CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Search results for: AChE and BChE inhibition</title> <meta name="description" content="Search results for: AChE and BChE inhibition"> <meta name="keywords" content="AChE and BChE inhibition"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="AChE and BChE inhibition" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="AChE and BChE inhibition"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1051</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: AChE and BChE inhibition</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1051</span> Synthesis and Biological Evaluation of Some Benzoxazole Derivatives as Inhibitors of Acetylcholinesterase / Butyrylcholinesterase and Tyrosinase</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ozlem%20Temiz-Arpaci">Ozlem Temiz-Arpaci</a>, <a href="https://publications.waset.org/abstracts/search?q=Meryem%20Tasci"> Meryem Tasci</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatma%20Sezer%20Senol"> Fatma Sezer Senol</a>, <a href="https://publications.waset.org/abstracts/search?q=%C4%B0lkay%20Erdogan%20Orhan"> İlkay Erdogan Orhan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Alzheimer’s disease (AD), a neurodegenerative disorder characterized by a progressive deterioration of memory and cognition, occurs more frequently in elderly people. Current treatment approaches in this disease with the major therapeutic strategy are based on the AChE and BChE inhibition. On the other hand, tyrosinase inhibition has become a target for the treatment of Parkinson’s disease (PD) since this enzyme may play a role in neuromelanin formation in the human brain and could be critical in the formation of dopamine neurotoxicity associated with neurodegeneration linked to PD. Also benzoxazoles are structural isosteres of natural nucleotides that can interact with biopolymers so that benzoxazoles showed a lot of different biological activities. In this study, a series of 2,5-disubstituted-benzoxazole derivatives were synthesized and were evaluated as possible inhibitors of acetylcholinesterase (AChE) / butyrylcholinesterase (BChE) and tyrosinase. The results demonstrated that the compounds exhibited a weak spectrum of AChE / BChE inhibitory activity ranging between 3.92% - 54.32% except compound 8 which showed no activity against AChE and compound 4 which showed no activity against BChE at the specified molar concentrations. Also, the compounds indicated lower than tyrosinase inhibitory activity of ranging between 8.14% - 22.90% to that of reference (kojic acid). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition" title="AChE and BChE inhibition">AChE and BChE inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%E2%80%99s%20disease" title=" Alzheimer’s disease"> Alzheimer’s disease</a>, <a href="https://publications.waset.org/abstracts/search?q=benzoxazoles" title=" benzoxazoles"> benzoxazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=tyrosinase%20inhibition" title=" tyrosinase inhibition"> tyrosinase inhibition</a> </p> <a href="https://publications.waset.org/abstracts/66790/synthesis-and-biological-evaluation-of-some-benzoxazole-derivatives-as-inhibitors-of-acetylcholinesterase-butyrylcholinesterase-and-tyrosinase" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66790.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">341</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1050</span> Cholinesterase Inhibitory Indole Alkaloids from the Bark of Rauvolfia reflexa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mehran%20Fadaeinasab">Mehran Fadaeinasab</a>, <a href="https://publications.waset.org/abstracts/search?q=Alireza%20Basiri"> Alireza Basiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Yalda%20Kia"> Yalda Kia</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamed%20Karimian"> Hamed Karimian</a>, <a href="https://publications.waset.org/abstracts/search?q=Hapipah%20Mohd%20Ali"> Hapipah Mohd Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Vikneswaran%20Murugaiyah"> Vikneswaran Murugaiyah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Two new, rauvolfine C and 3- methyl-10,11-dimethoxyl-6- methoxycarbonyl- β- carboline, along with five known indole alkaloids, macusine B, vinorine, undulifoline, isoresrpiline and rescinnamine were isolated from the bark of Rauvolfia reflexa. All the compounds showed good to moderate cholinesterase inhibitory activity with IC50 values in the range of 8.06 to 73.23 πM, except rauvolfine C that was inactive against acetylcholinesterase (AChE). Rescinnamine, a dual inhibitor was found to be the most potent inhibitor among the isolated alkaloids against both AChE and butyrylcholinesterase (BChE). Molecular docking revealed that rescinnamine interacted differently on AChE and BChE, by means of hydrophobic interactions and hydrogen bonding. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rauvolfia%20reflexa" title="Rauvolfia reflexa">Rauvolfia reflexa</a>, <a href="https://publications.waset.org/abstracts/search?q=indole%20alkaloids" title=" indole alkaloids"> indole alkaloids</a>, <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title=" acetylcholinesterase"> acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=butyrylcholinesterase" title=" butyrylcholinesterase"> butyrylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a> </p> <a href="https://publications.waset.org/abstracts/30034/cholinesterase-inhibitory-indole-alkaloids-from-the-bark-of-rauvolfia-reflexa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30034.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">592</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1049</span> Biochemical Efficacy, Molecular Docking and Inhibitory Effect of 2,3-Dimethylmaleic Anhydride on Acetylcholinesterases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kabrambam%20D.%20Singh">Kabrambam D. Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Dinabandhu%20Sahoo"> Dinabandhu Sahoo</a>, <a href="https://publications.waset.org/abstracts/search?q=Yallappa%20Rajashekar"> Yallappa Rajashekar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Evolution has caused many insects to develop resistance to several synthetic insecticides. This problem along with the persisting concern regarding the health and environmental safety issues of the existing synthetic insecticides has urged the scientific fraternity to look for a new plant-based natural insecticide with inherent eco-friendly nature. Colocasia esculenta var. esculenta (L.) Schott (Araceae family) is widely grown throughout the South- East Asian Countries for its edible corms and leaves. Various physico-chemical and spectroscopic techniques (IR, 1H NMR, 13C NMR and Mass) were used for the isolation and characterization of isolated bioactive molecule named 2, 3-dimethylmaleic anhydride (3, 4-dimethyl-2, 5-furandione). This compound was found to be highly toxic, even at low concentration, against several storage grain pests when used as biofumigant. Experimental studies on the mode of action of 2, 3-dimethylmaleic anhydride revealed that the biofumigant act as inhibitor of acetylcholinesterase enzyme in cockroach and stored grain insects. The knockdown activity of bioactive compound is concurrent with in vivo inhibition of AChE; at KD99 dosage of bioactive molecule showed more than 90% inhibition of AChE activity in test insects. The molecule proved to affect the antioxidant enzyme system; superoxide dismutase (SOD), and catalase (CAT) and also found to decrease reduced glutathione (GSH) level in the treated insects. The above results indicate involvement of inhibition of AChE activity and oxidative imbalance as the potential mode of action of 2, 3-dimethylmaleic anhydride. In addition, the study reveals computational docking programs elaborate the possible interaction of 2, 3-dimethylmaleic anhydride with enzyme acetylcholinesterase (AChE) of Periplaneta americana. Finally, the results represent that toxicity of 2, 3-dimethylmaleic anhydride might be associated with inhibition of AChE activity and oxidative imbalance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=2" title="2">2</a>, <a href="https://publications.waset.org/abstracts/search?q=3-dimethylmaleic%20anhydride" title="3-dimethylmaleic anhydride">3-dimethylmaleic anhydride</a>, <a href="https://publications.waset.org/abstracts/search?q=Colocasia%20esculenta%20var.%20esculenta%20%28L.%29%20Schott" title=" Colocasia esculenta var. esculenta (L.) Schott"> Colocasia esculenta var. esculenta (L.) Schott</a>, <a href="https://publications.waset.org/abstracts/search?q=Biofumigant" title=" Biofumigant"> Biofumigant</a>, <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title=" acetylcholinesterase"> acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20enzyme" title=" antioxidant enzyme"> antioxidant enzyme</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a> </p> <a href="https://publications.waset.org/abstracts/77828/biochemical-efficacy-molecular-docking-and-inhibitory-effect-of-23-dimethylmaleic-anhydride-on-acetylcholinesterases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77828.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1048</span> Biomonitoring of Marine Environment by Using a Bioindicator Donax trunculus (Mollusca, Bivalvia) from the Gulf of Annaba (Algeria): Biomarkers Responses</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Karima%20Sifi">Karima Sifi</a>, <a href="https://publications.waset.org/abstracts/search?q=Noureddine%20Soltani"> Noureddine Soltani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Annaba gulf is the most important touristic and economic area located on the east coast of Algeria. However, these fishery resources are threatened by the pollution due to the progress of economic activity. As part of a biomonitoring program on the quality of waters of the Gulf of Annaba, the specific activity of two biomarkers, acetylcholinesterase (AChE) and glutathion S-transferase (GST) has been measured in edible bivalve Donax trunculus. The samples have been collected during the year 2013 in two sites: El Battah, distant from polluted sources, and Sidi Salem, located near the harbor and different industrial waste. The results showed a significant inhibition of AChE activity and a significant increase in the activity of the GST in samples collected from Sidi Salem as compared to El Battah. The inhibition of the AChE and the increase of the GST in Sidi Salem are in relation with the level of exposition of this site to the pollution. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Donax%20trunculus" title="Donax trunculus">Donax trunculus</a>, <a href="https://publications.waset.org/abstracts/search?q=annaba%20gulf" title=" annaba gulf"> annaba gulf</a>, <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title=" acetylcholinesterase"> acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=glutathion%20s-transferase" title=" glutathion s-transferase"> glutathion s-transferase</a>, <a href="https://publications.waset.org/abstracts/search?q=biomonitoring" title=" biomonitoring"> biomonitoring</a>, <a href="https://publications.waset.org/abstracts/search?q=pollution" title=" pollution"> pollution</a> </p> <a href="https://publications.waset.org/abstracts/31216/biomonitoring-of-marine-environment-by-using-a-bioindicator-donax-trunculus-mollusca-bivalvia-from-the-gulf-of-annaba-algeria-biomarkers-responses" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31216.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">387</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1047</span> Biological Activities of Gentiana brachyphylla Vill. Herba from Turkey</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hulya%20Tuba%20Kiyan">Hulya Tuba Kiyan</a>, <a href="https://publications.waset.org/abstracts/search?q=Nilgun%20Ozturk"> Nilgun Ozturk</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gentiana, a member of Gentianaceae, is represented by approximately 400 species in the world and 12 species in Turkey. Flavonoids, iridoids, triterpenoids and also xanthones are the major compounds of this genus, have been previously reported to have antiinflammatory, antimicrobial, antioxidant, hepatoprotective, hypotensive, hypoglycaemic, DNA repair and immunomodulatory properties. The methanolic extract of the aerial parts of Gentiana brachyphylla Vill. from Turkey was evaluated for its biological activities and its total phenolic content in the present study. According to the antioxidant activity results, G. brachyphylla methanolic extract showed very strong anti-DNA damage antioxidant activity with an inhibition of 81.82%. It showed weak ferric-reducing power with a EC50 value of 0.65 when compared to BHT (EC50 = 0.2). Also, at 0.5 mg/ml concentration, the methanolic extract inhibited ABTS radical cation activity with an inhibition of 20.13% when compared to Trolox (79.01%). Chelating ability of G. brachyphylla was 44.71% whereas EDTA showed 78.87% chelating activity at 0.2 mg/ml. Also G. brachyphylla showed weak 27.21% AChE, 20.23% BChE, strong 67.86% MAO-A and moderate 50.06% MAO-B, weak 19.14% COX-1, 29.11% COX-2 inhibitory activities at 0.25 mg/ml. The total phenolic content of G. brachyphylla was 156.23 ± 2.73 mg gallic acid equivalent/100 g extract. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title="antioxidant activity">antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=cholinesterase%20inhibitory%20activity" title=" cholinesterase inhibitory activity"> cholinesterase inhibitory activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Gentiana%20brachyphylla%20Vill." title=" Gentiana brachyphylla Vill."> Gentiana brachyphylla Vill.</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20phenolic%20content" title=" total phenolic content"> total phenolic content</a> </p> <a href="https://publications.waset.org/abstracts/81660/biological-activities-of-gentiana-brachyphylla-vill-herba-from-turkey" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81660.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">201</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1046</span> Kinetics and Toxicological Effects of Kickxia elatine Extract-Based Silver Nanoparticles on Rat Brain Acetylcholinesterase</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Noor%20Ul%20Huda">Noor Ul Huda</a>, <a href="https://publications.waset.org/abstracts/search?q=Mushtaq%20Ahmed"> Mushtaq Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Nadia%20Mushtaq"> Nadia Mushtaq</a>, <a href="https://publications.waset.org/abstracts/search?q=Naila%20Sher"> Naila Sher</a>, <a href="https://publications.waset.org/abstracts/search?q=Rahmat%20Ali%20Khan"> Rahmat Ali Khan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: The green synthesis of AgNPs has been favored over chemical synthesis due to their distinctive properties such as high dispersion, surface-to-volume ratio, low toxicity, and easy preparation. In the present work, the biosynthesis of AgNPs (KE-AgNPs) was carried out in one step by using the traditionally used plant Kickxia elatine (KE) extract and then investigated its enzyme inhibiting activity against rat’s brain acetylcholinesterase (AChE) in vitro. Methods: KE-AgNPs were synthesized from 1mM AgNO₃ using KE extract and characterized by UV–spectroscopy, SEM, EDX, XRD, and FTIR analysis. Rat’s brain acetylcholinesterase (AChE) inhibition activity was evaluated by the standard protocol. Results: UV–spectrum at 416 nm confirmed the formation of KE-AgNPs. X-ray diffraction (XRD) pattern presented 2θ values corresponding to the crystalline nature of KE-AgNPs with an average size of 42.47nm. The scanning electron microscope (SEM) analysis confirmed the presence of spherical-shaped and huge density KE-AgNPs with a size of 50nm. Fourier transform infrared spectroscopy (FT-IR) suggested that the functional groups present in KE extract and on the surface of KE-AgNPs are responsible for the stability of biosynthesized NPs. Energy dispersive X-ray (EDX) displayed an intense sharp peak at 3.2 keV, presenting that Ag was the chief element with 61.67%. Both KE extract and KE-AgNPs showed good and potent anti-AChE activity, with higher inhibition potential at a concentration of 175 µg/ml. Statistical analysis showed that both KEE and AgNPs exhibited non-competitive type inhibition against AChE, i.e., Vmax decreased (34.17-68.64% and 22.29- 62.10%) in the concentration-dependent mode for KEE and KE-AgNPs respectively and while Km values remained constant. Conclusions: KEE and KE-AgNPs can be considered an inhibitor of rats’ brain AChE, and the synthesis of KE-AgNPs-based drugs can be used as a cheaper and alternative option against diseases such as Alzheimer’s disease. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kickxia%20elatine" title="Kickxia elatine">Kickxia elatine</a>, <a href="https://publications.waset.org/abstracts/search?q=AgNPs" title=" AgNPs"> AgNPs</a>, <a href="https://publications.waset.org/abstracts/search?q=brain%20homogenate" title=" brain homogenate"> brain homogenate</a>, <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title=" acetylcholinesterase"> acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetics" title=" kinetics"> kinetics</a> </p> <a href="https://publications.waset.org/abstracts/154992/kinetics-and-toxicological-effects-of-kickxia-elatine-extract-based-silver-nanoparticles-on-rat-brain-acetylcholinesterase" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154992.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">121</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1045</span> Arisarum Vulgare: Bridging Tradition and Science through Phytochemical Characterization and Exploring Therapeutic Potential via in vitro and in vivo Biological Activities</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Boudjelal%20Amel">Boudjelal Amel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Arisarum vulgare, a member of the Araceae family, is an herbaceous perennial widely distributed in the Mediterranean region. A. vulgare is recognized for its medicinal properties and holds significant traditional importance in Algeria for the treatment of various human ailments, including pain, infections, inflammation, digestive disorders, skin problems, eczema, cancer, wounds, burns and gynecological diseases. Despite its extensive traditional use, scientific exploration of A. vulgare remains limited. The study aims to investigate for the first time the therapeutic potential of A. vulgare ethanolic extract obtained by ultrasound-assisted extraction. The chemical composition of the extract was determined by LC-MS/MS analysis. For in vitro phytopharmacological evaluation, several assays, including DPPH, ABTS, FRAP and reducing power, were employed to evaluate the antioxidant activity. The antibacterial activity was assessed againt Escherichia coli, Salmonella typhimurium, Staphylococus aureus, Enterococcus feacium by disk diffusion and microdilution methods. The possible inhibitory activity of ethanolic extract was analyzed against the cholinesterases enzymes (AChE and BChE). The DNA protection activity of A. vulgare ethanolic extract was estimated using the agarose gel electrophoresis method. The capacities of the extract to protect plasmid DNA (pBR322) from the oxidizing effects of H2O2 and UV treatment were evaluated by their DNA-breaking forms. The in vivo wound healing potential of a traditional ointment containing 5% of A. vulgare ethanolic extract was also investigated. The LC-MS/MS profiling of the extract revealed the presence of various bioactive compounds, including naringenin, chlorogenic, vanillic, cafeic, coumaric acids, trans-cinnamic and trans ferrulic acids. The plant extract presented considerable antioxidant potential, being the most active for Reducing power (0,07326±0.001 mg/ml) and DPPH (0.14±0.004 mg/ml). The extract showed the highest inhibition zone diameter against Enterococcus feacium (36±0.1 mm). The ethanolic extract of A. vulgare suppressed the growth of Staphylococus aureus, Escherichia coli and Salmonella typhimurium according to the MIC values. The extract of the plant significantly inhibited both AChE and BChE enzymes. DNA protection activity of the A. vulgare extract was determined as 90.41% for form I and 51.92% for form II. The in vivo experiments showed that 5% ethanolic extract ointment accelerated the wound healing process. The topical application of the traditional formulation enhanced wound closure (95,36±0,6 %) and improved histological parameters in the treated group compared to the control groups. The promising biological properties of Arisarum vulgare revealed that the plant could be appraised as a potential origin of bioactive molecules having multifunctional medicinal uses. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=arisarum%20vulgare" title="arisarum vulgare">arisarum vulgare</a>, <a href="https://publications.waset.org/abstracts/search?q=LC-MS%2FMS" title=" LC-MS/MS"> LC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title=" antimicrobial activity"> antimicrobial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=cholinesterases%20enzymes%20inhibition" title=" cholinesterases enzymes inhibition"> cholinesterases enzymes inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=dna-damage%20activity" title=" dna-damage activity"> dna-damage activity</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vivo%20wound%20healing" title=" in vivo wound healing"> in vivo wound healing</a> </p> <a href="https://publications.waset.org/abstracts/183263/arisarum-vulgare-bridging-tradition-and-science-through-phytochemical-characterization-and-exploring-therapeutic-potential-via-in-vitro-and-in-vivo-biological-activities" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/183263.