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class="content-sidebar-wrap"><main class="content"><article class="post-1735 post type-post status-publish format-standard has-post-thumbnail category-connect-to-science category-general category-innovation category-product-news category-sustainability tag-immunoprecipitation tag-innovation tag-magnetic-beads tag-sustainability entry" aria-label="The Future of Magnetic Beads is Plastic-Free"><header class="entry-header"><h1 class="entry-title">The Future of Magnetic Beads is Plastic-Free</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/danadamico/" title="Posts by Dana D'Amico" rel="author">Dana D'Amico</a> </span> <span class="post-info-date"> 02.06.2023 </span> </header><div class="entry-content"><div id="attachment_1739" style="width: 960px" class="wp-caption aligncenter"><img decoding="async" aria-describedby="caption-attachment-1739" class="wp-image-1739" src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Cloudberry-Hero-1024x768.jpg" alt="The Thermo Fisher Scientific R&D team helped develop DynaGreen magnetic beads with sustainability in mind. " width="950" height="713" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Cloudberry-Hero-1024x768.jpg 1024w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Cloudberry-Hero-300x225.jpg 300w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Cloudberry-Hero-768x576.jpg 768w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Cloudberry-Hero-1536x1152.jpg 1536w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Cloudberry-Hero.jpg 2000w" sizes="(max-width: 950px) 100vw, 950px" /><p id="caption-attachment-1739" class="wp-caption-text">Norway-based Thermo Fisher Scientific R&D scientists Maren Johansen (left), Daniel Firth (center), and Jan Paulsen (right) are part of the team that helped develop DynaGreen magnetic beads.</p></div> <h1>Sustainable science with magnetic beads:</h1> <h2>How more than 30 years of continuous innovation have brought magnetic beads beyond the micron, beyond plastic, and into a more sustainable future with DynaGreen</h2> <h2></h2> <p><i><span data-contrast="auto">“Why go to space when you can go to Trondheim?”<sup>1</sup> </span></i><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Newsweek magazine </span><a href="https://www.sintef.no/en/sintef-group/timeline/1978-tiny-spheres-to-treat-cancer-and-much-more/"><span data-contrast="none">posed this question</span></a><span data-contrast="auto"> to its readers nearly forty years ago after a visit to the lab of Norwegian Institute of Technology professor John Ugelstad.</span><span data-contrast="auto"> In 1976, Ugelstad had accomplished what NASA scientists had all but ruled out. He’d managed to create perfect, microscopic plastic spheres without leaving Earth, in spite of gravity.<sup>2</sup></span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">By the 1980s, his innovation had led to a </span><a href="https://www.thermofisher.com/us/en/home/brands/product-brand/dynal/the-history-of-dynabeads.html?icid=bid_cbu_sbu_r01_co_cp1450_pjt9002_blg40689_0so_blg_il_awa_og_s00_Blog_DynaGreen"><span data-contrast="none">magnetic version of these plastic beads</span></a><span data-contrast="auto"> – a technology that revolutionized the medical and life science research fields by allowing the precise separation, isolation and manipulation of biological samples. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <div id="attachment_1743" style="width: 310px" class="wp-caption alignright"><img decoding="async" aria-describedby="caption-attachment-1743" class="wp-image-1743 size-medium" src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/004-SINTEF-Ugelstad-300x280.jpg" alt="Norwegian chemist John Ugelstad, inventor of magnetic bead technology " width="300" height="280" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/004-SINTEF-Ugelstad-300x280.jpg 300w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/004-SINTEF-Ugelstad.jpg 418w" sizes="(max-width: 300px) 100vw, 300px" /><p id="caption-attachment-1743" class="wp-caption-text">Norwegian chemist John Ugelstad, inventor of magnetic bead technology</p></div> <p><span data-contrast="auto">Today’s </span><a href="https://www.thermofisher.com/us/en/home/brands/product-brand/dynal.html?icid=bid_cbu_sbu_r01_co_cp1450_pjt9002_blg40689_0so_blg_il_awa_og_s00_Blog_DynaGreen"><span data-contrast="none">Dynabeads</span></a><span data-contrast="auto">® magnetic beads are the direct descendants of those first commercial magnetic beads created with Ugelstad’s method. They are a mainstay across all fields of life science and a key enabler of cutting-edge research from </span><a href="https://www.outsourcing-pharma.com/Article/2017/10/03/The-tech-behind-the-first-FDA-approved-CAR-T-cell-therapy"><span data-contrast="none">CAR-T cell cancer immunotherapy</span></a><span data-contrast="auto"> to </span><a href="https://www.thermofisher.com/blog/life-in-the-lab/how-to-automate-your-sars-cov-2-wastewater-testing-workflows-4-key-questions/?cid=bid_cbu_sbu_r01_co_cp1450_pjt9002_blg40689_0so_blg_il_awa_og_s00_Blog_DynaGreen"><span data-contrast="none">epidemiological wastewater surveillance</span></a><span data-contrast="auto">. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Ugelstad’s legacy also lives on at the Thermo Fisher Scientific sites in Oslo and Lillestrøm, Norway that produce Dynabeads and other magnetic bead technologies. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“I always think about [Ugelstad and magnetic beads] as almost like a Norwegian fairy tale,” said Oslo-based Thermo Fisher product manager Claire Mount Lund. “I think everyone that works here at the Norway sites feels pride and passion in what they do because of that legacy. We really feel like we live and breathe our mission because of these beads and their huge impact in academia, diagnostics and beyond.”</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h2>A modern era of sustainable lab practices and products</h2> <p><span data-contrast="auto">Though the commitment to bold innovation has carried through the decades, the conversation around plastic has changed significantly since Ugelstad’s time. Sustainable labs around the world are seeking more ways to reduce energy consumption and waste created by laboratories, while maintaining the quality or output required for their research. Now, a new generation of scientists at Thermo Fisher Scientific in Norway is tackling a different type of polymer challenge – how to skip the plastic altogether. They join </span><span data-contrast="auto">the rest of the world in asking, </span><i><span data-contrast="auto">how can we live and work more sustainably?</span></i><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"><br /> </span></p> <p><span data-contrast="auto">What they’ve come up with is a pioneering plastic-free technology in the </span><a href="https://www.thermofisher.com/us/en/home/life-science/protein-biology/protein-assays-analysis/immunoprecipitation/dynagreen-magnetic-beads.html?cid=bid_cbu_sbu_r01_co_cp1450_pjt9002_blg40689_0so_blg_il_awa_og_s00_Blog_DynaGreen"><span data-contrast="none">Invitrogen™ DynaGreen™ magnetic beads platform</span></a><span data-contrast="auto">. DynaGreen launched at the start of 2023 with several immunoprecipitation options but is poised to expand to many more applications over the next few years – promising researchers a more affordable and eco-conscious tool at the bench. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h2>Magnetic separation used for immunoprecipitation</h2> <p><span data-contrast="auto">In the past few decades, </span><a href="https://www.youtube.com/watch?v=lMsH0jiKscw"><span data-contrast="none">publication trends have made</span></a> <span data-contrast="none">clear</span><span data-contrast="auto"> that more researchers are catching on to the value of magnetic beads in immunoprecipitation (IP). </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Precoated with proteins or antibodies, magnetic beads bind quickly to the IP target in solution. With a few wash steps and elution as needed, scientists can achieve consistent results with little to no background or sample loss. The process can even be automated for the ultimate hands-off process.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><iframe loading="lazy" title="Immunoprecipitation On Bench Paper - A Surprising Shift" width="760" height="428" src="https://www.youtube.com/embed/lMsH0jiKscw?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></p> <p><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span><span data-contrast="auto">For many scientists, the switch from agarose or Sepharose columns in IP to magnetic beads — whether manual or automated — is a game-changer. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“There is an option to use agarose beads. But many of the researchers we talked to say, once you try magnetic, there’s no going back,” said Lund. “It’s just so much easier to use and more reliable than using agarose columns.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Many magnetic beads have come onto the market since the days of Ugelstad, but Dynabeads has historically led the literature in citations. DynaGreen now benefits from the more than 30 years of legacy experience built upon the science of Dynabeads. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">With its new launch, DynaGreen is available in a few standard variations: DynaGreen Protein A , DynaGreen Protein A/G, and DynaGreen Capture Select ™ Anti-IgG-Fc. With these three options, researchers have a route to capturing almost any IP target. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">For the first time, they’ll also now have a route to capturing their targets with a more sustainably designed bead. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p> </p> <h2>Sustainable design from start to finish</h2> <h3>The green chemistry behind product development</h3> <p><span data-contrast="auto">The field of “green chemistry” emerged not so long ago in the </span><a href="https://www.acs.org/content/acs/en/greenchemistry/what-is-green-chemistry/history-of-green-chemistry.html"><span data-contrast="auto">late 1990s</span></a><span data-contrast="auto"> and accelerated quickly. Chemist-entrepreneurs Paul Anastas and John Warner famously developed the </span><a href="https://www.acs.org/content/acs/en/greenchemistry/principles/12-principles-of-green-chemistry.html"><span data-contrast="none">12 Principles of Green Chemistry</span></a><span data-contrast="auto"> in 1998 as a framework for minimizing the environmental impact of chemical products and processes.