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Furthermore, this study investigated the possible mechanisms of a standardized extract" /> <title>(PDF) NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway | Alaaeldin A Hamza - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732390936000); window.Aedu.timeDifference = new Date().getTime() - 1732390936000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Ginger has been proposed as quite a promising candidate for cancer prevention. The purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this study investigated the possible mechanisms of a standardized extract drawn from the rhizomes of ginger against diethylnitrosamine (DEN)-induced liver cancer in Wistar rats. The chemo-preventive effects of ginger at doses of 75 mg/kg, 150 mg/kg and 300 mg/kg per day were determined using a liver cancer model which was induced by DEN (Ali et al., 2008) and 2-acetylaminofluor-ene (2-AAF) in rats. Ginger attenuated carcinogenic changes after 22 weeks of cancer induction by decreasing the quantity and occurrences of hepatic dyschromatic nodules and positive focal areas as well as decreasing the amount of placental glutathione S-transferase (GST) in the livers of DEN/2-AAF-treated rats. Moreover, in rats, ginger counteracts DEN-influenced oxidative stress and decreases myeloperoxidase, malondialdehyde and protein carbonyl concentrations in the liver. This was determined by observing the restoration of superoxide dis-mutase, catalase, GST and glutathione. Immunohistochemical bleaching in rat livers showed that ginger prevented the increase in cell-positive numbers for Ki-67, cyclooxygenase-2 and nuclear factor kappa B p65. Ginger also inhibited the number of positive cells in DEN/2-AAF-treated rats for TUNEL, M30 and caspase-3 liver tissues. This research shows that ginger has an important chemo-preventative impact on liver cancer by inhibiting the growth of cells and inducing apoptosis. By reducing oxidative and inflammatory damage, ginger protects rat liver against cancer.","author":[{"@context":"https://schema.org","@type":"Person","name":"Alaaeldin A Hamza"}],"contributor":[],"dateCreated":"2021-04-10","dateModified":"2021-04-10","datePublished":"2021-01-01","headline":"NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway","inLanguage":"en","keywords":["Liver Cancer Treatment","Ginger Powder"],"locationCreated":null,"publication":"Elsevier Masson 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The purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this study investigated the possible mechanisms of a standardized extract drawn from the rhizomes of ginger against diethylnitrosamine (DEN)-induced liver cancer in Wistar rats. The chemo-preventive effects of ginger at doses of 75 mg/kg, 150 mg/kg and 300 mg/kg per day were determined using a liver cancer model which was induced by DEN (Ali et al., 2008) and 2-acetylaminofluor-ene (2-AAF) in rats. Ginger attenuated carcinogenic changes after 22 weeks of cancer induction by decreasing the quantity and occurrences of hepatic dyschromatic nodules and positive focal areas as well as decreasing the amount of placental glutathione S-transferase (GST) in the livers of DEN/2-AAF-treated rats. Moreover, in rats, ginger counteracts DEN-influenced oxidative stress and decreases myeloperoxidase, malondialdehyde and protein carbonyl concentrations in the liver. This was determined by observing the restoration of superoxide dis-mutase, catalase, GST and glutathione. Immunohistochemical bleaching in rat livers showed that ginger prevented the increase in cell-positive numbers for Ki-67, cyclooxygenase-2 and nuclear factor kappa B p65. Ginger also inhibited the number of positive cells in DEN/2-AAF-treated rats for TUNEL, M30 and caspase-3 liver tissues. This research shows that ginger has an important chemo-preventative impact on liver cancer by inhibiting the growth of cells and inducing apoptosis. By reducing oxidative and inflammatory damage, ginger protects rat liver against cancer.","publication_date":"2021,,","publication_name":"Elsevier Masson SAS"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway","broadcastable":false,"draft":false,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [29829624]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":66228604,"attachmentType":"pdf"}"><img alt="First page of “NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/66228604/mini_magick20210410-1637-u5af.png?1618074072" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="29829624" href="https://mohp.academia.edu/AlaaeldinHamza"><img alt="Profile image of Alaaeldin A Hamza" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/29829624/8585524/138391921/s65_alaaeldin.hamza.jpg" />Alaaeldin A Hamza</a></div><p class="ds-work-card--detail ds2-5-body-sm">2021, Elsevier Masson SAS</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Ginger has been proposed as quite a promising candidate for cancer prevention. The purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this study investigated the possible mechanisms