Search | arXiv e-print repository

<!DOCTYPE html> <html lang="en"> <head> <meta charset="utf-8"/> <meta name="viewport" content="width=device-width, initial-scale=1"/>  <link rel="apple-touch-icon" sizes="180x180" href="https://static.arxiv.org/static/base/1.0.0a5/images/icons/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://static.arxiv.org/static/base/1.0.0a5/images/icons/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://static.arxiv.org/static/base/1.0.0a5/images/icons/favicon-16x16.png"> <link rel="manifest" href="https://static.arxiv.org/static/base/1.0.0a5/images/icons/site.webmanifest"> <link rel="mask-icon" href="https://static.arxiv.org/static/base/1.0.0a5/images/icons/safari-pinned-tab.svg" color="#b31b1b"> <link rel="shortcut icon" href="https://static.arxiv.org/static/base/1.0.0a5/images/icons/favicon.ico"> <meta name="msapplication-TileColor" content="#b31b1b"> <meta name="msapplication-config" content="images/icons/browserconfig.xml"> <meta name="theme-color" content="#b31b1b">  <title>Search | arXiv e-print repository</title> <script defer src="https://static.arxiv.org/static/base/1.0.0a5/fontawesome-free-5.11.2-web/js/all.js"></script> <link rel="stylesheet" href="https://static.arxiv.org/static/base/1.0.0a5/css/arxivstyle.css" /> <script type="text/x-mathjax-config"> MathJax.Hub.Config({ messageStyle: "none", extensions: ["tex2jax.js"], jax: ["input/TeX", "output/HTML-CSS"], tex2jax: { inlineMath: [ ['$','$'], ["\$","\$"] ], displayMath: [ ['$$','$$'], ["\\[","\\]"] ], processEscapes: true, ignoreClass: '.*', processClass: 'mathjax.*' }, TeX: { extensions: ["AMSmath.js", "AMSsymbols.js", "noErrors.js"], noErrors: { inlineDelimiters: ["$","$"], multiLine: false, style: { "font-size": "normal", "border": "" } } }, "HTML-CSS": { availableFonts: ["TeX"] } }); </script> <script src='//static.arxiv.org/MathJax-2.7.3/MathJax.js'></script> <script src="https://static.arxiv.org/static/base/1.0.0a5/js/notification.js"></script> <link rel="stylesheet" href="https://static.arxiv.org/static/search/0.5.6/css/bulma-tooltip.min.css" /> <link rel="stylesheet" href="https://static.arxiv.org/static/search/0.5.6/css/search.css" /> <script src="https://code.jquery.com/jquery-3.2.1.slim.min.js" integrity="sha256-k2WSCIexGzOj3Euiig+TlR8gA0EmPjuc79OEeY5L45g=" crossorigin="anonymous"></script> <script src="https://static.arxiv.org/static/search/0.5.6/js/fieldset.js"></script> <style> radio#cf-customfield_11400 { display: none; } </style> </head> <body> <header><a href="#main-container" class="is-sr-only">Skip to main content</a>  <div class="attribution level is-marginless" role="banner"> <div class="level-left"> <a class="level-item" href="https://cornell.edu/"><img src="https://static.arxiv.org/static/base/1.0.0a5/images/cornell-reduced-white-SMALL.svg" alt="Cornell University" width="200" aria-label="logo" /></a> </div> <div class="level-right is-marginless"><p class="sponsors level-item is-marginless"><span id="support-ack-url">We gratefully acknowledge support from<br /> the Simons Foundation, <a href="https://info.arxiv.org/about/ourmembers.html">member institutions</a>, and all contributors. <a href="https://info.arxiv.org/about/donate.html">Donate</a></span></p></div> </div>  <div class="identity level is-marginless"> <div class="level-left"> <div class="level-item"> <a class="arxiv" href="https://arxiv.org/" aria-label="arxiv-logo"> <img src="https://static.arxiv.org/static/base/1.0.0a5/images/arxiv-logo-one-color-white.svg" aria-label="logo" alt="arxiv logo" width="85" style="width:85px;"/> </a> </div> </div> <div class="search-block level-right"> <form class="level-item mini-search" method="GET" action="https://arxiv.org/search"> <div class="field has-addons"> <div class="control"> <input class="input is-small" type="text" name="query" placeholder="Search..." aria-label="Search term or terms" /> <p class="help"><a href="https://info.arxiv.org/help">Help</a> | <a href="https://arxiv.org/search/advanced">Advanced Search</a></p> </div> <div class="control"> <div class="select is-small"> <select