片剂溶出度相关知识汇总, 康强医药网

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片剂溶出度相关知识汇总 </h1> <div class="text" style="float: left; margin-top: 25px; margin-bottom: 5px; width: 680px;"> <span style="float: left; color: #999999;"> 2019-05-16   <span>作者：</span><span style="color: #999999">制药质量、研发、注册交流 </span>    <span>来源: </span><span style="color: #999999">搜狗微信</span>   <span>访问量:</span><span style="color: #999999; font-size: 14px;" id="viewvisit">313</span> <span>次</span>   <span><a onclick="addNews();" target="_blank" style="cursor: pointer; color: #3e71a6;">在线投稿</a></span> </span><span style="float: right; margin-right: 50px;"> <div class="bdsharebuttonbox"> <a href="#" class="bds_more" data-cmd="more">分享到：</a> <a href="#" class="bds_weixin" data-cmd="weixin" title="分享到微信"></a><a href="#" class="bds_qzone" data-cmd="qzone" title="分享到QQ空间"></a><a href="#" class="bds_tsina" data-cmd="tsina" title="分享到新浪微博"></a><a href="#" class="bds_tqq" data-cmd="tqq" title="分享到腾讯微博"></a> </div> </span> </div> <div style="float: left; width: 620px;"> <div style="clear: both;"> </div> </div> </div> </div> <div id="endText" style="width: 630px; margin: 5px 50px 0 50px;"> <div id="xgnews" style="background: #F2F2F2; margin: 5px 55px 5px 5px;"> <div style="line-height: 25px; font-size: 16px; text-indent: 2em;"> 【导读】上述分类可以作为设定体外溶出度质量标准的依据，也可用于预测能否建立良好的体内-体外相关性的依据。BSC提示，对于高溶解度、高渗透性（1类）药物及某些情况下的高溶解度、低渗透性（3类）药物，其溶出度在0.1NHCL中15min时为85%即可保证药物的生物利用度不受溶出的限制，即制剂的行为与溶液相似。 </div> </div> <div style="max-width: 100% !important; overflow-x: auto; text-align: center; font-size: 18px;" id="pic1"><p style="text-align:justify;"> <br /> </p> <p style="text-align:justify;"> <br /> </p> <p> <br /> </p> <p style="text-align:justify;32px;"> <span style="font-size:16px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">溶出度</span></strong></span><span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">（Dissolution rate）也称溶出速率，是指在规定的溶剂和条件下，药物从片剂、胶囊剂、颗粒剂等固体制剂中溶出的速度和程度。测定固体制剂溶出度的过程称为溶出度试验（Dissolution test），它是一种模拟口服固体制剂在胃肠道中的崩解和溶出的体外试验方法。药物溶出度检查是评价制剂品质和工艺水平的一种有效手段，可以在一定程度上反映主药的晶型、粒度、处方组成、辅料品种和性质、生产工艺等的差异；在产品发生某些变更后（如处方、生产工艺、生产场所变更和生产工艺放大），确认药品质量和疗效的一致性；也是评价制剂活性成分生物利用度和制剂均匀度</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">的一种有效标准，能有效区分同一种药物生物利用度的差异，因此是药品质量控制必检项目之一。</span></span> </p> <p style="text-align:justify;32px;"> <br /> </p> <p style="text-align:justify;32px;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">一般认为，难溶性</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">（一般指在水中微溶或不溶）</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">药物，因制剂处方与生产工艺造成临床疗效不稳定的药物以及治疗量与中毒量相接近的药物（包括易溶性药物），其口服固体制剂质量标准中必须设定溶出度检查项。另外固体制剂的处方筛选及生产工艺流程制订过程中，也需对所开发剂型的溶出度做全面考察。一个可行的溶出度试验法应是在不同时间、地点对同一制剂的溶出度测定或不同的操作者之间的测定都必须达到试验结果具有良好的重现性。为了达到以上目的，必须对溶出度测定试验进行</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">全面充分的研究。</span></span> </p> <p style="text-align:justify;"> <br /> </p> <p style="text-align:justify;32px;"> <span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">生物药剂学（</span></strong><strong><span style="line-height:21px;font-size:16px;">BCS</span></strong><strong><span style="line-height:21px;font-size:16px;">）分类（美国</span></strong><strong><span style="line-height:21px;font-size:16px;">FDA </span></strong><strong><span style="line-height:21px;font-size:16px;">）：</span></strong></span> </p> <p style="text-align:justify;32px;"> <span style="line-height:21px;font-size:16px;">第1类：高溶解度一高渗透性</span> </p> <p style="text-align:justify;32px;"> <span style="line-height:21px;font-size:16px;">第2类：低溶解度一高渗透性</span> </p> <p style="text-align:justify;32px;"> <span style="line-height:21px;font-size:16px;">第3类：高溶解度一低渗透性</span> </p> <p style="text-align:justify;32px;"> <span style="line-height:21px;font-size:16px;">第4类：低溶解度一低渗透性</span> </p> <p style="text-align:justify;32px;"> <br /> </p> <p style="text-align:justify;32px;"> <span style="line-height:21px;font-size:16px;">高溶解度：单个制剂能在250mL，pH值1.0～8.0介质中溶解</span><strong><span style="line-height:21px;font-size:16px;">——</span></strong><span style="line-height:21px;font-size:16px;">相当于中国药典的</span><strong><span style="line-height:21px;font-size:16px;">“</span></strong><span style="line-height:21px;font-size:16px;">微溶</span><strong><span style="line-height:21px;font-size:16px;">”</span></strong> </p> <p style="text-align:justify;32px;"> <br /> </p> <p style="text-align:justify;32px;"> <span style="line-height:21px;font-size:16px;">高渗透性：******生物利用度≥90%</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">上述分类可以作为设定体外溶出度质量标准的依据，也可用于预测能否建立良好的体内-体外相关性的依据。BSC提示，对于高溶解度、高渗透性（1类）药物及某些情况下的高溶解度、低渗透性（3类）药物，其溶出度在0.1NHCL中15min时为85%即可保证药物的生物利用度不受溶出的限制，即制剂的行为与溶液相似。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="line-height:21px;color:#0070C0;font-size:16px;">溶出度研究试验主要包括以下内容：</span><span style="line-height:21px;font-size:16px;">（1）溶出介质的选择，（2）</span><span style="line-height:28px;"> </span><span style="line-height:21px;font-size:16px;">溶出介质体积的选择，（3）溶出方法（转篮法与桨法）的选择，（4）转速的选择，（5）溶出度测定方法的验证，（6）</span><span style="line-height:28px;"> </span><span style="line-height:21px;font-size:16px;">溶出度均一性试验（批内），（7）重现性试验（批间）等。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:14px;line-height:21px;"><span style="font-size:16px;">   </span><br /> <span style="font-size:16px;">    近来在新药审评中发现，部分研究单位在进行溶出度研究时存在一些问题，主要表现在溶出度研究资料过于简单或溶出度研究内容不够全面。现予以具体分析，希望能对溶出度研究有一定的帮助。</span></span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="font-size:14px;line-height:21px;"> </span><span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">1</span></strong><strong><span style="line-height:21px;font-size:16px;">、溶出介质的选择：</span></strong></span><span style="color:#00B0F0;font-size:16px;"><span style="font-size:16px;line-height:21px;"> </span></span> </p> <p style="text-align:justify;"> <span style="color:#00B0F0;font-size:16px;"><span style="font-size:16px;line-height:21px;"><br /> </span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="font-size:14px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">介质种类</span></strong><strong><span style="line-height:21px;font-size:16px;">:</span></strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;18px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">水</span><strong><span style="line-height:21px;font-size:16px;">——</span></strong><span style="line-height:21px;font-size:16px;">*常用，良好脱气水的pH值为5.0～7.0,</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">适用于溶解度对pH值不敏感的药物</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;18px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;24px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">盐酸溶液</span><strong><span style="line-height:21px;font-size:16px;">——</span></strong><span