of a standardized extract drawn from the rhizomes of ginger against diethylnitrosamine (DEN)-induced liver cancer in Wistar rats. The chemo-preventive effects of ginger at doses of 75 mg/kg, 150 mg/kg and 300 mg/kg per day were determined using a liver cancer model which was induced by DEN (Ali et al., 2008) and 2-acetylaminofluor-ene (2-AAF) in rats. Ginger attenuated carcinogenic changes after 22 weeks of cancer induction by decreasing the quantity and occurrences of hepatic dyschromatic nodules and positive focal areas as well as decreasing the amount of placental glutathione S-transferase (GST) in the livers of DEN/2-AAF-treated rats. Moreover, in rats, ginger counteracts DEN-influenced oxidative stress and decreases myeloperoxidase, malondialdehyde and protein carbonyl concentrations in the liver. This was determined by observing the restoration of superoxide dis-mutase, catalase, GST and glutathione. Immunohistochemical bleaching in rat livers showed that ginger prevented the increase in cell-positive numbers for Ki-67, cyclooxygenase-2 and nuclear factor kappa B p65. Ginger also inhibited the number of positive cells in DEN/2-AAF-treated rats for TUNEL, M30 and caspase-3 liver tissues. This research shows that ginger has an important chemo-preventative impact on liver cancer by inhibiting the growth of cells and inducing apoptosis. By reducing oxidative and inflammatory damage, ginger protects rat liver against cancer.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":66228604,"attachmentType":"pdf","workUrl":"https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":66228604,"attachmentType":"pdf","workUrl":"https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="66228604" data-landing_url="https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="115253648" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/115253648/Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway">Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29829624" href="https://mohp.academia.edu/AlaaeldinHamza">Alaaeldin A Hamza</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biomedicine &amp; Pharmacotherapy, 2021</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway","attachmentId":111714966,"attachmentType":"pdf","work_url":"https://www.academia.edu/115253648/Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/115253648/Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="61705259" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61705259/Chemopreventive_efficacy_of_ginger_i_Zingiber_officinale_i_in_ethionine_induced_rat_hepatocarcinogenesis">Chemopreventive efficacy of ginger (<i>Zingiber officinale</i>) in ethionine induced rat hepatocarcinogenesis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5933160" href="https://independent.academia.edu/YasminMohdYusof">Yasmin Mohd Yusof</a></div><p class="ds-related-work--metadata ds2-5-body-xs">African Journal of Traditional, Complementary and Alternative Medicines, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Chemopreventive efficacy of ginger (\u003ci\u003eZingiber officinale\u003c/i\u003e) in ethionine induced rat hepatocarcinogenesis","attachmentId":74675729,"attachmentType":"pdf","work_url":"https://www.academia.edu/61705259/Chemopreventive_efficacy_of_ginger_i_Zingiber_officinale_i_in_ethionine_induced_rat_hepatocarcinogenesis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/61705259/Chemopreventive_efficacy_of_ginger_i_Zingiber_officinale_i_in_ethionine_induced_rat_hepatocarcinogenesis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="4673108" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4673108/Ginger_extract_Zingiber_officinale_has_anti_cancer_and_anti_inflammatory_effects_on_ethionine_induced_hepatoma_rats">Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5933160" href="https://independent.academia.edu/YasminMohdYusof">Yasmin Mohd Yusof</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinics, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">OBJECTIVE: To evaluate the effect of ginger extract on the expression of NFκB and TNF-α in liver cancer-induced rats. METHODS: Male Wistar rats were randomly divided into 5 groups based on diet: i) control (given normal rat chow), ii) olive oil, iii) ginger extract (100mg/kg body weight), iv) choline-deficient diet + 0.1% ethionine to induce liver cancer and v) choline-deficient diet + ginger extract (100mg/kg body weight). Tissue samples obtained at eight weeks were fixed with formalin and embedded in paraffin wax, followed by immunohistochemistry staining for NFκB and TNF-α. RESULTS: The expression of NFκB was detected in the choline-deficient diet group, with 88.3 ± 1.83% of samples showing positive staining, while in the choline-deficient diet supplemented with ginger group, the expression of NFκB was significantly reduced, to 32.35 ± 1.34% (p<0.05). In the choline-deficient diet group, 83.3 ± 4.52% of samples showed positive staining of TNF-α, which was significantly reduced to 7.94 ± 1.32% (p<0.05) when treated with ginger. There was a significant correlation demonstrated between NFκB and TNF-α in the choline-deficient diet group but not in the choline-deficient diet treated with ginger extract group. CONCLUSION: In conclusion, ginger extract significantly reduced the elevated expression of NFκB and TNF-α in rats with liver cancer. Ginger may act as an anti-cancer and anti-inflammatory agent by inactivating NFκB through the suppression of the pro-inflammatory TNF-α.