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Recently, polymorphisms in the promoter region of the interleukin 6 (IL6) gene were shown to be associated with intracranial aneurysmal" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/12929794/Interleukin_6_gene_polymorphisms_are_not_associated_with_aneurysmal_subarachnoid_haemorrhage_in_an_Italian_population" /> <meta property="og:title" content="Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Several lines of evidence indicate a role for inflammatory processes in the development of cerebral aneurysms. Recently, polymorphisms in the promoter region of the interleukin 6 (IL6) gene were shown to be associated with intracranial aneurysmal" /> <meta property="article:author" content="https://unito.academia.edu/SGallone" /> <meta name="description" content="Several lines of evidence indicate a role for inflammatory processes in the development of cerebral aneurysms. Recently, polymorphisms in the promoter region of the interleukin 6 (IL6) gene were shown to be associated with intracranial aneurysmal" /> <meta name="robots" content="noindex" /> <title>Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population | S. Gallone - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/12929794/Interleukin_6_gene_polymorphisms_are_not_associated_with_aneurysmal_subarachnoid_haemorrhage_in_an_Italian_population" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '9387f500ddcbb8d05c67bef28a2fe0334f1aafb8'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732996938000); window.Aedu.timeDifference = new Date().getTime() - 1732996938000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Several lines of evidence indicate a role for inflammatory processes in the development of cerebral aneurysms. Recently, polymorphisms in the promoter region of the interleukin 6 (IL6) gene were shown to be associated with intracranial aneurysmal disease. The purpose of this study was to verify the association of two functionally active polymorphisms (-174 G\u0026amp;amp;amp;amp;amp;amp;amp;gt;C and -572 G\u0026amp;amp;amp;amp;amp;amp;amp;gt;C) in the promoter region of the IL6 gene with the risk and clinical features of aneurysmal subarachnoid haemorrhage (SAH) in an Italian population. A total of 179 consecutive aneurysmal SAH patients and 156 healthy controls were involved in the study. Cases and controls were genotyped for the -174 G\u0026amp;amp;amp;amp;amp;amp;amp;lt;C and the -572 G\u0026amp;amp;amp;amp;amp;amp;amp;lt;C biallelic polymorphisms of the IL6 gene. The frequencies of different promoter haplotypes were compared between cases and controls. Allelic and genotypic frequencies of the examined polymorphism were not significantly different between cases and controls. Inferred haplotypes were not significantly different in both groups. Finally, the different IL6 genotypes did not seem to significantly modify the main clinical features of the disease. Our study did not confirm the association between functionally active polymorphisms in the IL6 gene and the risk of aneurysmal SAH in an Italian population. Additional studies in different populations are warranted to clarify the role of the IL6 gene in the pathogenesis of aneurysmal SAH.","author":[{"@context":"https://schema.org","@type":"Person","name":"S. Gallone"}],"contributor":[],"dateCreated":"2015-06-11","dateModified":"2023-10-22","datePublished":"2008-01-01","headline":"Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population","inLanguage":"en","keywords":["Population Genetics","Italy","Humans","Haplotypes","Female","Male","Subarachnoid hemorrhage","Risk factors","Aged","Middle Aged","Gene Polymorphism","Genotype","Adult","Risk Factors","Subarachnoid haemorrhage","Interleukin"],"locationCreated":null,"publication":"Journal of Neurology, Neurosurgery \u0026 Psychiatry","publisher":{"@context":"https://schema.org","@type":"Organization","name":"BMJ"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/12929794/Interleukin_6_gene_polymorphisms_are_not_associated_with_aneurysmal_subarachnoid_haemorrhage_in_an_Italian_population","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"unito"}]}</script><link 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F12929794%2FInterleukin_6_gene_polymorphisms_are_not_associated_with_aneurysmal_subarachnoid_haemorrhage_in_an_Italian_population%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F12929794%2FInterleukin_6_gene_polymorphisms_are_not_associated_with_aneurysmal_subarachnoid_haemorrhage_in_an_Italian_population%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = []; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":12929794,"created_at":"2015-06-11T09:21:00.907-07:00","from_world_paper_id":137525721,"updated_at":"2021-01-18T03:04:28.416-08:00","_data":{"abstract":"Several lines of evidence indicate a role for inflammatory processes in the development of cerebral aneurysms. Recently, polymorphisms in the promoter region of the interleukin 6 (IL6) gene were shown to be associated with intracranial aneurysmal disease. The purpose of this study was to verify the association of two functionally active polymorphisms (-174 G\u0026amp;gt;C and -572 G\u0026amp;gt;C) in the promoter region of the IL6 gene with the risk and clinical features of aneurysmal subarachnoid haemorrhage (SAH) in an Italian population. A total of 179 consecutive aneurysmal SAH patients and 156 healthy controls were involved in the study. Cases and controls were genotyped for the -174 G\u0026amp;lt;C and the -572 G\u0026amp;lt;C biallelic polymorphisms of the IL6 gene. The frequencies of