.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Druge prednosti su zaštita intermedijara unutar inter-domenskog enzimskog otvora, koji bi inače bio nestabilan u vodenom okruženju, i ustaljeni <a href="/wiki/%D0%A1%D1%82%D0%B5%D1%85%D0%B8%D0%BE%D0%BC%D0%B5%D1%82%D1%80%D0%B8%D1%98%D0%B0" title="Стехиометрија">stehiometrijski</a> odnos enzimske aktivnosti koji je neophodan za sekvencijalni niz reakcija.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Domeni_su_jedinica_proteinske_strukture">Domeni su jedinica proteinske strukture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Proteinski_domen&veaction=edit&section=2" title="Уредите одељак „Domeni su jedinica proteinske strukture”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Proteinski_domen&action=edit&section=2" title="Уреди извор одељка: Domeni su jedinica proteinske strukture"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r24414138">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}</style><div role="note" class="hatnote navigation-not-searchable">Glavni članak: <a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0" class="mw-redirect" title="Протеинска структура">Proteinska struktura</a></div> <p><a href="/wiki/%D0%9F%D1%80%D0%B8%D0%BC%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Примарна структура протеина">Primarna struktura</a> <a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD" title="Протеин">proteina</a> (lanac aminokiselina) ultimatno kodira njegovu jedinstvenu sklopljenu 3D konformaciju.<sup id="cite_ref-Anfinsen_1961_19-0" class="reference"><a href="#cite_note-Anfinsen_1961-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> Najvažniji faktor sklapanja proteina u 3D strukturu je distribucija polarnih i nepolarnih bočnih lanaca.<sup id="cite_ref-Cordes_20-0" class="reference"><a href="#cite_note-Cordes-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Sklapanje dovodi do sklanjanja hidrofobnih bočnih lanaca u unutrašnjost molekula da bi se izbegao kontakt sa vodenim okruženjem. Generalno, proteini imaju jezgro formirano od hidrofobnih <a href="/wiki/%D0%90%D0%BC%D0%B8%D0%BD%D0%BE%D0%BA%D0%B8%D1%81%D0%B5%D0%BB%D0%B8%D0%BD%D0%B0" title="Аминокиселина">ostataka</a> okruženo omotačem hidrofilnih ostataka. Pošto su same peptidne veze polarne, one se neutrališu međusobnim vodoničnim vezivanjem u hidrofobnom okruženju. Time se stvaraju regioni polipeptida koji formiraju regularne 3D strukturne motive koji se nazivaju <a href="/wiki/%D0%A1%D0%B5%D0%BA%D1%83%D0%BD%D0%B4%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Секундарна структура протеина">sekundarna struktura</a>. Postoje dva glavna tipa sekundarne strukture: <a href="/wiki/%D0%90%D0%BB%D1%84%D0%B0_%D1%85%D0%B5%D0%BB%D0%B8%D0%BA%D1%81" title="Алфа хеликс">α-heliksi</a> i <a href="/wiki/%D0%91%D0%B5%D1%82%D0%B0_%D1%80%D0%B0%D0%B2%D0%B0%D0%BD" title="Бета раван">β-ravni</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Proteinski_domen&veaction=edit&section=3" title="Уредите одељак „Reference”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Proteinski_domen&action=edit&section=3" title="Уреди извор одељка: Reference"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440201">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-Phillips1966-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Phillips1966_1-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Phillips DC. 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(2001). <a rel="nofollow" class="external text" href="http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11125040">„The COG database: new developments in phylogenetic classification of proteins from complete genomes”</a>. <i>Nucleic Acids Res</i>. <b>29</b> (1): 22—8. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <span class="plainlinks"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC29819">29819</a> <span typeof="mw:File"><span title="Слободан приступ"><img alt="Слободан приступ" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/14px-Lock-green.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/18px-Lock-green.svg.png 2x" data-file-width="512" data-file-height="813" /></span></span></span>. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/11125040">11125040</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2F29.1.22">10.1093/nar/29.1.22</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AProteinski+domen&rft.atitle=The+COG+database%3A+new+developments+in+phylogenetic+classification+of+proteins+from+complete+genomes&rft.au=Tatusov+RL&rft.date=2001&rft.genre=article&rft.issue=1&rft.jtitle=Nucleic+Acids+Res&rft.pages=22-8&rft.volume=29&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC29819&rft_id=http%3A%2F%2Fnar.oxfordjournals.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D11125040&rft_id=info%3Adoi%2F10.1093%2Fnar%2F29.1.22&rft_id=info%3Apmid%2F11125040&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></li> <li><cite class="citation journal">Taylor WR, Orengo CA (1989). „Protein structure alignment”. <i>J Mol Biol</i>. <b>208</b> (1): 1—22. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/2769748">2769748</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0022-2836%2889%2990084-3">10.1016/0022-2836(89)90084-3</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AProteinski+domen&rft.atitle=Protein+structure+alignment&rft.au=Orengo%2C+CA&rft.aufirst=WR&rft.aulast=Taylor&rft.date=1989&rft.genre=article&rft.issue=1&rft.jtitle=J+Mol+Biol&rft.pages=1-22&rft.volume=208&rft_id=info%3Adoi%2F10.1016%2F0022-2836%2889%2990084-3&rft_id=info%3Apmid%2F2769748&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></li> <li><cite class="citation journal">Yang AS, Honig B (1995). „Free energy determinants of secondary structure formation: I. alpha-Helices”. <i>J Mol Biol</i>. <b>252</b> (3): 351—65. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/7563056">7563056</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fjmbi.1995.0502">10.1006/jmbi.1995.0502</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AProteinski+domen&rft.atitle=Free+energy+determinants+of+secondary+structure+formation%3A+I.+alpha-Helices&rft.au=Honig%2C+B&rft.aufirst=AS&rft.aulast=Yang&rft.date=1995&rft.genre=article&rft.issue=3&rft.jtitle=J+Mol+Biol&rft.pages=351-65&rft.volume=252&rft_id=info%3Adoi%2F10.1006%2Fjmbi.1995.0502&rft_id=info%3Apmid%2F7563056&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></li> <li><cite class="citation journal">Yang AS, Honig B (1995). „Free energy determinants of secondary structure formation: II. Antiparallel beta-sheets”. <i>J Mol Biol</i>. <b>252</b> (3): 366—76. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/7563057">7563057</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fjmbi.1995.0503">10.1006/jmbi.1995.0503</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AProteinski+domen&rft.atitle=Free+energy+determinants+of+secondary+structure+formation%3A+II.+Antiparallel+beta-sheets&rft.au=Honig%2C+B&rft.aufirst=AS&rft.aulast=Yang&rft.date=1995&rft.genre=article&rft.issue=3&rft.jtitle=J+Mol+Biol&rft.pages=366-76&rft.volume=252&rft_id=info%3Adoi%2F10.1006%2Fjmbi.1995.0503&rft_id=info%3Apmid%2F7563057&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Proteinski_domen&veaction=edit&section=5" title="Уредите одељак „Spoljašnje veze”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Proteinski_domen&action=edit&section=5" title="Уреди извор одељка: Spoljašnje veze"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r28440192"><div class="refbegin refbegin-columns references-column-count references-column-count-2" style="column-count: 2;"> <ul><li><a rel="nofollow" class="external text" href="http://www.sanger.ac.uk/resources/databases/pfam.html">Proteinske familije (Pfam)</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Baze_podataka_strukturnih_domena">Baze podataka strukturnih domena</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Proteinski_domen&veaction=edit&section=6" title="Уредите одељак „Baze podataka strukturnih domena”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Proteinski_domen&action=edit&section=6" title="Уреди извор одељка: Baze podataka strukturnih domena"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=handbook.section.110">Konzervirani domeni</a></li> <li><a rel="nofollow" class="external text" href="http://www.compbio.dundee.ac.uk/3Dee/">3Dee</a></li> <li><a