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Please update your browser bookmarks and please use the default browser print function instead.</div></div><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <style data-mw-deduplicate="TemplateStyles:r1251242444">.mw-parser-output .ambox{border:1px solid #a2a9b1;border-left:10px solid #36c;background-color:#fbfbfb;box-sizing:border-box}.mw-parser-output .ambox+link+.ambox,.mw-parser-output .ambox+link+style+.ambox,.mw-parser-output .ambox+link+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+style+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+link+.ambox{margin-top:-1px}html body.mediawiki .mw-parser-output .ambox.mbox-small-left{margin:4px 1em 4px 0;overflow:hidden;width:238px;border-collapse:collapse;font-size:88%;line-height:1.25em}.mw-parser-output .ambox-speedy{border-left:10px solid #b32424;background-color:#fee7e6}.mw-parser-output .ambox-delete{border-left:10px solid #b32424}.mw-parser-output .ambox-content{border-left:10px solid #f28500}.mw-parser-output .ambox-style{border-left:10px solid #fc3}.mw-parser-output .ambox-move{border-left:10px solid #9932cc}.mw-parser-output .ambox-protection{border-left:10px solid #a2a9b1}.mw-parser-output .ambox .mbox-text{border:none;padding:0.25em 0.5em;width:100%}.mw-parser-output .ambox .mbox-image{border:none;padding:2px 0 2px 0.5em;text-align:center}.mw-parser-output .ambox .mbox-imageright{border:none;padding:2px 0.5em 2px 0;text-align:center}.mw-parser-output .ambox .mbox-empty-cell{border:none;padding:0;width:1px}.mw-parser-output .ambox .mbox-image-div{width:52px}@media(min-width:720px){.mw-parser-output .ambox{margin:0 10%}}@media print{body.ns-0 .mw-parser-output .ambox{display:none!important}}</style><table class="box-Circular plainlinks metadata ambox ambox-content ambox-Unreferenced" role="presentation"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><a href="/wiki/File:Question_book-new.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/en/thumb/9/99/Question_book-new.svg/50px-Question_book-new.svg.png" decoding="async" width="50" height="39" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/99/Question_book-new.svg/75px-Question_book-new.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/9/99/Question_book-new.svg/100px-Question_book-new.svg.png 2x" data-file-width="512" data-file-height="399" /></a></span></div></td><td class="mbox-text"><div class="mbox-text-span">This article <b>cites Wikipedia (or sources that take information from Wikipedia) in a <a href="/wiki/Wikipedia:Verifiability#Wikipedia_and_sources_that_mirror_or_use_it" title="Wikipedia:Verifiability">circular manner</a></b>.<span class="hide-when-compact"> Please help <a class="external text" href="https://en.wikipedia.org/w/index.php?title=C14orf119&action=edit">improve this article</a> by <a href="/wiki/Wikipedia:Copying_within_Wikipedia#Repairing_insufficient_attribution" title="Wikipedia:Copying within Wikipedia">repairing any insufficient attribution</a> if necessary and adding citations to <a href="/wiki/Wikipedia:Reliable_sources" title="Wikipedia:Reliable sources">reliable sources</a>. Unsourced or poorly sourced material may be challenged and <a href="/wiki/Wikipedia:Verifiability#Burden_of_evidence" title="Wikipedia:Verifiability">removed</a>.<br /><small><span class="plainlinks"><i>Find sources:</i> <a rel="nofollow" class="external text" href="https://www.google.com/search?as_eq=wikipedia&q=%22C14orf119%22">"C14orf119"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22C14orf119%22+-wikipedia&tbs=ar:1">news</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22C14orf119%22&tbs=bkt:s&tbm=bks">newspapers</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22C14orf119%22+-wikipedia">books</a> <b>·</b> <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22C14orf119%22">scholar</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22C14orf119%22&acc=on&wc=on">JSTOR</a></span></small></span> <span class="date-container"><i>(<span class="date">May 2020</span>)</i></span><span class="hide-when-compact"><i> (<small><a href="/wiki/Help:Maintenance_template_removal" title="Help:Maintenance template removal">Learn how and when to remove this message</a></small>)</i></span></div></td></tr></tbody></table> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">C14orf119</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/20270">C14orf119</a></span>, chromosome 14 open reading frame 119</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1920893">1920893</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=9921">9921</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=C14orf119">C14orf119</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000179933">C14orf119 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_14.svg" class="mw-file-description" title="Chromosome 14 (human)"><img alt="Chromosome 14 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/Ideogram_human_chromosome_14.svg/300px-Ideogram_human_chromosome_14.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/Ideogram_human_chromosome_14.svg/450px-Ideogram_human_chromosome_14.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/78/Ideogram_human_chromosome_14.svg/600px-Ideogram_human_chromosome_14.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_14_(human)" class="mw-redirect" title="Chromosome 14 (human)">Chromosome 14 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_14_ideogram.svg" class="mw-file-description" title="Chromosome 14 (human)"><img alt="Chromosome 14 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Human_chromosome_14_ideogram.svg/300px-Human_chromosome_14_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Human_chromosome_14_ideogram.svg/450px-Human_chromosome_14_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Human_chromosome_14_ideogram.svg/600px-Human_chromosome_14_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 58.068301035682px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for C14orf119"><img alt="Genomic location for C14orf119" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 64.