Studierende forschen an Gentherapie für Mukoviszidose

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aria-controls="offcanvas-navi"> <i class="fas fa-bars"></i> <span lang="en" class="sr-only">Toggle Menu</span> </button> </div> </div> </nav> </div> </header> <div class="my-5"></div> <div id="content" class="site-content container" data-id="79051"> <div id="primary" class="content-area"> <div class="row"> <div class="backToOverview my-3"> <a href="/?lang=de" target="_SELF">« Zurück zur Übersicht</a> </div> <div class="col-12"> <nav class="breadcrumb mb-4 mt-2 py-2 px-3 justify-content-center small rounded"><a href="https://aktuell.uni-bielefeld.de/category/forschung/" rel="category tag">Forschung</a> <span class="divider"> / </span> <a href="https://aktuell.uni-bielefeld.de/category/news/" rel="category tag">News</a></nav> </div> </div> <div class="col-md-12"> <main id="main" class="site-main userGeneratedContent"> <header class="entry-header"> <h1> Studierende forschen an Gentherapie für Mukoviszidose </h1> <p class="text-center"> <small class="text-muted"> <span class="posted-on"><span rel="bookmark"><time class="entry-date published updated" datetime="2024-10-15T16:19:13+02:00">15. Oktober 2024</time></span></span> <br/>Autor*in: Isabell Alexandra Guckes, iGEM-Team Bielefeld </small> </p> </header> <div class="entry-content"> <p><strong>Ein interdisziplinäres studentisches Forschungsteam der Universität Bielefeld verbessert eine Gentherapie zur Behandlung von Mukoviszidose, eine der weltweit häufigsten genetischen Erkrankungen. Mit ihrem Projekt nehmen die Studierenden am iGEM-Wettbewerb, dem größten internationalen Wettbewerb der synthetischen Biologie, teil. Vom 23. bis 26. Oktober stellen sie ihre Forschungsergebnisse auf dem Grand Jamboree in Paris vor und konkurrieren dort mit über 450 Teams aus aller Welt.</strong></p> <div class="wp-block-cgb-block-unidivider uni-divider"></div> <p>Das <a href="https://2024.igem.wiki/bielefeld-cebitec/igem-bielefeld">diesjährige Team „PreCyse“</a> der Universität Bielefeld beschäftigt sich mit der Erbkrankheit Mukoviszidose. Die Erbkrankheit wird durch Mutationen im Gen für den CFTR-Ionenkanal verursacht. Das ist ein Protein, das das Innere und Äußere der Zelle verbindet. Ziel der Bielefelder Studierenden ist es, eine Gentherapie für die am häufigsten vorkommende Mutation des CRTR-Kanals weiterzuentwickeln, um sie effizient zu korrigieren.</p> <p>Das Forschungsteam setzt auf „Prime Editing“, was präzise Genveränderungen ermöglicht, und somit das Gen für den Ionenkanal repariert. Die Gentherapie wird direkt in die Lunge verabreicht, um die Atemwege gezielt zu behandeln. Die neue Behandlungsmethode könnte zukünftig das Leben von Patient*innen verbessern, indem sie nicht nur die Symptome lindert, sondern die Ursache der Krankheit bekämpft.</p> <div class="wp-block-cgb-block-uniimage uni-image col-md-8 offset-md-2"><div class="content"></div><div class="image"><div><img decoding="async" class="gallery-item" alt="Gruppenbild der 13 Team-Mitgliedern" src="https://aktuell.uni-bielefeld.de/wp-content/uploads/2024/10/iGem_aktuellBild-1024x576.jpg" /><p class="copyright">© Universität Bielefeld/Team Medienpraxis</p><div class="slide-content "><div class="caption-title"></div><div class="caption-text">Die interdisziplinare Gruppe aus 13 Studierenden präsentiert ihre Forschung in Paris.</div></div></div></div></div> <p>Neben ihrer Forschungsarbeit engagiert sich das Team auch außerhalb des Labors. Die Studierenden führen zahlreiche Gespräche mit Betroffenen, Ärzten und Wissenschaftler*innen, um ihr Projekt mit praktischen Erkenntnissen zu bereichern. Darüber hinaus organisieren sie Veranstaltungen wie das erste BFH European Meetup in Bielefeld, ein Treffen für europäische iGEM-Teams, um den Austausch zwischen ihnen zu fördern.