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What is Chemical Synthesis?
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class="clear_all"></div><div class="mediaDescription hide" style="max-width: 560px;width:100%;"></div></div></div></div></div><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">What is Chemical Synthesis?</h2><div class="text"><p>Chemical synthesis describes the physico-chemical transformation that occurs when two or more simpler molecules combine in a controlled fashion to produce a more complex chemical product. Often chemical synthesis is far more complex than A+B = C, and mixtures can occur containing product(s) and by-products.</p><p>Chemical synthesis is employed in the development of all commercially important products in pharmaceutical, polymer, fine and bulk chemical industries. The success of a chemical synthesis, which is defined as producing the target molecule with the correct economies and quality, is related to a efficient use of reactants and reagent via a thorough understanding and control of reaction variables. </p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0:after{content:"";display:table;clear:both}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 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.responsive-content-text-links,#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-image,#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-video{position:relative;float:none;clear:both;width:auto;box-sizing:border-box;margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-text-links{margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-text-wrap{text-align:initial}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-image{text-align:center;margin-top:15px;margin-right:0;margin-left:0;margin-bottom:15px}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .text-light .responsive-content-title,#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .text-light .responsive-content-text-wrap p{color:#666}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .responsive-content-title{margin-top:0}#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .repsponsive-content-link-wrap .simplelinklist a.white-link,#responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0 .repsponsive-content-link-wrap .simplelinklist a.white-link:hover{color:#004494;text-decoration:none}}</style><div class="responsive-content-wrapper subtle image-top" id="responsive-content-wrapper-9cbc03a1-3a5d-44ef-97bc-00f72ce69fb0" style="min-height:0px;"><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Modern Chemical Synthesis</h2><h3 class="responsive-content-subtitle"><strong>Comprehensive Understanding and Control</strong></h3><div class="text"><p>Modern chemical synthesis is responsible for all of the manufactured organic- and inorganic-based products that are developed to benefit civilization. Modern chemical synthesis requires that processes are well-understood, well-controlled, and produce results that meet economic, quality and safety objectives, while at the same time minimizing environmental impact.</p><p>Modern chemical synthesis employs sophisticated hardware and software to ensure the fundamental objectives of quality, safety, and yield are met. These tools extend from chemical development, where an understanding of reaction kinetics, thermodynamics, and the effect of reaction variables is fully characterized, to manufacturing where quality control and process stability are the keys to economic success. </p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf:after{content:"";display:table;clear:both}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf .responsive-content-image 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p{color:#fff}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf{background:0;background:-moz-linear-gradient(none,none,#fff);background:-webkit-linear-gradient(none,none,#fff);background:-o-linear-gradient(none,none,#fff);background:-ms-linear-gradient(none,none,#fff)}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf .responsive-content-video{position:absolute;z-index:1;left:0;margin-top:0;margin-bottom:0;margin-left:0;margin-right:0}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf .simplelinklist{margin-top:0}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf .simplelinklist ul li{font-size:1rem}.mt_direction_right_to_left .responsive-content-text-wrap{text-align:right!important}@media(max-width:768px){#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf{min-height:0!important;height:100%;overflow:hidden;margin:4px 2px 0 2px}#responsive-content-wrapper-57ab8600-b6ce-414b-94a0-fa2e90b87caf 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class="responsive-content-title">Chemical Synthesis Laboratory</h2><h3 class="responsive-content-subtitle"><strong>Beyond the Round Bottom Flask</strong></h3><div class="text"><p>The chemical synthesis lab has undergone significant changes in fairly recent years. The classic analog tools of chemical synthesis, such as round bottom flasks, heating mantles, cooling baths, stirring devices are rapidly being replaced by precise, digitally controlled synthesis technology such as automated laboratory reactors that result in far more reproducible reaction control.</p><p>The manner in which chemistry is performed is changing, as well. Classical chemical batch reactions are being replaced by continuous flow reactions that offer better yield, higher quality and safer reactions. In support of these new approaches to performing chemical synthesis, analytical equipment in the chemical synthesis lab has also changed. Offline, manual, wet chemical, and chromatography methods are rapidly giving way to online or inline real-time analysis. This direction of moving away from single point, offline measurement to data-rich, real-time analysis, supports one of the major trends in modern chemical synthesis – <a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_PAT/quality-by-design.html" target="_blank">Quality by Design</a> (QbD). </p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-89a6b129-5fc8-4cee-a504-c69b7aa5be9d{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-89a6b129-5fc8-4cee-a504-c69b7aa5be9d:after{content:"";display:table;clear:both}#responsive-content-wrapper-89a6b129-5fc8-4cee-a504-c69b7aa5be9d .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-89a6b129-5fc8-4cee-a504-c69b7aa5be9d .responsive-content-image 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class="responsive-content-title">Chemical Synthesis Technologies</h2><div class="text"><p>Modern chemical synthesis in both lab and production requires advanced technologies that meet the new requirements of quality, safety, and productivity. <a href="/sg/en/home/products/L1_AutochemProducts/chemical-synthesis-reactor-systems/EasyMax-Synthesis-Reactor.html" _rte_href="/sg/en/home/products/L1_AutochemProducts/chemical-synthesis-reactor-systems/EasyMax-Synthesis-Reactor.html" target="_blank">EasyMax</a><a href="/sg/en/home/products/L1_AutochemProducts/chemical-synthesis-reactor-systems.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/chemical-synthesis-reactor-systems.html">chemical synthesis reactor</a>, often equipped with calorimetric capability, is used in pharmaceutical and chemical development laboratories to optimize reaction variables, for faster scale-up, for measuring reaction thermodynamics and to ensure process safety. The automated laboratory reactor is a superior technology to support <a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/design-of-experiments-doe.html" target="_blank" _rte_href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/design-of-experiments-doe.html">Design of Experiment (DoE) applications</a> and other methods that mathematically relate experimental parameters and performance.</p><p>When particle size, form, and distribution are crucial, EasyViewer and ParticleTrack <a href="/sg/en/home/products/L1_AutochemProducts/particle-size-analyzers.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/particle-size-analyzers.html">particle size analyzers</a> are often used in conjunction with EasyMax. When offline testing is required, EasySampler automatically removes a reaction sample at pre-selected times and quench/dilutes it under reaction conditions for HPLC or other analyses. EasySampler operates unattended 24/7 and does not interrupt the reaction or affect reaction conditions. For real-time, in situ analysis, <a href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/ftir-spectrometers.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/ftir-spectrometers.html">ReactIR</a> and <a href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/raman-spectrometers.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/raman-spectrometers.html">Raman spectrometer</a> measurements are used for determining reaction kinetics, overall reaction progress, and to support proposed reaction mechanisms. These spectroscopic technologies provide a critical analytical data stream in both batch and continuous flow applications. </p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660:after{content:"";display:table;clear:both}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .mobile-image{display:none}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 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.responsive-content-text-links,#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-image,#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-video{position:relative;float:none;clear:both;width:auto;box-sizing:border-box;margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-text-links{margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-text-wrap{text-align:initial}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-image{text-align:center;margin-top:15px;margin-right:0;margin-left:0;margin-bottom:15px}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .text-light .responsive-content-title,#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .text-light .responsive-content-text-wrap p{color:#666}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .responsive-content-title{margin-top:0}#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .repsponsive-content-link-wrap .simplelinklist a.white-link,#responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660 .repsponsive-content-link-wrap .simplelinklist a.white-link:hover{color:#004494;text-decoration:none}}</style><div class="responsive-content-wrapper subtle image-top" id="responsive-content-wrapper-b5a4f7fb-8b8f-456d-a26e-f25769ea9660" style="min-height:0px;"><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Factors Influencing Chemical Synthesis</h2><div class="text"><ul><li><b>Quality of Reactants, Reagents, and Catalysts </b>– The quality of starting materials and stable sources/vendors of those materials is key to successful, reproducible <a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html" _rte_href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html" target="_blank">synthesis reactions and processes</a>.