Call for papers: Big data for randomized trials

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class="cms-item cms-article cleared" data-fragment="17443176"> <div class="cms-article__body cleared"> <p>Edited by: Dr Lars Hemkens</p><p><a href="https://trialsjournal.biomedcentral.com/" target="_blank" class="is-external"><em>Trials</em></a> invites you to submit to our new thematic series, ‘Big data for randomized trials’.</p><p>The Editors will consider articles that report on what is currently known about using big data or routinely collected data (such as electronic health records, registries or administrative databases) for randomized trials, the promises and limitations of using such data sources for trials and how we could make best use of them to improve clinical trial research for better patient care. </p><p>We encourage articles on any topic relevant to big data for conducting randomized trials on any level of health care. This includes articles describing the current knowledge about how using this data may make trials more feasible or would allow exploring research questions otherwise not possible to be explored , or which novel designs would be possible. Topics related to ethical implications, costs, or methodological aspects are very welcome. We are highly interested in empirical research on research studies. Commentaries and opinion pieces are welcome, especially those looking explicitly to practical challenges and offering solutions. All articles should make clear the relevance of using big data for randomized trials and current research gaps, and they should describe how the results or opinions in the article can be used to improve trial design and conduct in the future.</p><p class="align--left">Manuscripts should be formatted according to our <a href="http://trialsjournal.biomedcentral.com/submission-guidelines/preparing-your-manuscript" target="_self" class="is-external">submission guidelines</a> and submitted via the <a href="https://www.editorialmanager.com/trls/default.aspx" target="_self" class="is-external">online submission system</a>. In the submission system please make sure the correct collection title is chosen from the additional information tab. Please also indicate clearly in the covering letter that the manuscript is to be considered in the ‘Big data for randomized trials’ series.</p><p>For further information, please use the contact us email on the <a href="https://trialsjournal.biomedcentral.com/" target="_blank" class="is-external">journal website</a>.</p> </div> </div> <div id="articlelist-container"> <div data-total="14" data-test="search-content"> <ol class="c-listing" data-test="results-list"> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08668-8" data-track="select_search_result" data-track-context="bmc search results page or article listing">A qualitative study exploring stakeholders’ perceptions of registry-based randomised controlled trials capacity and capability in Australia</a> </h3> <p> Traditional randomised controlled trials (RCTs) are the gold standard for evaluating the effectiveness of interventions in clinical research. Traditional RCTs however are complex, expensive and have low extern... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Bill Karanatsios, Khic-Houy Prang, Justin M. Yeung and Peter Gibbs</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2024 <span>25</span>:834 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Methodology</span> <span data-test="published-on">Published on: <span itemprop="datePublished">18 December 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08668-8" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-024-08668-8" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-024-08668-8" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-024-08668-8.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07476-w" data-track="select_search_result" data-track-context="bmc search results page or article listing">Total laparoscopic partial hepatectomy versus open partial hepatectomy for primary left-sided hepatolithiasis: study protocol for a randomized controlled trial</a> </h3> <p> The advantages of laparoscopic left-sided hepatectomy (LLH) for treating hepatolithiasis in terms of the time to postoperative length of hospital stay (LOS), morbidity, long-term abdominal wall hernias, hospit... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Shu-bo Pan, Chun-li Wu, Da-chen Zhou, Qi-ru Xiong, Xiao-ping Geng and Hui Hou</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2024 <span>25</span>:137 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">22 February 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07476-w" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-023-07476-w" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-023-07476-w" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-023-07476-w.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-07918-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">Effectiveness of IT-supported patient recruitment: study protocol for an interrupted time series study at ten German university hospitals</a> </h3> <p> As part of the German Medical Informatics Initiative, the MIRACUM project establishes data integration centers across ten German university hospitals. The embedded MIRACUM Use Case “Alerting in Care - IT Suppo... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Martin Boeker, Daniela Zöller, Romina Blasini, Philipp Macho, Sven Helfer, Max Behrens, Hans-Ulrich Prokosch and Christian Gulden</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2024 <span>25</span>:125 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">16 February 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-07918-z" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-024-07918-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-024-07918-z" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-024-07918-z.