name="searchtype" aria-label="Field to search"> <option value="all" selected="selected">All fields</option> <option value="title">Title</option> <option value="author">Author</option> <option value="abstract">Abstract</option> <option value="comments">Comments</option> <option value="journal_ref">Journal reference</option> <option value="acm_class">ACM classification</option> <option value="msc_class">MSC classification</option> <option value="report_num">Report number</option> <option value="paper_id">arXiv identifier</option> <option value="doi">DOI</option> <option value="orcid">ORCID</option> <option value="author_id">arXiv author ID</option> <option value="help">Help pages</option> <option value="full_text">Full text</option> </select> </div> </div> <input type="hidden" name="source" value="header"> <button class="button is-small is-cul-darker">Search</button> </div> </form> </div> </div>  <div class="container"> <div class="user-tools is-size-7 has-text-right has-text-weight-bold" role="navigation" aria-label="User menu"> <a href="https://arxiv.org/login">Login</a> </div> </div> </header> <main class="container" id="main-container"> <div class="level is-marginless"> <div class="level-left"> <h1 class="title is-clearfix"> Showing 1–2 of 2 results for author: <span class="mathjax">Trifan, A</span> </h1> </div> <div class="level-right is-hidden-mobile">  <span class="help" style="display: inline-block;"><a href="https://github.com/arXiv/arxiv-search/releases">Search v0.5.6 released 2020-02-24</a>  </span> </div> </div> <div class="content"> <form method="GET" action="/search/q-bio" aria-role="search"> Searching in archive <strong>q-bio</strong>. <a href="/search/?searchtype=author&query=Trifan%2C+A">Search in all archives.</a> <div class="field has-addons-tablet"> <div class="control is-expanded"> <label for="query" class="hidden-label">Search term or terms</label> <input class="input is-medium" id="query" name="query" placeholder="Search term..." type="text" value="Trifan, A"> </div> <div class="select control is-medium"> <label class="is-hidden" for="searchtype">Field</label> <select class="is-medium" id="searchtype" name="searchtype"><option value="all">All fields</option><option value="title">Title</option><option selected value="author">Author(s)</option><option value="abstract">Abstract</option><option value="comments">Comments</option><option value="journal_ref">Journal reference</option><option value="acm_class">ACM classification</option><option value="msc_class">MSC classification</option><option value="report_num">Report number</option><option value="paper_id">arXiv identifier</option><option value="doi">DOI</option><option value="orcid">ORCID</option><option value="license">License (URI)</option><option value="author_id">arXiv author ID</option><option value="help">Help pages</option><option value="full_text">Full text</option></select> </div> <div class="control"> <button class="button is-link is-medium">Search</button> </div> </div> <div class="field"> <div class="control is-size-7"> <label class="radio"> <input checked id="abstracts-0" name="abstracts" type="radio" value="show"> Show abstracts </label> <label class="radio"> <input id="abstracts-1" name="abstracts" type="radio" value="hide"> Hide abstracts </label> </div> </div> <div class="is-clearfix" style="height: 2.5em"> <div class="is-pulled-right"> <a href="/search/advanced?terms-0-term=Trifan%2C+A&terms-0-field=author&size=50&order=-announced_date_first">Advanced Search</a> </div> </div> <input type="hidden" name="order" value="-announced_date_first"> <input type="hidden" name="size" value="50"> </form> <div class="level breathe-horizontal"> <div class="level-left"> <form method="GET" action="/search/"> <div style="display: none;"> <select id="searchtype" name="searchtype"><option value="all">All fields</option><option value="title">Title</option><option selected value="author">Author(s)</option><option value="abstract">Abstract</option><option value="comments">Comments</option><option value="journal_ref">Journal