Researchers Map the 3D Structure of Touch Receptors and Reveal New Mechanism of Touch Detection

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Touch Detection","url":"https://medicine.yale.edu/news-article/3d-structure-touch-detection/","Image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/d6a89058-c8f8-414b-b34e-4da670d05a80","description":"3D structure of a Meissner corpuscle","height":1200,"width":630,"@context":"http://schema.org"},"dateCreated":"2023-09-13","datePublished":"2023-09-13","articleBody":"How do we detect touch? Touch is as important as vision, hearing, or smell, but of all senses, its mechanism is the one we understand the least. In a study published September 13 in Science Advances, a collaborative team of Yale researchers reveals both the 3D architecture and the mechanism of the groups of cells that act as touch detectors. Touch is known to be detected in the skin by specific groups of cells, or micro-organs, called mechanosensory corpuscles. “One of them, the Meissner corpuscle, helps us detect very fine textures and vibrations, which are very important for all aspects of everyday life,” said Slav Bagriantsev, PhD, associate professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine and co-senior author of the study together with Elena Gracheva, PhD, associate professor in the same department and of neuroscience. Meissner corpuscles contain two principal elements: lamellar cells and nerve endings. How corpuscles’ different components are organized relative to each other remained unknown. For an answer this question, the team used a cutting-edge electron microscopy technique at the Yale FIB-SEM Core. Further, Yury Nikolaev, PhD, postdoctoral fellow in Bagriantsev’s lab and co-first author of the study, used machine learning to obtain the first ever three-dimensional high-resolution structure of a Meissner corpuscle. The team revealed that, surprisingly, a single corpuscle is comprised of several lamellar cells and not one but two nerve endings. The researchers also sought to understand how the corpuscles’ different components communicate. “The overarching discovery is that lamellar cells can detect touch and then communicate that information to the nerve endings,” said Luke Ziolkowski, graduate student in the Interdepartmental Neuroscience Program and co-first author of the study. The textbooks would say that the neuronal ending is the touch detector, but what we show is that lamellar cells also contribute to touch sensation.Yury Nikolaev, PhD The team hopes to take these findings further, wondering if the bicellular mechanism of the Meissner corpuscles could be generalized to other types of touch corpuscles. “Potentially, this research will inform the development of tactile sensors for next generation of prosthetics,” said Bagriantsev. The study is one of the first large multicellular structure reconstructions using enhanced focused ion beam scanning electron microscopy (FIB-SEM). The microscopy images were collected and reconstructed in collaboration with Song Pang, MS, director of Yale FIB-SEM Core, and C. Shan Xu, PhD, professor of cellular & molecular physiology. Slav Bagriantsev, PhD, associate professor of cellular & molecular physiology, and Elena Gracheva, PhD, associate professor of neuroscience and of cellular & molecular physiology (Program in Cellular Neuroscience, Neurodegeneration and Repair, and Kavli Institute for Neuroscience), are senior authors of the study.","author":[{"@type":"Person","name":"Pauline Charbogne","@context":"http://schema.org"}],"keywords":[],"publisher":{"@type":"NewsMediaOrganization","name":"Yale School of Medicine","foundingDate":"1810-10-15","duns":"003036709","url":"https://medicine.yale.edu","logo":{"@type":"ImageObject","url":"https://medicine.yale.edu/icons/ysm/largetile.png","height":310,"width":310,"@context":"http://schema.org"},"sameAs":["https://www.facebook.com/YaleSchoolOfMedicine","https://twitter.com/YaleMed","https://www.instagram.com/yaleschoolofmed/?hl=en","https://www.linkedin.com/school/yale-university-school-of-medicine/","https://www.youtube.com/user/YaleMedicine","https://vimeo.com/user30675202"],"department":"Office of Communication","parentOrganization":{"@type":"CollegeOrUniversity","Name":"Yale University","foundingDate":"1701","duns":"043207562","url":"https://www.yale.edu/","address":{"@type":"PostalAddress","addressCountry":"USA","addressLocality":"New Haven","addressRegion":"CT","postalCode":"06520","streetAddress":"333 Cedar Street","@context":"http://schema.org"},"@context":"http://schema.org"},"@context":"http://schema.org"},"@context":"http://schema.org"} </script> <script type="text/javascript"> (function (c, a) { if (!a.