The Applications of Biomarkers in Digital Pathology and Personalised Medicine

<!doctype html><html lang="en"><head> <meta charset="utf-8"> <title>The Applications of Biomarkers in Digital Pathology and Personalised Medicine</title> <link rel="shortcut icon" href="https://oxfordglobal.com/hubfs/OXFORD_GLOBAL-LOGO_SYMBOL.jpg"> <meta name="description" content="New breakthroughs for biomarkers in digital pathology could assist in the identification of health indicators similar to HER2 and MSI."> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta property="og:description" content="New breakthroughs for biomarkers in digital pathology could assist in the identification of health indicators similar to HER2 and MSI."> <meta property="og:title" content="The Applications of Biomarkers in Digital Pathology and Personalised Medicine"> <meta name="twitter:description" content="New breakthroughs for biomarkers in digital pathology could assist in the identification of health indicators similar to HER2 and MSI."> <meta name="twitter:title" content="The Applications of Biomarkers in Digital Pathology and Personalised Medicine"> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://oxfordglobal.com/hs-fs/hub/8696823/hub_generated/template_assets/135726131582/1732113079147/git/og-stage/css/main.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/fontawesome.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/brands.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/solid.min.css">  <style id="hs_editor_style" type="text/css"> #hs_cos_wrapper_module_17019620504109 { display: block !important; margin-bottom: 0px !important } </style>  <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; if (!window._hsGoogleConsentRunOnce) { window._hsGoogleConsentRunOnce = true; gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); if (useGoogleConsentModeV2) { _hsp.push(['useGoogleConsentModeV2']) } else { _hsp.push(['addPrivacyConsentListener', function(consent){ var hasAnalyticsConsent = consent && (consent.allowed || (consent.categories && consent.categories.analytics)); var hasAdsConsent = consent && (consent.allowed || (consent.categories && consent.categories.advertisement)); gtag('consent', 'update', { 'ad_storage': hasAdsConsent ? 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id="main-content"> <div class="resource-single"> <div class="header bg-primary-light"> <div class="container-wrapper"> <div class="wide-container header-container"> <div class="header-content flex-1"> <div class="heading-smallcaps"> Digital Biomarkers | Industry Spotlights & Insight Articles </div> <h1 class="heading"> The Applications of Biomarkers in Digital Pathology and Personalised Medicine </h1> <div class="byline"> Edited by Ben Norris | 12 October 2023 </div> <div class="abstract"> Digital pathology could enable the integration of biomarkers to enhance therapy effectiveness, potentially improving the capabilities of pathologists through AI-powered tools. </div> </div> <div class="header-graphic flex-1"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Biomarkers/The-Applications-of-Biomarkers-in-Digital-Pathology-and-Personalised-Medicine-.jpg" class="header-graphic-image"> </div> </div> </div> </div> <div class="container-wrapper"> <div class="wide-container"> <div class="content"> <div class="content-body text-gap">  <p>To be clinically relevant, biomarkers in digital pathology must be shown to be beneficial in therapies after they have been established as valid. </p>   <p>Technological advances have facilitated the development of digital pathology-based approaches for qualitative pathologic assessments. </p>   <p>The historical role of pathology in the drug development process could be augmented accordingly. </p>   <ul> <li><strong>Related:</strong> <a href="https://oxfordglobal.com/biomarkers/resources/ai-in-digital-pathology-the-applications-of-explainable-ai-and-deep-learning-approaches-in-clinical-practice/" target="_blank" rel="noreferrer noopener">What are the applications of explainable AI in clinical practice?</a></li> </ul>   <p></p>   <p>In the context of biomarkers in digital pathology, the parameters must meet the definition of a biomarker as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention.</p>   <p>Digital pathology is being actively developed accordingly to mitigate issues posed by the increased volume and complexity of histopathological workflows. </p>   <p>Many clinical workflows in oncology rely on predictive or prognostic molecular biomarkers, but the growing number of complex biomarkers – multidimensional health indicators observed together – ups the cost and time involved in decision-making. </p>   <h2 class="wp-block-heading" id="h-opportunities-for-biomarkers-in-digital-pathology"><strong>Opportunities for Biomarkers in Digital Pathology</strong></h2>   <p>At present, molecular biomarkers in oncology workflows can be prognostic or predictive, allowing for an adjustment of treatment intensity accordingly. </p>   <p>As one example of an area of expansion for biomarkers in digital pathology, they can be applied to stage II colorectal cancer, where microsatellite instability (MSI) is a prognostic biomarker. </p>   <p>If MSI is detected, a lower treatment intensity of adjuvant chemotherapy can be used since the treatment prognosis for these patients is typically much better. </p>   <ul> <li><strong>Related:</strong> <a href="https://oxfordglobal.com/biomarkers/resources/digital-biomarkers-using-smartphones-for-the-passive-monitoring-of-neurodegenerative-diseases/" target="_blank" rel="noreferrer noopener">Passively monitoring biomarkers using smartphones</a></li> </ul>   <p></p>   <p>By contrast, predictive biomarkers enable a particular targeted treatment to be chosen for a specific patient group. </p>   <p>Similarly, in the context of breast cancer, the detection of HER2 positivity makes patients eligible for treatment with anti-HER2 agents, acting as a strong predictive biomarker in this disease.</p>   <p>Integration of biomarkers in digital pathology for these approaches would help considerably for biomarker identification and analysis, with automated pathology workflows able to facilitate the detection, grading, and subtyping of tumour tissue in histology images. </p>   <h2 class="wp-block-heading"><strong>Future Applications and Predictions </strong></h2>   <p>Despite the numerous advantages of biomarkers in digital pathology, the approach is not the easiest to adopt into clinical practice. </p>   <p>It is necessary to prove whether diagnostic and classification algorithms using digital pathology are useful in clinical practices before they can be adopted. </p>   <ul> <li><strong>Related:</strong> <a href="https://oxfordglobal.com/biomarkers/resources/identifying-prognostic-biomarkers-for-follicular-lymphoma/" target="_blank" rel="noreferrer noopener">Identifying biomarkers for follicular lymphoma via digital pathology</a></li> </ul>   <p></p>   <p>In years to come, the traditional role of pathologists in delivering accurate diagnoses or assessing biomarkers for companion diagnostics may be enhanced in precision, reproducibility, and scale through AI-powered tools. </p>   <p><em>Get your weekly 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To learn more about our upcoming Precision Oncology Europe conference, </em><a href="https://oxfordglobal.com/precision-oncology/" target="_blank" rel="noreferrer noopener"><em>visit our event website</em></a><em> to download an agenda and register your interest.</em></p>  <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/precision-medicine/resources/world-stroke-day-spotlight-the-role-of-wearable-technology-in-stroke-rehabilitation"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Biomarkers/World%20Stroke%20Day%20Spotlight%20The%20Role%20of%20Wearable%20Technology%20in%20Stroke%20Rehabilitation.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/precision-medicine/resources/world-stroke-day-spotlight-the-role-of-wearable-technology-in-stroke-rehabilitation"> <h4> World Stroke Day Spotlight: The Role of Wearable Technology in Stroke Rehabilitation </h4> <div class="abstract"> To mark World Stroke Day, this article explores innovative research in stroke rehabilitation and treatment. 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The Applications of Biomarkers in Digital Pathology and Personalised Medicine