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats","attachmentId":49703501,"attachmentType":"pdf","work_url":"https://www.academia.edu/4673108/Ginger_extract_Zingiber_officinale_has_anti_cancer_and_anti_inflammatory_effects_on_ethionine_induced_hepatoma_rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4673108/Ginger_extract_Zingiber_officinale_has_anti_cancer_and_anti_inflammatory_effects_on_ethionine_induced_hepatoma_rats"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="61230742" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61230742/Gingers_and_Their_Purified_Components_as_Cancer_Chemopreventative_Agents">Gingers and Their Purified Components as Cancer Chemopreventative Agents</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="112414261" href="https://independent.academia.edu/JohnLechner1">John Lechner</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecules</p><p class="ds-related-work--abstract ds2-5-body-sm">Chemoprevention by ingested substituents is the process through which nutraceuticals and/or their bioactive components antagonize carcinogenesis. Carcinogenesis is the course of action whereby a normal cell is transformed into a neoplastic cell. This latter action involves several steps, starting with initiation and followed by promotion and progression. Driving these stages is continued oxidative stress and inflammation, which in turn, causes a myriad of aberrant gene expressions and mutations within the transforming cell population and abnormal gene expressions by the cells within the surrounding lesion. Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs primarily via normalizing these inappropriate gene activities. Various foods/agents have been shown to affect different gene expressions. In this review, we discuss how the chemoprevention activities of gingers antagonize cancer development.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Gingers and Their Purified Components as Cancer Chemopreventative Agents","attachmentId":74333627,"attachmentType":"pdf","work_url":"https://www.academia.edu/61230742/Gingers_and_Their_Purified_Components_as_Cancer_Chemopreventative_Agents","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/61230742/Gingers_and_Their_Purified_Components_as_Cancer_Chemopreventative_Agents"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="57573668" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57573668/The_Carcinogenic_Agent_Diethylnitrosamine_Induces_Early_Oxidative_Stress_Inflammation_and_Proliferation_in_Rat_Liver_Stomach_and_Colon_Protective_Effect_of_Ginger_Extract">The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50675110" href="https://independent.academia.edu/BassantIbrahim">Bassant M M Ibrahim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Pacific Journal of Cancer Prevention</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract","attachmentId":72409708,"attachmentType":"pdf","work_url":"https://www.academia.edu/57573668/The_Carcinogenic_Agent_Diethylnitrosamine_Induces_Early_Oxidative_Stress_Inflammation_and_Proliferation_in_Rat_Liver_Stomach_and_Colon_Protective_Effect_of_Ginger_Extract","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/57573668/The_Carcinogenic_Agent_Diethylnitrosamine_Induces_Early_Oxidative_Stress_Inflammation_and_Proliferation_in_Rat_Liver_Stomach_and_Colon_Protective_Effect_of_Ginger_Extract"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="28244364" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28244364/Cancer_preventive_properties_of_ginger_A_brief_review_q">Cancer preventive properties of ginger: A brief review q</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="52935083" href="https://independent.academia.edu/MohamedHassan454">Mohamed Hassan</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Ginger, the rhizome of Zingiber officinalis, one of the most widely used species of the ginger family, is a common condiment for various foods and beverages. Ginger has a long history of medicinal use dating back 2500 years. Ginger has been traditionally used from time immemorial for varied human ailments in different parts of the globe, to aid digestion and treat stomach upset, diarrhoea, and nausea. Some pungent constituents present in ginger and other zingiberaceous plants have potent antioxidant and anti-inflammatory activities, and some of them exhibit cancer preventive activity in experimental carcinogenesis. The anticancer properties of ginger are attributed to the presence of certain pungent vallinoids, viz. [6]-gingerol and [6]-paradol, as well as some other constituents like shogaols, zingerone etc. A number of mechanisms that may be involved in the chemopreventive effects of ginger and its components have been reported from the laboratory studies in a wide range of experimental models.