reference</option><option value="acm_class">ACM classification</option><option value="msc_class">MSC classification</option><option value="report_num">Report number</option><option value="paper_id">arXiv identifier</option><option value="doi">DOI</option><option value="orcid">ORCID</option><option value="license">License (URI)</option><option value="author_id">arXiv author ID</option><option value="help">Help pages</option><option value="full_text">Full text</option></select> <input id="query" name="query" type="text" value="Trifan, A"> <ul id="abstracts"><li><input checked id="abstracts-0" name="abstracts" type="radio" value="show"> <label for="abstracts-0">Show abstracts</label></li><li><input id="abstracts-1" name="abstracts" type="radio" value="hide"> <label for="abstracts-1">Hide abstracts</label></li></ul> </div> <div class="box field is-grouped is-grouped-multiline level-item"> <div class="control"> <span class="select is-small"> <select id="size" name="size"><option value="25">25</option><option selected value="50">50</option><option value="100">100</option><option value="200">200</option></select> </span> <label for="size">results per page</label>. </div> <div class="control"> <label for="order">Sort results by</label> <span class="select is-small"> <select id="order" name="order"><option selected value="-announced_date_first">Announcement date (newest first)</option><option value="announced_date_first">Announcement date (oldest first)</option><option value="-submitted_date">Submission date (newest first)</option><option value="submitted_date">Submission date (oldest first)</option><option value="">Relevance</option></select> </span> </div> <div class="control"> <button class="button is-small is-link">Go</button> </div> </div> </form> </div> </div> <ol class="breathe-horizontal" start="1"> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/2103.02843">arXiv:2103.02843</a> <span> [<a href="https://arxiv.org/pdf/2103.02843">pdf</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Distributed, Parallel, and Cluster Computing">cs.DC</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Computational Engineering, Finance, and Science">cs.CE</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Machine Learning">cs.LG</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Biological Physics">physics.bio-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Quantitative Methods">q-bio.QM</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1098/rsfs.2021.0018">10.1098/rsfs.2021.0018 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Pandemic Drugs at Pandemic Speed: Infrastructure for Accelerating COVID-19 Drug Discovery with Hybrid Machine Learning- and Physics-based Simulations on High Performance Computers </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/q-bio?searchtype=author&query=Bhati%2C+A+P">Agastya P. Bhati</a>, <a href="/search/q-bio?searchtype=author&query=Wan%2C+S">Shunzhou Wan</a>, <a href="/search/q-bio?searchtype=author&query=Alf%C3%A8%2C+D">Dario Alf猫</a>, <a href="/search/q-bio?searchtype=author&query=Clyde%2C+A+R">Austin R. Clyde</a>, <a href="/search/q-bio?searchtype=author&query=Bode%2C+M">Mathis Bode</a>, <a href="/search/q-bio?searchtype=author&query=Tan%2C+L">Li Tan</a>, <a href="/search/q-bio?searchtype=author&query=Titov%2C+M">Mikhail Titov</a>, <a href="/search/q-bio?searchtype=author&query=Merzky%2C+A">Andre Merzky</a>, <a href="/search/q-bio?searchtype=author&query=Turilli%2C+M">Matteo Turilli</a>, <a href="/search/q-bio?searchtype=author&query=Jha%2C+S">Shantenu Jha</a>, <a href="/search/q-bio?searchtype=author&query=Highfield%2C+R+R">Roger R. Highfield</a>, <a href="/search/q-bio?searchtype=author&query=Rocchia%2C+W">Walter Rocchia</a>, <a href="/search/q-bio?searchtype=author&query=Scafuri%2C+N">Nicola Scafuri</a>, <a href="/search/q-bio?searchtype=author&query=Succi%2C+S">Sauro Succi</a>, <a href="/search/q-bio?searchtype=author&query=Kranzlm%C3%BCller%2C+D">Dieter Kranzlm眉ller</a>, <a href="/search/q-bio?searchtype=author&query=Mathias%2C+G">Gerald Mathias</a>, <a