style="line-height:21px;font-size:16px;">模拟酸性胃液的介质,</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">适用于酸中稳定的药物,浓度一般为0.1～0.01mol/L，pH值一般为1.0～2.2</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;24px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;24px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;"><span style="font-size:16px;">磷酸盐缓冲液(PBS)</span><strong><span style="font-size:16px;">——</span></strong><span style="font-size:16px;">模拟中等酸性至弱碱性胃液或肠液的介质,</span></span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">浓度一般为0.05mol/L，pH值一般为4.5～7.6</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;24px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;24px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">醋酸盐缓冲液</span><strong><span style="line-height:21px;font-size:16px;">——</span></strong><span style="line-height:21px;font-size:16px;">模拟中等酸性胃液的介质, 浓度一般为0.05mol/L，pH值一般为3.4～6.0,</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">醋酸易挥发，导致pH值变化，溶出速率变化、测定时间长的药物不宜采用醋酸盐缓冲液作介质</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;24px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="font-size:14px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">普通制剂</span></strong><strong><span style="font-size:16px;"> ：</span></strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(1)酸性药物制剂 pH值分别为1.0或1.2、5.5~6.5、6.8~7.5和水；</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(2)中性或碱性药物/包衣制剂 pH值分别为1.0或1.2、3.0~5.0、6.8和水；</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(3)难溶性药物制剂 pH值分别为1.0或1.2、4.0~4.5、6.8和水；</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(4)肠溶制剂 pH值分别为1.0或1.2、6.0、6.8和水；</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="font-size:14px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">调释制剂</span></strong><strong><span style="font-size:16px;"> ：</span></strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;24px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">pH值分别为1.0或1.2、3.0～5.0、6.8～7.5和水</span><span style="font-size:16px;line-height:21px;">查询药物的PKa值，PKa＜3.0,为酸性物质；PKa≥3.0为碱性/中性药物</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">介质的</span></strong><strong><span style="line-height:21px;font-size:16px;">pH</span></strong><strong><span style="line-height:21px;font-size:16px;">值</span></strong><strong><span style="line-height:21px;font-size:16px;">:</span></strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="font-size:16px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">原则：</span></strong></span><span style="font-size:16px;"><span style="line-height:21px;font-size:16px;">根据体内吸收部位的pH值环境</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">      药物溶解度对pH值的敏感性(pH-溶解度曲线测定：取过量的原料药，置具塞试管中，分别加PH1.0-8.0的溶出介质适量，使之成饱和溶液，过滤，取续滤液经HPLC法测定准确溶度，计算溶解度并绘制pH-溶解度曲线；观察曲线与PH的变化情况)。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">       药物的稳定性来选择介质的pH值（确保主成分在溶出介质中的稳定性）。</span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">2. </span></strong><strong><span style="line-height:21px;font-size:16px;">溶出体积的选择</span></strong></span> </p> <p style="text-align:justify;"> <span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;"><br /> </span></strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;40px;background-color:#FFFFFF;"> <span style="font-size:16px;">篮法和桨法的溶出体积应在500～1000ml，目前多采用大杯法900-1000ml。除有充足理由。不建议采用该范围以外的体积。该体积范围的设定是为满足药物的漏槽条件 —— 溶出介质体积应大于药物全部溶解所需体积的三倍，以保证药物溶出不受其溶解性影响而设。而对于小杯法是相对小规格固体制剂，当采用紫外法检测无法满足测定要求时，从第二法衍生改良而得，截至目前仅我国收载。但该法对于某些活性成分，由于无法满足溶出度试验漏槽条件的要求，故建议在新产品溶出度研究与拟定上尽量勿采用该法，解决的办法：</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">①加大进样量浓度至100~200μl。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">②调整流动相使主成分保留时间缩短，色谱峰成“尖峰”状，积分将更加准确、精密度自然提高。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:16px;">③不选*大吸收波长，选择末端强吸收处波长作为检测波长，以加大响应值。</span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="color:#0070C0;"><strong><span style="font-size:16px;">3.</span></strong><strong><span style="font-size:16px;">溶出方法装置和转速的选择</span></strong></span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="font-size:16px;">篮法和桨法是目前通用性*强、耐用性*高、仪器*为普及的法定溶出方法，因此，建议******该两法，</span><span style="color:windowtext;font-size:16px;">桨法</span><strong><span style="color:windowtext;font-size:16px;">—</span></strong><span style="color:windowtext;font-size:16px;">******，只要药物不上浮就应选桨法，推荐50转/分，</span><span style="font-size:16px;">一般选用50~75rpm，不推荐采用100转甚至更高的转速，因为这将严重降低对于不同来源同一制剂的区分力，且大大降低体内外相关性，除非在已验证该制剂体内具有良好生物利用度的前提下，并应提供充足的理由与验证资料</span><span style="color:windowtext;font-size:16px;">；转篮法推荐100转/分，</span><span style="font-size:16px;">一般选用50~100rpm；桨法通常将转篮法/100转强度看作与桨板法/50转相当、且将该强度看作与中老年人体的胃肠道蠕动强度等同；当采用桨法/75rpm试验条件难以准确评价质量时，可改为篮法/120rpm</span><span style="color:windowtext;font-size:16px;">。但是在某溶出介质中，当结束时间点溶出量仍达不到90%，缓/控85%时，可放宽溶出参数，如现增加转速75转/分，未果的话可以加入表面活性剂。</span></span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="color:#0070C0;"><strong><span style="font-size:16px;">4. </span></strong><strong><span style="font-size:16px;">测定时间点和结束时间点的设定</span></strong></span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;21px;background-color:#FFFFFF;"> <span style="font-size:16px;color:#0070C0;"><strong>测定时间点：</strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;21px;background-color:#FFFFFF;"> <span style="font-size:16px;color:windowtext;">普通和肠溶制剂可分别为5、10、15、20、30、45、60、90120min，此后每隔1小时测定</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;21px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;21px;background-color:#FFFFFF;"> <span style="font-size:16px;color:windowtext;">缓/控制剂：15、30、45、60、90分钟和2、3、4、5、6、8、10、12、24小时</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;21px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;21px;background-color:#FFFFFF;"> <span style="font-size:16px;color:#0070C0;"><strong>结束时间点：</strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;21px;background-color:#FFFFFF;"> <span style="font-size:16px;color:windowtext;">在酸性介质（ph1.0-3.0）中*长为2h，其他PH介质中，普通和肠溶为6h，缓/控为24h，担当连续两点达90%（缓/控85%），且差值小于5%时，可提前结束。</span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="color:#0070C0;"><strong><span style="font-size:16px;">5. </span></strong><strong><span style="font-size:16px;">取样时间点和限度的拟定</span></strong></span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;22px;background-color:#FFFFFF;"> <span style="font-size:14px;color:windowtext;"><span style="font-size:16px;">高溶解度且快速溶解产品：单个时间点，大多数情况。对于普通制剂，建议以**次出现溶出量均在85%（或90%）以上的两时间点，且该两点溶出量差值在5%以内，取前一时间点作为质量标准中的</span><span style="color:#0070C0;font-size:16px;"><strong>取样时间点</strong></span><span style="font-size:16px;">，并将该点的溶出量减去15%作为</span><span style="color:#0070C0;font-size:16px;"><strong>溶出限度</strong></span><span style="font-size:16px;">。取样时间一般为5的倍数，3以上可向上约靠。