rel="nofollow" class="external text" href="http://www.cathdb.info/">CATH</a></li> <li><a rel="nofollow" class="external text" href="http://ekhidna.biocenter.helsinki.fi/dali_server/">DALI</a></li> <li><a rel="nofollow" class="external text" href="http://scop.mrc-lmb.cam.ac.uk/scop">SCOP</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140312022143/http://scop.mrc-lmb.cam.ac.uk/scop">Архивирано</a> на сајту <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a> (12. март 2014)</li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20160305090617/http://pawsonlab.mshri.on.ca/index.php?id=30&itemid=63%2F&option=com_content&task=view">Proteinski interakcioni domeni</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Baze_podataka_sekvenci_domena">Baze podataka sekvenci domena</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Proteinski_domen&veaction=edit&section=7" title="Уредите одељак „Baze podataka sekvenci domena”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Proteinski_domen&action=edit&section=7" title="Уреди извор одељка: Baze podataka sekvenci domena"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.ebi.ac.uk/interpro">InterPro</a></li> <li><a rel="nofollow" class="external text" href="http://webarchive.loc.gov/all/20110506030957/http%3A//pfam.sanger.ac.uk/">Pfam</a></li> <li><a rel="nofollow" class="external text" href="http://www.expasy.org/prosite/">PROSITE</a></li> <li><a rel="nofollow" class="external text" href="http://prodom.prabi.fr">ProDom</a><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%9C%D1%80%D1%82%D0%B2%D0%B0_%D0%B2%D0%B5%D0%B7%D0%B0" title="Википедија:Мртва веза"><span title=" Ова веза је мртва и треба је или поправити или уклонити (април 2020)">мртва веза</span></a></i>]</span></sup></li> <li><a rel="nofollow" class="external text" href="http://SMART.embl-heidelberg.de">SMART</a></li> <li><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov:80/Structure/cdd/cdd.shtml">NCBI</a></li> <li><a rel="nofollow" class="external text" href="http://supfam.org/SUPERFAMILY">SUPERFAMILY</a></li></ul> </div> <div style="clear:both;"></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r25469611">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl 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href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A3%D1%80%D0%B5%D0%B4%D0%B8_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Proteinski_domeni-lat" title="Посебно:Уреди страницу/Шаблон:Proteinski domeni-lat"><abbr title="Уредите шаблон" style=";background:#eee8aa;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">у</abbr></a></li></ul></div><div id="Proteinski_domeni" style="font-size:114%;margin:0 4em"><a class="mw-selflink selflink">Proteinski domeni</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/BAR_domen" title="BAR domen">BAR</a> •  <a href="/wiki/Domen_inhibitora_apoptoze" title="Domen inhibitora apoptoze">BIR</a> • <a href="/wiki/BZIP_domen" title="BZIP domen">BZIP</a> •  <a href="/wiki/CARD_domen" title="CARD domen">CARD</a> •  <a href="/wiki/C1_domen" title="C1 domen">C1</a> •  <a href="/wiki/C2_domen" title="C2 domen">C2</a> •  <a href="/wiki/Domen_efektora_smrti" title="Domen efektora smrti">DED</a> •  <a href="/wiki/ENTH_domen" title="ENTH domen">ENTH</a> •  <a href="/wiki/FYVE_domen" title="FYVE domen">FYVE</a> •  <a href="/wiki/Domen_HEAT_ponavljanja" title="Domen HEAT ponavljanja">HEAT</a> • <a href="/wiki/Kringl_domen" title="Kringl domen">Kringl</a> •  <a href="/wiki/LIM_domen" title="LIM domen">LIM</a> •  <a href="/wiki/Ponavljanje_bogato_leucinom" title="Ponavljanje bogato leucinom">LRR</a> • <a href="/wiki/NACHT_domen" title="NACHT domen">NACHT</a> • <a href="/wiki/PAS_domen" title="PAS domen">PAS</a> •  <a href="/wiki/PDZ_domen" title="PDZ domen">PDZ</a> •  <a href="/wiki/Pirinski_domen" title="Pirinski domen">Pirin</a> • <a href="/wiki/Plekstrinski_homologni_domen" title="Plekstrinski homologni domen">PH</a> •  <a href="/wiki/PX_domen" title="PX domen">PX</a> •  <a href="/wiki/SH2_domen" title="SH2 domen">SH2</a> •  <a href="/wiki/SH3_domen" title="SH3 domen">SH3</a> •  <a href="/wiki/SUN_domen" title="SUN domen">SUN</a> •  <a href="/wiki/CRAL-TRIO_domen" title="CRAL-TRIO