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In Rodents</a></li> <li><a href="https://www.compbio.com/subcutaneous-implants-video/">Subcutaneous Implants + Video</a></li> </ul> </li> </ul> </div> </div> </div> <div id="primary" class="content-area medium-9 columns"> <div class="header-title"> <h1 class="entry-title">Model Of Nasal Aspergillosis In Rabbits</h1> </div> <main id="main" class="site-main" role="main"> <article id="post-4120" class="post-4120 page type-page status-publish hentry"> <div id="breadcrumb"> <div id="crumbs"><span class="crumb"><a href="https://www.compbio.com">Home</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href="https://www.compbio.com/pulmonary/">Pulmonary</a></span> <i class="fa fa-angle-right"></i> <span class="current">Model Of Nasal Aspergillosis In Rabbits</span></div> </div> <div class="entry-content"> <div class="the-content-contain"> <div class="row builder-row content-row"> <div class="medium-12 columns"> <p><img class="alignleft size-medium wp-image-3908" src="https://www.compbio.com/images/152_4_x100b.mr__-300x226.jpg?v=1713387119" alt="" width="300" height="226"><img loading="lazy" class="alignleft size-medium wp-image-3907" src="https://www.compbio.com/images/151-2_x100a.mr__-300x226.jpg?v=1713387104" alt="" width="300" height="226" srcset="https://www.compbio.com/images/151-2_x100a.mr__-300x226.jpg?v=1713387104 300w, https://www.compbio.com/images/151-2_x100a.mr__-768x578.jpg?v=1713387098 768w, https://www.compbio.com/images/151-2_x100a.mr__-1024x771.jpg?v=1713387092 1024w, https://www.compbio.com/images/151-2_x100a.mr__.jpg?v=1713387086 1360w" sizes="(max-width: 300px) 100vw, 300px"></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p class="p1"><em><span class="s1">Left: Low magnification photomicrograph demonstrating conidia in a fungal granuloma in the sinus of a rabbit (PAS)                                        </span></em></p> <p class="p1"><em><span class="s1">Right: High magnification of photomicrograph demonstrating conidia in a fungal granuloma in the sinus of a rabbit (PAS)</span></em></p> <p> </p> <p><strong>Model of Nasal Aspergillosis in Rabbits</strong></p> <p>Systemic aspergillosis is common opportunistic infection in immunocompromized and to a lesser extent in immunocompetent, patients.  Aspergillus is a ubiquitous saprophyte and infection is both a Third World disease and a disease of immunosuppression such as AIDS, cancer, and diabetes.  Benign and malignant forms including allergic, chronic-necrotizing, aspergilloma, and invasive forms occur in humans.  Patient clinical signs, CT scanning and fungal culture are common diagnostic tools.  Treatment generally includes surgical debridement, drainage and microbial chemotherapy such as ketoconazole or itraconazole.  Aspergillosis occurs in a number of veterinary settings as well, also generally with immunosuppressed animals.</p> <p>Chronic invasive fungal rhinosinusitis (<em>Aspergillus fumigatus</em>) may occur in subtle immunosuppression as seen in diabetes, corticosteroid use and human immunodeficiency virus infection as well as in patients without obvious immune defects.  This condition may present as either an invasive or noninvasive form based upon the histopathological findings of the invaded tissue.  The non-invasive category of fungal sinusitis is defined by the absence of hyphae within the mucosal and other tissues of the paranasal sinuses and includes fungal colonization, fungal ball and allergic fungal rhinosinusitis while the invasive for of fungal rhinosinusitis is defined by the presence of fungal hyphae within the mucosa, submucosa, bone or blood vessels of the paranasal sinuses.</p> <p>CBI has developed and validated a surgically-induced model of either invasive or noninvasive nasal aspergillosis infection in rabbits. In this model, a fungal infection in the sinus is established using proprietary methodology, and then various modalities for treatment are assessed.  Studies are custom designed specifically for each sponsor and test article.