<br><br></li><li><b>Reaction Conditions </b>– Since <a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html" _rte_href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html">chemical synthesis reactions</a> are sensitive to parameters such as reaction temperature, pressure, agitation rate and dosing rate, precise and accurate control of these variables is crucial to a successful outcome. EasyMax provides automated parameter control, accuracy, and precision of reaction variables.<br><br></li><li><b>Reaction Equipment</b> – In the pharmaceutical industry, most chemical syntheses are performed in batch mode, but <a href="/sg/en/home/applications/L1_AutoChem_Applications/continuous.html" _rte_href="/sg/en/home/applications/L1_AutoChem_Applications/continuous.html">continuous flow processes</a> are becoming increasingly more frequent. The bulk chemical industry has used continuous flow processes for years. ReactIR in-situ analysis supports both batch and continuous flow syntheses. The physical configuration of EasyMax reactors are an improvement over the classic round bottom flask due to surface area and agitation efficiency considerations<br><br></li><li><b>Reaction Kinetics</b> – A thorough understanding of reaction rates are crucial to ensure optimized product yield and minimum by-products. Through data-rich experiments, in-situ analyses via ReactIR and ReactRaman simplify and speed the measurement of kinetic factors in synthesis reactions, as well as provides support for proposed reaction mechanisms. When off-line analysis is preferable, EasySampler automatically removes a sample from the reaction mixture at pre-selected times and quench/dilutes it for HPLC or other analyses. EasySampler removes the sample without interrupting the synthesis or disturbing reaction conditions. <br><br></li><li><b>Product Isolation/Purity</b> – Though advanced separation techniques are a mainstay for product isolation and purity, a thorough understanding of the effect of reaction variables to reduce the presence of impurities that may be difficult to separate for product is important. By optimizing reaction variables, ReactIR with EasyMax aid impurity reduction. As equally important, a thorough understanding and control of crystallization via ParticleTrack and EasyViewer technology is critical to ensuring purity and ease of isolating desired products.<br><br></li><li><b>Safety</b> – Commercially-important chemical synthesis requires lab-to-plant protocols that provide both optimized yield, acceptable impurity profiles, and safe operation. ReactIR advances reaction scale-up by elucidating the effects of reaction variables on overall chemical synthesis performance. Calorimetry ensures safe reactions from screening, through scale-up to process by measuring heats of reaction. ReactIR minimizes exposure of scientists and technicians to toxic chemicals and potentially hazardous reactions by eliminating grab sampling for offline analysis. When offline analysis is required, EasySampler provides automated, in-situ sampling and dilution of samples for HPLC, eliminating worker exposure.</li></ul></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-48a33ac4-1cb1-4f96-b676-49ecbc5d536f{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-48a33ac4-1cb1-4f96-b676-49ecbc5d536f:after{content:"";display:table;clear:both}#responsive-content-wrapper-48a33ac4-1cb1-4f96-b676-49ecbc5d536f .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-48a33ac4-1cb1-4f96-b676-49ecbc5d536f .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-48a33ac4-1cb1-4f96-b676-49ecbc5d536f .mobile-image{display:none}#responsive-content-wrapper-48a33ac4-1cb1-4f96-b676-49ecbc5d536f 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srcset="/dam/autochem/applications/chemical-process-development/chemical-synthesis-worksation-492x364.jpg/_jcr_content/renditions/cq5dam.web.320.640.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/autochem/applications/chemical-process-development/chemical-synthesis-worksation-492x364.jpg/_jcr_content/renditions/cq5dam.web.480.480.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/autochem/applications/chemical-process-development/chemical-synthesis-worksation-492x364.jpg/_jcr_content/renditions/cq5dam.web.480.800.jpeg" media="(min-width: 321px) and (max-width: 480px)" type="image/jpeg"><source srcset="/dam/autochem/applications/chemical-process-development/chemical-synthesis-worksation-492x364.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/autochem/applications/chemical-process-development/chemical-synthesis-worksation-492x364.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/autochem/applications/chemical-process-development/chemical-synthesis-worksation-492x364.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" src="/dam/autochem/applications/chemical-process-development/chemical-synthesis-worksation-492x364.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="chemical synthesis workstation" title="chemical synthesis workstation"></picture></div><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Better Chemical Synthesis</h2><h3 class="responsive-content-subtitle"><strong>Comprehensive, Fit-for-Purpose Technology to Advance Chemical Synthesis</strong></h3><div class="text"><ul><li><a href="/sg/en/home/products/L1_AutochemProducts/chemical-synthesis-reactor-systems/" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/chemical-synthesis-reactor-systems/">Chemical Reactors</a> - for precise, automated control of reaction parameters<br><br></li><li><a href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/ftir-spectrometers.html" _rte_href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/ftir-spectrometers.html" target="_blank">ReactIR</a> and <a href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/raman-spectrometers.html" _rte_href="/sg/en/home/products/L1_AutochemProducts/ftir-and-raman-spectrometers/raman-spectrometers.html" target="_blank">ReactRaman</a> Spectrometers – real-time tracking and profiling of key reaction species as a function of reaction time to aid kinetics and mechanistic investigations<br><br></li><li>EasySampler – <a href="/sg/en/home/products/L1_AutochemProducts/automated-sampling-systems.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/automated-sampling-systems.html">automated sampling</a> of reactions when offline analysis is required<br><br></li><li><a href="/sg/en/home/products/L1_AutochemProducts/particle-size-analyzers.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/particle-size-analyzers.html">Particle Size Analyzers</a> – in situ monitoring and measurement of crystals, particles, and <a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_Crystallization.html" target="_blank" _rte_href="/sg/en/home/applications/L1_AutoChem_Applications/L2_Crystallization.html">crystallization processes</a></li></ul><p>Individually, or as an integrated chemical workstation, provides critical support for better <a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html" target="_blank" _rte_href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html">synthesis reactions</a>.</p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-bd748f86-aa8e-4ab1-b4b7-3ef52e4427fe{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-bd748f86-aa8e-4ab1-b4b7-3ef52e4427fe:after{content:"";display:table;clear:both}#responsive-content-wrapper-bd748f86-aa8e-4ab1-b4b7-3ef52e4427fe .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-bd748f86-aa8e-4ab1-b4b7-3ef52e4427fe .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-bd748f86-aa8e-4ab1-b4b7-3ef52e4427fe .mobile-image{display:none}#responsive-content-wrapper-bd748f86-aa8e-4ab1-b4b7-3ef52e4427fe 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class="responsive-content-text-wrap"><div class="text"><p><a href="/sg/en/home/products/L1_AutochemProducts.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts.html">Process Development and Scale-up workstations</a> provide thermodynamic data in real time, the ability to investigate the impact of changing conditions on heat and mass transfer and support studies related to concentrations, temperature, or kinetics. <a href="/sg/en/home/products/L1_AutochemProducts/reaction-calorimeters/RC1mx-Reaction-Calorimeter.html" target="_blank" _rte_href="/sg/en/home/products/L1_AutochemProducts/reaction-calorimeters/RC1mx-Reaction-Calorimeter.html">Reaction calorimeters</a> allow researchers to measure heat generated by a reaction and to control the reaction based on heat output. The control of the relevant parameters including additions can be automated and pre-programmed, so experiments can be safely run while recording all reaction parameters, 24 hours a day. The individual steps of the process of the polymerization reaction together with the experimental data are continuously recorded and stored securely making them available for evaluation and interpretation. Due to the safe, highly accurate, and precise measurement and control, the number of experiments required is reduced – making scale-up efficient.