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type="hidden" name="start" form="facetForm" value="0"/></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/00s8h914"><div class="c-clientmarkup">Single cell transcriptomics of ABEDINIUM reveals a new early-branching dinoflagellate lineage</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ACooney%2C%20Elizabeth%20C">Cooney, Elizabeth C</a>; </li><li><a href="/search/?q=author%3AOkamoto%2C%20Noriko">Okamoto, Noriko</a>; </li><li><a href="/search/?q=author%3ACho%2C%20Anna">Cho, Anna</a>; </li><li><a href="/search/?q=author%3AHehenberger%2C%20Elisabeth">Hehenberger, Elisabeth</a>; </li><li><a href="/search/?q=author%3ARichards%2C%20Thomas%20A">Richards, Thomas A</a>; </li><li><a href="/search/?q=author%3ASantoro%2C%20Alyson%20E">Santoro, Alyson E</a>; </li><li><a href="/search/?q=author%3AWorden%2C%20Alexandra%20Z">Worden, Alexandra Z</a>; </li><li><a href="/search/?q=author%3ALeander%2C%20Brian%20S">Leander, Brian S</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AKeeling%2C%20Patrick%20J">Keeling, Patrick J</a> </li><li class="c-authorlist__begin"><span class="c-authorlist__heading">Editor(s):</span> <a href="/search/?q=author%3AGeoff%2C%20McFadden">Geoff, McFadden</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsb_postprints">UC Santa Barbara Previously Published Works</a> (2020)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Dinoflagellates possess many cellular characteristics with unresolved evolutionary histories. These include nuclei with greatly expanded genomes and chromatin packaged using histone-like proteins and dinoflagellate-viral nucleoproteins instead of histones, highly reduced mitochondrial genomes with extensive RNA editing, a mix of photosynthetic and cryptic secondary plastids, and tertiary plastids. Resolving the evolutionary origin of these traits requires understanding their ancestral states and early intermediates. Several early-branching dinoflagellate lineages are good candidates for such reconstruction, however these cells tend to be delicate and environmentally sparse, complicating such analyses. Here, we employ transcriptome sequencing from manually isolated and microscopically documented cells to resolve the placement of two cells of one such genus, Abedinium, collected by remotely operated vehicle in deep waters off the coast of Monterey Bay, CA. One cell corresponds to the only described species, Abedinium dasypus, whereas the second cell is distinct and formally described as Abedinium folium, sp. nov. Abedinium has classically been assigned to the early-branching dinoflagellate subgroup Noctilucales, which is weakly supported by phylogenetic analyses of small subunit ribosomal RNA, the single characterized gene from any member of the order. However, an analysis based on 221 proteins from the transcriptome places Abedinium as a distinct lineage, separate from and basal to Noctilucales and the rest of the core dinoflagellates. The transcriptome also contains evidence of a cryptic plastid functioning in the biosynthesis of isoprenoids, iron-sulfur clusters, and heme, a mitochondrial genome with all three expected protein-coding genes (cob, cox1, and cox3), and the presence of some but not all dinoflagellate-specific chromatin packaging proteins.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/00s8h914"><img src="/cms-assets/e200eceb167557e8cb0722a25ed9c1bc56efbcbfcbb816db380d4567c7999be6" alt="Cover page: Single cell transcriptomics of ABEDINIUM reveals a new early-branching dinoflagellate lineage"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/1n63w1qs"><div class="c-clientmarkup">Biosynthesis of chlorophyll c in a dinoflagellate and heterologous production in planta</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AJinkerson%2C%20Robert%20E">Jinkerson, Robert E</a>; </li><li><a href="/search/?q=author%3APoveda-Huertes%2C%20Daniel">Poveda-Huertes, Daniel</a>; </li><li><a href="/search/?q=author%3ACooney%2C%20Elizabeth%20C">Cooney, Elizabeth C</a>; </li><li><a href="/search/?q=author%3ACho%2C%20Anna">Cho, Anna</a>; </li><li><a href="/search/?q=author%3AOchoa-Fernandez%2C%20Rocio">Ochoa-Fernandez, Rocio</a>; </li><li><a href="/search/?q=author%3AKeeling%2C%20Patrick%20J">Keeling, Patrick J</a>; </li><li><a href="/search/?q=author%3AXiang%2C%20Tingting">Xiang, Tingting</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AAndersen-Ranberg%2C%20Johan">Andersen-Ranberg, Johan</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucr_postprints">UC