</span><span data-contrast="auto"><sup>3</sup></span><span data-contrast="auto"> </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">The 12 Principles lists a dozen guidelines that span the entire life cycle of a chemical product, from efficient use of materials in design to end-of-function planning and accident prevention. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Most of all, the 12 Principles framework encourages a holistic approach to sustainable innovation. In the case of DynaGreen, it meant innovating far beyond the scope of removing microplastic from the bead’s core. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <div id="attachment_1752" style="width: 1810px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-1752" class="wp-image-1752 size-full" src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/001-12-Principles-Infographic-Created-by-D.-DAmico-no-license-needed-1.png" alt="Chemist-entrepreneurs Paul Anastas and John Warner famously developed the 12 Principles of Green Chemistry in 1998 as a framework for minimizing the environmental impact of chemical products and processes" width="1800" height="840" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/001-12-Principles-Infographic-Created-by-D.-DAmico-no-license-needed-1.png 1800w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/001-12-Principles-Infographic-Created-by-D.-DAmico-no-license-needed-1-300x140.png 300w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/001-12-Principles-Infographic-Created-by-D.-DAmico-no-license-needed-1-1024x478.png 1024w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/001-12-Principles-Infographic-Created-by-D.-DAmico-no-license-needed-1-768x358.png 768w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/001-12-Principles-Infographic-Created-by-D.-DAmico-no-license-needed-1-1536x717.png 1536w" sizes="(max-width: 1800px) 100vw, 1800px" /><p id="caption-attachment-1752" class="wp-caption-text">Chemist-entrepreneurs Paul Anastas and John Warner famously developed the 12 Principles of Green Chemistry in 1998 as a framework for minimizing the environmental impact of chemical products and processes</p></div> <h2><span class="TextRun SCXW173858242 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW173858242 BCX0"> </span></span></h2> <h3>Eliminating microplastics in magnetic bead based separation</h3> <p><span data-contrast="auto">“Initially, we were thinking just of the particle itself; there’s no microplastic, and that’s great,” said project R&D Scientist Maren Johansen. “But then with the 12 Principles of Green Chemistry, we realized that there were a lot of other things we could do. We’ve really looked into a lot of different aspects.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“I think the beauty of what we’ve done with this project is that it’s not just the microplastic. Everything about the product has been built with sustainability in mind,” said Lund. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h3>Reduction of energy consumption and resource allocations</h3> <p><span data-contrast="auto">Just in reducing the number of production steps and washes, R&D scientists have dramatically cut back on energy and resources </span><span data-contrast="none">—</span><span data-contrast="auto"> saving 45 tons of organic solvent, 90 tons of water, and 60 kg of plastic for every 100 kg of final product. The team also swapped out traditional solvents for biorenewable alternatives and for scientists who prefer to skip animal products, avoided using bovine serum albumin (BSA).<sup>4</sup></span><span data-contrast="auto"> </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">And the integrative thoughtfulness of DynaGreen doesn’t end at the production line. It shines through just as strongly as the beads are loaded onto the shipping truck, and again when they’re in the hands of the researchers who will rely on them. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h3>Waste reduction and refining product packaging</h3> <p><span data-contrast="auto">DynaGreen packaging has been streamlined to the essentials only, with smaller vials and more compact cartons. The new beads also ship at ambient temperatures, reducing the energy impact of cold transportation. Researchers will find no polystyrene foam in their DynaGreen shipments, nor will they find highly toxic components like sodium azide. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“I really like the team’s approach,” said Cristina Van Loy, the project’s sustainability technical lead. “They didn’t only focus on the product itself but looked at the whole life cycle. They engaged to talk about product components, the way it was packaged and transported, the way it was manufactured. We even had labs at that site participate in My Green Lab’s Green Lab Certification Program, to help further drive sustainable practices in the lab.