</p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-713da94a-1b7b-4327-be9c-8adc62c1da4c{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-713da94a-1b7b-4327-be9c-8adc62c1da4c:after{content:"";display:table;clear:both}#responsive-content-wrapper-713da94a-1b7b-4327-be9c-8adc62c1da4c .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-713da94a-1b7b-4327-be9c-8adc62c1da4c .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-713da94a-1b7b-4327-be9c-8adc62c1da4c .mobile-image{display:none}#responsive-content-wrapper-713da94a-1b7b-4327-be9c-8adc62c1da4c 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id="mediaContainerWrapper_463384876" style="max-width: 435px; width: 100%"><div class="mediaContainer embeddedVideoPreloading" data-external-url="https://youtu.be/CCSdW56anew" id="mediaContainer_463384876" style="width: 435px; height:315px" data-advanced-option="false" data-width="435" data-height="315" data-video-id="CCSdW56anew"><button class="mt-btn-link" id="mediaVideoButton_463384876" rel="nofollow"><div class="mediaPreviewImage"><picture><img loading="lazy" loading="lazy" src="/dam/AutoChem_Media_Library/AutoChem_img.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" height="315" width="100%" id="previewImage_463384876"></picture><span class="mediaVideoIcon"></span></div></button></div></div><div class="clear_all"></div><div class="mediaDescription hide" style="max-width: 435px;width:100%;"></div></div></div></div></div><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Inline Sampling of Chemical Synthesis</h2><div class="text"><p><a href="/sg/en/home/products/L1_AutochemProducts/automated-sampling-systems.html" _rte_href="/sg/en/home/products/L1_AutochemProducts/automated-sampling-systems.html" target="_blank">EasySampler</a> provides representative samples over the entire reaction. Accurate, reproducible, and representative samples provide high-quality HPLC results. This makes it easy to study reaction kinetics and develop <a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Impurity-Profiling-of-Chemical-Reactions.html" target="_blank" _rte_href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Impurity-Profiling-of-Chemical-Reactions.html">impurity profiles</a>, even from heterogeneous mixtures, air- and moisture-sensitive reactions, and reactions under pressurize and toxic conditions. At user-defined time points, EasySampler automatically captures reaction samples, quenches samples immediately and at reaction conditions, and finally dilutes the sample to a user-specified concentration. </p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-22a2a4f7-216a-4310-87f8-45b79f58545e{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:0}#responsive-content-wrapper-22a2a4f7-216a-4310-87f8-45b79f58545e:after{content:"";display:table;clear:both}#responsive-content-wrapper-22a2a4f7-216a-4310-87f8-45b79f58545e .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-22a2a4f7-216a-4310-87f8-45b79f58545e .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-22a2a4f7-216a-4310-87f8-45b79f58545e 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srcset="/dam/autochem/applications/chemical-process-development/spectrometers-chemical-synthesis.jpg/_jcr_content/renditions/cq5dam.web.320.640.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/autochem/applications/chemical-process-development/spectrometers-chemical-synthesis.jpg/_jcr_content/renditions/cq5dam.web.480.480.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/autochem/applications/chemical-process-development/spectrometers-chemical-synthesis.jpg/_jcr_content/renditions/cq5dam.web.480.800.jpeg" media="(min-width: 321px) and (max-width: 480px)" type="image/jpeg"><source srcset="/dam/autochem/applications/chemical-process-development/spectrometers-chemical-synthesis.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/autochem/applications/chemical-process-development/spectrometers-chemical-synthesis.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/autochem/applications/chemical-process-development/spectrometers-chemical-synthesis.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" src="/dam/autochem/applications/chemical-process-development/spectrometers-chemical-synthesis.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="Spectrometers for Chemical Synthesis" title="Spectrometers for Chemical Synthesis"></picture></div><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Enhance Understanding of Chemical Synthesis with In-Situ Spectroscopy</h2><div class="text"><p>The infrared spectrometer for real-time monitoring of chemical reactions directly in the reaction vessel or flow reactor. Gain in-depth information about reaction kinetics, mechanism and pathways.</p><ul><li>Develop real-time trending profiles for key reaction species: reactants, intermediates, products, by-products<br><br></li><li>Obtain data-rich information for traditional kinetic analysis or Reaction Progress Kinetics Analysis (RPKA) methods<br><br></li><li>Monitor reactions where removing a sample for offline analysis is difficult, impossible or undesirable – low temperature, elevated temperature/pressure, viscous, toxic reagents, highly energetic reactions, air/moisture sensitive, transient intermediates<br><br></li><li>Investigate key stages of a reaction or process such as reaction start, induction period, accumulation, conversion, endpoint. Detect reaction stalling or upset.</li></ul></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:solid 1px #e6e6e6}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71:after{content:"";display:table;clear:both}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .mobile-image{display:none}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 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.responsive-content-video{position:absolute;z-index:1;left:0;margin-top:0;margin-bottom:0;margin-left:0;margin-right:0}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .simplelinklist{margin-top:0}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .simplelinklist ul li{font-size:1rem}.mt_direction_right_to_left .responsive-content-text-wrap{text-align:right!important}@media(max-width:768px){#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71{min-height:0!important;height:100%;overflow:hidden;margin:4px 2px 0 2px}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .show-on-mobile{display:block}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .hide-on-mobile,#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-image .imageGradient{display:none}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-text-links,#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-image,#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-video{position:relative;float:none;clear:both;width:auto;box-sizing:border-box;margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-text-links{margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-text-wrap{text-align:initial}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-image{text-align:center;margin-top:15px;margin-right:0;margin-left:0;margin-bottom:15px}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .text-light .responsive-content-title,#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .text-light .responsive-content-text-wrap p{color:#666}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .responsive-content-title{margin-top:0}#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .repsponsive-content-link-wrap .simplelinklist a.white-link,#responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71 .repsponsive-content-link-wrap .simplelinklist a.white-link:hover{color:#004494;text-decoration:none}}</style><div class="responsive-content-wrapper subtle image-top" id="responsive-content-wrapper-138d0bb8-4d04-4403-b824-1712eb67cc71" style="min-height:0px;"><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Featured Article: Chemical Synthesis – Catalysis</h2><h3 class="responsive-content-subtitle"><strong>Kinetic and Mechanistic Insights</strong></h3><div class="text"><p><b>Niklas O. Thiel, Benyapa Kaewmee, Trung Tran Ngoc, Johannes F. Teichert, “A Simple Nickel Catalyst Enables Broad E-Selective Alkyne Semihydrogenation,” Chem. Euro J.</b><br><br>The authors use nickel catalyst [NiI<sub>2</sub>] and 1,1'bis(diphenylphosphino)ferrocene (dppf)] to perform <i>E</i>-selective alkyne semihydrogenations on a range of substrates with a variety of aryl and alkyl substitution patterns. They show that this commercially available nickel catalyst enables the <i>E</i>‐selective alkyne semihydrogenation of a broad range of substituted alkynes.