__SV) { var b = window; try { var d, m, j, k = b.location, f = k.hash; d = function (a, b) { return (m = a.match(RegExp(b + "=([^&]*)"))) ? m[1] : null }; f && d(f, "fpState") && (j = JSON.parse(decodeURIComponent(d(f, "fpState"))), "fpeditor" === j.action && (b.sessionStorage.setItem("_fpcehash", f), history.replaceState(j.desiredHash || "", c.title, k.pathname + k.search))) } catch (n) { } var l, h; window.freshpaint = a; a._i = []; a.init = function (b, d, g) { function c(b, i) { var a = i.split("."); 2 == a.length && (b = b[a[0]], i = a[1]); b[i] = function () { b.push([i].concat(Array.prototype.slice.call(arguments, 0))) } } var e = a; "undefined" !== typeof g ? e = a[g] = [] : g = "freshpaint"; e.people = e.people || []; e.toString = function (b) { var a = "freshpaint"; "freshpaint" !== g && (a += "." + g); b || (a += " (stub)"); return a }; e.people.toString = function () { return e.toString(1) + ".people (stub)" }; l = "disable time_event track track_pageview track_links track_forms track_with_groups add_group set_group remove_group register register_once alias unregister identify name_tag set_config reset opt_in_tracking opt_out_tracking has_opted_in_tracking has_opted_out_tracking clear_opt_in_out_tracking people.set people.set_once people.unset people.increment people.append people.union people.track_charge people.clear_charges people.delete_user people.remove people group page alias ready addEventProperties addInitialEventProperties removeEventProperty addPageviewProperties".split(" "); for (h = 0; h < l.length; h++)c(e, l[h]); var f = "set set_once union unset remove delete".split(" "); e.get_group = function () { function a(c) { b[c] = function () { call2_args = arguments; call2 = [c].concat(Array.prototype.slice.call(call2_args, 0)); e.push([d, call2]) } } for (var b = {}, d = ["get_group"].concat(Array.prototype.slice.call(arguments, 0)), c = 0; c < f.length; c++)a(f[c]); return b }; a._i.push([b, d, g]) }; a.__SV = 1.4; b = c.createElement("script"); b.type = "text/javascript"; b.async = !0; b.src = "undefined" !== typeof FRESHPAINT_CUSTOM_LIB_URL ? 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class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pauline Charbogne</span></a></div><div class="news-details__contact"></div></div><div class="article-header__share-panel"><ul class="share-panel share-panel--horizontal"><li class="share-panel__item"><button class="share-panel__link" aria-label="Share via X" type="button"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="share-panel__icon"><path d="M17.294 22.475 1.454 1.453h5.252l15.84 21.022zm4.508-21.022-8.35 8.954M2.198 22.475l8.344-8.948" style="fill:none;stroke:currentColor;stroke-width:1.5;stroke-linecap:round;stroke-linejoin:round"></path></svg></button></li><li class="share-panel__item"><button class="share-panel__link" aria-label="Share via Facebook" type="button"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="share-panel__icon"><path 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corpuscle" video" class="poster__play-button-container"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="poster__play-button"><circle cx="12" cy="11.998" r="11.25" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></circle><path d="M9 15.613a1.636 1.636 0 0 0 2.712 1.231L17.25 12l-5.538-4.847A1.635 1.635 0 0 0 9 8.384Z" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></button><div class="poster__caption-container"><p class="poster__duration">00:00:16</p><h2 class="poster__title">3D architecture of a Meissner corpuscle</h2><div class="LinesEllipsis text-overflow poster__caption"><div><p>A Meissner corpuscle is a group of cells that acts as a touch detector. Its 3D structure was revealed for the very first time using a cutting-edge microscopy technique called enhanced focused ion beam scanning electron microscopy (FIB-SEM).</p></div></div><div class="poster__credit">Video by Yury Nikolaev,</div></div></div></figure></figure></div></div></div></div><div class="article-content__container"><div class="article-content__item"><div class="article-content__text article-content__text--media-hidden"><p>How do we detect touch? Touch is as important as vision, hearing, or smell, but of all senses, its mechanism is the one we understand the least. In <a href="https://doi.org/10.1126/sciadv.adi4147">a study published September 13</a> in <em class="arx-italic-text">Science Advances</em>, a collaborative team of Yale researchers reveals both the 3D architecture and the mechanism of the groups of cells that act as touch detectors.</p> <p>Touch is known to be detected in the skin by specific groups of cells, or micro-organs, called mechanosensory corpuscles. “One of them, the Meissner corpuscle, helps us detect very fine textures and vibrations, which are very important for all aspects of everyday life,” said Slav Bagriantsev, PhD, associate professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine and co-senior author of the study together with Elena Gracheva, PhD, associate professor in the same department and of neuroscience.