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<!doctype html> <html lang="te"> <head> <title>Molecular-Mediated Difference Action of Poloxham124/188: Abs | 98568</title> <meta name="keywords" content="Xiaoying Lin, Xinxin Zhou, Feng Hao, Lele Li, Yue Cui, Yanfei Zhang, Jiao Guan, Heyun Zhu, Bo Feng, "/> <meta name="description" content="Poloxamers (PLs) are commonly used pharmaceutical excipients. According to the different molecular weight, mainly PL124 and PL188 are observed. PL188 with ..98568"/> <meta name="citation_publisher" content="లాంగ్‌డమ్ పబ్లిషింగ్ SL" /> <meta name="citation_journal_title" content="జర్నల్ ఆఫ్ డ్రగ్ మెటబాలిజం & టాక్సికాలజీ"> <meta name="citation_title" content="Molecular-Mediated Difference Action of Poloxham124/188: Absorption, Efflux and Suborganelle Accumulation in Caco-2 Cells"> <meta name="citation_author" content="Xiaoying Lin" /> <meta name="citation_author" content="Xinxin Zhou" /> <meta name="citation_author" content="Feng Hao" /> <meta name="citation_author" content="Lele Li" /> <meta name="citation_author" content="Yue Cui" /> <meta name="citation_author" content="Yanfei Zhang" /> <meta name="citation_author" content="Jiao Guan" /> <meta name="citation_author" content="Heyun Zhu" /> <meta name="citation_author" content="Bo Feng" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="14"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Poloxamers (PLs) are commonly used pharmaceutical excipients. According to the different molecular weight, mainly PL124 and PL188 are observed. PL188 with the larger weight, hydrophilic and more application in oral exposure drug delivery systems than PL124. However, the absorption and transport mechanisms of PL188 into intestinal epithelial cells are still unclear. In this study, we study the uptake and efflux of PL124/188 in Caco-2 cells, and subcellular accumulation in Caco-2 cells quantitatived by ultra-high-performance liquid chromatography-triple/time-of-flight mass spectrometry (UHPLC-Q-TOF/MS). The results showed that, the uptake in Caco-2 cells are different: Both PL188 and 124 entered Caco-2 cells through active transport, but PL188 uptake into Caco-2 cells relies on pinocytosis pathway, fosselin-mediated endocytosis pathway, and the endocytosis pathway independent of mestin and fosselin-mediated endocytosis. While PL124 uptake by independent of clathrin- and fossa-mediated endocytosis inhibitors pathway; The effects of PL188 on P-gp protein substrate were different: PL188 was stronger than PL124; There are also differences in subcellular accumulations: PL124 reaches the cell membrane at a slower rate compared to PL188, which rapidly enters the cytoplasm and nucleus, with a higher concentration in the cytoplasm. Both PL124 and PL188 remain in the skeleton. This work provides data basis for our subsequent application of PL188 and PL124 as oral preparations. 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According to the different molecular weight, mainly PL124 and PL188 are observed. PL188 with the larger weight, hydrophilic and more application in oral exposure drug delivery systems than PL124. However, the absorption and transport mechanisms of PL188 into intestinal epithelial cells are still unclear. In this study, we study the uptake and efflux of PL124/188 in Caco-2 cells, and subcellular accumulation in Caco-2 cells quantitatived by ultra-high-performance liquid chromatography-triple/time-of-flight mass spectrometry (UHPLC-Q-TOF/MS). The results showed that, the uptake in Caco-2 cells are different: Both PL188 and 124 entered Caco-2 cells through active transport, but PL188 uptake into Caco-2 cells relies on pinocytosis pathway, fosselin-mediated endocytosis pathway, and the endocytosis pathway independent of mestin and fosselin-mediated endocytosis. While PL124 uptake by independent of clathrin- and fossa-mediated endocytosis inhibitors pathway; The effects of PL188 on P-gp protein substrate were different: PL188 was stronger than PL124; There are also differences in subcellular accumulations: PL124 reaches the cell membrane at a slower rate compared to PL188, which rapidly enters the cytoplasm and nucleus, with a higher concentration in the cytoplasm. Both PL124 and PL188 remain in the skeleton. This work provides data basis for our subsequent application of PL188 and PL124 as oral preparations.</p> <div class="alert alert-info text-left"><b>నిరాకరణ:</b> ఈ సారాంశం కృత్రిమ మేధస్సు సాధనాలను ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా ధృవీకరించబడలేదు.</div> <div class="nav social-icons"> <a class="nav-link w-auto">ఈ కథనాన్ని భాగస్వామ్యం చేయండి</a> <a title="ఇక్కడ నొక్కండి" target="_blank" href="https://www.facebook.com/sharer.php?u=https://telugu.longdom.org/abstract/molecularmediated-difference-action-of-poloxham124188-absorption-efflux-and-suborganelle-accumulation-in-caco2-cells-98568.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="ఇక్కడ నొక్కండి" target="_blank" href="https://twitter.com/share?url=https://telugu.longdom.org/abstract/molecularmediated-difference-action-of-poloxham124188-absorption-efflux-and-suborganelle-accumulation-in-caco2-cells-98568.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="ఇక్కడ నొక్కండి" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://telugu.longdom.org/abstract/molecularmediated-difference-action-of-poloxham124188-absorption-efflux-and-suborganelle-accumulation-in-caco2-cells-98568.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="ఇక్కడ నొక్కండి" target="_blank" href="https://plus.google.com/share?url=https://telugu.longdom.org/abstract/molecularmediated-difference-action-of-poloxham124188-absorption-efflux-and-suborganelle-accumulation-in-caco2-cells-98568.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">కంటెంట్ లింక్‌లు</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://telugu.longdom.org/privacy-policy.html" title="ఇక్కడ నొక్కండి">గోప్యతా విధానం</a></li> <li><a class="" href="https://telugu.longdom.org/terms-conditions.html" title="ఇక్కడ నొక్కండి">నిబంధనలు & షరతులు</a></li> <li><a class="" href="https://telugu.longdom.org/authors-reviewers-editors.html" title="ఇక్కడ నొక్కండి">రచయితలు, సమీక్షకులు & ఎడిటో</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">లాంగ్‌డమ్‌ను సంప్రదించండి</h4> <p><strong>లాంగ్‌డమ్ గ్రూప్ SA</strong><br /> అవెన్యూ రోజర్ వాండెండ్రీస్చే,<br /> 18, 1150 బ్రస్సెల్స్, బెల్జియం<br /> ఫోన్: +442038085340<br /> <strong>ఇమెయిల్:</strong> <a class="white" href="mailto:info@longdom.org" title="Click here">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">కనెక్ట్ చేయండి</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="ఇక్కడ నొక్కండి" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="ఇక్కడ నొక్కండి" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="ఇక్కడ నొక్కండి" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="ఇక్కడ నొక్కండి" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>కాపీరైట్ © 2024 <a href="https://telugu.longdom.org/" title="ఇక్కడ నొక్కండి" class="white">లాంగ్‌డమ్ పబ్లిషింగ్ SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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