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">69</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1044</span> Molecular Interaction of Acetylcholinesterase with Flavonoids Involved in Neurodegenerative Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=W.%20Soufi">W. Soufi</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Boukli%20Hacene"> F. Boukli Hacene</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Ghalem"> S. Ghalem</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Alzheimer's disease (AD) is a neurodegenerative disease that leads to a progressive and permanent deterioration of nerve cells. This disease is progressively accompanied by an intellectual deterioration leading to psychological manifestations and behavioral disorders that lead to a loss of autonomy. It is the most frequent of degenerative dementia. Alzheimer's disease (AD), which affects a growing number of people, has become a major public health problem in a few years. In the context of the study of the mechanisms governing the evolution of AD disease, we have found that natural flavonoids are good acetylcholinesterase inhibitors that reduce the rate of ßA secretion in neurons. This work is to study the inhibition of acetylcholinesterase (AChE) which is an enzyme involved in Alzheimer's disease, by methods of molecular modeling. These results will probably help in the development of an effective therapeutic tool in the fight against the development of Alzheimer's disease. Our goal of the research is to study the inhibition of acetylcholinesterase (AChE) by molecular modeling methods. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%27s%20disease" title="Alzheimer's disease">Alzheimer's disease</a>, <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title=" acetylcholinesterase"> acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20modeling" title=" molecular modeling"> molecular modeling</a> </p> <a href="https://publications.waset.org/abstracts/156249/molecular-interaction-of-acetylcholinesterase-with-flavonoids-involved-in-neurodegenerative-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156249.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">105</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1043</span> A Preliminary in vitro Investigation of the Acetylcholinesterase and α-Amylase Inhibition Potential of Pomegranate Peel Extracts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zoi%20Konsoula">Zoi Konsoula</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The increasing prevalence of Alzheimer’s disease (AD) and diabetes mellitus (DM) constitutes them major global health problems. Recently, the inhibition of key enzyme activity is considered a potential treatment of both diseases. Specifically, inhibition of acetylcholinesterase (AChE), the key enzyme involved in the breakdown of the neurotransmitter acetylcholine, is a promising approach for the treatment of AD, while inhibition of α-amylase retards the hydrolysis of carbohydrates and, thus, reduces hyperglycemia. Unfortunately, commercially available AChE and α-amylase inhibitors are reported to possess side effects. Consequently, there is a need to develop safe and effective treatments for both diseases. In the present study, pomegranate peel (PP) was extracted using various solvents of increasing polarity, while two extraction methods were employed, the conventional maceration and the ultrasound assisted extraction (UAE). The concentration of bioactive phytoconstituents, such as total phenolics (TPC) and total flavonoids (TFC) in the prepared extracts was evaluated by the Folin-Ciocalteu and the aluminum-flavonoid complex method, respectively. Furthermore, the anti-neurodegenerative and anti-hyperglycemic activity of all extracts was determined using AChE and α-amylase inhibitory activity assays, respectively. The inhibitory activity of the extracts against AChE and α-amylase was characterized by estimating their IC₅₀ value using a dose-response curve, while galanthamine and acarbose were used as positive controls, respectively. Finally, the kinetics of AChE and α-amylase in the presence of the most inhibitory potent extracts was determined by the Lineweaver-Burk plot. The methanolic extract prepared using the UAE contained the highest amount of phytoconstituents, followed by the respective ethanolic extract. All extracts inhibited acetylcholinesterase in a dose-dependent manner, while the increased anticholinesterase activity of the methanolic (IC₅₀ = 32 μg/mL) and ethanolic (IC₅₀ = 42 μg/mL) extract was positively correlated with their TPC content. Furthermore, the activity of the aforementioned extracts was comparable to galanthamine. Similar results were obtained in the case of α-amylase, however, all extracts showed lower inhibitory effect on the carbohydrate hydrolyzing enzyme than on AChE, since the IC₅₀ value ranged from 84 to 100 μg/mL. Also, the α-amylase inhibitory effect of the extracts was lower than acarbose. Finally, the methanolic and ethanolic extracts prepared by UAE inhibited both enzymes in a mixed (competitive/noncompetitive) manner since the Kₘ value of both enzymes increased in the presence of extracts, while the Vmax value decreased. The results of the present study indicate that PP may be a useful source of active compounds for the management of AD and DM. Moreover, taking into consideration that PP is an agro-industrial waste product, its valorization could not only result in economic efficiency but also reduce the environmental pollution. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title="acetylcholinesterase">acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%E2%80%99s%20disease" title=" Alzheimer’s disease"> Alzheimer’s disease</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B1-amylase" title=" α-amylase"> α-amylase</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes%20mellitus" title=" diabetes mellitus"> diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=pomegranate" title=" pomegranate"> pomegranate</a> </p> <a href="https://publications.waset.org/abstracts/92004/a-preliminary-in-vitro-investigation-of-the-acetylcholinesterase-and-a-amylase-inhibition-potential-of-pomegranate-peel-extracts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92004.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1042</span> Alterations in Esterases and Phosphatases of Three Economically Important Stored Grain Insect Pests Exposed to Botanical Extracts, Nicotiana tabacum and Eucalyptus globulus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kazam%20Ali">Kazam Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Sagheer"> Muhammad Sagheer</a>, <a href="https://publications.waset.org/abstracts/search?q=Mansoor-Ul-%20Hasan"> Mansoor-Ul- Hasan</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Rashid"> Abdul Rashid</a>, <a href="https://publications.waset.org/abstracts/search?q=Chaudhary%20Muhammad%20Shahid%20Hanif"> Chaudhary Muhammad Shahid Hanif</a>, <a href="https://publications.waset.org/abstracts/search?q=Fawad%20Zafar%20Ahmad%20Khan"> Fawad Zafar Ahmad Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Hafiz%20Muhammad%20Aatif"> Hafiz Muhammad Aatif</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural extracts of two medicinal plants Nicotiana tabacum and Eucalyptus globulus were tested for their toxic and enzyme inhibition effects against three insects species of stored grains Tribolium castaneum, Trogoderma granarium and Sitophilus granarius. Responses of insects varied with exposure periods and dilution levels of acetone extracts of plants. Both plant extracts were lethal to insects but the crude leaf extract of N. tabacum evidenced strong toxic action against three tested insect species. Maximum mortality 36.30% in S. granarius, 25.96% in T. castaneum, and 21.88% in T. granarium were found at 20% dilution level, after 10 days exposure to botanical extract of N. tabacum. The impact of N. tabacum and E. globulus on the activity of esterases; acetylcholinesterase (AChE), α-carboxylesterase (α-CE), β-carboxylesterase (β-CE) and phosphatses; acid phosphatase (AcP), alkaline phosphatase (AlP) of three stored grain insect species were also studied in the survivors of toxicity assay. Whole body homogenates of insects were used for enzyme determination and consumption of high dose rate N. tabacum extract containing diet resulted in maximum 55.33% inhibition of AChE and 26.17% AlP inhibition in T. castaneum, while 44.17% of α-CE and 31.67% inhibition of β-CE activity were noted in S. granarius. Maximum inhibition 23.44% of AcP activity was found in T. granarium exposed to diet treated with the extract of E. globulus. The findings indicate that acetone extracts of N. tabacum and E. globulus are naturally occurring pesticide and facts of the enzyme inhibition relations specify that their effect changes with the insect species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=natural%20extract" title="natural extract">natural extract</a>, <a href="https://publications.waset.org/abstracts/search?q=medicinal%20plant" title=" medicinal plant"> medicinal plant</a>, <a href="https://publications.waset.org/abstracts/search?q=toxic%20effects" title=" toxic effects"> toxic effects</a>, <a href="https://publications.waset.org/abstracts/search?q=enzyme%20inhibition" title=" enzyme inhibition"> enzyme inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=acetone%20extract" title=" acetone extract"> acetone extract</a> </p> <a href="https://publications.waset.org/abstracts/78395/alterations-in-esterases-and-phosphatases-of-three-economically-important-stored-grain-insect-pests-exposed-to-botanical-extracts-nicotiana-tabacum-and-eucalyptus-globulus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78395.