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for C14orf119"><img alt="Genomic location for C14orf119" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">14q11.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">23,095,505 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">23,100,456 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_14.svg" class="mw-file-description" title="Chromosome 14 (mouse)"><img alt="Chromosome 14 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/Ideogram_house_mouse_chromosome_14.svg/260px-Ideogram_house_mouse_chromosome_14.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/Ideogram_house_mouse_chromosome_14.svg/390px-Ideogram_house_mouse_chromosome_14.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e5/Ideogram_house_mouse_chromosome_14.svg/520px-Ideogram_house_mouse_chromosome_14.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 14 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_14.svg" class="mw-file-description" title="Chromosome 14 (mouse)"><img alt="Chromosome 14 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Ideogram_of_house_mouse_chromosome_14.svg/300px-Ideogram_of_house_mouse_chromosome_14.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Ideogram_of_house_mouse_chromosome_14.svg/450px-Ideogram_of_house_mouse_chromosome_14.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Ideogram_of_house_mouse_chromosome_14.svg/600px-Ideogram_of_house_mouse_chromosome_14.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 123.94548374974px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for C14orf119"><img alt="Genomic location for C14orf119" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 129.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for C14orf119"><img alt="Genomic location for C14orf119" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">14|14 C2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">54,923,673 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">54,928,198 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000179933">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">mucosa of ileum</li><br /><li style="line-height: 137%;">stromal cell of endometrium</li><br /><li style="line-height: 137%;">mucosa of sigmoid colon</li><br /><li style="line-height: 137%;">islet of Langerhans</li><br /><li style="line-height: 137%;">smooth muscle tissue</li><br /><li style="line-height: 137%;">rectum</li><br /><li style="line-height: 137%;">decidua</li><br /><li style="line-height: 137%;">oocyte</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">right adrenal cortex</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000040822">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">olfactory epithelium</li><br /><li style="line-height: 137%;">medullary collecting duct</li><br /><li style="line-height: 137%;">primitive streak</li><br /><li style="line-height: 137%;">otic placode</li><br /><li style="line-height: 137%;">abdominal wall</li><br /><li style="line-height: 137%;">medial ganglionic eminence</li><br /><li style="line-height: 137%;">endocardial cushion</li><br /><li style="line-height: 137%;">fossa</li><br /><li style="line-height: 137%;">condyle</li><br /><li style="line-height: 137%;">efferent ductule</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000179933">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=55017&rn=1">55017</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=58248&rn=1">58248</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000179933;db=core">ENSG00000179933</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000040822;db=core">ENSMUSG00000040822</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9NWQ9">Q9NWQ9</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9JJ93">Q9JJ93</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_017924">NM_017924</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_021437">NM_021437</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_060394">NP_060394</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_067412">NP_067412</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr14:23095505-23100456">Chr 14: 23.1 – 23.1 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr14:54923673-54928198">Chr 14: 54.92 – 54.93 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18041479" class="extiw" title="d:Q18041479">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18258875" class="extiw" title="d:Q18258875">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>C14orf119</b> is a protein that in humans is encoded by the <i>c14orf119</i> gene. The c14orf119 protein is predicted to be localized in the nucleus.<sup id="cite_ref-:0_5-0" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Additionally, c14orf119 expression is decreased in individuals with <a href="/wiki/Lupus" title="Lupus">systemic lupus erythematosus (SLE)</a> when compared with healthy individual and is increased in individuals with various types of <a href="/wiki/Lymphoma" title="Lymphoma">lymphomas</a> when compared to healthy individuals.<sup id="cite_ref-:10_6-0" class="reference"><a href="#cite_note-:10-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:11_7-0" class="reference"><a href="#cite_note-:11-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2></div> <p>The common aliases of c14orf119 are chromosome <a href="/wiki/Open_reading_frame" title="Open reading frame">open reading frame</a> 119 and My028.