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<!doctype html> <html lang="de"> <head> <title>Smad7 Sustains Inflammation in the Gut: From Bench to Bedsid | 49498</title> <meta name="keywords" content="Irene Marafini, Silvia Sedda, Davide Di Fusco, Michele M Figliuzzi, Francesco Pallone and Giovanni Monteleone , "/> <meta name="description" content="In Crohn’s disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD) in human beings, the pathological proces..49498"/> <meta name="citation_publisher" content="Longdom Publishing SL" /> <meta name="citation_journal_title" content="Zeitschrift für klinische und zelluläre Immunologie"> <meta name="citation_title" content="Smad7 Sustains Inflammation in the Gut: From Bench to Bedside"> <meta name="citation_author" content="Irene Marafini" /> <meta name="citation_author" content="Silvia Sedda" /> <meta name="citation_author" content="Davide Di Fusco" /> <meta name="citation_author" content="Michele M Figliuzzi" /> <meta name="citation_author" content="Francesco Pallone" /> <meta name="citation_author" content="Giovanni Monteleone" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="5"> <meta name="citation_issue" content="4"> <meta name="citation_abstract" content="In Crohn’s disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD) in human beings, the pathological process is driven by an excessive immune response that is directed against components of the luminal flora and inappropriately controlled by immunesuppressive mechanisms. One such a mechanism involves TGF-β1, a pleiotropic cytokine that targets both immune and non-immune cells in the gut. TGF- β1 is highly expressed in inflamed mucosa of IBD patients but paradoxically it is unable to activate Smad-associated intracellular signalling and suppress inflammatory cytokine responses. This is because IBD-related inflammation is marked by elevated levels of Smad7, an inhibitor of TGF-β1 signalling. Consistently, knockdown of Smad7 with a specific antisense oligonucleotide restores TGF-β1 function, inhibits inflammatory cytokine production, and ameliorates colitis in mice. In this article we review the available data supporting the pathogenic role of Smad7 in gut as well as the results of a recent phase 1 trial assessing the safety and tolerability of a Smad7 antisense oligonucleotide in CD patients. 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title="Hier klicken">Wirtschaft & Management</a><br> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9"> <h2 class="heading-1">Abstrakt</h2> <h3 class="">Smad7 Sustains Inflammation in the Gut: From Bench to Bedside</h3> <p> <i class="fas fa-user"></i> Irene Marafini, Silvia Sedda, Davide Di Fusco, Michele M Figliuzzi, Francesco Pallone and Giovanni Monteleone </p> <p>In Crohn’s disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD) in human beings, the pathological process is driven by an excessive immune response that is directed against components of the luminal flora and inappropriately controlled by immunesuppressive mechanisms. One such a mechanism involves TGF-β1, a pleiotropic cytokine that targets both immune and non-immune cells in the gut. TGF- β1 is highly expressed in inflamed mucosa of IBD patients but paradoxically it is unable to activate Smad-associated intracellular signalling and suppress inflammatory cytokine responses. This is because IBD-related inflammation is marked by elevated levels of Smad7, an inhibitor of TGF-β1 signalling. Consistently, knockdown of Smad7 with a specific antisense oligonucleotide restores TGF-β1 function, inhibits inflammatory cytokine production, and ameliorates colitis in mice. In this article we review the available data supporting the pathogenic role of Smad7 in gut as well as the results of a recent phase 1 trial assessing the safety and tolerability of a Smad7 antisense oligonucleotide in CD patients.</p> <div class="alert alert-info text-left"><b>Haftungsausschluss:</b> Diese Zusammenfassung wurde mithilfe von Tools der k眉nstlichen Intelligenz 眉bersetzt und wurde noch nicht 眉berpr眉ft oder verifiziert.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Teile diesen Artikel</a> <a title="Hier klicken" target="_blank" href="https://www.facebook.com/sharer.php?u=https://german.longdom.org/abstract/smad7-sustains-inflammation-in-the-gut-from-bench-to-bedside-49498.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Hier klicken" target="_blank" href="https://twitter.com/share?url=https://german.longdom.org/abstract/smad7-sustains-inflammation-in-the-gut-from-bench-to-bedside-49498.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Hier klicken" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://german.longdom.org/abstract/smad7-sustains-inflammation-in-the-gut-from-bench-to-bedside-49498.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Hier klicken" target="_blank" href="https://plus.google.com/share?url=https://german.longdom.org/abstract/smad7-sustains-inflammation-in-the-gut-from-bench-to-bedside-49498.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Inhaltslinks</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://german.longdom.org/privacy-policy.html" title="Hier klicken">Datenschutzrichtlinie</a></li> <li><a class="" href="https://german.longdom.org/terms-conditions.html" title="Hier klicken">Allgemeine Gesch盲ftsbedingungen</a></li> <li><a class="" href="https://german.longdom.org/authors-reviewers-editors.html" title="Hier klicken">Autoren, Gutachter & Herausgeber</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Kontaktieren Sie Longdom</h4> <p><strong>Longdom Group SA</strong><br /> Avenue Roger Vandendriessche,<br /> 18, 1150 Br眉ssel, Belgien<br /> Telefon: +442038085340<br /> <strong>E-Mail:</strong> <a class="white" href="mailto:info@longdom.org" title="Hier klicken">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Verbinden</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Hier klicken" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Hier klicken" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="Hier klicken" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="Hier klicken" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Urheberrechte 漏 © 2024 <a href="https://german.longdom.org/" title="Hier klicken" class="white">Longdom Publishing SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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