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">258</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1041</span> Structure-Guided Optimization of Sulphonamide as Gamma–Secretase Inhibitors for the Treatment of Alzheimer’s Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vaishali%20Patil">Vaishali Patil</a>, <a href="https://publications.waset.org/abstracts/search?q=Neeraj%20Masand"> Neeraj Masand</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In older people, Alzheimer’s disease (AD) is turning out to be a lethal disease. According to the amyloid hypothesis, aggregation of the amyloid β–protein (Aβ), particularly its 42-residue variant (Aβ42), plays direct role in the pathogenesis of AD. Aβ is generated through sequential cleavage of amyloid precursor protein (APP) by β–secretase (BACE) and γ–secretase (GS). Thus in the treatment of AD, γ-secretase modulators (GSMs) are potential disease-modifying as they selectively lower pathogenic Aβ42 levels by shifting the enzyme cleavage sites without inhibiting γ–secretase activity. This possibly avoids known adverse effects observed with complete inhibition of the enzyme complex. Virtual screening, via drug-like ADMET filter, QSAR and molecular docking analyses, has been utilized to identify novel γ–secretase modulators with sulphonamide nucleus. Based on QSAR analyses and docking score, some novel analogs have been synthesized. The results obtained by in silico studies have been validated by performing in vivo analysis. In the first step, behavioral assessment has been carried out using Scopolamine induced amnesia methodology. Later the same series has been evaluated for neuroprotective potential against the oxidative stress induced by Scopolamine. Biochemical estimation was performed to evaluate the changes in biochemical markers of Alzheimer’s disease such as lipid peroxidation (LPO), Glutathione reductase (GSH), and Catalase. The Scopolamine induced amnesia model has shown increased Acetylcholinesterase (AChE) levels and the inhibitory effect of test compounds in the brain AChE levels have been evaluated. In all the studies Donapezil (Dose: 50µg/kg) has been used as reference drug. The reduced AChE activity is shown by compounds 3f, 3c, and 3e. In the later stage, the most potent compounds have been evaluated for Aβ42 inhibitory profile. It can be hypothesized that this series of alkyl-aryl sulphonamides exhibit anti-AD activity by inhibition of Acetylcholinesterase (AChE) enzyme as well as inhibition of plaque formation on prolong dosage along with neuroprotection from oxidative stress. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gamma-secretase%20inhibitors" title="gamma-secretase inhibitors">gamma-secretase inhibitors</a>, <a href="https://publications.waset.org/abstracts/search?q=Alzzheimer%27s%20disease" title=" Alzzheimer's disease"> Alzzheimer's disease</a>, <a href="https://publications.waset.org/abstracts/search?q=sulphonamides" title=" sulphonamides"> sulphonamides</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a> </p> <a href="https://publications.waset.org/abstracts/77906/structure-guided-optimization-of-sulphonamide-as-gamma-secretase-inhibitors-for-the-treatment-of-alzheimers-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77906.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">254</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1040</span> Synthesis and Anticholinesterase Activity of Carvacrol Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatih%20Sonmez">Fatih Sonmez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Alzheimer’s disease (AD) is a progressive neurodegenerative disease and it is the most common form of dementia that affects aged people. Acetylcholinesterase is a hydrolase involved in the termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter ACh in the central and peripheral nervous system. Carvacrol (5-iso-propyl-2-methyl-phenol) is a main bioactive monoterpene isolated from many medicinal herbs, such as Thymus vulgaris, Monarda punctate and Origanum vulgare spp. It is known that carvacrol has been widely used as an active anti-inflammatory ingredient, which can inhibit the isoproterenol induced inflammation in myocardial infarcted rats. In this paper, a series of 12 carvacrol substituted carbamate derivatives (2a-l) was synthesized and their inhibitory activities on AChE and BuChE were evaluated. Among them, 2d exhibited the strongest inhibition against AChE with an IC50 value of 2.22 µM, which was 130-fold more than that of carvacrol (IC50 = 288.26 µM). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Acetylcholinesterase" title="Acetylcholinesterase">Acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=Butyrylcholinesterase" title=" Butyrylcholinesterase"> Butyrylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=Carbamate" title=" Carbamate"> Carbamate</a>, <a href="https://publications.waset.org/abstracts/search?q=Carvacrol" title=" Carvacrol"> Carvacrol</a> </p> <a href="https://publications.waset.org/abstracts/61252/synthesis-and-anticholinesterase-activity-of-carvacrol-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61252.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">352</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1039</span> Design, Synthesis and Evaluation of 4-(Phenylsulfonamido)Benzamide Derivatives as Selective Butyrylcholinesterase Inhibitors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sushil%20Kumar%20Singh">Sushil Kumar Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashok%20Kumar"> Ashok Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Ankit%20%20Ganeshpurkar"> Ankit Ganeshpurkar</a>, <a href="https://publications.waset.org/abstracts/search?q=Ravi%20Singh"> Ravi Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Devendra%20Kumar"> Devendra Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In spectrum of neurodegenerative diseases, Alzheimer’s disease (AD) is characterized by the presence of amyloid β plaques and neurofibrillary tangles in the brain. It results in cognitive and memory impairment due to loss of cholinergic neurons, which is considered to be one of the contributing factors. Donepezil, an acetylcholinesterase (AChE) inhibitor which also inhibits butyrylcholinesterase (BuChE) and improves the memory and brain’s cognitive functions, is the most successful and prescribed drug to treat the symptoms of AD. The present work is based on designing of the selective BuChE inhibitors using computational techniques. In this work, machine learning models were trained using classification algorithms followed by screening of diverse chemical library of compounds. The various molecular modelling and simulation techniques were used to obtain the virtual hits. The amide derivatives of 4-(phenylsulfonamido) benzoic acid were synthesized and characterized using 1H & 13C NMR, FTIR and mass spectrometry. The enzyme inhibition assays were performed on equine plasma BuChE and electric eel’s AChE by method developed by Ellman et al. Compounds 31, 34, 37, 42, 49, 52 and 54 were found to be active against equine BuChE. N-(2-chlorophenyl)-4-(phenylsulfonamido)benzamide and N-(2-bromophenyl)-4-(phenylsulfonamido)benzamide (compounds 34 and 37) displayed IC50 of 61.32 ± 7.21 and 42.64 ± 2.17 nM against equine plasma BuChE. Ortho-substituted derivatives were more active against BuChE. Further, the ortho-halogen and ortho-alkyl substituted derivatives were found to be most active among all with minimal AChE inhibition. The compounds were selective toward BuChE. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%20disease" title="Alzheimer disease">Alzheimer disease</a>, <a href="https://publications.waset.org/abstracts/search?q=butyrylcholinesterase" title=" butyrylcholinesterase"> butyrylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a>, <a href="https://publications.waset.org/abstracts/search?q=sulfonamides" title=" sulfonamides "> sulfonamides </a> </p> <a href="https://publications.waset.org/abstracts/122292/design-synthesis-and-evaluation-of-4-phenylsulfonamidobenzamide-derivatives-as-selective-butyrylcholinesterase-inhibitors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/122292.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">139</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1038</span> In vivo Inhibition and Restoration of Acetyl Cholinesterase Activities in Induced Clarias Gariepinus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=T.%20O.%20Ikpesu">T. O. Ikpesu</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Tongo"> I. Tongo</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Ariyo"> A. Ariyo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study was conducted to assess the effects of an organophosphate pesticide glyphosate formulation on neurological enzymes in the brain, liver and serum of juvenile Clarias gariepinus, and also to examine the antidotal prospect of Garcinia kola seeds extract. The fish divided into five groups were exposed to different treatments of glyphosate formulation and Garcinia kola seeds extract. Acetyl cholinesterase activities in the brain, liver and serum of the fish were estimated in the experimental and control fishes on day -7, 14, 21 and of 28 by spectrophotometrical methods. The enzyme was significantly (p < 0.05) inhibited in glyphosate formulation test. The inhibition percentages of AChE ranged for the brain, liver and serum between 40.7–59.4%, 50-57% and 27.5–51.3%, respectively. The aberrated parameters were recovered in G. kola seeds extract treated aquaria, and was dose and time dependent. The present study demonstrated that in vivo glyphosate formulation exposure caused AChE inhibition in the brain, liver and the serum. The brain tissue, however, might be suggested as a good indicator tissue for aquatic pollutants exposure in the fish and G. kola seeds extract has shown to be a good remedy for neurology restoration in a noxious circumstance. The findings has shown that xenobiotics could be eliminated from aquatic organisms, especially fish, and could be put into practice in areas at risk of pollutants. This approach can reduce the risks of biomagnification of poison in sea food. Hence, formulation of this plant extracts into capsule should be encouraged and supported. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glyphosate" title="glyphosate">glyphosate</a>, <a href="https://publications.waset.org/abstracts/search?q=Clarias%20gariepinus" title=" Clarias gariepinus"> Clarias gariepinus</a>, <a href="https://publications.waset.org/abstracts/search?q=brain" title=" brain"> brain</a>, <a href="https://publications.waset.org/abstracts/search?q=Garcinia%20kola" title=" Garcinia kola"> Garcinia kola</a>, <a href="https://publications.waset.org/abstracts/search?q=acetyl%20cholinesterase" title=" acetyl cholinesterase"> acetyl cholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=enzymes" title=" enzymes "> enzymes </a> </p> <a href="https://publications.waset.org/abstracts/9259/in-vivo-inhibition-and-restoration-of-acetyl-cholinesterase-activities-in-induced-clarias-gariepinus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9259.