</p><p> ReactIR measurements performed under 30 bar H<sub>2</sub> provided kinetic data and support for proposed mechanism. Initially Z-selective alkyne semihydrogenation occurs as the reaction vessel is warming. Formation of E-stilbene is observed when the temperature reaches 80C after 90 minutes, and after several hours the E-stilbene is the major product. The ReactIR data suggests that two different mechanisms occur. The first mechanism leads to the Z-selective alkyne semihydrogenation; the second is a Z to E isomerization mechanism, associated with Ni hydride intermediates. </p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:solid 1px #e6e6e6}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90:after{content:"";display:table;clear:both}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 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.responsive-content-text-links,#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-image,#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-video{position:relative;float:none;clear:both;width:auto;box-sizing:border-box;margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-text-links{margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-text-wrap{text-align:initial}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-image{text-align:center;margin-top:15px;margin-right:0;margin-left:0;margin-bottom:15px}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .text-light .responsive-content-title,#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .text-light .responsive-content-text-wrap p{color:#666}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .responsive-content-title{margin-top:0}#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .repsponsive-content-link-wrap .simplelinklist a.white-link,#responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90 .repsponsive-content-link-wrap .simplelinklist a.white-link:hover{color:#004494;text-decoration:none}}</style><div class="responsive-content-wrapper subtle image-top" id="responsive-content-wrapper-519ad9b2-853e-4b61-852b-cbea8b5cca90" style="min-height:0px;"><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Featured Article: Chemical Synthesis – Polymers</h2><h3 class="responsive-content-subtitle"><strong>Investigate Kinetics and Optimize Reaction Variables</strong></h3><div class="text"><p><b>Wen Tian, Rongrong Hu, and Ben Zhong Tang, “One-Pot Multicomponent Tandem Reactions and Polymerizations for Step-Economic Synthesis of Structure-Controlled Pyrimidine Derivatives and Poly(pyrimidine)s”, Macromolecules 2018, 51, 9749−9757.</b></p><p>The researchers report the development of one-pot multicomponent tandem polymerization reactions (MCTP) that enable the synthesis of conjugated poly(pyrimidine)s with specific properties. They show that the polymerizations are performed using a diyne, guanidine HCl, DMSO and O<sub>2 </sub>in the presence of CuCl, Cs<sub>2</sub>CO<sub>3</sub> and N,N,N’,N’-tetramethylethylenediamine.</p><p>In situ FTIR experiments provided data for determining reaction kinetics and MCPT reaction time optimization parameters. ReactIR tracks key species in MCTP of P1 (under air) and P2 (under nitrogen) as a function of time. In the former, band at 1662 cm-1 increases due to formation of carbonyl group; in the latter band at 1662 cm-2 decreases since a carbonyl functionality is not present.</p></div></div></div></div></div><div class="responsivefeaturecontent section"><style>#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157{position:relative;background-color:none;margin-top:0;overflow:hidden;margin-bottom:4px;border:solid 1px #e6e6e6}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157:after{content:"";display:table;clear:both}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-image{position:absolute;z-index:0;max-width:100%;right:0;margin-top:0;margin-right:0;margin-bottom:0;margin-left:0}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-image img{max-width:100%;height:auto}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 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.responsive-content-text-links,#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-image,#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-video{position:relative;float:none;clear:both;width:auto;box-sizing:border-box;margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-text-links{margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-text-wrap{text-align:initial}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-image{text-align:center;margin-top:15px;margin-right:0;margin-left:0;margin-bottom:15px}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .text-light .responsive-content-title,#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .text-light .responsive-content-text-wrap p{color:#666}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .responsive-content-title{margin-top:0}#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .repsponsive-content-link-wrap .simplelinklist a.white-link,#responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157 .repsponsive-content-link-wrap .simplelinklist a.white-link:hover{color:#004494;text-decoration:none}}</style><div class="responsive-content-wrapper subtle image-top" id="responsive-content-wrapper-1bbf1ea6-5e57-42af-8bd8-1e12cc7fc157" style="min-height:0px;"><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Featured Article: Chemical Synthesis – Pharmaceutical Intermediate</h2><h3 class="responsive-content-subtitle"><strong>Improved Process Understanding</strong></h3><div class="text"><p><b>Kallakuri Suparna Rao, Frédéric St-Jean, and Archana Kumar, “Quantitation of a Ketone Enolization and a Vinyl Sulfonate Stereoisomer Formation Using Inline IR Spectroscopy and Modeling”, Org. Process Res. Dev. 2019, 23, 945−951.</b></p><p>The authors report using ReactIR to study the formation of an important vinyl sulfonate intermediate in an API, which has an acyclic tetrasubstituted all-carbon olefin. Via univariate and multivariate modeling, the in situ ReactIR data enabled real-time monitoring of the consumption and quantitative conversion of the ketone, the formation of the metal enolates, as well as quantitation of a minor stereoisomer in a product mixture of tetrasubstituted vinyl sulfonate stereoisomers. The models were validated using IR data acquired over a range of experimental conditions</p><p>To optimize the quantitative results, the ReactIR probe was used in combination with an EasyMax automated lab reactor in order to ensure precise control over parameters such as temperature, stirring rate and reaction time.</p></div></div></div></div></div></div></div></div><div class="ptab-content applications" data-tab-name="applications" id="applications"><h3 class="ptabs_accordion_header simple-accordion_header simple-accordion_header-large"><span class="accordion_expander simple-accordion_icon"></span>Applications</h3><div class="ptab-content-body"><h3>Synthetic Organic Chemistry Applications</h3><div class="mask"></div><div class="overview_content"><div class="afapplicationspar parsys"><div class="productfamilycomparison section"><link rel="stylesheet" href="/etc/designs/mt/widgets/misc/productfamilycomparison.min-v54.css" type="text/css"><script src="/etc/designs/mt/widgets/misc/productfamilycomparison.min-v54.js"></script> <link rel="stylesheet" href="/etc/designs/mt/widgets/misc/linklist.min-v54.css" type="text/css"><div class="productFamilyComparison blockLayout" data-see-more-label="Read more"><div class="link_blocks"><div class="link_block" data-productpage="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Controlling-Residual-Isocyanate.html"><div class="link_image"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Controlling-Residual-Isocyanate.html" data-width="300"><picture><source srcset="/dam/product_organizations/autochem/isocyanate2016/Isocyanate_Thumb.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><img loading="lazy" src="/dam/product_organizations/autochem/isocyanate2016/Isocyanate_Thumb.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="Control Residual Isocyanate" title="Control Residual Isocyanate"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Controlling-Residual-Isocyanate.html"> Isocyanate Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocya... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Controlling-Residual-Isocyanate.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Controlling-Residual-Isocyanate.fb.1.cs.13.html"><button 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class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Impurity-Profiling-of-Chemical-Reactions.html"> Impurity Profiling of Chemical Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Impurity profiling aims at identification and subsequent quantification of specific components present at low levels, usually less than 1% and ideally lower than 0.1 %. </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Impurity-Profiling-of-Chemical-Reactions.html"> See details 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srcset="/dam/0autochem/grignard-reaction.jpg/_jcr_content/renditions/original.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/0autochem/grignard-reaction.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/0autochem/grignard-reaction.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/0autochem/grignard-reaction.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" src="/dam/0autochem/grignard-reaction.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="Grignard Reaction Mechanisms" title="Grignard Reaction Mechanisms"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.html"> Grignard Reaction Mechanisms </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.fb.1.cs.13.html"><button data-href="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.fb.1.cs.13.html" class="fb-button-p5a blue small" data-swiftype-index="false"> Request Info </button></form></div></div><div class="familyMobile_tabNavigation"><ul><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.html">Overview</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.html#applications">Applications</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.html#publications">Publications</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Grignard_application.html#productsolutions">Related Products</a></li></ul></div><div class="familyMobile_seeLess"><a class="text-collapse-link text-collapse-see-less"><span class="collapse-arrow collapse-arrow-up"></span>See less</a></div></div></div></div><div class="link_block" data-productpage="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction_Analysis_Hydrogenation.html"><div class="link_image"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction_Analysis_Hydrogenation.html" data-width="300"><picture><source srcset="/dam/product_organizations/autochem/hydrogenation/Hydrogenations-Reactions-Monitoring.jpg/_jcr_content/renditions/cq5dam.web.240.240.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/product_organizations/autochem/hydrogenation/Hydrogenations-Reactions-Monitoring.