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <div id="attachment_1750" style="width: 960px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-1750" class="wp-image-1750" title="Changing DynaGreen product packaging design improved storage space efficiency by more than three times. " src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-1024x417.jpg" alt="DynaGreen packaging is designed with space efficiency in mind " width="950" height="387" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-1024x417.jpg 1024w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-300x122.jpg 300w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-768x313.jpg 768w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging.jpg 1482w" sizes="(max-width: 950px) 100vw, 950px" /><p id="caption-attachment-1750" class="wp-caption-text">Changing a research product’s packaging design can dramatically improve storage space efficiency, as demonstrated in before and after images of storage bins at a distribution center in Bleiswijk, Netherlands containing redesigned Thermo Fisher Scientific protein biology kits. You can access more information on how <a href="https://www.thermofisher.com/us/en/home/about-us/product-stewardship.html">sustainable product packaging</a> is part of the company’s framework.</p></div> <div id="attachment_1749" style="width: 945px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-1749" class="wp-image-1749 size-full" title="Transforming product package (A) to a more efficient design (B) and comparing the difference in space savings (C). " src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-2.jpg" alt="Transforming product packaging to a more efficient design" width="935" height="586" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-2.jpg 935w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-2-300x188.jpg 300w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-2-768x481.jpg 768w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/Packaging-2-320x200.jpg 320w" sizes="(max-width: 935px) 100vw, 935px" /><p id="caption-attachment-1749" class="wp-caption-text">The transformation of a former tube kit packaging design (shown in column A) to a new standardized design (shown in column B) cut down on paper waste. Smaller package sizes tripled the amount of product that can be stored in the same shelf space (comparison between old and new package designs shown in column C).</p></div> <p> </p> <h2>In labs, performance criteria must be met before transitioning to greener technologies.</h2> <p><span data-contrast="auto">Of course, the promise of a more sustainably-produced bead rings hollow if it comes at the expense of the science. In the world of medical research, where research outcomes and the people who rely on them lie somewhere downstream, there’s no room for compromising on performance. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“The customers were so clear that they really want quality,” said project scientist Janne Eidem. “They didn’t want </span><i><span data-contrast="auto">good-’ish’</span></i><span data-contrast="auto"> and green. They want it to be good and green.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">The DynaGreen R&D team members in Norway were always conscious of the fact that fellow scientists would not accept a sub-performing alternative. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“In the beginning, we just tried to vary a lot of the different recipe parameters to see how it affected the size and the magnetic properties and the yield, and of course reproducibility has been really important,” said Johansen.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Altogether, they tested between 500 and 800 prototypes and benchmarked against Dynabeads and other top-performing beads on the market. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">With so much careful optimization built upon the foundation of Dynabeads chemistry and Ugelstad’s home-grown expertise, Johansen and her colleagues are confident that DynaGreen performs as well or better than similar beads. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h3>DynaGreen performance data validated</h3> <div id="attachment_1745" style="width: 720px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-1745" class="wp-image-1745 size-full" title="DynaGreen Protein A beads outperformed competitors in both direct and indirect immunoprecipitation (IP) workflows." src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/002-Protein-A-Gel.jpg" alt=" DynaGreen Protein A beads comparison data for immunoprecipitation (IP) workflows" width="710" height="607" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/002-Protein-A-Gel.jpg 710w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/002-Protein-A-Gel-300x256.jpg 300w" sizes="(max-width: 710px) 100vw, 710px" /><p id="caption-attachment-1745" class="wp-caption-text">DynaGreen Protein A beads outperformed all competitors in both direct and indirect immunoprecipitation (IP) workflows.