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">391</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1037</span> Chronic Toxicity of Halofenozide on a Larvivorous Fish, Gambusia affinis: Acetylcholinesterase, Glutathione S-transferase Activities and Glutathione</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chouahda%20Salima">Chouahda Salima</a>, <a href="https://publications.waset.org/abstracts/search?q=Soltani%20Noureddine"> Soltani Noureddine</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study is a part of biological control against mosquitoes. It aims to assess the impact of a selective insect growth regulator: halofenozide in mosquitofish: Gambusia affinis. Acetylcholinesterase (AChE), glutathione S-transferase (GST) and glutathione (GSH) used in assessing of environmental stress were measured in juveniles and adults males and females. The response of these biomarkers reveals an inhibition of AChE specific activity, an induction of GST activity, and decrease of GSH rates in juveniles in the end of experiment and during chronic treatment adult males and females. The effect of these biomarkers is more pronounced in females compared to males and juveniles. These different biomarkers have a similar profile for the duration of exposure. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomarkers" title="biomarkers">biomarkers</a>, <a href="https://publications.waset.org/abstracts/search?q=chronic%20toxicity" title=" chronic toxicity"> chronic toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=insecticide" title=" insecticide"> insecticide</a>, <a href="https://publications.waset.org/abstracts/search?q=halofenozide" title=" halofenozide"> halofenozide</a>, <a href="https://publications.waset.org/abstracts/search?q=Gambusia%20affinis" title=" Gambusia affinis"> Gambusia affinis</a>, <a href="https://publications.waset.org/abstracts/search?q=pollution" title=" pollution"> pollution</a> </p> <a href="https://publications.waset.org/abstracts/32658/chronic-toxicity-of-halofenozide-on-a-larvivorous-fish-gambusia-affinis-acetylcholinesterase-glutathione-s-transferase-activities-and-glutathione" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32658.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">341</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1036</span> Multi-Walled Carbon Nanotubes Doped Poly (3,4 Ethylenedioxythiophene) Composites Based Electrochemical Nano-Biosensor for Organophosphate Detection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Navpreet%20Kaur">Navpreet Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Himkusha%20Thakur"> Himkusha Thakur</a>, <a href="https://publications.waset.org/abstracts/search?q=Nirmal%20Prabhakar"> Nirmal Prabhakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the most publicized and controversial issue in crop production is the use of agrichemicals- also known as pesticides. This is evident in many reports that Organophosphate (OP) insecticides, among the broad range of pesticides are mainly involved in acute and chronic poisoning cases. Therefore, detection of OPs is very necessary for health protection, food and environmental safety. In our study, a nanocomposite of poly (3,4 ethylenedioxythiophene) (PEDOT) and multi-walled carbon nanotubes (MWCNTs) has been deposited electrochemically onto the surface of fluorine doped tin oxide sheets (FTO) for the analysis of malathion OP. The -COOH functionalization of MWCNTs has been done for the covalent binding with amino groups of AChE enzyme. The use of PEDOT-MWCNT films exhibited an excellent conductivity, enables fast transfer kinetics and provided a favourable biocompatible microenvironment for AChE, for the significant malathion OP detection. The prepared PEDOT-MWCNT/FTO and AChE/PEDOT-MWCNT/FTO nano-biosensors were characterized by Fourier transform infrared spectrometry (FTIR), Field emission-scanning electron microscopy (FE-SEM) and electrochemical studies. Electrochemical studies were done using Cyclic Voltammetry (CV) or Differential Pulse Voltammetry (DPV) and Electrochemical Impedance Spectroscopy (EIS). Various optimization studies were done for different parameters including pH (7.5), AChE concentration (50 mU), substrate concentration (0.3 mM) and inhibition time (10 min). The detection limit for malathion OP was calculated to be 1 fM within the linear range 1 fM to 1 µM. The activity of inhibited AChE enzyme was restored to 98% of its original value by 2-pyridine aldoxime methiodide (2-PAM) (5 mM) treatment for 11 min. The oxime 2-PAM is able to remove malathion from the active site of AChE by means of trans-esterification reaction. The storage stability and reusability of the prepared nano-biosensor is observed to be 30 days and seven times, respectively. The application of the developed nano-biosensor has also been evaluated for spiked lettuce sample. Recoveries of malathion from the spiked lettuce sample ranged between 96-98%. The low detection limit obtained by the developed nano-biosensor made them reliable, sensitive and a low cost process. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PEDOT-MWCNT" title="PEDOT-MWCNT">PEDOT-MWCNT</a>, <a href="https://publications.waset.org/abstracts/search?q=malathion" title=" malathion"> malathion</a>, <a href="https://publications.waset.org/abstracts/search?q=organophosphates" title=" organophosphates"> organophosphates</a>, <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title=" acetylcholinesterase"> acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-biosensor" title=" nano-biosensor"> nano-biosensor</a>, <a href="https://publications.waset.org/abstracts/search?q=oxime%20%282-PAM%29" title=" oxime (2-PAM)"> oxime (2-PAM)</a> </p> <a href="https://publications.waset.org/abstracts/42617/multi-walled-carbon-nanotubes-doped-poly-34-ethylenedioxythiophene-composites-based-electrochemical-nano-biosensor-for-organophosphate-detection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42617.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">435</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1035</span> Gambusia an Excellent Indicator of Metals Stress </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=W.%20Khati">W. Khati</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Guasmi"> Y. Guasmi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The activity of acetylcholinesterase (AChE) was studied in freshwater fish exposed to two heavy metals lead and cadmium. Measurements were made after short exposures (4 and 7 days) at concentrations of 1, 5, and 7μg/L cadmium and 1.25, 2.25, and 5 mg/L of lead. Cadmium induced no significant increases in activity of AChE in the gills for the lowest dose. Except significant inhibition on 7 days. In muscle of Gambusia, under stress of metallic lead, the activity increases compared to the control are noted at 4 days of treatment and inhibitions to 7 days of exposure. The analysis of variance (time, treatment) indicates only a very significant time effect (p<0.05), and as for cadmium, a significant body effect (p<0.01) is recorded. This small fish sedentary, colonizing particularly quiet environments, polluted, can only be the ideal bioindicator of contamination and bioaccumulation of metals. The presence of lead and cadmium in the bodies of fish is a risk factor not only for the lives of these aquatic species, but also for the man who is the top predator at the end of the food chain. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomarkers" title="biomarkers">biomarkers</a>, <a href="https://publications.waset.org/abstracts/search?q=bioindicator" title=" bioindicator"> bioindicator</a>, <a href="https://publications.waset.org/abstracts/search?q=environmenlal%20health" title=" environmenlal health"> environmenlal health</a>, <a href="https://publications.waset.org/abstracts/search?q=metals" title=" metals"> metals</a> </p> <a href="https://publications.waset.org/abstracts/18566/gambusia-an-excellent-indicator-of-metals-stress" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18566.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">498</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1034</span> Biosensors for Parathion Based on Au-Pd Nanoparticles Modified Electrodes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tian-Fang%20Kang">Tian-Fang Kang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chao-Nan%20Ge"> Chao-Nan Ge</a>, <a href="https://publications.waset.org/abstracts/search?q=Rui%20Li"> Rui Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An electrochemical biosensor for the determination of organophosphorus pesticides was developed based on electrochemical co-deposition of Au and Pd nanoparticles on glassy carbon electrode (GCE). Energy disperse spectroscopy (EDS) analysis was used for characterization of the surface structure. Scanning electron micrograph (SEM) demonstrates that the films are uniform and the nanoclusters are homogeneously distributed on the GCE surface. Acetylcholinesterase (AChE) was immobilized on the Au and Pd nanoparticle modified electrode (Au-Pd/GCE) by cross-linking with glutaraldehyde. The electrochemical behavior of thiocholine at the biosensor (AChE/Au-Pd/GCE) was studied. The biosensors exhibited substantial electrocatalytic effect on the oxidation of thiocholine. The peak current of linear scan voltammetry (LSV) of thiocholine at the biosensor is proportional to the concentration of acetylthiocholine chloride (ATCl) over the range of 2.5 × 10-6 to 2.5 × 10-4 M in 0.1 M phosphate buffer solution (pH 7.0). The percent inhibition of acetylcholinesterase was proportional to the logarithm of parathion concentration in the range of 4.0 × 10-9 to 1.0 × 10-6 M. The detection limit of parathion was 2.6 × 10-9 M. The proposed method exhibited high sensitivity and good reproducibility. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title="acetylcholinesterase">acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=Au-Pd%20nanoparticles" title=" Au-Pd nanoparticles"> Au-Pd nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=electrochemical%20biosensors" title=" electrochemical biosensors"> electrochemical biosensors</a>, <a href="https://publications.waset.org/abstracts/search?q=parathion" title=" parathion "> parathion </a> </p> <a href="https://publications.waset.org/abstracts/17756/biosensors-for-parathion-based-on-au-pd-nanoparticles-modified-electrodes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17756.