</p> <p>Meissner corpuscles contain two principal elements: lamellar cells and nerve endings. How corpuscles’ different components are organized relative to each other remained unknown. For an answer this question, the team used a cutting-edge electron microscopy technique at the <a href="https://medicine.yale.edu/fib-sem/">Yale FIB-SEM Core</a>. Further, Yury Nikolaev, PhD, postdoctoral fellow in Bagriantsev’s lab and co-first author of the study, used machine learning to obtain the first ever three-dimensional high-resolution structure of a Meissner corpuscle. The team revealed that, surprisingly, a single corpuscle is comprised of several lamellar cells and not one but two nerve endings.</p> <p><img src="" data-title="3D structure of a Meissner corpuscle" data-alt-text="3D structure of a Meissner corpuscle" data-caption="" data-credit="Yury Nikolaev, PhD" data-align="center" data-media-item-id="27718" data-file-id="337705"></p> <p>The researchers also sought to understand how the corpuscles’ different components communicate. “The overarching discovery is that lamellar cells can detect touch and then communicate that information to the nerve endings,” said Luke Ziolkowski, graduate student in the Interdepartmental Neuroscience Program and co-first author of the study.</p> <figure><blockquote><p>The textbooks would say that the neuronal ending is the touch detector, but what we show is that lamellar cells also contribute to touch sensation.</p><figcaption>Yury Nikolaev, PhD</figcaption></blockquote></figure> <p>The team hopes to take these findings further, wondering if the bicellular mechanism of the Meissner corpuscles could be generalized to other types of touch corpuscles.</p> <div> <p>“Potentially, this research will inform the development of tactile sensors for next generation of prosthetics,” said Bagriantsev.</p> </div> <p>The study is one of the first large multicellular structure reconstructions using enhanced focused ion beam scanning electron microscopy (FIB-SEM). The microscopy images were collected and reconstructed in collaboration with Song Pang, MS, director of Yale FIB-SEM Core, and C. Shan Xu, PhD, professor of cellular & molecular physiology. Slav Bagriantsev, PhD, associate professor of cellular & molecular physiology, and Elena Gracheva, PhD, associate professor of neuroscience and of cellular & molecular physiology (Program in <a href="https://medicine.yale.edu/cnnr/">Cellular Neuroscience, Neurodegeneration and Repair</a>, and <a href="https://medicine.yale.edu/kavli/">Kavli Institute for Neuroscience</a>), are senior authors of the study.</p></div></div><div class="article-content__item"><div class="article-tagged-profiles"><h2 class="article-tagged-profiles__title">Featured in this article</h2><div class="profile-list"><ul class="profile-list__item-container"><li class="profile-list__item profile-list__item--type--profile-list profile-list__item--size-mode--large profile-list__item--with-first-item-top-border"><div class="profile-detailed-info-list-item profile-detailed-info-list-item--link"><div class="profile-detailed-info-list-item__content-container"><a href="/profile/yury-nikolaev/" aria-label="Yury Nikolaev" class="profile-detailed-info-list-item__content"><div class="profile-detailed-info-list-item__thumbnail-wrapper"><span class="" style="display:inline-block"></span></div><div class="profile-detailed-info-list-item__info"><span class="profile-detailed-info-list-item__name">Yury Nikolaev, MSc, PhD</span><div class="LinesEllipsis text-overflow profile-detailed-info-list-item__title">Associate Research Scientist<wbr/></div></div></a></div></div></li><li class="profile-list__item profile-list__item--type--profile-list profile-list__item--size-mode--large profile-list__item--with-first-item-top-border"><div class="profile-detailed-info-list-item profile-detailed-info-list-item--link"><div class="profile-detailed-info-list-item__content-container"><a href="/profile/luke-ziolkowski/" aria-label="Luke Ziolkowski" class="profile-detailed-info-list-item__content"><div class="profile-detailed-info-list-item__thumbnail-wrapper"><span class="default-image 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120.5h289.2v3.2H1.6z" style="fill:currentCollor;stroke:currentCollor"></path></svg></span></div><div class="profile-detailed-info-list-item__info"><span class="profile-detailed-info-list-item__name">Luke Ziolkowski</span></div></a></div></div></li><li class="profile-list__item profile-list__item--type--profile-list profile-list__item--size-mode--large profile-list__item--with-first-item-top-border"><div class="profile-detailed-info-list-item profile-detailed-info-list-item--link"><div class="profile-detailed-info-list-item__content-container"><a href="/profile/song-pang/" aria-label="Song Pang" class="profile-detailed-info-list-item__content"><div class="profile-detailed-info-list-item__thumbnail-wrapper"><span class="" style="display:inline-block"></span></div><div