</p></div> <div id="attachment_1744" style="width: 879px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-1744" class="size-full wp-image-1744" src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/003-Protein-AG-Gel.jpg" alt="DynaGreen protein A/G beads outperformed all competitors in the indirect IP workflow. DynaGreen Anti IgG-Fc beads gave the cleanest IP, while pulling down a comparable amount of target to Pierce A/G beads (indirect workflow) or to SeraMag Speed beads protein A/G and Sure Beads Protein G (direct workflow). " width="869" height="622" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/003-Protein-AG-Gel.jpg 869w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/003-Protein-AG-Gel-300x215.jpg 300w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/003-Protein-AG-Gel-768x550.jpg 768w" sizes="(max-width: 869px) 100vw, 869px" /><p id="caption-attachment-1744" class="wp-caption-text">DynaGreen protein A/G beads outperformed all competitors in the indirect IP workflow. DynaGreen Anti IgG-Fc beads gave the cleanest IP, while pulling down a comparable amount of target to Pierce A/G beads (indirect workflow) or to SeraMag Speed beads protein A/G and Sure Beads Protein G (direct workflow).</p></div> <p> </p> <h3>Where performance meets sustainable biotechnology</h3> <p><span data-contrast="auto">In several important ways, these beads actually raise the bar for performance. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Their unique submicron size translates to a higher surface area for faster, more efficient target binding. Likewise, DynaGreen beads’ uniformity and monodispersity are excellent for reproducibility.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">All told, the recommended automated or manual IP workflow clocks in under 90 minutes. It’s an ideal combination of speed and precision that, in practice, means that researchers can knock out their entire experimental workflow in a single working day and use fewer beads while doing it. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“We’ve gone from larger beads — 4.5 or 5 microns — down to 2.8 microns, to 1 micron. Now we’re going beyond, to 0.3 micron beads,” said Research Fellow Geir Fonnum, who has worked on Ugelstad particle technology at the Norway sites for 23 years. “What this gives you is a higher surface area per gram, and your beads will have higher capacity. You can use smaller amounts per assay. Instead of using, say, 1.5 milligrams, maybe you can go down to 0.5 milligrams.” </span></p> <h2> Planning ahead for sustainable product design</h2> <p><span data-contrast="auto">The technology behind has DynaGreen has deep roots in Norway, but the principle of sustainable design innovation is one that is much more widely ingrained within the wider global mission of Thermo Fisher Scientific. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">The company has committed to achieving net-zero emissions by 2050, which includes reductions in the areas of operations, supply chain, and product use and end of life. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Cristina Van Loy and Lori Graham, both former bench scientists, now advise the company’s life scientists on sustainability issues. They too see sustainability as a holistic process, fully interwoven from the beginning. And prevention is key. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“It’s generally accepted that about 80% of a product’s environmental impact is decided at the design phase. So rather than trying to solve problems at the very end, you really want to be designing with the environment in mind,” said Graham.</span><span data-contrast="auto"><sup>5</sup></span><span data-contrast="auto"> </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Van Loy views prevention like a faucet: “I am very interested in prevention. It’s best if we turn down or turn off the faucet to prevent waste rather than trying to clean up afterwards. Can we start at the beginning with that sustainability thought process in mind?” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Scientist-customers are asking more from their manufacturing partners to help them reach their own sustainability goals, including reducing waste in the lab. They want more sustainable options. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">Graham recognizes this desire because she felt it herself as a researcher. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“I worked in the lab for about 12 years. And for me there was a disconnect between what I was experiencing in the lab and what I was trying to do at home. In the lab, you’ve got single-use plastic waste, hazardous chemicals, energy-intensive instruments, all of that. It was not easy working in a lab environment every day, seeing the environmental impact and not always having the tools and opportunities to do anything about it,” said Graham. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“That was early in my career, and that’s what has led me now to a focused role in sustainability. I want to try to do something to help other researchers be able to conduct science in a more sustainable way.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">It also stands to reason that scientists are some of the most savvy, discerning customers out there when it comes to making laboratory purchases – they want data transparency in their tool choice as much as they do in their daily work. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h2>Sustainability with ACT: the Environmental Impact Factor Label</h2> <p><span data-contrast="auto">“People may be hesitant to buy green products,” said Lund. “We don’t want that to be the case, so we want to be as transparent as possible with our green credentials.