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cancer preventive properties of ginger: A brief review q","attachmentId":48563898,"attachmentType":"pdf","work_url":"https://www.academia.edu/28244364/Cancer_preventive_properties_of_ginger_A_brief_review_q","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/28244364/Cancer_preventive_properties_of_ginger_A_brief_review_q"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="88844995" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/88844995/6_Gingerol_a_Major_Ingredient_of_Ginger_Attenuates_Diethylnitrosamine_Induced_Liver_Injury_in_Rats_through_the_Modulation_of_Oxidative_Stress_and_Anti_Inflammatory_Activity">6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="586191" href="https://amu-in.academia.edu/shehwazanwar">shehwaz anwar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mediators of Inflammation, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Diethylnitrosamine (DEN) is a well-known hepatocarcinogen, and its oral administration causes severe liver damage including cancer. DEN induces the pathogenesis of the liver through reactive oxygen species mediated inflammation and modulation of various biological activities. 6-Gingerol, a major component of ginger, is reported to prevent liver diseases by reducing the oxidative stress and proinflammatory mediators. The present study investigated the hepatoprotective effects of 6-gingerol through the measurement of oxidative stress, anti-inflammatory markers, liver function enzyme parameter, and histopathological analysis. The rats were randomly divided into four groups as the control, DEN treated (50 mg/kg b.w.), DEN+6-gingerol (each 50 mg/kg b.w.), and 6-gingerol only. To evaluate the hepatoprotective effects, liver function enzymes (ALT, AST, and ALP), oxidative stress markers (SOD, GSH, GST, and TAC), lipid peroxidation, inflammatory markers (CRP, TNF-α, IL-6, and ICAM1), haemat...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity","attachmentId":92753007,"attachmentType":"pdf","work_url":"https://www.academia.edu/88844995/6_Gingerol_a_Major_Ingredient_of_Ginger_Attenuates_Diethylnitrosamine_Induced_Liver_Injury_in_Rats_through_the_Modulation_of_Oxidative_Stress_and_Anti_Inflammatory_Activity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/88844995/6_Gingerol_a_Major_Ingredient_of_Ginger_Attenuates_Diethylnitrosamine_Induced_Liver_Injury_in_Rats_through_the_Modulation_of_Oxidative_Stress_and_Anti_Inflammatory_Activity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="36858403" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/36858403/Ginger_ingredients_inhibit_the_development_of_diethylnitrosoamine_induced_premalignant_phenotype_in_rat_chemical_hepatocarcinogenesis_model">Ginger ingredients inhibit the development of diethylnitrosoamine induced premalignant phenotype in rat chemical hepatocarcinogenesis model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34300836" href="https://aub-lb.academia.edu/MahmoudMansour">Mahmoud Mansour</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BioFactors, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Ginger ingredients inhibit the development of diethylnitrosoamine induced premalignant phenotype in rat chemical hepatocarcinogenesis model","attachmentId":56812531,"attachmentType":"pdf","work_url":"https://www.academia.edu/36858403/Ginger_ingredients_inhibit_the_development_of_diethylnitrosoamine_induced_premalignant_phenotype_in_rat_chemical_hepatocarcinogenesis_model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/36858403/Ginger_ingredients_inhibit_the_development_of_diethylnitrosoamine_induced_premalignant_phenotype_in_rat_chemical_hepatocarcinogenesis_model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="14112731" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14112731/Ginger_and_its_constituents_role_in_prevention_and_treatment_of_gastrointestinal_cancer">Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33114837" href="https://independent.academia.edu/SahdeoPrasad">Sahdeo Prasad</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Gastroenterology research and practice, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Gastrointestinal (GI) cancer, a cancer of different organs of the digestive system, is one of the most common cancers around the world. The incidence and death rate of some of these cancers are very high. Although a large variety of chemotherapeutic agents have been introduced since the last few decades to combat GI cancer, most of them are very expensive and have side effects. Therefore, the compounds derived from natural sources, which are considered to be safe and cost effective, are needed. Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating nausea, dysentery, heartburn, flatulence, diarrhea, loss of appetite, infections, cough, and bronchitis. Experimental studies showed that ginger and its active components including 6-gingerol and 6-shogaol exert anticancer activities against GI cancer. The anticancer activity of ginger is attributed to its ability to modulate several signaling molecules like NF-κB, STAT3,...