Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A

<!DOCTYPE html> <html lang="pt"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <title>Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A | 127879</title> <meta name="keywords" content="Megan Smith, Chris Mehdizadeh, Avrodet Mourkus, Saad Ansari A, "/> <meta name="description" content="Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against both gram positive and negative bacteria, including Pseudomonas aerugino..127879"/> <meta name="citation_publisher" content="么mica Internacional" /> <meta name="citation_journal_title" content="Toxicologia: Acesso Aberto"> <meta name="citation_title" content="Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A Case Report"> <meta name="citation_author" content="Megan Smith" /> <meta name="citation_author" content="Chris Mehdizadeh" /> <meta name="citation_author" content="Avrodet Mourkus" /> <meta name="citation_author" content="Saad Ansari A" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="9"> <meta name="citation_issue" content="6"> <meta name="citation_abstract" content="Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against both gram positive and negative bacteria, including Pseudomonas aeruginosa [1]. Cefepime is most commonly used for urinary tract infections, soft tissue infections, and febrile neutropenia [2]. Up to 15% of ICU patients on cefepime may experience cefepime-induced neurotoxicity, with risk factors including renal dysfunction, excessive dosage, elevated serum cefepime concentrations, and history of prior brain injury [3]. The adverse effects of cefepime-induced neurotoxicity including encephalopathy, seizures, and coma can be resolved with drug cessation, antiepileptics, or hemodialysis [3]. Here, we present the case of cefepime induced neurotoxicity in a 59-year-old female patient with long-term cefepime antibiotic prescription for Pseudomonal endocarditis and bacteremia with multiple risk factors for reduced renal function. We discuss the relevant risk factors and preventive measures that may have prevented her from developing encephalopathy, as well as the importance of early recognition and prevention of cefepime-induced neurotoxicity in patient care."> <meta name="citation_abstract_html_url" content="https://portuguese.omicsonline.org/abstract/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html"> <link rel="shortcut icon" href="https://portuguese.omicsonline.org/assets/images/favicon.ico"/> <meta http-equiv="Content-Language" content="pt"> <link rel="canonical" href="https://portuguese.omicsonline.org/peer-reviewed/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html"> <meta name="google-site-verification" content="qN-HrL2WXoaG2H19_JlH51p2Wb35uW3rvhvy4fVnXnE" /> <link rel="alternate" href="https://portuguese.omicsonline.org/peer-reviewed/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html" hreflang="pt-BR"/> 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Cefepime is most commonly used for urinary tract infections, soft tissue infections, and febrile neutropenia [2]. Up to 15% of ICU patients on cefepime may experience cefepime-induced neurotoxicity, with risk factors including renal dysfunction, excessive dosage, elevated serum cefepime concentrations, and history of prior brain injury [3].</p> <p>The adverse effects of cefepime-induced neurotoxicity including encephalopathy, seizures, and coma can be resolved with drug cessation, antiepileptics, or hemodialysis [3]. Here, we present the case of cefepime induced neurotoxicity in a 59-year-old female patient with long-term cefepime antibiotic prescription for Pseudomonal endocarditis and bacteremia with multiple risk factors for reduced renal function. We discuss the relevant risk factors and preventive measures that may have prevented her from developing encephalopathy, as well as the importance of early recognition and prevention of cefepime-induced neurotoxicity in patient care.</p></p> <div class="alert alert-info text-left"><b>Isen莽茫o de responsabilidade:</b> Este resumo foi traduzido usando ferramentas de intelig锚ncia artificial e ainda n茫o foi revisado ou verificado.</div> <div class="nav social-icons align-items-center"> <p class="m-0">Compartilhe esta p谩gina:</p> <a class="nav-link" title="Clique aqui" target="_blank" rel="noopener" href="https://www.facebook.com/sharer.php?u=https://portuguese.omicsonline.org/abstract/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Clique aqui" target="_blank" rel="noopener" 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Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A | 127879