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> The gene is located on chromosome 14, with the specific location of 14q11.2.<sup id="cite_ref-:8_9-0" class="reference"><a href="#cite_note-:8-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> It contains two exons and covers 5.76 kb, from 23563900 to 23569660 on the forward strand.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The span of the c14orf119 gene, from the start of transcription to the polyA site, is 4951 basepairs in length.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Transcripts">Transcripts</h2></div> <p>The c14orf119 mRNA is composed of 2914 basepairs.<sup id="cite_ref-:8_9-1" class="reference"><a href="#cite_note-:8-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> C14orf119 has two isoforms, shown in the table below. </p> <table class="wikitable"> <caption>C14orf119 Isoforms<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Name </th> <th>Accession Number<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></th> <th>Transcript ID</th> <th>Length </th></tr> <tr> <td>C14orf119-201 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/nuccore/NM_017924.4">NM_017924.4</a> </td> <td><a rel="nofollow" class="external text" href="http://useast.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000179933;r=14:23095505-23100456;t=ENST00000319074">ENST00000319074.6</a></td> <td>2914 nt </td></tr> <tr> <td>C14orf119-202 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/nuccore/XM_017021390.2">XM_017021390.2</a> </td> <td><a rel="nofollow" class="external text" href="http://useast.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000179933;r=14:23095505-23100456;t=ENST00000554203">ENST00000554203.1</a></td> <td>725 nt </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Protein">Protein</h2></div> <p>The c14orf119 protein is composed of 140 amino acids.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> The molecular weight of the c14orf119 protein is approximately 16 kDa and the basal isoelectric point is 4.86.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> There is a long section of hydrophobic amino acids at the start of the protein.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> There are no additional significant compositional features of the c14orf119 protein, including charge clusters, charge runs, patterns, repetitive structures or multiplets.<sup id="cite_ref-:7_17-0" class="reference"><a href="#cite_note-:7-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> The primary sequence of the c14orf119 protein is as follows, </p><p>MPLESSSSMP LSFPSLLPSV PHNTNPSPPL MSYITSQEMK CILHWFANWS GPQRERFLED LVAKAVPEKL </p><p>QPLLDSLEQL SVSGADRPPS IFECQLHLWD QWFRGWAEQE RNEFVRQLEF SEPDFVAKFY QAVAATAGKD<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p><p>There are two known c14orf119 protein isoforms, as shown in the table below. </p> <table class="wikitable"> <caption>C14orf119 Protein Isoforms<sup id="cite_ref-:4_19-0" class="reference"><a href="#cite_note-:4-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Name </th> <th>Accession Number </th> <th>Size </th> <th>Domain Inclusion </th></tr> <tr> <td>Uncharacterized c14orf119 protein </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_060394.1">NP_060394.1</a> </td> <td>140 aa </td> <td>DUF4508 </td></tr> <tr> <td>Uncharacterized c14orf119 protein isoform X1 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_016876879.1">XP_016876879.1</a> </td> <td>140 aa </td> <td>DUF4508 </td></tr></tbody></table> <div class="mw-heading mw-heading3"><h3 id="Domains_and_motifs">Domains and motifs</h3></div> <p>There is a domain of unknown function (DUF) found in the c14orf119 protein: DUF4508 (with an E-value of 6.3e-36).<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> This DUF is a part of a family of proteins that is found in eukaryotes and is typically between 117 and 253 amino acids in length.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Additionally, there are three predicted CK2 phosphorylation sites (at positions 36, 83, and 121) within the c14orf119 protein.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:C14orf119Phyre2.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/21/C14orf119Phyre2.png/220px-C14orf119Phyre2.png" decoding="async" width="220" height="251" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/21/C14orf119Phyre2.png/330px-C14orf119Phyre2.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/21/C14orf119Phyre2.png/440px-C14orf119Phyre2.png 2x" data-file-width="537" data-file-height="612" /></a><figcaption><b>Figure 1.</b> Phyre2 predicted secondary structure of the c14orf119 protein.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup></figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Secondary_structure">Secondary structure</h3></div> <p>The predicted <a href="/wiki/Protein_secondary_structure" title="Protein secondary structure">secondary structure</a> of the c14orf119 protein is largely alpha helical in content. The specific makeup of the secondary structure is as follows, <a href="/wiki/Alpha_helix" title="Alpha helix">alpha helices</a> make up 38.57% of the protein (54 amino acids), extended strands make up 23.57% of the protein (33 amino acids), and random coils make up 37.86% of the protein (53 amino acids).<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> Phryre2, a program for protein modeling, prediction, and analysis, was used to determine and model the predicted structure of the c14orf119 protein.