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Koch Institute for Integrative Cancer Research - Wikipedia

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class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">MIT cancer research center</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">This article is about the MIT cancer research center. For the German disease control and prevention institution, see <a href="/wiki/Robert_Koch_Institute" title="Robert Koch Institute">Robert Koch Institute</a>.</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox vcard"><caption class="infobox-title fn org">Koch Institute for Integrative Cancer Research at MIT</caption><tbody><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/File:Koch_Institute_Logo.png" class="mw-file-description" title="Logo of the MIT Koch Institute"><img alt="Logo of the MIT Koch Institute" src="//upload.wikimedia.org/wikipedia/en/thumb/4/44/Koch_Institute_Logo.png/300px-Koch_Institute_Logo.png" decoding="async" width="300" height="30" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/44/Koch_Institute_Logo.png/450px-Koch_Institute_Logo.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/4/44/Koch_Institute_Logo.png/600px-Koch_Institute_Logo.png 2x" data-file-width="900" data-file-height="91" /></a></span></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em">Established</th><td class="infobox-data">October 9, 2007</td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em">Research&#160;type</th><td class="infobox-data category">Basic (non-clinical) research</td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><a href="/wiki/Budget" title="Budget">Budget</a></th><td class="infobox-data">$93.2 million<sup id="cite_ref-PR08_1-0" class="reference"><a href="#cite_note-PR08-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;">Field&#160;of research</div></th><td class="infobox-data category"><a href="/wiki/Cancer_research" title="Cancer research">Cancer research</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><a href="/wiki/Director_(business)" title="Director (business)">Director</a></th><td class="infobox-data agent">Matthew Vander Heiden</td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><a href="/wiki/Faculty_(division)" title="Faculty (division)">Faculty</a></th><td class="infobox-data">29<sup id="cite_ref-Faculty_2-0" class="reference"><a href="#cite_note-Faculty-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><a href="/wiki/Employment" title="Employment">Staff</a></th><td class="infobox-data">500<sup id="cite_ref-Faculty_2-1" class="reference"><a href="#cite_note-Faculty-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em">Address</th><td class="infobox-data label">77 Massachusetts Ave.<br />Building 76</td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em">Location</th><td class="infobox-data"><a href="/wiki/Cambridge,_Massachusetts" title="Cambridge, Massachusetts">Cambridge, Massachusetts</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><a href="/wiki/Campus" title="Campus">Campus</a></th><td class="infobox-data">180,000 square feet (17,000&#160;m<sup>2</sup>)</td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><a href="/wiki/Consortium" title="Consortium">Affiliations</a></th><td class="infobox-data"><a href="/wiki/National_Cancer_Institute" title="National Cancer Institute">National Cancer Institute</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em"><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;">Operating agency</div></th><td class="infobox-data"><a href="/wiki/Massachusetts_Institute_of_Technology" title="Massachusetts Institute of Technology">Massachusetts Institute of Technology</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.65em">Website</th><td class="infobox-data"><span class="url"><a rel="nofollow" class="external text" href="https://ki.mit.edu">ki.mit.edu</a></span></td></tr></tbody></table> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:MIT-Koch-Institute.jpg" class="mw-file-description"><img alt="View of a seven story building seen from a grassy courtyard" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/MIT-Koch-Institute.jpg/220px-MIT-Koch-Institute.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/MIT-Koch-Institute.jpg/330px-MIT-Koch-Institute.