class="profile-detailed-info-list-item__info"><span class="profile-detailed-info-list-item__name">Song Pang</span><div class="LinesEllipsis text-overflow profile-detailed-info-list-item__title">Director, FIB-SEM Collaboration Core<wbr/></div></div></a></div></div></li><li class="profile-list__item profile-list__item--type--profile-list profile-list__item--size-mode--large profile-list__item--with-first-item-top-border"><div class="profile-detailed-info-list-item profile-detailed-info-list-item--link"><div class="profile-detailed-info-list-item__content-container"><a href="/profile/c-shan-xu/" aria-label="C. Shan Xu" class="profile-detailed-info-list-item__content"><div class="profile-detailed-info-list-item__thumbnail-wrapper"><span class="" style="display:inline-block"></span></div><div class="profile-detailed-info-list-item__info"><span class="profile-detailed-info-list-item__name">C. Shan Xu, PhD</span><div class="LinesEllipsis text-overflow profile-detailed-info-list-item__title">Harvey and Kate Cushing Professor of Cellular & Molecular Physiology<wbr/></div></div></a></div></div></li><li class="profile-list__item profile-list__item--type--profile-list profile-list__item--size-mode--large profile-list__item--with-first-item-top-border"><div class="profile-detailed-info-list-item profile-detailed-info-list-item--link"><div class="profile-detailed-info-list-item__content-container"><a href="/profile/elena-gracheva/" aria-label="Elena Gracheva" class="profile-detailed-info-list-item__content"><div class="profile-detailed-info-list-item__thumbnail-wrapper"><span class="" style="display:inline-block"></span></div><div class="profile-detailed-info-list-item__info"><span class="profile-detailed-info-list-item__name">Elena Gracheva, PhD</span><div class="LinesEllipsis text-overflow profile-detailed-info-list-item__title">Professor of Cellular and Molecular Physiology and of Neuroscience<wbr/></div></div></a></div></div></li><li class="profile-list__item profile-list__item--type--profile-list profile-list__item--size-mode--large profile-list__item--with-first-item-top-border"><div class="profile-detailed-info-list-item profile-detailed-info-list-item--link"><div class="profile-detailed-info-list-item__content-container"><a href="/profile/sviatoslav-bagriantsev/" aria-label="Slav Bagriantsev" class="profile-detailed-info-list-item__content"><div class="profile-detailed-info-list-item__thumbnail-wrapper"><span class="" style="display:inline-block"></span></div><div class="profile-detailed-info-list-item__info"><span class="profile-detailed-info-list-item__name">Slav Bagriantsev, PhD</span><div class="LinesEllipsis text-overflow profile-detailed-info-list-item__title">Professor<wbr/></div></div></a></div></div></li></ul></div></div></div></div></article></section></div></div><div class="sidebar page__sidebar-container"><div 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Touch is as important as vision, hearing, or smell, but of all senses, its mechanism is the one we understand the least. In a study published September 13 in Science Advances, a collaborative team of Yale researchers reveals both the 3D architecture and the mechanism of the groups of cells that act as touch detectors. Touch is known to be detected in the skin by specific groups of cells, or micro-organs, called mechanosensory corpuscles. “One of them, the Meissner corpuscle, helps us detect very fine textures and vibrations, which are very important for all aspects of everyday life,” said Slav Bagriantsev, PhD, associate professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine and co-senior author of the study together with Elena Gracheva, PhD, associate professor in the same department and of neuroscience. Meissner corpuscles contain two principal elements: lamellar cells and nerve endings. How corpuscles’ different components are organized relative to each other remained unknown. For an answer this question, the team used a cutting-edge electron microscopy technique at the Yale FIB-SEM Core. Further, Yury Nikolaev, PhD, postdoctoral fellow in Bagriantsev’s lab and co-first author of the study, used machine learning to obtain the first ever three-dimensional high-resolution structure of a Meissner corpuscle. The team revealed that, surprisingly, a single corpuscle is comprised of several lamellar cells and not one but two nerve endings. The researchers also sought to understand how the corpuscles’ different components communicate. “The overarching discovery is that lamellar cells can detect touch and then communicate that information to the nerve endings,” said Luke Ziolkowski, graduate student in the Interdepartmental Neuroscience Program and co-first author of the study. The textbooks would say that the neuronal ending is the touch detector, but what we show is that lamellar cells also contribute to touch sensation.Yury Nikolaev, PhD The team hopes to take these findings further, wondering if the