</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:16px;">低溶解度且溶出缓慢的制剂或对溶出度有特殊要求的制剂：两个时间点</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">缓释制剂：药物作用8小时的一般至少设3个时间点</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">               作用12～16小时的至少设4个时间点</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="color:windowtext;font-size:16px;line-height:21px;">               </span><span style="line-height:1.75em;color:windowtext;font-size:16px;">作用24小时或以上的至少设5个时间点</span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">6. </span></strong><strong><span style="line-height:21px;font-size:16px;">含量测定方法的选择与验证</span></strong></span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="font-size:16px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">原则</span></strong></span><span style="font-size:16px;"><span style="line-height:21px;font-size:16px;">：专属好、重复性好、方便快捷、易于自动化</span></span><span style="font-size:16px;line-height:21px;">尽可能与含量测定方法相同</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;56px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="font-size:14px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">紫外分光光度法</span><span style="line-height:21px;font-size:16px;">——</span><span style="line-height:21px;font-size:16px;">******</span></strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:16px;">无紫外吸收的，可衍生化后比色</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">溶出度测定普遍采用方便快捷的UV法，但一定要注意辅料的干扰。特别是在短波长处，更应注意辅料的末端吸收等干扰因素的存在。一般认为辅料的干扰应在2%以内，否则UV法不适用。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">采用UV法测定前，一定要进行紫外扫描，以考察辅料是否存在干扰。方法为：分别取对照品溶液和供试品溶液（浓度*好与对照品溶液一致或略低），进行紫外扫描。着重观察供试品溶液图谱情况：是否存在基线被抬升的现象，以及与对照品溶液图谱重合的情况。如辅料无干扰，则供试品溶液图谱应与对照品溶液图谱基本重合或整体略低于对照品图谱；如辅料有干扰，就会出现基线或末端吸收处被抬高的现象。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:center;0em;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <img class="" src="https://img.kq36.com.cn/oss/kq133/News/2019/5/16/161626542977584.jpg!source" style="height:auto !important;width:618px !important;" /> </p> <p style="text-align:justify;0em;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:18px;">图1 供试品溶液图谱（上方）与对照品溶液图谱（下方）相比，基线被整体“抬高”</span> </p> <p style="text-align:center;0em;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:14px;"><img class="" src="https://img.kq36.com.cn/oss/kq133/News/2019/5/16/161627106497612.jpg!source" style="height:auto !important;width:432px !important;" /></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:12px;"><span style="line-height:18px;font-size:16px;">图2 辅料呈一“斜坡形”吸收（下方图谱），</span><span style="font-size:16px;"> </span><span style="line-height:18px;font-size:16px;">在测定波长处的吸收度值约占供试品溶液（上方图谱）的5%左右</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">  另一方法可采用</span><span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">HPLC</span></strong><strong><span style="line-height:21px;font-size:16px;">法</span></strong></span><span style="line-height:21px;font-size:16px;">，将其测定结果与UV法进行比较，以判定辅料是否有干扰。</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:16px;color:#0070C0;"><strong>当辅料干扰紫外法测定时，通常可采用以下方法：</strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:16px;">双波长吸收度差值法、</span><span style="font-size:16px;line-height:21px;">导数光谱法</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:14px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">HPLC</span></strong><strong><span style="line-height:21px;font-size:16px;">法</span></strong><span style="line-height:21px;font-size:16px;">：</span></span><span style="font-size:16px;line-height:21px;">在HPLC色谱柱上可轻松将辅料与主成分分离，该法测定*为准确、可靠，只是工作量略显增加。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;2em;background-color:#FFFFFF;"> <span style="font-size:16px;color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">验证：</span></strong></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;">溶出度检测方法按照既定的方法学认证各项要求验证，尚需注意以下各事项：</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(1) 对于某些难溶性药物，如难以采用溶出介质直接溶解对照品，可先加少量有机溶剂（如甲醇或乙醇）溶解后，再加溶出介质稀释的办法，建议*终溶液中有机相比例不超过5%。如超出，应予以相应验证。</span> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(2) 线性范围应考虑到有可能出现的低浓度点情况，如对于溶出曲线或调释制剂的测定等。并为减小外标一点法的测定误差，建议将对照品溶液配制为约50%释放量浓度。</span> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(3) 应注意考察活性成分在37℃溶出介质中的稳定性。若不佳，应在质量标准中标注“取出后立即测定的”字样；不建议在溶出介质中加入抗氧剂、稳定剂等物质。</span> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(4) 根据实际情况，检测波长可选取非*大吸收波长。</span> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">(5) 当测定法为紫外法时，由于易受辅料或胶囊壳的影响，建议分别取对照品溶液与供试品溶液进行紫外扫描后根据所得图谱予以明了，亦可采用高效液相法进行佐证。如干扰存</span><span style="font-size:16px;"> </span><span style="line-height:21px;font-size:16px;">在，可考虑采用双波长相减法或******胶囊壳扣除法等方法予以消除，不建议采用紫外导数光谱法；如干扰排除较为困难，建议采用高效液相色谱法测定。</span></span> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(6) ******胶囊壳干扰在2%以内可忽略不计；若大于2%则应校正，并在该品种项下予以注明；大于25%时，则被视为溶出试验无效，应重新选择测定方法。关于其测定法，建议取6粒样品，彻底清除其中内容物，同法试验和过滤后，分别量取相同体积混匀测定。测定时、以相应溶剂为******。</span> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">(7) 不应出现溶出度测定结果均值高于含量测定结果3%以上的情况。如出现，应重新考察溶出度测定方法的适用性。</span> </p> <p style="margin-left:32px;text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">      (8) 对于小规格制剂，不建议采用大于1cm的吸收池进行紫外法测定，而建议采用HPLC法（并可酌情加大进样量以提高测定精密度）。但对于具有较强紫外吸收的活性药物，为提高工作效率，可在溶出曲线大批量样品测定时，采用0.1cm~1.0cm短吸收池，但必须经过验证。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">       (9) 对一些小规格制剂，样品过滤时会发生吸附，判定吸附与否的方法可采用：</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">        ①取溶出液，分别过滤不同体积的初滤液后测定，观察响应值的变化情况，、</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:16px;">②取样后一份不过滤，直接采用高速离心，取上清液测定。并与采用过滤法所得的续滤液比较，考察两者间测定数据的差异。判定自动取样溶出仪的固有滤膜是否存在吸附时，一般采用该法。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">③取对照品溶液，经滤膜过滤后，与原溶液进行比较，观察测定前后数据的变化情况。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">如滤膜对药物有吸附，可采用将滤膜在沸水中煮沸1h，或加大初滤液体积等办法予以解决。但建议采用直接高速离心的方法。</span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;"> <span style="color:#0070C0;"><strong><span style="line-height:21px;font-size:16px;">7. </span></strong><strong><span style="line-height:21px;font-size:16px;">溶出曲线比较</span></strong></span> </p> <p style="color:#333333;font-family:-apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif;font-size:17px;text-align:justify;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:16px;">产品上市发生较小的变更时，采用单点溶出度试验可能就足以确认其是否未改变产品的质量和性能。发生较大变更时，则推荐对变更前后产品在相同的溶出条件下进行溶出曲线比较。在整体溶出曲线相似以及每一采样时间点溶出度相似时，可认为二者溶出行为相似。</span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">由于多</span><span style="color:#0070C0;font-size:16px;"><strong><span style="line-height:21px;font-size:16px;">pH</span></strong></span><span style="line-height:21px;font-size:16px;">值溶出曲线的绘制已成为剖析和表达固体制剂内在品质的重要手段，故对溶出曲线比较的科学评价愈发重要。截至目前，报道有多种比较方法。