<sup id="cite_ref-:3_25-0" class="reference"><a href="#cite_note-:3-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> Shown in Figure 1, Phyre2 created a model for the predicted structure of 106 (out of a total of 140) residues of the c14orf119 protein, with 79.7% confidence and 76% coverage.<sup id="cite_ref-:3_25-1" class="reference"><a href="#cite_note-:3-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Tertiary_and_quaternary_structures">Tertiary and quaternary structures</h3></div> <p>With only two cysteines, 52 amino acids apart, found in the c14orf119 protein sequence, there were no predicted <a href="/wiki/Disulfide" title="Disulfide">disulfide bonds</a> in the c14orf119 protein.<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:7_17-1" class="reference"><a href="#cite_note-:7-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> There are no predicted transmembrane regions or signal peptides in the c14orf119 protein.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Gene_level_regulation">Gene level regulation</h2></div> <div class="mw-heading mw-heading3"><h3 id="Promoter">Promoter</h3></div> <p>The predicted promoter sequence associated with c14orf119 is 3332 bases in length.<sup id="cite_ref-:6_30-0" class="reference"><a href="#cite_note-:6-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> This promoter sequence has one CpG island associated with it, with a CpG count of 78<sup id="cite_ref-:6_30-1" class="reference"><a href="#cite_note-:6-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> Additionally, there are a number of transcription factor binding sites associated with this promoter sequence, such as <a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">RB1</a>, <a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">HNF4A</a>, <a href="/wiki/ETS1" title="ETS1">ETS1</a>, and <a href="/wiki/Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a>.<sup id="cite_ref-:1_31-0" class="reference"><a href="#cite_note-:1-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Expression_pattern">Expression pattern</h3></div> <p>C14orf119 is expressed in 203 organs.<sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> The c14orf119 gene is expressed in a number of tissues and has the highest expression rates in cultured fibroblast cells, with a TPM of 75.63.<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> There is notable decreased expression of c14orf119 in the following tissues, pancreas, bone marrow, brain, salivary glands, and the liver.<sup id="cite_ref-:4_19-1" class="reference"><a href="#cite_note-:4-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> Additionally, there is notable increased expression of c14orf119 in the adrenal gland, kidney, lung, prostate, thymus, white blood cells, lymph node, and thyroid.<sup id="cite_ref-:4_19-2" class="reference"><a href="#cite_note-:4-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> Finally, expression levels of c14orf119 decrease with the development of the kidney and increases with development of the stomach.<sup id="cite_ref-:4_19-3" class="reference"><a href="#cite_note-:4-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Transcript_level_regulation">Transcript level regulation</h2></div> <p>There were no predicted enhancers associated with c14orf119.<sup id="cite_ref-:1_31-1" class="reference"><a href="#cite_note-:1-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> There were a number of stem loop formation predictions in both the 5' UTR and 3' UTR of c14orf119.<sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="miRNA_targeting">miRNA targeting</h3></div> <p>The miRNA binding sites found in the 3' UTR of c14orf119 include miR-489, miR-1872, and miR-4778-3p; however, there were no miRNA binding sites found in the 5' UTR of c14orf119.<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Protein_level_regulation">Protein level regulation</h2></div> <div class="mw-heading mw-heading3"><h3 id="Subcellular_localization">Subcellular localization</h3></div><p> The c14orf119 protein is predicted to be located in the nucleus, with a reliability score of 55.5.<sup id="cite_ref-:0_5-1" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> However, the protein has a 7.9% basic residue content and a nuclear localization signal (NLS) score of -0.47.<sup id="cite_ref-:5_37-0" class="reference"><a href="#cite_note-:5-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> Additionally, there was a predicted ER retention motif at positions 136-139 of the protein.<sup id="cite_ref-:5_37-1" class="reference"><a href="#cite_note-:5-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> Finally, there were no N-terminal signal peptides, no cleavage sites for mitochondria, no actinin-type actin-binding motifs, and no N-myristolyation pattern.<sup id="cite_ref-:0_5-2" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><figure typeof="mw:File/Thumb"><a href="/wiki/File:C14orf119conceptualtranslation.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/C14orf119conceptualtranslation.png/534px-C14orf119conceptualtranslation.png" decoding="async" width="534" height="490" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/f/f2/C14orf119conceptualtranslation.png 1.5x" data-file-width="730" data-file-height="670" /></a><figcaption><b>Figure 2.</b> Conceptual translation of c14orf119, which reveals predicted post-translational modifications.