bicellular mechanism of the Meissner corpuscles could be generalized to other types of touch corpuscles. “Potentially, this research will inform the development of tactile sensors for next generation of prosthetics,” said Bagriantsev. The study is one of the first large multicellular structure reconstructions using enhanced focused ion beam scanning electron microscopy (FIB-SEM). The microscopy images were collected and reconstructed in collaboration with Song Pang, MS, director of Yale FIB-SEM Core, and C. Shan Xu, PhD, professor of cellular & molecular physiology. Slav Bagriantsev, PhD, associate professor of cellular & molecular physiology, and Elena Gracheva, PhD, associate professor of neuroscience and of cellular & molecular physiology (Program in Cellular Neuroscience, Neurodegeneration and Repair, and Kavli Institute for Neuroscience), are senior authors of the study.\",\"author\":[{\"@type\":\"Person\",\"name\":\"Pauline Charbogne\",\"@context\":\"http://schema.org\"}],\"keywords\":[],\"publisher\":{\"@type\":\"NewsMediaOrganization\",\"name\":\"Yale School of Medicine\",\"foundingDate\":\"1810-10-15\",\"duns\":\"003036709\",\"url\":\"https://medicine.yale.edu\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https://medicine.yale.edu/icons/ysm/largetile.png\",\"height\":310,\"width\":310,\"@context\":\"http://schema.org\"},\"sameAs\":[\"https://www.facebook.com/YaleSchoolOfMedicine\",\"https://twitter.com/YaleMed\",\"https://www.instagram.com/yaleschoolofmed/?hl=en\",\"https://www.linkedin.com/school/yale-university-school-of-medicine/\",\"https://www.youtube.com/user/YaleMedicine\",\"https://vimeo.com/user30675202\"],\"department\":\"Office of Communication\",\"parentOrganization\":{\"@type\":\"CollegeOrUniversity\",\"Name\":\"Yale University\",\"foundingDate\":\"1701\",\"duns\":\"043207562\",\"url\":\"https://www.yale.edu/\",\"address\":{\"@type\":\"PostalAddress\",\"addressCountry\":\"USA\",\"addressLocality\":\"New Haven\",\"addressRegion\":\"CT\",\"postalCode\":\"06520\",\"streetAddress\":\"333 Cedar Street\",\"@context\":\"http://schema.org\"},\"@context\":\"http://schema.org\"},\"@context\":\"http://schema.org\"},\"@context\":\"http://schema.org\"}"}],"cmsPageMetaData":{"id":20990,"lastPublishedDate":"2024-09-17T11:34:41.0410548Z","editPageUrl":"https://beatrix.yale.edu/cms/websites/101/pages/20990/content/edit"},"privacyCookiesUrl":"/ysm/privacy/#cookies","publicationUrl":"/ysm","topBanner":null,"mainComponents":[{"key":"NewsDetails","orderOnPage":1,"model":{"title":"Researchers Map the 3D Structure of Touch Receptors and Reveal New Mechanism of Touch Detection","subTitle":null,"summary":"Scientists reveal the 3D architecture and mechanism of mechanosensory corpuscles, a group of cells that act as a touch detector.","content":"<p>How do we detect touch? Touch is as important as vision, hearing, or smell, but of all senses, its mechanism is the one we understand the least. In <a href=\"https://doi.org/10.1126/sciadv.adi4147\">a study published September 13</a> in <em class=\"arx-italic-text\">Science Advances</em>, a collaborative team of Yale researchers reveals both the 3D architecture and the mechanism of the groups of cells that act as touch detectors.</p> <p>Touch is known to be detected in the skin by specific groups of cells, or micro-organs, called mechanosensory corpuscles. “One of them, the Meissner corpuscle, helps us detect very fine textures and vibrations, which are very important for all aspects of everyday life,” said Slav Bagriantsev, PhD, associate professor in the Department of Cellular &amp; Molecular Physiology at Yale School of Medicine and co-senior author of the study together with Elena Gracheva, PhD, associate professor in the same department and of neuroscience.</p> <p>Meissner corpuscles contain two principal elements: lamellar cells and nerve endings. How corpuscles’ different components are organized relative to each other remained unknown. For an answer this question, the team used a cutting-edge electron microscopy technique at the <a href=\"https://medicine.yale.edu/fib-sem/\">Yale FIB-SEM Core</a>. Further, Yury Nikolaev, PhD, postdoctoral fellow in Bagriantsev’s lab and co-first author of the study, used machine learning to obtain the first ever three-dimensional high-resolution structure of a Meissner corpuscle. The team revealed that, surprisingly, a single corpuscle is comprised of several lamellar cells and not one but two nerve endings.</p> <p><img src=\"https://res.cloudinary.com/ysm/image/upload/yms/prod/d6a89058-c8f8-414b-b34e-4da670d05a80\" data-title=\"3D structure of a Meissner corpuscle\" data-alt-text=\"3D structure of a Meissner corpuscle\" data-caption=\"\" data-credit=\"Yury Nikolaev, PhD\" data-align=\"center\" data-media-item-id=\"27718\" data-file-id=\"337705\"></p> <p>The researchers also sought to understand how the corpuscles’ different components communicate. “The overarching discovery is that lamellar cells can detect touch and then communicate that information to the nerve endings,” said Luke Ziolkowski, graduate student in the Interdepartmental Neuroscience Program and co-first author of the study.