临床癌症基因组学 |《自然-癌症》专题

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BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; white-space: normal; background-color: rgb(255, 255, 255); overflow-wrap: break-word !important;"><span style="text-align: justify;">基因测序和基因组学技术的发展正在迅速扩展我们对于癌症的了解，进而也推动了基因组学在临床肿瘤学中的应用。</span><span style="text-align: justify; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; color: rgb(27, 48, 81); overflow-wrap: break-word !important;"><em style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">Nature Cancer</strong></em></span><span style="text-align: justify;"> 期刊推出了一系列特约综述，讨论了基因组学研究目前在癌症诊断和治疗方面的指导作用，新兴技术的潜在作用，以及将新发现转化为临床应用的相关工作。</span><br/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); overflow-wrap: break-word !important;"><br/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); overflow-wrap: break-word !important;">本系列还包含发表在<span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; color: rgb(27, 48, 81);"><em style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">Nature Cancer</strong></em></span> 上与该主题相关的初步研究论文和新闻观点等。<br/><br/></p><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0052-4?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; color: rgb(219, 24, 48); overflow-wrap: break-word !important;">EDITORIAL</span> | SPOTLIGHT ON CANCER GENOMICS</span></a></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0052-4?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">社论：聚焦癌症基因组学</strong></span></a></p></section></section></section><p>癌症基因组学领域在以极快的速度发展，为转化应用开创了大量的可能性。在本期中，我们很高兴推出一系列特约文章，探讨基因组学在癌症研究和肿瘤学中的作用，从目前的成果到未来的方向。<br/><br/></p><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0043-5?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; color: rgb(219, 24, 48); overflow-wrap: break-word !important;">REVIEW ARTICLE</span><span style="color: rgb(31, 73, 125); margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; overflow-wrap: break-word !important;"> | CIRCULATING TUMOR DNA AND LIQUID BIOPSY IN ONCOLOGY</span></span></a></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0043-5?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">综述文章：肿瘤学中的肿瘤DNA循环和液体活组织检查</strong></span></a><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><br/></strong></p></section></section></section><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;">评估肿瘤DNA在血液中的循环已成为了肿瘤学领域的一项重要技术。Lillian Siu和他的同事们对液体活体组织检查可能的应用进行了综述，强调临床试验设计，从而实现其临床效用。</p></section></section></section><section><section><br/></section></section><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0033-7?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; color: rgb(219, 24, 48); overflow-wrap: break-word !important;">NEWS & VIEWS</span><span style="color: rgb(31, 73, 125); margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; overflow-wrap: break-word !important;"> | ONE SIZE DOES NOT FIT ALL FOR MUTATIONAL SIGNATURES</span></span></a></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0033-7?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">新闻观点：突变特征不能“一刀切”</strong><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"></strong></span></a></p></section></section></section><section><section><section><section>识别和分析癌症基因组中出现的突变模式能够提供有关肿瘤发生过程的重要信息。文章讨论了一个分析体系和一个基于网页的工具，旨在协助突变特征分析，进而改善肿瘤分层效果。<br/></section></section></section></section><section><section><br/></section></section><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0045-3?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; color: rgb(219, 24, 48); overflow-wrap: break-word !important;">CANCER IN TRANSLATION</span><span style="color: rgb(31, 73, 125); margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; overflow-wrap: break-word !important;"> | PROSPECTING WHOLE CANCER GENOMES</span></span></a></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0045-3?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">转化中的癌症：勘探完整癌症基因组</strong></span></a></p></section></section></section><section><section><section><section>泛癌症全基因组分析（Pan Cancer Analysis of Whole Genomes, PCAWG）联合会启动了一组新的研究，这组研究提供了至今为止分辨率最高的癌症基因组，扩充了我们对于驱动基因、突变特性、结构改变等方面的了解。Kreisberg、Ideker、Mills和Meric-Bernstam共同讨论了由此项目所得到的基础及转化方面的见解。<br/></section></section></section></section><section><section><br/></section></section><section><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-019-0008-8?