href="/search/q-bio?searchtype=author&query=Wifling%2C+D">David Wifling</a>, <a href="/search/q-bio?searchtype=author&query=Donon%2C+Y">Yann Donon</a>, <a href="/search/q-bio?searchtype=author&query=Di+Meglio%2C+A">Alberto Di Meglio</a>, <a href="/search/q-bio?searchtype=author&query=Vallecorsa%2C+S">Sofia Vallecorsa</a>, <a href="/search/q-bio?searchtype=author&query=Ma%2C+H">Heng Ma</a>, <a href="/search/q-bio?searchtype=author&query=Trifan%2C+A">Anda Trifan</a>, <a href="/search/q-bio?searchtype=author&query=Ramanathan%2C+A">Arvind Ramanathan</a>, <a href="/search/q-bio?searchtype=author&query=Brettin%2C+T">Tom Brettin</a>, <a href="/search/q-bio?searchtype=author&query=Partin%2C+A">Alexander Partin</a> , et al. (4 additional authors not shown) </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="2103.02843v2-abstract-short" style="display: inline;"> The race to meet the challenges of the global pandemic has served as a reminder that the existing drug discovery process is expensive, inefficient and slow. There is a major bottleneck screening the vast number of potential small molecules to shortlist lead compounds for antiviral drug development. New opportunities to accelerate drug discovery lie at the interface between machine learning methods… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2103.02843v2-abstract-full').style.display = 'inline'; document.getElementById('2103.02843v2-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="2103.02843v2-abstract-full" style="display: none;"> The race to meet the challenges of the global pandemic has served as a reminder that the existing drug discovery process is expensive, inefficient and slow. There is a major bottleneck screening the vast number of potential small molecules to shortlist lead compounds for antiviral drug development. New opportunities to accelerate drug discovery lie at the interface between machine learning methods, in this case developed for linear accelerators, and physics-based methods. The two in silico methods, each have their own advantages and limitations which, interestingly, complement each other. Here, we present an innovative infrastructural development that combines both approaches to accelerate drug discovery. The scale of the potential resulting workflow is such that it is dependent on supercomputing to achieve extremely high throughput. We have demonstrated the viability of this workflow for the study of inhibitors for four COVID-19 target proteins and our ability to perform the required large-scale calculations to identify lead antiviral compounds through repurposing on a variety of supercomputers. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2103.02843v2-abstract-full').style.display = 'none'; document.getElementById('2103.02843v2-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 4 September, 2021; <span class="has-text-black-bis has-text-weight-semibold">v1</span> submitted 4 March, 2021; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> March 2021. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Journal ref:</span> Interface Focus. 2021. 11 (6): 20210018 </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/2010.06574">arXiv:2010.06574</a> <span> [<a href="https://arxiv.org/pdf/2010.06574">pdf</a>, <a href="https://arxiv.org/format/2010.06574">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Distributed, Parallel, and Cluster Computing">cs.DC</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Computational Engineering, Finance, and Science">cs.CE</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Quantitative Methods">q-bio.QM</span> </div> </div> <p class="title is-5 mathjax"> IMPECCABLE: Integrated Modeling PipelinE for COVID Cure by Assessing Better LEads </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/q-bio?searchtype=author&query=Saadi%2C+A+A">Aymen Al Saadi</a>, <a href="/search/q-bio?searchtype=author&query=Alfe%2C+D">Dario Alfe</a>, <a href="/search/q-bio?searchtype=author&query=Babuji%2C+Y">Yadu Babuji</a>, <a href="/search/q-bio?searchtype=author&query=Bhati%2C+A">Agastya