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<!doctype html> <html lang="de"> <head> <title>Impact of SARS-CoV-2 Spikes on Safety of Spike-Based COVID-1 | 108040</title> <meta name="keywords" content="Karla Johanna Lehmann, "/> <meta name="description" content="The purpose of this review is to update the key findings from the scientific literature that provide explanations for many of the reported and analyzed a..108040"/> <meta name="citation_publisher" content="Longdom Publishing SL" /> <meta name="citation_journal_title" content="Immunomforschung"> <meta name="citation_title" content="Impact of SARS-CoV-2 Spikes on Safety of Spike-Based COVID-19 Vaccinations"> <meta name="citation_author" content="Karla Johanna Lehmann" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="20"> <meta name="citation_issue" content="2"> <meta name="citation_abstract" content="The purpose of this review is to update the key findings from the scientific literature that provide explanations for many of the reported and analyzed adverse effects associated with the spike-based COVID-19 vaccination. An overwhelming body of evidence supports the main mode of action of spike-based COVID-19 vaccines, namely the downregulation of ACE2 by spikes. Direct spike effects, synergisms and RAAS-independent responses complement and multiply the already deleterious effects on tolerability. It has been repeatedly confirmed that the SARS-CoV spike protein alone is not only able to downregulate ACE2, but also to induce cell fusion, activation of TLR4, of co-receptors and gastrointestinal responses. The systemic and long-lasting detection of spikes after vaccination disproves the claimed regionally limited and short-lasting spike production and efficacy. The exceptionally broad spectrum, frequency and severity of the reported ADRs associated with spike-based COVID-19 vaccination exceed the known level of conventional vaccinations. According to ADR analyses, the spike-based vaccines possess an unacceptable class-specific, unique ADR/side effect profile. From a pharmacological point of view, spikes are highly active substances, but not harmless antigens. For this reason, they are not appropriate for preventive immunization to avoid comparatively harmless infections. 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nav-link" href="https://german.longdom.org/business-and-management-journals.html" title="Hier klicken">Wirtschaft & Management</a><br> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9"> <h2 class="heading-1">Abstrakt</h2> <h3 class="">Impact of SARS-CoV-2 Spikes on Safety of Spike-Based COVID-19 Vaccinations</h3> <p> <i class="fas fa-user"></i> Karla Johanna Lehmann </p> <p>The purpose of this review is to update the key findings from the scientific literature that provide explanations for many of the reported and analyzed adverse effects associated with the spike-based COVID-19 vaccination. </p> <p> An overwhelming body of evidence supports the main mode of action of spike-based COVID-19 vaccines, namely the downregulation of ACE2 by spikes. Direct spike effects, synergisms and RAAS-independent responses complement and multiply the already deleterious effects on tolerability. </p> <p> It has been repeatedly confirmed that the SARS-CoV spike protein alone is not only able to downregulate ACE2, but also to induce cell fusion, activation of TLR4, of co-receptors and gastrointestinal responses. The systemic and long-lasting detection of spikes after vaccination disproves the claimed regionally limited and short-lasting spike production and efficacy. </p> <p> The exceptionally broad spectrum, frequency and severity of the reported ADRs associated with spike-based COVID-19 vaccination exceed the known level of conventional vaccinations. </p> <p>According to ADR analyses, the spike-based vaccines possess an unacceptable class-specific, unique ADR/side effect profile. </p> <p> From a pharmacological point of view, spikes are highly active substances, but not harmless antigens. For this reason, they are not appropriate for preventive immunization to avoid comparatively harmless infections. </p> <div class="alert alert-info text-left"><b>Haftungsausschluss:</b> Diese Zusammenfassung wurde mithilfe von Tools der k眉nstlichen Intelligenz 眉bersetzt und wurde noch nicht 眉berpr眉ft oder verifiziert.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Teile diesen Artikel</a> <a title="Hier klicken" target="_blank" href="https://www.facebook.com/sharer.php?u=https://german.longdom.org/abstract/impact-of-sarscov2-spikes-on-safety-of-spikebased-covid19-vaccinations-108040.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Hier klicken" target="_blank" href="https://twitter.com/share?url=https://german.longdom.org/abstract/impact-of-sarscov2-spikes-on-safety-of-spikebased-covid19-vaccinations-108040.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Hier klicken" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://german.longdom.org/abstract/impact-of-sarscov2-spikes-on-safety-of-spikebased-covid19-vaccinations-108040.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Hier klicken" target="_blank" href="https://plus.google.com/share?url=https://german.longdom.org/abstract/impact-of-sarscov2-spikes-on-safety-of-spikebased-covid19-vaccinations-108040.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Inhaltslinks</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://german.longdom.org/privacy-policy.html" title="Hier klicken">Datenschutzrichtlinie</a></li> <li><a class="" href="https://german.longdom.org/terms-conditions.html" title="Hier klicken">Allgemeine Gesch盲ftsbedingungen</a></li> <li><a class="" href="https://german.longdom.org/authors-reviewers-editors.html" title="Hier klicken">Autoren, Gutachter & Herausgeber</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Kontaktieren Sie Longdom</h4> <p><strong>Longdom Group SA</strong><br /> Avenue Roger Vandendriessche,<br /> 18, 1150 Br眉ssel, Belgien<br /> Telefon: +442038085340<br /> <strong>E-Mail:</strong> <a class="white" href="mailto:info@longdom.org" title="Hier klicken">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Verbinden</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Hier klicken" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Hier klicken" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="Hier klicken" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="Hier klicken" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Urheberrechte 漏 © 2024 <a href="https://german.longdom.org/" title="Hier klicken" class="white">Longdom Publishing SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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