</p> <figure><blockquote><p>The textbooks would say that the neuronal ending is the touch detector, but what we show is that lamellar cells also contribute to touch sensation.</p><figcaption>Yury Nikolaev, PhD</figcaption></blockquote></figure> <p>The team hopes to take these findings further, wondering if the bicellular mechanism of the Meissner corpuscles could be generalized to other types of touch corpuscles.</p> <div> <p>“Potentially, this research will inform the development of tactile sensors for next generation of prosthetics,” said Bagriantsev.</p> </div> <p>The study is one of the first large multicellular structure reconstructions using enhanced focused ion beam scanning electron microscopy (FIB-SEM). The microscopy images were collected and reconstructed in collaboration with Song Pang, MS, director of Yale FIB-SEM Core, and C. Shan Xu, PhD, professor of cellular &amp; molecular physiology. Slav Bagriantsev, PhD, associate professor of cellular &amp; molecular physiology, and Elena Gracheva, PhD, associate professor of neuroscience and of cellular &amp; molecular physiology (Program in <a href=\"https://medicine.yale.edu/cnnr/\">Cellular Neuroscience, Neurodegeneration and Repair</a>, and <a href=\"https://medicine.yale.edu/kavli/\">Kavli Institute for Neuroscience</a>), are senior authors of the study.</p>","bylineDate":"2023-09-13T18:05:00Z","createdDate":"2023-09-13T00:00:00Z","submitter":"","sidebarTitle":null,"sidebarContent":null,"contact":null,"heroGallery":{"title":null,"items":[{"galleryItemType":"media","mediaId":0,"data":{"detailsPageUrl":"/ysm/media-player/meissnercorpuscle/","publishedDate":null,"adaptiveStreamingUrl":"https://beatrix.yale.edu//api/media/media/10702/urls/adaptive-streaming","progressiveDownloadUrl":"https://beatrix.yale.edu//api/media/media/10702/urls/progressive-download","mediaType":"video","duration":"00:00:16","transcriptUrl":null,"mediaItemType":"internal","id":10702,"title":"3D architecture of a Meissner corpuscle","description":"<p>A Meissner corpuscle is a group of cells that acts as a touch detector. 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Touch is as important as vision, hearing, or smell, but of all senses, its mechanism is the one we understand the least. In a study published September 13 in Science Advances, a collaborative team of Yale researchers reveals both the 3D architecture and the mechanism of the groups of cells that act as touch detectors. Touch is known to be detected in the skin by specific groups of cells, or micro-organs, called mechanosensory corpuscles. “One of them, the Meissner corpuscle, helps us detect very fine textures and vibrations, which are very important for all aspects of everyday life,” said Slav Bagriantsev, PhD, associate professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine and co-senior author of the study together with Elena Gracheva, PhD, associate professor in the same department and of neuroscience. Meissner corpuscles contain two principal elements: lamellar cells and nerve endings. How corpuscles’ different components are organized relative to each other remained unknown. For an answer this question, the team used a cutting-edge electron microscopy technique at the Yale FIB-SEM Core. Further, Yury Nikolaev, PhD, postdoctoral fellow in Bagriantsev’s lab and co-first author of the study, used machine learning to obtain the first ever three-dimensional high-resolution structure of a Meissner corpuscle. The team revealed that, surprisingly, a single corpuscle is comprised of several lamellar cells and not one but two nerve endings. The researchers also sought to understand how the corpuscles’ different components communicate. “The overarching discovery is that lamellar cells can detect touch and then communicate that information to the nerve endings,” said Luke Ziolkowski, graduate student in the Interdepartmental Neuroscience Program and co-first author of the study. The textbooks would say that the neuronal ending is the touch detector, but what we show is that lamellar cells also contribute to touch sensation.Yury Nikolaev, PhD The team hopes to take these findings further, wondering if the bicellular mechanism of the Meissner corpuscles could be generalized to other types of touch corpuscles. “Potentially, this research will inform the development of tactile sensors for next generation of prosthetics,” said Bagriantsev. The study is one of the first large multicellular structure reconstructions using enhanced focused ion beam scanning electron microscopy (FIB-SEM). The microscopy images were collected and reconstructed in collaboration with Song Pang, MS, director of Yale FIB-SEM Core, and C. Shan Xu, PhD, professor of cellular & molecular physiology. Slav Bagriantsev, PhD, associate professor of cellular & molecular physiology, and Elena Gracheva, PhD, associate professor of neuroscience and of cellular & molecular physiology (Program in Cellular Neuroscience, Neurodegeneration and Repair, and Kavli Institute for Neuroscience), are senior authors of the study.