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/MIT-Koch-Institute.jpg/440px-MIT-Koch-Institute.jpg 2x" data-file-width="6000" data-file-height="4000" /></a><figcaption>Koch Institute for Integrative Cancer Research</figcaption></figure> <p>The <b>Koch Institute for Integrative Cancer Research at MIT</b> (<span class="rt-commentedText nowrap"><span class="IPA nopopups noexcerpt" lang="en-fonipa"><a href="/wiki/Help:IPA/English" title="Help:IPA/English">/<span style="border-bottom:1px dotted"><span title="&#39;k&#39; in &#39;kind&#39;">k</span><span title="/oʊ/: &#39;o&#39; in &#39;code&#39;">oʊ</span><span title="&#39;k&#39; in &#39;kind&#39;">k</span></span>/</a></span></span> <a href="/wiki/Help:Pronunciation_respelling_key" title="Help:Pronunciation respelling key"><i title="English pronunciation respelling"><span style="font-size:90%">KOHK</span></i></a>; also referred to as the <b>Koch Institute</b> or <b>KI</b>) is a <a href="/wiki/Cancer_research" title="Cancer research">cancer research</a> center affiliated with the <a href="/wiki/Massachusetts_Institute_of_Technology" title="Massachusetts Institute of Technology">Massachusetts Institute of Technology</a> (MIT) located in <a href="/wiki/Cambridge,_Massachusetts" title="Cambridge, Massachusetts">Cambridge</a>, <a href="/wiki/Massachusetts" title="Massachusetts">Massachusetts</a>, <a href="/wiki/United_States" title="United States">United States</a>. The institute is one of seven National Cancer Institute-designated basic laboratory <a href="/wiki/NCI-designated_Cancer_Center" title="NCI-designated Cancer Center">cancer centers</a> in the United States.<sup id="cite_ref-NCI_3-0" class="reference"><a href="#cite_note-NCI-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p><p>The institute was launched in October 2007 with a $100 million grant from <a href="/wiki/David_H._Koch" class="mw-redirect" title="David H. Koch">David H. Koch</a> and the 180,000 square feet (17,000&#160;m<sup>2</sup>) research facility opened in December 2010, replacing the MIT Center for Cancer Research (CCR).<sup id="cite_ref-Gift_4-0" class="reference"><a href="#cite_note-Gift-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-TCHE_5-0" class="reference"><a href="#cite_note-TCHE-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> The institute is affiliated with 29 MIT faculty members in both the <a href="/wiki/Massachusetts_Institute_of_Technology_School_of_Engineering" title="Massachusetts Institute of Technology School of Engineering">Schools of Engineering</a> and <a href="/wiki/Massachusetts_Institute_of_Technology_School_of_Science" title="Massachusetts Institute of Technology School of Science">Science</a>.<sup id="cite_ref-Groundbreak_6-0" class="reference"><a href="#cite_note-Groundbreak-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit&amp;section=1" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In 1974, the Center for Cancer Research was founded by 1969 <a href="/wiki/Nobel_Prize_in_Physiology_or_Medicine" title="Nobel Prize in Physiology or Medicine">Nobel laureate</a> <a href="/wiki/Salvador_Luria" title="Salvador Luria">Salvador Luria</a> to study basic biological processes related to cancer. The center researches the genetic and molecular basis of cancer, how alterations in cellular processes affect cell growth and behavior, and how the immune system develops and recognizes antigens.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> The CCR was both a physical research center as well as an organizing body for the larger MIT cancer research community of over 500 researchers.<sup id="cite_ref-PR07_8-0" class="reference"><a href="#cite_note-PR07-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> Financial support for the CCR primarily came from Center Core grant from the National Cancer Institute as well as research project grants from the <a href="/wiki/National_Institutes_of_Health" title="National Institutes of Health">National Institutes of Health</a>, <a href="/wiki/Howard_Hughes_Medical_Institute" title="Howard Hughes Medical Institute">Howard Hughes Medical Institute</a>, and foundation support. The CCR research groups were successful in identifying <a href="/wiki/Oncogene" title="Oncogene">oncogenes</a>, immunology of <a href="/wiki/T_lymphocytes" class="mw-redirect" title="T lymphocytes">T lymphocytes</a>, and roles of various cellular proteins. The CCR produced four Nobel Laureates: <a href="/wiki/David_Baltimore" title="David Baltimore">David Baltimore</a> (1975), <a href="/wiki/Susumu_Tonegawa" title="Susumu Tonegawa">Susumu Tonegawa</a> (1987), <a href="/wiki/Phillip_Sharp" class="mw-redirect" title="Phillip Sharp">Phillip Sharp</a> (1993), and <a href="/wiki/H._Robert_Horvitz" title="H. Robert Horvitz">H. Robert Horvitz</a> (2002).