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">407</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1033</span> An Electrochemical Enzymatic Biosensor Based on Multi-Walled Carbon Nanotubes and Poly (3,4 Ethylenedioxythiophene) Nanocomposites for Organophosphate Detection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Navpreet%20Kaur">Navpreet Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Himkusha%20Thakur"> Himkusha Thakur</a>, <a href="https://publications.waset.org/abstracts/search?q=Nirmal%20Prabhakar"> Nirmal Prabhakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The most controversial issue in crop production is the use of Organophosphate insecticides. This is evident in many reports that Organophosphate (OP) insecticides, among the broad range of pesticides are mainly involved in acute and chronic poisoning cases. OPs detection is of crucial importance for health protection, food and environmental safety. In our study, a nanocomposite of poly (3,4 ethylenedioxythiophene) (PEDOT) and multi-walled carbon nanotubes (MWCNTs) has been deposited electrochemically onto the surface of fluorine doped tin oxide sheets (FTO) for the analysis of malathion OP. The -COOH functionalization of MWCNTs has been done for the covalent binding with amino groups of AChE enzyme. The use of PEDOT-MWCNT films exhibited an excellent conductivity, enables fast transfer kinetics and provided a favourable biocompatible microenvironment for AChE, for the significant malathion OP detection. The prepared biosensors were characterized by Fourier transform infrared spectrometry (FTIR), Field emission-scanning electron microscopy (FE-SEM) and electrochemical studies. Various optimization studies were done for different parameters including pH (7.5), AChE concentration (50 mU), substrate concentration (0.3 mM) and inhibition time (10 min). Substrate kinetics has been performed and studied for the determination of Michaelis Menten constant. The detection limit for malathion OP was calculated to be 1 fM within the linear range 1 fM to 1 µM. The activity of inhibited AChE enzyme was restored to 98% of its original value by 2-pyridine aldoxime methiodide (2-PAM) (5 mM) treatment for 11 min. The oxime 2-PAM is able to remove malathion from the active site of AChE by means of trans-esterification reaction. The storage stability and reusability of the prepared biosensor is observed to be 30 days and seven times, respectively. The application of the developed biosensor has also been evaluated for spiked lettuce sample. Recoveries of malathion from the spiked lettuce sample ranged between 96-98%. The low detection limit obtained by the developed biosensor made them reliable, sensitive and a low cost process. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PEDOT-MWCNT" title="PEDOT-MWCNT">PEDOT-MWCNT</a>, <a href="https://publications.waset.org/abstracts/search?q=malathion" title=" malathion"> malathion</a>, <a href="https://publications.waset.org/abstracts/search?q=organophosphates" title=" organophosphates"> organophosphates</a>, <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title=" acetylcholinesterase"> acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=biosensor" title=" biosensor"> biosensor</a>, <a href="https://publications.waset.org/abstracts/search?q=oxime%20%282-PAM%29" title=" oxime (2-PAM)"> oxime (2-PAM)</a> </p> <a href="https://publications.waset.org/abstracts/42622/an-electrochemical-enzymatic-biosensor-based-on-multi-walled-carbon-nanotubes-and-poly-34-ethylenedioxythiophene-nanocomposites-for-organophosphate-detection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42622.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">444</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1032</span> Construction and Performance of Nanocomposite-Based Electrochemical Biosensor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianfang%20Wang">Jianfang Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Xianzhe%20Chen"> Xianzhe Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhuoliang%20Liu"> Zhuoliang Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Cheng-An%20Tao"> Cheng-An Tao</a>, <a href="https://publications.waset.org/abstracts/search?q=Yujiao%20Li"> Yujiao Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Organophosphorus (OPs) pesticide used as insecticides are widely used in agricultural pest control, household and storage deworming. The detection of pesticides needs more simple and efficient methods. One of the best ways is to make electrochemical biosensors. In this paper, an electrochemical enzyme biosensor based on acetylcholine esterase (AChE) was constructed, and its sensing properties and sensing mechanisms were studied. Reduced graphene oxide-polydopamine complexes (RGO-PDA), gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) were prepared firstly and composited with AChE and chitosan (CS), then fixed on the glassy carbon electrode (GCE) surface to construct the biosensor GCE/RGO-PDA-AuNPs-AgNPs-AChE-CS by one-pot method. The results show that graphene oxide (GO) can be reduced by dopamine (DA) and dispersed well in RGO-PDA complexes. And the composites have a synergistic catalysis effect and can improve the surface resistance of GCE. The biosensor selectively can detect acetylcholine (ACh) and OPs pesticide with good linear range and high sensitivity. The performance of the biosensor is affected by the ratio and adding ways of AChE and the adding of AuNPs and AChE. And the biosensor can achieve a detection limit of 2.4 ng/L for methyl parathion and a wide linear detection range of 0.02 ng/L ~ 80 ng/L, and has excellent stability, good anti-interference ability, and excellent preservation performance, indicating that the sensor has practical value. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acetylcholine%20esterase" title="acetylcholine esterase">acetylcholine esterase</a>, <a href="https://publications.waset.org/abstracts/search?q=electrochemical%20biosensor" title=" electrochemical biosensor"> electrochemical biosensor</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=organophosphates" title=" organophosphates"> organophosphates</a>, <a href="https://publications.waset.org/abstracts/search?q=reduced%20graphene%20oxide" title=" reduced graphene oxide"> reduced graphene oxide</a> </p> <a href="https://publications.waset.org/abstracts/116820/construction-and-performance-of-nanocomposite-based-electrochemical-biosensor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/116820.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">112</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1031</span> Isolation, Characterization and Biological Activities of Compounds Isolated from Callicarpa maingayi</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20A.%20Ado">Muhammad A. Ado</a>, <a href="https://publications.waset.org/abstracts/search?q=Intan%20S.%20Ismail"> Intan S. Ismail</a>, <a href="https://publications.waset.org/abstracts/search?q=Hasanah%20M.%20Ghazali"> Hasanah M. Ghazali</a>, <a href="https://publications.waset.org/abstracts/search?q=Faridah%20Abas"> Faridah Abas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, we have investigated the phytochemical constituents of soluble fractions of dichloromethane (DCM) of methanolic leaves extract of the Callicarpa maingayi. The phytochemicals investigation has resulted in the isolation of three triterpenoids (euscaphic acid (1), arjunic acid (2), and ursolic acid (3)) together with two flavones apigenin (4) and acacetin (5)), two phytosterols (stigmasterol 3-O-β-glycopyranoside (6) and sitosterol 3-O-β-glycopyranoside (7)), and one fatty acid (n-hexacosanoic acid (8)). Six (6) compounds isolated from this species were isolated for the first time (1, 2, 3, 4, 5, and 8). Their structures were elucidated and identified by spectral methods of one and two-dimensional NMR techniques, gas chromatography-mass spectrometry, and comparison with the previously reported literature. The biological activity of three compounds (1-3) was carried out on acetylcholinesterase inhibition activity. Compound (3) was found to displayed good inhibition against AChE with an IC₅₀ value of 21.5 ± 0.022 μM. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acetylcholinesterase" title="acetylcholinesterase">acetylcholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=Callicarpa%20maingayi" title=" Callicarpa maingayi"> Callicarpa maingayi</a>, <a href="https://publications.waset.org/abstracts/search?q=euscaphic%20acid" title=" euscaphic acid"> euscaphic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=ursolic%20acid" title=" ursolic acid"> ursolic acid</a> </p> <a href="https://publications.waset.org/abstracts/132971/isolation-characterization-and-biological-activities-of-compounds-isolated-from-callicarpa-maingayi" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/132971.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">146</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1030</span> Pathological Gambling and Impulsivity: Comparison of the Eight Laboratory Measures of Inhibition Capacities</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Semion%20Kertzman">Semion Kertzman</a>, <a href="https://publications.waset.org/abstracts/search?q=Pinhas%20Dannon"> Pinhas Dannon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Impulsive behaviour and the underlying brain processes are hypothesized to be central in the development and maintenance of pathological gambling. Inhibition ability can be differentially impaired in pathological gamblers (PGs). Aims: This study aimed to compare the ability of eight widely used inhibition measures to discriminate between PGs and healthy controls (HCs). Methods: PGs (N=51) and demographically matched HCs (N=51) performed cognitive inhibition (the Stroop), motor inhibition (the Go/NoGo) and reflective inhibition (the Matching Familiar Figures (MFFT)) tasks. Results: An augmented total interference response time in the Stroop task (η² =0.054), a large number of commission errors (η² =0.053) in the Go/NoGo task, and the total number of errors in the MFFT (η² =0.05) can discriminate PGs from HCs. Other measures are unable to differentiate between PGs and HCs. No significant correlations were observed between inhibition measures. Conclusion: Inhibition measures varied in the ability to discriminate PGs from HCs. Most inhibition measures were not relevant to gambling behaviour. PGs do not express rash, impulsive behaviour, such as quickly choosing an answer without thinking. In contrast, in PGs, inhibition impairment was related to slow-inaccurate performance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pathological%20gambling" title="pathological gambling">pathological gambling</a>, <a href="https://publications.waset.org/abstracts/search?q=impulsivity" title=" impulsivity"> impulsivity</a>, <a href="https://publications.waset.org/abstracts/search?q=neurocognition" title=" neurocognition"> neurocognition</a>, <a href="https://publications.waset.org/abstracts/search?q=addiction" title=" addiction"> addiction</a> </p> <a href="https://publications.waset.org/abstracts/54541/pathological-gambling-and-impulsivity-comparison-of-the-eight-laboratory-measures-of-inhibition-capacities" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54541.