\",\"author\":[{\"@type\":\"Person\",\"name\":\"Pauline Charbogne\",\"@context\":\"http://schema.org\"}],\"keywords\":[],\"publisher\":{\"@type\":\"NewsMediaOrganization\",\"name\":\"Yale School of Medicine\",\"foundingDate\":\"1810-10-15\",\"duns\":\"003036709\",\"url\":\"https://medicine.yale.edu\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https://medicine.yale.edu/icons/ysm/largetile.png\",\"height\":310,\"width\":310,\"@context\":\"http://schema.org\"},\"sameAs\":[\"https://www.facebook.com/YaleSchoolOfMedicine\",\"https://twitter.com/YaleMed\",\"https://www.instagram.com/yaleschoolofmed/?hl=en\",\"https://www.linkedin.com/school/yale-university-school-of-medicine/\",\"https://www.youtube.com/user/YaleMedicine\",\"https://vimeo.com/user30675202\"],\"department\":\"Office of Communication\",\"parentOrganization\":{\"@type\":\"CollegeOrUniversity\",\"Name\":\"Yale University\",\"foundingDate\":\"1701\",\"duns\":\"043207562\",\"url\":\"https://www.yale.edu/\",\"address\":{\"@type\":\"PostalAddress\",\"addressCountry\":\"USA\",\"addressLocality\":\"New Haven\",\"addressRegion\":\"CT\",\"postalCode\":\"06520\",\"streetAddress\":\"333 Cedar Street\",\"@context\":\"http://schema.org\"},\"@context\":\"http://schema.org\"},\"@context\":\"http://schema.org\"},\"@context\":\"http://schema.org\"}"}],"cta":null,"relatedEvents":[]}}],"sidebarComponents":[{"key":"NewsDetailsSidebar","orderOnPage":2,"model":{"title":"Researchers Map the 3D Structure of Touch Receptors and Reveal New Mechanism of Touch Detection","subTitle":null,"summary":"Scientists reveal the 3D architecture and mechanism of mechanosensory corpuscles, a group of cells that act as a touch detector.","content":"<p>How do we detect touch? Touch is as important as vision, hearing, or smell, but of all senses, its mechanism is the one we understand the least. In <a href=\"https://doi.org/10.1126/sciadv.adi4147\">a study published September 13</a> in <em class=\"arx-italic-text\">Science Advances</em>, a collaborative team of Yale researchers reveals both the 3D architecture and the mechanism of the groups of cells that act as touch detectors.</p> <p>Touch is known to be detected in the skin by specific groups of cells, or micro-organs, called mechanosensory corpuscles. “One of them, the Meissner corpuscle, helps us detect very fine textures and vibrations, which are very important for all aspects of everyday life,” said Slav Bagriantsev, PhD, associate professor in the Department of Cellular &amp; Molecular Physiology at Yale School of Medicine and co-senior author of the study together with Elena Gracheva, PhD, associate professor in the same department and of neuroscience.</p> <p>Meissner corpuscles contain two principal elements: lamellar cells and nerve endings. How corpuscles’ different components are organized relative to each other remained unknown. For an answer this question, the team used a cutting-edge electron microscopy technique at the <a href=\"https://medicine.yale.edu/fib-sem/\">Yale FIB-SEM Core</a>. Further, Yury Nikolaev, PhD, postdoctoral fellow in Bagriantsev’s lab and co-first author of the study, used machine learning to obtain the first ever three-dimensional high-resolution structure of a Meissner corpuscle. The team revealed that, surprisingly, a single corpuscle is comprised of several lamellar cells and not one but two nerve endings.</p> <p><img src=\"https://res.cloudinary.com/ysm/image/upload/yms/prod/d6a89058-c8f8-414b-b34e-4da670d05a80\" data-title=\"3D structure of a Meissner corpuscle\" data-alt-text=\"3D structure of a Meissner corpuscle\" data-caption=\"\" data-credit=\"Yury Nikolaev, PhD\" data-align=\"center\" data-media-item-id=\"27718\" data-file-id=\"337705\"></p> <p>The researchers also sought to understand how the corpuscles’ different components communicate. “The overarching discovery is that lamellar cells can detect touch and then communicate that information to the nerve endings,” said Luke Ziolkowski, graduate student in the Interdepartmental Neuroscience Program and co-first author of the study.</p> <figure><blockquote><p>The textbooks would say that the neuronal ending is the touch detector, but what we show is that lamellar cells also contribute to touch sensation.</p><figcaption>Yury Nikolaev, PhD</figcaption></blockquote></figure> <p>The team hopes to take these findings further, wondering if the bicellular mechanism of the Meissner corpuscles could be generalized to other types of touch corpuscles.</p> <div> <p>“Potentially, this research will inform the development of tactile sensors for next generation of prosthetics,” said Bagriantsev.