<sup id="cite_ref-Past,_present_9-0" class="reference"><a href="#cite_note-Past,_present-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup> </p><p>In 2006, President <a href="/wiki/Susan_Hockfield" title="Susan Hockfield">Susan Hockfield</a> announced plans for a new CCR center to support and expand cancer research performed by biologists and engineers.<sup id="cite_ref-PR07_8-1" class="reference"><a href="#cite_note-PR07-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Past,_present_9-1" class="reference"><a href="#cite_note-Past,_present-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup> A $20 million grant was made by the Ludwig Fund, part of <a href="/wiki/Ludwig_Cancer_Research" title="Ludwig Cancer Research">Ludwig Cancer Research</a>, in November 2007 to support a Center for Molecular Oncology to be administered by the CCR.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup> In 2007, MIT announced it had received a $100 million gift from <a href="/wiki/David_H._Koch" class="mw-redirect" title="David H. Koch">David H. Koch</a>, the executive vice president of the oil conglomerate <a href="/wiki/Koch_Industries" class="mw-redirect" title="Koch Industries">Koch Industries</a>. Koch graduated from MIT with bachelor's and master's degrees in <a href="/wiki/Chemical_engineering" title="Chemical engineering">chemical engineering</a> and served on the university's board of directors since 1988. Koch survived a <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a> diagnosis in 1992, previously donated $25 million over ten years to MIT to support cancer research, and is the namesake of the university's <a href="/wiki/Koch_Biology_Building" class="mw-redirect" title="Koch Biology Building">Koch Biology Building</a>.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">&#91;</span>11<span class="cite-bracket">&#93;</span></a></sup> The gift supported the construction of the estimated $240–$280 million facility, on the condition that MIT build the center even if fund raising fell short.<sup id="cite_ref-TCHE_5-1" class="reference"><a href="#cite_note-TCHE-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mission">Mission</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit&amp;section=2" title="Edit section: Mission"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The Koch Institute emphasizes basic research into how cancer is caused, progresses, and responds to treatment. Unlike many other NCI Cancer Centers, it will not provide medical care or conduct clinical research, but it partners with oncology centers such as the <a href="/wiki/Dana%E2%80%93Farber_Cancer_Institute" title="Dana–Farber Cancer Institute">Dana-Farber Cancer Institute</a> and <a href="/wiki/Massachusetts_General_Hospital" title="Massachusetts General Hospital">Massachusetts General Hospital</a>'s Cancer Center.<sup id="cite_ref-FAQ_12-0" class="reference"><a href="#cite_note-FAQ-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup> The institute combines the existing faculty of the CCR with an equivalent number of engineering faculty to promote interdisciplinary approaches to diagnosing, monitoring, and treating cancer.<sup id="cite_ref-PR08_1-1" class="reference"><a href="#cite_note-PR08-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p><p>The Koch Institute has identified five areas of research that it believes are critical for controlling <a href="/wiki/Cancer" title="Cancer">cancer</a>: Developing <a href="/wiki/Nanotechnology" title="Nanotechnology">nanotechnology</a>-based cancer therapeutics, creating novel devices for cancer detection and monitoring, exploring the molecular and cellular basis of <a href="/wiki/Metastasis" title="Metastasis">metastasis</a>, advancing personalized medicine through analysis of cancer pathways and drug resistance, engineering the <a href="/wiki/Immune_system" title="Immune system">immune system</a> to fight cancer.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">&#91;</span>13<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Affiliates">Affiliates</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit&amp;section=3" title="Edit section: Affiliates"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The Koch Institute is home to faculty members from various departments, including Biology, Chemistry, Mechanical Engineering, and Biological Engineering; more than 40 laboratories and 500 researchers across the campus.