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">302</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1029</span> Evaluation of Acetylcholinesterase, Glutathione S-Transferase and Catalase Activities in the Land Snail Helix aspersa Exposed to Thiamethoxam</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ait%20Hamlet%20Smina">Ait Hamlet Smina</a>, <a href="https://publications.waset.org/abstracts/search?q=Bensoltane%20Samira"> Bensoltane Samira</a>, <a href="https://publications.waset.org/abstracts/search?q=Djekoun%20Mohamed"> Djekoun Mohamed</a>, <a href="https://publications.waset.org/abstracts/search?q=Berrebbah%20Houria"> Berrebbah Houria</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In Algeria, the use of insecticides and other phytosanitary products are considerably spreading with the development of agriculture. But, the analyses of the residues of pesticides are not systematically made. In this context, we estimated through an experimental study, the effect of a neonicotinoid insecticide, the thiamethoxam which is used as a commercial preparation on the land snail Helix aspersa. This snail is one of the most abundant gastropod in North-East Algeria. Little information is available in the literature concerning the study of the biochemical markers of mollusks which are exposed to insecticides and especially, thiamethoxam.In this work, adult snails Helix aspersa were used to estimate the effect of a neonicotinoid insecticide (thiamethoxam) on the acetylcholinesterase (AChE), glutathione S-transferase (GST) and catalase (CAT) activities in this gastropod after a treatment of 6 weeks. During this period, snails were exposed by ingestion and contact to fresh lettuce leaves which were soaked with an insecticide solution. The thiamethoxam test solutions were 0, 25, 50, 100 and 200 mg/L, which are lower or equal to the concentrations that are applied in field. The results showed that the enzymatic activities of AChE and GST and CAT increased significantly with a dose-dependent manner. These results confirmed the toxic effect of thiamethoxam on snails exposed to the lettuce contaminated with this neonicotinoid insecticide, likely to be used as biomarker of exposure, at first to thiamethoxam then to other insecticides belonging to the same chemical family, currently present in the environment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=helix%20aspersa" title="helix aspersa">helix aspersa</a>, <a href="https://publications.waset.org/abstracts/search?q=insecticide" title=" insecticide"> insecticide</a>, <a href="https://publications.waset.org/abstracts/search?q=thiamethoxam" title=" thiamethoxam"> thiamethoxam</a>, <a href="https://publications.waset.org/abstracts/search?q=AChE" title=" AChE"> AChE</a>, <a href="https://publications.waset.org/abstracts/search?q=GST" title=" GST"> GST</a>, <a href="https://publications.waset.org/abstracts/search?q=CAT" title=" CAT "> CAT </a> </p> <a href="https://publications.waset.org/abstracts/13086/evaluation-of-acetylcholinesterase-glutathione-s-transferase-and-catalase-activities-in-the-land-snail-helix-aspersa-exposed-to-thiamethoxam" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13086.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">452</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1028</span> Bioactivity of Local Isolated Probiotic to Inhibiting Important Bacterial Pathogens in Aquaculture </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abhichet%20Nobhiwong">Abhichet Nobhiwong</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiraporn%20Rojtinnakorn"> Jiraporn Rojtinnakorn</a>, <a href="https://publications.waset.org/abstracts/search?q=Udomluk%20Sompong"> Udomluk Sompong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Six probiotic strains isolated from Chiang Mai and Chiang Rai province, Thailand; CR1-2, CM3-4, CM5-2, CR7-8, CM10-5 and CM10-8 were used to study their morphology and inhibition activity on three pathogenic bacteria; Aeromonas sp., Streptococcus sp. and Flavobacterium sp. that isolated from infected Nile tilapia. The agar well diffusion technique was applied for 24 and 48 hours incubation. Interestingly, some probiotics showed good inhibition activity both 24 and 48 hours on each 3 bacterial pathogens. The capable inhibiting Aeromonas sp. were CR1-2 and CR5-2 with inhibition diameters of 13.0 mm and 11.2 mm, respectively. For Streptococcus sp., effective probiotics were CR10-2 with inhibition diameters of 10.7 mm. Whereas for Flavobacterium sp., effective probiotics were CR5-2 with inhibition diameter of 9.7 mm. It can be concluded that these probiotics have potentiality to develop as the pathogens biocontrol products. These will be support for safety and organic aquaculture that which the most worthy for people health. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=probiotics" title="probiotics">probiotics</a>, <a href="https://publications.waset.org/abstracts/search?q=Aeromanas%20sp." title=" Aeromanas sp."> Aeromanas sp.</a>, <a href="https://publications.waset.org/abstracts/search?q=Streptococcus%20sp." title=" Streptococcus sp."> Streptococcus sp.</a>, <a href="https://publications.waset.org/abstracts/search?q=Flavobacterium%20sp." title=" Flavobacterium sp."> Flavobacterium sp.</a> </p> <a href="https://publications.waset.org/abstracts/64898/bioactivity-of-local-isolated-probiotic-to-inhibiting-important-bacterial-pathogens-in-aquaculture" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64898.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1027</span> Immunosupressive Effect of Chloroquine through the Inhibition of Myeloperoxidase</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=J.%20B.%20Minari">J. B. Minari</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20B.%20Oloyede"> O. B. Oloyede</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polymorphonuclear neutrophils (PMNs) play a crucial role in a variety of infections caused by bacteria, fungi, and parasites. Indeed, the involvement of PMNs in host defence against Plasmodium falciparum is well documented both in vitro and in vivo. Many of the antimalarial drugs such as chloroquine used in the treatment of human malaria significantly reduce the immune response of the host in vitro and in vivo. Myeloperoxidase is the most abundant enzyme found in the polymorphonuclear neutrophil which plays a crucial role in its function. This study was carried out to investigate the effect of chloroquine on the enzyme. In investigating the effects of the drug on myeloperoxidase, the influence of concentration, pH, partition ratio estimation and kinetics of inhibition were studied. This study showed that chloroquine is concentration-dependent inhibitor of myeloperoxidase with an IC50 of 0.03 mM. Partition ratio estimation showed that 40 enzymatic turnover cycles are required for complete inhibition of myeloperoxidase in the presence of chloroquine. The influence of pH on the effect of chloroquine on the enzyme showed significant inhibition of myeloperoxidase at physiological pH. The kinetic inhibition studies showed that chloroquine caused a non-competitive inhibition with an inhibition constant Ki of 0.27mM. The results obtained from this study shows that chloroquine is a potent inhibitor of myeloperoxidase and it is capable of inactivating the enzyme. It is therefore considered that the inhibition of myeloperoxidase in the presence of chloroquine as revealed in this study may partly explain the impairment of polymorphonuclear neutrophil and consequent immunosuppression of the host defence system against secondary infections. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=myeloperoxidase" title="myeloperoxidase">myeloperoxidase</a>, <a href="https://publications.waset.org/abstracts/search?q=chloroquine" title=" chloroquine"> chloroquine</a>, <a href="https://publications.waset.org/abstracts/search?q=inhibition" title=" inhibition"> inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrophil" title=" neutrophil"> neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=immune" title=" immune"> immune</a> </p> <a href="https://publications.waset.org/abstracts/7033/immunosupressive-effect-of-chloroquine-through-the-inhibition-of-myeloperoxidase" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7033.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">374</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1026</span> Neurotoxic Effects Assessment of Metformin in Danio rerio</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gustavo%20Axel%20Elizalde-Vel%C3%A1zquez">Gustavo Axel Elizalde-Velázquez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Metformin is the first line of oral therapy to treat type II diabetes and is also employed as a treatment for other indications, such as polycystic ovary syndrome, cancer, and COVID-19. Recent data suggest it is the aspirin of the 21st century due to its antioxidant and anti-aging effects. However, increasingly current articles indicate its long-term consumption generates mitochondrial impairment. Up to date, it is known metformin increases the biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription, but further information related to brain damage after its consumption is missing. Bearing in mind the above, this work aimed to establish whether or not chronic exposure to metformin may alter swimming behavior and induce neurotoxicity in Danio rerio adults. For this purpose, 250 Danio rerio grown-ups were assigned to six tanks of 50 L of capacity. Four of the six systems contained 50 fish, while the remaining two had 25 fish (≈1 male:1 female ratio). Every system with 50 fish was allocated one of the three metformin treatment concentrations (1, 20, and 40 μg/L), with one system as the control treatment. Systems with 25 fish, on the other hand, were used as positive controls for acetylcholinesterase (10 μg/L of Atrazine) and oxidative stress (3 μg/L of Atrazine). After four months of exposure, a mean of 32 fish (S.D. ± 2) per group of MET treatment survived, which were used for the evaluation of behavior with the Novel Tank test. Moreover, after the behavioral assessment, we aimed to collect the blood and brains of all fish from all treatment groups. For blood collection, fish were anesthetized with an MS-222 solution (150 mg/L), while for brain gathering, fish were euthanized using the hypothermic shock method (2–4 °C). Blood was employed to determine CASP3 activity and the percentage of apoptotic cells with the TUNEL assay, and brains were used to evaluate acetylcholinesterase activity, oxidative damage, and gene expression. After chronic exposure, MET-exposed fish exhibited less swimming activity when compared to control fish. Moreover, compared with the control group, MET significantly inhibited the activity of AChE and induced oxidative damage in the brain of fish. Concerning gene expression, MET significantly upregulated the expression of Nrf1, Nrf2, BAX, p53, BACE1, APP, PSEN1, and downregulated CASP3 and CASP9. Although MET did not overexpress the CASP3 gene, we saw a meaningful rise in the activity of this enzyme in the blood of fish exposed to MET compared to the control group, which we then confirmed by a high number of apoptotic cells in the TUNEL assay. To the best of our understanding, this is the first study that delivers evidence of oxidative impairment, apoptosis, AChE alteration, and overexpression of B- amyloid-related genes in the brain of fish exposed to metformin. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=AChE%20inhibition" title="AChE inhibition">AChE inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=CASP3%20activity" title=" CASP3 activity"> CASP3 activity</a>, <a href="https://publications.waset.org/abstracts/search?q=NovelTank%20test" title=" NovelTank test"> NovelTank test</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20damage" title=" oxidative damage"> oxidative damage</a>, <a href="https://publications.waset.org/abstracts/search?q=TUNEL%20assay" title=" TUNEL assay"> TUNEL assay</a> </p> <a href="https://publications.waset.org/abstracts/163016/neurotoxic-effects-assessment-of-metformin-in-danio-rerio" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163016.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">86</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1025</span> The Equality Test of Ceftriaxone Anti-Bacterial Effect and Ethanol Extract of Ant Plant (Myermecodia pendens Merr. and L. M Perry) to MRSA </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rifa%E2%80%99ah%20Mahmudah%20Bulu%E2%80%99">Rifa’ah Mahmudah Bulu’ </a> </p> <p class="card-text"><strong>Abstract:</strong></p> MRSA is an important nosocomial pathogen in the world. Therefore, the prevention and effort to control MRSA is still very important to conduct. One of the preventions of MRSA, which have been reported by several studies, is Cefriaxone and Ethanol Extract of Ant Plant. This research is an experimental test to determine the potency of MRSA’s anti-bacterial with Cefriaxone (30 μg) and Ethanol Extract of Ant Plant (13 mg/ml) based on inhibition zone on LAB (Lempeng Agar Biasa). The size of inhibition zone that is formed on Cefriaxone is adjusted with CSLI criteria, which ≥ 21 mm of inhibition zone is called sensitive; ≤13 mm is called resistance and between 14-20 mm is called intermediate. This research is conducted three times. Comparative test between Cefriaxone and Ethanol Extract of Ant Plant is analyzed by Maan Whitney’s statistic method. The Result of Cefriaxone anti-bacterial potency shows the variety of inhibition zone. Cefriaxone forms approximately 16,5-20 mm with average 18,22mm of inhibition zone that make Cefriaxone’s criteria to MRSA’s inhibition is intermediate. Anti-bacterial potency of Ethanol Extract of Ant Plant is about 0,5-2 mm with average 1,17 mm of inhibition zone that prove MRSA is sensitive to Ant Plant. The conclusion of this research shows that Cefriaxone is intermediate to MRSA’s inhibition, while MRSA is sensitive to Ethanol Extract of Ant Plant, which at the end; it creates different potency of anti-bacterial between Cefriaxone and Ethanol Extract of Ant Plant. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MRSA" title="MRSA">MRSA</a>, <a href="https://publications.waset.org/abstracts/search?q=cefriaxone" title=" cefriaxone"> cefriaxone</a>, <a href="https://publications.waset.org/abstracts/search?q=ant%20plant" title=" ant plant"> ant plant</a>, <a href="https://publications.waset.org/abstracts/search?q=CSLI" title=" CSLI"> CSLI</a>, <a href="https://publications.waset.org/abstracts/search?q=mann%20whitney" title=" mann whitney"> mann whitney</a> </p> <a href="https://publications.waset.org/abstracts/39334/the-equality-test-of-ceftriaxone-anti-bacterial-effect-and-ethanol-extract-of-ant-plant-myermecodia-pendens-merr-and-l-m-perry-to-mrsa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39334.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">367</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1024</span> Evaluation of the Analgesic Activity of Defatted Methanol Extract of Capparis spinosa L. Root Barks</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Asma%20Meddour">Asma Meddour</a>, <a href="https://publications.waset.org/abstracts/search?q=Mouloud%20Yahia"> Mouloud Yahia</a>, <a href="https://publications.waset.org/abstracts/search?q=Afaf%20Benhouda"> Afaf Benhouda</a>, <a href="https://publications.waset.org/abstracts/search?q=Souhila%20Benbia"> Souhila Benbia</a>, <a href="https://publications.waset.org/abstracts/search?q=Hachani%20Khadhraoui"> Hachani Khadhraoui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Peripheral analgesic activity of defatted methanol extract of root barks of Capparis spinosa was tested orally at the dose of 100 and 200 mg/kg against pain induced by acetic acid in rats. The dose of 200 mg/kg presents significant analgesic effect with a percentage of inhibition of torsions of 88.51% compared to the positive control which is the acetylsalicylic acid which represents a percentage of inhibition of 92.55%. The dose of 100 mg/kg presents a percentage of inhibition of 81.68%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=peripheral%20analgesic%20activity" title="peripheral analgesic activity">peripheral analgesic activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Capparis%20spinosa" title=" Capparis spinosa"> Capparis spinosa</a>, <a href="https://publications.waset.org/abstracts/search?q=percentage%20of%20inhibition%20of%20torsions" title=" percentage of inhibition of torsions"> percentage of inhibition of torsions</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20sciences" title=" chemical sciences"> chemical sciences</a> </p> <a href="https://publications.waset.org/abstracts/6423/evaluation-of-the-analgesic-activity-of-defatted-methanol-extract-of-capparis-spinosa-l-root-barks" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6423.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1023</span> Downhole Corrosion Inhibition Treatment for Water Supply Wells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nayif%20Alrasheedi">Nayif Alrasheedi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sultan%20Almutairi"> Sultan Almutairi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Field-wide, a water supply wells’ downhole corrosion inhibition program is being applied to maintain downhole component integrity and keep the fluid corrosivity below 5 MPY. Batch treatment is currently used to inject the oil field chemical. This work is a case study consisting of analytical procedures used to optimize the frequency of the good corrosion inhibition treatments. During the study, a corrosion cell was fitted with a special three-electrode configuration for electrochemical measurements, electrochemical linear polarization, corrosion monitoring, and microbial analysis. This study revealed that the current practice is not able to mitigate material corrosion in the downhole system for more than three months. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=downhole%20corrosion%20inhibition" title="downhole corrosion inhibition">downhole corrosion inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=electrochemical%20measurements" title=" electrochemical measurements"> electrochemical measurements</a>, <a href="https://publications.waset.org/abstracts/search?q=electrochemical%20linear%20polarization" title=" electrochemical linear polarization"> electrochemical linear polarization</a>, <a href="https://publications.waset.org/abstracts/search?q=corrosion%20monitoring" title=" corrosion monitoring"> corrosion monitoring</a> </p> <a href="https://publications.waset.org/abstracts/150495/downhole-corrosion-inhibition-treatment-for-water-supply-wells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150495.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">182</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1022</span> Aqueous Extract of Argemone Mexicana Roots for Effective Corrosion Inhibition of Mild Steel in HCl Environment </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gopal%20Ji">Gopal Ji</a>, <a href="https://publications.waset.org/abstracts/search?q=Priyanka%20Dwivedi"> Priyanka Dwivedi</a>, <a href="https://publications.waset.org/abstracts/search?q=Shanthi%20Sundaram"> Shanthi Sundaram</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajiv%20Prakash"> Rajiv Prakash</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Inhibition effect of aqueous Argemone Mexicana root extract (AMRE) on mild steel corrosion in 1 M HCl has been studied by weight loss, Tafel polarization curves, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques. Results indicate that inhibition ability of AMRE increases with the increasing amount of the extract. A maximum corrosion inhibition of 94% is acknowledged at the extract concentration of 400 mg L-1. Polarization curves and impedance spectra reveal that both cathodic and anodic reactions are suppressed due to passive layer formation at metal-acid interface. It is also confirmed by SEM micro graphs and FTIR studies. Furthermore, the effects of acid concentration (1-5 M), immersion time (120 hours) and temperature (30-60˚C) on inhibition potential of AMRE have been investigated by weight loss method and electrochemical techniques. Adsorption mechanism is also proposed on the basis of weight loss results, which shows good agreement with Langmuir isotherm. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mild%20steel" title="mild steel">mild steel</a>, <a href="https://publications.waset.org/abstracts/search?q=polarization" title=" polarization"> polarization</a>, <a href="https://publications.waset.org/abstracts/search?q=SEM" title=" SEM"> SEM</a>, <a href="https://publications.waset.org/abstracts/search?q=acid%20corrosion" title=" acid corrosion"> acid corrosion</a>, <a href="https://publications.waset.org/abstracts/search?q=EIS" title=" EIS"> EIS</a>, <a href="https://publications.waset.org/abstracts/search?q=green%20inhibition" title=" green inhibition"> green inhibition</a> </p> <a href="https://publications.waset.org/abstracts/15600/aqueous-extract-of-argemone-mexicana-roots-for-effective-corrosion-inhibition-of-mild-steel-in-hcl-environment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15600.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">491</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=5">5</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=6">6</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=7">7</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=8">8</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=9">9</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=10">10</a></li> <li class="page-item disabled"><span class="page-link">...</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=35">35</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=36">36</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=AChE%20and%20BChE%20inhibition&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>