Riverside Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Chlorophyll c is a key photosynthetic pigment that has been used historically to classify eukaryotic algae. Despite its importance in global photosynthetic productivity, the pathway for its biosynthesis has remained elusive. Here we define the CHLOROPHYLL C SYNTHASE (CHLCS) discovered through investigation of a dinoflagellate mutant deficient in chlorophyll c. CHLCSs are proteins with chlorophyll a/b binding and 2-oxoglutarate-Fe(II) dioxygenase (2OGD) domains found in peridinin-containing dinoflagellates; other chlorophyll c-containing algae utilize enzymes with only the 2OGD domain or an unknown synthase to produce chlorophyll c. 2OGD-containing synthases across dinoflagellate, diatom, cryptophyte, and haptophyte lineages form a monophyletic group, 8 members of which were also shown to produce chlorophyll c. Chlorophyll c<sub>1</sub> to c<sub>2</sub> ratios in marine algae are dictated in part by chlorophyll c synthases. CHLCS heterologously expressed in planta results in the accumulation of chlorophyll c<sub>1</sub> and c<sub>2</sub>, demonstrating a path to augment plant pigment composition with algal counterparts.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a href="https://creativecommons.org/licenses/by-nc/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-nc-small.svg" alt="Creative Commons 'BY-NC' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/9kt9c853"><div class="c-clientmarkup">E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ALee%2C%20Geonhui">Lee, Geonhui</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Claudia">Wong, Claudia</a>; </li><li><a href="/search/?q=author%3ACho%2C%20Anna">Cho, Anna</a>; </li><li><a href="/search/?q=author%3AWest%2C%20Junior">West, Junior</a>; </li><li><a href="/search/?q=author%3ACrawford%2C%20Ashleigh">Crawford, Ashleigh</a>; </li><li><a href="/search/?q=author%3ARusso%2C%20Gabriella">Russo, Gabriella</a>; </li><li><a href="/search/?q=author%3ASi%2C%20Bishwa">Si, Bishwa</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Jungwoo">Kim, Jungwoo</a>; </li><li><a href="/search/?q=author%3AHoffner%2C%20Lauren">Hoffner, Lauren</a>; </li><li><a href="/search/?q=author%3AJang%2C%20Cholsoon">Jang, Cholsoon</a>; </li><li><a href="/search/?q=author%3AJung%2C%20Moonjung">Jung, Moonjung</a>; </li><li><a href="/search/?q=author%3ALeone%2C%20Robert">Leone, Robert</a>; </li><li><a href="/search/?q=author%3AKonstantopoulos%2C%20Konstantinos">Konstantopoulos, Konstantinos</a>; </li><li><a href="/search/?q=author%3AEwald%2C%20Andrew">Ewald, Andrew</a>; </li><li><a href="/search/?q=author%3AWirtz%2C%20Denis">Wirtz, Denis</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AJeong%2C%20Sangmoo">Jeong, Sangmoo</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/uci_postprints">UC Irvine Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">The loss of E-cadherin, an epithelial cell adhesion molecule, has been implicated in metastasis by mediating the epithelial-mesenchymal transition, which promotes invasion and migration of cancer cells. However, recent studies have demonstrated that E-cadherin supports the survival and proliferation of metastatic cancer cells. Here, we identified a metabolic role for E-cadherin in breast cancer by upregulating the de novo serine synthesis pathway (SSP). The upregulated SSP provided metabolic precursors for biosynthesis and resistance to oxidative stress, enabling E-cadherin+ breast cancer cells to achieve faster tumor growth and enhanced metastases. Inhibition of phosphoglycerate dehydrogenase, a rate-limiting enzyme in the SSP, significantly and specifically hampered proliferation of E-cadherin+ breast cancer cells and rendered them vulnerable to oxidative stress, inhibiting their metastatic potential. These findings reveal that E-cadherin reprograms cellular metabolism, promoting tumor growth and metastasis of breast cancers. Significance: E-Cadherin promotes the progression and metastasis of breast cancer by upregulating the de novo serine synthesis pathway, offering promising targets for inhibiting tumor growth and metastasis in E-cadherin-expressing tumors.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/9kt9c853"><img src="/cms-assets/19b603d8f4dbcd7c63dca9384933c12e724b312feb82f98e4f274829cd127a22" alt="Cover page: E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer."/></a></div></section></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright 漏 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-3c8ebc2ec05dcc3202fd.js"></script> </body> </html>