<sup id="cite_ref-PR08_1-2" class="reference"><a href="#cite_note-PR08-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Koch Institute faculty teach classes at MIT, as well as train graduate and undergraduate students as well as postdoctoral fellows. The Koch Institute is affiliated with two current Nobel Laureates (Horvitz and Sharp), eighteen members of the <a href="/wiki/United_States_National_Academy_of_Sciences" class="mw-redirect" title="United States National Academy of Sciences">National Academy of Sciences</a>, eight members of the <a href="/wiki/National_Academy_of_Engineering" title="National Academy of Engineering">National Academy of Engineering</a>, five <a href="/wiki/National_Medal_of_Science" title="National Medal of Science">National Medal of Science</a> laureates, and ten <a href="/wiki/Howard_Hughes_Medical_Institute" title="Howard Hughes Medical Institute">Howard Hughes Medical Institute</a> investigators, and one <a href="/wiki/MacArthur_Foundation_Fellowship" class="mw-redirect" title="MacArthur Foundation Fellowship">MacArthur Foundation Fellowship</a> recipient.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">&#91;</span>14<span class="cite-bracket">&#93;</span></a></sup> </p><p>Notable faculty members affiliated with the Koch Institute include:<sup id="cite_ref-Faculty_2-2" class="reference"><a href="#cite_note-Faculty-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 22em;"> <ul><li><a href="/wiki/Angela_M._Belcher" class="mw-redirect" title="Angela M. Belcher">Angela M. Belcher</a></li> <li><a href="/wiki/Sangeeta_N._Bhatia" class="mw-redirect" title="Sangeeta N. Bhatia">Sangeeta N. Bhatia</a></li> <li><a href="/wiki/Paula_T._Hammond" title="Paula T. Hammond">Paula T. Hammond</a></li> <li><a href="/wiki/Michael_Hemann" title="Michael Hemann">Michael Hemann</a></li> <li><a href="/wiki/Nancy_Hopkins_(scientist)" title="Nancy Hopkins (scientist)">Nancy Hopkins</a></li> <li><a href="/wiki/Richard_O._Hynes" class="mw-redirect" title="Richard O. Hynes">Richard O. Hynes</a></li> <li><a href="/wiki/Tyler_Jacks" title="Tyler Jacks">Tyler Jacks</a></li> <li><a href="/wiki/Robert_S._Langer" title="Robert S. Langer">Robert S. Langer</a></li> <li><a href="/wiki/Phillip_Sharp" class="mw-redirect" title="Phillip Sharp">Phillip Sharp</a></li> <li><a href="/wiki/Michael_B._Yaffe" title="Michael B. Yaffe">Michael B. Yaffe</a></li></ul></div> <div class="mw-heading mw-heading2"><h2 id="Building">Building</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit&amp;section=4" title="Edit section: Building"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Campus_of_the_Massachusetts_Institute_of_Technology" title="Campus of the Massachusetts Institute of Technology">Campus of the Massachusetts Institute of Technology</a></div> <p>The 180,000 square feet (17,000&#160;m<sup>2</sup>) research facility is located on the corner of Main Street and Ames Street near <a href="/wiki/Kendall_Square" title="Kendall Square">Kendall Square</a> in <a href="/wiki/Cambridge,_Massachusetts" title="Cambridge, Massachusetts">Cambridge, Massachusetts</a>. The building is located opposite the <a href="/wiki/Whitehead_Institute" title="Whitehead Institute">Whitehead Institute</a> and <a href="/wiki/Broad_Institute" title="Broad Institute">Broad Institute</a> and near the biology and chemical engineering buildings on the north-eastern end of <a href="/wiki/Campus_of_the_Massachusetts_Institute_of_Technology" title="Campus of the Massachusetts Institute of Technology">MIT's campus</a>. MIT broke ground on Building 76 in March 2008,<sup id="cite_ref-Groundbreak_6-1" class="reference"><a href="#cite_note-Groundbreak-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> a topping-off ceremony was held in February 2009,<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">&#91;</span>15<span class="cite-bracket">&#93;</span></a></sup> and the building was dedicated on March 4, 2011.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">&#91;</span>16<span class="cite-bracket">&#93;</span></a></sup> </p><p>The building was designed by Cambridge-based architecture firm Ellenzweig, which designed several other buildings on the MIT campus.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">&#91;</span>17<span class="cite-bracket">&#93;</span></a></sup> The structural engineer was <a href="/wiki/LeMessurier_Consultants" title="LeMessurier Consultants">LeMessurier</a>. Designed to encourage interaction and collaboration, the building employs both dedicated lab space as well as common areas, and features a ground-floor gallery exhibiting art and technical displays related to biomedical research.