<sup id="cite_ref-:12_38-0" class="reference"><a href="#cite_note-:12-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:13_39-0" class="reference"><a href="#cite_note-:13-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:14_40-0" class="reference"><a href="#cite_note-:14-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:15_41-0" class="reference"><a href="#cite_note-:15-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:16_42-0" class="reference"><a href="#cite_note-:16-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:17_43-0" class="reference"><a href="#cite_note-:17-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup></figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Post-translational_modifications">Post-translational modifications</h3></div> <p>There are a number of post-translational modifications of the c14orf119 protein, all of which are shown on the conceptual translation of c14orf119 in Figure 2. </p><p>There are predicted ubiquitination sites at lysine residues at positions 128 and 139.<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> </p><p>There are predicted kinase-specific phosphorylation sites at serines at the following position in the c14orf119 protein sequence, 15, 19, 27, 32, 36, 81, 83, 90, and 121.<sup id="cite_ref-:17_43-1" class="reference"><a href="#cite_note-:17-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-45" class="reference"><a href="#cite_note-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> Protein phosphorylation at serine residues can play critical roles in the regulation of protein function and the transmission of signals throughout the cell.<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> </p><p>There are two N-glycosylation sites at positions 25-27 and 48–50.<sup id="cite_ref-:16_42-1" class="reference"><a href="#cite_note-:16-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> This type of post-translational modification plays important roles in both the structure and function of some eukaryotic proteins. </p><p>Additionally, there are predicted glycation of epsilon amino groups of lysines at the following positions, 40, 64, 69, and 139.<sup id="cite_ref-:15_41-1" class="reference"><a href="#cite_note-:15-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> Glycation is a process in which proteins react with reducing sugar molecules, which ultimately impairs the function and changes the characteristics of the protein.<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </p><p>There are also predicted mammalian mucin type GalNAc-O-glycosylation sites at the following positions, 5, 6, 7, 12, 15, 19, and 24.<sup id="cite_ref-:14_40-1" class="reference"><a href="#cite_note-:14-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> GalNAc-type-O-glycosylation is the attachment of a sugar molecule to the oxygen atom of serine or threonine residues in a protein.<sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> O-glycans or the sugars added to the serine or threonine, have various functions, including allowing recognition of foreign material, providing cartilage and tendon flexibility, controlling cell metabolism, and trafficking cells in the immune system.<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> </p><p>There is a predicted SUMOylation sites at the lysine at position 139.<sup id="cite_ref-:13_39-1" class="reference"><a href="#cite_note-:13-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> SUMOylation is involved in transcriptional regulation, protein stability, apoptosis, nuclear-cytosolic transport, progression through the cell cycle, and response to stress.<sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup> </p><p>Finally, there are predicted O-GlcNAc sites at the serines at the following position in the c14orf119 protein, 5, 6, 7, 8, and 83.<sup id="cite_ref-:12_38-1" class="reference"><a href="#cite_note-:12-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> This post-translational modification can play various critical roles such as, progression through the cell cycle, response to cellular stress, protein turnover, and protein stability.<sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Regulation_of_expression">Regulation of expression</h2></div> <div class="mw-heading mw-heading3"><h3 id="Epigenetic">Epigenetic</h3></div><p> There are varying levels of H3K27ac, H3K4me1, and H3K4me3 throughout the c14orf119 gene.<sup id="cite_ref-:1_31-2" class="reference"><a href="#cite_note-:1-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> H3K4me1 has variation in signal strength among different cell lines, which may reflect differences of epigenetic landscapes in these cell lines.<sup id="cite_ref-:1_31-3" class="reference"><a href="#cite_note-:1-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> Additionally, there is a strong signal of H3K27ac across the majority of cell lines along the predicted promoter region.<sup id="cite_ref-:1_31-4" class="reference"><a href="#cite_note-:1-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> Finally, there is also a strong signal of H3K4me3 across the majority of the cell types along the predicted promoter region, with no signal variation across cell types.<sup id="cite_ref-:1_31-5" class="reference"><a href="#cite_note-:1-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p><figure typeof="mw:File/Thumb"><a href="/wiki/File:C14orf119graph.png" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/02/C14orf119graph.png/634px-C14orf119graph.png" decoding="async" width="634" height="264" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/02/C14orf119graph.png/951px-C14orf119graph.png 1.5x, //upload.wikimedia.org/wikipedia/commons/0/02/C14orf119graph.png 2x" data-file-width="1091" data-file-height="454" /></a><figcaption><b>Figure 3.</b> Date of divergence graph for c14orf119, with comparison to hemoglobin, fibrinogen alpha chain, and cytochrome c. </figcaption></figure> <div class="mw-heading mw-heading2"><h2 id="Homology/evolution"><span id="Homology.2Fevolution"></span>Homology/evolution</h2></div> <p>C14orf119 is conserved in both vertebrates and invertebrates, however, it is not conserved in bacteria, archaea, trichoplax, plants or fungi.