</p> </div> <p>The study is one of the first large multicellular structure reconstructions using enhanced focused ion beam scanning electron microscopy (FIB-SEM). The microscopy images were collected and reconstructed in collaboration with Song Pang, MS, director of Yale FIB-SEM Core, and C. Shan Xu, PhD, professor of cellular &amp; molecular physiology. Slav Bagriantsev, PhD, associate professor of cellular &amp; molecular physiology, and Elena Gracheva, PhD, associate professor of neuroscience and of cellular &amp; molecular physiology (Program in <a href=\"https://medicine.yale.edu/cnnr/\">Cellular Neuroscience, Neurodegeneration and Repair</a>, and <a href=\"https://medicine.yale.edu/kavli/\">Kavli Institute for Neuroscience</a>), are senior authors of the study.</p>","bylineDate":"2023-09-13T18:05:00Z","createdDate":"2023-09-13T00:00:00Z","submitter":"","sidebarTitle":null,"sidebarContent":null,"contact":null,"heroGallery":{"title":null,"items":[{"galleryItemType":"media","mediaId":0,"data":{"detailsPageUrl":"/ysm/media-player/meissnercorpuscle/","publishedDate":null,"adaptiveStreamingUrl":"https://beatrix.yale.edu//api/media/media/10702/urls/adaptive-streaming","progressiveDownloadUrl":"https://beatrix.yale.edu//api/media/media/10702/urls/progressive-download","mediaType":"video","duration":"00:00:16","transcriptUrl":null,"mediaItemType":"internal","id":10702,"title":"3D architecture of a Meissner corpuscle","description":"<p>A Meissner corpuscle is a group of cells that acts as a touch detector. 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Touch is as important as vision, hearing, or smell, but of all senses, its mechanism is the one we understand the least. In a study published September 13 in Science Advances, a collaborative team of Yale researchers reveals both the 3D architecture and the mechanism of the groups of cells that act as touch detectors. Touch is known to be detected in the skin by specific groups of cells, or micro-organs, called mechanosensory corpuscles. “One of them, the Meissner corpuscle, helps us detect very fine textures and vibrations, which are very important for all aspects of everyday life,” said Slav Bagriantsev, PhD, associate professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine and co-senior author of the study together with Elena Gracheva, PhD, associate professor in the same department and of neuroscience. Meissner corpuscles contain two principal elements: lamellar cells and nerve endings. How corpuscles’ different components are organized relative to each other remained unknown. For an answer this question, the team used a cutting-edge electron microscopy technique at the Yale FIB-SEM Core. Further, Yury Nikolaev, PhD, postdoctoral fellow in Bagriantsev’s lab and co-first author of the study, used machine learning to obtain the first ever three-dimensional high-resolution structure of a Meissner corpuscle. The team revealed that, surprisingly, a single corpuscle is comprised of several lamellar cells and not one but two nerve endings. The researchers also sought to understand how the corpuscles’ different components communicate. “The overarching discovery is that lamellar cells can detect touch and then communicate that information to the nerve endings,” said Luke Ziolkowski, graduate student in the Interdepartmental Neuroscience Program and co-first author of the study. The textbooks would say that the neuronal ending is the touch detector, but what we show is that lamellar cells also contribute to touch sensation.Yury Nikolaev, PhD The team hopes to take these findings further, wondering if the bicellular mechanism of the Meissner corpuscles could be generalized to other types of touch corpuscles. “Potentially, this research will inform the development of tactile sensors for next generation of prosthetics,” said Bagriantsev. The study is one of the first large multicellular structure reconstructions using enhanced focused ion beam scanning electron microscopy (FIB-SEM). The microscopy images were collected and reconstructed in collaboration with Song Pang, MS, director of Yale FIB-SEM Core, and C. Shan Xu, PhD, professor of cellular & molecular physiology. Slav Bagriantsev, PhD, associate professor of cellular & molecular physiology, and Elena Gracheva, PhD, associate professor of neuroscience and of cellular & molecular physiology (Program in Cellular Neuroscience, Neurodegeneration and Repair, and Kavli Institute for Neuroscience), are senior authors of the study.\",\"author\":[{\"@type\":\"Person\",\"name\":\"Pauline Charbogne\",\"@context\":\"http://schema.org\"}],\"keywords\":[],\"publisher\":{\"@type\":\"NewsMediaOrganization\",\"name\":\"Yale School of 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Researchers Map the 3D Structure of Touch Receptors and Reveal New Mechanism of Touch Detection < Yale School of Medicine