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><img loading="lazy" decoding="async" class="wp-image-1753 size-full" src="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/ACTLabel.png" alt="The ACT label is designed to make the process of comparing and choosing sustainable lab products easier for scientist consumers. It emphasizes accountability (A), consistency (C), and transparency (T) around manufacturing, energy and water use, packaging, and end-of-life disposal of a product." width="589" height="371" srcset="https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/ACTLabel.png 589w, https://www.thermofisher.com/blog/life-in-the-lab/wp-content/uploads/sites/10/2023/01/ACTLabel-300x189.png 300w" sizes="(max-width: 589px) 100vw, 589px" /></p> <p><span data-contrast="auto">Thermo Fisher is an active participant in the </span><a href="https://act.mygreenlab.org/"><span data-contrast="none">ACT label program</span></a><span data-contrast="auto"> developed by the independent nonprofit My Green Lab. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">The ACT label is designed to make the process of comparing and choosing sustainable lab products easier for scientist consumers. It emphasizes accountability (A), consistency (C), and transparency (T) around manufacturing, energy and water use, packaging, and end-of-life disposal of a product.<sup>6</sup></span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“You’ll often hear it equated to a nutrition label,” said Graham.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">To date, Thermo Fisher has </span><a href="https://corporate.thermofisher.com/us/en/index/corporate-social-responsibility/environment/responsible-products-and-services.html?icid=bid_cbu_sbu_r01_co_cp1450_pjt9002_blg40689_0so_blg_il_awa_og_s00_Blog_DynaGreen"><span data-contrast="none">labelled 470 products</span></a><span data-contrast="auto">, along with 250+ Energy Star™ -certified products. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h2>Sustainability is here to stay for biotech companies <b><span data-contrast="auto"><br /> </span></b></h2> <p><span data-contrast="auto">In talking to the scientists and product specialists who worked on DynaGreen, it’s clear that they’re all-in when it comes to sustainability. They count themselves as part of the scientific community looking to act, shoulder-to-shoulder with their customers.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“If we’re really going to change the world, and address climate change, everyone has to do something,” said Fonnum. “All of these small changes will mean something to the world in the end. And I think that’s an important mission that we as scientists, as product developers, have. Everyone in the world has to have that mission for it to succeed.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">During his doctoral studies, Fonnum attended Ugelstad’s lectures. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“Ugelstad was the archetype of a professor. He was deeply interested in the technical. He was not a person that went into the lab and made it work, but he had an enormous enthusiasm,” said Fonnum. “He travelled around the world and because of his enthusiasm, got other academic people — immunologists and cell biologists — interested in his polymer chemistry invention. He succeeded because he could get people to work together.”</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“I can see the same type of enthusiasm in this project here – that people really do the best they can, and really like to work with this type of problem.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">For Vedrana Grcic, who works on the marketing side of DynaGreen, this technology is more than an iterative step in the direction of sustainability for the field. It’s a better way of doing things, guided as much by a collective vision for the future world as by commercial need. </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“In business and marketing case studies, people often talk about Kodak,” said Grcic. “Kodak is a company that enabled amateur photography through film and photography supplies, and in time invented the first handheld digital camera. Despite this, their downfall was in that they refused to accept and support the development of this new digital technology which rivalled its core product film. They were overtaken by the likes of Sony and Canon and were left behind. Nobody uses Kodak anymore. And I feel like, this is exactly what the Thermo Fisher Scientific magnetic beads team is not doing.</span> <span data-contrast="auto">Even though we’re market-leading in magnetic beads technology, and we have our heritage and knowledge that our technology is one of the best out there – we’re still creating this new product because we believe so passionately in what it represents as the world moves in a more sustainable direction. For me, this is the essence of the daring innovation of our team.”