<sup id="cite_ref-PR08_1-3" class="reference"><a href="#cite_note-PR08-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> The building includes facilities for bioinformatics and computing, genomics, <a href="/wiki/Proteomic" class="mw-redirect" title="Proteomic">proteomics</a> and <a href="/wiki/Flow_cytometry" title="Flow cytometry">flow cytometry</a>, large-scale cell and animal facilities for genetic engineering and testing, advanced imaging equipment, and nanomaterials characterization labs.<sup id="cite_ref-Groundbreak_6-2" class="reference"><a href="#cite_note-Groundbreak-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Activity_since_2007">Activity since 2007</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit&amp;section=5" title="Edit section: Activity since 2007"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The KI remains funded by a NCI center grant as well as 110 fully funded projects. Research volume in 2017–2018 totaled $93.2 million.<sup id="cite_ref-PR08_1-4" class="reference"><a href="#cite_note-PR08-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> As of 2009<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit">&#91;update&#93;</a></sup>, notable grants include Mouse Models of Cancer Consortium, Integrative Cancer Biology Program, and the Centers for Excellence in Nanotechnology and Cancer.<sup id="cite_ref-FAQ_12-1" class="reference"><a href="#cite_note-FAQ-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup> </p><p>In 2011, scientists at the institute pinpointed a genetic change that makes lung cancer more likely to spread around the body and may help scientists develop new drugs to fight secondary tumors.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> </p><p>In 2020, <a href="/wiki/Alex_K._Shalek" title="Alex K. Shalek">Alex K. Shalek</a>, Christopher Love, Travis Hughes and Marc Wadsworth developed an updated protocol for the commonly used low-input RNA sequencing method Seq-Well, increasing output resolution by ten times.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">&#91;</span>19<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit&amp;section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-PR08-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-PR08_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-PR08_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-PR08_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-PR08_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-PR08_1-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://web.mit.edu/annualreports/pres18/">"Annual Reports to the President, 2017–2018: Koch Institute for Integrative Cancer Research"</a>. Office of the President, Massachusetts Institute of Technology<span class="reference-accessdate">. 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Archived from <a rel="nofollow" class="external text" href="http://web.mit.edu/newsoffice/2009/facilities-upgrades-0902.html">the original</a> on September 6, 2009.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.atitle=While+you+were+out&amp;rft.date=2009-09-02&amp;rft_id=http%3A%2F%2Fweb.mit.edu%2Fnewsoffice%2F2009%2Ffacilities-upgrades-0902.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AKoch+Institute+for+Integrative+Cancer+Research" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBrobbey2008" class="citation news cs1">Brobbey, Valery (February 26, 2008). <a rel="nofollow" class="external text" href="http://tech.mit.edu/V128/N7/cancer.html">"Cancer Building Groundbreaking Scheduled"</a>. The Tech.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.atitle=Cancer+Building+Groundbreaking+Scheduled&amp;rft.date=2008-02-26&amp;rft.aulast=Brobbey&amp;rft.aufirst=Valery&amp;rft_id=http%3A%2F%2Ftech.mit.edu%2FV128%2FN7%2Fcancer.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AKoch+Institute+for+Integrative+Cancer+Research" class="Z3988"></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBriggs2011" class="citation news cs1">Briggs, Helen (April 7, 2011). <a rel="nofollow" class="external text" href="https://www.bbc.co.uk/news/health-12986522">"Gene clue to how cancer spreads"</a>. <i>BBC</i><span class="reference-accessdate">. Retrieved <span class="nowrap">21 April</span> 2011</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=BBC&amp;rft.atitle=Gene+clue+to+how+cancer+spreads&amp;rft.date=2011-04-07&amp;rft.aulast=Briggs&amp;rft.aufirst=Helen&amp;rft_id=https%3A%2F%2Fwww.bbc.co.uk%2Fnews%2Fhealth-12986522&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AKoch+Institute+for+Integrative+Cancer+Research" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.sciencedaily.com/releases/2020/10/201013134300.htm">"Technique