domen">TRIO</a> •  <a href="/wiki/WD40_ponavljanje" title="WD40 ponavljanje">WD40</a> •  <a href="/wiki/Cinkov_prst" title="Cinkov prst">Cinkov prst</a></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r25469611"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r24365370"></div><div role="navigation" class="navbox" aria-labelledby="Tercijarna_struktura_proteina" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#eee8aa;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r25469611"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r24365379"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-прикажи"><a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Tercijarna_struktura_proteina-lat" title="Шаблон:Tercijarna struktura proteina-lat"><abbr title="Погледајте шаблон" style=";background:#eee8aa;;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">п</abbr></a></li><li class="nv-разговор"><a href="/wiki/%D0%A0%D0%B0%D0%B7%D0%B3%D0%BE%D0%B2%D0%BE%D1%80_%D0%BE_%D1%88%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD%D1%83:Tercijarna_struktura_proteina-lat" title="Разговор о шаблону:Tercijarna struktura proteina-lat"><abbr title="Разговарајте о шаблону" style=";background:#eee8aa;;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">р</abbr></a></li><li class="nv-уреди"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A3%D1%80%D0%B5%D0%B4%D0%B8_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Tercijarna_struktura_proteina-lat" title="Посебно:Уреди страницу/Шаблон:Tercijarna struktura proteina-lat"><abbr title="Уредите шаблон" style=";background:#eee8aa;;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">у</abbr></a></li></ul></div><div id="Tercijarna_struktura_proteina" style="font-size:114%;margin:0 4em"><a href="/wiki/%D0%A2%D0%B5%D1%80%D1%86%D0%B8%D1%98%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Терцијарна структура протеина">Tercijarna struktura proteina</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#eee8aa;">Generalni</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a class="mw-selflink selflink">Strukturni domen</a> <b>·</b>  <a href="/wiki/Proteinsko_sklapanje" class="mw-redirect" title="Proteinsko sklapanje">Proteinsko sklapanje</a> <b>·</b>  <a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0" class="mw-redirect" title="Протеинска структура">Proteinska struktura</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#eee8aa;"><a href="/wiki/Sve_alfa_proteini" title="Sve alfa proteini">Sve-α sklop</a>:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Heliksni_sve%C5%BEanj" title="Heliksni svežanj">Heliksni svežanj</a> <b>·</b>  <a href="/wiki/Globinski_sklop" title="Globinski sklop">Globinski sklop</a> <b>·</b>  <a href="/wiki/Homeodomenski_sklop" title="Homeodomenski sklop">Homeodomenski sklop</a> <b>·</b>  <a href="/wiki/Alfa_solenoid" title="Alfa solenoid">Alfa solenoid</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#eee8aa;">Sve-β sklop:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Imunoglobulinski_domen" title="Imunoglobulinski domen">Imunoglobulinski domen</a> <b>·</b>  <a href="/wiki/Beta_barel" title="Beta barel">Beta barel</a> <b>·</b>  <a href="/wiki/Beta-propeler" title="Beta-propeler">Beta-propeler</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#eee8aa;">α/β sklop:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/TIM_barel" title="TIM barel">TIM barel</a> <b>·</b>  <a href="/wiki/Leucinom-bogato_ponavljanje" class="mw-redirect" title="Leucinom-bogato ponavljanje">Leucinom-bogato ponavljanje</a> <b>·</b>  <a href="/wiki/Flavodoksinski_sklop" title="Flavodoksinski sklop">Flavodoksinski sklop</a> <b>·</b>  <a href="/wiki/Rozmanov_sklop" title="Rozmanov sklop">Rozmanov sklop</a> <b>·</b>  <a href="/wiki/Tioredoksinski_sklop" title="Tioredoksinski sklop">Tioredoksinski sklop</a> <b>·</b>  <a href="/wiki/Trolistni_%C4%8Dvorni_sklop" title="Trolistni čvorni sklop">Trolistni čvorni sklop</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#eee8aa;">α+β sklop:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/DNK_spona" class="mw-redirect" title="DNK spona">DNK spona</a> <b>·</b>  <a href="/wiki/Feredoksinski_sklop" title="Feredoksinski