Bhati</a>, <a href="/search/q-bio?searchtype=author&query=Blaiszik%2C+B">Ben Blaiszik</a>, <a href="/search/q-bio?searchtype=author&query=Brettin%2C+T">Thomas Brettin</a>, <a href="/search/q-bio?searchtype=author&query=Chard%2C+K">Kyle Chard</a>, <a href="/search/q-bio?searchtype=author&query=Chard%2C+R">Ryan Chard</a>, <a href="/search/q-bio?searchtype=author&query=Coveney%2C+P">Peter Coveney</a>, <a href="/search/q-bio?searchtype=author&query=Trifan%2C+A">Anda Trifan</a>, <a href="/search/q-bio?searchtype=author&query=Brace%2C+A">Alex Brace</a>, <a href="/search/q-bio?searchtype=author&query=Clyde%2C+A">Austin Clyde</a>, <a href="/search/q-bio?searchtype=author&query=Foster%2C+I">Ian Foster</a>, <a href="/search/q-bio?searchtype=author&query=Gibbs%2C+T">Tom Gibbs</a>, <a href="/search/q-bio?searchtype=author&query=Jha%2C+S">Shantenu Jha</a>, <a href="/search/q-bio?searchtype=author&query=Keipert%2C+K">Kristopher Keipert</a>, <a href="/search/q-bio?searchtype=author&query=Kurth%2C+T">Thorsten Kurth</a>, <a href="/search/q-bio?searchtype=author&query=Kranzlm%C3%BCller%2C+D">Dieter Kranzlm眉ller</a>, <a href="/search/q-bio?searchtype=author&query=Lee%2C+H">Hyungro Lee</a>, <a href="/search/q-bio?searchtype=author&query=Li%2C+Z">Zhuozhao Li</a>, <a href="/search/q-bio?searchtype=author&query=Ma%2C+H">Heng Ma</a>, <a href="/search/q-bio?searchtype=author&query=Merzky%2C+A">Andre Merzky</a>, <a href="/search/q-bio?searchtype=author&query=Mathias%2C+G">Gerald Mathias</a>, <a href="/search/q-bio?searchtype=author&query=Partin%2C+A">Alexander Partin</a>, <a href="/search/q-bio?searchtype=author&query=Yin%2C+J">Junqi Yin</a> , et al. (11 additional authors not shown) </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="2010.06574v1-abstract-short" style="display: inline;"> The drug discovery process currently employed in the pharmaceutical industry typically requires about 10 years and $2-3 billion to deliver one new drug. This is both too expensive and too slow, especially in emergencies like the COVID-19 pandemic. In silicomethodologies need to be improved to better select lead compounds that can proceed to later stages of the drug discovery protocol accelerating… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2010.06574v1-abstract-full').style.display = 'inline'; document.getElementById('2010.06574v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="2010.06574v1-abstract-full" style="display: none;"> The drug discovery process currently employed in the pharmaceutical industry typically requires about 10 years and $2-3 billion to deliver one new drug. This is both too expensive and too slow, especially in emergencies like the COVID-19 pandemic. In silicomethodologies need to be improved to better select lead compounds that can proceed to later stages of the drug discovery protocol accelerating the entire process. No single methodological approach can achieve the necessary accuracy with required efficiency. Here we describe multiple algorithmic innovations to overcome this fundamental limitation, development and deployment of computational infrastructure at scale integrates multiple artificial intelligence and simulation-based approaches. Three measures of performance are:(i) throughput, the number of ligands per unit time; (ii) scientific performance, the number of effective ligands sampled per unit time and (iii) peak performance, in flop/s. The capabilities outlined here have been used in production for several months as the workhorse of the computational infrastructure to support the capabilities of the US-DOE National Virtual Biotechnology Laboratory in combination with resources from the EU Centre of Excellence in Computational Biomedicine. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2010.06574v1-abstract-full').style.display = 'none'; document.getElementById('2010.06574v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 13 October, 2020; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> October 2020. </p> </li> </ol> <div class="is-hidden-tablet">  <span class="help" style="display: inline-block;"><a href="https://github.com/arXiv/arxiv-search/releases">Search v0.5.6 released 2020-02-24</a>  </span> </div> </div> </main> <footer> <div class="columns is-desktop" role="navigation" aria-label="Secondary">  <div class="column"> <div class="columns"> <div class="column"> <ul class="nav-spaced"> <li><a href="https://info.arxiv.org/about">About</a></li> <li><a href="https://info.arxiv.org/help">Help</a></li> </ul> </div> <div class="column"> <ul class="nav-spaced"> <li> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" class="icon filter-black" role="presentation"><title>contact arXiv</title><desc>Click here to contact arXiv</desc><path d="M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V195.6c0-5 5.7-7.8 9.7-4.7 22.4 17.4 52.1 39.5 154.1 113.6 21.1 15.4 56.7 47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z"/></svg> <a href="https://info.arxiv.org/help/contact.html"> Contact</a> </li> <li> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" class="icon filter-black" role="presentation"><title>subscribe to arXiv mailings</title><desc>Click here to subscribe</desc><path d="M476 3.2L12.5 270.6c-18.1 10.4-15.8 35.6 2.2 43.2L121 358.4l287.3-253.2c5.5-4.9 13.3 2.6 8.6 8.3L176 407v80.5c0 23.6 28.5 32.9 42.5 15.8L282 426l124.6 52.2c14.2 6 30.4-2.9 33-18.2l72-432C515 7.8 493.3-6.8 476 3.2z"/></svg> <a href="https://info.arxiv.org/help/subscribe"> Subscribe</a> </li> </ul> </div> </div> </div>   <div class="column"> <div class="columns"> <div class="column"> <ul class="nav-spaced"> <li><a href="https://info.arxiv.org/help/license/index.html">Copyright</a></li> <li><a href="https://info.arxiv.org/help/policies/privacy_policy.html">Privacy Policy</a></li> </ul> </div> <div class="column sorry-app-links"> <ul class="nav-spaced"> <li><a href="https://info.arxiv.org/help/web_accessibility.html">Web Accessibility Assistance</a></li> <li> <p class="help"> <a class="a11y-main-link" href="https://status.arxiv.org" target="_blank">arXiv Operational Status <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 256 512" class="icon filter-dark_grey" role="presentation"><path d="M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z"/></svg></a><br> Get status notifications via <a class="is-link" href="https://subscribe.sorryapp.com/24846f03/email/new" target="_blank"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" class="icon filter-black" role="presentation"><path d="M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V195.6c0-5 5.7-7.8 9.7-4.7 22.4 17.4 52.1 39.5 154.1 113.6 21.1 15.4 56.7 47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z"/></svg>email</a> or <a class="is-link" href="https://subscribe.sorryapp.com/24846f03/slack/new" target="_blank"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" class="icon filter-black" role="presentation"><path d="M94.12 315.1c0 25.9-21.16 47.06-47.06 47.06S0 341 0 315.1c0-25.9 21.16-47.06 47.06-47.06h47.06v47.06zm23.72 0c0-25.9 21.16-47.06 47.06-47.06s47.06 21.16 47.06 47.06v117.84c0 25.9-21.16 47.06-47.06 47.06s-47.06-21.16-47.06-47.06V315.1zm47.06-188.98c-25.9 0-47.06-21.16-47.06-47.06S139 32 164.9 32s47.06 21.16 47.06 47.06v47.06H164.9zm0 23.72c25.9 0 47.06 21.16 47.06 47.06s-21.16 47.06-47.06 47.06H47.06C21.16 243.96 0 222.8 0 196.9s21.16-47.06 47.06-47.06H164.9zm188.98 47.06c0-25.9 21.16-47.06 47.06-47.06 25.9 0 47.06 21.16 47.06 47.06s-21.16 47.06-47.06 47.06h-47.06V196.9zm-23.72 0c0 25.9-21.16 47.06-47.06 47.06-25.9 0-47.06-21.16-47.06-47.06V79.06c0-25.9 21.16-47.06 47.06-47.06 25.9 0 47.06 21.16 47.06 47.06V196.9zM283.1 385.88c25.9 0 47.06 21.16 47.06 47.06 0 25.9-21.16 47.06-47.06 47.06-25.9 0-47.06-21.16-47.06-47.06v-47.06h47.06zm0-23.72c-25.9 0-47.06-21.16-47.06-47.06 0-25.9 21.16-47.06 47.06-47.06h117.84c25.9 0 47.06 21.16 47.06 47.06 0 25.9-21.16 47.06-47.06 47.06H283.1z"/></svg>slack</a> </p> </li> </ul> </div> </div> </div>  </div> </footer> <script src="https://static.arxiv.org/static/base/1.0.0a5/js/member_acknowledgement.js"></script> </body> </html>

CINXE.COM

Search | arXiv e-print repository