to recover lost single-cell RNA-sequencing information: Boosting the efficiency of single-cell RNA-sequencing helps reveal subtle differences between healthy and dysfunctional cells"</a>. <i>ScienceDaily</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2021-02-17</span></span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=ScienceDaily&amp;rft.atitle=Technique+to+recover+lost+single-cell+RNA-sequencing+information%3A+Boosting+the+efficiency+of+single-cell+RNA-sequencing+helps+reveal+subtle+differences+between+healthy+and+dysfunctional+cells&amp;rft_id=https%3A%2F%2Fwww.sciencedaily.com%2Freleases%2F2020%2F10%2F201013134300.htm&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AKoch+Institute+for+Integrative+Cancer+Research" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Koch_Institute_for_Integrative_Cancer_Research&amp;action=edit&amp;section=7" title="Edit section: External links"><span>edit</span></a><span 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style="background:#A31F34; color:#FFFFFF; box-shadow: inset 2px 2px 0 #8A8B8C, inset -2px -2px 0 #8A8B8C;;;width:1%">Research</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abdul_Latif_Jameel_Poverty_Action_Lab" title="Abdul Latif Jameel Poverty Action Lab">Abdul Latif Jameel Poverty Action Lab</a></li> <li><a href="/wiki/Broad_Institute" title="Broad Institute">Broad Institute</a></li> <li>Center for <ul><li><a href="/wiki/Center_for_Bits_and_Atoms" title="Center for Bits and Atoms">Bits and Atoms</a></li> <li><a href="/wiki/MIT_Center_for_Information_Systems_Research" title="MIT Center for Information Systems Research">Information Systems Research</a></li> <li><a href="/wiki/MIT_Center_for_International_Studies" title="MIT Center for International Studies">International Studies</a></li> <li><a href="/wiki/MIT_Center_for_Theoretical_Physics" title="MIT Center for Theoretical 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href="/wiki/Massachusetts_Green_High_Performance_Computing_Center" title="Massachusetts Green High Performance Computing Center">Massachusetts Green High Performance Computing Center</a></li> <li><a href="/wiki/McGovern_Institute_for_Brain_Research" title="McGovern Institute for Brain Research">McGovern Institute</a></li> <li><a href="/wiki/MIT_Media_Lab" title="MIT Media Lab">Media Lab</a></li> <li><a href="/wiki/Massachusetts_Institute_of_Technology_Libraries" title="Massachusetts Institute of Technology Libraries">MIT Libraries</a></li> <li><a href="/wiki/MIT_Nuclear_Research_Reactor" title="MIT Nuclear Research Reactor">Nuclear Research Reactor</a></li> <li><a href="/wiki/Picower_Institute_for_Learning_and_Memory" title="Picower Institute for Learning and Memory">Picower Institute</a></li> <li><a href="/wiki/MIT_Plasma_Science_and_Fusion_Center" title="MIT Plasma Science and Fusion Center">Plasma Science and Fusion Center</a></li> <li>Research Laboratory of Electronics</li> <li><a href="/wiki/MIT_Senseable_City_Lab" title="MIT Senseable City Lab">Senseable City Lab</a></li> <li><a href="/wiki/Whitehead_Institute" title="Whitehead Institute">Whitehead Institute</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="background:#A31F34; color:#FFFFFF; box-shadow: inset 2px 2px 0 #8A8B8C, inset -2px -2px 0 #8A8B8C;;;width:1%">People</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/List_of_Massachusetts_Institute_of_Technology_alumni" title="List of Massachusetts Institute of Technology alumni">Alumni</a></li> <li><a href="/wiki/List_of_Massachusetts_Institute_of_Technology_faculty" title="List of Massachusetts Institute of Technology faculty">Faculty</a></li> <li><a href="/wiki/List_of_Institute_Professors_at_the_Massachusetts_Institute_of_Technology" class="mw-redirect" title="List of Institute Professors at the Massachusetts Institute of Technology">Institute Professors</a></li> <li><a href="/wiki/List_of_Presidents_of_the_Massachusetts_Institute_of_Technology" class="mw-redirect" title="List of Presidents of the Massachusetts Institute of Technology">Presidents</a></li> <li><a href="/wiki/William_Barton_Rogers" title="William Barton Rogers">William Barton Rogers</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="background:#A31F34; color:#FFFFFF; box-shadow: inset 2px 2px 0 #8A8B8C, inset -2px -2px 0 #8A8B8C;;;width:1%">Culture</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MIT_class_ring" title="MIT