sklop">Feredoksinski sklop</a> <b>·</b>  <a href="/wiki/Ribonukleaza_A" class="mw-redirect" title="Ribonukleaza A">Ribonukleaza A</a> <b>·</b>  <a href="/wiki/SH2_domen" title="SH2 domen">SH2-slični sklop</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#eee8aa;">Neregularni sklopovi:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Konotoksin" title="Konotoksin">Konotoksin</a></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background:#eee8aa;"><div><div style="float:left;"><a href="/wiki/%D0%A1%D0%B5%D0%BA%D1%83%D0%BD%D0%B4%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Секундарна структура протеина">←Sekundarna struktura</a></div><div style="float:right;"><a href="/wiki/%D0%9A%D0%B2%D0%B0%D1%82%D0%B5%D1%80%D0%BD%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Кватернарна структура протеина">Kvaternarna struktura→</a></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r25469611"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r24365370"></div><div role="navigation" class="navbox" aria-labelledby="Proteini" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r25469611"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r24365379"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-prikaži"><a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B5_%D1%82%D0%B5%D0%BC%D0%B5" title="Шаблон:Протеинске теме"><abbr title="Pogledajte šablon" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">p</abbr></a></li><li class="nv-razgovor"><a href="/w/index.php?title=Razgovor_o_%C5%A1ablonu:Proteinske_teme&action=edit&redlink=1" class="new" title="Razgovor o šablonu:Proteinske teme (страница не постоји)"><abbr title="Razgovarajte o šablonu" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A3%D1%80%D0%B5%D0%B4%D0%B8_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83/%C5%A0ablon:Proteinske_teme" title="Посебно:Уреди страницу/Šablon:Proteinske teme"><abbr title="Uredite šablon" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Proteini" style="font-size:114%;margin:0 4em"><a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD" title="Протеин">Proteini</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Procesi</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Proteinska_biosinteza" class="mw-redirect" title="Proteinska biosinteza">Proteinska biosinteza</a> <b>·</b>  <a href="/wiki/Posttranslaciona_modifikacija" title="Posttranslaciona modifikacija">Posttranslaciona modifikacija</a> <b>·</b>  <a href="/wiki/Proteinsko_savijanje" title="Proteinsko savijanje">Proteinsko savijanje</a> <b>·</b>  <a href="/wiki/Proteinsko_sortiranje" title="Proteinsko sortiranje">Proteinsko sortiranje</a> <b>·</b>  <a href="/wiki/Proteom" title="Proteom">Proteom</a> <b>·</b>  <a href="/wiki/Proteinske_metode" title="Proteinske metode">Proteinske metode</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Strukture</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0" class="mw-redirect" title="Протеинска структура">Proteinska struktura</a> <b>·</b>  <a class="mw-selflink selflink">Proteinski strukturni domeni</a> <b>·</b>  <a href="/wiki/Proteazom" title="Proteazom">Proteazom</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Tipovi</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Spisak_tipova_proteina" title="Spisak tipova proteina">Spisak tipova proteina</a> <b>·</b>  <a href="/wiki/Membranski_protein" title="Membranski protein">Membranski protein</a> <b>·</b>  <a href="/wiki/Globularni_protein" title="Globularni protein">Globularni protein</a> (<a href="/wiki/Globulin" title="Globulin">Globulin</a>, <a href="/wiki/%D0%90%D0%BB%D0%B1%D1%83%D0%BC%D0%B8%D0%BD" title="Албумин">Albumin</a>) <b>·</b>  <a href="/wiki/Skleroprotein" class="mw-redirect" title="Skleroprotein">Fibrozni protein</a></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r25469611"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r24365370"></div><div role="navigation" class="navbox" aria-labelledby="Biomolekularne_strukture" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:lightblue;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r25469611"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r24365379"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-prikaži"><a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:%D0%91%D0%B8%D0%BE%D0%BC%D0%BE%D0%BB%D0%B5%D0%BA%D1%83%D0%BB%D0%B0%D1%80%D0%BD%D0%B5_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B5" title="Шаблон:Биомолекуларне