</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;32px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">但自美国和日本等国的官方机构认定采用模型非依赖方法之一的</span><strong><span style="line-height:21px;font-size:16px;">“</span></strong><span style="line-height:21px;font-size:16px;">相似因子比较法</span><strong><span style="line-height:21px;font-size:16px;">”</span></strong><span style="line-height:21px;font-size:16px;">之后，现基本上被统一采纳。该法特点是对溶出曲线进行整体评价，通过计算相似因子</span><span style="color:#0070C0;"><strong><span style="line-height:21px;"><span style="font-size:16px;">(ƒ</span><sub><span style="font-size:16px;">2</span></sub><span style="font-size:16px;">)</span></span></strong></span><span style="line-height:21px;font-size:16px;">比较溶出行为的相似性。</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <br /> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;">通常，当</span><span style="color:#0070C0;"><strong><span style="line-height:21px;"><span style="font-size:16px;">ƒ</span><sub><span style="font-size:16px;">2</span></sub></span></strong></span><span style="line-height:21px;font-size:16px;">数值介于</span><span style="color:#0070C0;font-size:16px;"><strong><span style="line-height:21px;font-size:16px;">50-100</span></strong></span><span style="line-height:21px;font-size:16px;">认为两条溶出曲线是相似的，该数值限定是基于两条比较曲线上任一比较时间点溶出量平均差异限度不大于</span><span style="color:#0070C0;font-size:16px;"><strong><span style="line-height:21px;font-size:16px;">10%</span></strong></span><span style="line-height:21px;font-size:16px;">的考虑。表</span><span style="color:#0070C0;font-size:16px;"><strong><span style="line-height:21px;font-size:16px;">5</span></strong></span><span style="line-height:21px;font-size:16px;">提供了溶出量平均差异与相应</span><span style="color:#0070C0;"><strong><span style="line-height:21px;"><span style="font-size:16px;">ƒ</span><sub><span style="font-size:16px;">2</span></sub></span></strong></span><span style="line-height:21px;font-size:16px;">因子临界值的关系。</span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;31px;background-color:#FFFFFF;"> <span style="font-size:14px;"><span style="line-height:21px;font-size:16px;"><br /> </span></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="line-height:21px;font-size:14px;"><img class="" src="https://img.kq36.com.cn/oss/kq133/News/2019/5/16/161627297269140.jpg!source" style="height:auto !important;width:675px !important;" /></span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;">     对于普通制剂，15min时溶出量达85%以上，则无需进行曲线比较，此时仿制制剂亦满足此条件。 </span> </p> <p style="text-align:justify;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="font-size:16px;line-height:21px;"><br /> </span> </p> <p style="text-align:right;color:#3E3E3E;font-family:微软雅黑;font-size:16px;background-color:#FFFFFF;"> <span style="color:#888888;font-size:16px;">本文来源于百度文库</span> </p> <span style="font-size:16px;"> <div style="text-align:justify;"> <span style="line-height:1.5;"></span> </div> </span> <p> <br /> </p></div> <div style="clear: both; padding-top: 50px; text-indent: 2em;"> <p style="font-size: 16px; color: #FF3300; font-weight: bold"> <span style="color: #000000">2万家医药制药招聘，6万名药师求职，上康强医疗人才网</span><font color="#FF9900"> <a href="https://www.kq36.com" 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document.getElementById("CommentModel_Content").value += ToAdd; } var pingdvportrait = document.getElementById("pingdvportrait"); pingdvportrait.style.display = "none"; } function addpingpingportrait(e) { if (pinggIEVer <= 5.01 && gIsIE) { return; } var pingdvportrait = document.getElementById("pingdvportrait"); var pingtbpingportrait = document.getElementById("pingtbpingportrait"); var iX = e.clientX; var iY = e.clientY; var y = e.y; var z = document.body.scrollTop; pingdvportrait.style.display = ""; pingdvportrait.onmouseout = function () { var pingdvportrait = this, ea = window.event; if (!pingdvportrait.contains(ea.toElement || ea.fromElement)) pingdvportrait.style.display = 'none' } if (window.screen.width == 1024) { pingdvportrait.style.left = (iX - 50) + "px"; } else { if (gIsIE) pingdvportrait.style.left = (iX - 50) + "px"; else pingdvportrait.style.left = (iX - 50) + "px"; } //pingdvportrait.style.top = (iY-15) + "px"; pingdvportrait.style.pixelTop = y + z - 10; pingdvportrait.innerHTML = '<TABLE id="pingtbpingportrait" cellSpacing="1" cellPadding="5" width="100%" bgColor="black" border="0" > <TBODY> ' + face_01 + more_01 + ' </TBODY> </TABLE>'; } var face_01 = '<TR id="trContent" align="left" bgColor="#f8f8f8"> <TD align="middle"><IMG onclick="pingputEmot(\'em01\');" height="19" alt="" src="' + imagePath + 'smile01.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em02\');" height="19" alt="" src="' + imagePath + 'smile02.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em03\');" height="19" alt="" src="' + imagePath + 'smile03.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em04\');" height="19" alt="" src="' + imagePath + 'smile04.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em05\');" height="19" alt="" src="' + imagePath + 'smile05.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em06\');" height="19" alt="" src="' + imagePath + 'smile06.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em07\');" height="19" alt="" src="' + imagePath + 'smile07.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em08\');" height="19" alt="" src="' + imagePath + 'smile08.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em09\');" height="19" alt="" src="' + imagePath + 'smile09.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em10\');" height="19" alt="" src="' + imagePath + 'smile10.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em11\');" height="19" alt="" src="' + imagePath + 'smile11.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em12\');" height="19" alt="" src="' + imagePath + 'smile12.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em13\');" height="19" alt="" src="' + imagePath + 'smile13.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em14\');" height="19" alt="" src="' + imagePath + 'smile14.gif" width="19"></TD> </TR> <TR align="left" bgColor="#f8f8f8"> <TD align="middle"><IMG onclick="pingputEmot(\'em15\');" height="19" alt="" src="' + imagePath + 'smile15.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em16\');" height="19" alt="" src="' + imagePath + 'smile16.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em17\');" height="19" alt="" src="' + imagePath + 'smile17.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em18\');" height="19" alt="" src="' + imagePath + 'smile18.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em19\');" height="19" alt="" src="' + imagePath + 'smile19.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em20\');" height="19" alt="" src="' + imagePath + 'smile20.