class ring">Brass Rat</a></li> <li><a href="/wiki/Caltech%E2%80%93MIT_rivalry" title="Caltech–MIT rivalry">Caltech rivalry</a></li> <li><a href="/wiki/Hacks_at_the_Massachusetts_Institute_of_Technology" title="Hacks at the Massachusetts Institute of Technology">Hacks</a></li> <li><a href="/wiki/Lemelson%E2%80%93MIT_Prize" title="Lemelson–MIT Prize">Lemelson–MIT Prize</a></li> <li><a href="/wiki/List_Visual_Arts_Center" title="List Visual Arts Center">List Visual Arts Center</a></li> <li><a href="/wiki/MIT_$100K_Entrepreneurship_Competition" title="MIT $100K Entrepreneurship Competition">MIT $100K</a></li> <li><a href="/wiki/MIT_Press" title="MIT Press">MIT Press</a></li> <li><i><a href="/wiki/MIT_Technology_Review" title="MIT Technology Review">MIT Technology Review</a></i></li> <li><a href="/wiki/MIT_Science_Fiction_Society" title="MIT Science Fiction Society">MIT Science Fiction Society</a></li> <li><a href="/wiki/MIT_Mystery_Hunt" title="MIT Mystery Hunt">Mystery Hunt</a></li> <li><a href="/wiki/Project_Athena" title="Project Athena">Project Athena</a></li> <li><a href="/wiki/Smoot" title="Smoot">Smoot</a></li> <li><a href="/wiki/Student_Information_Processing_Board" title="Student Information Processing Board">Student Information Processing Board</a></li> 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Hill (Dartmouth, Massachusetts)">Round Hill</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="background:#A31F34; color:#FFFFFF; box-shadow: inset 2px 2px 0 #8A8B8C, inset -2px -2px 0 #8A8B8C;;;width:1%">Athletics</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MIT_Engineers" title="MIT Engineers">Engineers</a></li> <li><a href="/wiki/Tech_Dinghy" title="Tech Dinghy">Tech Dinghy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="background:#A31F34; color:#FFFFFF; box-shadow: inset 2px 2px 0 #8A8B8C, inset -2px -2px 0 #8A8B8C;;;width:1%">Notable projects</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MIT_App_Inventor" title="MIT App Inventor">MIT App Inventor</a></li> <li><a href="/wiki/MIT_OpenCourseWare" title="MIT OpenCourseWare">MIT OpenCourseWare</a></li> <li><a href="/wiki/MITx" title="MITx">MITx</a></li> <li><a href="/wiki/Scratch_(programming_language)" title="Scratch (programming language)">Scratch</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Koch_family" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Koch_family" title="Template:Koch family"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Koch_family" title="Template talk:Koch family"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Koch_family" title="Special:EditPage/Template:Koch family"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Koch_family" style="font-size:114%;margin:0 4em"><a href="/wiki/Koch_family" title="Koch family">Koch family</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">First generation</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Harry_Koch_(businessman)" title="Harry Koch (businessman)">Harry Koch</a>: 1867–1942</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Second generation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fred_C._Koch" title="Fred C. Koch">Fred C. Koch</a>: 1900–1967</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Third generation</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Frederick_R._Koch" title="Frederick R. Koch">Frederick R. Koch</a>: 1933–2020</li> <li><a href="/wiki/Charles_Koch" title="Charles Koch">Charles Koch</a>: 1935</li> <li><a href="/wiki/David_Koch" title="David Koch">David Koch</a>: 1940–2019</li> <li><a href="/wiki/Julia_Koch" title="Julia Koch">Julia Koch</a>: 1962</li> <li><a href="/wiki/Bill_Koch_(businessman)" title="Bill Koch (businessman)">William Koch</a>: 1940</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Fourth generation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Elizabeth_Koch_(publisher)" title="Elizabeth Koch (publisher)">Elizabeth Koch</a>: 1976</li> <li><a href="/wiki/Chase_Koch" title="Chase Koch">Chase Koch</a>: 1977</li> <li>Wyatt&#160;: 1986</li> <li>William: 1997</li> <li>Charlotte: 1996</li> <li>Robin: 1999</li> <li>Kaitlin: 2006</li> <li>David Jr.: 1998</li> <li>Mary Julia: 2001</li> <li>John: 2006</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Major companies</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Koch_Industries" class="mw-redirect" title="Koch Industries">Koch Industries</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other organizations</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Americans_for_Prosperity" title="Americans