</p> <p>Study parameters may include:</p> <ul> <li>Clinical signs, body weight and food consumption</li> <li>Hematology and clinical chemistry</li> <li>Bioassays for cytokines, immunologic and other markers</li> <li>CT scanning and digital radiology</li> <li>Quantitative fungal culture</li> <li>PCR, qPCR and Elisa</li> <li>Histopathology and Immunohistochemistry</li> </ul> <p><strong><a href="https://www.compbio.com/contact-us/">Contact us</a> to discuss a scientific study program to fit your Preclinical needs.</strong></p> <p> </p> <h3><a href="https://www.compbio.com/files/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus.pdf?v=1713387303">A pilot study of antimicrobial photodynamic therapy of encapsulated Aspergillus fumigatus in a rabbit maxillary sinus model – Poster</a></h3> <p>Aspergillus fumigatus is a commonly isolated agent in invasive aspergillosis and chronic invasive fungal rhinosinusitis. These conditions are often associated with immunosuppression. Standard management involves surgical debridement and long-term antifungal treatment (3 – 15+ months, follow-up <5 yr.), along with tight glycemic control and discontinuation of corticosteroids. Prompt diagnosis and initiation of appropriate therapy for relapse are essential to avoid a protracted or fatal outcome. This study was undertaken to demonstrate the potential for antimicrobial photodynamic disinfection (PDD) in the treatment of aspergillosis.</p> <p> </p> <p><a href="https://www.compbio.com/files/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus.pdf?v=1713387303">click here: SPIE- a pilot study of antimicrobial photodynamic theraphy of encapsulated A. fumigatus in arabbit maxillary sinus</a></p> <p> </p> <p><img loading="lazy" class="wp-image-4620 alignnone" src="https://www.compbio.com/images/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus-2-262x300.jpg?v=1713387280" alt="" width="895" height="1025" srcset="https://www.compbio.com/images/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus-2-262x300.jpg?v=1713387280 262w, https://www.compbio.com/images/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus-2-895x1024.jpg?v=1713387275 895w, https://www.compbio.com/images/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus-2-768x879.jpg?v=1713387266 768w, https://www.compbio.com/images/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus-2-1342x1536.jpg?v=1713387261 1342w, https://www.compbio.com/images/SPIE-a-pilot-study-of-antimicrobial-photodynamic-theraphy-of-encapsulated-A.-fumigatus-in-arabbit-maxillary-sinus-2-1790x2048.jpg?v=1713387254 1790w" sizes="(max-width: 895px) 100vw, 895px"></p> </div> </div> </div> </div> </article> </main> </div> </div> <div class="call-out"> <h3 class="content-left"><span class="line-one">Have a question</span> <span class="line-two">or need a quote?</span></h3> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 85" style="enable-background:new 0 0 100 85;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} </style> <g> <path class="st0" d="M64.3,0.5H16c-8.8,0-16,7.2-16,16V44c0,8.4,6.6,15.4,14.9,16l-3.7,17.4L31.6,60h8.8V43.9 c0-8.7,7.1-15.8,15.8-15.8h24.2V16.5C80.3,7.7,73.1,0.5,64.3,0.5z"/> <path class="st0" d="M89.1,33h-33c-6,0-10.9,4.9-10.9,10.9v18.8c0,6,4.9,10.9,10.9,10.9h22.4l13.9,11.8l-2.5-11.9 c5.7-0.4,10.2-5.1,10.2-10.9V44C100,38,95.1,33,89.1,33z M85.5,49.3c2.2,0,4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1s-4-1.8-4-4.1 C81.5,51.1,83.3,49.3,85.5,49.3z M59.6,57.4c-2.2,0-4-1.8-4-4.1c0-2.2,1.8-4.1,4-4.1c2.2,0,4,1.8,4,4.1 C63.7,55.6,61.9,57.4,59.6,57.4z M68.5,53.4c0-2.2,1.8-4.1,4-4.1s4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1S68.5,55.6,68.5,53.4z"/> </g> </svg> <h3 class="content-right"><span>We can help!</span> <a href="https://www.compbio.com/contact-us/"><span class="cta-btn">Contact us</span></a></h3> </div> </div> </div> <footer id="colophon" class="site-footer row"> <div class="site-info medium-12 columns"> Comparative Biosciences, Inc. · <strong>Phone: 888-994-4879</strong><br> Copyright 2024 Comparative Biosciences, Inc. 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