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer","attachmentId":44591820,"attachmentType":"pdf","work_url":"https://www.academia.edu/14112731/Ginger_and_its_constituents_role_in_prevention_and_treatment_of_gastrointestinal_cancer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14112731/Ginger_and_its_constituents_role_in_prevention_and_treatment_of_gastrointestinal_cancer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="7035349" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/7035349/Molecular_targets_of_6_gingerol_Its_potential_roles_in_cancer_chemoprevention">Molecular targets of [6]-gingerol: Its potential roles in cancer chemoprevention</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="12005898" href="https://independent.academia.edu/AOYAGBEMI">ADEMOLA OYAGBEMI</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biofactors, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">A wide variety of phenolic compounds derived from spices possess potent antioxidant, anti-inflammatory, antimutagenic, and anticarcinogenic activities. [6]-gingerol (1-[4′-hydroxy-3′-methoxyphenyl]-5-hydroxy-3-decanone) is the major pungent principle of ginger, with numerous pharmacological properties including antioxidant, anti-inflammation, and antitumor promoting properties. It could decrease inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-α) expression through suppression of I-kappaB alpha (IκBα) phosphorylation, nuclear factor kappa B (NF-κB) nuclear translocation. Other antiproliferative mechanisms of [6]-gingerol include the release of Cytochrome c, Caspases activation, and increase in apoptotic protease-activating factor-1 (Apaf-1) as mechanism of apoptosis induction. Taken together, the chemopreventive potentials of [6]-gingerol present a promising future alternative to therapeutic agents that are expensive, toxic, and might even be carcinogenic.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular targets of [6]-gingerol: Its potential roles in cancer chemoprevention","attachmentId":48624970,"attachmentType":"pdf","work_url":"https://www.academia.edu/7035349/Molecular_targets_of_6_gingerol_Its_potential_roles_in_cancer_chemoprevention","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/7035349/Molecular_targets_of_6_gingerol_Its_potential_roles_in_cancer_chemoprevention"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":66228604,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":66228604,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_66228604" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="55673513" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55673513/Antioxidant_Anti_Inflammatory_and_Anticarcinogenic_Effects_of_Ginger_and_Its_Ingredients">Antioxidant, Anti-Inflammatory, and Anticarcinogenic Effects of Ginger and Its Ingredients</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="138586238" href="https://independent.academia.edu/marcoalonsogallegoscorona">marco alonso gallegos corona</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chemoprevention of Cancer and DNA Damage by Dietary Factors, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antioxidant, Anti-Inflammatory, and Anticarcinogenic Effects of Ginger and Its Ingredients","attachmentId":71434484,"attachmentType":"pdf","work_url":"https://www.academia.edu/55673513/Antioxidant_Anti_Inflammatory_and_Anticarcinogenic_Effects_of_Ginger_and_Its_Ingredients","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/55673513/Antioxidant_Anti_Inflammatory_and_Anticarcinogenic_Effects_of_Ginger_and_Its_Ingredients"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="102550904" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/102550904/Protective_and_therapeutic_potential_of_ginger_Zingiber_officinale_extract_and_6_gingerol_in_cancer_A_comprehensive_review">Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="176115374" href="https://independent.academia.edu/AmirulIslam212">Amirul Islam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Phytotherapy research : PTR, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review","attachmentId":102792172,"attachmentType":"pdf","work_url":"https://www.academia.edu/102550904/Protective_and_therapeutic_potential_of_ginger_Zingiber_officinale_extract_and_6_gingerol_in_cancer_A_comprehensive_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/102550904/Protective_and_therapeutic_potential_of_ginger_Zingiber_officinale_extract_and_6_gingerol_in_cancer_A_comprehensive_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="21573730" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21573730/Ginger_ingredients_reduce_viability_of_gastric_cancer_cells_via_distinct_mechanisms">Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42701563" href="https://independent.academia.edu/TakafumiAndo">Takafumi