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07820-0" data-track="select_search_result" data-track-context="bmc search results page or article listing">Preoperative dexamethasone administration in hepatectomy of 25-min intermittent Pringle’s maneuver for hepatocellular carcinoma: protocol for a randomized controlled trial</a> </h3> <p> Our previous randomized controlled trial (RCT) have demonstrated that intermittent Pringle’s maneuver (IPM) with a 25-min ischemic interval can be applied safely and efficiently in open or laparoscopic hepatec... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yang Huang, Liangliang Xu, Ning Wang, Xingyu Pu, Wentao Wang, Tianfu Wen, Mingqing Xu and Li Jiang</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2023 <span>24</span>:774 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">30 November 2023</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07820-0" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-023-07820-0" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> 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data-track="select_search_result" data-track-context="bmc search results page or article listing">Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial</a> </h3> <p> Recent studies have demonstrated a correlation between intestinal flora and the severity of myocardial infarction as well as post-myocardial infarction repair. However, few studies have investigated whether pr... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yequn Chen, Rongbing Chen, Xin Wang, Yan Zhou, Liekai Hong, Nianling Xiong, Jinxiu Zhu, Shu Ye and Xuerui Tan</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2023 <span>24</span>:429 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">24 June 2023</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07443-5" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-023-07443-5" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-023-07443-5" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-023-07443-5.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07411-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">Safety and efficacy in pediatric secondary intraocular lens implantation, in-the-bag versus sulcus implantation: a multicenter, single-blinded randomized controlled trial</a> </h3> <p> Treatment of pediatric cataract remains challenging because of the extremely high incidence of postoperative adverse events (AEs), especially the AEs related to the locations of secondary implanted intraocular... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yingshi Zou, Ling Jin, Bo Qu, Hui Chen, Mingbing Zeng, Xia Li, Xinhua Liu, Lixia Luo, Zhenzhen Liu and Yizhi Liu</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2023 <span>24</span>:388 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">9 June 2023</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07411-z" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-023-07411-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span 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data-track-context="bmc search results page or article listing">Safety and efficacy comparison of polyethylene glycol, hemp seed oil, and 5% sugar brine for bowel preparation in older patients: study protocol for a randomized controlled trial</a> </h3> <p> The incidence of colorectal cancer among the middle-aged and elderly is gradually increasing in China. Colonoscopy is an effective method for the early diagnosis of colorectal cancer, and bowel preparation is ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Xing Wang Zhu, Jun Yan, Long Miao, Ying Li He, Hai Ping Wang and Xun Li</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2023 <span>24</span>:168 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">6 March 2023</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-07059-1" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-022-07059-1" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-022-07059-1" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-022-07059-1.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06625-x" data-track="select_search_result" data-track-context="bmc search results page or article listing">Integrated traditional Chinese medicine intervention for delaying HIV morbidity: study protocol for a multicentre randomised controlled trial</a> </h3> <p> Acquired immune deficiency syndrome is caused by humans and is high worldwide. Active antiretroviral therapy emerged in the late 1990s and is effective against AIDS. However, despite the extensive research on ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Xue Ding, Pengfei Meng, Xiuxia Ma, Weifeng Cui, Liangping Li, Xiyuan Song, Jiangrong Wang, Chengjie Ma, Xin Chen and Liran Xu</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2022 <span>23</span>:665 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">17 August 2022</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06625-x" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-022-06625-x" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-022-06625-x" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-022-06625-x.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05141-8" data-track="select_search_result" data-track-context="bmc search results page or article listing">Using electronic patient records to assess the effect of a complex antenatal intervention in a cluster randomised controlled trial—data management experience from the DESiGN Trial team</a> </h3> <p> The use of electronic patient records for assessing outcomes in clinical trials is a methodological strategy intended to drive faster and more cost-efficient acquisition of results. The aim of this manuscript ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Sophie Relph, Maria Elstad, Bolaji Coker, Matias C. Vieira, Natalie Moitt, Walter Muruet Gutierrez, Asma Khalil, Jane Sandall, Andrew Copas, Deborah A. Lawlor and Dharmintra Pasupathy</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2021 <span>22</span>:195 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Methodology</span> <span data-test="published-on">Published on: <span itemprop="datePublished">8 March 2021</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05141-8" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-021-05141-8" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-021-05141-8" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-021-05141-8.