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; color: rgb(219, 24, 48); overflow-wrap: break-word !important;">ARTICLE</span><span style="color: rgb(31, 73, 125); margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; overflow-wrap: break-word !important;"> | MULTIMODAL GENOMIC FEATURES PREDICT OUTCOME OF IMMUNE CHECKPOINT BLOCKADE IN NON-SMALL-CELL LUNG CANCER</span></span></a></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-019-0008-8?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">研究文章：非小细胞肺癌中免疫检查点阻塞的多模式基因组特性预测结果</strong></span></a></p></section></section></section></section><section><section><section><section>Anagnostou及团队展示了一种改良后的免疫检查点阻塞应答预测方法，这种方法可以整合肿瘤纯度、RTK基因组改变、吸烟相关突变特征以及HLA状态，得到修正后的肿瘤变异负荷量估值。<br/></section></section></section></section><section><section><br/></section></section><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0026-6?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; color: rgb(219, 24, 48); overflow-wrap: break-word !important;">ARTICLE</span><span style="color: rgb(31, 73, 125); margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; overflow-wrap: break-word !important;"> | IMAGING MASS CYTOMETRY AND MULTIPLATFORM GENOMICS DEFINE THE PHENOGENOMIC LANDSCAPE OF BREAST CANCER</span></span></a></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0026-6?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">研究文章：成像质谱流式和多平台基因组学揭示乳腺癌的表型基因组</strong></span></a></p></section></section></section><section><section><section><section>Bodenmiller及团队将成像质谱流式与METABRIC队列得到的数据相匹配，揭示了乳腺癌在空间背景中的单细胞表型和基因组特点，并发现了乳腺癌亚型和预后之间的联系。<br/></section></section></section></section><section><section><br/></section></section><section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; text-align: left; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0027-5?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><span style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; color: rgb(219, 24, 48); overflow-wrap: break-word !important;">ANALYSIS</span><span style="color: rgb(31, 73, 125); margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; text-align: justify; overflow-wrap: break-word !important;"> | A PRACTICAL FRAMEWORK AND ONLINE TOOL FOR MUTATIONAL SIGNATURE ANALYSES SHOW INTERTISSUE VARIATION AND DRIVER DEPENDENCIES</span></span></a></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><a href="https://www.nature.com/articles/s43018-020-0027-5?utm_source=naturechina&utm_medium=referral&utm_content=RMarketing&utm_campaign=JRCN_4_YD01_article" target="_self" style="color: rgb(31, 73, 125); text-decoration: underline;"><span style="color: rgb(31, 73, 125);"><strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;">分析：利用突变特征分析的实用体系和线上工具展示组织间变异和驱动依赖性</strong></span></a></p></section></section></section><section><section><section><section>Degasperi及团队介绍了一种实用体系和一个叫做Signal的线上工具，这两者可以用于分析变异特征。他们在变异特征中找到了组织特异性变异的证据，这一发现可能会影响肿瘤分类和临床应用。<br/></section></section></section><section><section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><br/></p><p style="margin-top: 0px; margin-bottom: 0px; white-space: normal; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; background-color: rgb(255, 255, 255); overflow-wrap: break-word !important;">《自然-癌症》四月份文章以癌症复杂性为主题，发表涵盖多个领域的论文，包括晚期癌症的基因组图谱，乳腺癌的治疗抗性，小细胞肺癌中的肿瘤内异质性以及白血病发展机制的研究。<br/><br/></p><p style="margin-top: 0px; margin-bottom: 0px; white-space: normal; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; background-color: rgb(255, 255, 255); overflow-wrap: break-word !important;"><img src="/upload/image/20210127/1611734562135673.jpg" title="1611734562135673.jpg" alt="33.jpg"/></p><p style="margin-top: 0px; margin-bottom: 0px; white-space: normal; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; background-color: rgb(255, 255, 255); overflow-wrap: break-word !important;"><br/>主编：Alexia-Ileana Zaromytidou</p><p style="margin-top: 0px; margin-bottom: 0px; white-space: normal; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; background-color: rgb(255, 255, 255); overflow-wrap: break-word !important;">邮箱：cancer@nature.com</p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; clear: both; min-height: 1em; overflow-wrap: break-word !important;"><br/></p></section></section></section><p><br/></p> </div> 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