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em21\');" height="19" alt="" src="' + imagePath + 'smile21.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em22\');" height="19" alt="" src="' + imagePath + 'smile22.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em23\');" height="19" alt="" src="' + imagePath + 'smile23.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em24\');" height="19" alt="" src="' + imagePath + 'smile24.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em25\');" height="19" alt="" src="' + imagePath + 'smile25.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em26\');" height="19" alt="" src="' + imagePath + 'smile26.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em27\');" height="19" alt="" src="' + imagePath + 'smile27.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em28\');" height="19" alt="" src="' + imagePath + 'smile28.gif" width="19"></TD> </TR> '; var more_01 = ' <tr ><td colspan="14" bgColor="#f8f8f8" align="center"><a href="javascript:void(0);" onclick="more_face();" >更多</a></td></tr> '; var face_02 = ' <TR align="left" bgColor="#f8f8f8"> <TD align="middle"><IMG onclick="pingputEmot(\'em29\');" height="19" alt="" src="' + imagePath + 'smile29.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em30\');" height="19" alt="" src="' + imagePath + 'smile30.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em31\');" height="19" alt="" src="' + imagePath + 'smile31.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em32\');" height="19" alt="" src="' + imagePath + 'smile32.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em33\');" height="19" alt="" src="' + imagePath + 'smile33.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em34\');" height="19" alt="" src="' + imagePath + 'smile34.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em35\');" height="19" alt="" src="' + imagePath + 'smile35.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em36\');" height="19" alt="" src="' + imagePath + 'smile36.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em37\');" height="19" alt="" src="' + imagePath + 'smile37.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em38\');" height="19" alt="" src="' + imagePath + 'smile38.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em39\');" height="19" alt="" src="' + imagePath + 'smile39.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em40\');" height="19" alt="" src="' + imagePath + 'smile40.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em41\');" height="19" alt="" src="' + imagePath + 'smile41.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em42\');" height="19" alt="" src="' + imagePath + 'smile42.gif" width="19"></TD> </TR> <TR align="left" bgColor="#f8f8f8"> <TD align="middle"><IMG onclick="pingputEmot(\'em43\');" height="19" alt="" src="' + imagePath + 'smile43.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em44\');" height="19" alt="" src="' + imagePath + 'smile44.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em45\');" height="19" alt="" src="' + imagePath + 'smile45.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em46\');" height="19" alt="" src="' + imagePath + 'smile46.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em47\');" height="19" alt="" src="' + imagePath + 'smile47.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em48\');" height="19" alt="" src="' + imagePath + 'smile48.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em49\');" height="19" alt="我是男生" src="' + imagePath + '49.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em50\');" height="19" alt="我是女生" src="' + imagePath + '50.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em51\');" height="19" alt="玫瑰" src="' + imagePath + '51.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em52\');" height="19" alt="好爱你" src="' + imagePath + '52.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em53\');" height="19" alt="心碎了" src="' + imagePath + '53.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em54\');" height="19" alt="亲亲" src="' + imagePath + '54.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em55\');" height="19" alt="NO" src="' + imagePath + '55.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em56\');" height="19" alt="YES" src="' + imagePath + '56.gif" width="19"></TD> </TR> '; var more_02 = ' <tr><td colspan="14" bgColor="#f8f8f8" align="center"><a href="javascript:void(0);" onclick="more_face_02();">更多</a></td></tr> '; var face_03 = ' <TR align="left" bgColor="#f8f8f8"> <TD align="middle"><IMG onclick="pingputEmot(\'em57\');" height="19" alt="握个手" src="' + imagePath + '57.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em58\');" height="19" alt="到点了" src="' + imagePath + '58.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em59\');" height="19" alt="音乐" src="' + imagePath + '59.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em60\');" height="19" alt="CALL我" src="' + imagePath + '60.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em61\');" height="19" alt="带血的刀" src="' + imagePath + '61.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em62\');" height="19" alt="炸弹" src="' + imagePath + '62.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em63\');" height="19" alt="有了" src="' + imagePath + '63.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em64\');" height="19" alt="好晚了" src="' + imagePath + '64.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em65\');" height="19" alt="吸血蝙蝠" src="' + imagePath + '65.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em66\');" height="19" alt="便便" src="' + imagePath + '66.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em67\');" height="19" alt="干一杯" src="' + imagePath + '67.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em68\');" height="19" alt="抽烟" src="' + imagePath + '68.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em69\');" height="19" alt="打电话" src="' + imagePath + '69.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em70\');" height="19" alt="家" src="' + imagePath + '70.gif" width="19"></TD> </TR> <TR align="left" bgColor="#f8f8f8"> <TD align="middle"><IMG onclick="pingputEmot(\'em71\');" height="19" alt="车子" src="' + imagePath + '71.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em72\');" height="19" alt="礼物" src="' + imagePath + '72.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em73\');" height="19" alt="金钱" src="' + imagePath + '73.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em74\');" height="19" alt="太阳" src="' + imagePath + '74.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em75\');" height="19" alt="下雨" src="' + imagePath + '75.