структуре"><abbr title="Pogledajte šablon" style=";background:lightblue;;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">p</abbr></a></li><li class="nv-razgovor"><a href="/w/index.php?title=Razgovor_o_%C5%A1ablonu:Biomolekularne_strukture&action=edit&redlink=1" class="new" title="Razgovor o šablonu:Biomolekularne strukture (страница не постоји)"><abbr title="Razgovarajte o šablonu" style=";background:lightblue;;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A3%D1%80%D0%B5%D0%B4%D0%B8_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83/%C5%A0ablon:Biomolekularne_strukture" title="Посебно:Уреди страницу/Šablon:Biomolekularne strukture"><abbr title="Uredite šablon" style=";background:lightblue;;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Biomolekularne_strukture" style="font-size:114%;margin:0 4em"><a href="/wiki/Biomolekul" title="Biomolekul">Biomolekularne strukture</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:lightblue;1.2em"><a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0" class="mw-redirect" title="Протеинска структура">Proteinska struktura</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0;background:white; line-height:1.5em;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/%D0%9F%D1%80%D0%B8%D0%BC%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Примарна структура протеина">Primarna</a></li> <li><a href="/wiki/%D0%A1%D0%B5%D0%BA%D1%83%D0%BD%D0%B4%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Секундарна структура протеина">Sekundarna</a></li> <li><a href="/wiki/%D0%A2%D0%B5%D1%80%D1%86%D0%B8%D1%98%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Терцијарна структура протеина">Tercijarna</a></li> <li><a href="/wiki/%D0%9A%D0%B2%D0%B0%D1%82%D0%B5%D1%80%D0%BD%D0%B0%D1%80%D0%BD%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Кватернарна структура протеина">Kvaternarna</a></li> <li><a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0" class="mw-redirect" title="Протеинска структура">Određivanje</a></li> <li><a href="/wiki/%D0%9F%D1%80%D0%B5%D0%B4%D0%B2%D0%B8%D1%92%D0%B0%D1%9A%D0%B5_%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B5_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Предвиђање структуре протеина">Predviđanje</a></li> <li><a href="/wiki/Dizajn_proteina" title="Dizajn proteina">Dizajn</a></li> <li><a href="/wiki/Proteinsko_savijanje" title="Proteinsko savijanje">Termodinamika</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:lightblue;1.2em"><a href="/wiki/Struktura_nukleinske_kiseline" title="Struktura nukleinske kiseline">Struktura nukleinske kiseline</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0;background:white; line-height:1.5em;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sekvenca_nukleinskih_kiselina" title="Sekvenca nukleinskih kiselina">Primarna</a></li> <li><a href="/wiki/Sekundarna_struktura_nukleinskih_kiselina" title="Sekundarna struktura nukleinskih kiselina">Sekundarna</a></li> <li><a href="/wiki/Tercijarna_struktura_nukleinskih_kiselina" title="Tercijarna struktura nukleinskih kiselina">Tercijarna</a></li> <li><a href="/wiki/Kvaternarna_struktura_nukleinskih_kiselina" title="Kvaternarna struktura nukleinskih kiselina">Kvaternarna</a></li> <li><a href="/wiki/Odre%C4%91ivanje_strukture_nukleinskih_kiselina" title="Određivanje strukture nukleinskih kiselina">Određivanje</a></li> <li><a href="/wiki/Predvi%C4%91anje_strukture_nukleinskih_kiselina" title="Predviđanje strukture nukleinskih kiselina">Predviđanje</a></li> <li><a href="/wiki/Dizajn_nukleinskih_kiselina" title="Dizajn nukleinskih kiselina">Dizajn</a></li> <li><a href="/wiki/%D0%A5%D0%B8%D0%B1%D1%80%D0%B8%D0%B4%D0%B8%D0%B7%D0%B0%D1%86%D0%B8%D1%98%D0%B0_%D0%94%D0%9D%D0%9A" title="Хибридизација ДНК">Termodinamika</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:lightblue;1.2em">Vidi isto</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0;background:white; line-height:1.5em;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD" title="Протеин">Protein</a></li> <li><a