</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="auto">“We’re not getting left behind, and we’re not just doing this for commercial reasons. We’re doing this because it’s what scientists want and because it’s also the right thing to do.” </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h3><b><span data-contrast="none">Learn more about DynaGreen at </span></b><a href="https://www.thermofisher.com/us/en/home/life-science/protein-biology/protein-assays-analysis/immunoprecipitation/dynagreen-magnetic-beads.html?cid=bid_cbu_sbu_r01_co_cp1450_pjt9002_blg40689_0so_blg_il_awa_og_s00_Blog_DynaGreen"><b><span data-contrast="none">thermofisher.com/dynagreen </span></b></a><b><span data-contrast="none">»</span></b><span data-ccp-props="{"201341983":0,"335559738":40,"335559739":0,"335559740":259}"> </span></h3> <p><span data-contrast="none"> </span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><i><span data-contrast="none">Want to read more stories like this? </span></i><a href="https://www.thermofisher.com/us/en/home/global/forms/connect-science-subscribe-giveaway.html?cid=bid_cbu_sbu_r01_co_cp1450_pjt9002_blg40689_0so_blg_il_awa_og_s00_Blog_DynaGreen"><i><span data-contrast="none">Subscribe to Connect to Science</span></i></a><i><span data-contrast="none">, your portal for life science news.</span></i><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h3>References</h3> <ol> <li><span class="TextRun SCXW250108516 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SpellingErrorV2Themed SCXW250108516 BCX0" data-ccp-parastyle="Normal (Web)">Sintef</span><span class="NormalTextRun SCXW250108516 BCX0" data-ccp-parastyle="Normal (Web)">. “1978: Tiny Spheres to Treat Cancer – and Much More.” SINTEF. SINTEF, March 23, 2021. https://www.sintef.no/en/sintef-group/timeline/1978-tiny-spheres-to-treat-cancer-and-much-more/. </span></span><span class="EOP SCXW250108516 BCX0" data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559685":567,"335559740":240,"335559991":567}"> </span></li> <li><span class="TextRun SCXW119081152 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW119081152 BCX0" data-ccp-parastyle="Normal (Web)">“The History of </span><span class="NormalTextRun SpellingErrorV2Themed SCXW119081152 BCX0" data-ccp-parastyle="Normal (Web)">Dynabeads</span><span class="NormalTextRun SCXW119081152 BCX0" data-ccp-parastyle="Normal (Web)"> and </span><span class="NormalTextRun SCXW119081152 BCX0" data-ccp-parastyle="Normal (Web)">Biomagnetic</span><span class="NormalTextRun SCXW119081152 BCX0" data-ccp-parastyle="Normal (Web)"> Separation.” </span><span class="NormalTextRun SpellingErrorV2Themed SCXW119081152 BCX0" data-ccp-parastyle="Normal (Web)">Thermo</span><span class="NormalTextRun SCXW119081152 BCX0" data-ccp-parastyle="Normal (Web)"> Fisher Scientific. Accessed November 21, 2022. https://www.thermofisher.com/us/en/home/brands/product-brand/dynal/the-history-of-dynabeads.html. </span></span></li> <li><span class="EOP SCXW119081152 BCX0" data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559685":567,"335559740":240,"335559991":567}"> <span class="TextRun Highlight SCXW216973771 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="none"><span class="NormalTextRun SCXW216973771 BCX0" data-ccp-parastyle="endnote text">Anastas</span><span class="NormalTextRun SCXW216973771 BCX0" data-ccp-parastyle="endnote text">, P. T.; Warner, J. C. Green Chemistry: Theory and Practice, Oxford University Press: New York, 1998, p.30. </span></span><span class="EOP SCXW216973771 BCX0" data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></span></li> <li><span data-contrast="auto">Garnett, Tara. “Livestock-Related Greenhouse Gas Emissions: Impacts and Options for Policy Makers.” </span><i><span data-contrast="auto">Environmental Science & Policy</span></i><span data-contrast="auto"> 12, no. 4 (February 26, 2009): 491–503. https://doi.org/10.1016/j.envsci.2009.01.006.</span></li> <li><span data-contrast="auto"><span class="TextRun SCXW222438368 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW222438368 BCX0" data-ccp-parastyle="Normal (Web)">“Sustainable Product Policy.” EU Science Hub. European Commission. Accessed November 21, 2022. https://joint-research-centre.ec.europa.eu/scientific-activities-z/sustainable-product-policy_en. </span></span></span></li> <li><span data-contrast="auto">ACT Label. My Green Lab. Accessed November 21, 2022. https://act.mygreenlab.org/. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559685":567,"335559740":240,"335559991":567}"> </span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li> </ol> <p> </p> <p><span data-ccp-props="{}"><em>For Research Use Only. Not for use in diagnostic procedures. </em></span></p> <aside class="mashsb-container mashsb-main "><div class="mashsb_above_buttons">Share this article </div><div class="mashsb-box"><div class="mashsb-count mash-large" style="float:left"><div class="counts mashsbcount">152</div><span class="mashsb-sharetext">SHARES</span></div><div class="mashsb-buttons"><a class="mashicon-facebook mash-large mashsb-noshadow" href="https://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.thermofisher.com%2Fblog%2Flife-in-the-lab%2Fthe-future-of-magnetic-beads-is-plastic-free%2F" target="_top" rel="nofollow"><span class="icon"></span><span class="text">Facebook</span></a><a class="mashicon-twitter mash-large mashsb-noshadow" href="https://twitter.com/intent/tweet?text=The%20Future%20of%20Magnetic%20Beads%20is%20Plastic-Free&url=https://www.thermofisher.com/blog/life-in-the-lab/?p=1735&via=thermofisher" target="_top" rel="nofollow"><span class="icon"></span><span class="text">Twitter</span></a><a 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