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em76\');" height="19" alt="猪猪" src="' + imagePath + '76.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em77\');" height="19" alt="小猫" src="' + imagePath + '77.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em78\');" height="19" alt="小狗" src="' + imagePath + '78.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em79\');" height="19" alt="骨头" src="' + imagePath + '79.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em80\');" height="19" alt="喝水" src="' + imagePath + '80.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em81\');" height="19" alt="汉堡" src="' + imagePath + '81.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em82\');" height="19" alt="包子" src="' + imagePath + '82.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em83\');" height="19" alt="西瓜" src="' + imagePath + '83.gif" width="19"></TD> <TD align="middle"><IMG onclick="pingputEmot(\'em84\');" height="19" alt="约会" src="' + imagePath + '84.gif" width="19"></TD> </TR> '; var more_03 = '<tr><td colspan="14" bgColor="#f8f8f8" align="center"><a href="javascript:void(0);" onclick="face();">取消更多</a></td></tr>'; function more_face() { pingdvportrait.innerHTML = '<TABLE id="pingtbpingportrait" cellSpacing="1" cellPadding="5" width="100%" bgColor="black" border="0" > <TBODY> ' + face_01 + face_02 + more_02 + ' </TBODY> </TABLE>'; } function more_face_02() { pingdvportrait.innerHTML = '<TABLE id="pingtbpingportrait" cellSpacing="1" cellPadding="5" width="100%" bgColor="black" border="0" > <TBODY> ' + face_01 + face_02 + face_03 + more_03 + ' </TBODY> </TABLE>'; } function face() { pingdvportrait.innerHTML = '<TABLE id="pingtbpingportrait" cellSpacing="1" cellPadding="5" width="100%" bgColor="black" border="0" > <TBODY> ' + face_01 + more_01 + ' </TBODY> </TABLE>'; } function pingFacial(str) { str = newpingportrait(str, "smile01.gif", "[em01]", "闹"); str = newpingportrait(str, "smile02.gif", "[em02]", "色"); str = newpingportrait(str, "smile03.gif", "[em03]", "可恨"); str = newpingportrait(str, "smile04.gif", "[em04]", "害羞"); str = newpingportrait(str, "smile05.gif", "[em05]", "抽煙"); str = newpingportrait(str, "smile06.gif", "[em06]", "中星星"); str = newpingportrait(str, "smile07.gif", "[em07]", "眨眼"); str = newpingportrait(str, "smile08.gif", "[em08]", "噓"); str = newpingportrait(str, "smile09.gif", "[em09]", "暈"); str = newpingportrait(str, "smile10.gif", "[em10]", "喝茶"); str = newpingportrait(str, "smile11.gif", "[em11]", "饥饿"); str = newpingportrait(str, "smile12.gif", "[em12]", "拜拜"); str = newpingportrait(str, "smile13.gif", "[em13]", "生气"); str = newpingportrait(str, "smile14.gif", "[em14]", "流口水"); str = newpingportrait(str, "smile15.gif", "[em15]", "闭嘴"); str = newpingportrait(str, "smile16.gif", "[em16]", "发怒"); str = newpingportrait(str, "smile17.gif", "[em17]", "很棒"); str = newpingportrait(str, "smile18.gif", "[em18]", "弱"); str = newpingportrait(str, "smile19.gif", "[em19]", "心碎"); str = newpingportrait(str, "smile20.gif", "[em20]", "爱心"); str = newpingportrait(str, "smile21.gif", "[em21]", "示爱 "); str = newpingportrait(str, "smile22.gif", "[em22]", "凋谢"); str = newpingportrait(str, "smile23.gif", "[em23]", "玫瑰"); str = newpingportrait(str, "smile24.gif", "[em24]", "礼物"); str = newpingportrait(str, "smile25.gif", "[em25]", "苹果"); str = newpingportrait(str, "smile26.gif", "[em26]", "西瓜"); str = newpingportrait(str, "smile27.gif", "[em27]", "喝茶"); str = newpingportrait(str, "smile28.gif", "[em28]", "聊天"); str = newpingportrait(str, "smile29.gif", "[em29]", "星星"); str = newpingportrait(str, "smile30.gif", "[em30]", "唧唧歪歪"); str = newpingportrait(str, "smile31.gif", "[em31]", "调皮"); str = newpingportrait(str, "smile32.gif", "[em32]", "戴绿帽子"); str = newpingportrait(str, "smile33.gif", "[em33]", "眨眼"); str = newpingportrait(str, "smile34.gif", "[em34]", "抛媚眼"); str = newpingportrait(str, "smile35.gif", "[em35]", "猪头"); str = newpingportrait(str, "smile36.gif", "[em36]", "吃屎"); str = newpingportrait(str, "smile37.gif", "[em37]", "月亮"); str = newpingportrait(str, "smile38.gif", "[em38]", "音符"); str = newpingportrait(str, "smile39.gif", "[em39]", "下雨"); str = newpingportrait(str, "smile40.gif", "[em40]", "猫猫头"); str = newpingportrait(str, "smile41.gif", "[em41]", "小狗"); str = newpingportrait(str, "smile42.gif", "[em42]", "骷头"); str = newpingportrait(str, "smile43.gif", "[em43]", "书呆子"); str = newpingportrait(str, "smile44.gif", "[em44]", "太阳"); str = newpingportrait(str, "smile45.gif", "[em45]", "写信给我"); str = newpingportrait(str, "smile46.gif", "[em46]", "抛媚眼"); str = newpingportrait(str, "smile47.gif", "[em47]", "电视"); str = newpingportrait(str, "smile48.gif", "[em48]", "闹钟"); str = newpingportrait(str, "49.gif", "[em49]", "我是男生"); str = newpingportrait(str, "50.gif", "[em50]", "我是女生"); str = newpingportrait(str, "51.gif", "[em51]", "玫瑰"); str = newpingportrait(str, "52.gif", "[em52]", "好爱你"); str = newpingportrait(str, "53.gif", "[em53]", "心碎了"); str = newpingportrait(str, "54.gif", "[em54]", "亲亲"); str = newpingportrait(str, "55.gif", "[em55]", "NO"); str = newpingportrait(str, "56.gif", "[em56]", "YES"); str = newpingportrait(str, "57.gif", "[em57]", "握个手"); str = newpingportrait(str, "58.gif", "[em58]", "到点了"); str = newpingportrait(str, "59.gif", "[em59]", "音乐"); str = newpingportrait(str, "60.gif", "[em60]", "CALL我"); str = newpingportrait(str, "61.gif", "[em61]", "带血的刀"); str = newpingportrait(str, "62.gif", "[em62]", "炸弹"); str = newpingportrait(str, "63.gif", "[em63]", "有了"); str = newpingportrait(str, "64.gif", "[em64]", "好晚了"); str = newpingportrait(str, "65.gif", "[em65]", "吸血蝙蝠"); str = newpingportrait(str, "66.gif", "[em66]", "便便"); str = newpingportrait(str, "67.gif", "[em67]", "干一杯"); str = newpingportrait(str, "68.gif", "[em68]", "抽烟"); str = newpingportrait(str, "69.gif", "[em69]", "打电话"); str = newpingportrait(str, "70.gif", "[em70]", "家"); str = newpingportrait(str, "71.gif", "[em71]", "车子"); str = newpingportrait(str, "72.gif", "[em72]", "礼物"); str = newpingportrait(str, "73.gif", "[em73]", "金钱"); str = newpingportrait(str, "74.gif", "[em74]", "太阳"); str = newpingportrait(str, "75.gif", "[em75]", "下雨"); str = newpingportrait(str, "76.gif", "[em76]", "猪猪"); str = newpingportrait(str, "77.gif", "[em77]", "小猫"); str = newpingportrait(str, "78.gif", "[em78]", "小狗"); str = newpingportrait(str, "79.gif", "[em79]", "骨头"); str = newpingportrait(str, "80.gif", "[em80]", "喝水"); str = newpingportrait(str, "81.gif", "[em81]", "汉堡"); str = newpingportrait(str, "82.gif", "[em82]", "包子"); str = newpingportrait(str, "83.gif", "[em83]", "西瓜"); str = newpingportrait(str, "84.gif", "[em84]", "约会"); return str } function newpingportrait(str, str1, str2, str3) { var newstr = str.replace(str2, '<img src=.././Content/Images/smiles/' + str1 + ' title=' + str3 + '/>'); //var newstr = str.replace(str2, '<img src="http://img.kq36.com.cn/htmleditor/images/smiles/"/+str1+"/>'); return newstr; } </script> </div> <div style="float: right; margin-top: -25px;"> <a name="Submit" onclick="return checkinput(104986);" style="cursor: pointer;"> <img src="/Content/Images/Advertisin.png"/></a> </div> </div> <a name="ping"></a> </div> </div> </td> </tr> </table> <table width="90%" border="0" cellpadding="0" cellspacing="0" bgcolor="#F7FCFF" style="margin: 5px auto;"> <tr> <td bgcolor="#fffff" valign="top"> <div style="background-color: #F7FCFF;"> <div style="border-bottom: #23619E 1px solid; height: 20px; padding-left: 5px; padding-top: 50px;"> <strong style="color: #23619E; font-size: 14px;">热门评论</strong> </div> <br /> <div style="text-align: center;"> <span style="font-size: 15px; color: #0079C2">暂无热门评论</span></div> <br /> </div> </td> </tr> <tr> <td valign="top"> <div style="background-color: #F7FCFF;"> <div style="border-bottom: #23619E 1px solid; height: 20px; padding-left: 5px; padding-top: 50px;"> <strong style="color: #23619E; font-size: 14px;">最新评论</strong> </div> <br /> <div style="text-align: center;"> <span style="font-size: 15px; color: #0079C2">暂无最新评论</span></div> <br />  </div> </td> </tr> </table> </td> </tr> </table> </div> <div class="ping_info" style="float: left; margin: 15px 0px 0 0px; padding-bottom: 20px;"> <table width="100%" border="0" align="center" cellpadding="0" cellspacing="0" style="margin-top: 8px;"> <tr> <td> <script src="/Scripts/jquery-1.7.1.min.js"></script> <style type="text/css"> * { padding: 0; list-style: none; } .tabs { margin: 10px; border-bottom: 1px solid #BECBD2; } .tabs-nav:before, .tabs-nav:after { display: table; content: ' '; } .tabs-nav:after { width: 100%; clear: both; border-bottom: 1px solid #BECBD2; } .tabs-nav li { position: relative; float: left; margin-right: 5px; border: 1px solid #becbd2; border-bottom: none; } .tabs-nav li.active:after { position: absolute; bottom: -1px; width: 100%; display: block; content: ' '; border-bottom: 1px solid #fff; } .tabs-nav a { display: block; padding: 0 10px; line-height: 30px; text-decoration: none; color: #23619E; font-size: 14px; } .tabs-nav a:hover { text-decoration: underline; } .tabs-cnt { padding: 10px; border-left: 1px solid #BECBD2; border-right: 1px solid #BECBD2; } .tabs-content { display: none; } .tabs-content:first-child { display: block; } .tabs-content a { display: block; float: left; width: 670px; height: 24px; padding-left: 20px; background-image: url(../../Content/image/icon_02.gif); background-repeat: no-repeat; background-position: left 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<div style="margin-top: 5px;"> <span>Copyright © 厦门酷启人才服务有限公司</span></div> </div> </div> </div> <script language="javascript" type="text/javascript"> function addNews() { $.layer({ type: 2, border: [0], title: false, shadeClose: true, iframe: { src: '/Home/EdNewWeb/0' }, area: ['1000px', '550px'] }); } </script> </div> <script src='https://img.kq36.com.cn/js/jquery-1.7.2.min.js'></script> <script type="text/javascript"> window._bd_share_config = { "common": { "bdSnsKey": {}, "bdText": "", "bdMini": "2", "bdMiniList": false, "bdPic": "", "bdStyle": "0", "bdSize": "16" }, "image": { "viewList": ["qzone", "tsina", "tqq", "renren", "weixin"], "viewText": "分享到：", "viewSize": "16" }, "share": {} }; with (document) 0[(getElementsByTagName('head')[0] || body).appendChild(createElement('script')).src = 'https://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion=' + ~(-new Date() / 36e5)]; $(document).ready(function(){ var vid=104986; $.getJSON("/Ajax/Ajax_comm.aspx", { type: "retnewinfo",id:vid, ClassIID: $("#News_ClassI_Id").val(), random: new Date().getTime() }, function (data) { $("#viewvisit").html(data.ic); if (data.dataimg != "") { //alert(data.dataimg); $("#tablehotimgsc1").append(data.dataimg); $("#tablehotimgsc1").show(); } if (data.dataimg2 != "") { $("#tablehotimgsc2").append(data.dataimg2); } if(data.dataimgnew!=""){ $("#tablehotnewsc1").append(data.dataimgnew); $("#tablehotnewsc1").show(); } if(data.dataimgnew2!=""){ $("#tablehotnewsc2").append(data.dataimgnew2); } if(data.adlist){ $("#getimg").html(data.adlist); } }); }); $(function () { $("#pic1").each(function () { //var tmp; $(this).find('a').each(function () { //tmp = $(this).text(); //alert($(this).attr("href")); var thishref = $(this).attr("href"); $(this).attr("href", "javascript:;"); $(this).attr("onclick", "javascript:if(navigator.userAgent.toLowerCase().indexOf('kq36/android/touch/wx/oh/')!=-1){window.local_obj.OpenHttp('" + thishref + "');}else if(isMiniprogram){uni.navigateTo({url: '/pages/copyurl/copyurl?url=" + thishref + "'})}else{$(this).attr('href','" + thishref + "')}") }); }); var vid=104986; $.ajax({ url: '/Home/GetSubmitGood', type: "POST", data: { vId: vid }, success: function (data) { $("#sp_good").html(data); }, error: function () { } }); $.ajax({ url: '/Home/GetSubmitBad', type: "POST", data: { vId: vid }, success: function (data) { $("#sp_bad").html(data); }, error: function () { } }); }) function SubmitGood(vId,type) { $.ajax({ url: '/Home/SubmitGood', type: "POST", data: { vId: vId,type:type }, success: function (data) { if(type==1) { $("#sp_good").html(data); return false; } else{ $("#sp_bad").html(data); return false; } }, error: function () { } }); } </script> <script language="javascript" type="text/javascript"> function SubmitVote(vId, iName) { var checkVal = ""; $('input[name="' + iName + '"]:checked').each(function () { checkVal = checkVal + $(this).val() + "|"; $(this).attr("checked", false); }); if (checkVal == "") { alert("尚未选择任何投票项,请选择!") return false; } $.ajax({ url: '/Home/SubmitVote', type: "POST", data: { vId: vId, strCheckVal: checkVal }, success: function (data) { alert(data); }, error: function () { } }); } function showNews() { $("#dshow").show(); $("#pic").hide(); $("#hideNews").show(); } function hideNews() { $("#dshow").hide(); $("#pic").show(); $("#hideNews").hide(); } $(function () { // settablehotnewsc(1); // settablehotbbssc(2); // settablehotimgsc(1); // $("#hideNews").hide(); // $("#dshow").hide(); }) function settablehotimgsc(n) { if (n == 1) { document.getElementById("tablehotimgsc" + 1).style.display = ""; document.getElementById("tablehotimgsc" + 2).style.display = "none"; $("#w_img").css("background-image", "url(../../Content/image/btn_bg.gif)"); $("#m_img").css("background-image", ""); $("#m_img").css("margin-top", "7px"); } else { document.getElementById("tablehotimgsc" + 2).style.display = ""; document.getElementById("tablehotimgsc" + 1).style.display = "none"; $("#m_img").css("background-image", "url(../../Content/image/btn_bg.gif)"); $("#w_img").css("background-image", ""); $("#m_img").css("margin-top", "7px"); } } function settablehotnewsc(n) { if (n == 1) { document.getElementById("tablehotnewsc" + 1).style.display = ""; document.getElementById("tablehotnewsc" + 2).style.display = "none"; $("#w_news").css("background-image", "url(../../Content/image/btn_bg.gif)"); $("#m_news").css("background-image", ""); $("#m_news").css("margin-top", "7px"); } else { document.getElementById("tablehotnewsc" + 2).style.display = ""; document.getElementById("tablehotnewsc" + 1).style.display = "none"; $("#m_news").css("background-image", "url(../../Content/image/btn_bg.gif)"); $("#w_news").css("background-image", ""); $("#m_news").css("margin-top", "7px"); } } function settablehotbbssc(n) { if (n == 1) { //document.getElementById("tablehotbbssc" + 1).style.display = ""; document.getElementById("tablehotbbssc" + 2).style.display = "none"; $("#w_bbs").css("background-image", "url(../../Content/image/btn_bg.gif)"); $("#m_bbs").css("background-image", ""); $("#m_bbs").css("margin-top", "7px"); } else { document.getElementById("tablehotbbssc" + 2).style.display = ""; //document.getElementById("tablehotbbssc" + 1).style.display = "none"; $("#m_bbs").css("background-image", "url(../../Content/image/btn_bg.gif)"); $("#w_bbs").css("background-image", ""); $("#m_bbs").css("margin-top", "7px"); } } function checkTP(val) { $.layer({ type: 2, border: [0], title: false, shadeClose: true, iframe: { src: '/Home/ShowVote?ID=' + val + '' }, area: ['700px', '300px'] }); } function checkinput(newsID) { if ($("#CommentModel_Content").val() == "") { alert('请填写评论内容！'); $("#CommentModel_Content").focus(); return false; } if ($("#txtCode").val() == "") { alert('请输入验证码！'); $("#txtCode").focus(); return false; } else { $.ajax({ url: '/Home/AddComment', type: 'post', async: false, data: { id: $("#ID").val(), content: $("#CommentModel_Content").val(), title: $("#News_Title").val(), Classi_id: $("#News_ClassI_Id").val(), Code: $("#txtCode").val(), SessionID: $("#sessionID").val() }, success: function (result) { if (result == "True") { alert("评论成功！"); $("#CommentModel_Content").val(""); $("#txtCode").val(""); //location.href = "/A/" + newsID + ""; history.go(0); } else if (result == "1") { alert("验证码输入错误！"); $("#txtCode").val(""); $("#txtCode").focus(); Refesh(); return false; } else { alert("评论失败！"); return false; } } }); } } function addNews() { $.layer({ type: 2, border: [0], title: false, shadeClose: true, iframe: { src: '/Home/EdNewWeb/0' }, area: ['1000px', '550px'] }); } </script> </body> <script src="/Scripts/jquery-1.7.1.min.js"></script> <script src="/Scripts/Info.js"></script> <script src="/Scripts/layer/layer.min.js"></script> <script type="text/javascript"> //读取cookies function getCookie(name) { var arr, reg = new RegExp("(^| )" + name + "=([^;]*)(;|$)"); if (arr = document.cookie.match(reg)) return unescape(arr[2]); else return null; } //平台、设备和操作系统 var system = { win: false, mac: false, ipad: false, xll: false }; //检测平台 var p = navigator.platform; system.win = p.indexOf("Win") == 0; system.mac = p.indexOf("Mac") == 0; system.ipad = p.indexOf("iPad") == 0; system.x11 = (p == "X11") || (p.indexOf("Linux") == 0); //跳转语句 if (system.win || system.mac || system.ipad || system.xll) { } else { if (getCookie("mobile") == "yes" || getCookie("mobile") == null) { // top.location.href = 'https://m.kq133.com/A/104986'; } } function MM_over1(mmObj) { var mSubObj = mmObj.getElementsByTagName("div")[0]; mSubObj.style.display = "block"; } function MM_out1(mmObj) { var mSubObj = mmObj.getElementsByTagName("div")[0]; mSubObj.style.display = "none"; } </script> <script language="javascript" type="text/javascript"> function addNews() { $.layer({ type: 2, border: [0], title: false, shadeClose: true, // iframe: { src: 'Home/EdNewWeb/0' }, // iframe: { src: "/Home / EdNewWeb/" }, iframe: { src: '/Home/EdNewWeb/0' }, area: ['1000px', '550px'] }); } // function addNews() { // location.href = "Home/EdNewWeb/0"; // } function wsug(e, str) { var oThis = arguments.callee; if (!str) { oThis.sug.style.visibility = 'hidden'; document.onmousemove = null; return; } if (!oThis.sug) { var div = document.createElement('div'), css = 'top:0; left:0; position:absolute; z-index:99999; visibility:hidden'; div.style.cssText = css; div.setAttribute('style', css); var sug = document.createElement('div'), css = 'font:normal 12px/16px "宋体"; white-space:nowrap; color:#666; padding:3px; position:absolute; left:0; top:0; z-index:10; background:#f9fdfd; border:1px solid #0aa'; sug.style.cssText = css; sug.setAttribute('style', css); var dr = document.createElement('div'), css = 'position:absolute; top:3px; left:3px; background:#333; filter:alpha(opacity=50); opacity:0.5; z-index:9'; dr.style.cssText = css; dr.setAttribute('style', css); var ifr = document.createElement('iframe'), css = 'position:absolute; left:0; top:0; z-index:8; filter:alpha(opacity=0); opacity:0'; ifr.style.cssText = css; ifr.setAttribute('style', css); div.appendChild(ifr); div.appendChild(dr); div.appendChild(sug); div.sug = sug; document.body.appendChild(div); oThis.sug = div; oThis.dr = dr; oThis.ifr = ifr; div = dr = ifr = sug = null; } var e = e || window.event, obj = oThis.sug, dr = oThis.dr, ifr = oThis.ifr; obj.sug.innerHTML = str; var w = obj.sug.offsetWidth, h = obj.sug.offsetHeight, dw = document.documentElement.clientWidth || document.body.clientWidth; dh = document.documentElement.clientHeight || document.body.clientHeight; var st = document.documentElement.scrollTop || document.body.scrollTop, sl = document.documentElement.scrollLeft || document.body.scrollLeft; var left = e.clientX + sl + 17 + w < dw + sl && e.clientX + sl + 15 || e.clientX + sl - 8 - w, top = e.clientY + st + 17 + h < dh + st && e.clientY + st + 17 || e.clientY + st - 5 - h; obj.style.left = left + 10 + 'px'; obj.style.top = top + 10 + 'px'; dr.style.width = w + 'px'; dr.style.height = h + 'px'; ifr.style.width = w + 3 + 'px'; ifr.style.height = h + 3 + 'px'; obj.style.visibility = 'visible'; document.onmousemove = function (e) { var e = e || window.event, st = document.documentElement.scrollTop || document.body.scrollTop, sl = document.documentElement.scrollLeft || document.body.scrollLeft; var left = e.clientX + sl + 17 + w < dw + sl && e.clientX + sl + 15 || e.clientX + sl - 8 - w, top = e.clientY + st + 17 + h < dh + st && e.clientY + st + 17 || e.clientY + st - 5 - h; obj.style.left = left + 'px'; obj.style.top = top + 'px'; } } </script> <script src="/Scripts/layer/layer.min.js"></script> </html>

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