different promoter haplotypes were compared between cases and controls. Allelic and genotypic frequencies of the examined polymorphism were not significantly different between cases and controls. Inferred haplotypes were not significantly different in both groups. Finally, the different IL6 genotypes did not seem to significantly modify the main clinical features of the disease. Our study did not confirm the association between functionally active polymorphisms in the IL6 gene and the risk of aneurysmal SAH in an Italian population. Additional studies in different populations are warranted to clarify the role of the IL6 gene in the pathogenesis of aneurysmal SAH.","publication_date":"2008,,","publication_name":"Journal of Neurology, Neurosurgery \u0026 Psychiatry"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"low","language":"en","title":"Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population","broadcastable":false,"draft":null,"has_indexable_attachment":false,"indexable":true}}["work"]; window.loswp.workCoauthors = [32102494]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "grid"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="loswp-grid--container"><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-landing_url="https://www.academia.edu/12929794/Interleukin_6_gene_polymorphisms_are_not_associated_with_aneurysmal_subarachnoid_haemorrhage_in_an_Italian_population" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="above-fold js-swp-splash-above-fold"><div class="work-card--container js-swp-control-work-card" data-entity-id="12929794"><div class="work-cover--wrapper"><div class="work-cover--container"><div class="work-cover--no-attachment-container js-swp-splash-paper-cover"><div class="work-cover--file-icon-wrapper"><img alt="paper cover icon" src="//a.academia-assets.com/images/single_work_splash/adobe.icon.svg" /></div><div class="work-cover--title js-swp-splash-paper-cover-page-title">Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population</div><br /><div style="margin-top: 170px"><button class="work-cover--request-pdf-button js-request-pdf-button"><svg style="width: 14px; margin-right: 8px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="envelope" class="svg-inline--fa fa-envelope fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V195.6c0-5 5.7-7.8 9.7-4.7 22.4 17.4 52.1 39.5 154.1 113.6 21.1 15.4 56.7 47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z"></path></svg>Request PDF</button></div></div></div></div><div class="work-card--content"><h1 class="work-card--title">Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population</h1><div class="work-card--pub-info">Journal of Neurology, Neurosurgery & Psychiatry, 2008</div><div class="work-card--authors-container js-work-toolbar-work-owner"><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><a href="https://unito.academia.edu/SGallone"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></a></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><a class="u-linkUnstyled u-fw500 u-textTruncate ds2-5-body-sm ds2-5-body-link" href="https://unito.academia.edu/SGallone" swp="tc-au-12929794">S. Gallone</a></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">Marco Fontanella</div></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">Alessandro Ducati</div></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">Innocenzo Rainero</div></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">L. Pinessi</div></div></div><div class="work-card--author-blurb"><div class="work-card--author-photo-wrapper"><img class="Avatar--circle s65 Avatar--xxxs" shape="circle" border="0" alt="" src="//a.academia-assets.com/images/s65_no_pic.png" /></div><div class="work-card--author-name-wrapper" style="max-width: 125px;"><div class="u-fontStyleItalic u-textTruncate">Salvatore Rubino</div></div></div></div><div class="work-card--no-attachment-details"><div style="font-weight: 700; font-size: 14px;">Abstract</div><div class="work-card--abstract js-swp-splash-abstract">Several lines of evidence indicate a role for inflammatory processes in the development of cerebral aneurysms. Recently, polymorphisms in the promoter region of the interleukin 6 (IL6) gene were shown to be associated with intracranial aneurysmal disease. The purpose of this study was to verify the association of two functionally active polymorphisms (-174 G&amp;gt;C and -572 G&amp;gt;C) in the promoter region of the IL6 gene with the risk and clinical features of aneurysmal subarachnoid haemorrhage (SAH) in an Italian population. A total of 179 consecutive aneurysmal SAH patients and 156 healthy controls were involved in the study. Cases and controls were genotyped for the -174 G&amp;lt;C and the -572 G&amp;lt;C biallelic polymorphisms of the IL6 gene. The frequencies of different promoter haplotypes were compared between cases and controls. Allelic and genotypic frequencies of the examined polymorphism were not significantly different between cases and controls. Inferred haplotypes were not significantly different in both groups. Finally, the different IL6 genotypes did not seem to significantly modify the main clinical features of the disease. Our study did not confirm the association between functionally active polymorphisms in the IL6 gene and the risk of aneurysmal SAH in an Italian population. Additional studies in different populations are warranted to clarify the role of the IL6 gene in the pathogenesis of aneurysmal SAH.</div></div><div class="request-upload--container"><p class="request-upload--title">S. 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