for Prosperity">Americans for Prosperity</a></li> <li><a href="/wiki/Bill_of_Rights_Institute" title="Bill of Rights Institute">Bill of Rights Institute</a></li> <li><a href="/wiki/Cato_Institute" title="Cato Institute">Cato Institute</a></li> <li><a href="/wiki/Charles_Koch_Institute" title="Charles Koch Institute">Charles Koch Institute</a></li> <li><a href="/wiki/Citizens_for_a_Sound_Economy" title="Citizens for a Sound Economy">Citizens for a Sound Economy</a></li> <li><a href="/wiki/Koch_family_foundations" title="Koch family foundations">Koch family foundations</a></li> <li><a class="mw-selflink selflink">Koch Institute for Integrative Cancer Research</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">See also</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Political_activities_of_the_Koch_brothers" class="mw-redirect" title="Political activities of the Koch brothers">Political activities of the Koch brothers</a></li> <li><i><a href="/wiki/Mary_R._Koch" title="Mary R. Koch">Mary R. Koch</a></i> (ship)</li> <li><i><a href="/wiki/The_Science_of_Success" title="The Science of Success">The Science of Success</a></i> (book)</li> <li><i><a href="/wiki/Good_Profit" title="Good Profit">Good Profit</a></i> (book)</li> <li><a href="/wiki/Mercatus_Center" title="Mercatus Center">Mercatus Center</a></li> <li><a href="/wiki/Charles_Koch_Arena" title="Charles Koch Arena">Charles Koch Arena</a></li> <li><a href="/wiki/David_H._Koch_Theater" title="David H. Koch Theater">David H. Koch Theater</a></li> <li><i><a href="/wiki/Koch_Brothers_Exposed" title="Koch Brothers Exposed">Koch Brothers Exposed</a></i></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox authority-control" aria-label="Navbox" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Help:Authority_control" title="Help:Authority control">Authority control databases</a>: National <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q5234534#identifiers" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul><li><span class="uid"><a rel="nofollow" class="external text" href="https://id.loc.gov/authorities/no2020070903">United States</a></span></li></ul></div></td></tr></tbody></table></div> <p><span class="geo-inline-hidden noexcerpt"><style data-mw-deduplicate="TemplateStyles:r1156832818">.mw-parser-output .geo-default,.mw-parser-output .geo-dms,.mw-parser-output .geo-dec{display:inline}.mw-parser-output .geo-nondefault,.mw-parser-output .geo-multi-punct,.mw-parser-output .geo-inline-hidden{display:none}.mw-parser-output .longitude,.mw-parser-output .latitude{white-space:nowrap}</style><span class="plainlinks nourlexpansion"><a class="external text" href="https://geohack.toolforge.org/geohack.php?pagename=Koch_Institute_for_Integrative_Cancer_Research&amp;params=42_21_44_N_71_5_19_W_region:US_type:edu"><span class="geo-default"><span class="geo-dms" title="Maps, aerial photos, and other data for this location"><span class="latitude">42°21′44″N</span> <span class="longitude">71°5′19″W</span></span></span><span class="geo-multi-punct">&#xfeff; / &#xfeff;</span><span class="geo-nondefault"><span class="geo-dec" title="Maps, aerial photos, and other data for this location">42.36222°N 71.08861°W</span><span style="display:none">&#xfeff; / <span class="geo">42.36222; -71.08861</span></span></span></a></span></span> </p> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐5dc468848‐dfr7w Cached time: 20241122151927 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.600 seconds Real time usage: 1.045 seconds Preprocessor visited node count: 2252/1000000 Post‐expand include size: 81278/2097152 bytes Template argument size: 3053/2097152 bytes Highest expansion depth: 15/100 Expensive parser function count: 4/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 90917/5000000 bytes Lua time usage: 0.370/10.000 seconds Lua memory usage: 8951109/52428800 bytes Number of Wikibase entities loaded: 1/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 683.939 1 -total 27.37% 187.162 1 Template:Reflist 17.05% 116.619 9 Template:Cite_web 16.24% 111.068 1 Template:Infobox_research_institute 14.89% 101.828 1 Template:Infobox 14.83% 101.447 1 Template:MITtemplate 14.28% 97.648 2 Template:Navbox 12.16% 83.155 1 Template:Short_description 6.88% 47.080 2 Template:Pagetype 6.55% 44.788 10 Template:Cite_news --> <!-- Saved in parser cache with key enwiki:pcache:idhash:21464432-0!canonical and timestamp 20241122151927 and revision id 1254719991. 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