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04403-1" data-track="select_search_result" data-track-context="bmc search results page or article listing">Core outcome sets through the healthcare ecosystem: the case of type 2 diabetes mellitus</a> </h3> <p> It is increasingly accepted that insufficient attention has been given to the patient health outcomes that are important to measure in comparative effectiveness research that will inform decision-making. The r... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Susanna Dodd, Nicola Harman, Nichole Taske, Mark Minchin, Toni Tan and Paula R. Williamson</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2020 <span>21</span>:570 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Commentary</span> <span data-test="published-on">Published on: <span itemprop="datePublished">25 June 2020</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04403-1" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-020-04403-1" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-020-04403-1" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-020-04403-1.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04329-8" data-track="select_search_result" data-track-context="bmc search results page or article listing">Access to routinely collected health data for clinical trials – review of successful data requests to UK registries</a> </h3> <p> Clinical trials generally each collect their own data despite routinely collected health data (RCHD) increasing in quality and breadth. Our aim is to quantify UK-based randomised controlled trials (RCTs) acces... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Sarah Lensen, Archie Macnair, Sharon B. Love, Victoria Yorke-Edwards, Nurulamin M. Noor, Meredith Martyn, Alexandra Blenkinsop, Carlos Diaz-Montana, Graham Powell, Elizabeth Williamson, James Carpenter and Matthew R. Sydes</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2020 <span>21</span>:398 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">12 May 2020</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04329-8" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-020-04329-8" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-020-04329-8" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-020-04329-8.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-4084-y" data-track="select_search_result" data-track-context="bmc search results page or article listing">Online randomized controlled experiments at scale: lessons and extensions to medicine</a> </h3> <p> Many technology companies, including Airbnb, Amazon, <span class="ExternalRef"><a href="http://booking.com"><span class="RefSource">Booking.com</span></a></span>, eBay, Facebook, Google, LinkedIn, Lyft, Microsoft, Netflix, Twitter, Uber, and Yahoo!/Oath, run online randomized controlled experiments at scale,... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Ron Kohavi, Diane Tang, Ya Xu, Lars G. Hemkens and John P. A. Ioannidis</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2020 <span>21</span>:150 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Methodology</span> <span data-test="published-on">Published on: <span itemprop="datePublished">7 February 2020</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-4084-y" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-020-4084-y" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-020-4084-y" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-020-4084-y.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3849-7" data-track="select_search_result" data-track-context="bmc search results page or article listing">A systematic review identifying common data items in neonatal trials and assessing their completeness in routinely recorded United Kingdom national neonatal data</a> </h3> <p> We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonata... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Sena Jawad, Neena Modi, A. Toby Prevost and Chris Gale</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2019 <span>20</span>:731 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Review</span> <span data-test="published-on">Published on: <span itemprop="datePublished">16 December 2019</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3849-7" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-019-3849-7" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Collection item" data-track-action="Download PDF" data-track-label="10.1186/s13063-019-3849-7" data-test="pdf-link" href="//trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-019-3849-7.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3847-9" data-track="select_search_result" data-track-context="bmc search results page or article listing">Electronic health record nested pragmatic randomized controlled trial of a reminder system for serum lithium level monitoring in patients with mood disorder: KONOTORI study protocol</a> </h3> <p> The weaknesses of classical explanatory randomized controlled trials (RCTs) include limited generalizability, high cost, and time burden. Pragmatic RCTs nested within electronic health records (EHRs) can be us... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Tomotsugu Seki, Morio Aki, Hirotsugu Kawashima, Tomotaka Miki, Shiro Tanaka, Koji Kawakami and Toshi A. Furukawa</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">Trials</em> 2019 <span>20</span>:706 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Study protocol</span> <span data-test="published-on">Published on: <span itemprop="datePublished">11 December 2019</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="//trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3847-9" data-track="select_search_result" data-track-category="Collection item" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13063-019-3847-9" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> 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