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/product_organizations/autochem/hydrogenation/Hydrogenations-Reactions-Monitoring.jpg/_jcr_content/renditions/original.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/product_organizations/autochem/hydrogenation/Hydrogenations-Reactions-Monitoring.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/product_organizations/autochem/hydrogenation/Hydrogenations-Reactions-Monitoring.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/product_organizations/autochem/hydrogenation/Hydrogenations-Reactions-Monitoring.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" src="/dam/product_organizations/autochem/hydrogenation/Hydrogenations-Reactions-Monitoring.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="Hydrogenation Reactions" title="Hydrogenation Reactions"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction_Analysis_Hydrogenation.html"> Hydrogenation Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Hydrogenation reactions are used in the manufacturing of both bulk and fine chemicals for reducing multiple bonds to single bonds. Catalysts are typically used to promote these reactions and reaction... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction_Analysis_Hydrogenation.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction_Analysis_Hydrogenation.fb.1.cs.13.html"><button 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data-productpage="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Highly_Reactive_Chemistry.html"><div class="link_image"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Highly_Reactive_Chemistry.html" data-width="93"><picture><img loading="lazy" src="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Highly_Reactive_Chemistry/_jcr_content/thumbnailImage.webImage.file.png" alt="Highly Reactive Chemistries" title="Highly Reactive Chemistries"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Highly_Reactive_Chemistry.html"> Highly Reactive Chemistries </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Highly reactive chemistry is a terminology used to describe chemical reactions that are particularly challenging to handle and develop due to the potentially hazardous and/or energetic nature of the r... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Highly_Reactive_Chemistry.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Highly_Reactive_Chemistry.fb.1.cs.13.html"><button data-href="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Highly_Reactive_Chemistry.fb.1.cs.13.html" 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src="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure/_jcr_content/thumbnailImage.webImage.file.png" alt="High Pressure Reactions" title="High Pressure Reactions"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure.html"> High Pressure Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Many processes require reactions to be run under high pressure. Working under pressure is challenging and collecting samples for offline analysis is difficult and time consuming. A change in pressure... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure.fb.1.cs.13.html"><button data-href="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure.fb.1.cs.13.html" class="fb-button-p5a blue small" data-swiftype-index="false"> Request Info </button></form></div></div><div class="familyMobile_tabNavigation"><ul><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure.html">Overview</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure.html#publications">Publications</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Reaction-Analysis_High_Pressure.html#productsolutions">Related Products</a></li></ul></div><div class="familyMobile_seeLess"><a class="text-collapse-link text-collapse-see-less"><span class="collapse-arrow collapse-arrow-up"></span>See less</a></div></div></div></div><div class="link_block" data-productpage="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.html"><div class="link_image"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.html" data-width="0"><picture><img loading="lazy" src="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations/_jcr_content/thumbnailImage.webImage.file.png" alt="Halogenation Reactions" title="Halogenation Reactions"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.html"> Halogenation Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Halogenation occurs when one of more fluorine, chlorine, bromine, or iodine atoms replace one or more hydrogen atoms in an organic compound. Depending on the specific halogen, the nature of the substr... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.fb.1.cs.13.html"><button data-href="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.fb.1.cs.13.html" class="fb-button-p5a blue small" data-swiftype-index="false"> Request Info </button></form></div></div><div class="familyMobile_tabNavigation"><ul><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.html">Overview</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.html#applications">Applications</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Halogenations.html#publications">Publications</a></li></ul></div><div class="familyMobile_seeLess"><a class="text-collapse-link text-collapse-see-less"><span class="collapse-arrow collapse-arrow-up"></span>See less</a></div></div></div></div><div class="link_block" data-productpage="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Catalytic-Reactions.html"><div class="link_image"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Catalytic-Reactions.html" data-width="300"><picture><source srcset="/dam/AutoChem_Media_Library/Catalytic-Reactions.jpg/_jcr_content/renditions/cq5dam.web.240.240.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/AutoChem_Media_Library/Catalytic-Reactions.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/AutoChem_Media_Library/Catalytic-Reactions.jpg/_jcr_content/renditions/original.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/AutoChem_Media_Library/Catalytic-Reactions.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/AutoChem_Media_Library/Catalytic-Reactions.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/AutoChem_Media_Library/Catalytic-Reactions.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" src="/dam/AutoChem_Media_Library/Catalytic-Reactions.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="Catalytic Reactions" title="Catalytic Reactions"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Catalytic-Reactions.html"> Catalyzed Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Catalysts create an alternative path to increase the speed and outcome of a reaction, so a thorough understanding of the reaction kinetics is important. Not only does that provide information about th... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Catalytic-Reactions.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Catalytic-Reactions.fb.1.cs.13.html"><button data-href="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Catalytic-Reactions.fb.1.cs.13.html" class="fb-button-p5a blue small" data-swiftype-index="false"> Request Info </button></form></div></div><div class="familyMobile_tabNavigation"><ul><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/Catalytic-Reactions.html">Overview</a></li></ul></div><div class="familyMobile_seeLess"><a class="text-collapse-link text-collapse-see-less"><span class="collapse-arrow collapse-arrow-up"></span>See less</a></div></div></div></div><div class="link_block" data-productpage="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html"><div class="link_image"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html" data-width="300"><picture><source srcset="/dam/autochem/applications/synthesis-reactions/synthesis-reaction-thumbnail-300x185.jpg/_jcr_content/renditions/cq5dam.web.240.240.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/autochem/applications/synthesis-reactions/synthesis-reaction-thumbnail-300x185.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><source srcset="/dam/autochem/applications/synthesis-reactions/synthesis-reaction-thumbnail-300x185.jpg/_jcr_content/renditions/original.webp" media="(min-width: 321px) and (max-width: 480px)" type="image/webp"><source srcset="/dam/autochem/applications/synthesis-reactions/synthesis-reaction-thumbnail-300x185.jpg/_jcr_content/renditions/original.webp" media="(min-width: 481px) and (max-width: 640px)" type="image/webp"><source srcset="/dam/autochem/applications/synthesis-reactions/synthesis-reaction-thumbnail-300x185.jpg/_jcr_content/renditions/original.webp" media="(min-width: 641px) and (max-width: 800px)" type="image/webp"><source srcset="/dam/autochem/applications/synthesis-reactions/synthesis-reaction-thumbnail-300x185.jpg/_jcr_content/renditions/original.webp" media="(min-width: 801px)" type="image/webp"><img loading="lazy" src="/dam/autochem/applications/synthesis-reactions/synthesis-reaction-thumbnail-300x185.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="synthesis reactions" title="synthesis reactions"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/synthesis-reactions.html"> Synthesis Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> A synthesis reaction is a chemical process in which simple elements or compounds combine to form a more complex product. 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class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/c-h-activation-reactions.html"> C-H Activation Reactions </a></h3><div class="link_description familyDescription"><span class="link_description_text"> C-H bond activation is a series of mechanistic processes by which stable carbon-hydrogen bonds in organic compounds are cleaved. </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/c-h-activation-reactions.