<sup id="cite_ref-:9_52-0" class="reference"><a href="#cite_note-:9-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> The c14orf119 gene is highly conserved in the mammalian orthologs, however, within the non-mammalian orthologs, there are various insertions, especially at the beginning and end of the gene.<sup id="cite_ref-:9_52-1" class="reference"><a href="#cite_note-:9-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> This gene does not contain any paralogs or paralogous domains.<sup id="cite_ref-:9_52-2" class="reference"><a href="#cite_note-:9-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> </p><p>As shown in Figure 3, the c14orf119 gene has evolved moderately quickly when compared to cytochrome c, fibrinogen alpha chain, and hemoglobin. It has evolved faster than both hemoglobin and cytochrome c, but slower than fibrinogen alpha chain. </p><p>The table below reveals the various orthologs of the c14orf119 protein. This table includes the date of divergence (DoD) from humans, in million years ago (MYA), accession number, and percent identity and similarity to humans for each ortholog. </p> <table class="wikitable"> <caption>C14orf119 Orthologs </caption> <tbody><tr> <th>Genus and Species </th> <th>Common Name </th> <th>Taxonomy - Class </th> <th>Taxonomy - Order </th> <th>DoD (MYA) </th> <th>Accession Number </th> <th>Sequence Length (aa) </th> <th>Percent Identity </th> <th>Percent Similarity </th></tr> <tr> <td><i><a href="/wiki/Homo_sapiens" class="mw-redirect" title="Homo sapiens">Homo sapiens</a></i> </td> <td>Human </td> <td>Mammalia </td> <td>Primates </td> <td>0 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_060394.1">NP_060394.1</a> </td> <td>140 </td> <td>100 </td> <td>100 </td></tr> <tr> <td><i><a href="/wiki/House_mouse" title="House mouse">Mus musculus</a></i> </td> <td>Mouse </td> <td>Mammalia </td> <td>Rodentia </td> <td>89 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_067412.1">NP_067412.1</a> </td> <td>142 </td> <td>83.1 </td> <td>90.1 </td></tr> <tr> <td><i><a href="/wiki/Brandt%27s_bat" title="Brandt's bat">Myotis brandtii</a></i> </td> <td>Brandt's Bat </td> <td>Mammalia </td> <td>Chiroptera </td> <td>94 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_005852873.1">XP_005852873.1</a> </td> <td>141 </td> <td>86.5 </td> <td>90.8 </td></tr> <tr> <td><i><a href="/wiki/Northern_fur_seal" title="Northern fur seal">Callorhinus ursinus</a></i> </td> <td>Northern Fur Seal </td> <td>Mammalia </td> <td>Carnivora </td> <td>94 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_025726115.1">XP_025726115.1</a> </td> <td>142 </td> <td>88 </td> <td>91.5 </td></tr> <tr> <td><i><a href="/wiki/Cattle" title="Cattle">Bos taurus</a></i> </td> <td>Cattle </td> <td>Mammalia </td> <td>Artiodactyla </td> <td>94 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_002690553.1">XP_002690553.1</a> </td> <td>142 </td> <td>88 </td> <td>92.3 </td></tr> <tr> <td><i><a href="/wiki/Aardvark" title="Aardvark">Orycteropus afer afer</a></i> </td> <td>Aardvark </td> <td>Mammalia </td> <td>Tubulidentata </td> <td>102 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_007949377.1">XP_007949377.1</a> </td> <td>140 </td> <td>85.1 </td> <td>89.4 </td></tr> <tr> <td><i><a href="/wiki/Burmese_python" title="Burmese python">Python bivittatus</a></i> </td> <td>Burmese Python </td> <td>Reptilia </td> <td>Squamata </td> <td>318 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_007441564.1">XP_007441564.1</a> </td> <td>156 </td> <td>47.8 </td> <td>60.2 </td></tr> <tr> <td><i><a href="/wiki/Podarcis_muralis" title="Podarcis muralis">Podarcia muralis</a></i> </td> <td>Common Wall Lizard </td> <td>Reptilia </td> <td>Squamata </td> <td>318 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_028559108.1">XP_028559108.1</a> </td> <td>115 </td> <td>51.8 </td> <td>63.8 </td></tr> <tr> <td><i><a href="/wiki/Nanorana_parkeri" title="Nanorana parkeri">Nanorana parkeri</a></i> </td> <td>High Himalaya Frog </td> <td>Amphibia </td> <td>Anura </td> <td>351.7 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_018411628.1">XP_018411628.1</a> </td> <td>115 </td> <td>45.7 </td> <td>60.7 </td></tr> <tr> <td><i><a href="/wiki/Larimichthys_crocea" title="Larimichthys crocea">Larimichthys crocea</a></i> </td> <td>Marine Fish </td> <td>Actinopterygii </td> <td>Perciformes </td> <td>433 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_010740478.3">XP_010740478.3</a> </td> <td>201 </td> <td>34.5 </td> <td>44.3 </td></tr> <tr> <td><i><a href="/wiki/Small_hive_beetle" title="Small hive beetle">Aethina tumida</a></i> </td> <td>Small Hive Beetle </td> <td>Insecta </td> <td>Coleoptera </td> <td>736 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_019869014.1">XP_019869014.1</a> </td> <td>124 </td> <td>18.6 </td> <td>39.7 </td></tr> <tr> <td><i><a href="/wiki/Bombus_terrestris" title="Bombus terrestris">Bombus terrestris</a></i> </td> <td>Buff-Tailed Bumblebee </td> <td>Insecta </td> <td>Hymenoptera </td> <td>736 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_020718687.1">XP_020718687.1</a> </td> <td>125 </td> <td>19 </td> <td>36.1 </td></tr> <tr> <td><i><a href="/wiki/Photinus_pyralis" title="Photinus pyralis">Photinus pyraliis</a></i> </td> <td>Common Eastern Firefly </td> <td>Insecta </td> <td>Coleoptera </td> <td>736 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_031358233.1">XP_031358233.1</a> </td> <td>128 </td> <td>19.9 </td> <td>40.4 </td></tr> <tr> <td><i><a href="/wiki/Pieris_rapae" title="Pieris rapae">Pieris rapae</a></i> </td> <td>Cabbage White Butterfly </td> <td>Insecta </td> <td>Lepidoptera </td> <td>736 