</p> <p>Die Teilnahme am iGEM-Wettbewerb bietet den Studierenden die Möglichkeit, ihre Fähigkeiten in verschiedenen Disziplinen weiterzuentwickeln, sei es in der Labortechnik, im Design von Websites oder in der Öffentlichkeitsarbeit. Mit einem interdisziplinären Ansatz vereinen sie Kompetenzen unter anderen aus den Bereichen Biologie und Medienwissenschaften, um ihr Projekt erfolgreich zu präsentieren. Die Studierenden hoffen, dass ihre Forschung langfristig dazu beitragen kann, Gentherapien sicherer und effektiver zu machen.</p> <div class="wp-block-cgb-block-uniicon uni-icon"><h2 class="title">iGEM: interdisziplinäre Projektarbeit</h2><div class="uni-factbox d-flex"><div class="uni-factbox__Container--icon d-flex"><img decoding="async" src="/wp-content/plugins/wp-unibi-plugins-2021/assets/icons/FaktenBox_Hintergrund.svg" class="uni-factbox__icon" aria-hidden="true" /></div><div class="uni-factbox__Container--text"> <p>Der „<a href="https://competition.igem.org/" data-type="link" data-id="https://competition.igem.org/">international Genetically Engineered Machine“-Wettbewerb</a> bietet seit 2004 jährlich Studierenden die Möglichkeit, ihr eigenes Projekt im Bereich der synthetischen Biologie zu verwirklichen. Der Wettbewerb legt dabei nicht nur ein Augenmerk auf die Laborarbeit, sondern setzt einen starken Impuls die möglichen soziologischen, ökonomischen und sicherheitsrelevanten Aspekte der eigenen Projektidee zu reflektieren.</p> </div></div></div> <p></p> </div> <div class="row"> <div class="backToOverview my-3"> <a href="/?lang=de" target="_SELF">« Zurück zur Übersicht</a> </div> </div> <div class="entry-footer clear-both"> <script> //jQuery for the slick similar post slider jQuery(document).ready(function($) { $(".similar-posts-slider").not('.slick-initialized').slick({ slidesToShow: 4, slidesToScroll: 4, responsive: [{ breakpoint: 1400, centerMode: true, centerPadding: '60px', settings: { slidesToShow: 3, slidesToScroll: 3, } }, { breakpoint: 1000, settings: { slidesToShow: 2, slidesToScroll: 2 } }, { breakpoint: 770, settings: { slidesToShow: 1, slidesToScroll: 1 } } ] }); }); </script> <div class="mt-4 mb-4"> <h2> Ähnliche Beiträge </h2> <div class="similar-posts-slider similarPostsSlider"> <div class="post similarPostsSlider__item "> <a href="https://aktuell.uni-bielefeld.de/2024/11/05/vierfach-gold-fuer-bielefelder-igem-team/" target="_SELF" data-id="79993"> <div class="card-img similarPostsSlider__img"> <img src="https://aktuell.uni-bielefeld.de/wp-content/uploads/2024/11/2024-11-05-iGEM_Team_mit_Preisen_quad-400x400.jpg" loading="lazy" alt="Gruppenbild der 13 Studierenden mit ihren iGEM-Preisen." class="attachment-thumbnail_square size-thumbnail_square wp-post-image" /> </div> <div class="similarPostsSlider__imgCopyright"> <small> © iGEM Foundation</small> </div> <div class="similarPostsSlider__title"> Vierfach Gold für Bielefelder iGEM-Team </div> <a class="read-more sr-only" href="https://aktuell.uni-bielefeld.de/2024/11/05/vierfach-gold-fuer-bielefelder-igem-team/">Weiterlesen » <span> zu Vierfach Gold für Bielefelder iGEM-Team</span></a> </a> </div> <div class="post similarPostsSlider__item "> <a href="https://aktuell.uni-bielefeld.de/2024/10/30/mikroalgen-fuer-nachhaltige-treibstoffe/" target="_SELF" data-id="79769"> <div class="card-img similarPostsSlider__img"> <img src="https://aktuell.uni-bielefeld.de/wp-content/uploads/2024/10/2019-07-08_Olaf-Kruse-4002-1-400x400.jpeg" loading="lazy" alt="Bild der Person Olaf Kruse" class="attachment-thumbnail_square size-thumbnail_square wp-post-image" /> </div> <div class="similarPostsSlider__imgCopyright"> <small> © Universität Bielefeld/ S. 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