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div 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Click reactions are typically fast, high-yielding, and occur under mild conditions, making them ideal for a varie... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/click-chemistry-tools-click-reactions.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/click-chemistry-tools-click-reactions.fb.1.cs.13.html"><button data-href="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/click-chemistry-tools-click-reactions.fb.1.cs.13.html" class="fb-button-p5a blue small" data-swiftype-index="false"> Request Info </button></form></div></div><div class="familyMobile_tabNavigation"><ul><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/click-chemistry-tools-click-reactions.html">Overview</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/click-chemistry-tools-click-reactions.html#applications">Click Reaction Examples in Industry</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/click-chemistry-tools-click-reactions.html#publications">Citations and References</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/click-chemistry-tools-click-reactions.html#custom5">FAQs</a></li></ul></div><div class="familyMobile_seeLess"><a class="text-collapse-link text-collapse-see-less"><span class="collapse-arrow collapse-arrow-up"></span>See less</a></div></div></div></div><div class="link_block" data-productpage="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html"><div class="link_image"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html" data-width="300"><picture><source srcset="/dam/autochem/applications/hydroformylation-oxo-process/hydroformylation-reaction-300x185.jpg/_jcr_content/renditions/cq5dam.web.240.240.webp" media="(min-width: 0px) and (max-width: 320px)" type="image/webp"><source srcset="/dam/autochem/applications/hydroformylation-oxo-process/hydroformylation-reaction-300x185.jpg/_jcr_content/renditions/cq5dam.web.240.480.jpeg" media="(min-width: 0px) and (max-width: 320px)" type="image/jpeg"><img loading="lazy" src="/dam/autochem/applications/hydroformylation-oxo-process/hydroformylation-reaction-300x185.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" alt="hydroformylation reaction example" title="hydroformylation reaction example"></picture></a></div><div class="link_info"><h3 class="link_title"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html"> Hydroformylation (Oxo Process) </a></h3><div class="link_description familyDescription"><span class="link_description_text"> Hydroformylation, also known as oxo synthesis, is a chemical reaction involving the addition of carbon monoxide (CO) and hydrogen (H₂) to an unsaturated compound, typically an alkene or alkyne. The re... </span><span class='text-collapse-see-more'>...<br></span><a class='text-collapse-link text-collapse-see-more' data-see-more-label="Read more" data-see-less-label="See less"><span class='collapse-arrow collapse-arrow-down'></span><span class="collapse_see_more_lbl"></span></a></div></div><div class="mobile_cta" style="display:none"><div class="familyMobile_bottomRow"><div class="familyMobile_seeDetails"><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html"> See details </a></div><div class="familyMobile_feedbackButtons"><div class="image-feedback"><form class="fb-a-button-wrapper moreinfo_btn familyMobile_requestInfo" method="get" action="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.fb.1.cs.13.html"><button data-href="/content/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.fb.1.cs.13.html" class="fb-button-p5a blue small" data-swiftype-index="false"> Request Info </button></form></div></div><div class="familyMobile_tabNavigation"><ul><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html">Overview</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html#applications">Application Examples</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html#publications">Citations and References</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html#productsolutions">Related Products</a></li><li><a href="/sg/en/home/applications/L1_AutoChem_Applications/L2_ReactionAnalysis/hydroformylation-oxo-process.html#custom5">More Information</a></li></ul></div><div class="familyMobile_seeLess"><a class="text-collapse-link text-collapse-see-less"><span class="collapse-arrow collapse-arrow-up"></span>See less</a></div></div></div></div><div class="link_block"></div></div></div></div><div class="matchingblockpush section"><link rel="stylesheet" href="/etc/designs/mt/widgets/misc/tabnavigation.min-v54.css" type="text/css"><div id="mb_applicationtabsafapplicationspar_3" class="matching_block_wrapper matching_box mb_gridLayout" data-swiftype-index="false"><input type="hidden" name="mbTabItemsCount" value="1"/><div class="tab_navigation_mb title">White Papers</div><div class="center"><div class="content accordion_blue_grey layout_ mb_gridLayout"><div class="mbItemGrid"><div class="mbItemWrapper rowLevel_2"><div class="mbItem"><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/Innovative-Techniques-to-Synthesize-Breakthrough-Molecule.html"><img loading="lazy" src="/dam/direct-upload/smallImage/library/white-papers/automated-reactors/Innovative-Techniques-to-Synthesize-Breakthrough-Molecule/innovative-tech-syn-brk-mole-300x300.png/_jcr_content/renditions/cq5dam.web.1280.1280.png" align="right" alt="Techniques to Synthesize Breakthrough Molecules" title="Techniques to Synthesize Breakthrough Molecules"/></a><div class="itemInfo"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/Innovative-Techniques-to-Synthesize-Breakthrough-Molecule.html"> Techniques to Synthesize Breakthrough Molecules </a></div><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/Innovative-Techniques-to-Synthesize-Breakthrough-Molecule.html"> Advances in organic chemistry allow researchers to expand R&D of molecules and optimize process conditions. 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href="/sg/en/home/library/white-papers/automated-reactors/Modern-Synthesis-Lab.html"> The Modern Synthesis Lab </a></div><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/Modern-Synthesis-Lab.html"> This white paper discusses a new toolbox specifically designed for chemists that expands experimental options, automates tedious tasks and captures hi... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/Modern-Synthesis-Lab.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download White Paper"><span>Download White Paper</span></button></form></div></div></div></div></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/metal-catalyze.html"> Metal Catalyzed Transformations Using In-Situ Spectroscopy </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/metal-catalyze.html"><img loading="lazy" src="/dam/autochem/thank-you-pages/teaser-images/metal-catalyzed-transformations-thumb-300x300.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" align="right" alt="Metal Catalyzed Transformations Using In-Situ Spectroscopy" title="Metal Catalyzed Transformations Using In-Situ Spectroscopy"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/metal-catalyze.html"> This white paper reviews recent advances in organic chemistry using chemical reaction monitoring. </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/metal-catalyze.fb.leftheaderpar.feedbackbinclude.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download White Paper"><span>Download White 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href="/sg/en/home/library/white-papers/automated-reactors/In-Situ-Monitoring-of-Chemical-Reactions-White-Paper.html"> In-situ reaction monitoring using spectroscopy enables scientists to see what is happening in their chemistry while it reacts and allows for immediate... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/In-Situ-Monitoring-of-Chemical-Reactions-White-Paper.fb.leftheaderpar.feedbackbinclude.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download White Paper"><span>Download White Paper</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/Process-FTIR-For-Safe-Operation-of-Sodium-Borohydride-Reduction.html"> Sodium Borohydride Reduction </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/Process-FTIR-For-Safe-Operation-of-Sodium-Borohydride-Reduction.html"><img loading="lazy" src="/dam/non-indexed/po/autochem/whitepapers/process-ftir-safe-operation-sodium-borohydride-reduction/sodium-borohydrideWP--thumb-300x300.png/_jcr_content/renditions/cq5dam.web.1280.1280.png" align="right" alt="sodium borohydride reduction white paper" title="sodium borohydride reduction white paper"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/Process-FTIR-For-Safe-Operation-of-Sodium-Borohydride-Reduction.html"> John O'Reilly of Roche Ireland discusses sustainable Process Analytical Technology (PAT) system using Process FTIR for the safe operation of a sodium... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/Process-FTIR-For-Safe-Operation-of-Sodium-Borohydride-Reduction.fb.lpLeftPar.feedbackbinclude.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download the White Paper"><span>Download the White Paper</span></button></form></div></div></div></div></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/Real-Time-Monitoring-Tandem-Hydroformylation-Hydrogenation.html"> Tandem Hydroformylation/Hydrogenation of Alkenes </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/Real-Time-Monitoring-Tandem-Hydroformylation-Hydrogenation.html"><img loading="lazy" src="/dam/autochem/applications/hydroformylation-oxo-process/tandem-hydroformylation-hydrogenation-300x300.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" align="right" alt="tandem hydroformylation hydrogenation" title="tandem hydroformylation hydrogenation"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/Real-Time-Monitoring-Tandem-Hydroformylation-Hydrogenation.html"> Real time, in-situ mid-FTIR reaction monitoring leads to a greater understanding of catalyst activity and robustness. Researchers at the University of... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/Real-Time-Monitoring-Tandem-Hydroformylation-Hydrogenation.fb.leftheaderpar.feedbackbinclude.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download White Paper"><span>Download White Paper</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/Exothermic-Chemistry-Grignard-Reaction-Scale-Up.html"> Grignard Reaction Scale-up – 4 Steps to Control Development </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/Exothermic-Chemistry-Grignard-Reaction-Scale-Up.html"><img loading="lazy" src="/sg/en/home/library/white-papers/automated-reactors/Exothermic-Chemistry-Grignard-Reaction-Scale-Up/_jcr_content/thumbnailImage.webImage.file.png" align="right" alt="Grignard Reaction Scale-up" title="Grignard Reaction Scale-up"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/Exothermic-Chemistry-Grignard-Reaction-Scale-Up.html"> Exothermic chemical reactions pose inherent risks – especially during scale-up. Published studies from top chemical and pharmaceutical companies show... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/Exothermic-Chemistry-Grignard-Reaction-Scale-Up.fb.mainpar.feedbackbinclude.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Request More Information"><span>Request More Information</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/continuous-reaction-optimization-experiments-rapid-analysis.html"> Rapid Analysis of Continuous Reaction Optimization Experiments </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/continuous-reaction-optimization-experiments-rapid-analysis.html"><img loading="lazy" src="/dam/Newsroom/WhitePapers/Continuous-reaction-optimization-experiments_Thumbnail.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" align="right" alt="Rapid Analysis of Continuous Reaction Optimization Experiments" title="Rapid Analysis of Continuous Reaction Optimization Experiments"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/continuous-reaction-optimization-experiments-rapid-analysis.html"> The white paper - Rapid Analysis of Continuous Reaction Optimization Experiments - discusses how to optimize chemical reactions. </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/continuous-reaction-optimization-experiments-rapid-analysis.fb.leftheaderpar.feedbackbinclude.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download White Paper"><span>Download White Paper</span></button></form></div></div></div></div></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/3-reaction-monitoring-studies.html"> 3 Reaction Monitoring Case Studies </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/3-reaction-monitoring-studies.html"><img loading="lazy" src="/dam/0autochem/reaction-monitoring-case-studies.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" align="right" alt="3 Reaction Monitoring Case Studies" title="3 Reaction Monitoring Case Studies"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/3-reaction-monitoring-studies.html"> In this whitepaper, three case studies carried out at GlaxoSmithKline (GSK) demonstrate how probe-based and real-time FTIR instrumentation helped to c... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/3-reaction-monitoring-studies.fb.leftheaderpar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Get the White Paper Now"><span>Get the White Paper Now</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/Modern-Synthesis-Lab.html"> The Modern Synthesis Lab </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/Modern-Synthesis-Lab.html"><img loading="lazy" src="/dam/autochem/library/whitepaper/modern-synthesis-lab/mod-syn-lab-300x300.png/_jcr_content/renditions/cq5dam.web.1280.1280.png" align="right" alt="The Modern Synthesis Lab" title="The Modern Synthesis Lab"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/Modern-Synthesis-Lab.html"> This white paper discusses a new toolbox specifically designed for chemists that expands experimental options, automates tedious tasks and captures hi... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/Modern-Synthesis-Lab.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download White Paper"><span>Download White Paper</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/chemical-reaction-profiling.html"> Chemical Reaction Profiling: A Review </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/chemical-reaction-profiling.html"><img loading="lazy" src="/dam/0autochem/WP_ReactionProfiling.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" align="right" alt="Chemical Reaction Profiling: A Review" title="Chemical Reaction Profiling: A Review"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/chemical-reaction-profiling.html"> This white paper, In Situ Reaction Profiling: A Literature Review, reviews 20 examples from academic institutions that utilize in situ FTIR Spectrosco... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/white-papers/automated-reactors/chemical-reaction-profiling.fb.leftheaderpar.feedbackb_copy_copy.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Download the Paper Now"><span>Download the Paper Now</span></button></form></div></div></div></div></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/white-papers/automated-reactors/Reaction-Insight-From-Every-Experiment.html"> Reaction Insight from Every Experiment </a></div><div class="image"><a href="/sg/en/home/library/white-papers/automated-reactors/Reaction-Insight-From-Every-Experiment.html"><img loading="lazy" src="/dam/non-indexed/po/autochem/whitepapers/reaction-insights-for-every-experiment/reac-insight-every-reac-300x300.png/_jcr_content/renditions/cq5dam.web.1280.1280.png" align="right" alt="Reaction Insight from Every Experiment" title="Reaction Insight from Every Experiment"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/white-papers/automated-reactors/Reaction-Insight-From-Every-Experiment.html"> This paper presents five examples taken from recent journal articles in which HPLC alone was not sufficient to provide the insight scientists needed.... </a></div><div class="feedback_wrapper"><form method="get" 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action="/sg/en/home/library/on-demand-webinars/automated-reactors/Hydrogenation-and-High-Pressure-Reaction-Monitoring.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="View the Webinar Now"><span>View the Webinar Now</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_2"></div><div class="mbItemWrapper rowLevel_2"><div class="mbItem"><div class="image"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/intensification-process-safety.html"><img loading="lazy" src="/sg/en/home/library/on-demand-webinars/automated-reactors/intensification-process-safety/_jcr_content/thumbnailImage.webImage.file.png" align="right" alt="Impact of Process Intensification on Process Safety" title="Impact of Process Intensification on Process Safety"/></a><div class="itemInfo"><div class="mbItemTitle"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/intensification-process-safety.html"> Impact of Process Intensification on Process Safety </a></div><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/on-demand-webinars/automated-reactors/intensification-process-safety.html"> This presentation discusses how Nalas Engineering safely handles high energy materials and hazardous chemistry. </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/on-demand-webinars/automated-reactors/intensification-process-safety.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="View the Presentation Now"><span>View the Presentation Now</span></button></form></div></div></div></div></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/Rationalizing-Unusual-Kinetics-in-C-H-Activations.html"> Rationalizing Unusual Kinetics in C-H Activations </a></div><div class="image"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/Rationalizing-Unusual-Kinetics-in-C-H-Activations.html"><img loading="lazy" src="/sg/en/home/library/on-demand-webinars/automated-reactors/Rationalizing-Unusual-Kinetics-in-C-H-Activations/_jcr_content/thumbnailImage.webImage.file.png" align="right" alt="Reaction Kinetics Progress Analysis Ryan Baxter" title="Reaction Kinetics Progress Analysis Ryan Baxter"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/on-demand-webinars/automated-reactors/Rationalizing-Unusual-Kinetics-in-C-H-Activations.html"> This webinar explores a graphical analysis approach to rationalize unusual kinetics in C-H activations. The Reaction Progress Kinetic Analysis (RPKA)... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/on-demand-webinars/automated-reactors/Rationalizing-Unusual-Kinetics-in-C-H-Activations.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="View the Webinar Now"><span>View the Webinar Now</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/Hydrogenation-and-High-Pressure-Reaction-Monitoring.html"> Hydrogenation and High Pressure Reaction Monitoring </a></div><div class="image"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/Hydrogenation-and-High-Pressure-Reaction-Monitoring.html"><img loading="lazy" src="/sg/en/home/library/on-demand-webinars/automated-reactors/Hydrogenation-and-High-Pressure-Reaction-Monitoring/_jcr_content/thumbnailImage.webImage.file.png" align="right" alt="Hydrogenation Under High Pressure" title="Hydrogenation Under High Pressure"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/on-demand-webinars/automated-reactors/Hydrogenation-and-High-Pressure-Reaction-Monitoring.html"> This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/on-demand-webinars/automated-reactors/Hydrogenation-and-High-Pressure-Reaction-Monitoring.