Ando</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms","attachmentId":42112779,"attachmentType":"pdf","work_url":"https://www.academia.edu/21573730/Ginger_ingredients_reduce_viability_of_gastric_cancer_cells_via_distinct_mechanisms","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/21573730/Ginger_ingredients_reduce_viability_of_gastric_cancer_cells_via_distinct_mechanisms"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="18786201" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18786201/6_Shogaol_Alkanone_from_Ginger_Induces_Apoptotic_Cell_Death_of_Human_Hepatoma_p53_Mutant_Mahlavu_Subline_via_an_Oxidative_Stress_Mediated_Caspase_Dependent_Mechanism">6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an Oxidative Stress-Mediated Caspase-Dependent Mechanism</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38866144" href="https://independent.academia.edu/ChungyiChen">Chung-yi Chen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Agricultural and Food Chemistry, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an Oxidative Stress-Mediated Caspase-Dependent Mechanism","attachmentId":40254353,"attachmentType":"pdf","work_url":"https://www.academia.edu/18786201/6_Shogaol_Alkanone_from_Ginger_Induces_Apoptotic_Cell_Death_of_Human_Hepatoma_p53_Mutant_Mahlavu_Subline_via_an_Oxidative_Stress_Mediated_Caspase_Dependent_Mechanism","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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href="https://www.academia.edu/4673096/Ginger_extract_Zingiber_officinale_triggers_apoptosis_and_G_0_G_1_cells_arrest_in_HCT_116_and_HT_29_colon_cancer_cell_lines"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="74509060" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74509060/The_Ginger_Family_Spicing_Up_the_Anticancer_Research">The Ginger Family : Spicing-Up the Anticancer Research</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="124440740" href="https://independent.academia.edu/JigyasaSomani">Jigyasa Somani</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2021</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Ginger Family : Spicing-Up the Anticancer Research","attachmentId":82636566,"attachmentType":"pdf","work_url":"https://www.academia.edu/74509060/The_Ginger_Family_Spicing_Up_the_Anticancer_Research","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/74509060/The_Ginger_Family_Spicing_Up_the_Anticancer_Research"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="94529285" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/94529285/Ginger_extract_activates_caspase_independent_paraptosis_in_cancer_cells_via_ER_stress_mitochondrial_dysfunction_AIF_translocation_and_DNA_damage">Ginger extract activates caspase independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="252357954" href="https://independent.academia.edu/AnupamaBinoy">Anupama Binoy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nutrition and Cancer, 2019</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="22581837" href="https://benha.academia.edu/SamyAziza">Samy Aziza</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats","attachmentId":57629481,"attachmentType":"pdf","work_url":"https://www.academia.edu/37643782/Role_of_Ginger_as_Anti_inflammatory_and_Anti_apoptotic_in_Protection_of_Liver_Damage_Induced_by_Metalaxyl_Fungicide_in_Male_Albino_Rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" 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Its Activity on Different Steps of the Metastatic Process</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33930659" href="https://ufscar.academia.edu/M%C3%A1rciaCominetti">Márcia R Cominetti</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33981597" href="https://ufscar.academia.edu/AngelinaFuzer">Angelina Fuzer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mini-Reviews in Medicinal Chemistry, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"[6]-gingerol as a Cancer Chemopreventive Agent: A Review of Its Activity on Different Steps of the Metastatic Process","attachmentId":43730995,"attachmentType":"pdf","work_url":"https://www.academia.edu/14938339/_6_gingerol_as_a_Cancer_Chemopreventive_Agent_A_Review_of_Its_Activity_on_Different_Steps_of_the_Metastatic_Process","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/14938339/_6_gingerol_as_a_Cancer_Chemopreventive_Agent_A_Review_of_Its_Activity_on_Different_Steps_of_the_Metastatic_Process"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="17017726" data-sort-order="default"><a 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href="https://www.academia.edu/17017726/6_Dehydrogingerdione_an_active_constituent_of_dietary_ginger_induces_cell_cycle_arrest_and_apoptosis_through_reactive_oxygen_species_c_Jun_N_terminal_kinase_pathways_in_human_breast_cancer_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="14938338" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14938338/Purification_and_differential_biological_effects_of_ginger_derived_substances_on_normal_and_tumor_cell_lines">Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author 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