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_022116245.1">XP_022116245.1</a> </td> <td>180 </td> <td>20 </td> <td>38.4 </td></tr> <tr> <td><i><a href="/wiki/Nasonia_vitripennis" title="Nasonia vitripennis">Nasonia vitripennis</a></i> </td> <td>Small Parasitoid Wasp </td> <td>Insecta </td> <td>Hymenoptera </td> <td>736 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_031785555.1">XP_031785555.1</a> </td> <td>121 </td> <td>22.4 </td> <td>42.1 </td></tr> <tr> <td><i><a href="/wiki/Biomphalaria_glabrata" title="Biomphalaria glabrata">Biomphalaria glabrata</a></i> </td> <td>Freshwater Snail </td> <td>Gastropoda </td> <td>Basommatophora </td> <td>736 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_013090201.1">XP_013090201.1</a> </td> <td>113 </td> <td>31.7 </td> <td>46.2 </td></tr> <tr> <td><i><a href="/wiki/California_sea_hare" title="California sea hare">Aplysia californica</a></i> </td> <td>California Seahorse </td> <td>Gastropoda </td> <td>Anaspidea </td> <td>736 </td> <td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/XP_005112416.1">XP_005112416.1</a> </td> <td>112 </td> <td>32.6 </td> <td>47.9 </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Function/biochemistry"><span id="Function.2Fbiochemistry"></span>Function/biochemistry</h2></div> <p>The function of the c14orf119 protein is not yet well understood by the scientific community. </p> <div class="mw-heading mw-heading2"><h2 id="Interacting_proteins">Interacting proteins</h2></div> <p>There are a number predicted interacting proteins found in Y2H screens, such as <a href="/wiki/XPO1" title="XPO1">exportin 1 (XPO1)</a>, <a href="/wiki/Transforming_protein_RhoA" title="Transforming protein RhoA">ras homolog family member U (RHOU)</a>, <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9BU89">deoxyhypusine hydroxylase/monooxygenase (DOHH)</a>, <a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">hepatocyte nuclear factor 4, alpha (HNF4A)</a>, <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q96BZ8">leukocyte receptor cluster member 1 (LENG1)</a>, and <a href="/wiki/Ubiquitin_C" title="Ubiquitin C">ubiquitin C (UBC)</a>.<sup id="cite_ref-53" class="reference"><a href="#cite_note-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-54" class="reference"><a href="#cite_note-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-55" class="reference"><a href="#cite_note-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2></div> <div class="mw-heading mw-heading3"><h3 id="Disease_association">Disease association</h3></div> <p>Expression of c14orf119 is decreased in individuals with <a href="/wiki/Lupus" title="Lupus">systemic lupus erythematosus (SLE)</a> when compared with healthy individuals.<sup id="cite_ref-:10_6-1" class="reference"><a href="#cite_note-:10-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Furthermore, expression of c14orf119 is increased in individuals with various types of <a href="/wiki/Lymphoma" title="Lymphoma">lymphomas</a> when compared to healthy individuals.<sup id="cite_ref-:11_7-1" class="reference"><a href="#cite_note-:11-7"><span 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a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=55017">"Human PubMed Reference:"</a>. <i>National 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href="https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS4889:223060_at">"NCBI GEO Profile for record GDS4889, c14orf119"</a>. <i>NCBI GEO</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NCBI+GEO&rft.atitle=NCBI+GEO+Profile+for+record+GDS4889%2C+c14orf119&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgeo%2Ftools%2FprofileGraph.cgi%3FID%3DGDS4889%3A223060_at&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:11-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-:11_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:11_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3516:223060_at">"NCBI GEO Profile 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Retrieved <span class="nowrap">May 3,</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=sbg.bio.ic.ac.uk&rft.atitle=Phyre+2+Results+for+c14orf119&rft_id=http%3A%2F%2Fwww.sbg.bio.ic.ac.uk%2Fphyre2%2Fphyre2_output%2F3d7e0d6c7ae74052%2Fsummary.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-24">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://npsa-prabi.ibcp.fr/cgi-bin/secpred_gor4.pl">"GOR page for c14orf119 protein"</a>. <i>GOR</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=GOR&rft.atitle=GOR+page+for+c14orf119+protein.&rft_id=https%3A%2F%2Fnpsa-prabi.ibcp.fr%2Fcgi-bin%2Fsecpred_gor4.pl&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:3-25"><span class="mw-cite-backlink">^ <a href="#cite_ref-:3_25-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:3_25-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/3d7e0d6c7ae74052/summary.html">"Phyre 2 Results for c14orf119"</a>. <i>sbg.bio.ic.ac.uk</i><span class="reference-accessdate">. Retrieved <span class="nowrap">May 1,</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=sbg.bio.ic.ac.uk&rft.atitle=Phyre+2+Results+for+c14orf119&rft_id=http%3A%2F%2Fwww.sbg.bio.ic.ac.uk%2Fphyre2%2Fphyre2_output%2F3d7e0d6c7ae74052%2Fsummary.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/Wikipedia:Link_rot" title="Wikipedia:Link rot"><span title=" Dead link tagged March 2024">permanent dead link</span></a></i><span style="visibility:hidden; color:transparent; padding-left:2px">‍</span>]</span></sup></span> </li> <li id="cite_note-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-26">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://disulfind.dsi.unifi.it/monitor.php?query=f5jIqy">"DISULFIND - Cysteines Disulfide Bonding State and Connectivity Predictor"</a>. <i>disulfind.dsi.unifi.it</i><span class="reference-accessdate">. 