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="View the Webinar Now"><span>View the Webinar Now</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/lonza.html"> DoE to Peptide Synthesis </a></div><div class="image"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/lonza.html"><img loading="lazy" src="/sg/en/home/library/on-demand-webinars/automated-reactors/lonza/_jcr_content/thumbnailImage.webImage.file.png" align="right" alt="DoE to Peptide Synthesis" title="DoE to Peptide Synthesis"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/on-demand-webinars/automated-reactors/lonza.html"> Learn how Design of Experiments (DoE) is applied to chemical synthesis at Lonza Peptide. </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/on-demand-webinars/automated-reactors/lonza.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="Watch Free Webinar"><span>Watch Free Webinar</span></button></form></div></div></div></div></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/new-radical-reactions-enabled-by-in-situ-reaction-monitoring.html"> New Radical Reactions Enabled by In Situ Reaction Monitoring </a></div><div class="image"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/new-radical-reactions-enabled-by-in-situ-reaction-monitoring.html"><img loading="lazy" src="/dam/0autochem/BaxterJan23_webinar_thumb_.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" align="right" alt="New Radical Reactions Enabled by In Situ Reaction Monitoring" title="New Radical Reactions Enabled by In Situ Reaction Monitoring"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/on-demand-webinars/automated-reactors/new-radical-reactions-enabled-by-in-situ-reaction-monitoring.html"> Presented by Professor Ryan Baxter of the University of California-Merced, this on-demand webinar discusses research that involved new radical reactio... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/on-demand-webinars/automated-reactors/new-radical-reactions-enabled-by-in-situ-reaction-monitoring.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="View the Presentation Now"><span>View the Presentation Now</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/process-development-and-kinetic-understanding.html"> Process Development and Kinetic Understanding </a></div><div class="image"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/process-development-and-kinetic-understanding.html"><img loading="lazy" src="/dam/0autochem/Moschetta_thumb_.jpg/_jcr_content/renditions/cq5dam.web.1280.1280.jpeg" align="right" alt="Process Development and Kinetic Understanding" title="Process Development and Kinetic Understanding"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/on-demand-webinars/automated-reactors/process-development-and-kinetic-understanding.html"> Presented by Eric Moschetta, this on-demand webinar describes how AbbVie built a robust kinetic model to understand a late-stage API process </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/on-demand-webinars/automated-reactors/process-development-and-kinetic-understanding.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="View the Presentation Now"><span>View the Presentation Now</span></button></form></div></div></div></div></div><div class="mbVerticalSeparator rowLevel_3"></div><div class="mbItemWrapper rowLevel_3"><div class="mbItem"><div class="mbItemTitle"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/Development-of-an-Alkylation-Reaction.html"> Development of an Alkylation Reaction </a></div><div class="image"><a href="/sg/en/home/library/on-demand-webinars/automated-reactors/Development-of-an-Alkylation-Reaction.html"><img loading="lazy" src="/sg/en/home/library/on-demand-webinars/automated-reactors/Development-of-an-Alkylation-Reaction/_jcr_content/thumbnailImage.webImage.file.png" align="right" alt="Alkylation Reaction Development" title="Alkylation Reaction Development"/></a><div class="itemInfo"><div class="description hyphenate"><a class="noStyle" href="/sg/en/home/library/on-demand-webinars/automated-reactors/Development-of-an-Alkylation-Reaction.html"> Kevin Stone discusses how Merck Chemical Engineering Research & Development (CERD) leverages process fingerprinting tools in the development of an Alk... </a></div><div class="feedback_wrapper"><form method="get" action="/sg/en/home/library/on-demand-webinars/automated-reactors/Development-of-an-Alkylation-Reaction.fb.lpLeftPar.feedbackb.html"><button class="fb-button-p5a btn-action btn-primary" aria-label="View the Webinar Now"><span>View the Webinar Now</span></button></form></div></div></div></div></div></div></div></div></div><div class="mbSeparator"></div></div></div></div></div></div><div class="ptab-content publications" data-tab-name="publications" id="publications"><h3 class="ptabs_accordion_header simple-accordion_header simple-accordion_header-large"><span class="accordion_expander simple-accordion_icon"></span>Publications</h3><div class="ptab-content-body"><h3>Publications on Synthetic Organic Chemistry</h3><div class="mask"></div><div class="publicationsblockpar parsys"><div 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.responsive-content-text-links,#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .responsive-content-image,#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .responsive-content-video{position:relative;float:none;clear:both;width:auto;box-sizing:border-box;margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .responsive-content-text-links{margin-top:15px;margin-bottom:15px;margin-right:15px;margin-left:15px}#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .responsive-content-text-wrap{text-align:initial}#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .responsive-content-image{text-align:center;margin-top:15px;margin-right:0;margin-left:0;margin-bottom:15px}#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .text-light .responsive-content-title,#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .text-light .responsive-content-text-wrap p{color:#666}#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .responsive-content-title{margin-top:0}#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .repsponsive-content-link-wrap .simplelinklist a.white-link,#responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e .repsponsive-content-link-wrap .simplelinklist a.white-link:hover{color:#004494;text-decoration:none}}</style><div class="responsive-content-wrapper subtle image-top" id="responsive-content-wrapper-8be7f633-ca54-49c1-9ab1-92b8c41a025e" style="min-height:0px;"><div class="responsive-content-text-links "><div class="responsive-content-text-wrap"><h2 class="responsive-content-title">Chemical Synthesis in Peer-Reviewed Publications</h2><div class="text"><ul><li>Si-min Yu, William K. Snavely, Raghunath V. Chaudhari, Bala Subramaniam, “Butadiene hydroformylation to adipaldehyde with Rh-based catalysts: Insights into ligand effects”, Mol.Catal., 2020, 484, 110721.</li><li>Ryan Nouch, Simon Woodward, Darren Willcox, David Robinson, William Lewis, "Mechanistic-Insight-Driven Rate Enhancement of Asymmetric Copper-Catalyzed 1,4-Addition of Dialkylzinc Reagents to Enones”, Organometallics 2020, March 3, 2020, https://doi.org/10.1021/acs.organomet.0c00005.</li><li>Reni Grauke, Rahel Schepper, Jabor Rabeah , Roland Schoch, Ursula Bentrup, Matthias Bauer, Angelika Brückner, “Impact of Al Activators on Structure and Catalytic Performance of Cr Catalysts in Homogeneous Ethylene Oligomerization – A Multitechnique in situ/operando Study”, 23 October 2019, https://doi.org/10.1002/cctc.201901441.</li><li>Drew M. Hood, Ryan A. Johnson, Alex E. Carpenter, Jarod M. Younker, David J. Vinyard, George G. Stanley, “Highly active cationic cobalt(II) hydroformylation catalysts”, Science, 2020, 367(6477), 542-548.</li><li>Anne-Marie Dechert-Schmitt, Michelle R. Garnsey, Hanna M. Wisniewska, James I. Murray, Taegyo Lee, Daniel W. Kung, Neal Sach, and Donna G. Blackmond, “Highly Modular Synthesis of 1,2-Diketones via Multicomponent Coupling Reactions of Isocyanides as CO Equivalents”, ACS Catal. 2019, 9, 4508−4515.</li><li>Michaela Wernik, Peter Poechlauer, Christoph Schmoelzer, Doris Dallinger, C. Oliver Kappe, “Design and Optimization of a Continuous Stirred Tank Reactor Cascade for Membrane-Based Diazomethane Production: Synthesis of α‑Chloroketones”, Org. Process Res. Dev. 2019, 23, 1359−1368.</li><li>Kori A. Andrea, Francesca M. Kerton, “Triarylborane-Catalyzed Formation of Cyclic Organic Carbonates and Polycarbonates”, ACS Catal., 2019, 9, pp 1799–1809.</li><li>Thibault E. Schmid, Carine Robert, Vincent Richard, Sumesh K. Raman, Vincent Guérineau, Christophe M. Thomas, “Aluminum‐Catalyzed One‐Pot Synthesis of Polyester‐b‐Polypeptide Block Copolymers by Ring‐Opening Polymerization”, Macromol. Chem. and Phys., 2019, <u><a href="https://onlinelibrary.wiley.com/toc/15213935/2019/220/14" _rte_href="https://onlinelibrary.wiley.com/toc/15213935/2019/220/14">220(14</a></u>), https://doi.org/10.1002/macp.201900040.</li><li>Niklas O. Thiel, Benyapa Kaewmee, Trung Tran Ngoc, Johannes F. Teichert, “A Simple Nickel Catalyst Enables Broad E-Selective Alkyne Semihydrogenation”, ChemRxiv, 23/08/2019 doi.org/10.26434/chemrxiv.9715955.v1.</li><li>Jeanne Masson-Makdissi, Young Jin Jang, Liher Prieto, Mark S. Taylor, Mark Lautens, “Rhodium-Catalyzed Tandem Isomerization−Allylation: From Diallyl Carbonates to α‑Quaternary Aldehydes”, ACS Catal. 2019, 9, 11808−11812.</li></ul></div></div></div></div></div></div></div></div><div class="ptab-content productsolutions" data-tab-name="productsolutions" id="productsolutions"><h3 class="ptabs_accordion_header simple-accordion_header simple-accordion_header-large"><span class="accordion_expander simple-accordion_icon"></span>Related Products</h3><div class="ptab-content-body"><h3>Synthetic Organic Chemistry Tools</h3><div class="mask"></div><div id="ptab_products_data"><div class="afproductspar parsys"><div class="linklist section"><script src="/etc/designs/mt/widgets/misc/linklist.min-v54.js"></script> <div class="main_content_layer linklist_main_content_layer"><div class="link_blocks"><div class="link_block"><div class="link_image"><a href="/sg/en/home/products/L1_AutochemProducts/automated-sampling-systems.html"><img loading="lazy" 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