class="mw-selflink selflink">Proteinski domen</a></li> <li><a href="/wiki/Proteinsko_in%C5%BEenjerstvo" title="Proteinsko inženjerstvo">Proteinsko inženjerstvo</a></li> <li><a href="/wiki/%D0%9D%D1%83%D0%BA%D0%BB%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B5_%D0%BA%D0%B8%D1%81%D0%B5%D0%BB%D0%B8%D0%BD%D0%B5" title="Нуклеинске киселине">Nukleinske kiseline</a></li> <li><a href="/wiki/%D0%94%D0%B5%D0%B7%D0%BE%D0%BA%D1%81%D0%B8%D1%80%D0%B8%D0%B1%D0%BE%D0%BD%D1%83%D0%BA%D0%BB%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D0%BA%D0%B8%D1%81%D0%B5%D0%BB%D0%B8%D0%BD%D0%B0" title="Дезоксирибонуклеинска киселина">DNK</a></li> <li><a href="/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D0%BD%D1%83%D0%BA%D0%BB%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B0_%D0%BA%D0%B8%D1%81%D0%B5%D0%BB%D0%B8%D0%BD%D0%B0" title="Рибонуклеинска киселина">RNK</a></li> <li><a href="/wiki/Dvostruki_heliks_nukleinske_kiseline" title="Dvostruki heliks nukleinske kiseline">Dvostruki heliks nukleinske kiseline</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Преузето из „<a dir="ltr" href="https://sr.wikipedia.org/w/index.php?title=Proteinski_domen&oldid=27839696">https://sr.wikipedia.org/w/index.php?title=Proteinski_domen&oldid=27839696</a>”</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B5" title="Посебно:Категорије">Категорије</a>: <ul><li><a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B0:%D0%A1%D1%82%D1%80%D1%83%D0%BA%D1%82%D1%83%D1%80%D0%B0_%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D0%B0" title="Категорија:Структура протеина">Структура протеина</a></li><li><a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B0:%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%81%D0%BA%D0%B8_%D0%B4%D0%BE%D0%BC%D0%B5%D0%BD%D0%B8" title="Категорија:Протеински домени">Протеински домени</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Сакривене категорије: <ul><li><a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B0:%D0%A1%D0%B2%D0%B8_%D1%87%D0%BB%D0%B0%D0%BD%D1%86%D0%B8_%D1%81%D0%B0_%D0%BC%D1%80%D1%82%D0%B2%D0%B8%D0%BC_%D0%B2%D0%B5%D0%B7%D0%B0%D0%BC%D0%B0" title="Категорија:Сви чланци са мртвим везама">Сви чланци са мртвим везама</a></li><li><a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B0:%D0%A7%D0%BB%D0%B0%D0%BD%D1%86%D0%B8_%D1%81%D0%B0_%D0%BC%D1%80%D1%82%D0%B2%D0%B8%D0%BC_%D0%B2%D0%B5%D0%B7%D0%B0%D0%BC%D0%B0_%D0%BE%D0%B4_09._2018." title="Категорија:Чланци са мртвим везама од 09. 2018.">Чланци са мртвим везама од 09. 2018.</a></li><li><a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B0:%D0%A7%D0%BB%D0%B0%D0%BD%D1%86%D0%B8_%D1%81%D0%B0_%D1%82%D1%80%D0%B0%D1%98%D0%BD%D0%BE_%D0%BC%D1%80%D1%82%D0%B2%D0%B8%D0%BC_%D1%81%D0%BF%D0%BE%D1%99%D0%B0%D1%88%D1%9A%D0%B8%D0%BC_%D0%B2%D0%B5%D0%B7%D0%B0%D0%BC%D0%B0" title="Категорија:Чланци са трајно мртвим спољашњим везама">Чланци са трајно мртвим спољашњим везама</a></li><li><a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B0:%D0%A7%D0%BB%D0%B0%D0%BD%D1%86%D0%B8_%D1%81%D0%B0_%D1%88%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD%D0%B8%D0%BC%D0%B0_%D1%85%D1%83%D1%82%D0%BD%D0%BE%D1%82%D0%B0_%D0%BA%D0%BE%D1%98%D0%B8_%D1%86%D0%B8%D1%99%D0%B0%D1%98%D1%83_%D0%BD%D0%B5%D0%BF%D0%BE%D1%81%D1%82%D0%BE%D1%98%D0%B5%D1%9B%D1%83_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83" title="Категорија:Чланци са шаблонима хутнота који циљају непостојећу страницу">Чланци са шаблонима хутнота који циљају непостојећу страницу</a></li><li><a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B0:%D0%A7%D0%BB%D0%B0%D0%BD%D1%86%D0%B8_%D1%81%D0%B0_%D0%BC%D1%80%D1%82%D0%B2%D0%B8%D0%BC_%D0%B2%D0%B5%D0%B7%D0%B0%D0%BC%D0%B0_%D0%BE%D0%B4_04._2020." title="Категорија:Чланци са мртвим везама од 04. 2020.">Чланци са мртвим везама од 04. 2020.</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Датум и време последње измене странице: 6. јун 2024. у 02:10.</li> <li id="footer-info-copyright">Текст је доступан под лиценцом <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/">Creative Commons Ауторство—Делити под истим условима</a>; могући су и додатни услови. 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