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Archived from <a rel="nofollow" class="external text" href="http://mendel.imp.ac.at/sat/DAS/cgi-bin/das.cgi">the original</a> on February 5, 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">May 2,</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=mendel.imp.ac.at&rft.atitle=DAS-TMfilter+prediction+results&rft_id=http%3A%2F%2Fmendel.imp.ac.at%2Fsat%2FDAS%2Fcgi-bin%2Fdas.cgi&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-29">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.cbs.dtu.dk/cgi-bin/webface2.fcgi?jobid=5EADC3D40000794ABA9A52B9&wait=20">"SignalP-5.0"</a>. <i>cbs.dtu.dk</i><span class="reference-accessdate">. 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Retrieved <span class="nowrap">May 2,</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=mirdb.org&rft.atitle=miRDB+-+MicroRNA+Target+Prediction+Database&rft_id=http%3A%2F%2Fmirdb.org%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:5-37"><span class="mw-cite-backlink">^ <a href="#cite_ref-:5_37-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:5_37-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://psort.hgc.jp/cgi-bin/runpsort.pl">"PSORT II - c14orf119"</a>. <i>PSORT II</i><span class="reference-accessdate">. Retrieved <span class="nowrap">April 28,</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=PSORT+II&rft.atitle=PSORT+II+-+c14orf119&rft_id=https%3A%2F%2Fpsort.hgc.jp%2Fcgi-bin%2Frunpsort.pl&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/Wikipedia:Link_rot" title="Wikipedia:Link rot"><span title=" Dead link tagged July 2020">permanent dead link</span></a></i><span style="visibility:hidden; color:transparent; padding-left:2px">‍</span>]</span></sup></span> </li> <li id="cite_note-:12-38"><span class="mw-cite-backlink">^ <a href="#cite_ref-:12_38-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:12_38-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.cbs.dtu.dk/cgi-bin/webface2.fcgi?jobid=5E8F5AFB000004AC7D078BFC&wait=20">"YinOYang page for c14orf119 protein"</a>. <i>YinOYang</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=YinOYang&rft.atitle=YinOYang+page+for+c14orf119+protein&rft_id=http%3A%2F%2Fwww.cbs.dtu.dk%2Fcgi-bin%2Fwebface2.fcgi%3Fjobid%3D5E8F5AFB000004AC7D078BFC%26wait%3D20&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:13-39"><span class="mw-cite-backlink">^ <a href="#cite_ref-:13_39-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:13_39-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20180506035609/http://sumosp.biocuckoo.org/showResult.php">"SUMOsp page for c14orf119 protein"</a>. <i>SUMOsp</i>. Archived from <a rel="nofollow" class="external text" href="http://sumosp.biocuckoo.org/showResult.php">the original</a> on May 6, 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">May 3,</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=SUMOsp&rft.atitle=SUMOsp+page+for+c14orf119+protein.&rft_id=http%3A%2F%2Fsumosp.biocuckoo.org%2FshowResult.php&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:14-40"><span class="mw-cite-backlink">^ <a href="#cite_ref-:14_40-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:14_40-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.cbs.dtu.dk/cgi-bin/webface2.fcgi?jobid=5E8F282400002281D099295D&wait=20">"NetOGlyc page for c14orf119 protein"</a>. <i>NetOGlyc</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NetOGlyc&rft.atitle=NetOGlyc+page+for+c14orf119+protein&rft_id=http%3A%2F%2Fwww.cbs.dtu.dk%2Fcgi-bin%2Fwebface2.fcgi%3Fjobid%3D5E8F282400002281D099295D%26wait%3D20&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:15-41"><span class="mw-cite-backlink">^ <a href="#cite_ref-:15_41-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:15_41-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.cbs.dtu.dk/cgi-bin/webface2.fcgi?jobid=5E8F258E00000BC611D5F9C1&wait=20">"NetGlycate page for c14orf119 protein"</a>. <i>NetGlycate</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NetGlycate&rft.atitle=NetGlycate+page+for+c14orf119+protein&rft_id=http%3A%2F%2Fwww.cbs.dtu.dk%2Fcgi-bin%2Fwebface2.fcgi%3Fjobid%3D5E8F258E00000BC611D5F9C1%26wait%3D20&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:16-42"><span class="mw-cite-backlink">^ <a href="#cite_ref-:16_42-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:16_42-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.cbs.dtu.dk/cgi-bin/webface2.fcgi?jobid=5EA885390000399B26EB3FB0&wait=20">"NetNGlyc - c14orf119"</a>. <i>NetNGlyc</i><span class="reference-accessdate">. Retrieved <span class="nowrap">April 28,</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NetNGlyc&rft.atitle=NetNGlyc+-+c14orf119&rft_id=http%3A%2F%2Fwww.cbs.dtu.dk%2Fcgi-bin%2Fwebface2.fcgi%3Fjobid%3D5EA885390000399B26EB3FB0%26wait%3D20&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-:17-43"><span class="mw-cite-backlink">^ <a href="#cite_ref-:17_43-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:17_43-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://gps.biocuckoo.cn/wsresult.php">"GPS page for the c14orf119 protein"</a>. <i>GPS</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=GPS&rft.atitle=GPS+page+for+the+c14orf119+protein&rft_id=http%3A%2F%2Fgps.biocuckoo.cn%2Fwsresult.php&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC14orf119" class="Z3988"></span></span> </li> <li id="cite_note-44"><span class="mw-cite-backlink"><b><a href="#cite_ref-44">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=C14orf119#transcripts">"Proteins for C14orf119 Gene"</a>. <i>GeneCards</i><span class="reference-accessdate">. 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